CN103690962B - A kind of dog independently searches for food type pharmaceutical carrier and preparation method thereof - Google Patents

Abstract

The present invention relates to a kind of dog independently to search for food type pharmaceutical carrier and preparation method thereof, by mass percentage, this product is made up of following component: Carnis Gallus domesticus 15-30%, white sugar 0.5-3%, carrageenan 0.2-1.2%, citric acid 0.05-0.3%, sodium erythorbate 0.1-0.3%, compound vitamin 0.01-2%, composite mineral matter 0.1-2%, potassium sorbate 0.02-0.05%, moisture 66-84%.Product of the present invention is suitable for direct feeding, be used for preventing and treating dog common clinical disease, reach disease preventing and treating and constitutional double effects, simultaneously this pharmaceutical carrier there is good palatability, can independently search for food, the advantage such as easy to use, solve and gavage and the problem such as operation that drug administration by injection brings is wasted time and energy, Animal stress reaction and pain.In addition, the production technology of product of the present invention is simple, and raw material sources are extensive, and production cost is low, is applicable to large-scale production.

Description

A kind of drug carrier of dog self-eating type and preparation method thereof

technical field

The invention belongs to the technical field of animal medicine, and relates to a formula and a preparation method of a novel dog self-eating type drug carrier.

Background technique

In recent years, the number of pet breeding in my country has grown rapidly, among which dogs and cats account for about 60-70% of pet breeding. According to statistics, the number of dogs in mainland China is as high as 150-200 million. With the increase in the number of dogs bred, the number of sick dogs also increases. The common diseases of dogs include diarrhea, enteritis, and parasitic diseases. Health, bring great economic loss to the dog industry.

At present, the methods of drug administration for clinical diseases of dogs mainly include injections, tablets, granules, powders, liquids, etc., but there are deficiencies, such as the use of injections, mostly intramuscular injection and intravenous injection. Produce resistance and stress response, which may cause unnecessary harm to people. In addition, the injection requires professional and technical personnel to personally operate, which has certain limitations and may also have the risk of spreading diseases; most of the tablets are bitter, and dogs Reluctance to actively ingest, often vomits medicine, which is not conducive to feeding; granules and powders are mostly granules and powders, which need to be evenly mixed into feed for use, suitable for group feeding, not suitable for individual feeding of pet dogs; and liquid preparations generally need to be fed one by one Hello, it is not convenient to use.

Therefore, the development of methods for the prevention and treatment of clinical diseases in dogs should further search for new therapeutic dosage forms to enable them to actively ingest food and have good palatability. The common clinical diseases of dogs can be prevented and treated by feeding, and the prevention and treatment effect is obvious.

According to the nutritional needs of dogs, the present invention develops a drug carrier for dogs to eat independently. The carrier contains essential nutrients for dogs such as protein, fat, vitamins and minerals, and can be used as a diet to provide comprehensive nutrition for dogs. Drugs can also be added to achieve the purpose of preventing and treating diseases. The carrier has the advantages of self-ingestion, good palatability, and convenient use, and provides a new way for the prevention and treatment of canine clinical diseases.

Contents of the invention

The purpose of the present invention is to develop a drug carrier for dogs to eat independently, and further improve the preparation method of the drug carrier, and apply it to the prevention and treatment of common clinical diseases in dogs by feeding, so as to achieve the dual effects of preventing and curing diseases and enhancing physical fitness , significantly reduce the disease incidence and fatality rate of dogs, improve the cure rate, and overcome the shortcomings of the existing clinical administration methods.

The dog self-eating type drug carrier of the present invention, its mass percentage composition is as follows:

Chicken 15-30%

White sugar 0.5-3%

Carrageenan 0.2-1.2%

Moisture 66-84%

In addition to the above-mentioned basic carrier components, one or more of the following components can also be added to obtain a strengthened dog voluntary feeding type drug carrier, each component and its mass percentage are:

The chicken meat has a protein content of 16-23%, a fat content of 1.2-3.2%, and has high nutritional value.

The preparation method of the self-eating drug carrier for dogs disclosed by the present invention is as follows: adding 15-30% by mass of chicken, 0.5-3% white granulated sugar and 0.2-1.2% carrageenan into a container, adding water and stirring evenly, heating and boiling for 20 -30min, remove impurities and foam therein to obtain a sticky mixture, fill it into a sterilized packaging cup, seal it immediately and pasteurize it, and obtain the drug carrier of dog self-eating type after cooling.

The preparation method of the enhanced self-eating drug carrier for dogs disclosed by the present invention is as follows: adding 15-30% of chicken meat, 0.5-3% white sugar and 0.2-1.2% carrageenan into a container, adding water and stirring evenly, Heat and boil for 20-30 minutes to remove impurities and foam, then add one or more of citric acid, sodium erythorbate, multivitamins, multiminerals and potassium sorbate, and mix well to obtain a sticky mixture , filled into sterilized packaging cups, immediately sealed and pasteurized, and after cooling, the dog self-eating type drug carrier was obtained.

The beneficial effects of the present invention are: (1) adding nutrients such as protein, fat, compound vitamins and compound minerals, and condiments such as citric acid and white sugar, the taste, flavor and apparent texture are good, meeting the nutritional needs of pets, palatable Good sex. (2) Therapeutic drugs can be encapsulated in the drug carrier to cover up the bitter taste and not affect the feed intake. Dogs can eat food independently, which is convenient and efficient. (3) The preparation is simple, the cost is low, there are no toxic and side effects, the source of raw materials is wide, the use is convenient, and it is easy to promote.

detailed description

The present invention will be further described below in conjunction with embodiment.

Example 1:

Add 300g of chicken, 26g of white sugar and 10g of carrageenan into the container, add 663.34g of water, stir evenly, heat and boil for 30min, remove the impurities and foam in it, and obtain the drug carrier, then add 0.16g of gentamicin into the drug carrier, After mixing, add 0.5g preservative potassium sorbate to make 1000g dog self-eating drug carrier, then pour it into 40 sterilized 25g small packaging cups, immediately seal and pasteurize, cool and store at room temperature .

Example 2:

Add 150g of chicken, 5g of white sugar and 3g of carrageenan into the container, add 836.94g of water and stir evenly, heat and boil for 20 minutes to remove impurities and foam, then add 0.5g of citric acid, 2g of sodium erythorbate, 0.1g of multivitamins, 2g of compound minerals were prepared to obtain the drug carrier, then 0.16g of gentamycin was added to the drug carrier, and after mixing, 0.3g of preservative potassium sorbate was added to make 1000g of dog self-eating type drug carrier, and then poured into In 40 sterilized 25g small packaging cups, immediately seal and pasteurize, cool and store at room temperature.

Example 3:

Add 200g of chicken, 10g of white sugar and 6g of carrageenan into the container, add 780.14g of water, stir evenly, heat and boil for 25min, remove impurities and foam, then add 1g of citric acid, 1g of sodium erythorbate, 0.5g of multivitamins, 1g Composite minerals were prepared to obtain the drug carrier, then 0.16g gentamicin was added to the drug carrier, and after mixing, 0.2g preservative potassium sorbate was added to make 1000g dog self-eating type drug carrier, and then poured into 40 In a sterilized 25g small packaging cup, immediately seal and pasteurize, cool and store at room temperature.

Clinical Trials:

(1) Product stability test

The prepared drug carrier containing 0.004% gentamicin was placed at room temperature, and after 12 months of observation and detection, the results showed that the color, smell and taste of the drug carrier of the dog self-eating type had no significant changes, and gentamicin The relative content of the drug only decreased by 6%, and the preservation rate of drug activity was still as high as 94%. Therefore, the shelf life of the drug carrier of the present invention is not less than one year.

(2) Palatability test

20 experimental animal dogs were randomly divided into two groups, 10 in each group. The experimental group was fed with a drug carrier containing 0.004% gentamycin, and the control group was fed with a drug carrier without gentamicin, 1-2 times a day. After 2 days, the results showed that both the control group and the experimental group were all eaten within 1-2 minutes, indicating that the drug carrier was successfully coated, masked the bitter taste, did not affect the feed intake, had good palatability, and was suitable for pets to eat independently.

(3) Treatment effect test

60 adult dogs suffering from diarrhea were obtained from a dog farm in Dalian City, aged 1-3 years, and were randomly divided into three groups, A, B, and C, with 20 dogs in each group. Group A was fed with a common drug carrier without gentamicin , Group B was fed with a drug carrier containing 0.004% gentamicin, each drug carrier was 25g, 0.5-1 for small dogs, 1-2 for medium-sized dogs, 2-3 for large dogs, and intramuscular injection of gentamicin for group C Small dogs are injected with 0.5-1mg, medium-sized dogs are injected with 1-2mg, and large dogs are injected with 2-3mg, twice a day for 3 consecutive days. They are kept in the same environment, and the therapeutic effect is observed every day. After 3 days, comprehensive statistics are made. The results are shown in the following table Shown:

Table 1 Therapeutic effect of dog self-eating type drug carrier

The results show that the cure rate of the common drug carrier control group without gentamicin is 10%, and the total effective rate reaches 20%; the cure rate of the drug carrier experimental group containing 0.004% gentamicin is as high as 80%. The total effective rate reaches 90%; the cure rate of the intramuscular injection gentamicin control group is 75%, and the total effective rate reaches 85%. The experimental group is better than the matched group, indicating that the therapeutic effect of the present invention is better and the cure rate is high.

In the above-mentioned embodiments, the invention describes the possible implementation modes, and describes the present invention by means of illustrative examples, but the cited examples will not limit the protection scope of the claims of the present invention.

Claims (2)

1. dog independently searches for food a type pharmaceutical carrier, it is characterized in that, this dog type pharmaceutical carrier of independently searching for food comprises 15-30% Carnis Gallus domesticus, 0.5-3% white sugar, 0.2-1.2% carrageenan and 66-84% moisture, and above each component is prepared by mass percentage;

Described dog independently search for food that type pharmaceutical carrier also comprises in citric acid, sodium erythorbate, compound vitamin, composite mineral matter and potassium sorbate more than one; The percentage ratio that each component accounts for carrier gross mass is respectively:

Citric acid 0.05-0.3%;

Sodium erythorbate 0.1-0.3%;

Compound vitamin 0.01-2%;

Composite mineral matter 0.1-2%;

Potassium sorbate 0.02-0.05%.

2. a kind of dog described in claim 1 independently searches for food the preparation method of type pharmaceutical carrier, and its characterization step is as follows:

The Carnis Gallus domesticus of mass percent 15-30%, 0.5-3% white sugar and 0.2-1.2% carrageenan are added in container, add water and stir, heated and boiled 20-30min, remove impurity wherein and foam, then add one or more in citric acid, sodium erythorbate, compound vitamin, composite mineral matter and potassium sorbate, mixing, obtained glutinous sliding mixture, be filled in the packaging cup of having sterilized, seal immediately and carry out pasteurization, obtain dog after cooling and independently to search for food type pharmaceutical carrier.