CN103705388A - Fullerene capsule and application thereof - Google Patents
Fullerene capsule and application thereof Download PDFInfo
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- CN103705388A CN103705388A CN201310701775.7A CN201310701775A CN103705388A CN 103705388 A CN103705388 A CN 103705388A CN 201310701775 A CN201310701775 A CN 201310701775A CN 103705388 A CN103705388 A CN 103705388A
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- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 title claims abstract description 89
- 229910003472 fullerene Inorganic materials 0.000 title claims abstract description 85
- 239000002775 capsule Substances 0.000 title claims abstract description 76
- 239000000463 material Substances 0.000 claims abstract description 28
- 239000002537 cosmetic Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 235000013305 food Nutrition 0.000 claims description 4
- 238000005538 encapsulation Methods 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 230000007774 longterm Effects 0.000 abstract description 10
- 230000005540 biological transmission Effects 0.000 abstract description 5
- 230000006866 deterioration Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 239000013543 active substance Substances 0.000 abstract description 3
- 238000007789 sealing Methods 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 11
- 239000004006 olive oil Substances 0.000 description 8
- 238000004806 packaging method and process Methods 0.000 description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 6
- 229920001661 Chitosan Polymers 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 229940032094 squalane Drugs 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
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- 239000002131 composite material Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000007760 free radical scavenging Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 238000000844 transformation Methods 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241001342895 Chorus Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000238367 Mya arenaria Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
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- 231100000160 chronic toxicity Toxicity 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- HAORKNGNJCEJBX-UHFFFAOYSA-N cyprodinil Chemical compound N=1C(C)=CC(C2CC2)=NC=1NC1=CC=CC=C1 HAORKNGNJCEJBX-UHFFFAOYSA-N 0.000 description 1
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- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 210000002784 stomach Anatomy 0.000 description 1
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Abstract
本发明公开一种富勒烯胶囊及其应用，其中，富勒烯胶囊包括：作为活性成分的功能化富勒烯材料和封装所述功能化富勒烯材料的胶囊外壳。本发明解决了功能化富勒烯材料在实际的使用过程中添加量有限，可能造成大包装多次使用带来的二次污染，以及长期储存造成的产品变质问题；并且胶囊产品一般一个胶囊或多个胶囊为一次用量，因此避免了多次使用的污染问题；胶囊产品密封性好，透光性差，因此更利于某些怕光产品的长期保存，提高了产品的保质期；将功能化富勒烯制作成胶囊，且每个胶囊中活性物质的含量一定，更有利于使用者定量服用。The invention discloses a fullerene capsule and an application thereof, wherein the fullerene capsule comprises: a functionalized fullerene material as an active ingredient and a capsule shell encapsulating the functionalized fullerene material. The present invention solves the problems of limited addition of functionalized fullerene materials in the actual use process, which may cause secondary pollution caused by repeated use of large packages, and product deterioration caused by long-term storage; and capsule products are generally a capsule or Multiple capsules are used at one time, so the pollution problem of repeated use is avoided; the capsule product has good sealing performance and poor light transmission, so it is more conducive to the long-term storage of some light-sensitive products and improves the shelf life of the product; the functionalized Fuller It is made into capsules, and the content of active substances in each capsule is constant, which is more conducive to users to take it quantitatively.
Description
技术领域 technical field
本发明涉及富勒烯功能材料领域，尤其涉及一种富勒烯胶囊及其应用。 The invention relates to the field of fullerene functional materials, in particular to a fullerene capsule and an application thereof.
背景技术 Background technique
富勒烯是由碳元素组成的以球状或类椭圆状结构存在的一类物质，它与金刚石和石墨同为碳的同素异形体。经过多年研究发现，富勒烯具有多重优异的性能，在生物，医药，光学，磁学，能源等领域都有着不俗的表现。其中富勒烯优异的自由基清除性能引起了科学家的极大关注，同时一系列基于生物应用的功能化富勒烯分子被合成。目前，针对功能化富勒烯的应用，一是利用富勒烯高效清除自由基的性能，将功能化富勒烯应用到化妆品市场，市场上已有多款添加有功能化富勒烯的化妆品，例如日本DHC，台湾shinningway（萱薇），台湾chorus（卡若丝），台湾森田药妆，台湾DR.WU，韩国missha，香港Joserestine等公司。其次，在生物医学领域，也已经有相关研究小组和公司进行了详细试验和论证， 2011年法国Fathi Moussa研究小组发表在Biomaterials上的文章（Biomaterials 33 (2012) 4936e4946）公布了他们的重大发现：将C60分散到橄榄油后喂食小鼠，发现C60没有慢性毒性，可以使得小鼠的寿命延长两年之久，预示着C60有可能在治疗癌症，神经退行性疾病以及机体老化等疾病方面得到应用；经研究证明富勒烯保健水还可以在改善疲劳，增进食欲，缓解便秘，调理肠胃，缓解关节疼痛等方面的功效，实际上C60-橄榄油以及富勒烯水同样具备优异的自由基清除性能，因此也可以作为外用物应用到化妆品领域。 Fullerene is a class of substances composed of carbon elements that exist in a spherical or oval-like structure. It is the same allotrope of carbon as diamond and graphite. After years of research, it has been found that fullerene has multiple excellent properties, and it has a good performance in the fields of biology, medicine, optics, magnetism, energy and so on. Among them, the excellent free radical scavenging performance of fullerene has attracted great attention of scientists, and a series of functionalized fullerene molecules based on biological applications have been synthesized. At present, for the application of functionalized fullerenes, one is to use the performance of fullerenes to efficiently scavenge free radicals, and to apply functionalized fullerenes to the cosmetics market. There are many cosmetics with functionalized fullerenes on the market. , such as Japan DHC, Taiwan shinningway (Xuanwei), Taiwan chorus (Caruosi), Taiwan Morita Cosmeceuticals, Taiwan DR.WU, Korea missha, Hong Kong Joserestine and other companies. Secondly, in the field of biomedicine, relevant research groups and companies have conducted detailed experiments and demonstrations. In 2011, the French Fathi Moussa research group published an article on Biomaterials (Biomaterials 33 (2012) 4936e4946) published their major findings: After dispersing C 60 in olive oil and feeding it to mice, it was found that C 60 has no chronic toxicity and can prolong the lifespan of mice by two years, which indicates that C 60 may be effective in treating diseases such as cancer, neurodegenerative diseases and body aging It has been applied in various aspects; it has been proved by research that fullerene health water can also improve fatigue, increase appetite, relieve constipation, regulate the stomach, and relieve joint pain. In fact, C 60 -olive oil and fullerene water also have excellent Free radical scavenging performance, so it can also be used as an external application in the field of cosmetics.
功能化富勒烯的性能优异，因此在实际化妆品中的添加量并不是很大，即便是作为保健品使用，一次用量也是较少的，但是由于目前市售商品均为大包装，因此就存在多次使用可能造成的二次污染问题，以及长期储存可能会造成的产品变质问题等等。目前功能化富勒烯产品还仅限于中高端的大型化妆品公司，在保健领域也还没有广泛应用，功能化富勒烯的使用方式还没有普及到个人消费行为。同时，市售功能化富勒烯产品包装规格较大，尤其一些水溶性富勒烯产品，如C60-聚乙烯吡咯烷酮，由于是以水溶液的状态储存，久置存在溶剂水挥发而导致产品浓度变化的问题，这样就影响了使用的方便性，这是因为一般功能化富勒烯产品都有使用的复配比例指导，如果产品浓度变化后，已有的复配比例指导就不再适用了；另外，例如，富勒醇这样的功能化富勒烯需要避光低温保存，因此大包装更不适合长期使用。 Functionalized fullerene has excellent performance, so the amount added in actual cosmetics is not very large. Even if it is used as a health care product, the amount of one-time use is relatively small. However, since the current commercial products are all in large packages, there are Secondary pollution problems that may be caused by repeated use, and product deterioration problems that may be caused by long-term storage, etc. At present, functionalized fullerene products are limited to medium and high-end large cosmetic companies, and have not been widely used in the field of health care. The use of functionalized fullerenes has not yet spread to personal consumption behavior. At the same time, commercially available functionalized fullerene products have larger packaging specifications, especially some water-soluble fullerene products, such as C 60 -polyvinylpyrrolidone, because they are stored in the state of aqueous solution, the solvent water volatilizes after long-term storage, resulting in product concentration The problem of changing, which affects the convenience of use, is because the general functionalized fullerene products have a compounding ratio guide for use. If the product concentration changes, the existing compounding ratio guide is no longer applicable ; In addition, for example, functionalized fullerenes such as fullerenes need to be kept away from light and low temperature, so large packages are not suitable for long-term use.
因此，现有技术还有待于改进和发展。 Therefore, the prior art still needs to be improved and developed.
发明内容 Contents of the invention
鉴于上述现有技术的不足，本发明的目的在于提供一种富勒烯胶囊及其应用，旨在解决现有的富勒烯包装方式容易造成二次污染、易变质的问题。 In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a fullerene capsule and its application, aiming at solving the problem that the existing fullerene packaging method is easy to cause secondary pollution and easy to deteriorate.
本发明的技术方案如下： Technical scheme of the present invention is as follows:
一种富勒烯胶囊，其中，包括：作为活性成分的功能化富勒烯材料和封装所述功能化富勒烯材料的胶囊外壳。 A fullerene capsule, comprising: a functionalized fullerene material as an active ingredient and a capsule shell encapsulating the functionalized fullerene material.
所述的富勒烯胶囊，其中，所述功能化富勒烯材料为富勒烯-高分子材料复合物。 The fullerene capsule, wherein the functionalized fullerene material is a fullerene-polymer material composite.
所述的富勒烯胶囊，其中，所述功能化富勒烯材料为富勒烯衍生物。 The fullerene capsule, wherein the functionalized fullerene material is a fullerene derivative.
所述的富勒烯胶囊，其中，所述功能化富勒烯材料为富勒烯油溶液或富勒烯水溶性簇。 The fullerene capsule, wherein the functionalized fullerene material is a fullerene oil solution or a water-soluble fullerene cluster.
所述的富勒烯胶囊，其中，所述功能化富勒烯材料为粉末或溶液。 The fullerene capsule, wherein the functionalized fullerene material is powder or solution.
所述的富勒烯胶囊，其中，所述胶囊外壳为硬外壳，或者软外壳。 The fullerene capsule, wherein, the capsule shell is a hard shell or a soft shell.
所述的富勒烯胶囊，其中，胶囊外壳中的功能化富勒烯材料的包装规格为1000mg。 The fullerene capsule, wherein the packaging specification of the functionalized fullerene material in the capsule shell is 1000mg.
一种如上所述的富勒烯胶囊的应用，其中，将所述富勒烯胶囊应用于化妆品或食物中使用。 An application of the fullerene capsule as described above, wherein the fullerene capsule is used in cosmetics or food.
有益效果：本发明解决了功能化富勒烯材料在实际的使用过程中添加量有限，可能造成大包装多次使用带来的二次污染，以及长期储存造成的产品变质问题；并且胶囊产品一般一个胶囊或多个胶囊为一次用量，因此避免了多次使用的污染问题；胶囊产品密封性好，透光性差，因此更利于某些怕光产品的长期保存，提高了产品的保质期；将功能化富勒烯制作成胶囊，且每个胶囊中活性物质的含量一定，更有利于使用者定量服用。 Beneficial effects: the present invention solves the problems of limited addition of functionalized fullerene materials in the actual use process, which may cause secondary pollution caused by repeated use of large packages, and product deterioration caused by long-term storage; and capsule products are generally One capsule or multiple capsules are used at one time, so the pollution problem of repeated use is avoided; the capsule product has good sealing performance and poor light transmission, so it is more conducive to the long-term storage of some light-sensitive products and improves the shelf life of the product; Fullerenes are made into capsules, and the content of active substances in each capsule is certain, which is more beneficial for users to take quantitatively.
具体实施方式 Detailed ways
本发明提供一种富勒烯胶囊及其应用，为使本发明的目的、技术方案及效果更加清楚、明确，以下对本发明进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。 The present invention provides a fullerene capsule and its application. In order to make the purpose, technical solution and effect of the present invention clearer and clearer, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
本发明所提供的一种富勒烯胶囊，其包括：作为活性成分的功能化富勒烯材料和封装所述功能化富勒烯材料的胶囊外壳。通过将功能化富勒烯材料封装入胶囊中，每个胶囊均为一次用量，避免了大包装多次使用带来的二次污染，以及长期储存造成的产品变质问题；并且在化妆品领域，胶囊形式的产品来对富勒烯材料进行包装，将会更容易被接受。 A fullerene capsule provided by the present invention comprises: a functionalized fullerene material as an active ingredient and a capsule shell encapsulating the functionalized fullerene material. By encapsulating functionalized fullerene materials into capsules, each capsule is used once, avoiding secondary pollution caused by repeated use of large packages, and product deterioration caused by long-term storage; and in the field of cosmetics, capsules Packaging fullerene materials in the form of products will be more acceptable.
本发明中的功能化富勒烯材料可以为，富勒烯-高分子材料复合物，例如，C60-聚乙烯吡咯烷酮，C60-壳聚糖，C60-聚乙二醇等；也可以为富勒烯衍生物，例如，富勒醇C60(OH)n，富勒酸C60(CH2COOH) n等；可以为富勒烯油溶液，例如C60-角鲨烷，C60-橄榄油等；可以为富勒烯水溶性簇，例如富勒烯水等。 The functionalized fullerene material in the present invention can be a fullerene-polymer material composite, for example, C 60 -polyvinylpyrrolidone, C 60 -chitosan, C 60 -polyethylene glycol, etc.; For fullerene derivatives, for example, fullerene alcohol C 60 (OH) n , fulleric acid C 60 (CH 2 COOH) n etc.; can be fullerene oil solution, for example C 60 -squalane, C 60 - olive oil, etc.; may be fullerene water-soluble clusters, such as fullerene water, etc.
并且，本发明中，胶囊中的功能化富勒烯材料其存在形式可以为溶液状态，例如C60-角鲨烷或C60-橄榄油；也可以是固体粉末状态，例如C60-聚乙烯吡咯烷酮、C60-壳聚糖、C60-聚乙二醇、富勒烯水、富勒醇C60 (OH) n或富勒酸C60 (CH2COOH) n，固体粉末可以是低温低压干燥得到，也可以是常温低压干燥得到，也可以是通过喷雾干燥方式得到。 Moreover, in the present invention, the functionalized fullerene material in the capsule can exist in a solution state, such as C 60 -squalane or C 60 -olive oil; it can also be in a solid powder state, such as C 60 -polyethylene Pyrrolidone, C 60 -chitosan, C 60 - polyethylene glycol, fullerene water, fullerenol C 60 (OH) n or fulleric acid C 60 (CH 2 COOH) n , solid powder can be low temperature and low pressure It can be obtained by drying, which can also be obtained by drying at normal temperature and low pressure, or by spray drying.
同时，本发明中的胶囊外壳可以是硬外壳，也可以是软胶囊外壳，胶囊外壳的透光性可以根据具体功能化富勒烯材料的物理化学性质而定，较优选的是，选择透光性差的胶囊外壳，避免光线对内容物的影响，例如对于富勒醇产品，选择透光性差的胶囊外壳，可以更好长期保存，延长使用寿命。 At the same time, the capsule shell in the present invention can be a hard shell or a soft capsule shell. The light transmission of the capsule shell can be determined according to the physical and chemical properties of the specific functionalized fullerene material. More preferably, the light transmission Capsule shells with poor light transmittance can avoid the influence of light on the contents. For example, for fullerol products, choose capsule shells with poor light transmittance, which can better store for a long time and prolong the service life.
在本发明中，胶囊外壳中的功能化富勒烯材料的包装规格优选为1000mg，当然，可根据实际需要选择其他形式的包装规格。 In the present invention, the packaging specification of the functionalized fullerene material in the capsule shell is preferably 1000 mg, of course, other packaging specifications can be selected according to actual needs.
本发明解决了功能化富勒烯材料在实际的使用过程中添加量有限，可能造成大包装多次使用带来的二次污染，以及长期储存造成的产品变质问题；并且胶囊产品一般一个胶囊或多个胶囊为一次用量，因此避免了多次使用的污染问题；胶囊产品密封性好，透光性差，因此更利于某些怕光产品的长期保存，提高了产品的保质期；将功能化富勒烯制作成胶囊，且每个胶囊中活性物质的含量一定，更有利于使用者定量服用。 The present invention solves the problems of limited addition of functionalized fullerene materials in the actual use process, which may cause secondary pollution caused by repeated use of large packages, and product deterioration caused by long-term storage; and capsule products are generally a capsule or Multiple capsules are used at one time, so the pollution problem of repeated use is avoided; the capsule product has good sealing performance and poor light transmission, so it is more conducive to the long-term storage of some light-sensitive products and improves the shelf life of the product; the functionalized Fuller It is made into capsules, and the content of active substances in each capsule is constant, which is more conducive to users to take it quantitatively.
实施例一 Embodiment one
将C60-聚乙烯吡咯烷酮溶液低温低压干燥成粉末，然后封装入胶囊中，每粒含C60-聚乙烯吡咯烷酮1000mg，封口即得C60-聚乙烯吡咯烷酮胶囊。 The C 60 -polyvinylpyrrolidone solution is dried at low temperature and low pressure into powder, and then encapsulated into capsules, each containing 1000 mg of C 60 -polyvinylpyrrolidone, and sealed to obtain C 60 -polyvinylpyrrolidone capsules.
实施例二 Embodiment two
将C60-壳聚糖溶液低温低压干燥成粉末，然后封装入胶囊中，每粒含C60-壳聚糖1000mg，封口即得C60-壳聚糖胶囊。 The C 60 -chitosan solution is dried at low temperature and low pressure into powder, and then encapsulated into capsules, each containing 1000 mg of C 60 -chitosan, and sealed to obtain the C 60 -chitosan capsule.
实施例三 Embodiment three
将C60-聚乙二醇溶液低温低压干燥成粉末，然后封装入胶囊中，每粒含C60-聚乙二醇1000mg，封口即得C60-聚乙二醇胶囊。 The C 60 -polyethylene glycol solution is dried under low temperature and low pressure into powder, and then encapsulated into capsules, each containing 1000 mg of C 60 -polyethylene glycol, and sealed to obtain C 60 -polyethylene glycol capsules.
实施例四 Embodiment four
将富勒烯水浓缩干燥成富勒烯簇，然后封装入胶囊中，每粒含富勒烯簇1000mg，封口即得富勒烯簇胶囊。 Concentrate and dry fullerene water to form fullerene clusters, and then encapsulate them into capsules, each containing 1000 mg of fullerene clusters, and seal to obtain fullerene cluster capsules.
实施例五 Embodiment five
将C60-角鲨烷溶液封装入胶囊，每粒含C60-角鲨烷1000mg，封口即得C60-角鲨烷液体胶囊。 Seal the C 60 -squalane solution into capsules, each containing 1000 mg of C 60 -squalane, and seal the seal to obtain a C 60 -squalane liquid capsule.
实施例六 Embodiment six
将C60-橄榄油溶液封装入胶囊，每粒含C60-橄榄油1000mg，封口即得C60-橄榄油液体胶囊。 Seal the C 60 -olive oil solution into capsules, each containing 1000mg of C 60 -olive oil, and seal the seal to get C 60 -olive oil liquid capsules.
实施例七 Embodiment seven
取一粒C60-聚乙烯吡咯烷酮胶囊，将胶囊内容物倾倒入容器中，根据需要配置成一定浓度的溶液，然后向其中加入其它护肤成分，例如，维生素C，蜂蜜，牛奶等的混合物，调配成一次用量的护肤品，然后涂抹于脸部。 Take a C 60 -polyvinylpyrrolidone capsule, pour the contents of the capsule into a container, prepare a solution with a certain concentration as required, and then add other skin care ingredients, such as a mixture of vitamin C, honey, milk, etc., to prepare Make a single dose of skin care products and apply to the face.
实施例八 Embodiment eight
取一粒C60-橄榄油液体胶囊，将胶囊内容物1000mg与食物进行混匀，然后作为食用物备用。 Take one C 60 -olive oil liquid capsule, mix 1000mg of the capsule content with food, and then use it as food for later use.
应当理解的是，本发明的应用不限于上述的举例，对本领域普通技术人员来说，可以根据上述说明加以改进或变换，所有这些改进和变换都应属于本发明所附权利要求的保护范围。 It should be understood that the application of the present invention is not limited to the above examples, and those skilled in the art can make improvements or transformations according to the above descriptions, and all these improvements and transformations should belong to the protection scope of the appended claims of the present invention.
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| WO2019184419A1 (en) * | 2018-03-27 | 2019-10-03 | 厦门福慈生物科技有限公司 | Use of fullerene compound, fullerene microcapsule powder and preparation method and application thereof |
| CN110301483A (en) * | 2018-03-27 | 2019-10-08 | 厦门福慈生物科技有限公司 | The purposes of fullerene compound and fullerene microcapsule powder and its preparation method and application |
| CN111228306A (en) * | 2020-03-06 | 2020-06-05 | 厦门福纳新材料科技有限公司 | Application of fullerene and fullerene derivative in regulating intestinal flora |
| CN112956686A (en) * | 2021-03-17 | 2021-06-15 | 厦门福慈生物科技有限公司 | Bowel relaxing composition and preparation method thereof |
| US11471484B2 (en) | 2011-06-30 | 2022-10-18 | Fathi Moussa | Fullerene and its use to maintain good health and to prolong the expected lifespan of mammals |
| CN115317402A (en) * | 2022-07-05 | 2022-11-11 | 北京福纳康生物技术有限公司 | Water-soluble fullerene chitin complex and preparation method and application thereof |
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| US11471484B2 (en) | 2011-06-30 | 2022-10-18 | Fathi Moussa | Fullerene and its use to maintain good health and to prolong the expected lifespan of mammals |
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| CN110301483A (en) * | 2018-03-27 | 2019-10-08 | 厦门福慈生物科技有限公司 | The purposes of fullerene compound and fullerene microcapsule powder and its preparation method and application |
| CN115024365A (en) * | 2018-03-27 | 2022-09-09 | 厦门福慈生物科技有限公司 | Application of fullerene to preparation of fullerene microcapsule powder and preparation method |
| CN111228306A (en) * | 2020-03-06 | 2020-06-05 | 厦门福纳新材料科技有限公司 | Application of fullerene and fullerene derivative in regulating intestinal flora |
| CN112956686A (en) * | 2021-03-17 | 2021-06-15 | 厦门福慈生物科技有限公司 | Bowel relaxing composition and preparation method thereof |
| CN115317402A (en) * | 2022-07-05 | 2022-11-11 | 北京福纳康生物技术有限公司 | Water-soluble fullerene chitin complex and preparation method and application thereof |
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