CN103675248B - A kind of biochemistry analyzer and reagent method for refreshing thereof and device - Google Patents
A kind of biochemistry analyzer and reagent method for refreshing thereof and device Download PDFInfo
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- CN103675248B CN103675248B CN201210499036.XA CN201210499036A CN103675248B CN 103675248 B CN103675248 B CN 103675248B CN 201210499036 A CN201210499036 A CN 201210499036A CN 103675248 B CN103675248 B CN 103675248B
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 525
- 238000000034 method Methods 0.000 title claims abstract description 56
- 238000012360 testing method Methods 0.000 claims abstract description 153
- 238000001514 detection method Methods 0.000 claims abstract description 30
- 230000008569 process Effects 0.000 claims description 27
- 230000003993 interaction Effects 0.000 claims description 26
- 238000012545 processing Methods 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 230000008447 perception Effects 0.000 claims description 5
- 239000013589 supplement Substances 0.000 abstract description 12
- 230000007246 mechanism Effects 0.000 description 20
- 239000000523 sample Substances 0.000 description 13
- 238000012806 monitoring device Methods 0.000 description 10
- 230000007812 deficiency Effects 0.000 description 7
- 230000001502 supplementing effect Effects 0.000 description 6
- 230000004044 response Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 238000013102 re-test Methods 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00326—Analysers with modular structure
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N2035/00891—Displaying information to the operator
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Abstract
This application discloses a kind of biochemistry analyzer and reagent method for refreshing thereof and device.This reagent method for refreshing includes below step: receiving margin updates instruction；Update instruction according to surplus and the numerical value needing the residue carrying out the reagent of surplus refreshing can survey number parameter is updated to preset value；After restarting the test that continuation is follow-up, obtain real-time reagent uptake and reagent；The real surplus calculating this reagent according to real-time reagent uptake and reagent can survey number；The residue of this reagent can be surveyed the numerical value of number parameter be updated to the residue of reality and can survey number.Residue can be surveyed after the not enough reagent of number supplements user by biochemistry analyzer disclosed in the present application, directly the residue of reagent can be surveyed number and refresh as preset value, making instrument without i.e. can be at restarting state by first surplus detection, therefore saving the operating time, improve work efficiency.
Description
Technical field
The application relates to a kind of biochemistry analyzer, be specifically related to a kind of biochemistry analyzer and reagent method for refreshing thereof and
Device.
Background technology
At present, along with the extensively application of biochemical instruments and being continuously increased of sample size, for biochemical instruments at a high speed, easy to use,
The requirement of automaticity is more and more higher, reduces the workload of operator with this, improves work efficiency.
During using biochemical instruments, often draw a reagent, i.e. carry out a reagent detection, according to reagent
The residue calculating reagent with each reagent uptake can survey number.Owing to the sample size of test constantly increases, need to enter timely
Row reagent supplements with satisfied test needs.
Current biochemistry analyzer is after user has supplemented reagent, it is necessary to carries out a reagent and refreshes, i.e. needs to use
Family performs reagent detection or instrument performs reagent detection automatically, and in calculating reagent container, the initial residual of reagent can
Survey number, and the residue of reagent can be surveyed number refresh can survey number for initial residual.Only just can continue after carrying out reagent refreshing
Continuous test subsequent project.The advantage of this mode be user can by reagent detection understand reagent truly can survey number,
So that can assessment reagent can be surveyed number and meet the requirement of test, but it is carried out surplus detection and needs the time of a few minutes, user
Have to wait for, reduce testing efficiency.
Summary of the invention
According to the first aspect of the application, the application provides a kind of reagent method for refreshing, including:
Receiving margin updates instruction；
Update instruction according to surplus to be updated to by the numerical value needing the residue carrying out the reagent of surplus refreshing can survey number parameter
Preset value；
After restarting the test that continuation is follow-up, obtain reagent uptake and real-time reagent；
The real surplus calculating this reagent according to reagent uptake and real-time reagent can survey number；
The residue of this reagent can be surveyed the numerical value of number parameter be updated to the residue of reality and can survey number.
According to the second aspect of the application, the application provides a kind of reagent refreshing apparatus, including:
Initial surplus refresh unit, updates instruction for receiving margin, updates instruction according to surplus and needs are carried out surplus
The residue of the reagent refreshed can be surveyed the numerical value of number parameter and be updated to preset value；
Acquiring unit, for after restarting the test that continuation is follow-up, obtains more than reagent uptake and real-time reagent
Amount；
Residue can survey number computing unit, for calculating the reality of this reagent according to reagent uptake and real-time reagent
Residue can survey number；
Surplus updating block in test process, is updated to reality for the residue of this reagent can be surveyed the numerical value of number parameter
Residue can survey number.
According to the third aspect of the application, the application provides a kind of biochemistry analyzer, including:
Man-machine interaction unit, for receiving the input of operator and showing information to operator；
Reagent detection device, for detectable surplus after drawing reagent every time；
Processing and control element (PCE), processing and control element (PCE) includes that Reagent management module, described Reagent management module include
Stating reagent refreshing apparatus, described reagent refreshing apparatus obtains real-time reagent from reagent detection device.
The application, after user supplements reagent, by needing the residue carrying out the reagent of surplus refreshing can survey number refreshing is directly
Preset value, makes biochemistry analyzer can proceed with project testing, detects the reagent of reality, meter subsequently again when drawing reagent
The residue calculating reality can survey number, and guides follow-up detection.Therefore this reagent refresh scheme of the application, is supplementing
It is made without the reagent detection of reality before proceeding project testing after reagent, is equivalent to eliminate a reagent
Detection, therefore saves the operating time, improves work efficiency.
Accompanying drawing explanation
Fig. 1 is the structural representation of the reagent refreshing apparatus of a kind of embodiment of the application；
Fig. 2 is the flow chart of the reagent method for refreshing of a kind of embodiment of the application；
Fig. 3 be a kind of embodiment of the application practical operation in reagent refresh flow chart；
Fig. 4 is the flow chart of the reagent method for refreshing of the application another kind embodiment；
Fig. 5 is the structural representation of the reagent refreshing apparatus of the application another kind embodiment；
Fig. 6 is the flow chart of the reagent method for refreshing of another embodiment of the application；
Fig. 7 is the module diagram of the application a kind of embodiment mesophytization analyser；
Fig. 8 be the application another kind embodiment practical operation in reagent refresh flow chart；
Fig. 9 is the schematic flow sheet that a kind of reagent loads online；
Figure 10 is the schematic flow sheet that another kind of reagent loads online；
Figure 11 is to load the flow chart that after reagent, startup is tested automatically.
Detailed description of the invention
Combine accompanying drawing below by detailed description of the invention the application is described in further detail.
Biochemistry analyzer mainly includes reaction tray mechanism, sample loader mechanism, load reagents mechanism, sample charging mechanism, additional examination
Agent mechanism and master control system (being the most also called for short system).Master control system is for being managed test, calculating and/or analyze survey
Test result and offer human-computer interaction interface etc., master control system includes the input for receiving operator and shows information to operator
Man-machine interaction unit and processing and control element (PCE).Reaction tray mechanism includes the reaction tray for carrying reaction cup, and sample loads
Mechanism is used for providing tested sample, including sample disk or sample conveyer frames, sample charging mechanism according to the management of master control system from sample
Drawing sample in sample cup on this dish or sample conveyer frames, and be filled in reaction cup, load reagents mechanism is used for providing anti-
Application reagent, generally includes reagent disc, and reagent adding mechanism inhales according in the reagent container managed from reagent disc of master control system
Take reagent, and reagent is filled in reaction cup.Reagent adding mechanism includes the reagent pin for drawing reagent, generally, at reagent
Reagent detection device it is additionally provided with, for the reagent of detectable after drawing reagent every time, it is provided that give place on pin
Reason and control unit calculate residue and can survey number.
When reagent deficiency in reagent container, need to carry out reagents loaded, supplement reagent, it is generally the case that work as system
Detect that operator supplements the operation (signal ordered or sent by button such as exported) of reagent at interpersonal interactive interface
Time, time-out is tested, needs to join reagent corresponding with this reagent container in system after supplementing reagent in reagent container
Number performs reagent and refreshes, in the embodiment of the present application, when needs carry out reagent refreshing, according to the behaviour of operator
Making, instrument sends surplus and updates instruction, and processing and control element (PCE) is after receiving margin updates instruction, and updating instruction according to surplus will
The numerical value needing the residue carrying out the reagent (i.e. reagent in reagent container) of surplus refreshing can survey number parameter is updated to preset value,
After renewal, system can restart and proceed follow-up test, then after having performed first time suction reagent, and reagent
The actual surplus of the reagent in test device to test reagent container, and send this actual surplus to processing and control element (PCE), place
Reason and control unit calculate the real surplus of the reagent in this reagent container according to real-time reagent uptake and reagent can
Survey number, and the numerical value that the residue of this reagent can be surveyed number parameter is updated to actual residue and can survey number.Reagent uptake can basis
The detailed programs of test preset, it is possible to detect in real time when inhaling reagent every time.Reagent test device can be liquid level
Detection device, by the liquid level of detectable, thus calculates reagent.Certainly, reagent test device also may be used
Be other detection liquid residue device.
Embodiment one:
In the present embodiment, biochemistry analyzer includes the input for receiving operator and shows the man-machine of information to operator
Interactive unit, reagent detection device and processing and control element (PCE), processing and control element (PCE) includes Reagent management module, reagent
Management module is used for gathering reagent information and management reagent information, and user can also be reminded in some instantiation to carry out reagent
Load.In the present embodiment, Reagent management module includes reagent refreshing apparatus, as it is shown in figure 1, reagent refreshing apparatus 10
Surplus in number computing unit 15 and test process can be surveyed update single including initial surplus refresh unit 11, acquiring unit 13, residue
Unit 17.Initial surplus refresh unit 11 updates instruction for receiving margin, updates instruction according to surplus and needs are carried out surplus brush
The residue of new reagent can be surveyed the numerical value of number parameter and be updated to preset value.Acquiring unit 13 is for restart continuation follow-up
After test, obtain reagent uptake and real-time reagent.Residue can survey number computing unit 15 for according to reagent uptake
The real surplus calculating this reagent with real-time reagent can survey number.In test process, surplus updating block 17 is for by this examination
The residue of agent can be surveyed the numerical value of number parameter and be updated to the residue of reality and can survey number.
Based on above-mentioned reagent refreshing apparatus, in one embodiment, reagent method for refreshing as in figure 2 it is shown,
Comprise the following steps:
Step 101a, receiving margin updates instruction.In the present embodiment, surplus updates instruction and passes through man-machine interaction for operator
The order of interface input, such as operator inputs reagent identification information of supplementing, then in the input window of human-computer interaction interface
Selecting surplus to update icon, human-computer interaction interface generates surplus and updates instruction, and this instruction includes that being performed reagent updates
The identification information of reagent, identification information can be the title of reagent, bottle number, lot number or the reagent accommodating this reagent
One or more in the location number that container is placed, may determine that in system it is which or which reagent by this identification information
Need to perform surplus to update.Certainly, operator can not also input supplementary reagent in the input window of human-computer interaction interface
Identification information, but directly select surplus update icon, now human-computer interaction interface generate surplus update instruction in does not wraps
Include the identification information being performed the reagent container that reagent updates.
Step 102a, updates, according to surplus, the number that instruction will need the residue carrying out the reagent of surplus refreshing can survey number parameter
Value is updated to preset value, and this preset value can be arbitrary value, such as, can be a fixed value or infinity.In surplus renewal process
In, if surplus updates instruction and includes the identification information of reagent, then the residue by the reagent corresponding with reagent identification information can
The numerical value surveying number parameter is updated to preset value.If surplus updates in instruction does not include reagent identification information, then by all of examination
The residue of agent can be surveyed the numerical value of number parameter and be updated to preset value.
Step 103a, when detecting that residue can be surveyed after number parameter is refreshed, instrument proceeds to restart to carry out follow-up
The state of test, after restarting and continuing follow-up test, obtains reagent uptake and real-time reagent.
Step 104a, the real surplus calculating this reagent according to reagent uptake and real-time reagent can survey number.
Step 105a, can survey the residue of this reagent the numerical value of number parameter and be updated to the residue of reality and can survey number.
Generally, in test process can the surplus of real-time detectable, and calculate real-time residue and can survey number, prompting is used
Family reagent is the most not enough.A kind of concrete operational approach of biochemistry analyzer is described below, as it is shown on figure 3, include below step:
Step 101b, detecting current reagent residue, can to survey number the most sufficient, if sufficient, then forwards step 105b to, continues
Test；If not enough, then forward step 102b to.In an instantiation, whether detecting current reagent residue, can to survey number sufficient
Method may is that can be surveyed current residual number and set threshold ratio relatively, if current residual can survey number more than or equal to this setting
Threshold value, then explanation current residual can survey number abundance；If current residual can be surveyed number and be less than this setting threshold value, then current residual is described
Number can be surveyed not enough, need reagent is supplemented.Instrument in the course of the work, can be constantly according to the reagent in each project testing
Uptake and level detection height, the reagent residue calculating each project can survey number.When reagent residue can survey number abundance, instrument
Device can continue following project testing, and when reagent residue can survey number deficiency, instrument needs information notice not enough for reagent
To user, such as, the information that reagent is not enough is shown on the display device or lights the display lamp representing that reagent is not enough, instrument
Following project testing can be continued after supplementary reagent.
Step 102b, after detecting that reagent residue can survey the information that number is not enough, human-computer interaction interface be given warning or
Prompting, waits that corresponding reagent is supplemented by user.
Step 103b, suspends at instrument, and during carrying out reagent supplementing and/or after supplementary reagent, instrument is not
Disconnected detection surplus updates instruction, without detecting that surplus updates instruction, then forwards step 102b to and continues waiting for；If detection
Update instruction to surplus, then forward step 104b to.
Step 104b, the residue of all reagent can be surveyed number refreshing is a preset value or will be corresponding with reagent identification information
The residue of reagent can survey the numerical value of number parameter and be updated to preset value, this preset value is pre-set by user, such as, can preset
Value is set to one and represents that current reagent is sufficient, is in the value of upstate.In an instantiation, preset value can set
The maximum residual being set to infinity or reagent container full load reagent can survey number.
Step 105b, instrument detects that residue can be surveyed after number parameter is refreshed, it is believed that the residue of reagent can survey that number is in can
When using state, proceed to restart state.
The reagent method for refreshing that the present embodiment provides, can survey after the not enough reagent of number supplements user, directly to residue
Connect and refresh needing the residue carrying out the reagent of surplus refreshing can survey number as preset value, it is not necessary to carry out reagent before restart
Surplus detection can make instrument enter can continue test mode, therefore saves the operating time, improves work efficiency.
Embodiment two:
When not including reagent identification information during surplus updates instruction, the present embodiment provides another kind of reagent
Method for refreshing, it is not necessary to the numerical value that the residue of all of reagent can survey number parameter is updated to preset value.
Refer to Fig. 4, the another kind of reagent method for refreshing that the present embodiment provides, including below step:
Step 201, receiving margin updates instruction.In the present embodiment, surplus updates instruction and passes through man-machine interaction for operator
The order of interface input, operator does not input the identification information of supplementary reagent in the input window of human-computer interaction interface, but
Directly selecting surplus and update icon, the surplus that now human-computer interaction interface generates updates in instruction and does not include being performed reagent
The reagent identification information updated.
Step 202, obtains all reagent reagent residue before supplementary reagent and can survey number.
Step 203, can survey number by the reagent residue before supplementary reagent and compare with frequency threshold value N, according to compare
Result determines whether that the numerical value that the residue of reagent can be surveyed number parameter is updated to preset value.Reagent residue before supplementary reagent
When can survey number more than or equal to frequency threshold value N, perform step 204, otherwise, perform step 205.Frequency threshold value is for being used for judging examination
The residue of agent can survey the predetermined threshold value that number is the most not enough, and frequency threshold value can be pre-set by user, and different test event
Frequency threshold value can be different, and corresponding frequency threshold value N of each reagent compares.
Step 204, the reagent residue before supplementary reagent being detected in step 203 can survey number when reaching frequency threshold value N,
The residue to reagent can not surveyed number and refreshes.
Step 205, the reagent residue before being judged as supplementary reagent in step 203 can be surveyed number and be not reaching to number of times threshold
It is a preset value that the residue of the reagent of value N can survey number to refresh, and this preset value is pre-set by user, and preset value represents current examination
Agent surplus is sufficient, is in upstate.Such as, preset value could be arranged to infinity or reagent container full load reagent
Big residue can survey number.In the present embodiment, preset value is set greater than the value of frequency threshold value N.
At instrument, step 206, detects that residue can be surveyed after number parameter is refreshed, it is believed that reagent residue can be surveyed number and be in available
During state, proceed to restart and proceed the state of subsequent project test.Such as: it is pre-that reagent residue can survey number to refresh
If after Zhi, instrument soon restarts test.
Step 207, after instrument restarts and carries out drawing reagent for the first time, obtains level detection height now.
Step 208, can survey number according to the real surplus of reagent uptake and each reagent of level detection high computational.
Step 209, the real surplus that the numerical value refreshing that current residual can be surveyed number is reagent can survey number.
The reagent method for refreshing that the present embodiment provides can be distinguished and whether reaches the residue of frequency threshold value and can survey number, only
The reagent residue being not reaching to frequency threshold value can be surveyed number refresh, improve the accuracy that surplus refreshes, reduce not simultaneously
Necessary refresh operation, can be time-consuming.The present embodiment provide reagent method for refreshing to residue can survey number refresh after,
During project testing, calculate the real surplus of reagent can survey number, and current residual can be surveyed that number refreshes can for real surplus
Survey number, it is ensured that data preparatory.
Embodiment three:
When not including reagent identification information during surplus updates instruction, the present embodiment provides another reagent
Method for refreshing, it is not necessary to the numerical value that the residue of all of reagent can survey number parameter is updated to preset value.
Refer to Fig. 5, in the present embodiment, reagent refreshing apparatus 10 includes comparing unit 12, record unit 14, initial
Surplus refresh unit 11, acquiring unit 13, residue can survey surplus updating block 17 in number computing unit 15 and test process.Relatively
Unit 12 compares with frequency threshold value for current residual being surveyed number in test process, records unit 14 and is used for recording surplus
Remaining can survey the number identification information less than the reagent of frequency threshold value.After instrument time-out carries out load reagents, initial surplus refreshes single
The residue of the reagent corresponding with reagent identification information, after receiving surplus renewal instruction, can be surveyed the numerical value of number parameter more by unit 11
New is preset value.Acquiring unit 13, after restarting and continuing follow-up test, obtains real-time reagent uptake and reagent
Surplus.Residue can be surveyed number computing unit 15 and then calculate the real surplus of this reagent according to real-time reagent uptake and reagent
Number can be surveyed.In test process, the residue of this reagent can be surveyed the numerical value of number parameter and be updated to the residue of reality by surplus updating block 17
Number can be surveyed.
The present embodiment provide reagent method for refreshing as shown in Figure 6, including below step:
Step 301, detecting current reagent residue, can to survey number the most sufficient, if sufficient, then forwards step 306 to, continues to open
Dynamic test；If not enough, then forward step 302 to.In an instantiation, whether detecting current reagent residue, can to survey number sufficient
Method may is that can be surveyed current residual number and set threshold ratio relatively, and this setting threshold value can be identical with frequency threshold value N, it is possible to
With difference.If current residual can survey number is more than or equal to this setting threshold value, then explanation current residual can survey number abundance；If worked as
Front residue can be surveyed number and be less than this setting threshold value, then explanation current residual can survey number deficiency, needs to supplement reagent.Instrument exists
In work process, each project can be calculated constantly according to the reagent uptake in each project testing and level detection height
Reagent residue can survey number.When reagent residue can survey number abundance, instrument can continue following project testing, when reagent remains
When can survey number deficiency, instrument needs the information by reagent is not enough to notify to user, such as, shows the information that reagent is not enough aobvious
Show on equipment or light the display lamp representing that reagent is not enough.
Step 302, record detects that residue can survey the identification information of the not enough reagent of number in step 301.
Step 303, after detecting that reagent residue can survey the information that number is not enough, prompting user supplements reagent, when user is true
During reagent to be supplemented, by user operation, instrument enters reagents loaded state, waits that user supplements reagent.
Step 304, instrument constantly detects whether to receive remaining during waiting user's time-out of supplementing reagent
Amount updates instruction, without detecting that surplus updates instruction, then continues waiting for surplus and updates instruction；If be detected that surplus is more
New instruction, illustrates that the reagent that residue can be surveyed number not enough by user has been carried out supplementing, and needs the reagent being added is performed surplus
Refresh operation, forwards step 305 to.
Step 305, after step 304 detects that surplus updates instruction, the reagent identification information according to step 302 record will
It is a preset value that the residue of corresponding reagent can survey number to refresh.
At instrument, step 306, detects that reagent residue can be surveyed after number refreshes, proceed to can to restart and continue follow-up
The state of project testing.
Step 307, carries out inhaling reagent operation for the first time after restarting, obtains in real time after inhaling reagent operation for the first time
Level detection height.
Step 308, according to reagent uptake and the real surplus of the real-time each test event of level detection high computational
Number can be surveyed.
Step 309, the real surplus that the numerical value refreshing that current residual can be surveyed number is reagent can survey number.
The present embodiment records the identification information of the not enough reagent of surplus in test process, only residue can be surveyed number and be detected as
Not enough reagent carries out surplus refresh operation, not only increases the accuracy that surplus refreshes, and also reduces unnecessary data simultaneously
Process, can time-consuming and system resources consumption.
Embodiment four:
Refer to Fig. 7, in the present embodiment, biochemistry analyzer 400 includes reagent disk cover monitoring device 410, load reagents machine
Structure 420, for drawing reagent the reagent adding mechanism 440 being filled into reaction cup, processing and control element (PCE) 430 from reagent disc,
Load reagents mechanism 420 includes reagent disc and covers the reagent disk cover (not shown) on reagent disc, and reagent disc is driving
Under the drive of device rotatably.In test process, reagent disk cover is closure state, and reagent disc will under the drive of driving means
Predetermined reagent container turns to inhale reagent position, and reagent adding mechanism the most also drives reagent pin to rotate, and completes reagent adding operation.Examination
For opening to produce when reagent disc maybe will open reagent disc in test process, agent disk cover monitoring device represents that reagent disk cover is beaten
The signal opened, when processing and control element (PCE) 430 receives this signal, carries out respective handling, enabled to reagent
Traditional thread binding load.In a kind of instantiation, processing and control element (PCE) 430 include instrument management module 431, test and management module 433,
Test module 432 and Reagent management module 435.The action of each parts of instrument management module 431 detection instrument or state, including examination
Agent disk cover opens or closes information, and performs corresponding instrument action, supports load reagents or test.Reagent management module 435
For gathering reagent information and management reagent information, user can also be reminded in some instantiation to carry out load reagents.Survey
Test tube reason module 433, for needing the test carried out to be managed, generating test information, can not proceed including cancelling
Test, retests automatically.Test module 432 is for testing according to the test information of test and management module.
In a kind of instantiation, reagent disk cover monitoring device 410 produces the first triggering letter representing that reagent disk cover is opened
Number, instrument management module 431 triggers signal according to first and sends protection of instrumentation order, and protection of instrumentation order is for controlling and first
The reagent disc triggering signal corresponding stops operating, and drives the reagent pin corresponding with reagent disc to stop with controlling reagent adding mechanism 440
To home, Reagent management module 435 for according to first trigger signal enter can the state of loaded reagent, can loaded reagent
State be the state allowing more novel agent raw information, reagent raw information such as includes the position of reagent, lot number, project etc.
Information.
In another kind of specific embodiment, test and management module 433 triggers what signal judgement can proceed with according to first
Test event and need cancel test event, the test event that can proceed be completed with first trigger signal corresponding
The test event of the reagent adding of reagent disc, needs the test item that test event is the reagent adding being not fully complete this reagent disc cancelled
Mesh.Test and management module 433 generates test information according to judged result.Test module 432 generates according to test and management module 433
Test information test, such as generate test control signal or generate measuring and calculation result, test control signal can be used for
Control sample charging mechanism and perform sample-adding operation, the execution reagent adding operation of reagent adding mechanism etc..
In still another embodiment, reagent disk cover monitoring device 410 is additionally operable to produce represent that reagent disk cover is closed the
Two trigger signal, and instrument management module 431 triggers signal according to second and confirms to have triggered reagent disk cover corresponding to signal with second
Through closing, detect current all reagent disc disk covers the most all already at closed mode, if it is start instrument recovery flow process.
Instrument recovers flow process and includes: reagent disc and reagent adding mechanism return to initial position, prepares to start according to proper testing flow process
Start new test.The notice starting newly to test is produced when instrument recovers instrument management module after flow process completes.Test and management mould
Block 433 restarts test automatically according to the notice starting new test, it would be desirable to the new test event carrying out testing needs after cancelling
The project of resurveying retested generates test information according to testing sequence.Test module 432 generates according to test and management module 433
Test information test.
In the present embodiment, signal can be triggered second and try after closing as surplus renewal instruction, i.e. reagent disk cover
Agent surplus refreshes.Owing to the second triggering signal not including the identification information of reagent, therefore can when carrying out reagent and refreshing
Use the scheme of embodiment two or three, or the residue of all of reagent can be surveyed number be all updated to preset value.Refer to Fig. 8,
Fig. 8 show a kind of user and knows that reagent is not enough, and changes or embodiment that after supplementary reagent, reagent refreshes, including with
Lower step:
Step S1, in test process, Reagent management module is for the level detection according to each reagent uptake Yu reagent
Highly, the reagent residue calculating each project can survey number.
Step S2, when user needs to check Reagent management module, Reagent management module receives user and passes through man-machine interaction
The viewing command of interface input, is shown to user by the reagent to be supplemented that reagent residue can survey number not enough.User remains according to reagent
Remaining number information of can surveying determines whether to perform load reagents.
Step S3, can survey, for residue, the reagent that number is sufficient, and user can directly apply for test information.
Step S4, can survey, for residue, the reagent that number is not enough, and user needs to open reagent disk cover, produces and represents reagent disk cover
The the first triggering signal opened, system triggers signal in response to first, is managed reagent on-line loaded, makes the user can safety
Supplement deficiency reagent.
First generation triggering signal can be user when opening reagent disk cover by being arranged on reagent disc or reagent disc lid
Sensor produce, it is also possible to by trigger button or click on the option on human-computer interaction interface and produce.First triggers signal
Can also produce in the following manner: Reagent management module 435 visualizingre agent information, remind user to carry out load reagents, user
Determining according to this prompting and require supplementation with reagent, then user is by opening reagent disk cover, trigger button or clicking on man-machine interaction circle
Option on face and trigger the first triggering signal and produce.Therefore, when the first triggering signal produces, reagent disk cover may be beaten
Open, it is also possible to have already turned on and maybe will open.
Step S5, after user has supplemented reagent, shuts reagent disk cover, produces the second triggering letter representing that reagent disk cover is closed
Number.
Second generation triggering signal can be by being arranged on reagent disc or reagent disk cover when user closes reagent disk cover
On sensor produce, it is also possible to by trigger button or click on the option on human-computer interaction interface and produce.Second triggers letter
Number produce time, reagent disk cover may be closed, it is also possible to has been switched off maybe will closing.
Step S6, after system detects that reagent disk cover is closed, the second triggering signal closed according to reagent disk cover, by each survey
The reagent residue of examination project can survey number and frequency threshold value N compares judgement, and N is the integer more than 0, and N can be set by user oneself
Putting, the N value of disparity items can be different.It is the numerical value before reagent supplements that residue herein can survey number, i.e. carries out surplus and refreshes it
Front numerical value.
Step S7, if the residue of project can be surveyed number≤N, i.e. system and think that user has changed or supplemented surplus deficiency
Reagent, supplementary reagent can support follow-up test.Therefore system automatically refreshes the residue of these reagent and can survey number for infinity,
I.e. system thinks that the reagent of this project is sufficient.
Step S8, if the surplus of project can survey number > N, it is constant that system keeps the surplus of these projects can survey number, i.e. system
Think that the reagent of this project does not supplement, number can be surveyed with last reagent consistent.
In above-mentioned steps, in step s 4, which reagent is Reagent management module can also go out according to the threshold decision set
Surplus is not enough, in step S6-8, after detecting the second triggering signal that reagent disk cover is closed, will be judged in step s 4
Surplus renewal is carried out for surplus deficiency reagent.
In another instantiation, system carries out the opportunity of reagent refreshing, can not only close after reagent disk cover,
System may specify that other opportunitys refresh reagent automatically, to support follow-up test.Such as according to the surplus of operator's input
The surplus of the reagent corresponding with reagent identification information can be surveyed the numerical value of number parameter and be updated by renewal instruction；Or at scanner
The numerical value that the surplus of the reagent corresponding with reagent identification information can be surveyed after supplementary reagent scanning reagent information number parameter is entered
Row updates.Under this update mode, the reagent before supplementary reagent can be surveyed number and compare can prevent with frequency threshold value N
The erroneous input of user, to reduce data processing amount.Under this update mode, it is also possible to the reagent before need not supplementary reagent
Surplus can be surveyed number and compare with frequency threshold value N.
When the numerical value that surplus can be surveyed number parameter is updated, the numerical value that surplus can be surveyed number parameter is updated to one
Individual preset value, preset value may be greater than the value of certain number, and preset value can also be infinitely great, and now on interface, surplus can be surveyed
Digital display is shown as empty.
In another instantiation, the surplus of all loaded reagent, the number that surplus can not can be surveyed number is sentenced
Disconnected, i.e. all automatically refresh reagent, to support follow-up test after having loaded reagent.
The present embodiment is after user has supplemented reagent, and it is available that system can residue can be surveyed number not enough reagent automatically refresh
State, accordingly even when do not perform surplus detection, system also is able to support the follow-on test of this project reagent.
In step s 4, system triggers signal in response to first, a kind of concrete side being managed reagent on-line loaded
Method is as it is shown in figure 9, comprise the following steps:
S11: produce the first triggering signal representing that reagent disk cover is opened.Reagent disc can have one or more, accordingly,
Reagent disk cover can also have one or more, and at test process, operator is according to the needs of supplementary reagent, it is possible to opens arbitrarily
Individual reagent disk cover.When certain reagent disk cover is opened and maybe will be opened, reagent disk cover monitoring device 410 produces the first triggering letter
Number, first triggers signal is used for representing that reagent disk cover is opened.
In a kind of instantiation, reagent disk cover monitoring device 410 can be provided on reagent disc or reagent disc lid using
In the sensor of perception reagent disk cover folding, when reagent disk cover is opened or closed, sensor information changes, output difference
Signal, when reagent disk cover is opened, sensor output first triggering signal.Sensor for perception reagent disk cover folding can
Use any sensor of realized perception reagent disk cover folding that is existing or that occur in the future.In another kind of instantiation, examination
Agent disk cover monitoring device 410 can also is that the button being connected with processing and control element (PCE), and button may be provided at biochemistry analyzer
Optional position, is preferably provided at user-friendly position.When user presses this button, represent reagent disk cover opened or
Opening and maybe will open.In another instantiation, reagent disk cover monitoring device 410 can also is that man-machine interaction circle
Face, user, by the option arranged on human-computer interaction interface, can input order by click option, produces the first triggering signal.
S12: processing and control element (PCE) receives the first triggering signal, and instrument management module triggers signal according to first and sends instrument
Device guarded command, and perform following control according to protection of instrumentation order.
S131: the reagent disc controlling to trigger signal corresponding with first stops operating, load reagents mechanism responds this control life
Order, driving means controls reagent disc and stops operating.
S132: the reagent pin controlling this reagent disc corresponding stops to home.Reagent adding mechanism orders according to protection of instrumentation
Order drives reagent pin to stop to home.
Home can be any position not hindering reagent disc to open and load reagent, such as, in vertical direction
Leave reagent disc and have a position of certain altitude, or leave reagent disc in the horizontal direction and have the position of certain distance.Concrete one
In example, home can be the position that reagent pin elder generation vertical ascent horizontally rotates to leave reagent disc certain distance again, example
As, reagent pin location when instrument stops.
S133: controlling that instrument enters can the state of loaded reagent.Such as, triggering signal according to first makes biochemistry analyzer enter
Enter can the state of loaded reagent, in this state, reagent raw information can be allowed to be updated.After operator have loaded reagent,
According to the difference of reagent raw information update mode, human-computer interaction interface can be passed through by defeated for reagent raw information by operator
Enter, it is also possible to reagent raw information is inputted by the bar code of the new reagent container loaded of scanning by scanner.The present embodiment
In, processing and control element (PCE) sends protection of instrumentation order by response the first triggering signal, thus carries out safeguard protection, safety
Protection includes the safety of instrument and the safety of operator.Reagent disc is not rotated further by when reagent disk cover is opened, so can be pre-
Anti-tamper reagent container or impact operations personnel, reagent pin stops to home preventing instrument impact operations personnel, and is
Operator's loaded reagent reserves working place.
Safety protection control order to reagent disc and reagent pin can be simultaneously emitted by also can in succession sending.Above-mentioned steps
The sequential of S132 and S133 can be exchanged.
In step s 4, system triggers signal in response to first, and be managed reagent on-line loaded is another kind of concrete
Method as shown in Figure 10, comprises the following steps:
S21: produce the first triggering signal representing that reagent disk cover is opened.
S22: processing and control element (PCE) receives the first triggering signal, and test and management module triggers signal to needs according to first
The test carried out carries out test and management.It can be directly the first triggering letter that the reagent disc that test and management module receives opens information
Number, it is also possible to it is the first triggering signal after instrument management module forwards or process.
S23: judge the type of test event.Test and management module is according to currently testing situation about carrying out, it is judged that reagent disc
In lid opening process, execution guarded command is for having started to the impact of test, and the project having started to test is divided into two classes,
The test event that the test event proceeded and needs cancel.The test event that wherein can proceed with is for completing corresponding reagent
The test of the reagent adding of dish, do not opened the test event affected by reagent disk cover；Need the test event cancelled for being not fully complete
The test tested and be interrupted of the reagent adding of corresponding reagent dish.If the test event proceeded, then go to step S24,
If needing the test event cancelled, go to step S25.
S24: test module proceeds test to the test event that can proceed with, test provides test knot after terminating
Really.
S25: test and management module, by needing the test event cancelled to perform operation of cancelling, does not continues to perform.
The test event of calcellation is generated the project of resurveying needing to retest by S26: test and management module, waits to start again at
Resurvey during test.
The present embodiment is classified management after receiving the first triggering signal to the test event having started to, and makes not to be subject to
The test event of the impact that reagent disk cover is opened can proceed with test, affected test event is cancelled, and does not continues to survey
Examination, in order to avoid causing error result.So that reagent disk cover can be the most errorless by test after directly opening carrying out.
In another instantiation, system is additionally in response to the second triggering signal to be made instrument automatically start and restarts to survey
Examination.
Refer to Figure 11, make the automatically actuated method of instrument comprise the steps:
S31: produce the second triggering signal representing that reagent disk cover is closed.When load reagents is complete, when reagent disk cover is closed
When maybe will close, reagent disk cover monitoring device 410 produces the second triggering signal representing that reagent disk cover is closed.With reagent disk cover
Monitoring device 410 is to be arranged on reagent disc or reagent disc lid as a example by the sensor of perception reagent disk cover folding, works as reagent
When disk cover is closed, sensor information changes, output the second triggering signal.
S32: processing and control element (PCE) receives the second triggering signal, and instrument management module triggers signal pair according to second
The reagent disc answered carries out confirming operation, confirms that operation can include validating that the corresponding reagent information of current reagent disc the most more
Newly, it is also possible to include validating that whether the reagent disk cover triggering signal corresponding with second has been switched off, without updating then basis
The reagent information gathered is updated, and such as prompting operator input reagent raw information, or control scanner scanning is filled
The reagent container carried.
S33: the instrument management module current all reagent disk covers of detection the most in closed mode, the most then turn step
Rapid S341, if it is not, then go to step S342；
S341: instrument management module starts instrument and recovers flow process.Instrument management module check is to all reagent disc disk covers
In time closing, then start instrument and recover flow process, reagent disc and reagent pipetting volume unit are returned to initial position, prepare to start according to
The test that proper testing flow startup is new.After having recovered, perform step S35；
S342: continue waiting for the second triggering signal corresponding with the reagent disk cover being not turned off, go to step S33；In this step,
After processing and control element (PCE) receives the second triggering signal corresponding with the reagent disk cover being not turned off, return again step S33, then
The current all reagent disk covers of secondary detection, whether all in closed state, if also reagent disc is not turned off, then perform step
S342, continues waiting for, until confirming that all of reagent disk cover goes to step S341 after being all turned off again.
S35: instrument management module produces the notice starting new test, and sends a notice to test and management module.
S36: test and management module restarts test automatically according to the notice starting new test, and management needs the new test started
With cancel and need to carry out the test resurveyed because opening reagent disc, and to needing the test carried out to be ranked up according to testing sequence,
The new test event carrying out needs testing generates test information with project of resurveying according to testing sequence.
S37: the test information that test module gives according to test and management module, tests according to testing process, and
Provide the test result of all tests eventually.
Above content is to combine the further description that the application is made by specific embodiment, it is impossible to assert this Shen
Being embodied as please is confined to these explanations.For the application person of an ordinary skill in the technical field, do not taking off
On the premise of the application conceives, it is also possible to make some simple deduction or replace.
Claims (13)
1. a biochemistry analyzer reagent method for refreshing, it is characterised in that including:
Receiving margin updates instruction；
Update instruction according to surplus to be updated to preset by the numerical value needing the residue carrying out the reagent of surplus refreshing can survey number parameter
Value；
After restarting the test that continuation is follow-up, obtain reagent uptake and real-time reagent；
The real surplus calculating this reagent according to reagent uptake and real-time reagent can survey number；
The residue of this reagent can be surveyed the numerical value of number parameter be updated to the residue of reality and can survey number.
2. the method for claim 1, it is characterised in that described surplus updates instruction for operator by man-machine interaction circle
The order of face input, described surplus updates instruction and includes being performed the identification information of the reagent that reagent updates, described
Update instruction according to surplus and the numerical value needing the residue carrying out the reagent of surplus refreshing can survey number parameter is updated to preset value
The numerical value that the residue of the reagent corresponding with identification information can be surveyed in step number parameter is updated to preset value.
3. the method for claim 1, it is characterised in that described surplus updates instruction for being used for representing that reagent disk cover is closed
The second triggering signal or order of inputting by human-computer interaction interface for operator, instruct need according to surplus renewal described
The residue of the reagent of surplus refreshing to be carried out can be surveyed the numerical value of number parameter and be updated to all of reagent in the step of preset value
Residue can be surveyed the numerical value of number parameter and be updated to preset value.
4. the method for claim 1, it is characterised in that described surplus updates instruction for being used for representing that reagent disk cover is closed
The second triggering signal, or the order inputted by human-computer interaction interface for operator, instruct general described update according to surplus
The numerical value needing the residue carrying out the reagent of surplus refreshing can survey number parameter is updated to the step of preset value and includes:
Obtain all reagent reagent residue before supplementary reagent and can survey number；
Reagent residue before supplementary reagent can be surveyed number compare with frequency threshold value, described frequency threshold value is for being used for judging examination
The residue of agent can survey the predetermined threshold value that number is the most not enough；
Determine whether that the numerical value that the residue of reagent can be surveyed number parameter is updated to preset value according to result of the comparison.
5. reagent method for refreshing as claimed in claim 4, it is characterised in that described second triggers signal by being arranged on examination
The sensor being used for perception reagent container lid folding on agent container or reagent container lid or the button being connected with master control system produce.
6. the method for claim 1, it is characterised in that also include, can survey number with secondary in test process by current residual
Number threshold value compares, and record residue can survey the number identification information less than the reagent of frequency threshold value, refers to receiving surplus renewal
After order, update at the described numerical value that the residue carrying out the reagent of surplus refreshing will be needed can to survey number parameter according to surplus renewal instruction
For in preset value step, the numerical value that the residue of the reagent corresponding with identification information can survey number parameter is updated to preset value.
7. the method as according to any one of claim 1 to 6, it is characterised in that described preset value is more than frequency threshold value
Fixed value or infinity.
8. a biochemistry analyzer reagent refreshing apparatus, it is characterised in that including:
Initial surplus refresh unit, updates instruction for receiving margin, updates instruction according to surplus and needs are carried out surplus refreshing
The residue of reagent can survey the numerical value of number parameter and be updated to preset value；
Acquiring unit, for after restarting the test that continuation is follow-up, obtains reagent uptake and real-time reagent；
Residue can survey number computing unit, for calculating the real surplus of this reagent according to reagent uptake and real-time reagent
Number can be surveyed；
Surplus updating block in test process, is updated to the residue of reality for the residue of this reagent can be surveyed the numerical value of number parameter
Number can be surveyed.
9. device as claimed in claim 8, it is characterised in that described surplus updates instruction for operator by man-machine interaction circle
The order of face input, described surplus updates instruction and includes being performed the identification information of the reagent that reagent updates, described at the beginning of
The numerical value that the residue of the reagent corresponding with identification information can survey number parameter is updated to preset value by beginning surplus refresh unit.
10. device as claimed in claim 8, it is characterised in that described surplus updates instruction for being used for representing that reagent disk cover closes
The the second triggering signal closed or the order inputted by human-computer interaction interface for operator, described initial surplus refresh unit is by institute
The residue of some reagent can be surveyed the numerical value of number parameter and be updated to preset value.
11. devices as claimed in claim 8, it is characterised in that described surplus updates instruction for being used for representing that reagent disk cover closes
The the second triggering signal closed or the order inputted by human-computer interaction interface for operator, described initial surplus refresh unit obtains
All reagent reagent residue before supplementary reagent can survey number, is remained by the reagent before supplementary reagent and can survey number and number of times threshold
Value compares, and the numerical value that the residue of the reagent less than frequency threshold value can survey number parameter is updated to preset value.
12. devices as claimed in claim 8, it is characterised in that also include, for can survey current residual in test process
The comparing unit that number compares with frequency threshold value, can survey the number identification information less than the reagent of frequency threshold value for recording residue
Record unit, described initial surplus refresh unit is receiving after surplus updates instruction, by with reagent corresponding to the information of identification
Residue can survey the numerical value of number parameter and be updated to preset value.
13. 1 kinds of biochemistry analyzer, it is characterised in that including:
Man-machine interaction unit, for receiving the input of operator and showing information to operator；
Reagent detection device, for detectable surplus after drawing reagent every time；
Processing and control element (PCE), processing and control element (PCE) includes that Reagent management module, described Reagent management module include such as right
Requiring the reagent refreshing apparatus according to any one of 8-12, described reagent refreshing apparatus detects device from reagent
Obtain real-time reagent.
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| CN201210499036.XA CN103675248B (en) | 2012-09-21 | 2012-11-29 | A kind of biochemistry analyzer and reagent method for refreshing thereof and device |
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| CN201210499036.XA CN103675248B (en) | 2012-09-21 | 2012-11-29 | A kind of biochemistry analyzer and reagent method for refreshing thereof and device |
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| CN107367766B (en) * | 2016-05-13 | 2020-12-15 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid amount monitoring device and method for sample analyzer |
| CN107608401B (en) * | 2017-08-31 | 2020-10-09 | 迈克医疗电子有限公司 | Liquid taking method and device |
| CN107703319A (en) * | 2017-09-30 | 2018-02-16 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent management method and device, Biochemical Analyzer, the storage medium of Biochemical Analyzer |
| CN107782675A (en) * | 2017-09-30 | 2018-03-09 | 深圳迈瑞生物医疗电子股份有限公司 | A kind of consumable information processing method and biological sample analysis instrument |
| CN110133307B (en) * | 2018-02-08 | 2024-03-12 | 成都深迈瑞医疗电子技术研究院有限公司 | Sample analyzer and control method thereof |
| CN111239429A (en) * | 2018-11-29 | 2020-06-05 | 深圳迈瑞生物医疗电子股份有限公司 | In-vitro diagnostic apparatus, reagent management device and method for replacing reagent |
| CN111929452B (en) * | 2019-05-13 | 2023-01-17 | 深圳市帝迈生物技术有限公司 | Sample detection device, reagent replacement method thereof and computer storage medium |
| CN113924496A (en) * | 2019-06-14 | 2022-01-11 | 利拉伐控股有限公司 | Insertable control unit and liquid container for milk analysis equipment |
| CN110501511B (en) * | 2019-08-13 | 2023-08-08 | 迈克医疗电子有限公司 | Online reagent adjusting method, device and analysis and detection system |
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| CN112964886B (en) * | 2019-12-13 | 2024-02-23 | 深圳迈瑞生物医疗电子股份有限公司 | Analyzer control method, analyzer system, and computer-readable storage medium |
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