CN103947650A - Bactericidal composition containing trifloxystrobin and difenoconazole and application of bactericidal composition - Google Patents
Bactericidal composition containing trifloxystrobin and difenoconazole and application of bactericidal composition Download PDFInfo
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- CN103947650A CN103947650A CN201410152290.1A CN201410152290A CN103947650A CN 103947650 A CN103947650 A CN 103947650A CN 201410152290 A CN201410152290 A CN 201410152290A CN 103947650 A CN103947650 A CN 103947650A
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- Prior art keywords
- difenoconazole
- bactericidal composition
- bacterium ester
- oxime bacterium
- water dispersible
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- 239000005760 Difenoconazole Substances 0.000 title claims abstract description 66
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 title claims abstract description 66
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 27
- 239000005857 Trifloxystrobin Substances 0.000 title abstract description 8
- ONCZDRURRATYFI-TVJDWZFNSA-N trifloxystrobin Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1CO\N=C(/C)C1=CC=CC(C(F)(F)F)=C1 ONCZDRURRATYFI-TVJDWZFNSA-N 0.000 title abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 42
- 201000010099 disease Diseases 0.000 claims abstract description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 18
- 241000221785 Erysiphales Species 0.000 claims abstract description 13
- 206010039509 Scab Diseases 0.000 claims abstract description 5
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 5
- 235000013311 vegetables Nutrition 0.000 claims abstract description 5
- 241000894006 Bacteria Species 0.000 claims description 60
- 150000002148 esters Chemical class 0.000 claims description 60
- 150000002923 oximes Chemical class 0.000 claims description 59
- 239000004562 water dispersible granule Substances 0.000 claims description 32
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 19
- 229910052708 sodium Inorganic materials 0.000 claims description 19
- 239000011734 sodium Substances 0.000 claims description 19
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 13
- 229920005551 calcium lignosulfonate Polymers 0.000 claims description 13
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 claims description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 12
- 239000004202 carbamide Substances 0.000 claims description 12
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 12
- 229920005646 polycarboxylate Polymers 0.000 claims description 12
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 11
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 11
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 11
- 239000000470 constituent Substances 0.000 claims description 11
- 239000007884 disintegrant Substances 0.000 claims description 11
- 239000002270 dispersing agent Substances 0.000 claims description 11
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- 235000013339 cereals Nutrition 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 6
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- 239000002131 composite material Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 229920005682 EO-PO block copolymer Polymers 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- -1 alkyl naphthalene sulfonic acid formaldehyde Chemical compound 0.000 description 6
- 239000003899 bactericide agent Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000000575 pesticide Substances 0.000 description 6
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 5
- 241000234295 Musa Species 0.000 description 5
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 5
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 5
- 241000209140 Triticum Species 0.000 description 5
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- 208000003351 Melanosis Diseases 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
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- 229910021653 sulphate ion Inorganic materials 0.000 description 4
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- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 3
- 238000000205 computational method Methods 0.000 description 3
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- JSYPRLVDJYQMAI-ODZAUARKSA-N (z)-but-2-enedioic acid;prop-2-enoic acid Chemical compound OC(=O)C=C.OC(=O)\C=C/C(O)=O JSYPRLVDJYQMAI-ODZAUARKSA-N 0.000 description 2
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 2
- 241000235349 Ascomycota Species 0.000 description 2
- 241000221198 Basidiomycota Species 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000233679 Peronosporaceae Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 description 2
- 235000011151 potassium sulphates Nutrition 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229960000776 sodium tetradecyl sulfate Drugs 0.000 description 2
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 2
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- PGPNJCAMHOJTEF-UHFFFAOYSA-N 1-chloro-4-phenoxybenzene Chemical compound C1=CC(Cl)=CC=C1OC1=CC=CC=C1 PGPNJCAMHOJTEF-UHFFFAOYSA-N 0.000 description 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000222195 Ascochyta Species 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 241000222199 Colletotrichum Species 0.000 description 1
- 241001480059 Erysiphaceae Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000220225 Malus Species 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241001503951 Phoma Species 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000221535 Pucciniales Species 0.000 description 1
- 241000918585 Pythium aphanidermatum Species 0.000 description 1
- 241000173767 Ramularia Species 0.000 description 1
- 241001533598 Septoria Species 0.000 description 1
- 229930182692 Strobilurin Natural products 0.000 description 1
- 241000317942 Venturia <ichneumonid wasp> Species 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- 229940054066 benzamide antipsychotics Drugs 0.000 description 1
- 150000003936 benzamides Chemical class 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
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- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
- 235000019838 diammonium phosphate Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
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- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 229940095686 granule product Drugs 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
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- 230000005764 inhibitory process Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
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- WYMSBXTXOHUIGT-UHFFFAOYSA-N paraoxon Chemical compound CCOP(=O)(OCC)OC1=CC=C([N+]([O-])=O)C=C1 WYMSBXTXOHUIGT-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing trifloxystrobin and difenoconazole and application of the bactericidal composition. In the composition, the trifloxystrobin and the difenoconazole are compounded and play a quite good synergistic effect, wherein the weight ratio of the trifloxystrobin to the difenoconazole is (1-10):(1-10). The composition disclosed by the invention has the advantages of widening the bactericidal spectrum, improving the sterilization efficiency, avoiding the drug resistance on diseases, prolonging the lasting period of medicaments, and playing a quite good effect on preventing and treating the diseases such as glume blight, powdery mildew, and scab of food crops, vegetables and fruit trees.
Description
Technical field
The present invention relates to a kind of composition pesticide, be specifically related to a kind of bactericidal composition that contains oxime bacterium ester and Difenoconazole and application thereof, belong to technical field of pesticide.
Background technology
Difenoconazole (Difenoconazole); chemical name: suitable; the chloro-4-[4-methyl-2-1H-1 of trans-3-; 2; 4-triazol-1-yl methyl)-1; mute pentane-the 2-of 3-bis-yl) phenyl 4-chlorphenyl ether; belong to triazole bactericidal agent; to Ascomycetes, Basidiomycetes with partly know disease including Alternaria, Ascochyta, the mould genus of tail spore, Colletotrichum, ball Cuo Pseudomonas, Phoma, Ramularia, Septoria, Venturia, Erysiphaceae, Uredinales and some Seedborne pathogen have lasting protection and therapeutic action.
Oxime bacterium ester (Trifloxystrobin); chemical name: (2Z)-2-methoxyimino-2-[2-[[1-[3-(trifluoromethyl) phenyl] ethyleneimino] oxygen methyl] phenyl] methyl acetate; the new fungicides of a class extracting from natural products Strobilurins, successfully develop as bactericide lead compound, characteristics such as thering is efficient, wide spectrum, protection, treat, root out, infiltration, systemic activity, resistance of rainwater washing against, lasting period are long.Oxime bacterium ester is to Isosorbide-5-Nitrae-demethylation enzyme inhibitor, benzamides, it is effective that dicarboxyl amine and benzimidazole produce the bacterial strain of resistance, with at present existing bactericide without cross resistance; Nearly all Mycophytes (Ascomycetes, Basidiomycetes, Oomycete and Fungi Imperfecti) disease is all had to good activity as powdery mildew, rust, Ying's rot, net blotch, downy mildew, rice blast etc.; Except powdery mildew, leaf spot are had special efficacy, rust, downy mildew, damping off, apple apple scab are had to good activity; Capable of being fast degraded in soil, water because of it, therefore to crop safety, environmentally safe.
Long-term a large amount of use of single bactericide, easily makes disease develop immunity to drugs, and causes dosage increasing, preventive effect reduction, lasting period to shorten, and is unfavorable for environment sustainable development.Delaying disease one of the conventional method that develops immunity to drugs is to carry out composite to the active ingredient of the different mechanisms of action.By lot of experiments, determine best synergistic complex ratio, to expand fungicidal spectrum, improve germicidal efficiency.
Composite preparation taking oxime bacterium ester and Difenoconazole as active component is disclosed in patent CN 102246765 A, CN 102379292 A, CN 103348987 A, but they exist with the form such as aqua, suspending agent, have not yet to see the relevant report of the two water dispersible granules.
Summary of the invention
The object of the present invention is to provide a kind of bactericidal composition containing oxime bacterium ester and Difenoconazole, specifically disclose the formulation of its water dispersible granules, said composition function admirable, bactericidal effect excellence, can avoid disease to develop immunity to drugs, increase the medicine lasting period, be beneficial to environment sustainable development.
The present invention also provides the application of above-mentioned bactericidal composition in control cereal crops, vegetables, fruit diseases.
The present invention is achieved by the following measures:
A kind of bactericidal composition containing oxime bacterium ester and Difenoconazole, it is characterized in that: active constituents of medicine is oxime bacterium ester and Difenoconazole, the weight ratio of oxime bacterium ester and Difenoconazole is 1-10: 1-10, and preferred proportion is 1-5:1-5, and most preferred ratio is 1-2.5:1-2.5.
In above-mentioned bactericidal composition, the content of active constituents of medicine is 30-70wt%, preferably 40-60wt%.
The above-mentioned bactericidal composition containing oxime bacterium ester and Difenoconazole, can be by method known in those skilled in the art, makes the upper any formulation allowing of agricultural, is preferably water dispersible granules.
When composition is made water dispersible granules, the component that comprises following percentage by weight: active constituents of medicine 30%-70%, dispersant 4-10%, wetting agent 2-10%, disintegrant 1-20%, filler surplus.Preferably, composition is made up of the component of following percentage by weight: active constituents of medicine 30%-70%, dispersant 4.5%, wetting agent 2%, disintegrant 12.5%, filler surplus.More preferably formed by the component of following percentage by weight: active constituents of medicine 40%-60%, dispersant 4.5%, wetting agent 2%, disintegrant 12.5%, filler surplus.
Water dispersible granules preparation method is: Difenoconazole, oxime bacterium ester, dispersant, wetting agent, disintegrant, filler are mixed in mixer, after airslide disintegrating mill is crushed to particle diameter 20-40 μ m, mix again, mediate amount of water 20-30wt%, carry out extruder grain, 40-50 DEG C of oven dry, can be made into oxime bacterium ester difenoconazole water dispersible granule product.
Described dispersant is one or more of calcium lignosulfonate, maleic acid-acrylic acid copolymer salt, polyox-yethylene-polyoxypropylene block copolymer, alkylphenol sodium sulfonate, alkyl naphthalene sulfonic acid formaldehyde condensation products sodium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, ethylene oxide-propylene oxide block copolymer and polycarboxylate sodium.Preferred dispersants by polycarboxylate sodium and calcium lignosulfonate in mass ratio 2:1 mix.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, a-sulfo methyl ester, sodium tetradecyl sulfate, neopelex, Negel, a-alkene sulfonic acid sodium, alkyl phenol polyethenoxy ether sodium sulfate, sodium lignin sulfonate, Nekal BX, fatty acid sulphate and fatty acid ester sulphate, preferably wetting agent by lauryl sodium sulfate and sodium lignin sulfonate in mass ratio 1:1 mix.
Described disintegrant is selected from: one or more in potassium sulfate, sodium cellulose glycolate, potassium chloride, diammonium hydrogen phosphate, urea, sodium sulphate, ammonium sulfate, ammonium nitrate, calcium chloride and sodium chloride, preferably disintegrant by ammonium sulfate and urea in mass ratio for 1.5:1 mixes.
Described filler is selected from: one or more in kaolin, bentonite, talcum powder, attapulgite, diatomite, white carbon, starch, precipitated calcium carbonate, preferred filler is white carbon.
Composition of the present invention is mainly used in preventing and treating glume blight, powdery mildew and the scab in the disease in cereal crops, vegetables, fruit tree, especially cereal crops, fruit and vegetables.
Beneficial effect of the present invention: (1) present composition effective active composition oxime bacterium ester and Difenoconazole belong to the bactericide of two kinds of different mechanisms of action, and both mutual mixtures can not produce conflict, and have expanded fungicidal spectrum, improves germicidal efficiency; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little, has avoided the pesticide resistance of disease, has extended the medicine lasting period, is beneficial to environment sustainable development; (3) present composition is made water dispersible granules, has avoided the use of organic solvent, has reduced environmental pollution, is also convenient to the packing of product and transport simultaneously; (4) present composition has special efficacy to the glume blight on cereal crops, vegetables, fruit tree, powdery mildew and scab.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, but the present invention is not limited thereto.If no special instructions, the percentage in following embodiment is all weight percentage.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First pass through Toxicity Determination, synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carry out field trial.
oxime bacterium ester and Difenoconazole are composite to powdery mildew of cucumber bacterium Toxicity Determination
Test medicine provides by Shandong Weifang Rainbow Chemical Co., Ltd..
After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively a series of concentration gradient processing by active constituent content, establishes clear water for contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure the virulence of medicament to powdery mildew of cucumber.After 72h, measure colony diameter by right-angled intersection method, calculate each processing net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) converts logarithm value (x) to, try to achieve virulence regression equation (y=a+bx) with method of least squares, and calculate thus the EC of every kind of medicament
50value.Calculate the different proportioning synergy ratios of two medicaments (SR) according to Wadley method, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein:
A1, b1 are respectively oxime bacterium ester and Difenoconazole shared ratio in combination;
A is oxime bacterium ester;
B is Difenoconazole.
Result of the test is as shown in table 1:
From table 1, oxime bacterium ester, the EC of Difenoconazole to powdery mildew of cucumber
50be respectively 1.346mg/L and 7.397mg/L, the virulence of oxime bacterium ester is apparently higher than the virulence of Difenoconazole.Oxime bacterium ester and Difenoconazole mixture within the scope of 1-10:1-10 all shows synergistic effect, within the scope of 1-5:1-5 synergy more obvious, within the scope of 1-2.5:1-2.5, synergy is the most remarkable.
Lower mask body is enumerated representative embodiment of the present invention.
embodiment 133% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 3%, Difenoconazole 30%, polycarboxylate sodium 3%, calcium lignosulfonate 1.5%, lauryl sodium sulfate 1%, sodium lignin sulfonate 1%, ammonium sulfate 7.5%, urea 5%, white carbon add to 100%.
Preparation method is: Difenoconazole, oxime bacterium ester, dispersant, wetting agent, disintegrant, filler are mixed in mixer, after airslide disintegrating mill is crushed to particle diameter 20-40 μ m, mix again, mediate amount of water 20-30%, carry out extruder grain, 40-50 DEG C of oven dry, can be made into 33% water dispersible granules.
embodiment 254% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 9%, Difenoconazole 45%, polycarboxylate sodium 3%, calcium lignosulfonate 1.5%, lauryl sodium sulfate 1%, sodium lignin sulfonate 1%, ammonium sulfate 7.5%, urea 5%, white carbon add to 100%.Preparation method is with embodiment 1.
embodiment 370% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 20%, Difenoconazole 50%, polycarboxylate sodium 3%, calcium lignosulfonate 1.5%, lauryl sodium sulfate 1%, sodium lignin sulfonate 1%, ammonium sulfate 7.5%, urea 5%, white carbon add to 100%.Preparation method is with embodiment 1.
embodiment 440% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 20%, Difenoconazole 20%, polycarboxylate sodium 3%, calcium lignosulfonate 1.5%, lauryl sodium sulfate 1%, sodium lignin sulfonate 1%, ammonium sulfate 7.5%, urea 5%, white carbon add to 100%.Preparation method is with embodiment 1.
embodiment 556% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 40%, Difenoconazole 16%, polycarboxylate sodium 3%, calcium lignosulfonate 1.5%, lauryl sodium sulfate 1%, sodium lignin sulfonate 1%, ammonium sulfate 7.5%, urea 5%, white carbon add to 100%.Preparation method is with embodiment 1.
embodiment 630% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 25%, Difenoconazole 5%, polycarboxylate sodium 3%, calcium lignosulfonate 1.5%, lauryl sodium sulfate 1%, sodium lignin sulfonate 1%, ammonium sulfate 7.5%, urea 5%, white carbon add to 100%.Preparation method is with embodiment 1.
embodiment 760% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 54.5%, Difenoconazole 5.5%, polycarboxylate sodium 3%, calcium lignosulfonate 1.5%, lauryl sodium sulfate 1%, sodium lignin sulfonate 1%, ammonium sulfate 7.5%, urea 5%, white carbon add to 100%.Preparation method is with embodiment 1.
embodiment 840.7% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 3.7%, Difenoconazole 37%, alkylphenol sodium sulfonate 8%, calcium lignosulfonate 1.5%, lauryl sodium sulfate 1%, sodium lignin sulfonate 1%, potassium sulfate 15%, urea 7%, sodium cellulose glycolate 5%, bentonite add to 100%.Preparation method is with embodiment 1.
embodiment 930.6% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 5.1%, Difenoconazole 25.5%, polycarboxylate sodium 4%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 1.5%, ethylene oxide-propylene oxide block copolymer 2%, lauryl sodium sulfate 1%, a-alkene sulfonic acid sodium 2%, sodium chloride 25%, talcum powder add to 100%.Preparation method is with embodiment 1.
embodiment 1035% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 10%, Difenoconazole 25%, polycarboxylate sodium 3%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 2%, ethylene oxide-propylene oxide block copolymer 2%, lauryl sodium sulfate 1%, a-alkene sulfonic acid sodium 2%, sodium chloride 25%, attapulgite add to 100%.Preparation method is with embodiment 1.
embodiment 1162% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 31%, Difenoconazole 31%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 4%, calcium lignosulfonate 2%, fatty acid ester sulphate 1%, Nekal BX 2%, calcium chloride 22%, bentonite add to 100%.Preparation method is with embodiment 1.
embodiment 1256% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 40%, Difenoconazole 16%, maleic acid-acrylic acid copolymer salt 3%, polyox-yethylene-polyoxypropylene block copolymer 2%, ethylene oxide-propylene oxide block copolymer 1%, fatty acid sulphate 1%, sodium lignin sulfonate 2%, sodium sulphate 20%, starch add to 100%.Preparation method is with embodiment 1.
embodiment 1337.2% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 31%, Difenoconazole 6.2%, calcium lignosulfonate 2%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 2%, ethylene oxide-propylene oxide block copolymer 2%, neopelex 1.5%, a-alkene sulfonic acid sodium 2%, ammonium sulfate 12.5%, diatomite add to 100%.Preparation method is with embodiment 1.
embodiment 1444% oxime bacterium ester difenoconazole water dispersible granule
Formula is: oxime bacterium ester 40%, Difenoconazole 4%, alkyl naphthalene sulfonic acid formaldehyde condensation products sodium salt 3%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 4%, ethylene oxide-propylene oxide block copolymer 2%, sodium tetradecyl sulfate 1%, a-alkene sulfonic acid sodium 2%, potassium chloride 10%, urea 5%, attapulgite add to 100%.Preparation method is with embodiment 1.
Oxime bacterium ester prepared by above-described embodiment and Difenoconazole complex preparation constant product quality are tested, and the results are shown in following table 2.
Data by table 2 can be found out, in embodiment 8,9,10,11,12,13,14, degradation after heat storage, and use the embodiment 1,2,3,4,5,6,7 of preferred promoter before heat storage and after heat storage, quality is all good, and preferred promoter plays key effect in product quality.
effect experiment
1, the oxime bacterium ester of being prepared by above-described embodiment and Difenoconazole complex preparation control wheat glume blight situation are carried out the test of pesticide effectiveness.This experimental establishment is carried out in this locality, and contrast medicament is 50% trifloxystrobin water dispersible granule (commercial), 10% difenoconazole water dispersible granule (commercial).
Test in wheat glume blight their early stage (heading stage), with the spraying of workers and peasants-16 type knapsack hand sprayer cauline leaf, dispenser in every 7 days once, is sprayed medicine three times altogether.Be watered 450kg by per hectare preparation and be equipped with liquid.Dispenser was fine the same day, 23 DEG C of daily mean temperatures, and relative moisture 50%, after medicine, 48h is interior without rainfall.Before dispenser and after dispenser for the third time, within 7 days, investigate the disease number of sheets and disease index, finally calculate control efficiency.
Preventive effect computational methods are:
Above-described check plot is clear water check plot, does not spray medicament.
Duration of test, in test scope of medication, complex preparation of the present invention has no adverse effects to wheat, and experimental result is as follows:
As can be seen from Table 3, after oxime bacterium ester and Difenoconazole are composite, can effectively prevent and treat the generation of wheat glume blight, control efficiency is all better than contrasting medicament.Wherein, use the embodiment preventive effect of preferred promoter and proportioning will obviously be better than other embodiment, and wheat glume blight preventive effect is reached more than 90%; Other embodiment preventive effects, in 80% left and right, are also better than contrasting medicament.
2, the oxime bacterium ester of being prepared by above-described embodiment and Difenoconazole complex preparation control banana freckle situation are carried out the test of pesticide effectiveness, this experimental establishment is in Haikou City, Hainan Province, and contrast medicament is 50% trifloxystrobin water dispersible granule (commercial), 10% difenoconazole water dispersible granule (commercial).
Test in banana freckle their early stage, with the spraying of workers and peasants-16 type knapsack hand sprayer cauline leaf, dispenser in every 7 days once, is total to dispenser 3 times, and dispenser was fine the same day, 27 DEG C of daily mean temperatures, and after medicine, 48h is interior without rainfall.Before dispenser and after dispenser for the third time, within 7 days, investigate the disease number of sheets and disease index, finally calculate control efficiency.
Preventive effect computational methods are as follows:
Above-described check plot is clear water check plot, does not spray medicament.
Duration of test, in test scope of medication, complex preparation of the present invention has no adverse effects to banana, and result of the test is as follows:
As can be seen from Table 4, can effectively prevent and treat the generation of banana freckle after oxime bacterium ester and Difenoconazole are composite, control efficiency is all better than contrasting medicament.Wherein, use the embodiment preventive effect of preferred promoter and proportioning will obviously be better than other embodiment, and banana freckle preventive effect is reached more than 90%; Other embodiment preventive effects, in 80% left and right, are also better than contrasting medicament.
3, oxime bacterium ester, the Difenoconazole complex preparation prepared by above-described embodiment are prevented and treated powdery mildew of cucumber situation and are carried out the test of pesticide effectiveness.This experimental establishment is carried out in locality, and contrast medicament is 50% trifloxystrobin water dispersible granule (commercial), 10% difenoconazole water dispersible granule (commercial).
Test in powdery mildew of cucumber their early stage, with the spraying of workers and peasants-16 type knapsack hand sprayer cauline leaf, dispenser in every 7 days once, is total to dispenser 3 times, and dispenser was fine the same day, 27 DEG C of daily mean temperatures, and after medicine, 48h is interior without rainfall.Before dispenser and after dispenser for the third time, within 7 days, investigate the disease number of sheets and disease index, finally calculate control efficiency.
Preventive effect computational methods are as follows:
Above-described check plot is clear water check plot, does not spray medicament.
Duration of test, in test scope of medication, complex preparation of the present invention has no adverse effects to cucumber, and result of the test is as follows:
Can be found out by table 5, after oxime bacterium ester and Difenoconazole are composite, can effectively prevent and treat the generation of powdery mildew of cucumber, control efficiency is all better than contrasting medicament.Wherein, use the embodiment preventive effect of preferred promoter and proportioning will obviously be better than other embodiment, and powdery mildew of cucumber preventive effect is reached more than 90%; Other embodiment preventive effects, in 80% left and right, are also better than contrasting medicament.
Claims (10)
1. containing a bactericidal composition for oxime bacterium ester and Difenoconazole, it is characterized in that: active constituents of medicine comprises that weight ratio is oxime bacterium ester and the Difenoconazole of 1-10: 1-10.
2. bactericidal composition according to claim 1, is characterized in that: the weight ratio of oxime bacterium ester and Difenoconazole is 1-5:1-5, preferably 1-2.5:1-2.5.
3. bactericidal composition according to claim 1 and 2, is characterized in that: formulation is water dispersible granules.
4. bactericidal composition according to claim 1 and 2, is characterized in that: the content of active constituents of medicine is 30-70wt%, preferably 40-60wt%.
5. bactericidal composition according to claim 3, it is characterized in that: when formulation is water dispersible granules, composition is made up of the component of following percentage by weight: active constituents of medicine 30%-70%, dispersant 4-10%, wetting agent 2-10%, disintegrant 1-20%, filler surplus.
6. bactericidal composition according to claim 5, it is characterized in that: when formulation is water dispersible granules, composition is made up of the component of following percentage by weight: active constituents of medicine 30%-70%, dispersant 4.5%, wetting agent 2%, disintegrant 12.5%, filler surplus.
7. bactericidal composition according to claim 6, it is characterized in that: when formulation is water dispersible granules, composition is made up of the component of following percentage by weight: active constituents of medicine 40%-60%, dispersant 4.5%, wetting agent 2%, disintegrant 12.5%, filler surplus.
8. according to the bactericidal composition described in any one in claim 5-7, it is characterized in that: dispersant by polycarboxylate sodium and calcium lignosulfonate in mass ratio 2:1 mix, wetting agent by lauryl sodium sulfate and sodium lignin sulfonate in mass ratio 1:1 mix, disintegrant is by ammonium sulfate and urea in mass ratio for 1.5:1 mixes, and filler is white carbon.
9. the application of the bactericidal composition containing oxime bacterium ester and Difenoconazole described in any one in control cereal crops, vegetables, fruit diseases in claim 1-8.
10. application according to claim 9, is characterized in that: described disease is glume blight, powdery mildew or scab.
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| US12144342B2 (en) | 2016-05-24 | 2024-11-19 | Adama Makhteshim Ltd. | Oil liquid fungicidal formulation |
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Effective date of registration: 20171116 Address after: No. 8, Hai Pu North Road, New River ecological and chemical technology industry base in Pingdu City, Qingdao, Shandong Patentee after: Qingdao run agricultural chemical Co., Ltd. Address before: Haiyuan Binhai Economic Development Zone, Shandong province Weifang city 262737 Street No. 600 Patentee before: Shandong Weifang Rainbow Chemical Co., Ltd. |