CN103908520A - Spleen-invigorating and kidney-nourishing preparation for relieving postoperative radiotherapy reaction of tumor patients and preparation method thereof - Google Patents
Spleen-invigorating and kidney-nourishing preparation for relieving postoperative radiotherapy reaction of tumor patients and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a spleen-invigorating and kidney-nourishing preparation for relieving postoperative radiotherapy reaction of tumor patients. The spleen-invigorating and kidney-nourishing preparation is prepared from the following main raw materials in parts by weight: 8-16 parts of codonopsis pilosula, 9-15 parts of fruit of Chinese wolfberry, 6-12 parts of glossy privet fruit, 6-9 parts of poria with hostwood, 5-11 parts of field thistle, 20-35 parts of root of kudzu vine, 6-15 parts of artemisia anomala, 4-9 parts of bighead atractylodes rhizome, 3-9 parts of semen cuscutae, 8-15 parts of cinnamon, 2-8 parts of fructus psoraleae (processed salt), 2-6 parts of radix clematidis and 3-8 parts of pollen pini. The preparation disclosed by the invention is prepared according to the principle of the traditional Chinese medicines and the physical and mental characteristics of the tumor patients, has a good curative effect on the side effect caused by radiotherapy, and has the effects of invigorating the spleen and nourishing kidneys.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to tonifying speen and tonifying kidney preparation and the preparation method of radiotherapy side effect after a kind of ameliorate tumor operation in patients.
Background technology
Tumor, especially malignant tumor are one of current medical circle the most thorny generally acknowledged persistent ailments, and sickness rate is high, and people's life and health is threatened greatly.At present, radiotherapy is a kind of therapeutic modality that malignant tumor patient extensively adopts, and its principle is: utilize various roentgenization tumor, to suppress and to kill cancerous cell.Radiotherapy can be used separately, also can combined with chemotherapy co-therapy, and as a part for Comprehensive Treatment, radiotherapy can improve the cure rate of tumor.
Radiotherapy belongs to the scope of " sending an expedition against ", tend to occur attacking the positive situation of evil wound, radiotherapy in the treatment tumor is in killing tumor cell, also normal cell and immunity (opposing) cell are together killed, so be the Therapeutic Method of a kind of " destruction of all people good and bad alike ", therefore radiotherapy has more more existing toxicities to spleen, kidney in therapeutic process, has a strong impact on people's spirit and life, very harmful to human body.
The side reaction of radiotherapy shows as:
1. gastricism: a lot of patients can cause a series of symptom accepting radiotherapy after, as appetite declines, dietary amount reduces, nauseating, vomiting, abdominal distention, stomachache, diarrhoea or constipation etc.
2. health is weak: patient is accepting after radiotherapy, to there will be health fatigue and weak, cold perspiration, the drowsiness malaise symptoms that waits.
3. fatigue: malignant tumor patient is at radiation period, because the time is longer, so patient just needs a large amount of some energy that consume human body, the pressure that disease is brought, comes and goes treatment every day and radiation all can cause fatigue to Normocellular impact.
4. immunologic function degression
:radiotherapy can damage patient's immune system, causes patient's immunodeficiency or decline.
5. local response: due to the toleration difference of the each tissue site of health to lonizing radiation, and the type of lonizing radiation, dosage, irradiated area are also different, so the performance of each tissue site is also inconsistent.(1) skin: dry skin shows as skin pruritus, pigmentation and decortication, can produce permanent light brown speckle.Moist cutaneous manifestations is irradiated site eczema, blister, when serious, can cause erosion, ulceration.(2) mucosa reaction: slight: show as oral mucosa redness, erythema, hyperemia, secretions reduces.(3) glandula: glandula is very sensitive to lonizing radiation, be subject to radiation exposure after body of gland destroy, secretion reduce, very easily there is xerostomia, sometimes xerostomia be difficult to eliminate.(4) eyes: the crystal of eyes is very responsive to lonizing radiation, low dose of lonizing radiation can make lenticular opacity, and cataract occurs, and after larger dose is irradiated, can there is ulcer in cornea.(5) skeleton: skeleton, accepting, after a certain amount of radiation exposure, osteoporosis easily occurs, is easily fractured while being subject to external force.Just very responsive to lonizing radiation at the osseous tissue of growth and development stage, low dose of lonizing radiation will make growth be suppressed, and consequently grow and stop, and cause deformity.(6) brain: brain can tolerate median dose to lonizing radiation, heavy dose of lonizing radiation can cause brain atrophy, brain necrosis.Spinal cord has certain toleration to lonizing radiation.Surmounting tolerance dose can penetrating property myelitis, and sensation and the dyskinesia can appear in the lighter, and severe one can hemiplegia, paraplegia etc.
Radiotherapy has certain therapeutic effect to malignant tumor, the slight illness of energy reduction of patient, improve the cure rate of tumor, but due to the toxic and side effects of radiotherapy, especially the inhibition to hemopoietic function, body's immunity, digestive function, make many patients cannot complete its course for the treatment of, thereby had a strong impact on the therapeutic effect of radiotherapy.So development can alleviate the active drug of radiotherapy toxic side effect, tumor remission patient, because of the slight illness that radiotherapy produces, makes malignant tumor patient can better accept radiotherapy, has very important value.
Application publication number is CN 102764371A(application number 201210283513.9) Chinese patent literature a kind of by name " a kind of Chinese medicine compound that alleviates radiotherapy side effect and its preparation method and application " disclosed, this Chinese medicine compound is by Radix Asparagi 10-30 part, Radix Ophiopogonis 10-30 part, Fructus Schisandrae Chinensis 5-10 part, Radix Rehmanniae 10-15 part, Radix Notoginseng 3-5 part, Fructus Ligustri Lucidi 10-30 part, Herba Ecliptae 10-30 part, Fructus Lycii 10-30 part, Fructus Corni 10-30 part, Herba Hedyotidis Diffusae 15-30 part, Poria 10-15 part, Rhizoma Dioscoreae 10-30 part, Fructus Broussonetiae 6-12 part composition.Publication number is CN 101549154A(application number 200910031557.0) Chinese patent literature a kind of by name " a kind of radioprotective and alleviate the nutritional solution of radiotherapy side effect " disclosed, this nutritional solution adds carotene, chitosan, vitamin C, vitamin E etc. by normal saline and makes.
In a word, Chinese medicine is being obtained certain achievement aspect treatment radiotherapy side effect, but also there are some problems: existing oncotherapy preparation can not solve the side reaction of radiotherapy to human body well, to such an extent as to a lot of tumor patients are in heaven in the toxicity of radiotherapy in therapeutic process, therefore need further to be improved perfect.
Summary of the invention
For the deficiencies in the prior art, one of object of the present invention is to provide a kind of tonifying speen and tonifying kidney preparation and preparation method of preparing radiotherapy side effect after simple, taking convenience, portable ameliorate tumor operation in patients.This tonifying speen and tonifying kidney preparation determined curative effect and without any side effects.
Technical scheme of the present invention is:
The tonifying speen and tonifying kidney preparation of radiotherapy side effect after ameliorate tumor operation in patients, takes off the primary raw material of stating weight proportion and is prepared from: Radix Codonopsis 8-16 part, Fructus Lycii 9-15 part, Fructus Ligustri Lucidi 6-12 part, Poria cum Radix Pini 6-9 part, Herba Cirsii 5-11 part, Radix Puerariae 20-35 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Atractylodis Macrocephalae 4-9 part, Semen Cuscutae 3-9 part, Cortex Cinnamomi 8-15 part, Fructus Psoraleae (salt is processed) 2-8 part, Radix Clematidis 2-6 part, Pollen Pini 3-8 part.
The tonifying speen and tonifying kidney preparation of radiotherapy side effect after ameliorate tumor operation in patients, preferred scheme is, takes off the primary raw material of stating weight proportion and is prepared from: Radix Codonopsis 8-16 part, Fructus Lycii 9-15 part, Fructus Ligustri Lucidi 6-12 part, Poria cum Radix Pini 6-9 part, Herba Cirsii 5-11 part, Radix Puerariae 20-35 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Atractylodis Macrocephalae 4-9 part, Semen Cuscutae 3-9 part, Cortex Cinnamomi 8-15 part, Fructus Psoraleae (salt is processed) 2-8 part, Radix Clematidis 2-6 part, Pollen Pini 3-8 part.
The tonifying speen and tonifying kidney preparation of radiotherapy side effect after ameliorate tumor operation in patients, the scheme being more preferably is, takes off the primary raw material of stating weight proportion and is prepared from: Radix Codonopsis 8-16 part, Fructus Lycii 9-15 part, Fructus Ligustri Lucidi 6-12 part, Poria cum Radix Pini 6-9 part, Herba Cirsii 5-11 part, Radix Puerariae 20-35 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Atractylodis Macrocephalae 4-9 part, Semen Cuscutae 3-9 part, Cortex Cinnamomi 8-15 part, Fructus Psoraleae (salt is processed) 2-8 part, Radix Clematidis 2-6 part, Pollen Pini 3-8 part.
The present invention also provides above-mentioned tonifying speen and tonifying kidney preparation has been made to pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.
The preparation method of described powder is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed to 65-125 mesh sieve and (preferably, crossed 80-110 mesh sieve; Be more preferably, cross 95 mesh sieves);
(3) step (1) and (2) gained are mixed.
The preparation method of described water preparation is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) Pollen Pini after step (1) pulverizing is added to step (2) gained medicinal liquid, sterile packaged.
The preparation method of described unguentum is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) pulverizing is added to step (3) gained clear paste, sterile packaged.
The preparation method of described granule is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) qinghuo reagent 0.5-1.2 part (preferably, 0.7-1.0 part; Be more preferably 0.8 part), add the Pollen Pini after step (1) is pulverized, mix, with sucrose 4-7 part (preferably, 5-7 part; Be more preferably 6 parts) and appropriate amount of ethanol, granulation, dry.
The preparation method of described tablet is: by claim 5 gained powder according to 0.4-0.8g/ sheet (preferred, 0.5-0.7g/ sheet; Be more preferably 0.6g/ sheet) measure, be pressed into the lamellar dosage form of circle or other shapes according to the preparation for processing of tablet.
The preparation method of described capsule is: by claim 5 gained medicament powder according to 0.6-1.0g/ grain (preferred, 0.7-0.9g/ grain; Be more preferably 0.8g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Codonopsis: nature and flavor: property is sweet is flat.Gui Jing: return spleen, lung meridian.Effect: strengthening spleen, tonifying kidney, supplementing QI for promoting the production of body fluid.Cure mainly: weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, the spontaneous perspiration of breathing hard, all diseases of deficiency of both QI and blood.
Fructus Lycii: nature and flavor: sweet in the mouth, property is flat.Gui Jing: return liver, kidney channel.Effect: nourishing the liver and kidney, replenishing vital essence to improve eyesight.Cure mainly: asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Fructus Ligustri Lucidi: nature and flavor: sweet in the mouth, hardship, flat.Gui Jing: return liver, kidney channel.Effect: liver and kidney tonifying, clearind deficient heat, strong waist knee joint, improve visual and auditory acuity, black beard and hair.Cure mainly: Light-headedness; Soreness of the waist and knees; Seminal emission; Tinnitus; Early whitening of beard and hair, osteopyrexia and fever.
Poria cum Radix Pini: nature and flavor: sweet in the mouth is light, flat.Gui Jing: GUIXIN, lung meridian.Effect: mind calming, calm the nerves, diuretic.Cure mainly: the palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Herba Cirsii: nature and flavor: sweet in the mouth, micro-hardship, cool.Gui Jing: return liver, spleen, stomach warp.Effect: cooling blood for hemostasis, removing toxic substances and promoting subsidence of swelling.Cure mainly: hematuria, stranguria with blood, hemoptysis, spits blood, and epistaxis, has blood in stool, dysentery, metrorrhagia and metrostaxis, traumatic hemorrhage, swollen ulcer drug.
Radix Puerariae: nature and flavor: sweet in the mouth, pungent is flat.Gui Jing: return spleen, stomach warp.Effect: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure mainly: typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.
Herba Artemisiae Anomalae: nature and flavor: bitter in the mouth, temperature.Gui Jing: GUIXIN, lung meridian.Effect: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Cure mainly: amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.
The Rhizoma Atractylodis Macrocephalae: nature and flavor: bitter in the mouth, sweet, temperature.Gui Jing: return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Cure mainly: deficiency-weakness of spleen-QI weak, lack of appetite abdominal distention, the constipation of having loose bowels, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement.
Semen Cuscutae: nature and flavor: micro-pungent, sweet, flat.Gui Jing: return liver, kidney channel.Effect: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.Cure mainly: the waist knee joint muscles and bones that is applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Cortex Cinnamomi: nature and flavor: acrid in the mouth, sweet, heat.Gui Jing: return kidney, spleen, the heart, Liver Channel.Effect: mend fire supporing yang, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.Cure mainly: insufficiency of kidney-YANG, the aversion to cold and cold limbs of decline of the fire from the gate of life, soreness of the waist and knees, impotence and seminal emission, dysuria or frequency, the dyspnea with rapid and short breath of losing heart, all diseases of edema oliguria; Decline of the fire from the gate of life, fire is Gui Yuan not, floating YANG, refusing yang, and heat in the upper and cold in the lower, flushed complexion cold foot, dizziness and tinnitus, dispute is rotten broken; Spleen-kidney vacuity cold, coldness and pain in the epigastrium, decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain, cold womb is infertile, dysmenorrhea amenorrhea, the stomachache of being retarded by silt puerperal; Carbuncle of yin nature multiple abscess, or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus, or do not hold back after bursting.
Fructus Psoraleae (salt is processed): nature and flavor: acrid in the mouth, hardship, temperature.Gui Jing: return kidney, spleen channel.Effect: reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha.Cure mainly: main insufficiency of kidney-YANG, below element deficiency and cold, chills and pain of the waist and kness, impotence and seminal emission, frequent micturition, the enuresis, failure of the kidney in receiving QI, dyspnea due to deficiency is more than, asthenia of both the spleen and kidney, stool chronic diarrhea, outward for vitiligo, alopecia areata, psoriasis.
Radix Clematidis: nature and flavor: pungent, salty, temperature.Gui Jing: return urinary bladder channel.Effect: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly: gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.
Pollen Pini: nature and flavor: sweet in the mouth, temperature.Gui Jing: return liver, spleen channel.Effect: the QI invigorating of dispeling the wind, removing dampness, hemostasis.Cure mainly: head revolves dizzy, and middle void has a stomach-ache, chronic dysentery, all skin ulcers are wet rotten, wound hemorrhage.
Tonifying speen and tonifying kidney preparation of the present invention, based on traditional Chinese medical herbal treatment radiotherapy side effect principle, is to make on the basis of having studied lot of documents, pharmacology work and clinical trial, has effect of tonifying speen and tonifying kidney, and the side reaction that radiotherapy is caused has good therapeutic effect.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
embodiment 1the tonifying speen and tonifying kidney preparation of radiotherapy side effect after ameliorate tumor operation in patients, takes off the primary raw material of stating weight proportion and is prepared from (getting 10g for every part): 12 parts of Radix Codonopsis, 12 parts of Fructus Lycii, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 8 parts of Herba Cirsiis, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 11 parts of Cortex Cinnamomis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned tonifying speen and tonifying kidney preparation powder is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed to 95 mesh sieves;
(3) step (1) and (2) gained are mixed.
Powder instructions of taking of the present invention: divide 10g/ bag by powder, adopt every day 2-3 time, each one bag, use warm boiled water, 7 days courses for the treatment of.
model case oneyellow XX, the age: 68 years old, sex: female.Symptom: patient is because of superior vena cava syndrome, CT confirms that malignant thymoma, to vertical diaphragm and left the 4th aft rib transfer, performs the operation for 2007 11, postoperatively regularly carries out radiotherapy.There will be that health is tired after the each radiotherapy of patient's readme, nausea and vomiting, inappetence, the thirsty symptom such as hard to bear, take anti-radiotherapy side effect medicine, all without positive effect.Take the tonifying speen and tonifying kidney preparation powder of radiotherapy side effect after the present embodiment gained ameliorate tumor operation in patients, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of.Take 10 days, patient's malaise symptoms is alleviated to some extent, and the food of receiving is cumulative; Take 1 month, patient's malaise symptoms fades away, and spirit, muscle power strengthen; Continue to take 2 months, patient's self-induction is without malaise symptoms.
embodiment 2the tonifying speen and tonifying kidney preparation of radiotherapy side effect after ameliorate tumor operation in patients, takes off the primary raw material of stating weight proportion and is prepared from (getting 20g for every part): 12 parts of Radix Codonopsis, 12 parts of Fructus Lycii, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 8 parts of Herba Cirsiis, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 11 parts of Cortex Cinnamomis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned tonifying speen and tonifying kidney preparation unguentum is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, (water consumption is 3 times of crude drug gross weight) decoction 3 times adds water, 2 hours for the first time, 0.8 hour for the second time, 0.8 hour for the third time, three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) pulverizing is added to step (3) gained clear paste, sterile packaged.
Unguentum instructions of taking of the present invention: unguentum adopts every day 2 times, each 8-12g, takes 7 days courses for the treatment of according to the ratio bath of 1:10.
model case twowoods XX, the age: 40 years old, sex: female.Symptom: patient suffers from shoulder chondrosarcoma for 2006 at hospital surgical, the tumor of swelling again after 2 years increases gradually, regularly radiotherapy is treated, but radiotherapy has caused some uncomfortable reactions: patient immune function declines, resistance weakens, and health is weak, tired, without appetite, skin pruritus, dry, after radiotherapy and with feeling sick, vomit phenomenon.Take the tonifying speen and tonifying kidney preparation unguentum of radiotherapy side effect after the present embodiment gained ameliorate tumor operation in patients, adopt every day 2 times, each 12g, takes 7 days courses for the treatment of according to the ratio bath of 1:10.Take 14 days, patient's malaise symptoms alleviates, and appetite strengthens; Take 2 months, the dry pruritus of patient skin alleviates, and resistance strengthens; Continue to take the recovery from illness of patient's self-induction 2 months.
embodiment 3the tonifying speen and tonifying kidney preparation of radiotherapy side effect after ameliorate tumor operation in patients, takes off the primary raw material of stating weight proportion and is prepared from (every part of 30g): 12 parts of Radix Codonopsis, 12 parts of Fructus Lycii, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 8 parts of Herba Cirsiis, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 11 parts of Cortex Cinnamomis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned tonifying speen and tonifying kidney preparation granules agent is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, (water consumption is 3 times of crude drug gross weight) decoction 3 times adds water, 2 hours for the first time, 0.8 hour for the second time, 0.8 hour for the third time, three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) 0.8 part of qinghuo reagent, adds the Pollen Pini after step (1) is pulverized, mixes, and with 6 parts of sucrose and appropriate amount of ethanol, granulation, dry.
Granule instructions of taking of the present invention: divide 10g/ bag by granule, every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.
model case threepoplar XX, the age: 72 years old, sex: man.Symptom: patient does stomach resecting operation in March, 2008, does afterwards radiotherapy always and treats, and there will be following malaise symptoms after the each radiotherapy of patient's readme: lassitude, and without appetite, malaise, skin abnormality is dry, drowsiness etc.Take the tonifying speen and tonifying kidney preparation granules agent of radiotherapy side effect after the present embodiment gained ameliorate tumor operation in patients, adopt every day 3 times, each 1 one bags, with warm boiled water, 7 days courses for the treatment of.Take 21 days, patient's appetite strengthens, and malaise symptoms improves gradually; Take 2 months, patient's muscle power obviously strengthens, and the mental status is clearly better; Continue to take 1 month, malaise symptoms disappears.
embodiment 4the tonifying speen and tonifying kidney preparation of radiotherapy side effect after ameliorate tumor operation in patients, takes off the primary raw material of stating weight proportion and is prepared from (every part of 40g): 12 parts of Radix Codonopsis, 12 parts of Fructus Lycii, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 8 parts of Herba Cirsiis, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 11 parts of Cortex Cinnamomis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned tonifying speen and tonifying kidney preparation tablet is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed to 95 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain to powder;
(4) step (3) gained powder is measured according to 0.6g/ sheet, be pressed into the lamellar dosage form of circle or other shapes according to the preparation for processing of tablet.
Tablets method of the present invention: tablet adopts every day 3 times, each 4-6 sheet, with warm boiled water, 7 days courses for the treatment of.
model case fourking XX, the age: 50 years old, sex: man.In November, 2006 is because of right root of the tongue portion scale cancer, and bottom right Cervical Lymph Node Metastasis, through hospital's radiotherapy, occurs the malaise symptoms such as cavity curing ulcer erosion, dry mouth and tougue, dysphagia, lassitude, health be tired.Take the tonifying speen and tonifying kidney preparation tablet of radiotherapy side effect after the present embodiment gained ameliorate tumor operation in patients, inferior to every day 3 times, each 5, with warm boiled water, 7 days courses for the treatment of.Take 14 days, dry mouth and tougue alleviates, and oral ulcer is rotten to the corn to take a turn for the better; Take 1 month, patient's appetite strengthens, and the mental status is improved, and malaise symptoms fades away; Continue to take 1 month, patient's malaise symptoms disappears completely.
embodiment 5the tonifying speen and tonifying kidney preparation of radiotherapy side effect after ameliorate tumor operation in patients, takes off the primary raw material of stating weight proportion and is prepared from (every part of 50g): 12 parts of Radix Codonopsis, 12 parts of Fructus Lycii, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 8 parts of Herba Cirsiis, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 11 parts of Cortex Cinnamomis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned tonifying speen and tonifying kidney preparation capsule is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed to 95 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain to powder;
(4) step (3) gained powder is measured according to 0.8g/ grain, be processed into capsule shape dosage form according to the preparation for processing of capsule.
Capsule instructions of taking of the present invention: capsule adopts every day 3 times, each 5-8 grain, with warm boiled water, 7 days courses for the treatment of.
model case fivexiao XX, the age: 63 years old, sex: female.Find that at examination in hospital malignant tumor appears in liver in June, 2008, because of tumor larger, should not perform the operation, therefore do radiotherapy and alleviate slight illness, but radiotherapy causes some side reactions: acra is insensitive, nausea and vomiting, diarrhoea, health are weak, skin pruritus etc.Take the tonifying speen and tonifying kidney preparation capsule of radiotherapy side effect after the present embodiment gained ameliorate tumor operation in patients, adopt every day 3 times, each 6, with warm boiled water, 7 days courses for the treatment of.Take 20 days, patients ' vomiting alleviates, and diarrhoea also alleviates; Take 2 months, patient's malaise symptoms fades away, and acra sensation is sensitive before; Continue to take 2 months, patient's symptom that feels uneasy disappears completely.
embodiment 6the tonifying speen and tonifying kidney preparation of radiotherapy side effect after ameliorate tumor operation in patients, takes off the primary raw material of stating weight proportion and is prepared from (every part of 60g): 12 parts of Radix Codonopsis, 12 parts of Fructus Lycii, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 8 parts of Herba Cirsiis, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 11 parts of Cortex Cinnamomis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned tonifying speen and tonifying kidney preparation water preparation is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, (water consumption is 3 times of crude drug gross weight) decoction 3 times adds water, 2 hours for the first time, 0.8 hour for the second time, 0.8 hour for the third time, three gained filtrates are merged, leave standstill, filter;
(3) Pollen Pini after step (1) pulverizing is added to step (2) gained medicinal liquid, sterile packaged.
Water preparation instructions of taking of the present invention: water preparation adopts every day 2 times (warm), each 350-550ml, 7 days courses for the treatment of.
test example 1the clinical practice of the tonifying speen and tonifying kidney preparation water preparation of radiotherapy side effect after embodiment 6 gained ameliorate tumor operation in patients: in October, 2007-2011 year April, screen 100 routine patients in 5 hospitals, wherein women's 48 examples, male's 52 examples.Before test 2 weeks, this crowd is carried out to Continuous Observation, record symptom and variation, be divided at random two groups, experimental group and matched group, experimental group is taken embodiment 6 products obtained therefroms, and matched group is taken other medicine conventional medicines such as () safe peace oral liquid, selenium Wei Kang.Using method is: take every day twice (warm), each 350m1-550m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of.Curative effect situation criterion: cure: take a course for the treatment of of this product, malaise symptoms disappears, energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 6 products obtained therefrom therapeutic effect checkings
| Experimental group | Matched group | |
| Number of cases | 50 | 50 |
| Male's number of cases | 26 | 26 |
| Women's number of cases | 24 | 24 |
| Clinical cure number of cases | 36 | 11 |
| Effectively number of cases | 13 | 26 |
| Invalid number of cases | 1 | 13 |
| Total effective rate | 98% | 74% |
Therapeutic effect: cure 36 examples (72%), effective 13 examples (26%), invalid 1 example (2%), total effective rate 98%.Successful is better than matched group.
During taking, self-induction symptom and physical change of spirit thereof are as shown in table 2.
Table 2:
As shown in Table 2: take 15 days, more than 53% patients ' vomiting alleviates, malaise symptoms takes a turn for the better to some extent; Take 30 days, more than 72% patient feels to take a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 45 days, more than 95% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, the recovery from illness of some patients were self-induction.In experimental group, take more than 45 days, effective percentage can reach 95%, and matched group is only 76%.
Finally it should be noted that, embodiment is the specific embodiment of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the tonifying speen and tonifying kidney preparation of radiotherapy side effect after ameliorate tumor operation in patients, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Radix Codonopsis 8-16 part, Fructus Lycii 9-15 part, Fructus Ligustri Lucidi 6-12 part, Poria cum Radix Pini 6-9 part, Herba Cirsii 5-11 part, Radix Puerariae 20-35 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Atractylodis Macrocephalae 4-9 part, Semen Cuscutae 3-9 part, Cortex Cinnamomi 8-15 part, Fructus Psoraleae (salt is processed) 2-8 part, Radix Clematidis 2-6 part, Pollen Pini 3-8 part.
2. tonifying speen and tonifying kidney preparation according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Radix Codonopsis 10-14 part, Fructus Lycii 11-13 part, Fructus Ligustri Lucidi 8-10 part, Poria cum Radix Pini 6-8 part, Herba Cirsii 7-9 part, Radix Puerariae 25-30 part, Herba Artemisiae Anomalae 9-12 part, Rhizoma Atractylodis Macrocephalae 5-8 part, Semen Cuscutae 5-7 part, Cortex Cinnamomi 10-13 part, Fructus Psoraleae (salt is processed) 4-6 part, Radix Clematidis 3-5 part, Pollen Pini 5-7 part.
3. tonifying speen and tonifying kidney preparation according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: 12 parts of Radix Codonopsis, 12 parts of Fructus Lycii, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 8 parts of Herba Cirsiis, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 11 parts of Cortex Cinnamomis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
4. according to the arbitrary described tonifying speen and tonifying kidney preparation of claim 1-3, it is characterized in that, said preparation is made to pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.
5. tonifying speen and tonifying kidney preparation according to claim 4, is characterized in that, the preparation method of described powder is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed to 65-125 mesh sieve and (preferably, crossed 80-110 mesh sieve; Be more preferably, cross 95 mesh sieves);
(3) step (1) and (2) gained are mixed.
6. tonifying speen and tonifying kidney preparation according to claim 4, is characterized in that, the preparation method of described water preparation is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) Pollen Pini after step (1) pulverizing is added to step (2) gained medicinal liquid, sterile packaged.
7. tonifying speen and tonifying kidney preparation according to claim 4, is characterized in that, the preparation method of described unguentum is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) pulverizing is added to step (3) gained clear paste, sterile packaged.
8. tonifying speen and tonifying kidney preparation according to claim 4, is characterized in that, the preparation method of described granule is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Fructus Lycii, Fructus Ligustri Lucidi, Poria cum Radix Pini, Herba Cirsii, Radix Puerariae, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Cortex Cinnamomi, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) qinghuo reagent 0.5-1.2 part (preferably, 0.7-1.0 part; Be more preferably 0.8 part), add the Pollen Pini after step (1) is pulverized, mix, with sucrose 4-7 part (preferably, 5-7 part; Be more preferably 6 parts) and appropriate amount of ethanol, granulation, dry.
9. tonifying speen and tonifying kidney preparation according to claim 4, is characterized in that, the preparation method of described tablet is: by claim 5 gained powder according to 0.4-0.8g/ sheet (preferred, 0.5-0.7g/ sheet; Be more preferably 0.6g/ sheet) measure, be pressed into the lamellar dosage form of circle or other shapes according to the preparation for processing of tablet.
10. tonifying speen and tonifying kidney preparation according to claim 4, is characterized in that, the preparation method of described capsule is: by claim 5 gained powder according to 0.6-1.0g/ grain (preferred, 0.7-0.9g/ grain; Be more preferably 0.8g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104605387A (en) * | 2015-02-10 | 2015-05-13 | 王亚利 | Nutritional herbal cuisine capable of relieving postoperation radiotherapy response of cancer patient |
| CN104757570A (en) * | 2015-04-27 | 2015-07-08 | 刘晓红 | Herbal cuisine releasing hepatorenal function damage caused by radiation treatment and preparation method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184659A (en) * | 1997-11-14 | 1998-06-17 | 张锡昆 | Traditional Chinese medicine for tonifying kidney and strengthening spleen and stomach |
| CN102363009A (en) * | 2011-10-21 | 2012-02-29 | 北京同仁堂天然药物有限公司 | Traditional Chinese medicine composition with yin nourishing, yang assisting, vital essence reinforcing, and primordial qi strengthening efficacies |
| CN102764371A (en) * | 2012-08-09 | 2012-11-07 | 南京中医药大学 | Traditional Chinese medicine compound prescription for relieving radiotherapy side reactions and preparation method and application thereof |
| CN103536638A (en) * | 2013-10-22 | 2014-01-29 | 第三军医大学第二附属医院 | Medicament for treating gastrointestinal dysfunction and preparation method thereof |
-
2014
- 2014-04-12 CN CN201410144863.6A patent/CN103908520A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184659A (en) * | 1997-11-14 | 1998-06-17 | 张锡昆 | Traditional Chinese medicine for tonifying kidney and strengthening spleen and stomach |
| CN102363009A (en) * | 2011-10-21 | 2012-02-29 | 北京同仁堂天然药物有限公司 | Traditional Chinese medicine composition with yin nourishing, yang assisting, vital essence reinforcing, and primordial qi strengthening efficacies |
| CN102764371A (en) * | 2012-08-09 | 2012-11-07 | 南京中医药大学 | Traditional Chinese medicine compound prescription for relieving radiotherapy side reactions and preparation method and application thereof |
| CN103536638A (en) * | 2013-10-22 | 2014-01-29 | 第三军医大学第二附属医院 | Medicament for treating gastrointestinal dysfunction and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 杨宝印编著: "《癌症的中药治疗》", 29 February 1992, 河北科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104605387A (en) * | 2015-02-10 | 2015-05-13 | 王亚利 | Nutritional herbal cuisine capable of relieving postoperation radiotherapy response of cancer patient |
| CN104757570A (en) * | 2015-04-27 | 2015-07-08 | 刘晓红 | Herbal cuisine releasing hepatorenal function damage caused by radiation treatment and preparation method |
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