CN103735447B - A kind of antiperspirant composition - Google Patents
A kind of antiperspirant composition Download PDFInfo
- Publication number
- CN103735447B CN103735447B CN201310705353.7A CN201310705353A CN103735447B CN 103735447 B CN103735447 B CN 103735447B CN 201310705353 A CN201310705353 A CN 201310705353A CN 103735447 B CN103735447 B CN 103735447B
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- CN
- China
- Prior art keywords
- antiperspirant composition
- polypropylene glycol
- schlz
- solms
- smith
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 21
- 230000001166 anti-perspirative effect Effects 0.000 title claims abstract description 20
- 239000003213 antiperspirant Substances 0.000 title claims abstract description 20
- 241000160052 Solms-laubachia linearifolia Species 0.000 claims abstract description 12
- 241000466346 Neoalsomitra integrifoliola Species 0.000 claims abstract description 11
- 229920001451 polypropylene glycol Polymers 0.000 claims abstract description 10
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 5
- BTFJIXJJCSYFAL-UHFFFAOYSA-N icosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims abstract description 4
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 239000012567 medical material Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 5
- 239000012467 final product Substances 0.000 claims description 5
- 239000000155 melt Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 2
- 210000002683 foot Anatomy 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 210000000106 sweat gland Anatomy 0.000 description 5
- 239000003814 drug Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 241000075088 Pilocarpus jaborandi Species 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 241001233957 eudicotyledons Species 0.000 description 2
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical group C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 159000000013 aluminium salts Chemical class 0.000 description 1
- 229910000329 aluminium sulfate Inorganic materials 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000000879 optical micrograph Methods 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
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- Cosmetics (AREA)
Abstract
The present invention provides a kind of antiperspirant composition, by higher alcohol 15-30 part that carbon number is 12-26, is specially spermol, stearyl alcohol, arachidic alcohol；Containing polypropylene glycol 3-15 part that molecular weight is 400-2000；3-5 part Neoalsomitra integrifoliola (Cogn.) Hucth. and 6-8 part Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz. composition, and have employed corresponding preparation method, this antiperspirant composition has effect of hidroschesis。
Description
Technical field
The present invention relates to cosmetic technical field, be specifically related to a kind of antiperspirant composition。
Background technology
Antiperspirant is widely used, and generally combines aluminium salt, bores salt, higher alcohol, Y 7175 etc.。But, such antiperspirant can not reach to meet the level of use sense, attempts improving antiperspirant deodorant effect and improving use sense。But, it is also desirable that there is more excellent antiperspirant composition, in particular with Chinese medicine。
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of antiperspirant composition and preparation method thereof。
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of antiperspirant composition, is made up of following component (A), (B) and (C):
(A) carbon number is higher alcohol 15-30 part of 12-26, is specially spermol, stearyl alcohol, arachidic alcohol；
(B) mean molecule quantity is polypropylene glycol 3-15 part of 400-2000；
(C) 3-5 part Neoalsomitra integrifoliola (Cogn.) Hucth. and 6-8 part Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz.。
Above-mentioned antiperspirant composition, preparation method is: take Neoalsomitra integrifoliola (Cogn.) Hucth. and Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz., boiling twice, add water 8-12 times amount into medical material weight for the first time, decocts 1-2h, add water 6-10 times amount into medical material weight for the second time, decocting 1-2h collecting decoction, being concentrated into relative density when 65 DEG C is 1.10-1.20, adds) carbon number is the higher alcohol of 12-26 and mean molecule quantity is the polypropylene glycol of 400-2000, about 70-80 DEG C melt and dissolved, to obtain final product。
Above-mentioned antiperspirant composition, component (B) is mean molecule quantity is the polypropylene glycol of 400-1000。
The application in preparing antiperspirant composition of the above-mentioned antiperspirant composition。
Beneficial effect: Neoalsomitra integrifoliola (Cogn.) Hucth. removing pathogenic heat from blood and toxic substance from the body in the present invention, convergence pain relieving, heat clearing and inflammation relieving, Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz. hemostasia and detumescence, reunion of fractured tendons and bones, vigorate qi and replenish the blood, both compatibilities prepare into antiperspirant composition antiperspirancy performance。
Test one, the present invention impact on rat paw portion sweat secretion
1, instrument and reagent antiperspirant composition of the present invention: prepare by embodiment 3 method, rat oral gavage device, syringe, syringe needle, timing clock, tool plug vial (50m1), guillotine。Pilocarpus jaborandi aqueous slkali 1mg/ml, 10% formalin。
2, experimental animal Wistar rat, body weight 200 ± 20g, male and female dual-purpose, cleaning grade。Thered is provided by Shanghai Slac Experimental Animal Co., Ltd., production licence: SCXK (Shanghai) 2007-0005。
3, rat 20, weigh numbering, it is randomly divided into two groups, respectively pilocarpine group and of the present invention group, Pilocarpus jaborandi aqueous slkali and the present invention is smeared respectively in foot sole of the foot portion, it is administered latter 2 hours, 4th group is blocked pair hind leg in latter 1 hour neat ankle of administration is instantaneous, take off biped sole of the foot portion meat lift skin and each 2-3. block of subcutaneous tissue immediately, fix according to a conventional method, dehydration, embedding, section, HE dyes, optical microphotograph Microscopic observation respectively organizes the change in rat paw portion sweat gland epithelial cell, the incidence rate of main detection cavity, and carry out count ratio relatively, found that sweat gland is had certain inhibitory action by the present invention。
The present invention is to the rat biped sole of the foot portion morphologic shadow noon (χ ± s, n=10) of sweat gland epithelial cell
Note: compare with model group*p<0.05**<0.01
Cavity generation percentage rate=(cavity sweat gland number/observation sweat gland number) x100%
Detailed description of the invention
Form by the following examples, the foregoing of the present invention is described in further detail again, but this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to Examples below, and all technology realized based on foregoing of the present invention belong to the scope of the present invention。
Embodiment 1
Take Neoalsomitra integrifoliola (Cogn.) Hucth. 3 parts and Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz. 6 parts, boiling twice, add water 8 times amount into medical material weight for the first time, decocts 1h, add water 6 times amount into medical material weight for the second time, decocting 1h collecting decoction, being concentrated into relative density when 65 DEG C is 1.10, adds spermol 15 parts, molecular weight is the polypropylene glycol 3 parts of 400, heating and melting, mix homogeneously, to obtain final product。
Embodiment 2
Take Neoalsomitra integrifoliola (Cogn.) Hucth. 4 parts and Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz. 7 parts, boiling twice, add water 10 times amount into medical material weight for the first time, decocts 1.5h, add water 8 times amount into medical material weight for the second time, decocting 1.5h collecting decoction, being concentrated into relative density when 65 DEG C is 1.15, adds arachidic alcohol 30 parts, molecular weight is the polypropylene glycol 15 parts of 2000, heating and melting, mix homogeneously, to obtain final product。
Embodiment 3
Take Neoalsomitra integrifoliola (Cogn.) Hucth. 5 parts and Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz. 8 parts, boiling twice, add water 12 times amount into medical material weight for the first time, decocts 2h, add water 10 times amount into medical material weight for the second time, decocting 2h collecting decoction, being concentrated into relative density when 65 DEG C is 1.2, adds stearyl alcohol 25 parts, molecular weight is the polypropylene glycol 8 parts of 1000, heating and melting, mix homogeneously, to obtain final product。
Above-mentioned Neoalsomitra integrifoliola (Cogn.) Hucth. is the tuber that dicotyledon medicine cucurbitaceous plant fund is firm, Classification system: Neoalsomitraintegrifoliola (Cogn.) Hutch., Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz. is the herb of dicotyledon medicine crucifer Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz., latin name: Solms-LaubachiaLinearifolia (W.W.Smith) O.E.Schlz.。
Claims (2)
1. an antiperspirant composition, it is characterised in that be made up of following component (A), (B) and (C):
(A) carbon number is higher alcohol 15-30 part of 12-26, for spermol, stearyl alcohol, arachidic alcohol；
(B) mean molecule quantity is polypropylene glycol 3-15 part of 400-2000；
(C) 3-5 part Neoalsomitra integrifoliola (Cogn.) Hucth. and 6-8 part Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz., the preparation method of described antiperspirant composition is: take Neoalsomitra integrifoliola (Cogn.) Hucth. and Solms-Laubachia Linearifolia (W. W. Smith) O. E. Schlz., boiling twice, and add water 8-12 times amount into medical material weight for the first time, decoct 1-2h, add water 6-10 times amount into medical material weight for the second time, decocts 1-2h, collecting decoction, being concentrated into relative density when 65 DEG C is 1.10-1.20, adding carbon number and be the higher alcohol of 12-26 and mean molecule quantity is the polypropylene glycol of 400-2000,70-80 DEG C melts, to obtain final product。
2. antiperspirant composition as claimed in claim 1, it is characterised in that component (B) is mean molecule quantity is the polypropylene glycol of 400-1000。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310705353.7A CN103735447B (en) | 2013-12-20 | 2013-12-20 | A kind of antiperspirant composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310705353.7A CN103735447B (en) | 2013-12-20 | 2013-12-20 | A kind of antiperspirant composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103735447A CN103735447A (en) | 2014-04-23 |
| CN103735447B true CN103735447B (en) | 2016-06-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310705353.7A Expired - Fee Related CN103735447B (en) | 2013-12-20 | 2013-12-20 | A kind of antiperspirant composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103735447B (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0525395D0 (en) * | 2005-10-28 | 2006-01-18 | Unilever Plc | Antiperspirant or deodorant compositions |
| US20070253922A1 (en) * | 2006-04-28 | 2007-11-01 | Kao Corporation | Anhydrous antiperspirant/deodorant stick compositions |
| DE102011089340A1 (en) * | 2011-12-21 | 2013-06-27 | Henkel Ag & Co. Kgaa | PEG-free antiperspirant oil-in-water emulsions with improved feel |
| CN102836111B (en) * | 2012-09-20 | 2013-10-16 | 谢玲艳 | Antisudorific compound |
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2013
- 2013-12-20 CN CN201310705353.7A patent/CN103735447B/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN103735447A (en) | 2014-04-23 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Gao Yanping Inventor before: Li Qiang |
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| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160527 Address after: 273300 No. 235 Lianhua Road, Pingyi County, Shandong Province Applicant after: Gao Yanping Address before: 266000 Shandong province Qingdao City Red Road No. 31 North Building 201 Applicant before: Li Qiang |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160622 Termination date: 20161220 |