CN103908558A - Traditional Chinese medicine composition for treating acne and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating acne and preparation method and application thereof Download PDFInfo
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- CN103908558A CN103908558A CN201410161798.8A CN201410161798A CN103908558A CN 103908558 A CN103908558 A CN 103908558A CN 201410161798 A CN201410161798 A CN 201410161798A CN 103908558 A CN103908558 A CN 103908558A
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Abstract
The invention provides a traditional Chinese medicine composition for treating acne. According to the technical solution, the active ingredients contained in the traditional Chinese medicine composition are extracted and prepared from the following medicinal raw materials in parts by weight: 10-30 parts of paris polyphylla, 5-15 parts of doellingeria, 10-20 parts of calamus, 5-15 parts of folium artemisiae argyi, 4-8 parts of clove, 5-15 parts of ramie root, 1-3 parts of borneol, 1-3 parts of menthol and solvent (75% alcohol); and tincture is prepared by a corresponding preparation method. The traditional Chinese medicine composition has a function of treating acne.
Description
Technical field
The present invention relates to Chinese medicine preparation technical field, be specifically related to a kind of Chinese medicine composition and method for making and application of Acne treatment.
Background technology
Acne is a kind of chronic inflammatory disease dermatoses of pilosebaceous unit, is mainly apt to occur in teenager, very large to teen-age psychology and social influence, but often can naturally alleviate or fully recover after adolescence.Clinical manifestation is to be apt to occur in the pleomorphism skin lesion such as facial acne, pimple, pustule, tuberosity as feature.The factors such as the generation of acne is main stops up with hypersteatosis, pilosebaceous duct, antibacterial infection and inflammatory reaction are closely related.After adolescing in human body androgen particularly the level of testosterone raise rapidly, promote sebaceous gland to grow and produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes conduit to stop up simultaneously, dyssebacia, and forming horn plug is micropowder thorn.Especially propionibacterium acnes amount reproduction of multiple-microorganism in hair follicle, the lipase that propionibacterium acnes produces decomposes sebum and generates free fatty, chemotactic inflammatory cell and medium simultaneously, final induction exacerbate inflammation reaction.Treatment main method at present: (1) local topical medicine tretinoin (tretinoin emulsifiable paste, adapalene gel, Tazarotene gel), benzoyl peroxide, antibiotics (clindamycin, erythromycin, chloromycetin etc.), Azelaic Acid, sulfur lotion etc.(2) the first-selected Tetracyclines of oral antibiotic (minocycline, doxycycline etc.), is secondly Macrolide (erythromycin), avoids selecting the antibiotic that is usually used in therapy system infection as levofloxacin magnitude.Common 6～12 weeks of antibiotic regimen.(3) oral isotretinoin is for serious acne, and oral isotretinoin is standard treatment, is also the effective method of current Acne treatment.The course for the treatment of is to reach minimum accumulated dose 60mg/kg as target.(4) androgen antagonist is treated as oral contraceptive Compound Cyproterone Acetate Tablets (trade name Diane-35), is applicable in women, severe acne patient, with the too high performance of androgen levels (as hirsutism, seborrhea etc.) or polycystic ovarian syndrome.The female patient that before delayed acne and menstrual phase, acne significantly increases the weight of also can consider to apply oral contraceptive.(5) oral glucocorticoid.The use of these methods often can bring side effect, on the contrary skin is produced to injury, and existing market is badly in need of a kind of medicine for external use of Acne treatment.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of Chinese medicine preparation of Acne treatment.
Another object of the present invention is to provide a kind of Chinese medicine preparation preparation method and application of Acne treatment.
Technical scheme: the object of the invention is to realize by following scheme:
A Chinese medicine composition for Acne treatment, its contained active component is extracted and is prepared from by following raw materials in part by weight medicine proportioning: Rhizoma Paridis 10-30 part, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 5-15 part, Rhizoma Acori Graminei 10-20 part, Folium Artemisiae Argyi 5-15 part, Flos Caryophylli 4-8 part, Radix Boehmeriae 5-15 part, Borneolum Syntheticum 1-3 part, Mentholum 1-3 part.
The Chinese medicine composition of above-mentioned Acne treatment, its contained active component is extracted and is prepared from by following raw materials in part by weight medicine proportioning: 20 parts of Rhizoma Paridis, 10 parts of Rhizoma et Radix Doellingeriae (Herba Doellingeriae), 15 parts of Rhizoma Acori Gramineis, 10 parts of Folium Artemisiae Argyis, 6 parts of Flos Caryophyllis, 10 parts of Radix Boehmeriaes, 2 parts of Borneolum Syntheticums, 2 parts of Mentholums.
The Chinese medicine composition of above-mentioned Acne treatment, described crude drug adds substrate and makes tincture after extracting.
The Chinese medicine composition of above-mentioned Acne treatment, described substrate is 75% ethanol.
The method of the Chinese medicine composition of above-mentioned Acne treatment, preparation process is: get Rhizoma Paridis, Rhizoma et Radix Doellingeriae (Herba Doellingeriae), Rhizoma Acori Graminei, Folium Artemisiae Argyi, Flos Caryophylli, the merging of Radix Boehmeriae medical material, pulverize, make solvent soaking with 75% ethanol, after 1-7 days, get supernatant, add Borneolum Syntheticum and Mentholum is prepared into tincture, fill.
The preparation method of the Chinese medicine composition of above-mentioned Acne treatment, makes solvent soaking more than 7 days with 75% ethanol in step.
The Chinese medicine composition of above-mentioned Acne treatment is in the application of preparing in Retinoids, Retin-A, Renova, Accutane.
Find by clinical and experimental study, Chinese medicine composition of the present invention has good Acne treatment effect.Therefore, the present invention also provides the purposes of aforementioned pharmaceutical compositions, and the Chinese medicine composition of above-mentioned Acne treatment is in the application of preparing in Retinoids, Retin-A, Renova, Accutane.
Beneficial effect: 1, from theory of Chinese medical science, Rhizoma Paridis in we: there is heat-clearing and toxic substances removing, relieving convulsion, pain relieving,, scrofula swollen for pyretic toxicity skin ulcer, venom outward.Rhizoma et Radix Doellingeriae (Herba Doellingeriae): the effect with heat-clearing and toxic substances removing, wind-expelling pain-stopping, activating blood circulation.External curing furuncle and venom.Rhizoma Acori Graminei: have ward off dirty removing toxic substances, outward for carbuncle, skin infection.Folium Artemisiae Argyi: there is clear pathogen removing toxic substances, control skin pruritus, decortication, wind syndrome of head pimples and eczema.Flos Caryophylli: there is sterilizing effect, be applied to furuncle, skin ulcer, furuncle, swollen dermatosis, have functions of detumescence, relieving inflammation, promote Healing.Ramie root: there is heat-clearing and toxic substances removing, external sore and toxic, worm venom.Borneolum Syntheticum: external energy clearing heat for detumescence, antipruritic pain relieving.Mentholum: there is antipruritic, anticorrosion, refrigerant and antiinflammatory action.Solvent 75% ethanol, itself just possesses sterilizing effect, mixes and joins with the strong pure Chinese herbal medicine of All Pure Nature, plays promoting blood circulation to remove obstruction in the collateral, wards off dirty removing toxic substances, drives away ailment said due to cold or exposure miasma, the carbuncle sore furuncle and phyma that disappears, and improves the anti-evil ability of skin.Therefore be unique innovation surgery side of combination medicine, be used for the treatment of acne.2, Formulation of the present invention is reasonable, and compatibility is rigorous.3, the present invention consists of Chinese crude drug, has no side effect, evident in efficacy.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to scope of the present invention.
1,, in conjunction with detailed description of the invention, the present invention is further described as follows:
According to the form below, listed weight proportion takes crude drug required for the present invention, unit: part
| ? | Rhizoma Paridis | Rhizoma et Radix Doellingeriae (Herba Doellingeriae) | Rhizoma Acori Graminei | Folium Artemisiae Argyi | Flos Caryophylli | Radix Boehmeriae | Borneolum Syntheticum | Mentholum |
| 1 | 10 | 15 | 10 | 15 | 4 | 15 | 1 | 3 |
| 2 | 20 | 10 | 15 | 10 | 6 | 10 | 2 | 2 |
| 3 | 30 | 5 | 20 | 5 | 8 | 5 | 3 | 1 |
According to the form below, listed weight proportion takes base starting material required for the present invention, unit: part
In Raw medicine of the present invention, Rhizoma Paridis is the rhizome of liliaceous plant Rhizoma Paridis Paris yunnanensis Franch., Rhizoma et Radix Doellingeriae (Herba Doellingeriae) is Compositae Doellingeria plant Rhizoma et Radix Doellingeriae (Herba Doellingeriae) Doellingeria scaber (Thunb.) Nees [Aster scaber Thunb.], is used as medicine with herb and root.Tap herb summer, adopt root autumn, clean and dry.All the other all select Chinese Pharmacopoeia kind.
2, Preparation Example
More than showing Raw proportioning is example, comprises the following steps:
Embodiment 1: by 1 getting Rhizoma Paridis, Rhizoma et Radix Doellingeriae (Herba Doellingeriae), Rhizoma Acori Graminei, Folium Artemisiae Argyi, Flos Caryophylli, Radix Boehmeriae medical material and merge in above-mentioned table, pulverize, make solvent soaking with 75% ethanol, get supernatant after 1 day, add Borneolum Syntheticum and Mentholum is prepared into tincture, fill.
Embodiment 2: by 1 getting Rhizoma Paridis, Rhizoma et Radix Doellingeriae (Herba Doellingeriae), Rhizoma Acori Graminei, Folium Artemisiae Argyi, Flos Caryophylli, Radix Boehmeriae medical material and merge in above-mentioned table, pulverize, make solvent soaking with 75% ethanol, get supernatant after 3 days, add Borneolum Syntheticum and Mentholum is prepared into tincture, fill.
Embodiment 3: by 1 getting Rhizoma Paridis, Rhizoma et Radix Doellingeriae (Herba Doellingeriae), Rhizoma Acori Graminei, Folium Artemisiae Argyi, Flos Caryophylli, Radix Boehmeriae medical material and merge in above-mentioned table, pulverize, make solvent soaking with 75% ethanol, get supernatant after 7 days, add Borneolum Syntheticum and Mentholum is prepared into tincture, fill.
3. clinical observation and model case: the clinical observation on the therapeutic effect experiment of traditional Chinese medicine composition for treating patients with acne of the present invention
One, all cases of physical data are all from the out-patient between the court's department of dermatologry in January, 2010～2012 year Augusts, 12～40 years old age, year mean age (21 ± 5), the course of disease 2 months～5 years, average course of disease 3 years.Totally 150 examples, adopt random digit method, patient are divided into two groups at random, treatment group 50 examples: wherein male 27 examples, and female's 23 examples, by acne classification level Four improvement staging, point I level acne 15 examples, II level acne 35 examples; Matched group 50 examples: wherein male 20 examples, female's 30 examples, I level acne 28 examples, II level acne 22 examples.Epidemiological Analysis by statistics, above two groups of cases are aspect sex, age, the state of an illness, and difference not statistically significant (P > 0.05), has comparability.
Diagnostic criteria (1) diagnosis reference " clinical dermatology ", " People's Republic of China's Chinese medicine industry standard-TCM Dermatology disease Standardization of diagnosis and curative effect ": there is typical clinical symptoms and sign, skin lesion is mainly being dispersed in property blackhead, inflammatory pimple, pustule, tuberosity, the cyst of involving facial area, is diagnosed as acne person.(2) exclusion standard: 1. with infectious disease person, as: hepatitis, syphilis, acquired immune deficiency syndrome (AIDS) etc.; 2. can not be on demand timing therapist; 3. the person that accepts other treatment in therapeutic process.
Therapeutic Method treatment group is used Chinese medicine raised path between farm fields of the present invention agent, affected part of exterior coating, and 1 is more than 10 times; Matched group only gives the external of clindamycin and metronidazole liniment, every day 2 times.Two groups of homogeneous Zhou Weiyi courses for the treatment of.
Criterion of therapeutical effect is formulated " Chinese medicine (new drug) guideline of clinical investigations " with reference to Ministry of Health of the People's Republic of China: recovery from illness: facial acne erythra all disappears, occur without new breakout, and only stay pigmentation; Effective: acne deflorescence is more than 70%, and inflammation obviously alleviates, occur without new erythra; Effective: acne erythra obviously disappears 20%～70%, there is a small amount of new erythra to occur; Invalid: acne erythra obviously disappears 20%, or still have new erythra to occur.
Therapeutic outcome treatment is added up curative effect after two courses for the treatment of, treatment group 50 examples, and 48 examples of wherein fully recovering, effective 2 examples, total effective rate arrives 98%; Matched group 50 examples, 14 examples of wherein fully recovering, effective 16 examples, effective 12 examples, invalid 8 examples, effective percentage reaches 84%.Two groups of cure rates, total effective rate has significant difference (P < 0.05).
Four. model case
1, Lee XX, female, 17 years old, the acne course of disease was 6 years, and being dispersed in property of face blackhead, inflammatory pimple, be diagnosed as acne, and the tincture that uses the embodiment of the present invention 2 to prepare, uses 10 days continuously, and the disappearance of all diseases is fully recovered, and follows up a case by regular visits to the half a year of not recurrence again.
2, king XX, man 22 years old, the acne course of disease is 1 year, and face has pustule, tuberosity, is diagnosed as acne, and the tincture that uses the embodiment of the present invention 2 to prepare, uses two weeks continuously, and the disappearance of all diseases is fully recovered, and follows up a case by regular visits to the half a year of not recurrence again.
Claims (7)
1. the Chinese medicine composition of an Acne treatment, it is characterized in that, its contained active component is extracted and is prepared from by following raw materials in part by weight medicine proportioning: Rhizoma Paridis 10-30 part, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 5-15 part, Rhizoma Acori Graminei 10-20 part, Folium Artemisiae Argyi 5-15 part, Flos Caryophylli 4-8 part, Radix Boehmeriae 5-15 part, Borneolum Syntheticum 1-3 part, Mentholum 1-3 part, substrate are 75% ethanol.
2. the Chinese medicine composition of Acne treatment as claimed in claim 1, it is characterized in that, its contained active component is extracted and is prepared from by following raw materials in part by weight medicine proportioning: 20 parts of Rhizoma Paridis, 10 parts of Rhizoma et Radix Doellingeriae (Herba Doellingeriae), 15 parts of Rhizoma Acori Gramineis, 10 parts of Folium Artemisiae Argyis, 6 parts of Flos Caryophyllis, 10 parts of Radix Boehmeriaes, 2 parts of Borneolum Syntheticums, 2 parts of Mentholums.
3. the Chinese medicine composition of Acne treatment as claimed in claim 1, is characterized in that, described crude drug adds substrate and makes tincture after extracting.
4. the Chinese medicine composition of Acne treatment as claimed in claim 3, is characterized in that, described substrate is 75% ethanol.
5. prepare the method for the Chinese medicine composition of Acne treatment as claimed in claim 1 for one kind, it is characterized in that, preparation process is: get Rhizoma Paridis, Rhizoma et Radix Doellingeriae (Herba Doellingeriae), Rhizoma Acori Graminei, Folium Artemisiae Argyi, Flos Caryophylli, the merging of Radix Boehmeriae medical material, pulverize, make solvent soaking with 75% ethanol, after 1 ~ 7 day, get supernatant, add Borneolum Syntheticum and Mentholum is prepared into tincture, fill.
6. the preparation method of the Chinese medicine composition of Acne treatment according to claim 5, is characterized in that in step, doing solvent sealing with 75% ethanol soaks more than 7 days.
As described in claim 1 Chinese medicine composition of Acne treatment in the application of preparing in Retinoids, Retin-A, Renova, Accutane.
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| CN104998155A (en) * | 2015-08-12 | 2015-10-28 | 青岛琴诚医药技术有限公司 | Medicinal preparation for treating acne |
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| CN103405698A (en) * | 2013-08-26 | 2013-11-27 | 胡殿宾 | Traditional Chinese medicine liniment for treating acnes and preparation method thereof |
| CN103495086A (en) * | 2013-10-12 | 2014-01-08 | 刘芳 | Externally applied traditional Chinese medicine ointment for treating acne |
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| CN1840070A (en) * | 2006-01-18 | 2006-10-04 | 蒋其锟 | Application of a medicinal composition in preparation of acne-treating medicine |
| CN103405698A (en) * | 2013-08-26 | 2013-11-27 | 胡殿宾 | Traditional Chinese medicine liniment for treating acnes and preparation method thereof |
| CN103495086A (en) * | 2013-10-12 | 2014-01-08 | 刘芳 | Externally applied traditional Chinese medicine ointment for treating acne |
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