CN103800562A - Preparation with functions of breath refreshing, spirit improving and fatigue relieving - Google Patents
Preparation with functions of breath refreshing, spirit improving and fatigue relieving Download PDFInfo
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- CN103800562A CN103800562A CN201210436913.9A CN201210436913A CN103800562A CN 103800562 A CN103800562 A CN 103800562A CN 201210436913 A CN201210436913 A CN 201210436913A CN 103800562 A CN103800562 A CN 103800562A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims abstract description 28
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 24
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229960001948 caffeine Drugs 0.000 claims abstract description 14
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims abstract description 14
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 14
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 14
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960003080 taurine Drugs 0.000 claims abstract description 12
- 241000208340 Araliaceae Species 0.000 claims abstract description 8
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 8
- 235000008434 ginseng Nutrition 0.000 claims abstract description 8
- 229940112822 chewing gum Drugs 0.000 claims abstract description 5
- 235000015218 chewing gum Nutrition 0.000 claims abstract description 5
- 244000269722 Thea sinensis Species 0.000 claims abstract 8
- 239000000284 extract Substances 0.000 claims description 48
- 241000628997 Flos Species 0.000 claims description 36
- 235000013616 tea Nutrition 0.000 claims description 17
- 235000003935 Hippophae Nutrition 0.000 claims description 12
- 241000229143 Hippophae Species 0.000 claims description 12
- 229930014669 anthocyanidin Natural products 0.000 claims description 12
- 150000001452 anthocyanidin derivatives Chemical class 0.000 claims description 12
- 235000008758 anthocyanidins Nutrition 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 6
- 235000020710 ginseng extract Nutrition 0.000 claims description 6
- 235000015091 medicinal tea Nutrition 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000005202 decontamination Methods 0.000 claims description 3
- 230000003588 decontaminative effect Effects 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims 3
- 238000001816 cooling Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 2
- 240000003870 Ageratum houstonianum Species 0.000 abstract 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 2
- 241001632410 Eleutherococcus senticosus Species 0.000 abstract 2
- 240000006509 Gynostemma pentaphyllum Species 0.000 abstract 2
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 abstract 2
- 240000000950 Hippophae rhamnoides Species 0.000 abstract 2
- 235000003145 Hippophae rhamnoides Nutrition 0.000 abstract 2
- 240000002853 Nelumbo nucifera Species 0.000 abstract 2
- 235000006508 Nelumbo nucifera Nutrition 0.000 abstract 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 abstract 2
- 244000042430 Rhodiola rosea Species 0.000 abstract 2
- 235000003713 Rhodiola rosea Nutrition 0.000 abstract 2
- 235000004338 Syringa vulgaris Nutrition 0.000 abstract 2
- 244000297179 Syringa vulgaris Species 0.000 abstract 2
- 229930002877 anthocyanin Natural products 0.000 abstract 2
- 235000010208 anthocyanin Nutrition 0.000 abstract 2
- 239000004410 anthocyanin Substances 0.000 abstract 2
- 150000004636 anthocyanins Chemical class 0.000 abstract 2
- 229940041616 menthol Drugs 0.000 abstract 2
- 241001122767 Theaceae Species 0.000 description 10
- 206010006326 Breath odour Diseases 0.000 description 7
- 208000032139 Halitosis Diseases 0.000 description 7
- 206010016256 fatigue Diseases 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000007779 soft material Substances 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 235000015096 spirit Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 206010002368 Anger Diseases 0.000 description 1
- 206010057315 Daydreaming Diseases 0.000 description 1
- 241000245240 Lonicera Species 0.000 description 1
- 241001165494 Rhodiola Species 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation with the functions of breath refreshing, spirit improving and fatigue relieving. According to the invention, two compatibility schemes are selected due to the characteristics of the preparation. According to the first scheme, the preparation is composed of lilac, hippophae rhamnoides, gynostemma pentaphyllum, acanthopanax senticosus, ginseng flower, honeysuckle, lotus leaves, ageratum, rhodiola rosea, taurine, tea polyphenols, caffeine, anthocyanins, menthol and leaf active, and can be made into a tea agent. According to the second scheme, the preparation is composed of a lilac extractive, a hippophae rhamnoides extractive, a gynostemma pentaphyllum extractive, an acanthopanax senticosus extractive, a ginseng flower extractive, a honeysuckle extractive, a lotus leaf extractive, an ageratum extractive, a rhodiola rosea extractive, taurine, tea polyphenols, caffeine, anthocyanins, menthol and leaf active, and can be made into a tablet, a chewing gum and the like. The preparation has the significant functions of breath refreshing, spirit improving and fatigue relieving.
Description
The present invention is a kind of fresh breath, the preparation that improves spirit, fatigue alleviating.It can be made into the dosage forms such as medicinal tea, tablet, chewing gum.
So-called implication is abnormal, the improper abnormal smells from the patient (being commonly called as " halitosis ") coming out from population exactly.Allow people's close contact with it, affect normal human communication, make party very worried.Causing very large negative effect to the daily life of people, and owing to there being the people of halitosis, be no longer subject to companions' welcome, so treated coldly gradually, is also very large impact on its psychology.
This impact is omnibearing, student can affect study, adolescent can affect love and make friends, businessperson can affect commercial intercourse, salesman can affect the communication with client, if common office worker also can have influence on because of halitosis the work of oneself, be both that man and wife also can become estranged with exchanging day by day because halitosis has influence on emotion between man and wife.Halitosis everywhere can be on people's impact thus, hard to guard against, and therefore many people lack confidence, feel oneself inferior unsociable and eccentric, lose the willpower, temperament and interest, intelligence and the vitality that originally have.
This is in the epoch with keen competition, and it is the prerequisite of working well that energetic, attention is concentrated, and a lot of people's lassitude, dispirited fatigue are done things out of spirits, can not concentrate one's energy, thereby has affected oneself cause, contacts etc.Many irreversible serious consequences are caused.
The present invention is on clinical practice basis for many years, constantly sums up to improve and improves the desirable preparation being developed into.Through clinical observation, in conjunction with people's actual needs, with medicated tea etc., for treating means, effective percentage reaches 100%.
Medicine of the present invention is by scheme one: Flos Caryophylli, Fructus Hippophae, Herb Gynostemmae Pentaphylli, Radix Et Caulis Acanthopanacis Senticosi, Flos Ginseng, Flos Lonicerae, Folium Nelumbinis, Herba Pogostemonis, Radix Rhodiolae, taurine, tea polyphenols, caffeine, anthocyanidin, Mentholum, the leaf element of living forms.Scheme two: Flos Caryophylli extract, Fructus Hippophae extract, Herb Gynostemmae Pentaphylli extract, Radix Et Caulis Acanthopanacis Senticosi extract, Flos Ginseng's extract, Flos Lonicerae extract, Folium Nelumbinis extract, Herba Pogostemonis extract, Radix Rhodiolae extract, taurine, tea polyphenols, caffeine, anthocyanidin, Mentholum, leaf are lived plain composition.
Ingredients scope of the present invention is:
Scheme one:
Flos Caryophylli 1-3 gram Fructus Hippophae 3-9 gram Herb Gynostemmae Pentaphylli 15-30 gram of Radix Et Caulis Acanthopanacis Senticosi 6-9 gram
Flos Ginseng 1-9 gram Flos Lonicerae 10-30 gram Folium Nelumbinis 6-10 gram of Herba Pogostemonis 6-10 gram
Radix Rhodiolae 6-10 gram taurine 3-15 gram tea polyphenols 6-15 gram of caffeine 1-2 gram
Anthocyanidin 5-20 gram of Mentholum 1-2 gram of leaf plain 5-15 gram alive.
Scheme two:
Flos Caryophylli extract 1-3 gram of Fructus Hippophae extract 1-9 gram of Herb Gynostemmae Pentaphylli extract 5-10 gram
1-9 gram of Flos Lonicerae extract 5-9 gram of Radix Et Caulis Acanthopanacis Senticosi extract 1-6 gram of Flos Ginseng's extract
Folium Nelumbinis extract 1-9 gram of Herba Pogostemonis extract 1-9 gram of Radix Rhodiolae extract 2-10 gram
Taurine 3-15 gram tea polyphenols 6-15 gram caffeine 1-2 gram of anthocyanidin 5-20 gram
Mentholum 1-2 gram of leaf plain 5-15 gram alive.
The present invention's each component weight proportion of filling a prescription is:
Scheme one:
Flos Caryophylli 3% Fructus Hippophae 9% Herb Gynostemmae Pentaphylli 15% Radix Et Caulis Acanthopanacis Senticosi 8% Flos Ginseng 6%
Flos Lonicerae 10% Folium Nelumbinis 6% Herba Pogostemonis 6% Radix Rhodiolae 6% taurine 9%
Tea polyphenols 10% caffeine 1% anthocyanidin 5% Mentholum 1%
Leaf lives plain 5%.
Scheme two:
Flos Caryophylli extract 3% Fructus Hippophae extract 9% Herb Gynostemmae Pentaphylli extract 10%
Radix Et Caulis Acanthopanacis Senticosi extract 6% Flos Ginseng's extract 9% Flos Lonicerae extract 7%
Folium Nelumbinis extract 8% Herba Pogostemonis extract 7% Radix Rhodiolae extract 10%
Taurine 9% tea polyphenols 10% caffeine 1% anthocyanidin 5%
Mentholum 1% leaf lives plain 5%.
The processing technique of medicine medicinal tea of the present invention is:
The medicine of scheme one formula ratio is chosen to decontamination, oven dry, pulverizing, mixing and sieve, pack in sterilising filtration tea bag, seal and get final product.On tea bag, carry short-term with leading.
Medicine of the present invention, except making above-mentioned medicinal tea, can also be made conventional pharmaceutical dosage form, as tablet, chewing gum etc.
Tablet producing technology of the present invention:
The medicine of scheme two formula ratios and adjuvant are pulverized, crossed 80 mesh sieve mix homogeneously, add appropriate wetting agent to stir and make soft material, soft material is crossed to screen cloth and obtain wet granular, by wet grain drying, sieve, carry out granulate processing, add lubricant, disintegrating agent, tabletting, both.
Typical case:
What XX Nv28Sui Mou company salesman, should be halitosis and feels oneself inferior, and dare not talk with people, so its achievement is always bad, makes her be sorely distressed.Take after this product, start optimism, the confidence of change, performance is very outstanding in print, has now become sales manager.
Zhao XX boy in high school, has a hunch that there is strange taste in the oral cavity of oneself recently, and very friend always feels uneasy together at ordinary times, thinks that halitosis is because of hereditary cause, and temper is irascible gradually, and what father and mother were sayed is disrespectful, and classmate is shied away.Father and mother are also usually anxious for it, worry that this defect can have influence on his marriage and cause.After take this product one week after situation be clearly better, no longer jump on someone, become optimistic, generous, study is also constantly progressive.
34 years old taxi driver of Lee X man, when driving, always feel exhausted, out of spirits, absent minded, and passenger often disputes, family members worries him very much.Take after this product a period of time, feel that energetic, attention concentrates, can be safely, drive on schedule, household and other people have originally had the security.
Embodiment:
Scheme one:
1 kilogram of leaf of 5 kilograms of Mentholums of 1 kilogram of anthocyanidin of 10 kilograms of caffeine of 9 kilograms of tea polyphenols of 6 kilograms of taurines of 6 kilograms of Radix Rhodiolaes of 6 kilograms of Herba Pogostemoniss of 10 kilograms of Folium Nelumbinis of 6 kilograms of Flos Loniceraes of 8 kilograms of Flos Ginseng of 15 kilograms of Radix Et Caulis Acanthopanacis Senticosis of 9 kilograms of Herb Gynostemmae Pentaphylli of 3 kilograms of Fructus Hippophaes of Flos Caryophylli is lived plain 5 kilograms.
Scheme two:
1 kilogram of leaf of 5 kilograms of Mentholums of 1 kilogram of anthocyanidin of 10 kilograms of caffeine of 9 kilograms of tea polyphenols of 10 kilograms of taurines of 7 kilograms of Radix Rhodiolae extracts of 8 kilograms of Herba Pogostemonis extract of 7 kilograms of Folium Nelumbinis extracts of 9 kilograms of Flos Lonicerae extracts of 6 kilograms of Flos Ginseng's extracts of 10 kilograms of Radix Et Caulis Acanthopanacis Senticosi extracts of 9 kilograms of Herb Gynostemmae Pentaphylli extracts of 3 kilograms of Fructus Hippophae extracts of Flos Caryophylli extract is lived plain 5 kilograms.
Such scheme one crude drug is chosen to decontamination, oven dry, pulverizes, sieved, and the filtration paper bag that packs sterilizing into obtains teabag finished product.
Such scheme two raw materials and adjuvant are pulverized, crossed 80 mesh sieve mix homogeneously, add appropriate wetting agent to stir and make soft material, soft material is crossed to screen cloth and obtain wet granular, by wet grain drying, sieve, carry out granulate processing, add lubricant, disintegrating agent, tabletting, both.
Claims (6)
1. a preparation for fresh breath, raising spirit, fatigue alleviating, is characterized in that the content range of this ingredients composition is:
Scheme one:
Flos Caryophylli 1-3 gram Fructus Hippophae 3-9 gram Herb Gynostemmae Pentaphylli 15-30 gram of Radix Et Caulis Acanthopanacis Senticosi 6-9 gram
Flos Ginseng 1-9 gram Flos Lonicerae 10-30 gram Folium Nelumbinis 6-10 gram of Herba Pogostemonis 6-10 gram
Radix Rhodiolae 6-10 gram taurine 3-15 gram tea polyphenols 6-15 gram of caffeine 1-2 gram
Anthocyanidin 5-20 gram of Mentholum 1-2 gram of leaf plain 5-15 gram alive.
Scheme two:
Flos Caryophylli extract 1-3 gram of Fructus Hippophae extract 1-9 gram of Herb Gynostemmae Pentaphylli extract 5-10 gram
1-9 gram of Flos Lonicerae extract 5-9 gram of Radix Et Caulis Acanthopanacis Senticosi extract 1-6 gram of Flos Ginseng's extract
Folium Nelumbinis extract 1-9 gram of Herba Pogostemonis extract 1-9 gram of Radix Rhodiolae extract 2-10 gram
Taurine 3-15 gram tea polyphenols 6-15 gram caffeine 1-2 gram of anthocyanidin 5-20 gram
Mentholum 1-2 gram of leaf plain 5-15 gram alive.
2. medicine according to claim 1, is characterized in that each component percentage by weight is:
Scheme one:
Flos Caryophylli 3% Fructus Hippophae 9% Herb Gynostemmae Pentaphylli 15% Radix Et Caulis Acanthopanacis Senticosi 8% Flos Ginseng 6%
Flos Lonicerae 10% Folium Nelumbinis 6% Herba Pogostemonis 6% Radix Rhodiolae 6% taurine 9%
Tea polyphenols 10% caffeine 1% anthocyanidin 5% Mentholum 1%
Leaf lives plain 5%.
Scheme two:
Flos Caryophylli extract 3% Fructus Hippophae extract 9% Herb Gynostemmae Pentaphylli extract 10%
Radix Et Caulis Acanthopanacis Senticosi extract 6% Flos Ginseng's extract 9% Flos Lonicerae extract 7%
Folium Nelumbinis extract 8% Herba Pogostemonis extract 7% Radix Rhodiolae extract 10%
Taurine 9% tea polyphenols 10% caffeine 1% anthocyanidin 5%
Mentholum 1% leaf lives plain 5%.
3. medicine according to claim 1 and 2, is characterized in that it is medicinal tea, tablet, chewing gum dosage form.
4. the preparation method of medicinal tea according to claim 3, is characterized in that the medicine of scheme one formula ratio to choose decontamination, dries, pulverizes, mixes and sieve, and packs in sterilising filtration tea bag, seals and get final product, and on tea bag, carries short-term with leading.
5. the preparation method of tablet according to claim 3, is characterized in that the crude drug of scheme two formula ratios to be ground into fine powder, with auxiliary materials and mixing, granulates, and puts 60-802 dry.Granulate, tabletting, both.
6. the preparation method of chewing gum according to claim 3, is characterized in that the crude drug of formula ratio to be ground into fine powder, and gum base is softening, with above-mentioned pulverizing be fine powder crude drug mediation, extruding, cooling, molded, cutting, both.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210436913.9A CN103800562A (en) | 2012-11-06 | 2012-11-06 | Preparation with functions of breath refreshing, spirit improving and fatigue relieving |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210436913.9A CN103800562A (en) | 2012-11-06 | 2012-11-06 | Preparation with functions of breath refreshing, spirit improving and fatigue relieving |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103800562A true CN103800562A (en) | 2014-05-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210436913.9A Pending CN103800562A (en) | 2012-11-06 | 2012-11-06 | Preparation with functions of breath refreshing, spirit improving and fatigue relieving |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103800562A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2495565A1 (en) * | 2014-06-10 | 2014-09-17 | José Luis ROJANO JORGE | Composition to make chewing gums (Machine-translation by Google Translate, not legally binding) |
| CN104171243A (en) * | 2014-08-23 | 2014-12-03 | 柯金表 | Chewing gum with effects of eliminating fatigue, refreshing, benefiting heart and increasing intelligence |
| CN105639000A (en) * | 2015-12-30 | 2016-06-08 | 骆勇 | Herbal tea capable of freshening breath |
| CN107259246A (en) * | 2017-07-11 | 2017-10-20 | 辛卓霖 | A kind of cloves mint beverage and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1631247A (en) * | 2005-01-20 | 2005-06-29 | 北京科信必成医药科技发展有限公司 | Health food with hypoxia preventing and anti-fatigue function and preparation technique thereof |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
| CN102068499A (en) * | 2011-01-18 | 2011-05-25 | 夏运喜 | Buccal traditional Chinese medicine for removing oral malodor and preparation method thereof |
-
2012
- 2012-11-06 CN CN201210436913.9A patent/CN103800562A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1631247A (en) * | 2005-01-20 | 2005-06-29 | 北京科信必成医药科技发展有限公司 | Health food with hypoxia preventing and anti-fatigue function and preparation technique thereof |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
| CN102068499A (en) * | 2011-01-18 | 2011-05-25 | 夏运喜 | Buccal traditional Chinese medicine for removing oral malodor and preparation method thereof |
Non-Patent Citations (3)
| Title |
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| 凌关庭: "《保健食品原料手册 第二版》", 31 May 2007 * |
| 原毅军: "《微观经济学》", 30 June 2010 * |
| 贾冬英等: "《食养与食疗教程》", 30 November 2011 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2495565A1 (en) * | 2014-06-10 | 2014-09-17 | José Luis ROJANO JORGE | Composition to make chewing gums (Machine-translation by Google Translate, not legally binding) |
| WO2015189445A1 (en) * | 2014-06-10 | 2015-12-17 | Wug Functional Gums, S.L. | Composition for producing chewing gum |
| CN104171243A (en) * | 2014-08-23 | 2014-12-03 | 柯金表 | Chewing gum with effects of eliminating fatigue, refreshing, benefiting heart and increasing intelligence |
| CN105639000A (en) * | 2015-12-30 | 2016-06-08 | 骆勇 | Herbal tea capable of freshening breath |
| CN107259246A (en) * | 2017-07-11 | 2017-10-20 | 辛卓霖 | A kind of cloves mint beverage and preparation method thereof |
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Application publication date: 20140521 |
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