CN103735833B - A kind of medicine for the treatment of children alopecia and preparation method thereof - Google Patents
A kind of medicine for the treatment of children alopecia and preparation method thereof Download PDFInfo
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Abstract
Description
技术领域 technical field
本发明涉及一种治疗小儿脱发的药物及其制备方法,属中药领域。 The invention relates to a medicine for treating hair loss in children and a preparation method thereof, belonging to the field of traditional Chinese medicines.
技术背景 technical background
小儿期常见的脱发是后天性脱发,大多由于受惊吓、恐惧或营养不均衡,从而引起机体代谢失常、内分泌紊乱,导致脱发。由于目前西药无法有效治疗小儿脱发,因此人们对快速有效治疗小儿脱发的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。 The common hair loss in children is acquired hair loss, most of which are caused by fright, fear or nutritional imbalance, which cause metabolic disorders and endocrine disorders, leading to hair loss. Because western medicine can't effectively treat children's alopecia at present, so people have great demand to the Chinese medicine medicine of rapid and effective treatment children's alopecia, so far, also do not find relevant report about the present invention.
发明内容 Contents of the invention
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗小儿脱发的药物,从而完成了本发明。 The present inventor has finally found the medicine for effectively treating children's alopecia based on the research of TCM theory and the repeated verification of clinical trials, thereby completing the present invention.
本发明的目的就是提供一种更有效的治疗小儿脱发的中药组合药物。 The purpose of the present invention is to provide a more effective traditional Chinese medicine combination medicine for treating hair loss in children.
本发明的另一目的就是提供了该中药组合药物的制备方法。 Another object of the present invention is to provide a preparation method of the traditional Chinese medicine combination medicine.
本发明药物是选择麦冬、白芷、生地黄、墨旱莲、当归、白芍、红花、补骨脂、女贞子、黄芪、大枣、侧柏叶、桑叶、玄参、党参、阿胶、龙眼肉、肉苁蓉、虎杖、黄柏、菟丝子、乌药、制首乌、山楂、鸡内金、佛手柑、丹参、牡丹皮、甘草、桑椹、黑芝麻、紫河车药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗小儿脱发。其中选用麦冬是因为其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的功能,治肺燥干咳,吐血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿,止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用墨旱莲是因为其性味苦酸,凉,入肝、肾经,有凉血,止血,补肾,益阴的功能,治吐血,咳血,衄血,尿血,便血,血痢,刀伤出血,须发早白,白喉,淋浊,滞下,阴部湿痒。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血活血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用补骨脂是因为其性味辛,温,入肾经,有补肾助阳的功能,治肾虚冷泻,遗尿,滑精,小便频数,阳痿,腰膝冷痛,虚寒喘嗽,外用治白癜风。选用女贞子是因为其性味苦甘,平,入肝、肾经,有补肝肾,强腰膝的功能,治阴虚内热,头晕,目花耳鸣,腰膝酸软,须发早白。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益气的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用大枣是因为其性味甘,温,入脾、胃经,有补脾和胃,益气生津,调营卫,解药毒的功能,治胃虚食少,脾弱便溏,气血津液不足,营卫不和,心悸怔忡,妇人脏躁。选用侧柏叶是因为其性味苦涩,寒,入心、肝、大肠经,有凉血,止血,祛风湿,散肿毒的功能,治吐血,衄血,尿血,血痢,肠风,崩漏,风湿痹痛,细菌性痢疾,高血压,咳嗽,丹毒,痄腮,烫伤。选用桑叶是因为其性味苦甘,寒,入肺、肝经,有祛风清热,凉血明目的功能,治风湿发热,头痛,目赤,口渴,肺热咳嗽,风痹,瘾疹,下肢象皮肿。选用玄参是因为其性味苦,咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治热病烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用阿胶是因为其性味甘,平,入肺、肝、肾经,有滋阴补血,安胎的功能,治血虚,虚劳咳嗽,吐血、衄血、便血,妇女月经不调,崩中,胎漏。选用龙眼肉是因为其性味甘,温,入心、脾经,有益心脾,补气血,安神的功能,治虚功羸弱,失眠,健忘,惊悸,怔仲。选用肉苁蓉是因为其性味甘酸咸,温,入肾、大肠经,有补肾,益精,润燥,清肠的功能,治男子阳痿,女子不孕,带下,血崩,腰膝冷痛,血枯便秘。选用虎杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能,治风湿筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用黄柏是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用菟丝子是因为其性味辛甘,平,入肝、肾经,有补肝肾,益精髓,明目的功能,治腰膝酸痛,遗精,消渴,尿有余沥,目暗。选用乌药是因为其性味辛,温,入脾、肺、肾、膀胱经,有顺气,开郁,散寒,止痛的功能,治气逆胸腹胀痛,宿食不满,反胃吐食,寒疝,脚气,小便频数。选用何首乌是因为其性味苦甘涩,微温,入肝、肾经,有补肝,益肾,养血,祛风的功能,治肝肾阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,遗精,崩带,久疟,久痢,慢性肝炎,痈肿,瘰疬,肠风,痔疾。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用鸡内金是因为其性味甘,平,入脾、胃经,有治积滞,健脾胃的功能,治食积胀满,呕吐反胃,泻痢,疳积,消渴,遗溺,喉痹乳蛾,牙疳口疮。选用佛手柑,异名佛手、佛手香橼,是因为其性味辛苦酸,温,入肝、胃经,有理气,化痰的功能,治胃痛,胁胀,呕吐,噎膈,痰饮咳喘,并能解酒。选用丹参是因为其性味苦,微温,入心、肝经,有活血祛痰,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,经闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用桑椹是因为其性味甘,寒,入肝,肾经,有补肝,益肾,熄风,滋液的功能,治肝肾阴亏,消渴,便秘,目暗,耳鸣,瘰疬,关节不利。选用黑芝麻,异名胡麻仁,其性味甘,平,归肝、肾、大肠经,有补肝肾,益精血,润肠燥的功能,治头昏眼花,耳鸣耳聋,须发早白,病后脱发,肠燥便秘。选用紫河车是因为其性味甘咸,温,入肺、肝、肾经,有补气,养血,益精的功能,治虚损,羸瘦,劳热骨蒸,咳喘,咯血,盗汗,遗精,阳痿,妇女血气不足,不孕或乳少。 The medicine of the present invention is to select Ophiopogon japonicus, Angelica dahurica, Rehmannia glutinosa, Eclipta, Angelica, Radix Paeoniae Alba, Safflower, Psoralen, Ligustrum lucidum, Astragalus, jujube, cypress leaves, mulberry leaves, Scrophulariae, Codonopsis, Donkey-hide gelatin, longan meat, Cistanche, Polygonum cuspidatum, Cortex Phellodendri, Cuscuta, Wuyao, Zhishouwu, Hawthorn, Gallinaceae, Bergamot, Salvia miltiorrhiza, Moutan bark, licorice, mulberry, black sesame, Ziheche drugs are prepared in combination, The combination of these medicines makes the efficacy of each medicine produce a synergistic effect, so that children's hair loss can be effectively treated. Wherein select Ophiopogon japonicus because its nature and flavor are sweet and slightly bitter, cold, enter lung, stomach, heart meridian, have the function of nourishing yin and moistening lung, clearing away heart-fire and eliminating troubles, benefiting stomach and promoting body fluid, controlling dryness of the lung and dry cough, hematemesis, hemoptysis, lung impotence, Pulmonary carbuncle, asthenia, vexation and heat, thirst, fever and fluid injury, dry throat and mouth, constipation. Select Angelica dahurica to be because its nature and flavor are pungent, warm, enter lung, spleen, stomach meridian, have expelling wind, dampness, detumescence, pain relieving function, control headache, brow bone pain, toothache, nasal sinusitis, cold-damp abdominal pain , Intestinal wind and hemorrhoids, red and white vaginal discharge, carbuncle sores, dry itchy skin, scabies. Select Radix Rehmanniae to be because its nature and flavor are sweet, cold, return home, liver, kidney meridian, have heat-clearing and cooling blood, nourishing yin, the function of promoting body fluid, controls pyretic disease polydipsia, internal heat due to yin deficiency, bone steaming labor heat, internal heat is quenched one's thirst, Hematemesis, epistaxis, macule eruption. Select Eclipta is because its nature and flavor are bitter and sour, cool, enter liver, kidney meridian, have cooling blood, hemostasis, kidney tonifying, the function of benefiting yin, control vomiting blood, hemoptysis, epistaxis, hematuria, hematochezia, bloody dysentery, knife. Hemorrhage due to injury, premature graying of beard and hair, diphtheria, stranguria, stagnation, wet and itchy genitals. Angelica sinensis is selected because its nature and flavor are sweet and pungent, warm, enter the heart, liver, and spleen meridian, and have the functions of enriching blood and promoting blood circulation, regulating menstruation and relieving pain, moistening dryness and smoothing the intestines, and can treat irregular menstruation, amenorrhea, abdominal pain, lump in the abdomen, metrorrhagia, Blood deficiency headache, dizziness, impotence, intestinal dryness and difficulty defecation, red dysentery followed by heavy, carbuncle sores, gold sores, injury from falls. Select Radix Paeoniae Alba to be because its nature and flavor bitter sour, cool, enter liver, spleen meridian, have nourishing blood and softening liver, slow middle pain relieving, the function of astringing yin and sweating, controls chest and abdomen hypochondriac pain, dysentery abdominal pain, spontaneous sweating and night sweats , fever due to yin deficiency, irregular menstruation, metrorrhagia, leucorrhea. Select safflower to be because its nature and flavor are pungent, warm, enter the heart, liver meridian, have the function of promoting blood circulation to stimulate menstruation, removing blood stasis and relieving pain, and can treat amenorrhea, lump in the abdomen, dystocia, stillbirth, postpartum lochia, pain caused by blood stasis, carbuncle. , fall injury. Select Psoraleae to be because its nature and flavor are pungent, warm, enter the kidney meridian, have the function of invigorating the kidney and yang, control cold diarrhea due to kidney deficiency, enuresis, slippery sperm, frequent urination, impotence, cold pain in the waist and knees, dyspnea and cough due to deficiency cold, external application Vitiligo. Select Fructus Ligustrum to be because its nature and flavor bitter-sweet, flat, enter liver, kidney channel, have the function of invigorating liver and kidney, strengthening waist and knees, control yin deficiency and internal heat, dizziness, blurred vision and tinnitus, soreness of waist and knees, premature graying of beard and hair. Select Radix Astragali to be because its nature and flavor are sweet, lukewarm, enter lung, spleen meridian, raw use is beneficial to defend and solidify exterior, diuresis detumescence, detoxification, the function of muscle regeneration, controls spontaneous perspiration, night sweat, arthralgia due to blood, edema, carbuncle ulcer does not ulcerate Or collapse for a long time; Sunburn has the function of invigorating the middle and replenishing qi, treating internal injuries and fatigue, spleen deficiency and diarrhea, prolapse of the anus, qi deficiency and blood loss, collapse and all symptoms of qi deficiency and blood deficiency. Jujube is selected because its nature and flavor are sweet and warm, enter the spleen and stomach meridians, have the functions of invigorating the spleen and harmonizing the stomach, nourishing qi and promoting body fluid, regulating the camp and health, and detoxifying the poison. Insufficient blood and body fluid, disharmony between the camp and the guard, palpitations and palpitations, and the woman is dirty. Selecting Radix Arborvitae is to be because its nature and flavor are bitter, cold, enters heart, liver, large intestine channel, has cooling blood, hemostasis, rheumatism dispelling, the function of dispelling swollen poison, controls hematemesis, epistaxis, hematuria, bloody dysentery, intestinal wind, Metrorrhagia, rheumatic arthralgia, bacillary dysentery, high blood pressure, cough, erysipelas, mumps, burns. Select mulberry leaf to be to be because its nature and flavor are bitter-sweet, cold, enter lung, Liver Channel, have expelling wind and heat-clearing, cooling blood and improving eyesight function, control rheumatic fever, headache, conjunctival congestion, thirsty, lung-heat cough, arthralgia due to wind, addiction. Rash, elephantiasis of lower extremities. Scrophulariaceae is selected because of its nature and flavor bitter, salty, cool, into the lungs, kidney meridian, has the functions of nourishing yin, lowering fire, eliminating annoyance, detoxification, curing fever, polydipsia, spots, bone steaming, labor heat, night sleepiness Restless, spontaneous sweating, constipation due to Tianjin injury, vomiting blood and epistaxis, sore throat, carbuncle, scrofula. Codonopsis Codonopsis is selected because its nature and flavor are sweet and flat, and it divides Qi into the hands and foot Taiyin meridians. , prolapse of the anus. Select donkey-hide gelatin to be because its nature and flavor are sweet, flat, enter lung, liver, kidney meridian, have nourishing yin and nourishing blood, antiabortive function, control blood deficiency, consumptive cough, hematemesis, epistaxis, blood in stool, women's irregular menstruation, metrorrhagia. In, fetal leakage. Select longan meat to be because its nature and flavor are sweet, warm, go into the heart, spleen meridian, benefit the heart and spleen, nourish qi and blood, calm the nerves, and treat weakness, insomnia, forgetfulness, palpitations, and convulsions. Cistanche Herba is selected because its nature and taste are sweet, sour, salty, warm, enters the kidney and large intestine meridian, has the functions of nourishing the kidney, nourishing essence, moistening dryness, and clearing the intestines, and can treat impotence in men, infertility in women, vaginal discharge, metrorrhagia, cold pain in the waist and knees, Blood dry constipation. Polygonum cuspidatum is selected because its nature and flavor are bitter, flat, and has the functions of expelling wind, promoting dampness, dispelling blood stasis, and dredging menstruation. , bleeding from hemorrhoids, injury from falls, burns, malignant sores and ringworm. Phellodendron Phellodendri is selected to be because its nature and flavor are bitter, cold, enters lung, stomach, kidney meridian, has the function of nourishing yin and reducing fire, moistening dryness and smoothing intestines, curing dysphoria and thirst, bone steaming and labor heat, cough due to lung heat, and dry stool , Difficulty urinating. Select Cuscuta Semen to be because its nature and flavor are pungent and sweet, flat, enter the liver and kidney channels, have the functions of nourishing the liver and kidney, benefiting the essence, improving eyesight, and controlling soreness of the waist and knees, nocturnal emission, quenching one's thirst, urination with urination, dark eyesight. Select black medicine because its nature and flavor are pungent, warm, enter spleen, lung, kidney, urinary bladder meridian, have the functions of smoothing qi, dispelling depression, dispersing cold, and relieving pain, controlling qi inverse chest and abdominal distention, dissatisfaction with food, nausea and vomiting , cold hernia, beriberi, frequent urination. Polygonum multiflorum is selected because its nature and flavor are bitter, sweet and astringent, slightly warm, enters the liver and kidney meridians, has the functions of nourishing the liver, nourishing the kidney, nourishing blood, and expelling wind. Weak knees, sore muscles and bones, nocturnal emission, metrorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, intestinal wind, hemorrhoids. Hawthorn is selected because of its sweet and sour nature and mild temperature, enters the spleen, stomach and liver meridian, has the function of eliminating food accumulation, dissipating blood stasis, and expelling tapeworms. Dysentery, intestinal wind, low back pain, hernia, pillow pain in postpartum children, endless lochia, stagnation of milk and food in children. Select gallinaceous gold to be because its nature and flavor are sweet, flat, enter spleen, stomach meridian, have and control stagnation, the function of invigorating spleen and stomach, controls food stagnation fullness, vomiting regurgitation, dysentery, malnutrition, quench one's thirst, drowning, sore throat. Arthralgia milk moth, dental malnutrition aphthous sore. Select bergamot, synonymous bergamot, bergamot citron, because its nature and taste are bitter and sour, warm, enter the liver and stomach meridian, have the functions of regulating qi and resolving phlegm, and can treat stomach pain, abdominal distension, vomiting, choking diaphragm, phlegm retention and cough Breathe, and can hangover. Salvia miltiorrhiza is selected because its nature and flavor are bitter, slightly warm, enters the heart and liver meridian, has the functions of promoting blood circulation and eliminating phlegm, tranquilizing the mind, draining pus, and relieving pain, and can treat angina pectoris, irregular menstruation, dysmenorrhea, amenorrhea, metrorrhagia and vaginal discharge. Lump in the abdomen, accumulation, abdominal pain due to blood stasis, arthralgia, palpitation with fear and insomnia, malignant sore swollen toxin. Cortex Moutan is selected to be because its nature and flavor are hard, cool, enter heart, liver, kidney channel, have heat-clearing, cooling blood, harmonize blood, the function of eliminating stasis, control heat to enter blood system, freckle, convulsion, vomiting, bleedin', Hematochezia, bone steaming and labor-heat, amenorrhea, lump in the abdomen, carbuncle and ulcer, flutter damage. Licorice root is selected because its nature and taste are sweet and flat, and it enters the spleen, stomach, and lung meridian. Lung impotence, cough, palpitation, carbuncle, used raw to treat sore throat, peptic ulcer, carbuncle sore, antidote poison and food poisoning. Mulberry fruit is selected because its nature and flavor are sweet and cold, enter the liver and kidney meridian, have the functions of nourishing the liver, nourishing the kidney, quenching the wind, and nourishing the liquid, and can cure liver and kidney yin deficiency, thirst, constipation, dark eyes, tinnitus, and scrofula , Joint disadvantage. Choose black sesame seeds, synonymous with flax seed, its nature and flavor are sweet, flat, and it returns to the liver, kidney, and large intestine meridian. , hair loss after illness, intestinal dryness and constipation. Ziheche is selected because of its sweet and salty nature, warm, enters the lung, liver, and kidney meridians, has the functions of invigorating qi, nourishing blood, and benefiting essence, and can treat deficiency, emaciation, fatigue, hot bones, cough, asthma, and hemoptysis , night sweats, nocturnal emission, impotence, women's blood deficiency, infertility or less milk.
具体实施方式 Detailed ways
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述用量范围内都具有较好的疗效 The drug dosage of the components of the present invention is also obtained by the inventor after a lot of exploration, and the dosage of each component has a good curative effect within the following dosage range
麦冬6-15克白芷5-15克生地黄8-20克 Ophiopogon japonicus 6-15 grams Angelica dahurica 5-15 grams Raw rehmannia 8-20 grams
墨旱莲6-16克当归8-18克白芍8-18克 Eclipta 6-16g Angelica 8-18g Paeoniae Alba 8-18g
红花4-12克补骨脂6-15克女贞子8-20克 4-12 grams of safflower 6-15 grams of psoraleae 8-20 grams of privet fruit
黄芪6-16克大枣2-4枚侧柏叶8-15克 Astragalus 6-16 grams Jujube 2-4 pieces of oriental cypress leaves 8-15 grams
桑叶6-18克玄参4-12克党参5-12克 Mulberry leaves 6-18 grams Scrophulariaceae 4-12 grams Codonopsis 5-12 grams
阿胶4-10克龙眼肉5-10克肉苁蓉8-16克 4-10 grams of donkey-hide gelatin Longan meat 5-10 grams Cistanche 8-16 grams
虎杖5-12克黄柏6-12克菟丝子5-15克 Knotweed 5-12 grams Phellodendron 6-12 grams Dodder 5-15 grams
乌药5-12克制首乌4-12克山楂6-15克 Wuyao 5-12g restrains Shouwu 4-12g Hawthorn 6-15g
鸡内金6-15克佛手柑5-12克丹参6-15克 Chicken Gold 6-15g Bergamot 5-12g Salvia 6-15g
牡丹皮4-12克甘草2-8克桑椹5-12克 Moutan bark 4-12g Licorice 2-8g Mulberry 5-12g
黑芝麻8-20克紫河车8-18克 Black sesame 8-20 grams Ziheche 8-18 grams
优选为 preferably
麦冬8克白芷8克生地黄10克 Ophiopogon japonicus 8 grams Angelica dahurica 8 grams Raw rehmannia 10 grams
墨旱莲12克当归10克白芍10克 Mo Eclipta 12g Angelica 10g Paeoniae Alba 10g
红花5克补骨脂10克女贞子10克 5 grams of safflower 10 grams of psoralen 10 grams of Ligustrum lucidum
黄芪8克大枣3枚侧柏叶10克 Astragalus 8 grams Jujube 3 pieces of oriental cypress leaves 10 grams
桑叶10克玄参8克党参10克 10 grams of mulberry leaves, 8 grams of Scrophulariaceae, 10 grams of Dangshen
阿胶8克龙眼肉8克肉苁蓉10克 8 grams of donkey-hide gelatin Longan meat 8 grams Cistanche 10 grams
虎杖8克黄柏8克菟丝子8克 8 grams of Polygonum cuspidatum 8 grams of Cuscuta 8 grams
乌药8克制首乌8克山楂9克 8 grams of Wuyao, 8 grams of Shouwu, 9 grams of Hawthorn
鸡内金10克佛手柑10克丹参8克 10 grams of Chicken Neijin 10 grams of Bergamot 8 grams of Salvia
牡丹皮8克甘草3克桑椹10克 8 grams of peony bark 3 grams of licorice 10 grams of mulberries
黑芝麻10克紫河车10克 10 grams of black sesame seeds 10 grams of purple river car
本发明药物的制备方法如下 The preparation method of medicine of the present invention is as follows
一、备料 1. Preparation
1、麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; 1. Ophiopogon japonicus: pick out impurities, soak in water, remove, remove the heart after moistening, then wash and dry;
2、白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥; 2. Angelica dahurica: remove impurities, wash with water, soak, remove and moisten thoroughly, and dry until the outer skin has no greasy feeling, then dry the slices after moistening;
3、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑; 3. Rehmannia glutinosa: Take the raw medicinal materials, remove impurities, wash, moisten slightly, cut into thick slices, dry, and sieve to remove debris;
4、墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干; 4. Eclipta: pick out impurities, remove residual roots, wash thoroughly, cut into sections and dry in the sun;
5、当归:拣去杂质,洗净,闷润,稍晾,切片晒干; 5. Angelica sinensis: remove impurities, wash, moisten, dry for a while, slice and dry;
6、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥; 6. Radix Paeoniae Alba: Remove impurities, separate the large and small pieces, soak in water until 80% transparent, remove, dry in the sun, moisten until the internal and external humidity is even, slice, and dry;
7、红花:拣净杂质,除去茎叶、蒂头,晒干; 7. Safflower: pick out the impurities, remove the stems, leaves and pedicles, and dry them in the sun;
8、补骨脂:簸净杂质,洗净,晒干; 8. Psoraleae: shake off impurities, wash and dry;
9、女贞子:拣去杂质,洗净,晒干; 9. Ligustrum lucidum: pick out impurities, wash and dry;
10、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干; 10. Radix Astragali: Clean the impurities, remove the residual roots and larger hollow roots, soak them in water, remove them, slice them in time after moistening, and dry them in the sun;
11、大枣:拣净杂质,晒干; 11. Jujube: pick out impurities and dry them in the sun;
12、侧柏叶:拣净杂质,揉碎去梗,筛净灰屑; 12. Arborvitae leaves: pick out the impurities, crush and remove the stems, and sieve the ashes;
13、桑叶:拣去杂质,搓碎,簸去梗,筛去泥屑; 13. Mulberry leaves: pick out impurities, crush, winnow to remove stems, and sieve to remove debris;
14、玄参:拣净杂质,除去芦头,洗净润透,切片,晾干; 14. Scrophulariaceae: clean the impurities, remove the reed head, wash and moisten thoroughly, slice and dry;
15、党参:洗净泥沙后润透去芦,切片或切段,晒干; 15. Codonopsis pilosula: wash the sediment and moisten thoroughly to remove the reeds, slice or cut into sections, and dry in the sun;
16、阿胶:捣碎用; 16. Donkey-hide gelatin: for mashing;
17、龙眼肉:取原药材,除去杂质; 17. Longan meat: take raw medicinal materials and remove impurities;
18、肉苁蓉:拣净杂质,清水浸泡,每天换水1—2次,如系咸苁蓉,泡尽盐分,润透,纵向切片,晒干; 18. Cistanche deserticola: pick out impurities, soak in clean water, change the water 1-2 times a day, if it is salty desert cistanche deserticola, soak all the salt, moisten thoroughly, slice longitudinally, and dry in the sun;
19、虎杖:采得后,细锉,晒干; 19. Polygonum cuspidatum: after harvesting, file and dry in the sun;
20、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干; 20. Phellodendron: remove impurities, wash with water, remove, moisten thoroughly, slice or shred, and dry in the sun;
21、菟丝子:过箩去净杂质,洗净,晒干; 21. Cuscuta: Go through a basket to remove impurities, wash and dry;
22、乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出切片,筛去灰屑; 22. Black medicine: pick out impurities, separate the big and small pieces, soak them thoroughly with water, pay attention to changing the water according to the season to prevent stink, remove the slices in time, and sift out the dust;
23、制何首乌:取净何首乌片,置非铁质容器内,加黑豆及适量水同煮3—4小时,闷一夜,至外表黑色、内部褐色时,取出,去豆渣,晒至半干,将余液拌入,润透,切厚片,干燥; 23. Preparation of Polygonum multiflorum: Take clean Polygonum multiflorum slices, put them in a non-iron container, add black beans and appropriate amount of water and cook for 3-4 hours, keep it overnight, until the appearance is black and the interior is brown, take it out, remove the bean dregs, and dry in the sun until half dry. Stir the remaining liquid, moisten thoroughly, cut into thick slices, and dry;
24、山楂:拣净杂质,筛去核; 24. Hawthorn: pick out the impurities, sieve and remove the core;
25、鸡内金:拣去杂质,漂净晒干; 25. Chicken gold: pick out impurities, rinse and dry in the sun;
26、佛手柑:拣去杂质,用水喷润后,切碎,晒干; 26. Bergamot: remove impurities, spray with water, chop and dry;
27、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; 27. Salvia miltiorrhiza: pick out impurities, remove rhizomes, wash, remove, moisten, slice, and dry;
28、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干; 28. Moutan bark: remove impurities, remove wood core, wash, moisten, slice, and dry;
29、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; 29. Licorice: remove impurities, wash, soak in water until 80% transparent, remove, moisten, slice, and dry;
30、桑椹:用水洗净,拣去杂质,摘除长柄,晒干; 30. Mulberry: wash with water, remove impurities, remove the long handle, and dry in the sun;
31、黑芝麻:取原药材,除去杂质,筛去碎屑; 31. Black sesame: take raw medicinal materials, remove impurities, and sieve to remove debris;
32、紫河车:用新鲜的紫河车,横直割开血管,用水反复洗漂干净。 32. Ziheche: Use fresh Ziheche, cut the blood vessels horizontally and straightly, wash and rinse them with water repeatedly.
二、制备 2. Preparation
1、将所述重量的麦冬、白芷、生地黄、墨旱莲、当归、白芍、红花、补骨脂、女贞子、黄芪、大枣、侧柏叶、桑叶、玄参、党参、阿胶、龙眼肉、肉苁蓉、虎杖、黄柏、菟丝子、乌药、制首乌、山楂、鸡内金、佛手柑、丹参、牡丹皮、甘草、桑椹、黑芝麻、紫河车加水煎煮两次,第一次加水6倍量,武火煎煮沸腾10分钟,再用文火煎煮25分钟,过滤得第一次煎煮液。 1. Put the weight of Ophiopogon japonicus, Angelica dahurica, Rehmannia glutinosa, Eclipta chinensis, Angelica sinensis, Radix Paeoniae Alba, Safflower, Psoralen, Ligustrum lucidum, Astragalus, Jujube, Arborvitae leaves, mulberry leaves, Scrophulariaceae, Dangshen, donkey-hide gelatin, longan meat, Cistanche, Polygonum cuspidatum, Cortex Phellodendri, Cuscuta, Wuyao, Zhishouwu, Hawthorn, Gallus gallus, Bergamot, Salvia, Moutan bark, licorice, mulberry, black sesame, Ziheche, add water and boil for two The first time, add 6 times the amount of water for the first time, decoct with strong fire for 10 minutes, then decoct with slow fire for 25 minutes, and filter to obtain the decoction for the first time.
2、将第一次过滤后的药渣加水4倍量,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第二次煎煮液。 2. Add 4 times the amount of water to the dregs filtered for the first time, decoct with strong fire to boil, then decoct with slow fire for 20 minutes, and filter to obtain the second decoction liquid.
3、合并两次煎煮液,武火煮沸,再用文火煎煮10分钟,分为4剂服用。 3. Combine the two decoction liquids, boil with high fire, then decoct with slow fire for 10 minutes, divide into 4 doses and take.
本发明药物具有补肾益阴、养血柔肝的功能,用于治疗小儿脱发见效快、疗效好。以下通过试验例来进一步阐述本发明药物的有益效果,这些试验包括本发明药物的动物毒性试验和临床疗效观察试验。 The medicine of the invention has the functions of invigorating the kidney and benefiting yin, nourishing blood and softening the liver, and is used for treating hair loss in children with quick effect and good curative effect. The beneficial effects of the medicament of the present invention are further described below through test examples, and these tests include animal toxicity tests and clinical curative effect observation tests of the medicament of the present invention.
[试验例1]本发明药物的动物毒性试验 [Test example 1] animal toxicity test of medicine of the present invention
取西德兔30只,雌雄兼用,体重2.0-2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超剂量试验组为25ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天二次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。 Take 30 West German rabbits, both male and female, weighing 2.0-2.5kg, and divide them into two groups, 15 rabbits in each group, one of which is the overdose test group, and the other is the normal dose test group. The overdose test group was 25ml/kg, and the normal amount was 10ml/kg. The administration method was administered by intragastric administration, twice a day, and served for 7 days. The administration reaction was observed every day. Normal, the drug has no adverse side effects.
[试验例2]本发明药物的临床疗效观察 [Test example 2] clinical curative effect observation of medicine of the present invention
1、一般资料 1. General information
收治门诊3-12岁患者共100例。 A total of 100 outpatients aged 3-12 were admitted to the clinic.
2、诊断标准 2. Diagnostic criteria
儿童掉头发的原因有很多,每种情况都有其不同的症状,包括: There are many causes of hair loss in children, and each condition has its own different symptoms, including:
(1)头上发秃的地方一块一块的,颜色发红,容易掉皮(有时候,掉头发的地方是黑色的),这说明宝宝可能长了头癣,这种传染性真菌感染是儿童掉头发最常见的原因。 (1) The bald places on the head are patchy, red in color, and easy to peel off (sometimes, the place where the hair is lost is black), which means that the baby may have tinea capitis, which is an infectious fungal infection in children. The most common cause of hair loss.
(2)生理损伤。比如小女孩因扎马尾辫或梳辫子的地方太紧或烫染发,导致牵拉性脱发。 (2) Physiological damage. For example, a little girl has traction alopecia due to tight ponytails or braids or hot dyed hair.
(3)小孩总爱情不自禁地绕头发或拔头发,可能会导致头发不规则地一块一块脱落,这叫做“拔毛发癖”。 (3) Children always love to twist or pull their hair involuntarily, which may cause the hair to fall off irregularly one by one, which is called "trichotillomania".
(4)小孩脱发的地方又圆又光,一根头发都没有,那可能是斑秃,说明孩子的免疫系统攻击了毛囊,彻底减缓了头发的生长速度。虽然这种类型的脱发通常都是在某一局部出现,但也可能会影响到全身的毛发。 (4) The child's hair loss area is round and smooth, and there is no hair at all. It may be alopecia areata, which means that the child's immune system has attacked the hair follicles and completely slowed down the growth rate of hair. While this type of hair loss is usually localized, it can also affect hair all over the body.
(5)某些疾病,比如甲状腺机能减退(即甲状腺紊乱)或者垂体机能减退(即垂体腺不够活跃),也会导致孩子头上各处头发脱落。 (5) Certain diseases, such as hypothyroidism (i.e., a disorder of the thyroid gland) or hypopituitarism (i.e., the pituitary gland is not active enough), can also cause hair loss in various places on the child's head.
3、治疗方法 3. Treatment method
选用上述药剂,给患者服用,3-4岁每次1/3剂,5-8岁每次1/2剂,9-12岁每次1剂,早晚各一次,30天为一个疗程,连续服用4个疗程。 Choose the above medicines and give them to patients, 1/3 dose each time for 3-4 years old, 1/2 dose each time for 5-8 years old, 1 dose each time for 9-12 years old, once in the morning and evening, 30 days as a course of treatment, continuous Take 4 courses of treatment.
4、疗效评定标准 4. Evaluating Criteria for Efficacy
显效:小儿脱发症状痊愈,恢复正常。 Significantly effective: the children's hair loss symptoms recovered and returned to normal.
好转:小儿脱发症状减轻,逐步好转。 Improvement: the children's hair loss symptoms were relieved and gradually improved.
无效:达不到好转标准者。 Invalid: Those who fail to meet the improvement standard.
5、治疗结果(见下表): 5. Treatment results (see the table below):
在上述治疗中,用本发明药物治疗小儿脱发患者100例,结果显效81例,显效率为81%,好转8例,好转率为8%,无效11例,总有效率为89%。 In the above-mentioned treatment, 100 cases of children with alopecia were treated with the medicine of the present invention, and 81 cases were markedly effective, and the effective rate was 81%, 8 cases took a turn for the better, and the rate of improvement was 8%, 11 cases were invalid, and the total effective rate was 89%.
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