CN103933272A - Liver-protecting, kidney-tonifying and water-disinhibiting traditional Chinese medicine oral liquid for veterinary use and preparation method thereof - Google Patents
Liver-protecting, kidney-tonifying and water-disinhibiting traditional Chinese medicine oral liquid for veterinary use and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a liver-protecting, kidney-tonifying and water-disinhibiting traditional Chinese medicine oral liquid for veterinary use. The traditional Chinese medicine oral liquid is prepared from a traditional Chinese medicine composition and an enzymic preparation. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5-10 parts of monkshood, 10-15 parts of rhizoma alismatis, 10-15 parts of ginseng, 10-15 parts of polygonum cuspidatum, 10-15 parts of capillary artemisia, 10-15 parts of rheum officinale, 10-15 parts of liquorice, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of grifola, 10-15 parts of puerarin and 100-200 parts of water. The traditional Chinese medicine components contained in the oral liquid provided by the invention are subjected to enzymolysis to effectively destroy plant cellulose and pectin substances which prevent medicinal components from dissolving out, thereby greatly improving the effective component extraction efficiency, accelerating the curative effect and improving the effect. Meanwhile, the oral liquid further avoids the defect of chemical medicines which lead to disability and malformation and has the effects of tonifying kidney-yang, tonifying spleen-qi, disinhibiting water-dampness, relieving hepatic toxicity and raising yang-qi.
Description
Technical field
The invention belongs to herbal medicine formulation art, strong kidney diuretic traditional Chinese medicines oral liquid of especially a kind of hepatoprotective for animals and preparation method thereof.
Background technology
Because Chinese medicine processing procedure falls behind, because general plant cell surrounds wall, the film that one deck is made up of materials such as cellulose, cutin, pectic substance, lipids outward, it has great resistivity to general physics, chemical degradation, is the main barrier of active substance macromole stripping in cell.Enzyme engineering technology is a biotechnology of extracting for active ingredient of natural plant in recent years, selects appropriate enzyme, can more leniently plant tissue be decomposed, and accelerates the release of effective ingredient, thereby improves its extraction ratio.Enzyme has biological high-efficiency, a little narrow spectrum simultaneously, and the Chinese crude drug after enzymolysis can obviously reduce extraction temperature and extraction time in leaching process, fully ensures effective substance and is not destroyed.Therefore the medicine of the extraction after enzymolysis has advantages of that curative effect is fast, definite effect.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of good effect, no drug residue, safe and reliable veterinary Chinese medicine oral liquid are provided.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine oral liquid.Simultaneously the present invention also provide a kind of can hepatoprotective, the formula of strong kidney, diuretic.
A Chinese medicine oral liquid for the strong kidney diuretic of hepatoprotective for animals, is made up of Chinese medicine composition and enzyme preparation, counts by weight Chinese medicine composition and comprises following raw material components: Radix Aconiti Lateralis Preparata 5-10 part; Rhizoma Alismatis 10-15 part; Radix Ginseng 10-15 part; Rhizoma Polygoni Cuspidati 10-15 part; Herba Artemisiae Scopariae 10-15 part; Radix Et Rhizoma Rhei 10-15 part; Radix Glycyrrhizae 10-15 part; Rhizoma Atractylodis Macrocephalae 10-15 part; Polyporus 10-15 part; Radix Puerariae 10-15 part; Water 100-200 part.
Above-mentioned enzyme preparation is counted by weight and is comprised following component: cellulase 0.2-0.8 part; Pectase 0.2-0.8 part; Lipase 0.2-0.8 part.
Further preferably, above-mentioned Chinese medicine oral liquid is counted by weight and is comprised following component:
8 parts of Radix Aconiti Lateralis Preparatas; 10 parts of Rhizoma Alismatis; 10 parts of Radix Ginsengs; 10 parts of Rhizoma Polygoni Cuspidati; 10 parts of Herba Artemisiae Scopariaes; 10 parts of Radix Et Rhizoma Rhei; 12 parts, Radix Glycyrrhizae; 10 parts of the Rhizoma Atractylodis Macrocephalaes; 10 parts of Polyporus; 10 parts of Radix Puerariaes; 150 parts, water; 0.4 part of cellulase; 0.4 part of pectase; 0.3 part of lipase.
The extract oral liquid and preparation method thereof of the strong kidney diuretic of a kind of hepatoprotective for animals is:
(1) the each raw material components in described Chinese medicine composition is crushed to 30-50 order, takes by formula ratio, three-dimensional hybrid obtains Chinese medicine powder;
(2) mixed Chinese medicine powder, cellulase, pectase, lipase, water are put in extraction pot in proportion, at 35-50 DEG C, pH3-8 constant temperature hydrolysis 10-60 minute;
(3) hydrolyzed solution is heated to 60-100 DEG C and extracts 1-5 hour;
(4) remove by filter medicinal residues, the direct fill of liquid get product.
In the listed Chinese medicine composition of the present invention, each raw material of Chinese medicine pharmacology is:
Radix Aconiti Lateralis Preparata: warming the kidney to invigorate YANG, heart tonifying diuretic.
Rhizoma Alismatis: promoting diuresis to eliminate damp pathogen.
Radix Ginseng: strongly invigorating primordial QI, promote the production of body fluid Gu de-, calm the nerves.
The Rhizoma Atractylodis Macrocephalae: the spleen strengthening and damp drying, in and diuretic.
Radix Glycyrrhizae: spleen invigorating QI invigorating, heat-clearing and toxic substances removing, relieving cough and resolving phlegm, the mediation property of medicine.
Rhizoma Polygoni Cuspidati: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.
Radix Puerariae: hepatoprotective, yang invigorating, removing toxic substances.
Herba Artemisiae Scopariae: clearing away heat-damp and promoting diuresis, jaundice eliminating.
Radix Et Rhizoma Rhei: heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
Polyporus: spleen invigorating, eliminating dampness by diuresis, diuresis.
During among described Chinese medicine composition composition formula, Radix Ginseng, Rhizoma Atractylodis Macrocephalae QI invigorating are protected, invigorating the spleen and benefiting QI.Simultaneously Radix Ginseng is joined the Radix Aconiti Lateralis Preparata invigorating middle warmer gas heart tonifying of holding concurrently.Increase cardiac contractile force, improve resistance, reduce mortality rate.Rhizoma Alismatis is joined the simultaneously clear diuretic of Rhizoma Atractylodis Macrocephalae spleen invigorating and wets, and holds trusted subordinate's distension, all cards of cutting off the water under the heart in the diseases caused by retention of fluid that minimizing deficiency-cold in middle-JIAO causes.Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis, remove the damp and hot of liver and gall alluvials, makes damp and hot going and liver and gall are dredged sharply, eliminates fast the liver and gall of swelling.Polyporus is joined Rhizoma Alismatis and strengthens the effect that diuretic leads to kidney, and contained polysaccharide can improve poultry nonspecific immunity simultaneously.Radix Puerariae is eliminated the Fibrotic hepatocyte of swelling fast, accelerates hepatocyte repair ability, improves the removing ability of liver to vivotoxin.Radix Glycyrrhizae can coordinating the actions of various ingredients in a prescription, reduces the property that each medicine is sent an expedition against mutually.
Advantage of the present invention and beneficial effect are:
1, the Chinese medicine composition adopting is according to tcm theory, science compatibility, retain the combined effect of Chinese medicinal formulae determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and use modern means of science and technology to the effective ingredient of most of medical material wherein carry out quantitatively, half-quantitative detection, through clinical verification determined curative effect, it is a kind of green veterinary drug with the strong kidney diuretic of hepatoprotective of nuisanceless no drug residue.
2, the Chinese medicine ingredients that the present invention contains is after the quantitative complex enzyme hydrolysis of three kinds of enzyme preparation cellulase, pectase, lipase, can effectively destroy the plant cellulose, Vegetable oil lipoprotein and the pectic substance that hinder medicinal ingredient stripping, increase substantially the abundant stripping of medicinal ingredient and extract, as table 1-1; Also the effect that has speed-raising curative effect and improve drug effect as table 1-2 simultaneously; And also avoid the teratogenesis defect that disables of chemicals, there is the effect that kidney-replenishing, spleen invigorating gas, diuretic are wet, separate liver poison, yang invigorating gas.
The contrast of ratio in advance of each effective ingredient that table 1-1 obtains by the cited method of the present invention and general preparation method for each Chinese medicinal components in the present invention, contrast can be regarded the listed method of the present invention as and increased substantially the rate in advance of medicinal ingredient.
Table 1-1
Table 1-2 is for using the present invention: Radix Aconiti Lateralis Preparata 8g; Rhizoma Alismatis 10g; Radix Ginseng 10g; Rhizoma Polygoni Cuspidati 10g; Herba Artemisiae Scopariae 10g; Radix Et Rhizoma Rhei 10g; Radix Glycyrrhizae 12g; Rhizoma Atractylodis Macrocephalae 10g; Polyporus 10g; Radix Puerariae 10g; Water 150g; Cellulase 0.4g; Pectase 0.4g; Lipase 0.3g, the contrast experiment who is undertaken by preparation method that the present invention lifts acquisition Chinese medicine oral liquid and traditional method for extracting gains; By contrast can see, use the present invention obtain Chinese medicine oral liquid can raise speed curative effect and improve drug effect; Also avoid the teratogenesis defect that disables of chemicals simultaneously, there is the effect that kidney-replenishing, spleen invigorating gas, diuretic are wet, separate liver poison, yang invigorating gas.
Table 1-2
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1:
A Chinese medicine oral liquid for the strong kidney diuretic of hepatoprotective for animals, each raw material components and weight thereof respectively:
Radix Aconiti Lateralis Preparata: 8g; Rhizoma Alismatis: 10g; Radix Ginseng: 10g; Rhizoma Polygoni Cuspidati: 10g; Herba Artemisiae Scopariae: 10g; Radix Et Rhizoma Rhei: 10g; Radix Glycyrrhizae:
12g; The Rhizoma Atractylodis Macrocephalae: 10g; Polyporus: 10g; Radix Puerariae 10g; Water: 150g; Cellulase: 0.4g; Pectase 0.4g;
Lipase 0.3g.
Its preparation method is:
(1) above-mentioned Chinese medicine powder is broken to 45 orders, takes by formula ratio, three-dimensional hybrid obtains Chinese medicine powder;
(2) mixed Chinese medicine powder, cellulase, pectase, lipase, water are put in extraction pot, at 37 DEG C,
PH6 constant temperature hydrolysis 40 minutes;
(3) hydrolyzed solution being heated to 90 DEG C extracts 4 hours;
(4) remove by filter medicinal residues, the direct fill of liquid (every bottle of 100ml) get product.
Jiangsu chicken house, 200,000 of breeding stocks, fall ill 60,000, are diagnosed as ascites syndrome through cuing open inspection.Wherein 30,000 use the obtained product of embodiment 1.Drink water 300 jin, treat 3 days for every bottle.Second day symptom of medication obviously alleviates, and within the 3rd day, except indivedual mixed sense serious symptoms, jumpbogroup is cured.Cure rate reaches 93.8%.This Chinese medicine oral liquid of another 20,000 non-enzymolysis of use, treats 5 days, and the 3rd day starts to take effect, and within the 5th day, jumpbogroup is cured, cure rate 75.6%.Another ten thousand use the conventional treatment in market ascites syndrome cured substance rate 60.5%.Experimental results show that the obtained product curative effect of embodiment 1 is obviously better than other similar drugs.
Embodiment 2:
A Chinese medicine oral liquid for the strong kidney diuretic of hepatoprotective for animals, each raw material components and weight thereof respectively:
Radix Aconiti Lateralis Preparata 10g; Rhizoma Alismatis 15g; Radix Ginseng 15g; Rhizoma Polygoni Cuspidati 15g; Herba Artemisiae Scopariae 15g; Radix Et Rhizoma Rhei 15g; Radix Glycyrrhizae 15g; Rhizoma Atractylodis Macrocephalae 15g; Polyporus 15g; Radix Puerariae 15g; Water 200g, cellulase 0.8g; Pectase 0.8g; Lipase 0.6g.
Its preparation method is:
(1) above-mentioned Chinese medicine powder is broken to 40 orders, takes by formula ratio, three-dimensional hybrid obtains Chinese medicine powder;
(2) mixed Chinese medicine powder, cellulase, pectase, lipase, water are put in extraction pot, at 37 DEG C,
PH6 constant temperature hydrolysis 40 minutes;
(3) hydrolyzed solution being heated to 90 DEG C extracts 4 hours;
(4) remove by filter medicinal residues, the direct fill of liquid (every bottle of 100ml) get product.
Shandong Mou Huhe plant, 30,000 of breeding stocks, fall ill 5,000, are diagnosed as hepatic ascites disease through cuing open inspection.Wherein 2,000 use the obtained product of embodiment 2.200 jin of every bottle of spices, treat 3 days.Second day symptom of medication obviously alleviates, and within the 3rd day, except indivedual mixed sense serious symptoms, jumpbogroup is cured.Cure rate reaches 83.2%.Another 2,000 use non-enzymolysis Chinese medicine oral liquid, treat 5 days, and the 4th day starts to take effect, and within the 5th day, jumpbogroup is cured, cure rate 75.6%.Another thousand use the conventional treatment in market hepatic ascites cured substance rate 53.2%.Experimental results show that the obtained product curative effect of embodiment 2 is obviously better than other similar drugs.
Above preferred embodiment of the present invention is had been described in detail, but described content is only preferred embodiment of the present invention, can not be considered to for limiting practical range of the present invention.All equalization variation and improvement etc. of doing according to the present patent application scope, within all should still belonging to patent covering scope of the present invention.
Claims (4)
1. the strong kidney diuretic traditional Chinese medicines oral liquid of hepatoprotective for animals, its feature is being made up of Chinese medicine composition and enzyme preparation, wherein counts by weight Chinese medicine composition and comprises following raw material components: Radix Aconiti Lateralis Preparata 5-10 part; Rhizoma Alismatis 10-15 part; Radix Ginseng 10-15 part; Rhizoma Polygoni Cuspidati 10-15 part; Herba Artemisiae Scopariae 10-15 part; Radix Et Rhizoma Rhei 10-15 part; Radix Glycyrrhizae 10-15 part; Rhizoma Atractylodis Macrocephalae 10-15 part; Polyporus 10-15 part; Radix Puerariae 10-15 part; Water 100-200 part.
2. Chinese medicine oral liquid according to claim 1, is characterized in that described enzyme preparation is counted by weight and comprises following component: cellulase 0.2-0.8 part; Pectase 0.2-0.8 part; Lipase 0.2-0.8 part.
3. Chinese medicine oral liquid according to claim 2, is characterized in that counting by weight, comprises following raw material components: 8 parts of Radix Aconiti Lateralis Preparatas; 10 parts of Rhizoma Alismatis; 10 parts of Radix Ginsengs; 10 parts of Rhizoma Polygoni Cuspidati; 10 parts of Herba Artemisiae Scopariaes; 10 parts of Radix Et Rhizoma Rhei; 12 parts, Radix Glycyrrhizae; 10 parts of the Rhizoma Atractylodis Macrocephalaes; 10 parts of Polyporus; 10 parts of Radix Puerariaes; 150 parts, water; 0.4 part of cellulase; 0.4 part of pectase; 0.3 part of lipase.
4. a preparation method for the Chinese medicine oral liquid as described in claim 1-3 any one, is characterized in that being made up of following steps: (1) each described Chinese medicine composition raw material components is crushed to 30-50 order, takes by formula ratio, three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, cellulase, pectase, lipase, water are put in extraction pot in proportion, at 35-50 DEG C, pH3-8 constant temperature hydrolysis 10-60 minute; (3) hydrolyzed solution is heated to 60-100 DEG C and extracts 1-5 hour; (4) remove by filter medicinal residues, the direct fill of liquid get product.
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| CN201410164534.8A CN103933272B (en) | 2014-04-22 | 2014-04-22 | A kind of protect liver for animals is good for kidney Li Shui traditional Chinese medicine oral liquid and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106260670A (en) * | 2016-09-30 | 2017-01-04 | 安徽华澳生物技术有限公司 | A kind of feed additive preventing and treating pig erysipelas |
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2014
- 2014-04-22 CN CN201410164534.8A patent/CN103933272B/en active Active
Non-Patent Citations (4)
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| 兰艳霞等: "益气健肾解毒利水汤治疗蛋白尿", 《实用中医内科杂志》 * |
| 刘钟杰等: "《中兽医学》", 30 June 2011, 中国农业出版社 * |
| 纪学慧等: "酶技术在中药成分提取分离中的应用", 《中华中医药学刊》 * |
| 马小娟等: "加味茵陈五苓散对免疫性肝损伤保护作用及其机理研究", 《时珍国医国药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106260670A (en) * | 2016-09-30 | 2017-01-04 | 安徽华澳生物技术有限公司 | A kind of feed additive preventing and treating pig erysipelas |
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