CN103704697A - Turnip-fructus hippophae tablet and preparation method and applications thereof - Google Patents
Turnip-fructus hippophae tablet and preparation method and applications thereof Download PDFInfo
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- CN103704697A CN103704697A CN201310739632.5A CN201310739632A CN103704697A CN 103704697 A CN103704697 A CN 103704697A CN 201310739632 A CN201310739632 A CN 201310739632A CN 103704697 A CN103704697 A CN 103704697A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a turnip-fructus hippophae tablet and a preparation method and applications thereof. The turnip-fructus hippophae tablet mainly comprises ingredients including turnip powder and fructus hippophae extract at a mass ratio of (3-6):(5-9). The production technique comprises the steps of by taking turnip of BrassicarapaL. as an active ingredient, slicing, drying, grinding, sterilizing and the like to obtain turnip powder, extracting, drying, grinding and the like by taking fruits of HippophaerhamnoidesL.subsp.SinensisRousi. as an active ingredient to obtain the fructus hippophae extract, mixing the turnip powder and the fructus hippophae extract powder to prepare granules, tabletting and packaging to obtain the turnip-fructus hippophae tablet. The turnip-fructus hippophae tablet has the beneficial effects of being used for producing food, hypolipidemic health-care products and drugs, having the efficacy of treating hyperlipidemia and various atherosclerosis, being more obvious in efficacy compared with the single turnip tablet and the single fructus hippophae tablet, having no toxic and side effects, and being good in mouth feeling, low in cost, and convenient to produce.
Description
Technical field
The invention belongs to health food preparing technical field, be specifically related to a kind of technology of preparing of Yuan root hippophae rhamnoides patch.
Background technology
In China, along with living standards of the people improve, rhythm of life is accelerated, dietary structure is to high heat, high esterified development, add that work, life stress strengthen, amount of exercise reduces, the reasons such as environmental pollution, China's hyperlipidemia incidence of disease is in continuous lifting, follow aging population to accelerate, the cardiovascular and cerebrovascular disease ratios such as the atherosclerotic being caused by high fat of blood in the elderly's angiocardiopathy, coronary heart disease are increases trend year by year simultaneously.Prevent or reduce high fat of blood, atherosclerotic generation, people, except strengthening self health consciousness, make great efforts to form good habits and customs, take certain intervening measure just to seem very necessary.
Yuan root belongs to west region character resource, also cries turnip, and ancient name turnip has another name called turnip, Orychophragmus violaceus, root-mustard, circle dish head, circle root, assorted cold dishes, is spermatophyta, Dicotyledoneae, Cruciferae Btassica, 2 years raw herbaceous plant.A mutation for leaf mustard, also referred to as root-mustard.Tibetan people claims that turnip is " girl's agate ".Because taste is sweet clearly being rich in nutrition again, turnip is subject to liking of the Tibet common people deeply.Snowy region ancients notice the medical value of " girl's agate " for a long time.According to Tibetan medicine note, cut: Yuan root, its profile circle is like radish, and taste is sweet, and packing is high, has the various functions such as clearing heat and detoxicating, nourishing oxygenation, reducing blood lipid, and human body is had to certain health-care effect.Turnip nutritional labeling is very abundant, and root is containing brassin (Rapin); The fatty oily 33%-45% of seed, volatile oil approximately 0.16%; In plant, also contain Cobastab
1, ascorbic acid, carrotene, fat, inorganic salts, carbohydrate and protein.According to surveying and determination, 90.5 grams of every 100 grams of fresh turnip moisture contents, 1.4 grams, protein, 0.1 gram, fat, 6.3 grams, carbohydrate, 0.9 gram of dietary fiber, and containing amino acid and the vitamin of multiple needed by human body.Turnip also has very high medical value.Traditional Chinese medicine is thought: turnip taste is sweet, pungent, bitter, warm in nature, nontoxic.Enter stomach, liver, kidney three warps.There is appetite-stimulating indigestion-relieving, during lower gas is wide, relieving cough and reducing sputum, eliminating damp, detoxifying, the effect of gentle taste.Remarkable to disease effects such as treatment coldaccumulating abdominalgia, poor appetite, accumulation of food in the stomach and intes tine due to indigestion, jaundice, acute mastitis and skin furuncles.In < < dietetic materia medica > >, record: " lower gas, the subcutaneous ulcer of harnessing the Yellow River, diuresis, root cures mainly quenches one's thirst, and controls hot malicious wind swollen.Boil as custard and eat it the eleventh month of the lunar calendar as the marshland full of water weeds, the place food that can disappear, and lower gas, controls and coughs." modern medicine study shows, turnip has following multiple efficacies: 1. help digest; 2. prevent and treat colon cancer; 3. reducing blood lipid; 4. promote organism balance, anti-ageing.
Sea-buckthorn is Elaeangnaceae (Elaeagnaceae) Hippophne (HippophaeLinn) machaka or dungarunga, has another name called vinegar willow, acid thorn, black thorn, it is examined a day loud, high-pitched sound and examines (covering name), Dagri cloth (hide), Ji Han (Uygur's name).There is cough-relieving apophlegmatic, relieving dyspepsia, the effect of promoting blood circulation to remove blood stasis, for coughing with a lot of sputum, indigestion, dyspeptic abdominalgia, falls that to flutter the stasis of blood swollen, and hemostasis is through the disease such as closing.By going through version version from 1977, < < Chinese pharmacopoeia > > recorded ethnic group's medical materials traditionally used in certain regions such as the Ye Shi Mongols, Tibetan.China be in the world the earliest exploitation sea-buckthorn in medical country.The discovery of the sea-buckthorn property of medicine and clinical practice trace Tibet, China folk medicine.Tetra-of Tibetan medicine's monumental work < < doctor allusion quotation > > in eightth century of Christian era record sea-buckthorns have eliminate the phlegm, sharp lung, dampness elimination, strong cloudy, rise positive effect, the function that wherein more than 60 strengthening spleen and nourishing stomach of locating also to have described sea-buckthorn and the broken stasis of blood are stopped blooding.In the precious > > of the classic doctor's work of the Tang Dynasty Tibetan medicine < < month king medicine, describe " sea-buckthorn is cured ' Baconic ', reinforcement sun, the appetizing chest that relaxes, diet is tasty and refreshing, easily digestion ".In Tibetan medicine's allusion quotation < < Jingzhubencao > >, claim: " dissolving phlegm is turbid for sea-buckthorn profit lung cough-relieving; promoting blood circulation and removing blood stasis, sharp heart blood vessels ", also claim that " hippophae rhamnoides seed is containing trace oil, help blood of human body." sea-buckthorn is a kind of medicine food dual purpose plant that contains multivitamin, various trace elements, several amino acids and other bioactivator.The former Russian scholar research finds that the active component in fruit reaches kind more than 190, and the active component in oil has 106 kinds, and (wherein liposoluble vitamin is 6 kinds, 22 kinds, aliphatic acid, 42 kinds of lipids, 36 kinds of flavones and phenols), the reports such as Ma Juyun, sea-buckthorn contains hundreds of bioactivator, Thioctic Acid kind wherein, 12 kinds of organic acid and monosaccharides, 22 kinds of amino acid and acyl Ammonias, 7 kinds, aliphatic acid, 32 kinds of lipids, 30 kinds of phenols and flavonoids, 4 kinds, protein, 29 kinds of trace elements.Modern medicine study shows, sea-buckthorn has anti-arrhythmia cordis, and antianginal improves myocardial ischemia, regulates blood fat, suppresses thrombosis, strengthens immunologic function, anti-oxidant, and neuroprotective cell, promotes the pharmacological effect widely such as apoptosis at inhibition cancer cell growth.
Summary of the invention
The object of the invention is to propose a kind of mouthfeel good, and be beneficial to reduction high fat of blood, formula, manufacture craft and the purposes of antiatherogenic Yuan root hippophae rhamnoides patch.
In order to reach above-mentioned purpose of design, the technical solution used in the present invention is as follows:
A Yuan root hippophae rhamnoides patch, main component comprises Yuan root, hippophae rhamnoides, the mass ratio of described Yuan root, hippophae rhamnoides is 3-6:5-9.
A manufacture craft for described Yuan root hippophae rhamnoides patch, comprises the following steps:
(1) feeding: get qualified Yuan root, sea buckthorn fruit;
(2) Yuan undercut sheet and dry: Yuan root is cut into slices with machine for traditional Chinese medicinal material,table cutting.Yuan heel piece is put in drying device and is dried, and dry complete control moisture is in 5%-7%.
(3) Yuan root is pulverized and sterilizing: Yuan heel piece is pulverized, crossed 80 eye mesh screens, sterilizing, obtains Yuan root powder.
(4) sea-buckthorn is extracted: get qualified sea buckthorn fruit, with the alcohol reflux of 10-15%, extract three times, each extraction time is 1h, 250 order filter-cloth filterings;
(5) concentrated, dry: merge three fructus hippophae extracts in (4), be concentrated into thick paste shape, with heated-air circulation oven constant pressure and dry at 80 ℃, pulverized 80 eye mesh screens, sterilizing, obtains hippophae rhamnoides, control moisture in 5%-7%;
(6) mix: get (3) middle Yuan root powder and hippophae rhamnoides (5) and mix by prescription quality ratio, mix;
(7) granulate: the powder after mixing is above added to 80% ethanol of 0.1-0.2 times of mass ratio, stir and evenly mix, on 18-20 mesh sieve, granulate;
(8) dry, whole grain: heated-air circulation oven constant pressure and dry 3 hours at 60 ℃ for particle in will (7), cross whole of 20 mesh sieves;
(9) sterilization: above particle is put under uviol lamp to radiation sterilization 8 hours;
(10) compressing tablet: get above-mentioned particle and add appropriate amount of auxiliary materials and be pressed into the candy sheet of 0.5g-1g with tablet press machine.
(11) packing: get qualified packaging material, pack with packing machine.
Preferably, in described (4), add for the first time 15 times of 10% ethanol, second and third time adds respectively 10 times of amount 10% ethanol.
Preferably, in described (8), after dry, whole grain, pellet moisture content ﹤ 6%.
Preferably, in described (10), candy sheet specification is 0.5g/ sheet or 1.0g/ sheet.
The health products that a kind of described Yuan root hippophae rhamnoides patch is made.
The food that a kind of described Yuan root hippophae rhamnoides patch is made.
The medicine that a kind of described Yuan root hippophae rhamnoides patch is made.
Useful benefit:
1, the beneficial effect of formula, manufacture craft and the purposes of Yuan root hippophae rhamnoides patch of the present invention is: the concentration of the lipid compositions such as hyperlipemia plasma cholesterol, triglycerides, total fat surpasses arm's length standard.The main harm of hyperlipemia is to cause atherosclerotic.Present stage, the Chinese medicine of primary treatment hyperlipemia had SANSHEN JIANGZHI YE, dimension fat recovering capsule etc.Although these Chinese medicines have the effect of reducing blood lipid, rare have simultaneously treatment atherosclerotic effect.The present invention can be used for the treatment of high fat of blood and various blood vessel scleratheroma simultaneously, and effect is obviously better than the effect of single sea-buckthorn and Yuan root; Healthy wholefood, health food or medicine,, containing chemical synthesis composition, do not have no side effect, and mouthfeel is good; Feedstock capture is convenient, and cost is low, is convenient to produce, and is conducive to promote regional economic development.
Specifically:
Yuan root compatibility sea-buckthorn, during Yuan root appetite-stimulating indigestion-relieving, lower gas are wide, sea-buckthorn is promoting blood circulation and removing blood stasis, and dissolving phlegm is turbid, and the two complements each other, and plays relieving dyspepsia, and the effect of promoting blood circulation to remove blood stasis can be used for anti-curing hyperlipemia.This product is through verification experimental verification, the two compatibility of Yuan root and sea-buckthorn, can significantly reduce serum total cholesterol (TC) and the serum triglyceride (TG) of hyperlipidemia model rat, there is obvious synergistic effect, action effect is that more than single medicine 1.5-2 times formula for a product 3 is even better than positive control drug.And two taste Chinese medicines separately-act on while using not obvious.And invention has obvious antiatherosclerosis, and during the independent medication of this two tastes Chinese medicine, be showed no obvious antiatherogenic effect.
The specific embodiment
Below optimum implementation of the present invention is described in further detail.
Embodiment 1:
Formula for a product (1):
The mass ratio of Yuan root, hippophae rhamnoides is 3:7
Manufacture craft:
(1) feeding: get qualified Yuan root, sea buckthorn fruit;
(2) Yuan undercut sheet and dry: Yuan root is cut into slices with machine for traditional Chinese medicinal material,table cutting.Yuan heel piece is put in drying device and is dried, and dry complete control moisture is in 5%-7%.
(3) Yuan root is pulverized and sterilizing: Yuan heel piece is pulverized, crossed 80 eye mesh screens, sterilizing, obtains Yuan root powder.
(4) sea-buckthorn is extracted: get qualified sea buckthorn fruit, with the alcohol reflux of 10-15%, extract three times, each extraction time is 1h, 250 order filter-cloth filterings;
(5) concentrated, dry: three fructus hippophae extracts in combining step (4), be concentrated into thick paste shape, with heated-air circulation oven constant pressure and dry at 80 ℃, pulverized 80 eye mesh screens, sterilizing, obtains hippophae rhamnoides, controls moisture in 5%-7%;
(6) mix: get 3 parts, Yuan root powder and 7 parts of mixing in mass ratio of step (5) hippophae rhamnoides in step (3), mix;
(7) granulate: the powder after mixing is above added to 80% ethanol of 0.1-0.2 times of mass ratio, stir and evenly mix, on 18-20 mesh sieve, granulate;
(8) dry, whole grain: heated-air circulation oven constant pressure and dry 3 hours at 60 ℃ for particle in will (7), cross whole of 20 mesh sieves;
(9) sterilization: above particle is put under uviol lamp to radiation sterilization 8 hours;
(10) compressing tablet: get above-mentioned particle and add appropriate amount of auxiliary materials and be pressed into the candy sheet of 0.5g-1g with tablet press machine.
(11) packing: get qualified packaging material, pack with packing machine.
Embodiment 2:
Formula for a product (2):
The mass ratio of Yuan root, hippophae rhamnoides is 5:5
Manufacture craft:
(1) feeding: get qualified Yuan root, sea buckthorn fruit;
(2) Yuan undercut sheet and dry: Yuan root is cut into slices with machine for traditional Chinese medicinal material,table cutting.Yuan heel piece is put in drying device and is dried, and dry complete control moisture is in 5%-7%.
(3) Yuan root is pulverized and sterilizing: Yuan heel piece is pulverized, crossed 80 eye mesh screens, sterilizing, obtains Yuan root powder.
(4) sea-buckthorn is extracted: get qualified sea buckthorn fruit, with the alcohol reflux of 10-15%, extract three times, each extraction time is 1h, 250 order filter-cloth filterings;
(5) concentrated, dry: three fructus hippophae extracts in combining step (4), be concentrated into thick paste shape, with heated-air circulation oven constant pressure and dry at 80 ℃, pulverized 80 eye mesh screens, sterilizing, obtains hippophae rhamnoides, controls moisture in 5%-7%;
(6) mix: get 5 parts, Yuan root powder and 5 parts of mixing in mass ratio of step (5) hippophae rhamnoides in step (3), mix;
(7) granulate: the powder after mixing is above added to 80% ethanol of 0.1-0.2 times of mass ratio, stir and evenly mix, on 18-20 mesh sieve, granulate;
(8) dry, whole grain: heated-air circulation oven constant pressure and dry 3 hours at 60 ℃ for particle in will (7), cross whole of 20 mesh sieves;
(9) sterilization: above particle is put under uviol lamp to radiation sterilization 8 hours;
(10) compressing tablet: get above-mentioned particle and add appropriate amount of auxiliary materials and be pressed into the candy sheet of 0.5g-1g with tablet press machine.
(11) packing: get qualified packaging material, pack with packing machine.
Embodiment 3:
Formula for a product (3):
The mass ratio of Yuan root, hippophae rhamnoides is 4:6
Manufacture craft:
(1) feeding: get qualified Yuan root, sea buckthorn fruit;
(2) Yuan undercut sheet and dry: Yuan root is cut into slices with machine for traditional Chinese medicinal material,table cutting.Yuan heel piece is put in drying device and is dried, and dry complete control moisture is in 5%-7%.
(3) Yuan root is pulverized and sterilizing: Yuan heel piece is pulverized, crossed 80 eye mesh screens, sterilizing, obtains Yuan root powder.
(4) sea-buckthorn is extracted: get qualified sea buckthorn fruit, with the alcohol reflux of 10-15%, extract three times, each extraction time is 1h, 250 order filter-cloth filterings;
(5) concentrated, dry: three fructus hippophae extracts in combining step (4), be concentrated into thick paste shape, with heated-air circulation oven constant pressure and dry at 80 ℃, pulverized 80 eye mesh screens, sterilizing, obtains hippophae rhamnoides, controls moisture in 5%-7%;
(6) mix: get 4 parts, Yuan root powder and 6 parts of mixing in mass ratio of step (5) hippophae rhamnoides in step (3), mix;
(7) granulate: the powder after mixing is above added to 80% ethanol of 0.1-0.2 times of mass ratio, stir and evenly mix, on 18-20 mesh sieve, granulate;
(8) dry, whole grain: heated-air circulation oven constant pressure and dry 3 hours at 60 ℃ for particle in will (7), cross whole of 20 mesh sieves;
(9) sterilization: above particle is put under uviol lamp to radiation sterilization 8 hours;
(10) compressing tablet: get above-mentioned particle and add appropriate amount of auxiliary materials and be pressed into the candy sheet of 0.5g-1g with tablet press machine.
(11) packing: get qualified packaging material, pack with packing machine.
Embodiment 4:
Formula for a product (4):
The mass ratio of Yuan root, hippophae rhamnoides is 6:5
Manufacture craft:
(1) feeding: get qualified Yuan root, sea buckthorn fruit;
(2) Yuan undercut sheet and dry: Yuan root is cut into slices with machine for traditional Chinese medicinal material,table cutting.Yuan heel piece is put in drying device and is dried, and dry complete control moisture is in 5%-7%.
(3) Yuan root is pulverized and sterilizing: Yuan heel piece is pulverized, crossed 80 eye mesh screens, sterilizing, obtains Yuan root powder.
(4) sea-buckthorn is extracted: get qualified sea buckthorn fruit, with the alcohol reflux of 10-15%, extract three times, each extraction time is 1h, 250 order filter-cloth filterings;
(5) concentrated, dry: three fructus hippophae extracts in combining step (4), be concentrated into thick paste shape, with heated-air circulation oven constant pressure and dry at 80 ℃, pulverized 80 eye mesh screens, sterilizing, obtains hippophae rhamnoides, controls moisture in 5%-7%;
(6) mix: get 6 parts, Yuan root powder and 5 parts of mixing in mass ratio of step (5) hippophae rhamnoides in step (3), mix;
(7) granulate: the powder after mixing is above added to 80% ethanol of 0.1-0.2 times of mass ratio, stir and evenly mix, on 18-20 mesh sieve, granulate;
(8) dry, whole grain: heated-air circulation oven constant pressure and dry 3 hours at 60 ℃ for particle in will (7), cross whole of 20 mesh sieves;
(9) sterilization: above particle is put under uviol lamp to radiation sterilization 8 hours;
(10) compressing tablet: get above-mentioned particle and add appropriate amount of auxiliary materials and be pressed into the candy sheet of 0.5g-1g with tablet press machine.
(11) packing: get qualified packaging material, pack with packing machine.
Embodiment 5:
Formula for a product (5):
The mass ratio of Yuan root, hippophae rhamnoides is 3:9
Manufacture craft:
(1) feeding: get qualified Yuan root, sea buckthorn fruit;
(2) Yuan undercut sheet and dry: Yuan root is cut into slices with machine for traditional Chinese medicinal material,table cutting.Yuan heel piece is put in drying device and is dried, and dry complete control moisture is in 5%-7%.
(3) Yuan root is pulverized and sterilizing: Yuan heel piece is pulverized, crossed 80 eye mesh screens, sterilizing, obtains Yuan root powder.
(4) sea-buckthorn is extracted: get qualified sea buckthorn fruit, with the alcohol reflux of 10-15%, extract three times, each extraction time is 1h, 250 order filter-cloth filterings;
(5) concentrated, dry: three fructus hippophae extracts in combining step (4), be concentrated into thick paste shape, with heated-air circulation oven constant pressure and dry at 80 ℃, pulverized 80 eye mesh screens, sterilizing, obtains hippophae rhamnoides, controls moisture in 5%-7%;
(6) mix: get 3 parts, Yuan root powder and 9 parts of mixing in mass ratio of step (5) hippophae rhamnoides in step (3), mix;
(7) granulate: the powder after mixing is above added to 80% ethanol of 0.1-0.2 times of mass ratio, stir and evenly mix, on 18-20 mesh sieve, granulate;
(8) dry, whole grain: heated-air circulation oven constant pressure and dry 3 hours at 60 ℃ for particle in will (7), cross whole of 20 mesh sieves;
(9) sterilization: above particle is put under uviol lamp to radiation sterilization 8 hours;
(10) compressing tablet: get above-mentioned particle and add appropriate amount of auxiliary materials and be pressed into the candy sheet of 0.5g-1g with tablet press machine.
(11) packing: get qualified packaging material, pack with packing machine.
Embodiment 6:
Yuan root hippophae rhamnoides patch formula for a product 3, formula for a product 4, formula for a product 5 acute toxicity tests.
1 experiment material:
Kunming mouse, 120, male and female half and half, body weight 19-22g.
Experimental agents:
Yuan root hippophae rhamnoides patch formula for a product 4, formula for a product 5, formula for a product 3,100.0g, adult's consumption 2g/ days.
Collocation method: take five kinds of Yuan root hippophae rhamnoides patch powder 4g, be dissolved in 5ml water, be configured to 80% suspension maximum concentration.
2. experimental technique:
Prerun mouse stomach Yuan root hippophae rhamnoides patch formula for a product 3, formula for a product 4, formula for a product 5, each 8g/Kg of powder suspension, observes mouse toxicity reaction in 1 day and death condition, fails to measure three kinds of Yuan root hippophae rhamnoides patch mouse stomach LD50 values, therefore carry out maximum administration, separately tests.
Choose 120 qualified clean level Kunming mouses of health, each organizes 30, male and female half and half, compare with blank solution group, get Yuan root hippophae rhamnoides patch formula for a product 4, formula for a product 5, formula for a product 3 suspensions are all with 80%(0.8g/ml) administration concentration, by 0.2ml/10g body weight gavage, then freely drink water and look for food, observe 1 week, record the situations such as the 7th day mouse appetite, body weight, position, breathing, righting reflex.
3 experimental results and conclusion:
Each formula for a product 4 of mouse Yuan root hippophae rhamnoides patch, formula for a product 5,1 week interior nothing 1 example of formula for a product 3 suspension is dead, and feed and drinking-water etc. are without abnormal change, as shown in table 1:
The result of mouse situation after the Yuan root hippophae rhamnoides patch suspension oral gavage of three kinds of formulas of table 1:
Observe the 7th day, formula for a product 4, formula for a product 5, formula for a product 3 each groups are taken medicine mouse without dead and obviously anomaly discovery.Through cervical vertebra dislocation, put to death and dissect every animal and contrast with normal mouse, under bore hole, the five internal organs etc. are found without abnormal conditions.
Experimental result, after the Yuan root hippophae rhamnoides patch suspension oral gavage of three kinds of formulas, the maximum dosage-feeding of the Cmax of mouse is 16g/Kg, is 480 times (16g/Kg ÷ 2g/60Kg=480) that human clinical takes daily dose, and is showed no toxicity generation.
Embodiment 7:
Yuan root hippophae rhamnoides patch formula for a product 4, formula for a product 5, the impact of formula for a product 3 on hyperlipemia rat model effect for reducing blood fat.
1 materials and methods
1.1 sample Yuan root hippophae rhamnoides patch formula for a product 4, formula for a product 5, formula for a product 3 is by the production of Tibet Hong Xiang medical sci-tech development corporation, Ltd., censorship, and sample is sepia tablet, 0.3g/ sheet.Human body recommended amounts every day 3 times, each 3.Get tablet and pulverized 20 mesh sieves as tested material formula for a product 4, formula for a product 5, formula for a product 3.
1.2 animal SD male rats, 168, body weight 160～200g.
1.3 high lipid food 78.8% basal feeds, 1% cholesterol, 10% yolk powder, 10% lard, 0.2% bovine bile.
1.4 reagent and instrument TC, TG, HDL-C kit provide by Shanghai Ke Hua-Dong Ling diagnostic article Co., Ltd.Tester is the ADVIA1200 automatic clinical chemistry analyzer that Bayer is produced.
1.5 dosage deisgn product formulas 4, formula for a product 5, formula for a product 3 is respectively established basic, normal, high three dosage groups, be respectively 5 times, 10 times, 30 times of recommended amounts, be 0.23g/kgBM, 0.45g/kg BW, 1.35g/kgBW, separately establish a hyperlipidemia model control group, a Yuan root control group
(0.45g/kgBW), a sea-buckthorn control group (0.45g/kgBW), an Atorvastatin positive controls and a basal feed control group.Per os gives tested material, gavage amount 10ml/kgBM.1.6 test method basal feeds were fed rat after 8 days, spend the night and get tail blood on an empty stomach, survey serum total cholesterol (TC), serum triglyceride (TG), serum High Density Lipoprotein Cholesterol (HDL-C), according to TC level, be divided at random 11 groups, basic, normal, high three dosage groups of three kinds of formulas, hyperlipidemia model control group, a Yuan root control group (0.45g/kgBW), a sea-buckthorn control group (0.45g/kgBW), an Atorvastatin positive controls and a basal feed control group.Three dosage groups of three kinds of formulas in experimental period, hyperlipidemia model control group, a Yuan root control group (0.45g/kgBW), a sea-buckthorn control group (0.45g/kgBW), Atorvastatin positive controls give high lipid food and and the tested material of various dose, basal feed control group gives basal feed.In weighing for the 33rd day of test, fasting was got blood after 16 hours, surveyed serum total cholesterol, triglycerides, three indexs of HDL-C.
1.7 result treatment SPSS softwares carry out variance analysis.
2 results
2.1 Yuan root hippophae rhamnoides patch formula for a product 4, formula for a product 5, the impact of formula for a product 3 on the weight of animals
The impact of the Yuan root hippophae rhamnoides patch of three kinds of formulas of table 2 on the weight of animals
From table 2, after the Yuan root hippophae rhamnoides patch suspension oral gavage of three kinds of formulas, the initial weight of animal, mid-term are heavily, end is heavy and hyperlipidemia model control group comparing difference nonsignificance (p > 0.05), illustrates that the Yuan root hippophae rhamnoides patch of three kinds of formulas under this experimental condition has no significant effect the body weight of animal.
2.2 impacts of Yuan root hippophae rhamnoides patch on animal lipid
The Yuan root hippophae rhamnoides patch of three kinds of formulas of table 3 affects Serum TC
Note: compare * P<0.05, * * P<0.01 with hyperlipidemia model control group.
The impact of the Yuan root hippophae rhamnoides patch of three kinds of formulas of table 4 on rat blood serum TG
Note: compare * P<0.05, * * P<0.01 with hyperlipidemia model control group.
The impact of table 5 Yuan root hippophae rhamnoides patch on rat blood serum HDL-C
Note: compare P>0.05 with hyperlipidemia model control group
From table 3, table 4, hyperlipidemia model control animals serum TC, TG and basal feed control group comparing difference have extremely significantly meaning (P<0.01), illustrate that this test hyperlipidemia model is successfully established.Test the .45g/kgBW of rear three kinds of formulas 0, the Yuan root hippophae rhamnoides patch of 1.35g/kgBW dosage group can make TC in rat blood serum, TG reduce, with hyperlipidemia model control group comparing difference significance (P<0.05), obviously be better than sea-buckthorn group and these two simple groups of Yuan root group, and formula for a product 3 reduces the effect particularly evident (P<0.01) of TC, TG; HDL-C and hyperlipidemia model control group comparing difference nonsignificance (P>0.05) in each dosage group rat blood serum of the rear three kinds of formulas of the visible test of table 5, the Yuan root hippophae rhamnoides patch that three kinds of formulas are described has reducing effect to the TC in rat blood serum, TG, but the HDL-C in rat blood serum is not had to obvious effect.
Embodiment 8:
Yuan root hippophae rhamnoides patch formula for a product 4, formula for a product 5, the impact of formula for a product 3 on model of experimental atherosclerosis in rats.
1 materials and methods
1.1 sample Yuan root hippophae rhamnoides patch formula for a product 4, formula for a product 5, formula for a product 3 is by the production of Tibet Hong Xiang medical sci-tech development corporation, Ltd., censorship, and sample is sepia tablet, 0.3g/ sheet.Human body recommended amounts every day 3 times, each 3.Get tablet and pulverized 20 mesh sieves as tested material formula for a product 4, formula for a product 5, formula for a product 3.
1.2 animal SD male rats, 156, body weight 160～200g.
1.3 high lipid food 78.8% basal feeds, 1% cholesterol, 10% yolk powder, 10% lard, 0.2% bovine bile.
1.4 reagent and instrument TC, TG, HDL-C kit provide by Shanghai Ke Hua-Dong Ling diagnostic article Co., Ltd.Tester is the ADVIA1200 automatic clinical chemistry analyzer that Bayer is produced.
1.5 dosage deisgn product formulas 4, formula for a product 5, formula for a product 3 is respectively established basic, normal, high three dosage groups, be respectively 5 times, 10 times, 30 times of recommended amounts, be 0.23g/kgBM, 0.45g/kg BW, 1.35g/kgBW, separately establish a hyperlipidemia model control group, a Yuan root control group (0.45g/kg BW), a sea-buckthorn control group (0.45g/kgBW), an Atorvastatin positive controls and a basal feed control group.Per os gives tested material, gavage amount 10ml/kgBM.
1.6 test methods are divided into 13 groups at random, formula for a product 4, formula for a product 5, formula for a product 3 each three dosage groups, hyperlipidemia model control group, single Yuan root group, single sea-buckthorn group and a basal feed control group.Experimental period,, interior three dosage groups, single Yuan root group, single sea-buckthorn group and hyperlipidemia model control groups gave the tested material of high lipid food and various dose, and basal feed control group gives basal feed.In weighing for the 90th day of test, aorta ascendens 5mm is won in fasting after 16 hours, with lO% formalin, fixes, and observes aorta wall plaque deposition situation after HE dyeing, observes Yuan root hippophae rhamnoides patch to atherosclerotic impact.
2 results
Observe rat aorta Histological change.Each layer of structure of rats in normal control group aorta wall is normal, and inner membrance is smooth, and middle film elastic fibers is normal, has no AP.Compare with Normal group, hyperlipidemia model model group sustainer tube chamber diminishes, and inner membrance obviously thickens, and Lipid Plaque fills the air, and at inner membrance and middle film, all occurs a large amount of patches and inflammatory cell infiltration.Yet, the various dose Yuan root hippophae rhamnoides patch of three kinds of formula for a product is compared the equal aorta wall endometrial hyperplasia that can reduce hyperlipidemia model rat with model group, Lipid Plaque area (P<0.05), wherein, formula for a product 3 suppresses the aorta wall endometrial hyperplasia of hyperlipidemia model rat, the effect best (P<0.01) of Lipid Plaque area, still, single sea-buckthorn group and Yuan root group are there are no antiatherogenic effect.。
3 conclusions
The Yuan root hippophae rhamnoides patch of three kinds of different formulations all can be able to make TC, TG in hyperlipidemia model rat blood serum reduce, alleviate the aortal endometrial hyperplasia of atherosclerosis model rats, reduce Lipid Plaque area, with control group comparing difference significance (P<0.05), wherein the Yuan root hippophae rhamnoides patch of formula for a product 3 has auxiliary antilipemic and anti-angiogenic atherosis effect best (P<0.01).And sea-buckthorn is organized and these two simple groups of Yuan root group have the effect that reduces TC, TG in hyperlipidemia model rat blood serum, but curative effect is not as three formula for a product groups; Single sea-buckthorn group and Yuan root group are there are no antiatherogenic effect simultaneously.
Above content is the further description of the present invention being done in conjunction with concrete preferred embodiment, and being convenient to these those skilled in the art can understand and apply the invention, and can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, can also make without departing from the inventive concept of the premise some simple deduction or replace, and needn't pass through performing creative labour.Therefore, those skilled in the art are according to announcement of the present invention, and the simple modifications that the present invention is made all should be within protection scope of the present invention.
Claims (7)
1. a Yuan root hippophae rhamnoides patch, is characterized in that: main component is Yuan root, hippophae rhamnoides, and the mass ratio of described Yuan root, hippophae rhamnoides is 3-6:5-9.
2. according to right, want a kind of Yuan root hippophae rhamnoides patch described in 1, it is characterized in that, described hippophae rhamnoides makes by the following method: get qualified sea buckthorn fruit, the alcohol reflux with 10 ~ 15% extracts three times, and each extraction time is 1h, 250 order filter-cloth filterings; Concentrated, dry: merge three times fructus hippophae extract, be concentrated into thick paste shape, with heated-air circulation oven constant pressure and dry at 80 ℃, pulverized 80 eye mesh screens, sterilizing, obtains hippophae rhamnoides, control moisture in 5%-7%.
3. a preparation method for Yuan root hippophae rhamnoides patch claimed in claim 1, is characterized in that: comprise the following steps:
(1) feeding: get qualified Yuan root, sea buckthorn fruit;
(2) Yuan undercut sheet and dry: Yuan root is cut into slices with machine for traditional Chinese medicinal material,table cutting;
Yuan heel piece is put in drying device and is dried, and dry complete control moisture is in 5%-7%;
(3) Yuan root is pulverized and sterilizing: Yuan heel piece is pulverized, crossed 80 eye mesh screens, sterilizing, obtains Yuan root powder;
(4) sea-buckthorn is extracted: get qualified sea buckthorn fruit, the alcohol reflux with 10 ~ 15% extracts three times, and each extraction time is 1h, 250 order filter-cloth filterings;
(5) concentrated, dry: three fructus hippophae extracts in combining step (4), be concentrated into thick paste shape, with heated-air circulation oven constant pressure and dry at 80 ℃, pulverized 80 eye mesh screens, sterilizing, obtains hippophae rhamnoides, controls moisture in 5%-7%;
(6) mix: get Yuan root powder in (3) and hippophae rhamnoides (5) by the mass ratio of Yuan root, hippophae rhamnoides, be that 3-6:5-9 mixes, mix;
(7) granulate: the powder after mixing is above added to 80% ethanol of 0.1-0.2 times of mass ratio, stir and evenly mix, on 18 ~ 20 mesh sieves, granulate;
(8) dry, whole grain: heated-air circulation oven constant pressure and dry 3 hours at 60 ℃ for particle in will (7), cross whole of 20 mesh sieves;
(9) sterilization: above particle is put under uviol lamp to radiation sterilization 8 hours;
(10) compressing tablet: get above-mentioned particle and add appropriate amount of auxiliary materials and be pressed into the candy sheet of 0.5g-1g with tablet press machine;
(11) packing: get qualified packaging material, pack with packing machine.
4. the preparation method of Yuan root hippophae rhamnoides patch according to claim 3, is characterized in that: in described step (4), add for the first time 15 times of 10% ethanol, second and third time adds respectively 10 times of amount 10% ethanol.
5. the preparation method of Yuan root hippophae rhamnoides patch according to claim 2, is characterized in that: in described step (8), and after dry, whole grain, pellet moisture content ﹤ 6%.
6. the preparation method of Yuan root hippophae rhamnoides patch according to claim 2, is characterized in that: in described step (10), candy sheet specification is 0.5g/ sheet or 1.0g/ sheet.
7. the Yuan root hippophae rhamnoides patch described in a claim 1 or 2 reduces the application in high fat of blood, Antiatherosclerosis medicine, health products or food in preparation.
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| CN109430756A (en) * | 2018-12-07 | 2019-03-08 | 西宁途径农牧开发有限责任公司 | A kind of preparation method for the Yuan root powder removing acid |
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| CN115088765A (en) * | 2022-06-17 | 2022-09-23 | 青海省轻工业研究所有限责任公司 | Common turnip and sea buckthorn fruit milk and preparation method thereof |
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| CN101878908A (en) * | 2010-06-28 | 2010-11-10 | 崔晓廷 | Seabuckthorn fruit extract combined health care products and preparation method thereof |
| CN103431394A (en) * | 2013-08-30 | 2013-12-11 | 申大军 | Healthcare food and preparation method thereof |
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| SU1752396A1 (en) * | 1990-07-26 | 1992-08-07 | Научно-производственное объединение "Алтай" | Method for preparation of bioactive substance from sea- buckthorn |
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| CN101878908A (en) * | 2010-06-28 | 2010-11-10 | 崔晓廷 | Seabuckthorn fruit extract combined health care products and preparation method thereof |
| CN103431394A (en) * | 2013-08-30 | 2013-12-11 | 申大军 | Healthcare food and preparation method thereof |
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| CN104336263A (en) * | 2014-11-24 | 2015-02-11 | 周天 | Seabuckthorn leaves compound health protection tea and preparation method thereof |
| CN105362330A (en) * | 2015-11-27 | 2016-03-02 | 黑龙江众生生物工程有限公司 | Fructus hippophae blood-activating and stasis-removing tablet and preparation method thereof |
| CN108014150A (en) * | 2017-12-20 | 2018-05-11 | 浙江科技学院 | Application of the natural drug composition in anti anoxia and radiation-resistant medicine or food is prepared |
| CN108014150B (en) * | 2017-12-20 | 2021-05-11 | 浙江科技学院 | Application of natural medicine composition in preparing anti-hypoxia and anti-radiation medicine or food |
| CN109430756A (en) * | 2018-12-07 | 2019-03-08 | 西宁途径农牧开发有限责任公司 | A kind of preparation method for the Yuan root powder removing acid |
| CN111329907A (en) * | 2020-03-06 | 2020-06-26 | 西南交通大学 | Common turnip composition with anti-hypoxia function and preparation method and application thereof |
| CN113424955A (en) * | 2021-05-28 | 2021-09-24 | 才文昂江 | Common turnip chewing tablet |
| CN113827631A (en) * | 2021-11-17 | 2021-12-24 | 西藏藏医药大学 | A Tibetan medicinal compound for preventing and treating acute altitude sickness and its health care product |
| CN115088765A (en) * | 2022-06-17 | 2022-09-23 | 青海省轻工业研究所有限责任公司 | Common turnip and sea buckthorn fruit milk and preparation method thereof |
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| CN103704697B (en) | 2015-08-05 |
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