CN103918963B - Royal jelly oral liquid with liver-protecting effect - Google Patents
Royal jelly oral liquid with liver-protecting effect Download PDFInfo
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- CN103918963B CN103918963B CN201410170645.XA CN201410170645A CN103918963B CN 103918963 B CN103918963 B CN 103918963B CN 201410170645 A CN201410170645 A CN 201410170645A CN 103918963 B CN103918963 B CN 103918963B
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention provides royal jelly oral liquid with a liver-protecting effect. The royal jelly oral liquid comprises the following raw materials in parts by weight: 60-80 parts of a traditional Chinese medicine composition extracting solution, 100-120 parts of royal jelly, 60-80 parts of honey and 140-160 parts of white sugar. According to the oral liquid, the royal jelly and the traditional Chinese medicine ingredients are combined to achieve a good liver-protecting effect, and the royal jelly oral liquid is a good health-care product and has a great benefit to physical health of people who drink for a long time.
Description
Technical field
The present invention relates to health product technology field, particularly relate to a kind of royal jelly liquid with liver protection effect.
Background technology
Royal jelly is also royal jelly, is a kind of milky substance of thickness of honeybee Worker head glandulae pharyngeae secretion, color from milky to faint yellow not etc.Modern medicine study shows, royal jelly be a kind of well anti-ageing, antimicrobial, antitumor, strengthen immunity health food and cosmetology good merchantable brand.Royal jelly always is natural nutritional supplement, and its effect is varied, and does not find that royal jelly has any murder by poisoning and toxic and side effect so far.Along with the development of modern science and technology, the range of application of royal jelly expands medical treatment, food, cosmetic, the industry such as daily to.
The main component Dou Shi animal tissue organ growth of royal jelly grows necessary nutriment, and these materials are easy to absorb, and all can be immediately used by the body, therefore royal jelly is the good merchantable brand of nourishing and fit keeping function.The ratio of the comprehensive nutritional labeling of royal jelly and equilibrium makes it become focus in field of health care products, can be used to the health foods such as making is anti-ageing, radioresistance, raising immunity, for the staff under the elderly, high Radiation work condition and sportsman etc.Royal jelly has unique physiological function, can human body sub-health status be improved, improve a poor appetite, improving water flood, raising memory, make people energetic.For the elderly, royal jelly can make memory and eyesight improve, and to artery sclerosis, narrow myocarditis, ulcer with in poor healthly all have good efficacy, can strengthen metabolism and hematopoiesis function, improve immunity, all have curative effect in various degree for anaemia, leukopenia etc.
The damage of royal jelly to hepatic tissue has repair, can promote hepatocellular regeneration, can also strengthen and improve the function of detoxification of liver.Also containing abundant amino acid in royal jelly, wherein having multiple is cerebral neurotransmitters, can suppress or excited brain cell, thus the balance of mediator's somatic nervous system effectively, eliminate sleep-disorder rapidly.In addition, containing promoting sexual gland hormone in royal jelly, can the property strengthened function.Royal jelly also has effect of cosmetology, can promote the elimination of facial wrinkles, acne, prevent pigment deposition.
Alcoholic liver injury belongs to common clinical, is the liver damage because long-term excessive consumption of alcohol causes, comprises alcoholic fatty liver, alcoholic hepatitis, alcoholic fibrosis, alcoholic cirrhosis, and this several form separately or can mix existence.Along with the raising of living standards of the people, popularity of wine is increasing year by year, and alcoholic liver injury will become the another major disease of harm national health, and modern medicine is deepening continuously to the understanding of alcoholic liver injury and research.In the time-honored China of spirits culture, people are also deep gradually to the understanding of wine and wine disease in practice, have many records about wine and wine disease in ancient literature.
Though the title of traditional Chinese medicine alcohol-free property hepatic injury, according to its cause of disease, pathology and Clinical symptoms, can be belonged among the disease such as " getting sick from drinking too much wine ", " wine subcutaneous ulcer ", " alcoholophilia ", " hypochondriac pain ", " gathering ", " wine drum ", " water is dim ".Generally speaking, alcoholic fatty liver, alcoholic hepatitis can be controlled by the opinion such as " getting sick from drinking too much wine ", " hypochondriac pain ", " alcoholophilia ", alcoholic cirrhosis then the belongs to sick category such as " alcoholophilia ", " wine is dim ".
Long-term excessive consumption of alcohol, the damp and hot heresy of wine poison is pented up in body, and damage liver spleen, causes the catharsis of liver and the transportation capabilities of spleen neglect one's dutys, stagnation of liver-QI with deficiency of the spleen, and qi and blood is got along well, the turbid interior life of phlegm, and qi and blood phlegm wetting phase is fought knot mutually, and under being stopped at the side of body, block is amassed in formation.Delay with the passing of time, the dirty all damages of liver spleen kidney three and functional disturbance, qi and blood water tie mutually form dim swollen.
Wine poison is the basic reason of alcoholic liver injury, and ferritic enjoys that to compose not enough, weakness of the spleen and the stomach be the basis of its morbidity, and its interpretation of the cause, onset and process of an illness develops and first injures liver spleen, and the later stage involves in kidney, and formed with gas, blood, water closely related, this is its basic pathogenesis place.
The present invention is based on theory of traditional Chinese medical science, a kind of royal jelly liquid health products for having liver protection effect in alcoholic liver injury process are provided, by by royal jelly and Chinese medicine adding ingredient conbined usage, realize good liver protection effect, be a kind of good health products, the health for the people of long-term alcohol is of great advantage.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of royal jelly with liver protection effect, it passes through royal jelly and Chinese medicine adding ingredient conbined usage, realize good liver protection effect, be a kind of good health products, the health for the people of long-term alcohol is of great advantage.
For solving the problems of the technologies described above, the invention provides a kind of royal jelly liquid with liver protection effect, its raw material comprises traditional Chinese medicine composition extract liquid 60 weight portion ~ 80 weight portion, royal jelly 100 weight portion ~ 120 weight portion, honey 60 weight portion ~ 80 weight portion and white sugar 140 weight portion ~ 160 weight portion.
Wherein, the bulk drug of described traditional Chinese medicine composition extract liquid comprises radix bupleuri, the red sage root, oriental wormwood, wilsonii, eclipta, hawthorn, the root of kudzu vine, oldenlandia diffusa, stringy stonecrop, the radix paeoniae rubrathe, the bighead atractylodes rhizome, radix pseudostellariae, saline cistanche, Gorgon fruit, dioscoreae septemlobae,rhizoma, dragon-boat flower, Radix Liriopes, Rabdosia rubescens, Commeline communis, the stem of noble dendrobium, Fructus Corni, parasitic loranthus and Radix Glycyrrhizae.
Wherein, in described traditional Chinese medicine composition extract liquid, the weight portion of each bulk drug is respectively radix bupleuri 35 weight portion ~ 45 weight portion, the red sage root 20 weight portion ~ 30 weight portion, oriental wormwood 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, eclipta 30 weight portion ~ 40 weight portion, hawthorn 25 weight portion ~ 35 weight portion, the root of kudzu vine 20 weight portion ~ 30 weight portion, oldenlandia diffusa 15 weight portion ~ 25 weight portion, stringy stonecrop 20 weight portion ~ 30 weight portion, the radix paeoniae rubrathe 20 weight portion ~ 30 weight portion, the bighead atractylodes rhizome 35 weight portion ~ 45 weight portion, radix pseudostellariae 40 weight portion ~ 50 weight portion, saline cistanche 35 weight portion ~ 45 weight portion, Gorgon fruit 25 weight portion ~ 35 weight portion, dioscoreae septemlobae,rhizoma 15 weight portion ~ 25 weight portion, 5 weight portion ~ 15 weight portions spent by dragon-boat, Radix Liriopes 20 weight portion ~ 30 weight portion, Rabdosia rubescens 25 weight portion ~ 35 weight portion, Commeline communis 20 weight portion ~ 30 weight portion, the stem of noble dendrobium 25 weight portion ~ 35 weight portion, Fructus Corni 35 weight portion ~ 45 weight portion, parasitic loranthus 25 weight portion ~ 35 weight portion and Radix Glycyrrhizae 20 weight portion ~ 30 weight portion.
Wherein, in described traditional Chinese medicine composition extract liquid, the weight portion of each bulk drug is respectively radix bupleuri 40 weight portion ~ 45 weight portion, the red sage root 25 weight portion ~ 30 weight portion, oriental wormwood 30 weight portion ~ 35 weight portion, wilsonii 40 weight portion ~ 45 weight portion, eclipta 35 weight portion ~ 40 weight portion, hawthorn 30 weight portion ~ 35 weight portion, the root of kudzu vine 25 weight portion ~ 30 weight portion, oldenlandia diffusa 20 weight portion ~ 25 weight portion, stringy stonecrop 25 weight portion ~ 30 weight portion, the radix paeoniae rubrathe 25 weight portion ~ 30 weight portion, the bighead atractylodes rhizome 40 weight portion ~ 45 weight portion, radix pseudostellariae 45 weight portion ~ 50 weight portion, saline cistanche 40 weight portion ~ 45 weight portion, Gorgon fruit 30 weight portion ~ 35 weight portion, dioscoreae septemlobae,rhizoma 15 weight portion ~ 20 weight portion, 5 weight portion ~ 10 weight portions spent by dragon-boat, Radix Liriopes 20 weight portion ~ 25 weight portion, Rabdosia rubescens 25 weight portion ~ 30 weight portion, Commeline communis 20 weight portion ~ 25 weight portion, the stem of noble dendrobium 25 weight portion ~ 30 weight portion, Fructus Corni 35 weight portion ~ 40 weight portion, parasitic loranthus 25 weight portion ~ 30 weight portion and Radix Glycyrrhizae 20 weight portion ~ 25 weight portion.
Wherein, in described traditional Chinese medicine composition extract liquid, the weight portion of each bulk drug is respectively radix bupleuri 40 weight portion, the red sage root 25 weight portion, oriental wormwood 30 weight portion, wilsonii 40 weight portion, eclipta 35 weight portion, hawthorn 30 weight portion, the root of kudzu vine 25 weight portion, oldenlandia diffusa 20 weight portion, stringy stonecrop 25 weight portion, the radix paeoniae rubrathe 25 weight portion, the bighead atractylodes rhizome 40 weight portion, radix pseudostellariae 45 weight portion, saline cistanche 40 weight portion, Gorgon fruit 30 weight portion, dioscoreae septemlobae,rhizoma 20 weight portion, 10 weight portions spent by dragon-boat, Radix Liriopes 25 weight portion, Rabdosia rubescens 30 weight portion, Commeline communis 25 weight portion, the stem of noble dendrobium 30 weight portion, Fructus Corni 40 weight portion, parasitic loranthus 30 weight portion and Radix Glycyrrhizae 25 weight portion.
There is described in present invention also offers the preparation method of the royal jelly liquid of liver protection effect, be specially:
The first step, the preparation of traditional Chinese medicine composition extract liquid;
Second step, by royal jelly and honey mixing, homogeneous with homogenizer;
3rd step, is dissolved in white sugar in drinking water, is stirred to white sugar and dissolves completely, and filter, filtrate is for subsequent use;
4th step, the refined sugar solution mixing of the royal jelly that the traditional Chinese medicine composition extract liquid first step obtained, second step obtain and the mixed liquor that honey mixing is formed and the acquisition of the 3rd step, obtain mixed solution, add isopyknic drinking water with mixed solution, boil 20 ~ 40 minutes, let cool to room temperature, filter with 0.25 μm ~ 0.65 μm membrane filter, be filled in tubetype glass bottle, gland seal, with 100 ~ 110 DEG C of steam sterilizings 10 ~ 30 minutes, obtain royal jelly liquid.
Wherein, the preparation method of described traditional Chinese medicine composition extract liquid is specially:
Above-mentioned raw materials medicine component is pulverized respectively, mix in proportion, obtain mixture, put into multi-function extractor, add distilled water, the volume that every 1kg mixture adds distilled water is 3 ~ 5L, first soak 30min ~ 1h, decoct 2h ~ 3h again, the decoction liquor obtained is filtered, obtain the first filtrate, again distilled water is added in filter residue, the volume adding distilled water in every 1kg filter residue is 2 ~ 4L, decoct 2h ~ 3h again, the decoction liquor obtained is filtered again, obtain filtrate, filtrate is merged, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration remove portion water, obtaining crude drug concentration is the solution of 1g/ml.
Beneficial effect of the present invention:
Royal jelly liquid provided by the invention passes through royal jelly and Chinese medicine adding ingredient conbined usage, and realize good liver protection effect, be a kind of good health products, the health for the people of long-term alcohol is of great advantage.
Detailed description of the invention
The invention provides a kind of royal jelly liquid with liver protection effect, its raw material comprises traditional Chinese medicine composition extract liquid 60 weight portion ~ 80 weight portion, royal jelly 100 weight portion ~ 120 weight portion, honey 60 weight portion ~ 80 weight portion and white sugar 140 weight portion ~ 160 weight portion.
Further, the weight portion of described each raw material is specially traditional Chinese medicine composition extract liquid 70 weight portion, royal jelly 110 weight portion, honey 70 weight portion and white sugar 150 weight portion.
Further, described royal jelly liquid is only made up of above-mentioned raw materials.
The described preparation method with the royal jelly liquid of liver protection effect, is specially:
The first step, the preparation of traditional Chinese medicine composition extract liquid;
Second step, by royal jelly and honey mixing, homogeneous with homogenizer;
3rd step, is dissolved in white sugar in drinking water, is stirred to white sugar and dissolves completely, and filter, filtrate is for subsequent use;
4th step, the refined sugar solution mixing of the royal jelly that the traditional Chinese medicine composition extract liquid first step obtained, second step obtain and the mixed liquor that honey mixing is formed and the acquisition of the 3rd step, obtain mixed solution, add isopyknic drinking water with mixed solution, boil 20 ~ 40 minutes, let cool to room temperature, filter with 0.25 μm ~ 0.65 μm membrane filter, be filled in tubetype glass bottle, gland seal, with 100 ~ 110 DEG C of steam sterilizings 10 ~ 30 minutes, obtain royal jelly liquid.
The bulk drug of described traditional Chinese medicine composition extract liquid comprises radix bupleuri, the red sage root, oriental wormwood, wilsonii, eclipta, hawthorn, the root of kudzu vine, oldenlandia diffusa, stringy stonecrop, the radix paeoniae rubrathe, the bighead atractylodes rhizome, radix pseudostellariae, saline cistanche, Gorgon fruit, dioscoreae septemlobae,rhizoma, dragon-boat flower, Radix Liriopes, Rabdosia rubescens, Commeline communis, the stem of noble dendrobium, Fructus Corni, parasitic loranthus and Radix Glycyrrhizae.
Further, described traditional Chinese medicine composition extract liquid is only made up of above-mentioned raw materials medicine.
In described traditional Chinese medicine composition extract liquid, the weight portion of each bulk drug is respectively radix bupleuri 35 weight portion ~ 45 weight portion, the red sage root 20 weight portion ~ 30 weight portion, oriental wormwood 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, eclipta 30 weight portion ~ 40 weight portion, hawthorn 25 weight portion ~ 35 weight portion, the root of kudzu vine 20 weight portion ~ 30 weight portion, oldenlandia diffusa 15 weight portion ~ 25 weight portion, stringy stonecrop 20 weight portion ~ 30 weight portion, the radix paeoniae rubrathe 20 weight portion ~ 30 weight portion, the bighead atractylodes rhizome 35 weight portion ~ 45 weight portion, radix pseudostellariae 40 weight portion ~ 50 weight portion, saline cistanche 35 weight portion ~ 45 weight portion, Gorgon fruit 25 weight portion ~ 35 weight portion, dioscoreae septemlobae,rhizoma 15 weight portion ~ 25 weight portion, 5 weight portion ~ 15 weight portions spent by dragon-boat, Radix Liriopes 20 weight portion ~ 30 weight portion, Rabdosia rubescens 25 weight portion ~ 35 weight portion, Commeline communis 20 weight portion ~ 30 weight portion, the stem of noble dendrobium 25 weight portion ~ 35 weight portion, Fructus Corni 35 weight portion ~ 45 weight portion, parasitic loranthus 25 weight portion ~ 35 weight portion and Radix Glycyrrhizae 20 weight portion ~ 30 weight portion.
Further, in described traditional Chinese medicine composition extract liquid, the weight portion of each bulk drug is respectively radix bupleuri 40 weight portion ~ 45 weight portion, the red sage root 25 weight portion ~ 30 weight portion, oriental wormwood 30 weight portion ~ 35 weight portion, wilsonii 40 weight portion ~ 45 weight portion, eclipta 35 weight portion ~ 40 weight portion, hawthorn 30 weight portion ~ 35 weight portion, the root of kudzu vine 25 weight portion ~ 30 weight portion, oldenlandia diffusa 20 weight portion ~ 25 weight portion, stringy stonecrop 25 weight portion ~ 30 weight portion, the radix paeoniae rubrathe 25 weight portion ~ 30 weight portion, the bighead atractylodes rhizome 40 weight portion ~ 45 weight portion, radix pseudostellariae 45 weight portion ~ 50 weight portion, saline cistanche 40 weight portion ~ 45 weight portion, Gorgon fruit 30 weight portion ~ 35 weight portion, dioscoreae septemlobae,rhizoma 15 weight portion ~ 20 weight portion, 5 weight portion ~ 10 weight portions spent by dragon-boat, Radix Liriopes 20 weight portion ~ 25 weight portion, Rabdosia rubescens 25 weight portion ~ 30 weight portion, Commeline communis 20 weight portion ~ 25 weight portion, the stem of noble dendrobium 25 weight portion ~ 30 weight portion, Fructus Corni 35 weight portion ~ 40 weight portion, parasitic loranthus 25 weight portion ~ 30 weight portion and Radix Glycyrrhizae 20 weight portion ~ 25 weight portion.
Most preferably, in described traditional Chinese medicine composition extract liquid, the weight portion of each bulk drug is respectively radix bupleuri 40 weight portion, the red sage root 25 weight portion, oriental wormwood 30 weight portion, wilsonii 40 weight portion, eclipta 35 weight portion, hawthorn 30 weight portion, the root of kudzu vine 25 weight portion, oldenlandia diffusa 20 weight portion, stringy stonecrop 25 weight portion, the radix paeoniae rubrathe 25 weight portion, the bighead atractylodes rhizome 40 weight portion, radix pseudostellariae 45 weight portion, saline cistanche 40 weight portion, Gorgon fruit 30 weight portion, dioscoreae septemlobae,rhizoma 20 weight portion, 10 weight portions spent by dragon-boat, Radix Liriopes 25 weight portion, Rabdosia rubescens 30 weight portion, Commeline communis 25 weight portion, the stem of noble dendrobium 30 weight portion, Fructus Corni 40 weight portion, parasitic loranthus 30 weight portion and Radix Glycyrrhizae 25 weight portion.
Present invention also offers the preparation method of above-mentioned traditional Chinese medicine composition extract liquid, be specially:
Above-mentioned raw materials medicine component is pulverized respectively, mix in proportion, obtain mixture, put into multi-function extractor, add distilled water, the volume that every 1kg mixture adds distilled water is 3 ~ 5L, first soak 30min ~ 1h, decoct 2h ~ 3h again, the decoction liquor obtained is filtered, obtain the first filtrate, again distilled water is added in filter residue, the volume adding distilled water in every 1kg filter residue is 2 ~ 4L, decoct 2h ~ 3h again, the decoction liquor obtained is filtered again, obtain filtrate, filtrate is merged, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration remove portion water, obtaining crude drug concentration is the solution of 1g/ml.
The pharmacology of described each bulk drug is as follows:
Radix bupleuri: bitter, cold nature, returns liver, gallbladder channel, has evacuation and brings down a fever, and rises effect of the easypro liver of sun, cures mainly cold, fever, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, the cards such as uterus comes off, irregular menstruation.
The red sage root: bitter, cold nature, the thoughts of returning home, Liver Channel, have promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, and cool blood disappears carbuncle, and clear away heart-fire relieving restlessness, and effect of nourishing blood and tranquilization, cures mainly irregular menstruation, and through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, hot numbness pain, and sore swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.
The cards such as oriental wormwood: taste is pungent, bitter, cold nature, returns spleen, stomach, liver, gallbladder channel, cure mainly jaundice, difficult urination, wet sore itch, pharmaceutical research has cholagogic, liver function protecting, antipyretic, anti-inflammatory, reducing blood lipid, step-down, expands the effects such as hat.
Wilsonii: taste is pungent, bitter, micro-sweet, warm in nature, enters spleen, kidney, the heart channel of Hang-Shaoyin, have and replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, the effect of dispelling rheumatism, soft for wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, be slow in action, the card such as body void is thin and weak, traumatic injury, fracture, oedema, beriberi, uncontrolled urination are itched.
Eclipta: taste is sweet, sour, cold in nature, returns liver, kidney channel, plays and tonify the liver and kidney, the effect of cooling blood and hemostasis, for having a dizzy spell caused by the deficiency of liver-yin and kidney-yin, blurring of vision, and soreness and weakness of waist and knees; Be suitable for the deficiency of Yin and have hot person, be used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of heat impairing pulmonary collateral.
Hawthorn: taste acid, property is put down, and returns Liver Channel, has promoting blood circulation and removing blood stasis, regulate the flow of vital energy and promote blood circulation, change effect of turbid lipopenicillinase, cure mainly qi depression to blood stasis, chest impediment and cardialgia, chest distress, palpitation and amnesia, dizzy tinnitus, the cards such as hyperlipemia.
The root of kudzu vine: taste is sweet, pungent, cool in nature, enter spleen, stomach warp, have inspiration stomach Qi, clearing heat and promoting fluid, expelling pathogenic factors from muscles and skin is delivered, and raw sun, oozes the effect of rash, be mainly used in fever caused by exogenous pathogens, headache, stiff nape and back, and pyreticosis is thirsty, quenches one's thirst; Splenasthenic diarrhea, the cards such as lucid yang failing to raise.
Oldenlandia diffusa: bitter, sweet, cold in nature, enters the heart, liver, spleen, large intestine channel, has clearing heat and detoxicating, the effect of clearing damp and promoting diuresis, for dyspnea and cough due to lung-heat, abscess of throat, acute appendicitis, furuncle sore, venomous snake bite, heat drenches puckery pain, oedema, dysentery, enteritis, jaundice with damp-heat pathogen, the cards such as cancerous swelling.
Stringy stonecrop: taste is sweet, light, cool in nature, returns liver, courage, small intestinl channel, has eliminating dampness and heat, and effect of removing toxic substances, cures mainly jaundice with damp-heat pathogen, difficult urination, and carbuncle swells the cards such as sore, acute hepatitis, chronic hepatitis, and stringy stonecrop has the effect protecting liver and immunity.
The radix paeoniae rubrathe: bitter, cold nature, enters Liver Channel, has clearing heat and cooling blood, the effect of blood stasis removing analgesic, and for febrile virulent maculae, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, through closing dysmenorrhoea, abdominal mass is suffered from abdominal pain, injury from falling down, and carbuncle swells the cards such as sore.
The bighead atractylodes rhizome: bitter, sweet, warm in nature, enter spleen, stomach warp, there is strengthening the spleen and replenishing qi, eliminating dampness Li Shui, strengthening exterior and reducing sweat, antiabortive effect, for weakness of the spleen and the stomach, the few turgor of food, lassitude hypodynamia, has loose bowels, water-damp retention, phlegm and retained fluid, oedema, the cards such as exterior deficiency spontaneous perspiration, have anti-oxidant, delay senility, hypoglycemic, anticoagulation, the effect such as antitumor, the immunologic function of body can be improved, increase quantity of leucocyte, inhibited to staphylococcus aureus, hemolytic streptococcus, diplococcus meningitidis, hay bacillus etc.
Radix pseudostellariae: sweet, the micro-hardship of taste, property is put down, and enters spleen, lung channel, has air making-up and spleen enlivening, the effect that moistening lung is promoted the production of body fluid, the few burnout of food for deficiency-weakness of spleen-QI, deficiency of stomach-Yin, the beneficial temper of energy, nourishing stomach-YIN, for the deficiency syndrome of the lung cough caused by dryness of deficiency of vital energy Tianjin wound and palpitaition egersis, abnormal heat sweat many, energy nourishing generate fluid, controls deficiency of vital energy xeropulmonary cough, the card such as palpitaition egersis, hidrosis of deficiency of both qi and yin.
Saline cistanche: taste is sweet, salty, warm in nature, enters kidney, large intestine channel, has kidney-replenishing, benefiting essence-blood, the effect relaxed bowel, for decline of kidney-YANG, the impotence and premature ejaculation of asthenia of essence and blood, infertile, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, the cards such as intestines of the suffering from a deficiency of the kidney deficiency of blood in dry and postpartum, the constipation that body fluid deficiency after being ill.
Gorgon fruit: taste is sweet, puckery, property is put down.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, tonifying spleen antidiarrheal, the function that clearing damp is only with, cure mainly emission, splenasthenic diarrhea, insufficiency of the spleen gonorrhoea, be with inferior card.
Dioscoreae septemlobae,rhizoma: property is put down, and bitter, returns kidney, stomach warp, has dampness removing and goes turbid, the effect of wind and relieving paralysis of dispelling, for cards such as gonorrhoea gonorrhoea, leukorrhea, damp and hot sore, waist knee numbness pains.
Dragon-boat flower: the flower of Rubiaceae dragon-boat flower plant dragon-boat flower, taste is sweet, light, cool in nature, and have the hemostasis of the loose stasis of blood, menstruation regulating, step-down, clearing liver, invigorates blood circulation, and effect of pain relieving, cures mainly hypertension, irregular menstruation, injured bone, sore.Root, stem: hemoptysis of pulmonary tuberculosis, stomachache, rheumatic arthritis, the cards such as traumatic injury.
Radix Liriopes: sweet, the micro-hardship of taste, cold nature, the thoughts of returning home, lung, stomach warp, have nourishing Yin and promoting production of body fluid, effect that moistening lung clears away heart-fire, and for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as the dry constipation of intestines.
Rabdosia rubescens: bitter, sweet, cold nature, returns lung, stomach, Liver Channel, has clearing heat and detoxicating, effect of promoting blood circulation and stopping pain, cures mainly the cards such as abscess of throat, tonsillitis, cold headache, tracheitis, chronic hepatitis, articular rheumatic pain, snake bite and insect sting.
Dayflower: taste is sweet, light, cold in nature, enter the heart, liver,spleen,kidney, intestine and small intestine warp, have clearing heat and detoxicating, effect of inducing diuresis for removing edema.Cure mainly oedema, beriberi, difficult urination, flu, erysipelas, mumps, icterohepatitis, hot dysentery, malaria, nosebleed epistaxis, hematuria, metrorrhagia, leukorrhea, abscess of throat, the cards such as ulcer furunculosis.
The stem of noble dendrobium: cold nature, taste is sweet, returns stomach, kidney channel, has reinforcing stomach reg fluid, and nourishing Yin and clearing heat effect cures mainly the moon and hinders body fluid deficiency, dry polydipsia, and food is few retches, abnormal heat after being ill, and order is secretly not clear waits card.
Parasitic loranthus: bitter, sweet, property is put down, and enters liver, kidney channel, have the effect of filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic, antiabortive unit, for the soreness of waist pain caused by kidney deficiency and liver, muscles and bones impotence is soft, the foot and knee being feeble, kidney deficiency and liver, essence and blood void is lost, the fetal irritability of liability to be abortion, the cards such as waist abdomen pain.
Radix Glycyrrhizae: taste is sweet, property put down, enter 12 warps, have clearing heat and detoxicating, be in harmonious proportion the property of medicine, the effect of expelling phlegm and arresting coughing, and can invigorating the spleen and in, relieving spasm to stop pain, is mainly used in weakness of the spleen and the stomach abdominal distension and anorexia, weak; Contraction pain in abdomen being alleviated, relax the strong and toxicity of some drugs, alleviate medicine to the toxic and side effect of body or to GI stimulation, tonifying Qi neutralization can be played by adding Radix Glycyrrhizae, be in harmonious proportion the effect of each component.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1 extract
By radix bupleuri 40g, red sage root 25g, oriental wormwood 30g, wilsonii 40g, eclipta 35g, hawthorn 30g, root of kudzu vine 25g, oldenlandia diffusa 20g, stringy stonecrop 25g, radix paeoniae rubrathe 25g, bighead atractylodes rhizome 40g, radix pseudostellariae 45g, saline cistanche 40g, Gorgon fruit 30g, dioscoreae septemlobae,rhizoma 20g, dragon-boat flower 10g, Radix Liriopes 25g, Rabdosia rubescens 30g, Commeline communis 25g, stem of noble dendrobium 30g, Fructus Corni 40g, parasitic loranthus 30g and Radix Glycyrrhizae 25g pulverizes respectively, mix in proportion, obtain mixture, put into multi-function extractor, add distilled water, the volume that every 1kg mixture adds distilled water is 4L, first soak 1h, decoct 3h again, the decoction liquor obtained is filtered, obtain the first filtrate, again distilled water is added in filter residue, the volume adding distilled water in every 1kg filter residue is 3L, decoct 3h again, the decoction liquor obtained is filtered again, obtain filtrate, filtrate is merged, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration remove portion water, obtaining crude drug concentration is the solution of 1g/ml.
Embodiment 2 Chinese medicine composition 2 extract
By radix bupleuri 45g, red sage root 30g, oriental wormwood 35g, wilsonii 45g, eclipta 40g, hawthorn 35g, root of kudzu vine 30g, oldenlandia diffusa 25g, stringy stonecrop 30g, radix paeoniae rubrathe 30g, bighead atractylodes rhizome 45g, radix pseudostellariae 50g, saline cistanche 45g, Gorgon fruit 35g, dioscoreae septemlobae,rhizoma 20g, dragon-boat flower 10g, Radix Liriopes 25g, Rabdosia rubescens 30g, Commeline communis 25g, stem of noble dendrobium 30g, Fructus Corni 40g, parasitic loranthus 30g and Radix Glycyrrhizae 25g pulverizes respectively, mix in proportion, obtain mixture, put into multi-function extractor, add distilled water, the volume that every 1kg mixture adds distilled water is 4L, first soak 1h, decoct 3h again, the decoction liquor obtained is filtered, obtain the first filtrate, again distilled water is added in filter residue, the volume adding distilled water in every 1kg filter residue is 3L, decoct 3h again, the decoction liquor obtained is filtered again, obtain filtrate, filtrate is merged, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration remove portion water, obtaining crude drug concentration is the solution of 1g/ml.
Embodiment 3 Chinese medicine composition 3 extract
By radix bupleuri 40g, red sage root 25g, oriental wormwood 30g, wilsonii 40g, eclipta 35g, hawthorn 30g, root of kudzu vine 25g, oldenlandia diffusa 20g, stringy stonecrop 25g, radix paeoniae rubrathe 25g, bighead atractylodes rhizome 40g, radix pseudostellariae 45g, saline cistanche 40g, Gorgon fruit 30g, dioscoreae septemlobae,rhizoma 15g, dragon-boat flower 5g, Radix Liriopes 20g, Rabdosia rubescens 25g, Commeline communis 20g, stem of noble dendrobium 25g, Fructus Corni 35g, parasitic loranthus 25g and Radix Glycyrrhizae 20g pulverizes respectively, mix in proportion, obtain mixture, put into multi-function extractor, add distilled water, the volume that every 1kg mixture adds distilled water is 4L, first soak 1h, decoct 3h again, the decoction liquor obtained is filtered, obtain the first filtrate, again distilled water is added in filter residue, the volume adding distilled water in every 1kg filter residue is 3L, decoct 3h again, the decoction liquor obtained is filtered again, obtain filtrate, filtrate is merged, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration remove portion water, obtaining crude drug concentration is the solution of 1g/ml.
Embodiment 4 toxicological experiment
Get healthy mice 20, male and female half and half, body weight 20 ± 2.0g, mouse 2-3 in age month.After water 12h is can't help in small white mouse fasting, with 30ml/kg capacity to mice lavage, the amount being converted to crude drug in whole should be 1g/ml × 30ml=30g.After a gastric infusion, with 30ml/kg with dosage fixed point successive administration one week, during administration, small white mouse freely absorbs feed, water, and receptacle temperature remains on 24 ± 4 DEG C, and humidity is 40 ~ 60%.
Observation post administration: the activity, appetite, hair color, breathing etc. of observing administration group and control group small white mouse during administration in 7 days, two groups all consistent, without dead.Stool, urine is normal, and administration group stool is shaping softer, and control group is in comparatively hard particulate.After last administration 24h, dissect two groups of small white mouses, the internal organs such as the gross necropsy small white mouse heart, liver, lung, spleen, kidney, pancreas, two groups all consistent, without any pathological change.
Experimental result: no abnormality seen after mice lavage, all survives.Put to death small white mouse after 7 days, carry out gross necropsy to each main organs, each main organs position, color, size are all without exception.
Conclusion: traditional Chinese medicine composition extract liquid is to be equivalent to the dosage of crude drug in whole 30g/kg to mice lavage, and small white mouse all survives, and illustrates that this Chinese medicine composition is safe.
Embodiment 5 oral liquid
By 1.1kg royal jelly and the mixing of 0.7kg honey, homogeneous with homogenizer, 1.5kg white sugar is dissolved in drinking water, be stirred to white sugar to dissolve completely, filter, filtrate is for subsequent use, by the traditional Chinese medicine composition extract liquid that 0.7kg embodiment 1 obtains, the mixed liquor that the royal jelly obtained above and honey mixing are formed and the refined sugar solution mixing obtained above, obtain mixed solution, add isopyknic drinking water with mixed solution, boil 30 minutes, let cool to room temperature, filter with 0.30 μm of membrane filter, be filled in tubetype glass bottle, gland seal, with 100 DEG C of steam sterilizings 30 minutes, obtain royal jelly liquid.
Embodiment 6 protects liver effect test
Detect sample
Oral liquid prepared by embodiment 5.
Animal used as test
SPF level healthy SD kind male rat 60, body weight (201.0 ± 11.6) g.
Dosage choice and tested material give mode
If 0.540 mL/kg dosage protection group (being equivalent to respectively push away 20 times), separately establishes 1 alcoholic hepatic injury model group (model control group) and 1 negative control group.Often organize 20 animals.Measure 10.8 mL sample solutions, add maize germ oil to 200mL, mix, be made into 5.40% strength solution as high dose group solution, give test solution in per os gavage mode, gavage amount is 1.0mL/100g BW, and model control group and negative control group give isopyknic maize germ oil.
Experimental technique
Tested rat after 5 days at the indoor breeding observing of SPF level zoopery, is divided into 3 groups according to body weight stratified random, i.e. 1 protection group and 2 control groups, often organizes 20.After starting test, protection group rat oral gavage gives the test solution of respective concentration, and model control group and negative control group give maize germ oil, and gavage amount is 1.0mL/100g BW.Every day, gavage 1 time, weighed weekly 1 time, continuous 30 days.When test was to the 30th day, model control group and protection group animal 1 gavage give 50% ethanolic solution 1.2mL/100g BW, manufacture liver injury model; Negative control group is filled with to isopyknic distilled water.Fasting got rat liver after 16 hours, and wherein a part is in order to freezing microtome section, microscopy by following scale after carrying out oil red dyeing: record the score value in 70 visuals field with 40 times of object lens Continuous Observation histotomies, liver cell lactones drips and is dispersed in, and rareness is 0 point; It is 1 point that the liver cell of dripping containing fat is no more than 1/4; It is 2 points that the liver cell of dripping containing fat is no more than 1/2; Dripping liver cell containing fat, to be no more than 3/4 be 3 points; Hepatic tissue is almost dripped instead of 4 points by fat.Another part is made liver tissue homogenate and is measured MDA (MDA), reduced glutathione (GSH) and triglycerides (TG) content respectively.
Statistical procedures
SPSS 13.0 statistical software is adopted to carry out variance analysis statistical disposition.
Result
Tested material, on the impact of alcoholic liver injury in rats hepatic tissue lipid peroxide catabolite MDA (MDA) content, the results are shown in Table 1.
Table 1 is group liver tissues of rats homogenate MDA (MDA) content respectively
| Group | Number of animals (only) | Liver MDA (μm ol/100g hepatic tissue) |
| Protection group | 20 | 20.35±4.0 |
| Negative control group | 20 | 16.91±2.31 |
| Model comparison is rented | 20 | 29.23±3.72 |
Liver damages the MDA content of model control group liver tissues of rats apparently higher than negative control group, and both difference has very significant (P<0.01), illustrates that liver damages model and sets up.The Liver MDA of tested material protection group rat damages model control group lower than liver, and difference has conspicuousness (P<0.01).
Tested material, on the impact of alcoholic liver injury in rats hepatic tissue triglycerides (TG) content, the results are shown in Table 2.
Table 2 Ge Zu rat tissue homogenate (TG) content
| Group | Number of animals (only) | Hepatic tissue TG content (μm ol/100g hepatic tissue) |
| Protection group | 20 | 2.53±0.31 |
| Negative control group | 20 | 2.08±0.22 |
| Model comparison is rented | 20 | 3.39±0.41 |
Liver damages the hepatic tissue TG content of model control group apparently higher than negative control group, and both differences have very significant (P<0.01), illustrates that liver damages model and sets up.The hepatic tissue TG content of tested material protection group rat damages model control group lower than liver, and difference has conspicuousness (P<0.05).
Tested material, on the impact of alcoholic liver injury in rats hepatic tissue reduced glutathione (GSH) content, the results are shown in Table 3.
Table 3 Ge Zu rat tissue homogenate (GSH) content
| Group | Number of animals (only) | Hepatic tissue GSH content (μm ol/100g hepatic tissue) |
| Protection group | 20 | 235.3±19.0 |
| Negative control group | 20 | 263.1±22.3 |
| Model comparison is rented | 20 | 207.9±21.3 |
In the hepatic tissue of liver damage model control group, GSH content is significantly lower than negative control group, and both differences have very significant (P<0.01), shows that liver damages model and sets up.The hepatic tissue GSH content of tested material protection group rat is higher than model control group, and difference has conspicuousness (P<0.05).
Tested material, on the impact of alcoholic liver injury in rats hepatic tissue steatosis, the results are shown in Table 4.
Table 4 is group liver tissues of rats steatosis check result respectively
| Group | Number of animals (only) | Tissue fat sex change is marked |
| Protection group | 20 | 83.3±9.2 |
| Negative control group | 20 | 52.2±17.6 |
| Model comparison is rented | 20 | 143.3±15.2 |
Liver damages the hepatic tissue Steatosis score value of model control group rat higher than negative control group, and both differences have very significant (P<0.01), shows that liver damages model and sets up.Tested material protection group liver tissues of rats Steatosis score value damages model control group lower than liver, and difference has very significant (P<0.01).
MDA is lipid peroxide catabolite; MDA content height indirectly can react body cell and all damage model control group lower than liver by the Liver MDA of tested material protection group rat in this test of degree of free radical attack, shows that this tested material has the effect of LPO in the liver tissues of rats reducing Alcoholic damage.
Reduced glutathione (GSH) can and peroxide and free radical combine, with to the destruction of antioxidant to sulfydryl, containing the protein of sulfydryl with contain sulfydryl enzyme and be not destroyed in Cell protection film, also can resist the infringement of radical pair important organ simultaneously.In this test, the hepatic tissue GSH content of tested material protection group rat is higher than model control group, shows that this tested material has the effect of GSH content in the liver tissues of rats improving alcoholic liver injury.
In hepatic tissue, TG content and hepatic tissue steatosis judge that fat deposits the most direct index in liver cell.In this test, the hepatic tissue TG content of tested material protection group rat damages model control group lower than liver; protection group liver tissues of rats Steatosis score value damages model control group lower than liver, shows that this tested material has triglyceride (TG) content and the effect alleviating hepatic tissue steatosis in the liver tissues of rats reducing Alcoholic damage.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (5)
1. have a royal jelly liquid for liver protection effect, raw material comprises traditional Chinese medicine composition extract liquid 60 weight portion ~ 80 weight portion, royal jelly 100 weight portion ~ 120 weight portion, honey 60 weight portion ~ 80 weight portion and white sugar 140 weight portion ~ 160 weight portion;
It is characterized in that: the bulk drug of described traditional Chinese medicine composition extract liquid comprises radix bupleuri, the red sage root, oriental wormwood, wilsonii, eclipta, hawthorn, the root of kudzu vine, oldenlandia diffusa, stringy stonecrop, the radix paeoniae rubrathe, the bighead atractylodes rhizome, radix pseudostellariae, saline cistanche, Gorgon fruit, dioscoreae septemlobae,rhizoma, dragon-boat flower, Radix Liriopes, Rabdosia rubescens, Commeline communis, the stem of noble dendrobium, Fructus Corni, parasitic loranthus and Radix Glycyrrhizae;
In described traditional Chinese medicine composition extract liquid, the weight portion of each bulk drug is respectively radix bupleuri 35 weight portion ~ 45 weight portion, the red sage root 20 weight portion ~ 30 weight portion, oriental wormwood 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, eclipta 30 weight portion ~ 40 weight portion, hawthorn 25 weight portion ~ 35 weight portion, the root of kudzu vine 20 weight portion ~ 30 weight portion, oldenlandia diffusa 15 weight portion ~ 25 weight portion, stringy stonecrop 20 weight portion ~ 30 weight portion, the radix paeoniae rubrathe 20 weight portion ~ 30 weight portion, the bighead atractylodes rhizome 35 weight portion ~ 45 weight portion, radix pseudostellariae 40 weight portion ~ 50 weight portion, saline cistanche 35 weight portion ~ 45 weight portion, Gorgon fruit 25 weight portion ~ 35 weight portion, dioscoreae septemlobae,rhizoma 15 weight portion ~ 25 weight portion, 5 weight portion ~ 15 weight portions spent by dragon-boat, Radix Liriopes 20 weight portion ~ 30 weight portion, Rabdosia rubescens 25 weight portion ~ 35 weight portion, Commeline communis 20 weight portion ~ 30 weight portion, the stem of noble dendrobium 25 weight portion ~ 35 weight portion, Fructus Corni 35 weight portion ~ 45 weight portion, parasitic loranthus 25 weight portion ~ 35 weight portion and Radix Glycyrrhizae 20 weight portion ~ 30 weight portion,
Described royal jelly liquid is prepared as follows,
The first step, the preparation of traditional Chinese medicine composition extract liquid;
Second step, by royal jelly and honey mixing, homogeneous with homogenizer;
3rd step, is dissolved in white sugar in drinking water, is stirred to white sugar and dissolves completely, and filter, filtrate is for subsequent use;
4th step, the refined sugar solution mixing of the royal jelly that the traditional Chinese medicine composition extract liquid first step obtained, second step obtain and the mixed liquor that honey mixing is formed and the acquisition of the 3rd step, obtain mixed solution, add isopyknic drinking water with mixed solution, boil 20 ~ 40 minutes, let cool to room temperature, filter with 0.25 μm ~ 0.65 μm membrane filter, be filled in tubetype glass bottle, gland seal, with 100 ~ 110 DEG C of steam sterilizings 10 ~ 30 minutes, obtain royal jelly liquid;
Concrete, the preparation method of described traditional Chinese medicine composition extract liquid is specially and above-mentioned raw materials medicine component is pulverized respectively, mix in proportion, obtain mixture, put into multi-function extractor, add distilled water, the volume that every 1kg mixture adds distilled water is 3 ~ 5L, first soak 30min ~ 1h, decoct 2h ~ 3h again, the decoction liquor obtained is filtered, obtain the first filtrate, again distilled water is added in filter residue, the volume adding distilled water in every 1kg filter residue is 2 ~ 4L, decoct 2h ~ 3h again, the decoction liquor obtained is filtered again, obtain filtrate, filtrate is merged, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration remove portion water, obtaining crude drug concentration is the solution of 1g/ml.
2. according to the royal jelly liquid described in claim 1, it is characterized in that: in described traditional Chinese medicine composition extract liquid, the weight portion of each bulk drug is respectively radix bupleuri 40 weight portion ~ 45 weight portion, the red sage root 25 weight portion ~ 30 weight portion, oriental wormwood 30 weight portion ~ 35 weight portion, wilsonii 40 weight portion ~ 45 weight portion, eclipta 35 weight portion ~ 40 weight portion, hawthorn 30 weight portion ~ 35 weight portion, the root of kudzu vine 25 weight portion ~ 30 weight portion, oldenlandia diffusa 20 weight portion ~ 25 weight portion, stringy stonecrop 25 weight portion ~ 30 weight portion, the radix paeoniae rubrathe 25 weight portion ~ 30 weight portion, the bighead atractylodes rhizome 40 weight portion ~ 45 weight portion, radix pseudostellariae 45 weight portion ~ 50 weight portion, saline cistanche 40 weight portion ~ 45 weight portion, Gorgon fruit 30 weight portion ~ 35 weight portion, dioscoreae septemlobae,rhizoma 15 weight portion ~ 20 weight portion, 5 weight portion ~ 10 weight portions spent by dragon-boat, Radix Liriopes 20 weight portion ~ 25 weight portion, Rabdosia rubescens 25 weight portion ~ 30 weight portion, Commeline communis 20 weight portion ~ 25 weight portion, the stem of noble dendrobium 25 weight portion ~ 30 weight portion, Fructus Corni 35 weight portion ~ 40 weight portion, parasitic loranthus 25 weight portion ~ 30 weight portion and Radix Glycyrrhizae 20 weight portion ~ 25 weight portion.
3. royal jelly liquid according to claim 2, it is characterized in that: in described traditional Chinese medicine composition extract liquid, the weight portion of each bulk drug is respectively radix bupleuri 40 weight portion, the red sage root 25 weight portion, oriental wormwood 30 weight portion, wilsonii 40 weight portion, eclipta 35 weight portion, hawthorn 30 weight portion, the root of kudzu vine 25 weight portion, oldenlandia diffusa 20 weight portion, stringy stonecrop 25 weight portion, the radix paeoniae rubrathe 25 weight portion, the bighead atractylodes rhizome 40 weight portion, radix pseudostellariae 45 weight portion, saline cistanche 40 weight portion, Gorgon fruit 30 weight portion, dioscoreae septemlobae,rhizoma 20 weight portion, 10 weight portions spent by dragon-boat, Radix Liriopes 25 weight portion, Rabdosia rubescens 30 weight portion, Commeline communis 25 weight portion, the stem of noble dendrobium 30 weight portion, Fructus Corni 40 weight portion, parasitic loranthus 30 weight portion and Radix Glycyrrhizae 25 weight portion.
4. the preparation method of the royal jelly liquid as described in as arbitrary in claims 1 to 3, is characterized in that:
The first step, the preparation of traditional Chinese medicine composition extract liquid;
Second step, by royal jelly and honey mixing, homogeneous with homogenizer;
3rd step, is dissolved in white sugar in drinking water, is stirred to white sugar and dissolves completely, and filter, filtrate is for subsequent use;
4th step, the refined sugar solution mixing of the royal jelly that the traditional Chinese medicine composition extract liquid first step obtained, second step obtain and the mixed liquor that honey mixing is formed and the acquisition of the 3rd step, obtain mixed solution, add isopyknic drinking water with mixed solution, boil 20 ~ 40 minutes, let cool to room temperature, filter with 0.25 μm ~ 0.65 μm membrane filter, be filled in tubetype glass bottle, gland seal, with 100 ~ 110 DEG C of steam sterilizings 10 ~ 30 minutes, obtain royal jelly liquid.
5. the preparation method of royal jelly liquid according to claim 4, it is characterized in that: the preparation method of described traditional Chinese medicine composition extract liquid is specially and above-mentioned raw materials medicine component is pulverized respectively, mix in proportion, obtain mixture, put into multi-function extractor, add distilled water, the volume that every 1kg mixture adds distilled water is 3 ~ 5L, first soak 30min ~ 1h, decoct 2h ~ 3h again, the decoction liquor obtained is filtered, obtain the first filtrate, again distilled water is added in filter residue, the volume adding distilled water in every 1kg filter residue is 2 ~ 4L, decoct 2h ~ 3h again, the decoction liquor obtained is filtered again, obtain filtrate, filtrate is merged, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration remove portion water, obtaining crude drug concentration is the solution of 1g/ml.
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| CN104305461A (en) * | 2014-10-31 | 2015-01-28 | 庞毅 | Health royal jelly dry powder particle |
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| CN108686199B (en) * | 2017-04-05 | 2023-07-14 | 石药集团中诺药业（泰州）有限公司 | Liver protecting composition |
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| CN1159898A (en) * | 1996-03-14 | 1997-09-24 | 赵吉发 | Health drink and preparing process thereof |
| CN1442092A (en) * | 2002-03-01 | 2003-09-17 | 毛仲朝 | Processing method of functional beverage |
| CN101513488A (en) * | 2009-04-02 | 2009-08-26 | 田家全 | Traditional Chinese medicine compound for treating hepatitis |
| CN101524143A (en) * | 2008-12-15 | 2009-09-09 | 李幸阳 | Oral liquid with main raw materials of honey and royal jelly |
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Patent Citations (4)
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| CN1159898A (en) * | 1996-03-14 | 1997-09-24 | 赵吉发 | Health drink and preparing process thereof |
| CN1442092A (en) * | 2002-03-01 | 2003-09-17 | 毛仲朝 | Processing method of functional beverage |
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