CN103704684A - Bone health product - Google Patents
Bone health product Download PDFInfo
- Publication number
- CN103704684A CN103704684A CN201210376544.9A CN201210376544A CN103704684A CN 103704684 A CN103704684 A CN 103704684A CN 201210376544 A CN201210376544 A CN 201210376544A CN 103704684 A CN103704684 A CN 103704684A
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- Prior art keywords
- vitamin
- care product
- health
- collagen
- skeleton
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a bone health product, which comprises collagen, glucosamine, vitamin and zinc source. The provided bone health product organically combines the collagen, glucosamine, vitamin and zinc source together, thereby the absorption is easy; the production of proteoglycan and collagen in human body can be promoted for supplementing the joint synovial fluid, and the necessary material of cartilage tissue for recovering the health after the joint is injured can be provided, the collagen formation is promoted, calcareous absorption and production can be promoted, and the bone health product is helpful for health care effect to human bone.
Description
Technical field
The invention belongs to nutriment field, be specially a kind of skeleton health-care product.
Background technology
Maintaining of bone health is sizable associated because have with dietetic nutrition picked-up and lifestyle.For arthritis and patients with osteoporosis, be often engaged in bone and the joint care aspects such as physical labourer, sportsman or the elderly; bone health is had to higher demand; people often can take some skeleton health-care product, to delaying the degeneration in bone or joint.
Recently the relation of vitamin D and bone health also often comes into question.Vitamin D has the effect of promotion enteron aisle to calcareous absorption; And vitamin D is also relevant with the eubolism function of bone cells.But, take separately the medicines such as gucosamine, vitamin D, can not make each active ingredient work in coordination with and play a role, and dosage is restive.Current existing skeleton health-care product have the products such as glucose osamine, calcium, and liquid state, powder or chalybeate product are made with folk prescription or compound form by aforementioned gucosamine, the general system of calcium.When people are oral, a part for aforementioned liquid state, powder or chalybeate skeleton health-care product is easily for saliva is decomposed, and affect human body for the composition assimilation effect of skeleton health-care product, as for liquid and Powdered skeleton health-care product, be not easy to user and carry the defects such as oral.
Summary of the invention
The present invention's main purpose is to provide a kind of structure of skeleton health-care product, wishes therefore to solve existing skeleton health-care product and is not easy to carry oral, and easily for saliva dissolves, affects the problems such as absorption when oral.
The technical scheme that realizes above-mentioned purpose of the present invention is:
Skeleton health-care product, it comprises: collagen (Collagen), gucosamine (Glucosamine), vitamin and zinc source.
Preferably, described skeleton health-care product comprise the constituent of weight portion: the zinc source of the gucosamine of the collagen of 40-80 part, 10-20 part, the vitamin of 0.1-0.5 part and 0.05-0.5 part.
More preferably, described skeleton health-care product comprise the constituent of weight portion: the zinc source of the gucosamine of the collagen of 50-90 part, 5-10 part, the vitamin of 0.2-1 part and 0.01-0.5 part.
The formed network structure of described collagen, can be coated wherein by its cartilage cell's glucoprotein and albumen candy, and moisture is retained in network structure.The conversion of the complete and natural composition of collagen by coenzyme in body just can post-equalization, thereby Articular Cartilage and connective tissue improve the pain in joint, osteoporotic situation.
Described gucosamine is a kind of amido sugar in human body, is that the glutinous polysaccharide component (being a kind of constituent of polysaccharide body) with viscosity is present in cartilage and connective tissue everywhere, is also to form one of most important nutrient of cartilage cell.In mankind's body, can synthesize voluntarily grape amine, just, along with the increase at age, synthetic speed is unable to catch up with the speed of decomposing, then there is the phenomenon of body endoskeleton and joint shortage grape amine, and then affect the metabolism of joint inner cell.The gucosamine of selecting during skeleton health-care product composition of the present invention divides can be decomposed into amino acid in human body, can convert galactolipin to, also can convert chondroitin to, by supplementing of gucosamine, can promote the manufacture of the interior proteoglycan of body and collagen, supplement knuckle synovia, and can provide injured posterior joint to recover the necessary material of its healthy cartilaginous tissue.
Collagen can make calcareous and osteocyte combine closely can not run off, therefore can contribute to human body to delay the degeneration in bone or joint; Vitamin D can be through the further conversion calcitriol of liver and kidney, as a kind of hormone, reenter circulation, regulate the absorption of calcium and phosphorus, promote growth and the reconstruct of bone, vitamin D can be used for preventing child rickets and adult bone malacosis, and vitamin D and calcium share and can prevent senile osteoporosis; Vitamin C can promote the formation of collagen, and promotes that calcareous absorption, aforementioned collagenic protein are between the tissue and dentin cell of the connective tissue, blood vessel and the bone that are present in human body; Zinc is one of important component in the blood of human body and bone.
Wherein, described vitamin is vitamin C (Vitamin-C) and vitamin D (Vitamin-D), and the part by weight of the two is 3000-15000:1.
Preferably, the part by weight of described vitamin C and vitamin D is 5000-25000:1.
Wherein, described zinc source is one or more in zinc citrate, zinc gluconate, licorzinc, zinc glutamate, Yeast protein zinc.
Wherein, described skeleton health-care product are comprised of described active ingredient and pharmaceutically acceptable carrier or diluent solid pharmaceutical preparation or liquid preparation.
Wherein, described pharmaceutically acceptable carrier or diluent are selected from one or more in xylitol, D-sorbite, isomalt, isomaltoketose, starch, dextrin, water, microcrystalline cellulose, lactose, sucrose, gelatin, HPMC, soybean oil, phosphatide, dolomol.
Wherein, described solid pharmaceutical preparation is selected from tablet, capsule, granule or pulvis, is preferably granule; Described liquid preparation is oral liquid.
A method of preparing the skeleton health-care product that the present invention proposes, it is to take in proportion collagen, gucosamine, vitamin and zinc source granulation, after the molten film of coated stomach granule.
The application of the skeleton health-care product that the present invention proposes in body-care.
Beneficial effect of the present invention is:
The skeleton health-care product that the present invention proposes are organically combined collagen, gucosamine, vitamin and zinc source, are easy to absorb; Not only can promote the manufacture of the interior proteoglycan of body and collagen, supplement knuckle synovia, can also provide injured posterior joint to recover the necessary material of its healthy cartilaginous tissue, promote the formation of collagen, and promote calcareous absorption to produce, contribute to the health care effectiveness of skeleton.
The specific embodiment
Now with following most preferred embodiment, the present invention is described, but is not used for limiting the scope of the invention.In embodiment, if no special instructions, equipment and the method for field routine under the equipment using and method are.
The gucosamine using in example of the present invention is purchased from Zhejiang Tianyi Food Additives Co., Ltd., collagen is purchased from osmanthus, Xiamen Yu Shi commerce and trade Co., Ltd, vitamin C is purchased from Xiamen Zhen Xuan trade Co., Ltd, vitamin D is purchased from Xiamen Zhen Xuan trade Co., Ltd, and zinc citrate and zinc gluconate are purchased from Xiamen Zhen Xuan trade Co., Ltd.
Embodiment 1:
Take the constituent of weight portion: 40 parts of collagens, 10 parts of gucosamines, 0.1 part vitamin C and D, wherein vitamin D accounts for 0.02wt%, the zinc citrate of 0.05 part; Stir, with granulator granulation, the particle of screening particle diameter 0.02-0.05mm, is granule.
The present invention's skeleton health-care product, it is utilization granulator granulation, the particle that sieves out particle diameter 0.4-0.8mm contains the particle that skeleton health-care becomes minute so that oral these skeleton health-care product of people, when oral by this granule mixing in water for oral taking.Until skeleton health-care product, reach after human stomach, can be gastric juice and dissolve fast, make to contain the particle that skeleton health-care becomes minute and disperse, and absorbed by human body for gastric juice dissolves, make skeleton health-care composition in particle can bring into play the health care effectiveness of its useful skeleton.
Embodiment 2:
Take the constituent of weight portion: 60 parts of collagens, 15 parts of gucosamines, vitamin C and the D of 0.3 part, wherein vitamin D accounts for 0.02wt%, the zinc lactate of 0.275 part; Stir, with granulator granulation, sieve out the particle of particle diameter 0.3-0.5mm, obtain granule.
Embodiment 3:
Take the constituent of weight portion: 80 parts of collagens, 20 parts of gucosamines, 0.5 part vitamin C and D, wherein vitamin D accounts for 0.008wt%, and the zinc acetate of 0.5 part; Stir, with granulator granulation, sieve out the particle of particle diameter 0.5-0.8mm, obtain granule.
Embodiment 4:
Take the constituent of weight portion: 70 parts of collagens, 7.5 parts of gucosamines, the vitamin C of 0.6 part and D, wherein vitamin D accounts for the zinc lactate of 0.02wt% and 0.255 part; Stir, with granulator granulation, sieve out the particle of particle diameter 0.8-0.9mm, obtain granule.
Embodiment 5
Take the constituent of weight portion: 90 parts of collagens, 10 parts of gucosamines, vitamin C and the D of 1 part; wherein vitamin D accounts for the zinc lactate of 0.005wt% and 0.5 part; add cane sugar powder to mix, granulation, dry, whole grain mix, pack, pack, and obtain granule.
Experimental example 1
For inquiring into the increase bone density effect of skeleton health-care product, basic, normal, high three dosage groups are established in experiment, separately establish a low amount collagen control group and a high collagen control group, basic, normal, high three dosage groups are respectively with 200,400,122mg/kg ﹒ bw(is equivalent to 5,10,30 times of human body RDs) the collagen compound (embodiment 1 product) of dosage.Give rat oral gavage 13WK, drink deionized water and ingest containing the feed of collagen (this skeleton health-care product), measure rat height, femur calcium content and bone density apparent absorption rate etc. and see mutually index.Result experiment high dose group animal femur mid point and distal bone density, calcium content of bone, femur weight are higher than the collagen control group of low dosage collagen control group and corresponding dosage.Conclusion: after two months, the absorptivity of calcium of taking these collagen skeleton health-care product is higher, has the effect that increases rat bone density.
Table 1: on the impact of femur weight, calcium content of bone, bone density (n=10, x ± s)
Note: △ △ represents low dosage collagen control group and the collagen control group P < 0.01 that relatively declines; *, * * represents that respectively dosage group and collagen control group relatively increase P < 0.05, P < 0.01.
Results of animal shows, health products of the present invention have obvious enhancing effect to bone.
Above embodiment is described the preferred embodiment of the present invention; not scope of the present invention is limited; design under the prerequisite of spirit not departing from the present invention; various modification and improvement that the common engineers and technicians in this area make technical scheme of the present invention, all should fall in the definite protection domain of claims of the present invention.
Claims (10)
1. skeleton health-care product, is characterized in that, the active ingredient of these skeleton health-care product comprises: collagen, gucosamine, vitamin and zinc source.
2. skeleton health-care product as claimed in claim 1, is characterized in that, described active ingredient comprises the constituent of weight portion: the zinc source of the gucosamine of the collagen of 40-80 part, 10-20 part, the vitamin of 0.1-0.5 part and 0.05-0.5 part.
3. skeleton health-care product as claimed in claim 2, is characterized in that, described active ingredient comprises the constituent of weight portion: the zinc source of the gucosamine of the collagen of 50-90 part, 5-10 part, the vitamin of 0.2-1 part and 0.01-0.5 part.
4. skeleton health-care product as claimed in claim 1, is characterized in that, described vitamin is vitamin C and vitamin D, and the part by weight of the two is 3000-15000:1.
5. skeleton health-care product as claimed in claim 3, is characterized in that, the part by weight of described vitamin C and vitamin D is 5000-250000:1.
6. skeleton health-care product as claimed in claim 1, is characterized in that, described zinc source is one or more in zinc citrate, zinc gluconate, licorzinc, zinc glutamate, Yeast protein zinc.
7. skeleton health-care product as claimed in claim 1, is characterized in that, solid pharmaceutical preparation or liquid preparation that described skeleton health-care product are comprised of described active ingredient and pharmaceutically acceptable carrier or diluent.
8. skeleton health-care product as claimed in claim 7, it is characterized in that, described pharmaceutically acceptable carrier or diluent are selected from one or more in xylitol, D-sorbite, isomalt, isomaltoketose, starch, dextrin, water, microcrystalline cellulose, lactose, sucrose, gelatin, HPMC, soybean oil, phosphatide, dolomol.
9. skeleton health-care product as claimed in claim 7, is characterized in that, described solid pharmaceutical preparation is selected from tablet, capsule, granule or pulvis, is preferably granule; Described liquid preparation is oral liquid.
10. the application of the arbitrary described skeleton health-care product of claim 1-7 in body-care.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210376544.9A CN103704684A (en) | 2012-09-29 | 2012-09-29 | Bone health product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210376544.9A CN103704684A (en) | 2012-09-29 | 2012-09-29 | Bone health product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103704684A true CN103704684A (en) | 2014-04-09 |
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ID=50398356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210376544.9A Pending CN103704684A (en) | 2012-09-29 | 2012-09-29 | Bone health product |
Country Status (1)
| Country | Link |
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| CN (1) | CN103704684A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105725190A (en) * | 2016-02-15 | 2016-07-06 | 北京东方兴企食品工业技术有限公司 | Functional nutrient food for improving joints |
| CN113729230A (en) * | 2020-05-29 | 2021-12-03 | 安琪纽特股份有限公司 | Composition for preventing osteoporosis or enhancing bone mineral density and preparation and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6447809B1 (en) * | 1999-05-11 | 2002-09-10 | Metagenics, Inc. | Composition for promoting healthy bone structure |
| JP2005232089A (en) * | 2004-02-19 | 2005-09-02 | Aloe Seiyaku Kk | Orally administrable functional agent having bone quantity-increasing activity |
| CN1733297A (en) * | 2005-08-22 | 2006-02-15 | 北京东方兴企食品工业技术有限公司 | Joint nutrient tablet |
| CN101416734A (en) * | 2008-12-02 | 2009-04-29 | 河北金汉方生物科技开发有限公司 | Health-care products capable of improving skeleton and joint function and preparation method thereof |
| CN101720928A (en) * | 2008-10-27 | 2010-06-09 | 柯宏 | Combination for preventing and curing degenerative disease of bone and joint |
| CN101861961A (en) * | 2010-01-21 | 2010-10-20 | 海南京润珍珠生物技术股份有限公司 | Pearl bone strengthening health-care product |
| CN102091324A (en) * | 2011-03-15 | 2011-06-15 | 徐世祥 | Calcium for nourishing bones |
| CN102224896A (en) * | 2011-05-13 | 2011-10-26 | 营养屋(成都)生物医药有限公司 | Health food for enhancing human immunity and increasing bone mineral density and preparation method thereof |
-
2012
- 2012-09-29 CN CN201210376544.9A patent/CN103704684A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6447809B1 (en) * | 1999-05-11 | 2002-09-10 | Metagenics, Inc. | Composition for promoting healthy bone structure |
| JP2005232089A (en) * | 2004-02-19 | 2005-09-02 | Aloe Seiyaku Kk | Orally administrable functional agent having bone quantity-increasing activity |
| CN1733297A (en) * | 2005-08-22 | 2006-02-15 | 北京东方兴企食品工业技术有限公司 | Joint nutrient tablet |
| CN101720928A (en) * | 2008-10-27 | 2010-06-09 | 柯宏 | Combination for preventing and curing degenerative disease of bone and joint |
| CN101416734A (en) * | 2008-12-02 | 2009-04-29 | 河北金汉方生物科技开发有限公司 | Health-care products capable of improving skeleton and joint function and preparation method thereof |
| CN101861961A (en) * | 2010-01-21 | 2010-10-20 | 海南京润珍珠生物技术股份有限公司 | Pearl bone strengthening health-care product |
| CN102091324A (en) * | 2011-03-15 | 2011-06-15 | 徐世祥 | Calcium for nourishing bones |
| CN102224896A (en) * | 2011-05-13 | 2011-10-26 | 营养屋(成都)生物医药有限公司 | Health food for enhancing human immunity and increasing bone mineral density and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105725190A (en) * | 2016-02-15 | 2016-07-06 | 北京东方兴企食品工业技术有限公司 | Functional nutrient food for improving joints |
| CN105725190B (en) * | 2016-02-15 | 2018-09-25 | 北京东方兴企食品工业技术有限公司 | A kind of functional nutrient food of joint-improving |
| CN113729230A (en) * | 2020-05-29 | 2021-12-03 | 安琪纽特股份有限公司 | Composition for preventing osteoporosis or enhancing bone mineral density and preparation and application thereof |
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Application publication date: 20140409 |