CN103689487B - Pomegranate peel and Chinese yam dispersible tablet and preparation method thereof - Google Patents

Abstract

The invention discloses a pomegranate peel and yam dispersible tablet, comprising the following components in parts by weight: 100-300 parts of red pomegranate peel, 100-300 parts of yam, 80-120 parts of honeysuckle, 1.75-3.75 parts of vitamin C, 0.01-0.02 parts of vitamin A, 0.15-0.35 parts of zinc gluconate, 40-60 parts of microcrystalline cellulose, 0.12-0.32 parts of hawthorn extract, 0.12-0.32 parts of American ginseng extract, 100-170 parts of mannitol, 1.2-3.2 parts of chitosan oligosaccharide, 1.2-3.2 parts of crude polysaccharide, 10-15 parts of sucralose, 10-50 parts of micropowder silica gel, 3-5 parts of carboxymethyl cellulose, 55-80 parts of sodium carboxymethyl starch, 4-6 parts of magnesium stearate, an appropriate amount of purified water, and an appropriate amount of 75% concentration ethanol. The invention has the functions of invigorating the spleen and stopping diarrhea, and is suitable for children with diarrhea.

Description

A kind of pomegranate yam dispersible tablet and preparation method thereof

technical field

The invention belongs to the field of nutrition and health food, in particular to a pomegranate peel yam dispersible tablet and a preparation method thereof.

Background technique

Diarrhea in children is a group of diseases mainly caused by multiple pathogens and factors. The main features are increased stool frequency and changes in properties, which may be accompanied by symptoms such as fever, vomiting, abdominal pain, and varying degrees of water, electrolyte, and acid-base balance disorders. Pathogens can be viruses, bacteria, mainly human rotavirus and other enteroviruses, pathogenic Escherichia coli, toxigenic Escherichia coli, hemorrhagic Escherichia coli, invasive Escherichia coli

Enterobacteriaceae, Salmonella typhimurium, Campylobacter jejuni, Yarrowia, Staphylococcus aureus and other parasites and fungi. Extraintestinal infection, intestinal flora disorder caused by antibiotic abuse, allergies, improper feeding and climate factors can also cause disease. It is a common disease in infants under 2 years old. At present, although there are many Chinese patent medicines or formulas for children with diarrhea, although there are many prescriptions for treatment, they all appear in the form of medicines, and there are few dietotherapy products suitable for long-term consumption as adjuvant treatment. Therefore, it is very practical to research and develop a dietotherapy product for safe adjuvant therapy.

Contents of the invention

In view of the above situation, the technical problem to be solved by the present invention is to provide a kind of pomegranate yam dispersible tablet for invigorating the spleen and antidiarrheal and its preparation method, so as to solve the problems raised in the above-mentioned background technology.

To achieve the above object, the present invention provides the following technical solutions:

A yam dispersible tablet with pomegranate peel, comprising the following ingredients in parts by weight: 100-300 parts of red pomegranate peel, 100-300 parts of yam, 80-120 parts of honeysuckle, 1.75-3.75 parts of vitamin C, 0.01-0.02 parts of vitamin A, gluconic acid Zinc 0.15-0.35 parts, microcrystalline cellulose 40-60 parts, hawthorn extract 0.12-0.32 parts, American ginseng extract 0.12-0.32 parts, mannitol 100-170 parts, chitooligosaccharide 1.2-3.2 parts, crude polysaccharide 1.2- 3.2 parts, 10-15 parts of sucralose, 10-50 parts of micropowder silica gel, 3-5 parts of carboxymethyl cellulose, 55-80 parts of sodium carboxymethyl starch, 4-6 parts of magnesium stearate, appropriate amount of purified water , 75% concentration of ethanol in an appropriate amount.

As a preference, said a kind of pomegranate peel yam dispersible tablet comprises the following ingredients in parts by weight: 200 parts of red pomegranate peel, 200 parts of Chinese yam, 100 parts of honeysuckle, 2.75 parts of vitamin C, 0.015 parts of vitamin A, 0.25 parts of zinc gluconate, 50 parts of microcrystalline cellulose, 0.22 parts of hawthorn extract, 0.22 parts of American ginseng extract, 135 parts of mannitol, 2.2 parts of chitosan oligosaccharide, 2.2 parts of crude polysaccharide, 12.5 parts of sucralose, 30 parts of micro-powder silica gel, carboxymethyl fiber 4 parts of plain, 67.5 parts of sodium carboxymethyl starch, 5 parts of magnesium stearate, appropriate amount of purified water, appropriate amount of 75% ethanol.

A preparation method of yam dispersible tablet with pomegranate peel, comprising the following steps:

(1) Take fresh yam and wash it, soak it in 0.1% vitamin C aqueous solution for 15-20 minutes, put the soaked yam into a freeze dryer for freeze drying, first turn on the freezer for refrigeration, and freeze to the temperature of the raw material yam In the range of -20 to -30°C, keep it dry for 8-10 hours, then turn on the vacuum, and heat to 95-100°C, continue to dry for 1-3 hours, and crush the solid matter obtained by the above freeze-drying to obtain Chinese yam Freeze-dried powder, spare;

(2) Wash the raw materials red pomegranate peel and honeysuckle, add 4-5 times the total weight of the above raw materials in purified water, decoct at 90-100°C for 2-2.5 hours, filter, add 2 - 4 times the amount of purified water, decoct in the range of 90-100 °C for 1-1.5 hours, filter, discharge the filter residue, combine the two filtrates, and concentrate until the specific gravity is 1-1.5, add 1-2‰ of γ-starch Enzymes, keep warm at 35-45°C for 5-10 hours, and finally boil for 25-35 minutes before filtering to obtain a mixed extract for later use;

(3) Stir and mix the yam freeze-dried powder obtained in step (1) and the mixed extract obtained in step (2), the speed of the mixer is 50-75r/min, and the time is 10-15min, to obtain mixture I and set aside;

(4) Add ethanol to the mixture I obtained in step (3) to make the alcohol concentration reach 75%, let it stand for 8-16 hours, filter it, and discharge the impurities, recover the ethanol at a temperature of 40-60°C and a vacuum of 0.58-0.68MPa , concentrated in vacuo until the dry matter reaches 50-70%, and then vacuum-dried at a drying temperature within the range of 40-60°C to obtain a dry extract for subsequent use;

(5) After crushing the dry extract obtained in step (4), add vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, hawthorn extract, American ginseng extract, mannitol, chitosan Sugar, crude polysaccharide, sucralose, and micropowder silica gel are mixed with a mixer to form granules at a speed of 10-15r/min for 6-8min, and the mixed granules are dried at 50-60°C to The water content is between 1-3%, and it is ready for use;

(6) Add carboxymethyl starch sodium and magnesium stearate to the granules obtained in step (5), mix well, and press into tablets to obtain pomegranate yam dispersible tablets.

In the step (1), fresh yams are washed and soaked in 0.1% vitamin C aqueous solution for 20 minutes, and the soaked yams are put into a freeze dryer for freeze drying. First, the freezer is turned on for refrigeration, and frozen to The temperature of the raw material yam was maintained at -26°C for 8 hours, then the vacuum was turned on, and the drying was continued for 2.5 hours when heated to 95°C, and the solid matter obtained by the above-mentioned freeze-drying was pulverized to obtain a yam freeze-dried powder.

In the step (2), take the raw materials red pomegranate peel and honeysuckle, wash them, add 6 times the total weight of the above raw materials in purified water, decoct at 90°C for 2 hours, filter, and add 3 times the amount of filtered medicinal residues Decoct the purified water at 90°C for 1.5h, filter, discharge the filter residue, combine the two filtrates, and concentrate until the specific gravity is 1, add 2‰ of γ-amylase, keep warm at 45°C for 6h, and finally boil After 35 minutes, it was filtered to obtain a mixed extract.

In summary, the present invention has beneficial effects:

The invention has the functions of invigorating the spleen and stopping diarrhea, and is suitable for children with diarrhea.

Detailed ways

The technical solutions obtained in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments obtained in the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

Example 1

A yam dispersible tablet with pomegranate peel, comprising the following ingredients in parts by weight: 100 parts of red pomegranate peel, 100 parts of yam, 80 parts of honeysuckle, 1.75 parts of vitamin C, 0.01 part of vitamin A, 0.15-0.35 parts of zinc gluconate, and microcrystalline cellulose 40 parts, 0.12 parts of hawthorn extract, 0.12 parts of American ginseng extract, 100 parts of mannitol, 1.2 parts of chitosan oligosaccharide, 1.2 parts of crude polysaccharide, 10 parts of sucralose, 10 parts of micropowder silica gel, 3 parts of carboxymethyl cellulose, 55 parts of sodium carboxymethyl starch, 4 parts of magnesium stearate, appropriate amount of purified water, appropriate amount of 75% ethanol.

A preparation method of yam dispersible tablet with pomegranate peel, comprising the following steps:

(1) Take fresh yam and wash it, soak it in 0.1% vitamin C aqueous solution for 15-20 minutes, put the soaked yam into a freeze dryer for freeze drying, first turn on the freezer for refrigeration, and freeze to the temperature of the raw material yam In the range of -20 to -30°C, keep it dry for 8-10 hours, then turn on the vacuum, and heat to 95-100°C, continue to dry for 1-3 hours, and crush the solid matter obtained by the above freeze-drying to obtain Chinese yam Freeze-dried powder, spare;

(2) Wash the raw materials red pomegranate peel and honeysuckle, add 4-5 times the total weight of the above raw materials in purified water, decoct at 90-100°C for 2-2.5 hours, filter, add 2 - 4 times the amount of purified water, decoct in the range of 90-100 °C for 1-1.5 hours, filter, discharge the filter residue, combine the two filtrates, and concentrate until the specific gravity is 1-1.5, add 1-2‰ of γ-starch Enzymes, keep warm at 35-45°C for 5-10 hours, and finally boil for 25-35 minutes before filtering to obtain a mixed extract for later use;

(3) Stir and mix the yam freeze-dried powder obtained in step (1) and the mixed extract obtained in step (2), the speed of the mixer is 50-75r/min, and the time is 10-15min, to obtain mixture I and set aside;

(4) Add ethanol to the mixture I obtained in step (3) to make the alcohol concentration reach 75%, let it stand for 8-16 hours, filter it, and discharge the impurities, recover the ethanol at a temperature of 40-60°C and a vacuum of 0.58-0.68MPa , concentrated in vacuo until the dry matter reaches 50-70%, and then vacuum-dried at a drying temperature within the range of 40-60°C to obtain a dry extract for subsequent use;

(5) After crushing the dry extract obtained in step (4), add vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, hawthorn extract, American ginseng extract, mannitol, chitosan Sugar, crude polysaccharide, sucralose, and micropowder silica gel are mixed with a mixer to form granules at a speed of 10-15r/min for 6-8min, and the mixed granules are dried at 50-60°C to The water content is between 1-3%, and it is ready for use;

(6) Add carboxymethyl starch sodium and magnesium stearate to the granules obtained in step (5), mix well, and press into tablets to obtain pomegranate yam dispersible tablets.

Example 2

A yam dispersible tablet with pomegranate peel, comprising the following ingredients in parts by weight: 200 parts of red pomegranate peel, 200 parts of yam, 100 parts of honeysuckle, 2.75 parts of vitamin C, 0.015 parts of vitamin A, 0.25 parts of zinc gluconate, and 50 parts of microcrystalline cellulose , 0.22 parts of hawthorn extract, 0.22 parts of American ginseng extract, 135 parts of mannitol, 2.2 parts of chitosan oligosaccharide, 2.2 parts of crude polysaccharide, 12.5 parts of sucralose, 30 parts of micropowder silica gel, 4 parts of carboxymethyl cellulose, carboxymethyl cellulose 67.5 parts of starch sodium, 5 parts of magnesium stearate, appropriate amount of purified water, and appropriate amount of 75% ethanol.

A preparation method of yam dispersible tablet with pomegranate peel, comprising the following steps:

(1) Take fresh yam and wash it, soak it in 0.1% vitamin C aqueous solution for 15-20 minutes, put the soaked yam into a freeze dryer for freeze drying, first turn on the freezer for refrigeration, and freeze to the temperature of the raw material yam In the range of -20 to -30°C, keep it dry for 8-10 hours, then turn on the vacuum, and heat to 95-100°C, continue to dry for 1-3 hours, and crush the solid matter obtained by the above freeze-drying to obtain Chinese yam Freeze-dried powder, spare;

(2) Wash the raw materials red pomegranate peel and honeysuckle, add 4-5 times the total weight of the above raw materials in purified water, decoct at 90-100°C for 2-2.5 hours, filter, add 2 - 4 times the amount of purified water, decoct in the range of 90-100 °C for 1-1.5 hours, filter, discharge the filter residue, combine the two filtrates, and concentrate until the specific gravity is 1-1.5, add 1-2‰ of γ-starch Enzymes, keep warm at 35-45°C for 5-10 hours, and finally boil for 25-35 minutes before filtering to obtain a mixed extract for later use;

(3) Stir and mix the yam freeze-dried powder obtained in step (1) and the mixed extract obtained in step (2), the speed of the mixer is 50-75r/min, and the time is 10-15min, to obtain mixture I and set aside;

(4) Add ethanol to the mixture I obtained in step (3) to make the alcohol concentration reach 75%, let it stand for 8-16 hours, filter it, and discharge the impurities, recover the ethanol at a temperature of 40-60°C and a vacuum of 0.58-0.68MPa , concentrated in vacuo until the dry matter reaches 50-70%, and then vacuum-dried at a drying temperature within the range of 40-60°C to obtain a dry extract for subsequent use;

(5) After crushing the dry extract obtained in step (4), add vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, hawthorn extract, American ginseng extract, mannitol, chitosan Sugar, crude polysaccharide, sucralose, and micropowder silica gel are mixed with a mixer to form granules at a speed of 10-15r/min for 6-8min, and the mixed granules are dried at 50-60°C to The water content is between 1-3%, and it is ready for use;

(6) Add carboxymethyl starch sodium and magnesium stearate to the granules obtained in step (5), mix well, and press into tablets to obtain pomegranate yam dispersible tablets.

Example 3

A yam dispersible tablet with pomegranate peel, comprising the following ingredients in parts by weight: 300 parts of red pomegranate peel, 300 parts of Chinese yam, 120 parts of honeysuckle, 3.75 parts of vitamin C, 0.02 parts of vitamin A, 0.35 parts of zinc gluconate, and 60 parts of microcrystalline cellulose , 0.32 parts of hawthorn extract, 0.32 parts of American ginseng extract, 170 parts of mannitol, 3.2 parts of chitosan oligosaccharide, 3.2 parts of crude polysaccharide, 15 parts of sucralose, 50 parts of micronized silica gel, 5 parts of carboxymethyl cellulose, carboxymethyl cellulose 80 parts of starch sodium, 6 parts of magnesium stearate, appropriate amount of purified water, and appropriate amount of 75% ethanol.

A preparation method of yam dispersible tablet with pomegranate peel, comprising the following steps:

(1) Take fresh yam and wash it, soak it in 0.1% vitamin C aqueous solution for 15-20 minutes, put the soaked yam into a freeze dryer for freeze drying, first turn on the freezer for refrigeration, and freeze to the temperature of the raw material yam In the range of -20 to -30°C, keep it dry for 8-10 hours, then turn on the vacuum, and heat to 95-100°C, continue to dry for 1-3 hours, and crush the solid matter obtained by the above freeze-drying to obtain Chinese yam Freeze-dried powder, spare;

(2) Wash the raw materials red pomegranate peel and honeysuckle, add 4-5 times the total weight of the above raw materials in purified water, decoct at 90-100°C for 2-2.5 hours, filter, add 2 - 4 times the amount of purified water, decoct in the range of 90-100 °C for 1-1.5 hours, filter, discharge the filter residue, combine the two filtrates, and concentrate until the specific gravity is 1-1.5, add 1-2‰ of γ-starch Enzymes, keep warm at 35-45°C for 5-10 hours, and finally boil for 25-35 minutes before filtering to obtain a mixed extract for later use;

(3) Stir and mix the yam freeze-dried powder obtained in step (1) and the mixed extract obtained in step (2), the speed of the mixer is 50-75r/min, and the time is 10-15min, to obtain mixture I and set aside;

(4) Add ethanol to the mixture I obtained in step (3) to make the alcohol concentration reach 75%, let it stand for 8-16 hours, filter it, and discharge the impurities, recover the ethanol at a temperature of 40-60°C and a vacuum of 0.58-0.68MPa , concentrated in vacuo until the dry matter reaches 50-70%, and then vacuum-dried at a drying temperature within the range of 40-60°C to obtain a dry extract for subsequent use;

(5) After crushing the dry extract obtained in step (4), add vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, hawthorn extract, American ginseng extract, mannitol, chitosan Sugar, crude polysaccharide, sucralose, and micropowder silica gel are mixed with a mixer to form granules at a speed of 10-15r/min for 6-8min, and the mixed granules are dried at 50-60°C to The water content is between 1-3%, and it is ready for use;

(6) Add carboxymethyl starch sodium and magnesium stearate to the granules obtained in step (5), mix well, and press into tablets to obtain pomegranate yam dispersible tablets.

It will be apparent to those skilled in the art that the invention is not limited to the details of the above-described exemplary embodiments, but that the invention can be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Accordingly, the embodiments should be regarded in all points of view as exemplary and not restrictive, the scope of the invention being defined by the appended claims rather than the foregoing description, and it is therefore intended that the scope of the invention be defined by the appended claims rather than by the foregoing description. All changes within the meaning and range of equivalents of the elements are embraced in the present invention.

In addition, it should be understood that although this specification is described according to implementation modes, not each implementation mode only contains an independent technical solution, and this description in the specification is only for clarity, and those skilled in the art should take the specification as a whole , the technical solutions obtained in the various embodiments can also be properly combined to form other implementations that can be understood by those skilled in the art.

Claims (1)

1. a preparation method of pomegranate peel yam dispersible tablet, is characterized in that: comprise the following steps: (1) Take fresh yam and wash it, soak it in 0.1% vitamin C aqueous solution for 15-20 minutes, put the soaked yam into a freeze dryer for freeze drying, first turn on the freezer for refrigeration, and freeze to the temperature of the raw material yam In the range of -20 to -30°C, keep it dry for 8-10 hours, then turn on the vacuum, and heat to 95-100°C, continue to dry for 1-3 hours, and crush the solid matter obtained by the above freeze-drying to obtain Chinese yam Freeze-dried powder, spare; (2) Wash the raw materials red pomegranate peel and honeysuckle, add 4-5 times the total weight of the above raw materials in purified water, decoct at 90-100°C for 2-2.5 hours, filter, add 2 - 4 times the amount of purified water, decoct in the range of 90-100 °C for 1-1.5 hours, filter, discharge the filter residue, combine the two filtrates, and concentrate until the specific gravity is 1-1.5, add 1-2‰ of γ-starch Enzymes, keep warm at 35-45°C for 5-10 hours, and finally boil for 25-35 minutes before filtering to obtain a mixed extract for later use; (3) Stir and mix the yam freeze-dried powder obtained in step (1) and the mixed extract obtained in step (2), the speed of the mixer is 50-75r/min, and the time is 10-15min, to obtain mixture I and set aside; (4) Add ethanol to the mixture I obtained in step (3) to make the alcohol concentration reach 75%, let it stand for 8-16 hours, filter it, and discharge the impurities, recover the ethanol at a temperature of 40-60°C and a vacuum of 0.58-0.68MPa , concentrated in vacuo until the dry matter reaches 50-70%, and then vacuum-dried at a drying temperature within the range of 40-60°C to obtain a dry extract for subsequent use; (5) After crushing the dry extract obtained in step (4), add vitamin C, vitamin A, zinc gluconate, carboxymethyl cellulose, microcrystalline cellulose, hawthorn extract, American ginseng extract, mannitol, chitosan Sugar, crude polysaccharide, sucralose, and micropowder silica gel are mixed with a mixer to form granules at a speed of 10-15r/min for 6-8min, and the mixed granules are dried at 50-60°C to The water content is between 1-3%, and it is ready for use; (6) Add carboxymethyl starch sodium and magnesium stearate to the granules obtained in step (5), mix well, and press into tablets to obtain pomegranate yam dispersible tablets.