CN103947816A

CN103947816A - Selenium-rich chewing gum

Info

Publication number: CN103947816A
Application number: CN201410207324.2A
Authority: CN
Inventors: 柯志卫
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-05-16
Filing date: 2014-05-16
Publication date: 2014-07-30

Abstract

The invention relates to a selenium-rich chewing gum. The selenium-rich chewing gum is characterized in that Kappa-selenocarrageenan is added into a chewing gum matrix to supplement 50-200mu g of organic selenium for normal people through chewing every day. According to the selenium-rich chewing gum provided by the invention, the chewing gum is taken as a carrier for supplementing selenium, the concept is novel, the mode of usually taking selenium-containing tablets and capsules by people is broken through, the selenium-rich chewing gum is very convenient to take and carry, Kappa-selenocarrageenan is added into the chewing gum matrix to prepare the selenium-rich chewing gum, Kappa-selenocarrageenan is slowly dissolved in saliva of the people and absorbed during the process that people chew the chewing gum and then, the selenium supplement for people is simple, convenient and direct; furthermore, the price is low and the selenium-rich chewing gum is easily accepted by the people.

Description

Rich selenium chewing gum

Technical field

The present invention relates to a kind of chewing gum, specifically a kind of rich selenium chewing gum that supplements body trace element selenium.

Background technology

Trace elements of selenium (Se), is found by Sweden chemist for 1817; Nineteen fifty-seven, Germany scientist found that selenium has protection liver, prevents the effect of hepatonecrosis first.Within 1973, the World Health Organization confirms, selenium is the essential trace element of human and animal's vital movement, suggestion human body supplementary 50-200 μ g selenium every day, the effectively generation of prevention of various diseases.

The Se content of the pedotheque of Chinese Scientists in 1980 to China's 1094 counties and cities (accounting for national half) is measured, and result shows: China lacks selenium country.The county that reaches 0.1 mg/kg of the normal value that national health tissue announces only has 1/3, and China has 2/3 area to belong to lack selenium area.Wherein content <0.02 mg/kg account for 29%, belong to the serious selenium area that lacks.

1982-1991 years Sino-U.S. scientists are in cancer hotspot of China---Lin County, Henan Province, and the experiment of carrying out shows: supplement 50-200 microgram selenium every day, can significantly reduce cancer morbidity and the death rate.

Within 1983-1996 years, professor Clark of DKFZ of Arizona, USA university has carried out reaching the benefit selenium double blinding intervention test of 13 years to 1312 routine cancer patients, result shows: daily iron supplement 200 microgram selenium, metastasis of cancer rate has reduced by 37%, and the death rate has reduced by 50%.This research is called as " selenium anti-cancer milestone ".

Soil, water, cereal and centenarian blood, the Se content in hair of Chinese Scientists in 1984 to Hubei China centenarian compact community measured, and selenium is higher than 23 times of average levels.

Within 1985, Chinese Scientists is to Chinese the first Changshou District, the fourth-largest Changshou District, the world---Bama County of Guangxi is investigated, find that Ba Ma county cancer morbidity, the cardiovascular and cerebrovascular incidence of disease only have 1/20 of average national level, the Se content of soil reaches 0.5 micro-g/kg, exceedes micro-g/kg 5 times of the normal values 0.1 that WHO announces.

Within 1985-1997 years, Chinese Scientists is mended selenium test to High Phc Incidence Area, Qidong county, Jiangsu 130,000 residents, and result shows: onset of liver cancer rate has declined 35%, has the liver cancer family history person incidence of disease to decline 50%.

May 28 nineteen ninety, Japanese economy be it is reported: Japanese National Institutes of Health is found: selenium has the similar effect of insulin.

1997, China medical expert professor Yu Shuyu went through and high liver cancer incidence area be studies have shown that in 16 years: human body is higher containing selenium level, and hepatopathy, onset of liver cancer rate are lower, and scarce selenium is the major reason that causes liver cancer.The danger that in body, the long-term hepatitis that lacks selenium is converted into liver cancer is 202 times of other crowds.

Report on September 26th, 2000 " NAS's magazine ": researcher's current research is found, selenomethionine can activate tumor suppressor gene P53, P53 gene can, by impelling abnormal cell apoptosis or copying of cancer cell of blocking-up to play prevention function of tumor, disclose selenium anticancer mechanism first.

On June 4th, 2003 " the Chinese People's Political Consultative Conference " report report: international selenium is studied famous expert Chen Junshi and is said: " selenium is unique and virus infections has the nutrient of direct relation "." lack selenium and can cause virus mutation, and the saying of enhanced virus pathogenicity has scientific basis ".At present the U.S., Britain, Denmark, Sweden, Finland five state scientists are carrying out one and are being called as the clinical research in " the selenium change world ".Participant reaches people more than 50,000.

Chinese Soclety of Nutrition's suggestion, maintains normal physiological activity, at least needs 50 microgram selenium every day; Special population: as tumour, diabetes, hepatopathy, cardiovascular and cerebrovascular disease easily build up a family fortune family and cardiovascular disease, diabetes, hepatopathy, tumor patient, expert advice should supplement 100-200 microgram selenium every day.

More than 10 the national science men such as the U.S., Britain, China prove through animal experiment and human clinical trial for many years, and human body is mended selenium amount every day and is no more than 500 micrograms and is perfectly safe.

American scientist Sch rauzer and Whlfe give 10 volunteers in 1978, mend selenium 500-600 microgram every day, continuous 18 months, have no any poisoning symptom.

In general vegetable and fruit, Se content is all very low, also can only absorb a few microgram selenium even if you eat one kilogram of vegetables every day, and rice and flesh of fish class Se content are also very low, therefore causes China resident generally to lack selenium.And selenium can not store in vivo, need supplement every day.

In order to solve the problem of the long-term insufficiency of intake of China resident selenium, a lot of Selenium supplement agents and health products are developed and produced to some research institutions and cartel.At present, Selenium supplement agent mainly contains two classes: the one, and inorganic selenium is as selenite, sodium selenate, the 2nd, Organic Selenium, comprise various animal and plant and microniological proudcts that natural products that organic selenium preparation, district rich in selenium are produced and artificial bio-membrane transform, as selenomethionine, Se-enriched egg, selenium-enriched tea leaf, selenium-rich rice, Se-enriched yeast, selenium enriched Spirulina etc.

Superiority based on Organic Selenium tonic and natural organic selenium resource restricted, Chinese scholars has been carried out a large amount of research to utilizing the exogenous inorganic selenium of bio-transformation enrichment to produce Organic Selenium tonic.Selecting aspect bio-carrier, at present people have utilized edible mushroom to cultivate Se-enriched yeast, selenium enriched Spirulina, selenium-rich gold needle mushroom, mushroom with abundant selenium, Se-rich xianggu, selenium-enriched monkey head etc. for carrier, utilize crop for carrier cultivates selenium-rich rice, selenium-rich corn, product containing organic selenium, selenium-enriched tea leaf, selenium rich strawberry etc., utilize animal to produce Se-enriched egg, earthworm selenium-enriched protein etc. for carrier.The way that current people mend selenium is a lot, and still, some ways limit because being subject to eating habit, security, ability to shoulder economically and unicity, more difficultly receives good effect.For example, the rich selenium tea that high selenium area produces, although selenium content is higher, because selenium is mainly distributed among tea grounds, is dissolved in the Se content of drinking in tea few, eats and does not meet people's eating habit together with tea grounds; The agricultural product such as some selenium-rich rices, though there is the function of mending selenium, the use of a large amount of chemical fertilizer and agricultural chemicals in process of production, the pollution of residues of pesticides and heavy metal, security allows people worry; At present some mend selenium health products, all show as on the high sidely, and ordinary consumer is difficult to bear for a long time.Meanwhile, some health products are mainly made tablet, pulvis, capsule, are long-term processes and mend selenium, all must supplement every day, and time one length has the sensation of taking medicine unavoidably, will inevitably produce and be weary of sense.Especially some white collars, operating pressure is large, and health, in sub-health state, more needs to mend selenium, but make it be difficult to adhere to towards the rhythm of life in nine evenings five, therefore, if production one portably uses conveniently, cheap, can among amusement and recreation, supplement in passing selenium, not only be easy to accepted by the publicly, and emerge as a kind of new benefit selenium product, can give different crowd more to select.

Summary of the invention

Object of the present invention is just to provide a kind of rich selenium chewing gum; Using chewing gum as mending the carrier of selenium, novel, break people and usually taken the pattern containing selenium tablet, capsule, take and carry very conveniently, cheap, be easy to accepted by the public.

Technical scheme of the present invention is, adds k-selenocarrageenan in chewing gum base, makes normal person supplement Organic Selenium 50-200 μ g by chewing clothes every day.

Further, be in chewing gum base, to add k-selenocarrageenan, in every chewing gum, Se content reaches 11.2-28 μ g.

Described continuous gum base raw material composition is counted with mass fraction: polyvinyl acetate 25%-28%, xylitol 35%-40%, Aspartame 13%-15%, glycerine 0.8%-1%, acesulfame potassium 5.65%-7.15%, lecithin 0.5%-0.6%, flavoring essence 0.7%-0.75%, titanium dioxide 4%-4.5%, talcum powder 8%-10%; Described k-selenocarrageenan consumption is 0.1%-0.25%; The mass fraction sum of above-mentioned each raw material used is 100%; Its preparation method is: the first step, and get polyvinyl acetate and be added in kneader and be heated to 90-120 DEG C, fully dissolve kneading; Second step, gets talcum powder, titanium dioxide, Aspartame, xylitol, k-selenocarrageenan, glycerine, acesulfame potassium, lecithin, flavoring essence and adds respectively in the polyvinyl acetate that the first step melted, fully mixes; The 3rd step, cooling, extrusion modling, polishing, upper sugar-coat, packaging, to obtain final product.

Preferred scheme is that described chewing gum base composition consumption is: polyvinyl acetate 25kg, xylitol 40kg, Aspartame 13kg, glycerine 0.8kg, lecithin 0.6kg, flavoring essence 0.7kg, titanium dioxide 4kg, acesulfame potassium 5.8kg, talcum powder 10kg; The k-selenocarrageenan organic selenium content using is 0.8%, and k-selenocarrageenan addition is 0.1kg; When preparation, first get polyvinyl acetate and be added in kneader and be heated to 90-120 DEG C, fully fusing is mediated; Get again talcum powder, titanium dioxide, Aspartame, xylitol, k-selenocarrageenan, glycerine, acesulfame potassium, lecithin, flavoring essence and add respectively in the polyvinyl acetate having dissolved, fully mix; Cooling, extrusion modling, polishing, upper sugar-coat, packaging, to obtain final product.

Chewing gum of the present invention is by every 1.4g, and every is 11.2-28 μ g containing Organic Selenium; Population is chewed and take 4-18 objects that can reach Selenium Supplement every day.

The k-selenocarrageenan using in the present invention, claim again selenide of carragheen (kappa-selenocarrageenan), that the puritan filler lipopolysaccharides extracting from marine algae does parent, adopt accurate molecular docking technology, a kind of organic selenium compound that trace element and active polysaccharide are combined closely in molecular state, it integrates Organic Selenium and the many physiological functions of polysaccharide, has ten large functions:

1, anticancer king, experimental results demonstrate, selenic ester polysaccharide can optionally suppress the synthetic and DNA replication dna of cancer tumor cell proliferation protein, thereby plays cancer suppressing action.Can regulate and control the expression of propagation and division oncogene, make cancer cell behavior to the normal activity that can suppress with the closely-related protein kinase C of cell carcinogenesis that transforms, thereby effective inhibition cancer cell internal protein is synthetic, the growth of DNA replication dna cancer cell simultaneously.Prove that according to a large amount of clinical datas the blood selenium of cancer patient is starkly lower than areal normal population, therefore clinical expert thinks that the height of human body blood selenium level and cancer morbidity are obvious negative.

2, the treating liver necrosis protection factor, free radical and MDA have participated in the pathologic process of virus hepatitis, and liver ultra microstructure generation rationality is changed.Selenic ester polysaccharide can strengthen the activity that is distributed in the glutathione peroxidase in liver cell liquid and mitochondria, removes free radical and MDA, accelerates Hepatic function improvement, reaches the object of protection liver.

3, heart patron saint, selenium plays an important role to the 26S Proteasome Structure and Function of cardiac muscle fibre, blood vessel.In the process of body metabolism, can produce the very strong oxide of many activity, be referred to as free radical.Free radical is all with the atom of the electronics of not joining, ion, molecule, and the gene that these chemical property are active can attack cells have destructive chain reaction, finally causes the pathology of cell and tissue and aging.Lack after selenium, MDA increased response, causes biological metabolism wadding disorderly, causes cardiac muscle fibre necrosis, vascular injury.Selenic ester polysaccharide can be eliminated removing free radical effectively, thus cardioprotection, control cerebrovascular disease.

4, prevent and treat myopia and cataract, can alleviate the oxidative damage on retina containing the glutathione peroxidase of selenium.Selenium is rich content in iris and crystalline.Human retina is containing selenium 7ug, and the fierce look nethike embrane content of visus acris is up to 700ug.Cataractous generation is also relevant with scarce selenium.Selenic ester polysaccharide can effectively be prevented and treated young myopia and senile cataract.

5, the protective agent of antagonism noxious material, the toxicity of selenic ester polysaccharide energy antagonism and the many poisonous elements of reduction and material.Selenium and metal have very strong affinity, it in human body with metal in conjunction with can form-selenium-protein complex, virulent metallic element begins plumbous in this way.Mercury, arsenic, silver, etc. excrete, thereby, have people selenium to be described as to " natural antidote ".

6, anti-oxidant king, selenium resin acid polysaccharide is a kind of powerful antioxidant of one, can suppress the oxidation of unrighted acid on the various cell membranes of body.Verified: the oxidation resistant highest-capacity of selenium in selenic ester polysaccharide is 80 times of vitamin E.And previously known antioxidant OPC, its antioxygenic property is 50 times of vitamin E, therefore can say that selenic ester polysaccharide is " anti-oxidant king ".

7, improve body immunity, selenic ester polysaccharide can promote lymph born of the same parents to produce antibody, haematogenic immunity globulin levels is increased or remain normal, strengthens the ability of body to vaccine or other antigen generation antibody.Selenium can strengthen lymphocyte transformation and delayed allergy (DTH), and while lacking selenium, lymphocyte declines to the respond of mitosis primary stimuli, can promote cytophagous function and mend selenium.While lacking selenium, animal polymorphonuclear leukocyte (PMN) sterilizing power declines.USA New York medical college research discloses: aids patient blood selenium level and active hyperchromic significantly under, in its body, the content of selenium is well below just becoming crowd, low selenium is one of reason causing AIDS.Chinese scholar is confirmed at research trace elements of selenium and aids prevention and treatment relation, and taking Organic Selenium goods is effective ways of preventing and treating AIDS.Therefore selenic ester polysaccharide can improve cell and the humoral immune function of human body, strengthens the resistance of body to disease.

8, delay senility, with advancing age, in body, selenium and other polyphenoils (as: glutathione peroxidase) effect weaken, MDA strong reaction, lipid peroxide (LPO) cell membrane, nucleic acid, protein and enzyme and mitochondrial function are destroyed, cause irreversible damage, this effect accumulates for a long time, promotes body aging.So the elderly is often kind mends selenium at any time with selenium-enriched food and beverage, common being prevented with cranial vascular disease, cataract and retrogression pathological changes, reaches the object of promoting longevity.Age is larger, and physique is poorer, and effect is more obvious.

9, strengthen fecundity and reproductive function, research shows, selenium and luteinizing hormone-releasing hormone (LRH) (LHRH), sexual gland (testosterone) axle are relevant, and participate in synthesizing of prostaglandin (PG), also have certain effect in during spermatogenesis.The up-to-date research of the U.S. shows, it is relevant that selenium and women are fertilized, and can enter fetus by placenta, and therefore selenic ester polysaccharide has good impact to the normal development of normal fertility and fetus; Lack selenium women and can cause pregnancy rate to reduce retained afterbirth, the metritic incidence of disease raises.The male sex also needs often to supplement Organic Selenium because supply with Organic Selenium in body almost half all concentrate in the male sex's vas deferens, selenium also can excrete with seminal fluid; Lack the selenium male sex and easily cause production of sperm process to be obstructed, sperm motility reduces, and dead essence, lopsided essence and decreased number easily occur, and brings out male sterility.

10, smoker is had to health-care effect, smoking people easily suffers from lung cancer, and with non-smoking people comparison, micronucleus lymph occurrence rate obviously improves, and blood selenium level reduces.Clinical proof: patients with lung cancer is taken after selenic ester polysaccharide, just can make micro-lymph occurrence rate reduce, and alleviates or eliminates the damage that smoking causes human body.

Therefore, within 1993, pass through through the last instance of national food additives technical committee for standardization (TCST), can be used as food additives.This product is water-soluble, and k-selenocarrageenan is joined in chewing gum base and makes rich selenium chewing gum, and in chew gum process, k-selenocarrageenan is slowly dissolved among people's saliva and is absorbed, and makes that popular to mend selenium simpler, more convenient, more direct.

Detailed description of the invention

Embodiment 1: add k-selenocarrageenan in chewing gum base, make normal person supplement Organic Selenium 50-200 μ g by chewing clothes every day; Specifically can make Se content in every chewing gum reach 11.2-28 μ g.

Embodiment 2: take polyvinyl acetate 25kg, xylitol 40kg, Aspartame 13kg, glycerine 0.8kg, lecithin 0.6kg, flavoring essence 0.7kg, titanium dioxide 4kg, acesulfame potassium 5.8kg, talcum powder 10kg, k-selenocarrageenan 0.1kg, the k-selenocarrageenan organic selenium content using in the present embodiment is 0.8%; When preparation, first get polyvinyl acetate and be added in kneader and be heated to 90-120 DEG C, fully fusing is mediated; Get again talcum powder, titanium dioxide, Aspartame, xylitol, k-selenocarrageenan, glycerine, acesulfame potassium, lecithin, flavoring essence and add respectively in the polyvinyl acetate having dissolved, fully mix; Cooling, extrusion modling, polishing, upper sugar-coat, packaging, to obtain final product; By every 1.4g, approximately 71428 of the chewing gums of making altogether, Se content is 28 μ g in every, normal adult is chewed and take 4-6 and can reach conventional objects of mending selenium every day.

Embodiment 3 takes polyvinyl acetate 28kg, xylitol 35kg, Aspartame 15kg, glycerine 1kg, lecithin 0.5kg, flavoring essence 0.75kg, titanium dioxide 4.5kg, acesulfame potassium 7.15kg, talcum powder 8kg, k-selenocarrageenan 0.1kg, the k-selenocarrageenan organic selenium content using in the present embodiment is 0.8%; First get polyvinyl acetate and be added in kneader and be heated to 90-120 DEG C, fully fusing is mediated; Get again talcum powder, titanium dioxide, Aspartame, xylitol, k-selenocarrageenan, glycerine, acesulfame potassium, lecithin, flavoring essence and add respectively in the polyvinyl acetate having dissolved, fully mix; Cooling, extrusion modling, polishing, upper sugar-coat, packaging, to obtain final product; By every 1.4g, approximately 71428 of the chewing gums of making altogether, Se content is 11.2 μ g in every, normal adult is chewed and take 4-18 and can reach conventional objects of mending selenium every day.

In the present invention, in raw materials market used, can purchase, be food stage.

Above-described embodiment is only several embodiment of the present invention; in fact; those skilled in the art is on the basis with reference to the present invention program; can change the content of the matrix of chewing gum, consumption, specification and k-selenocarrageenan; but as long as with the prepared benefit selenium product of this carrier of chewing gum, still within protection scope of the present invention.

Claims

1. a rich selenium chewing gum, is characterized in that: in chewing gum base, add k-selenocarrageenan, make normal person supplement Organic Selenium 50-200 μ g by chewing clothes every day.

2. the rich selenium chewing gum of one according to claim 1, is characterized in that: in chewing gum base, add k-selenocarrageenan, in every chewing gum, Se content reaches 11.2-28 μ g.

3. the rich selenium chewing gum of one according to claim 1 and 2, it is characterized in that: described continuous gum base raw material composition is counted with mass fraction: polyvinyl acetate 25%-28%, xylitol 35%-40%, Aspartame 13%-15%, glycerine 0.8%-1%, acesulfame potassium 5.65%-7.15%, lecithin 0.5%-0.6%, flavoring essence 0.7%-0.75%, titanium dioxide 4%-4.5%, talcum powder 8%-10%; Described k-selenocarrageenan consumption is 0.1%-0.25%; The mass fraction sum of above-mentioned each raw material used is 100%; Its preparation method is: the first step, and get polyvinyl acetate and be added in kneader and be heated to 90-120 DEG C, fully dissolve kneading; Second step, gets talcum powder, titanium dioxide, Aspartame, xylitol, k-selenocarrageenan, glycerine, acesulfame potassium, lecithin, flavoring essence and adds respectively in the polyvinyl acetate that the first step melted, fully mixes; The 3rd step, cooling, extrusion modling, polishing, upper sugar-coat, packaging, to obtain final product.

4. according to the rich selenium chewing gum of the one described in claim 1 or 2 or 3, it is characterized in that: described chewing gum base composition consumption is: polyvinyl acetate 25kg, xylitol 40kg, Aspartame 13kg, glycerine 0.8kg, lecithin 0.6kg, flavoring essence 0.7kg, titanium dioxide 4kg, acesulfame potassium 5.8kg, talcum powder 10kg; The k-selenocarrageenan organic selenium content using is 0.8%, and k-selenocarrageenan addition is 0.1kg; When preparation, first get polyvinyl acetate and be added in kneader and be heated to 90-120 DEG C, fully fusing is mediated; Get again talcum powder, titanium dioxide, Aspartame, xylitol, k-selenocarrageenan, glycerine, acesulfame potassium, lecithin, flavoring essence and add respectively in the polyvinyl acetate having dissolved, fully mix; Cooling, extrusion modling, polishing, upper sugar-coat, packaging, to obtain final product.