CN103843764B - A kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof - Google Patents
A kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof Download PDFInfo
- Publication number
- CN103843764B CN103843764B CN201410122384.4A CN201410122384A CN103843764B CN 103843764 B CN103843764 B CN 103843764B CN 201410122384 A CN201410122384 A CN 201410122384A CN 103843764 B CN103843764 B CN 103843764B
- Authority
- CN
- China
- Prior art keywords
- disinfectant solution
- glutaraldehyde
- preparation
- strengthening modified
- modified glutaraldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical class O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 239000000645 desinfectant Substances 0.000 title claims abstract description 36
- 238000005728 strengthening Methods 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000003756 stirring Methods 0.000 claims abstract description 13
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims abstract description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 12
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 12
- 239000008103 glucose Substances 0.000 claims abstract description 12
- -1 polyoxyethylene Polymers 0.000 claims abstract description 12
- 239000008213 purified water Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 abstract description 30
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 230000002159 abnormal effect Effects 0.000 abstract description 3
- 230000001580 bacterial effect Effects 0.000 abstract description 3
- 230000035943 smell Effects 0.000 abstract description 3
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 231100000053 low toxicity Toxicity 0.000 abstract description 2
- 244000005700 microbiome Species 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 11
- 229960000587 glutaral Drugs 0.000 description 11
- 241000700605 Viruses Species 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 5
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 5
- 244000063299 Bacillus subtilis Species 0.000 description 4
- 235000014469 Bacillus subtilis Nutrition 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 241000726221 Gemma Species 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 238000012952 Resampling Methods 0.000 description 2
- 230000000507 anthelmentic effect Effects 0.000 description 2
- 206010064097 avian influenza Diseases 0.000 description 2
- 210000001508 eye Anatomy 0.000 description 2
- 230000000415 inactivating effect Effects 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- BHTJEPVNHUUIPV-UHFFFAOYSA-N pentanedial;hydrate Chemical compound O.O=CCCCC=O BHTJEPVNHUUIPV-UHFFFAOYSA-N 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010035745 Pneumonitis chemical Diseases 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 201000009408 aspiration pneumonitis Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000017 mucous membrane irritation Toxicity 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof, relates to disinfectant.The raw material composition of described strengthening modified glutaraldehyde disinfectant solution and content by mass percentage thereof are glutaraldehyde 18%～22%, glucose 5%～10%, polyoxyethylene aliphatic alcohol ether 5%～10%, purified water 58%～72%.Glutaraldehyde, glucose, purified water are added heated and stirred in retort, then polyoxyethylene aliphatic alcohol ether adds continuation stirring in retort, after being cooled to room temperature, i.e. obtains strengthening modified glutaraldehyde disinfectant solution.Product is aqueous solution, good stability, and abnormal smells from the patient is thin；Major part microorganism can be killed；Aerobic and the sprouting of anaerobic spore can be suppressed under very low concentrations；Use pH wide ranges, can higher temperature resistant；Bacterial propagule can be killed in 2min；Sterilizing in Organic substance and crack can be penetrated；Ambient temperatare puts 540d, and sterilizing usefulness does not subtracts；Noresidue, zest is little, and corrosivity is low, safety and low toxicity.
Description
Technical field
The present invention relates to a kind of disinfectant, especially relate to a kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof.
Background technology
Glutaraldehyde not only to the well killing action such as bacterial propagule, spore, tubercule bacillus, fungus and virus, also has relatively
Strong anthelminthic effect, is the best substitute of formaldehyde (formalin).Glutaral disinfectant solution stability in the market is relatively
Difference, irritant abnormal smells from the patient, eyes, skin and mucosa there are is strong impulse effect, suction can cause larynx, bronchus
Inflammation, chemical pneumonitis, pulmonary edema etc., also can cause allergic reaction.
Chinese patent CN94102774.0 provides a kind of stable glutaraldehyde water solution, and formula is: glutaraldehyde water solution, non-
Ionic detergent, sodium acetate and be enough to the pH adjusting agent of the q.s making solution ph be 6.9～8.5.
Summary of the invention
It is an object of the invention to provide and have sterilization effect preferably, action time is short, and action effect is stable, zest gas
Taste is little, less to eyes, skin and mucous membrane irritation effect, has again a kind of strengthening modified glutaraldehyde sterilization of stronger anthelminthic effect
Liquid and preparation method thereof.
The raw material composition of described strengthening modified glutaraldehyde disinfectant solution and content by mass percentage thereof be glutaraldehyde 18%～22%,
Glucose 5%～10%, polyoxyethylene aliphatic alcohol ether 5%～10%, purified water 58%～72%.
Specifically comprising the following steps that of the preparation method of described strengthening modified glutaraldehyde disinfectant solution
Glutaraldehyde, glucose, purified water are added heated and stirred in retort, then polyoxyethylene aliphatic alcohol ether is added retort
Middle continuation stirs, and after being cooled to room temperature, must strengthen modified glutaraldehyde disinfectant solution.
The condition of described heated and stirred can be to stir 180～300min with 50r/min speed at 40～60 DEG C；Described continuation stirs
The time mixed can be 45～90min.
The present invention prepares the strengthening modified glutaraldehyde disinfectant solution of gained and can transport with transfer cask, and resampling detects, and detection is passed through
After, then transfer cask is delivered to packing shop pack according to the requirement of client.Described transfer cask is preferably 100L transfer cask；
Described resampling detects, and after preferably transfer cask places at least 12h, just sampling detects.
Comparing with like product, the present invention has an advantage highlighted below:
1) product is aqueous solution, good stability, and abnormal smells from the patient is thin.
2) more efficient: broad-spectrum sterilization, most microorganism can be killed；Aerobic and anaerobic can be suppressed under very low concentrations
The sprouting of spore；Use pH wide ranges, can higher temperature resistant.
3) more rapid: generally, bacterial propagule can be killed in 2min；There is extremely strong penetration power, can there is penetrated with
Sterilizing in machine thing and crack.
4) more longlasting: ambient temperatare puts 540d, sterilizing usefulness does not subtracts.
5) safer: noresidue, zest is little, and corrosivity is low, safety and low toxicity.
Detailed description of the invention
The present invention is further illustrated for following example.
Embodiment 1
The raw material composition of described strengthening modified glutaraldehyde disinfectant solution and content by mass percentage thereof are glutaraldehyde 18%, glucose
6%, polyoxyethylene aliphatic alcohol ether 6%, purified water 70%.
The preparation method of strengthening modified glutaraldehyde disinfectant solution of the present invention comprises the following steps:
1) glutaraldehyde, purified water, glucose are added retort, be heated to 40～60 DEG C, at this temperature with 50r/min speed
Degree stirring, mixing time 180～300min.
2) polyoxyethylene aliphatic alcohol ether is added retort, continue stirring 45～90min.
3) it is cooled to room temperature, obtains product.
4) step 3) products obtained therefrom is loaded 100L transfer cask, sample after placing 12h and detect, then transfer cask is delivered to
Packing shop is packed according to the requirement of client.
Use the scene (wall to H9N2 bird flu virus (AIV) of the strengthening modified glutaraldehyde disinfectant solution prepared by embodiment 1
Wall, utensil) Disinfection Effect: found by on-site disinfection test, 1: 200 strengthening modified glutaraldehyde disinfectant solution effect 30min or
AIV H9N2 can be killed by 1: 500 mass action 60min completely.In view of disinfectant when reality is applied can by many because of
The impact of element, therefore need to adjust disinfectant concentration and action time in time, to reach when reality is applied according to practical situation
Desired sanitisation effect.Strengthening modified glutaraldehyde disinfectant solution sees table 1 to the result for spot disinfection of H9N2 bird flu virus (AIV).
Table 1
Product physicochemical property:
Character: this product is colourless to weak yellow liquid；
Relative density: 1.030～1.040；
PH value: 2.9.
Embodiment 2
The raw material composition of described strengthening modified glutaraldehyde disinfectant solution and content by mass percentage thereof are glutaraldehyde 20%, glucose
7%, polyoxyethylene aliphatic alcohol ether 7%, purified water 66%.
The preparation method of described strengthening modified glutaraldehyde disinfectant solution comprises the following steps:
1) glutaraldehyde, purified water, glucose are added retort, be heated to 40～60 DEG C, at this temperature with 50r/min speed
Degree stirring, mixing time 180～300min.
2) polyoxyethylene aliphatic alcohol ether is added retort, continue stirring 45～90min.
3) it is cooled to room temperature, obtains product.
4) step 3) products obtained therefrom being loaded 100L transfer cask, after placing 12h, just sampling detects, then is sent by transfer cask
Pack to packing shop according to the requirement of client.
The use strengthening modified glutaraldehyde disinfectant solution prepared by embodiment 2 inactivating efficacy to Pseudorabies virus (PRV):
More than containing 3000mg/L strengthening modified glutaraldehyde disinfectant solution and Pseudorabies virus suspension immixture 30min, respectively test
Group is all not detected by survival virus.Test shows, 3000mg/L strengthening modified glutaraldehyde disinfectant solution is to Pseudorabies virus in suspension
Effect 30min, can reach complete inactivation.Strengthening modified glutaraldehyde disinfectant solution sees table 2 to the inactivating efficacy of Pseudorabies virus.
Table 2
| Action time (min) | Inactivation of virus titre logarithm value |
| 30 | ≥6.50 |
| 60 | ≥6.50 |
| 120 | ≥6.50 |
| 240 | ≥6.50 |
Note: the logarithm value of positive control virus titre (TCID50/0.1ml) is 6.50
Embodiment 3
The raw material composition of described strengthening modified glutaraldehyde disinfectant solution and content by mass percentage thereof are glutaraldehyde 22%, glucose
8%, polyoxyethylene aliphatic alcohol ether 8%, purified water 62%.
The preparation method of described strengthening modified glutaraldehyde disinfectant solution comprises the following steps:
1) glutaraldehyde, purified water, glucose are added retort, be heated to 40～60 DEG C, at this temperature with 50r/min speed
Degree stirring, mixing time 180～300min.
2) polyoxyethylene aliphatic alcohol ether is added retort, continue stirring 45～90min.
3) it is cooled to room temperature, obtains product.
4) step 3) products obtained therefrom being loaded 100L transfer cask, after placing 12h, just sampling detects, then is sent by transfer cask
Pack to packing shop according to the requirement of client.
Use the strengthening modified glutaraldehyde disinfectant solution prepared by embodiment 3 that bacillus subtilis black variety gemma on carrier is killed effect
Really:
Test shows, strengthening modified glutaraldehyde disinfectant solution (experimental group) with concentration as 20g/L is to bacillus subtilis black on carrier
Mutation spore effect 60min, averagely killing logarithm value is 5.09.Under same concentrations, common glutaral disinfectant solution (matched group) is right
Bacillus subtilis black variety gemma effect 60min on carrier, averagely killing logarithm value is 3.98.
Table 3
Strengthening modified glutaraldehyde disinfectant solution sees table 3 to the killing effect of bacillus subtilis black variety gemma on carrier.
Claims (3)
1. the preparation method strengthening modified glutaraldehyde disinfectant solution, it is characterised in that its raw material composition and content by mass percentage thereof be glutaraldehyde 18%～22%, glucose 5%～10%, polyoxyethylene aliphatic alcohol ether 5%～
10%, purified water 58%～72%, glutaraldehyde, glucose, purified water are added heated and stirred in retort by specifically comprising the following steps that of its preparation method, again polyoxyethylene aliphatic alcohol ether is added and retort continues stirring, after being cooled to room temperature, modified glutaraldehyde disinfectant solution must be strengthened.
2. a kind of preparation method strengthening modified glutaraldehyde disinfectant solution as described in claim 1, it is characterised in that the condition of described heated and stirred is to stir with 50r/min speed at 40～60 DEG C
180～300min.
A kind of preparation method strengthening modified glutaraldehyde disinfectant solution the most as claimed in claim 1, it is characterised in that the time of described continuation stirring is 45～90min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410122384.4A CN103843764B (en) | 2014-03-28 | 2014-03-28 | A kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410122384.4A CN103843764B (en) | 2014-03-28 | 2014-03-28 | A kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103843764A CN103843764A (en) | 2014-06-11 |
| CN103843764B true CN103843764B (en) | 2016-08-17 |
Family
ID=50852222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410122384.4A Active CN103843764B (en) | 2014-03-28 | 2014-03-28 | A kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103843764B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112931502A (en) * | 2019-12-11 | 2021-06-11 | 山东菏泽三仪生物工程有限公司 | Compound glutaraldehyde reinforced disinfectant and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100135A (en) * | 1993-01-29 | 1995-03-15 | 托尼·马丁销售和批发公司 | A glutaraldehyde composition |
| CN103118538A (en) * | 2010-06-25 | 2013-05-22 | Gx实验室控股有限公司 | Disinfecting and sterilising solutions |
-
2014
- 2014-03-28 CN CN201410122384.4A patent/CN103843764B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100135A (en) * | 1993-01-29 | 1995-03-15 | 托尼·马丁销售和批发公司 | A glutaraldehyde composition |
| CN103118538A (en) * | 2010-06-25 | 2013-05-22 | Gx实验室控股有限公司 | Disinfecting and sterilising solutions |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103843764A (en) | 2014-06-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Smilanick et al. | Control of citrus postharvest green mold and sour rot by potassium sorbate combined with heat and fungicides | |
| McKeen | Introduction to food irradiation and medical sterilization | |
| Hao et al. | Roles of hydroxyl radicals in electrolyzed oxidizing water (EOW) for the inactivation of Escherichia coli | |
| CN108605933B (en) | Fatty acid compound | |
| HK1252945A1 (en) | Aqueous hypochlorous acid solution | |
| Tang et al. | Disinfection effect and its mechanism of electrolyzed oxidizing water on spores of Bacillus subtilis var. niger | |
| Xiong et al. | The antifungal mechanism of electrolyzed oxidizing water against Aspergillus flavus | |
| Stefanello et al. | Comparison of electrolized water and multiple chemical sanitizer action against heat-resistant molds (HRM) | |
| Siddique et al. | Sonolytic-ozonation technology for sanitizing microbial contaminants and pesticide residues from spinach (Spinacia oleracea L.) leaves, at household level | |
| CN112741087A (en) | Cold chain food disinfectant and preparation method thereof | |
| Phothisuwan et al. | Enhancement of antibacterial activity of essential oil vapor released from a paper egg tray in combination with UV‐C radiation against pathogenic bacteria on chicken eggs | |
| CN114223669B (en) | Chlorine dioxide unitary disinfectant and preparation method and application thereof | |
| Frisón et al. | Effect of different sanitizers against Zygosaccharomyces rouxii | |
| CN103843764B (en) | A kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof | |
| CN108902145A (en) | A kind of bactericidal composition and its preparation and application | |
| CN113170801A (en) | Disinfectant and preparation method and application thereof | |
| CN114342925A (en) | Disinfecting composition and preparation method and application thereof | |
| CN106942258A (en) | Cationic surfactant composite disinfectant for animals and preparation method and application | |
| JP7668490B2 (en) | Disinfectant | |
| CN113940358B (en) | Efficient alcohol-free guanidine compound disinfectant and preparation method thereof | |
| WO2022126976A1 (en) | Special disinfectant for meat, and preparation method therefor | |
| JP2015187084A (en) | Bactericidal composition | |
| KR101253428B1 (en) | Manufacturing method of reconstituted infant formula using nature-derived antimicrobial compounds | |
| CN113317327A (en) | Bactericidal virucidal enzyme preparation composition and application thereof | |
| WO2021113384A1 (en) | Systems and methods for disinfecting meat products |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |