CN103656782B - For monitoring the method and apparatus of the infusion of novopen - Google Patents
For monitoring the method and apparatus of the infusion of novopen Download PDFInfo
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- CN103656782B CN103656782B CN201210356841.7A CN201210356841A CN103656782B CN 103656782 B CN103656782 B CN 103656782B CN 201210356841 A CN201210356841 A CN 201210356841A CN 103656782 B CN103656782 B CN 103656782B
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- infusion
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- novopen
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- 238000001802 infusion Methods 0.000 title claims abstract description 149
- 238000000034 method Methods 0.000 title claims abstract description 34
- 238000012544 monitoring process Methods 0.000 title abstract description 15
- 238000001514 detection method Methods 0.000 claims abstract description 38
- 230000008569 process Effects 0.000 claims abstract description 17
- 238000012360 testing method Methods 0.000 claims description 15
- 230000002085 persistent effect Effects 0.000 claims description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract description 44
- 102000004877 Insulin Human genes 0.000 abstract description 22
- 108090001061 Insulin Proteins 0.000 abstract description 22
- 229940125396 insulin Drugs 0.000 abstract description 22
- 229940127560 insulin pen Drugs 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention provides a kind of method and apparatus monitoring the infusion of novopen, incorporate: first detects, for detecting whether completed infusion requirement unit; Whether the second detection, not yet complete for timing detection infusion or whether motor continues infusion after normal time needed for infusion; And the 3rd detects, and for detection instant in infusion process, whether motor and control data fault occurs.As long as any one integrated detects effectively, just can detect the condition needing to close or interrupt infusion in time, thus close in time or interrupt infusion, infusion risk can be taken precautions against better.Further, the exercise price of this method for supervising is cheap and realize simple, can flexible Application in various infusion of insulin pens on the market.
Description
Technical field
The present invention relates to the method and apparatus of the infusion for monitoring novopen.
Background technology
The sickness rate of diabetes increases day by day, has become the third-largest killer after cardiovascular and cerebrovascular disease and tumor.Think at present, infusion of insulin treatment is the effective ways for the treatment of diabetes.Carry out intensive treatment by infusion of insulin, the overall up to standard such as patient blood glucose, blood fat, blood pressure and BMI can be made, and the high accuracy infusion of electrical type insulin infusion devices is the best means of insulin intensive treatment.
In infusion of insulin therapeutic process, the accuracy of infusion dosage is most important, and underdosage can cause hyperglycemia and then easily lead to complications, even and dosage that patient's hypoglycemia too much can be caused to cause patient to go into a coma is even dead.Therefore, safety and precise ground infusion of insulin is most important.Usual insulin requirement carries out infusion for a long time, and therefore most patient adopts various types of insulin infusion device to carry out infusion of insulin.
In various types of insulin infusion device, novopen is that price is very cheap, structure simple a kind of insulin infusion device relative to structure, size is more bigger than pen, insulin is placed in pen in the mode of pen core, can carry with, used time only need pull up the cap for brush, and just can carry out infusion of insulin, operation is very easy.The insulin that it uses is special writing-core type insulin, and concentration is different from general insulin, is U-100, i.e. 100 units per ml (general insulin concentration is U-40,40 units per ml, Mei Zhi 400 unit).Writing-core type insulin be generally 300 units/or 150 units/, after being finished, replaceable pen core continues to use again.
By Lilly Co., Eli., " promise and " pen that at present leading in Chinese market infusion of insulin pen produces that " excellent companion " pen and Novo Nordisk Co., Ltd of Denmark produce, state's insulin-producing also uses the infusion of insulin pen of import substantially.
For current infusion of insulin pen, in view of the price positioning that it is cheap, whole design idea is all mechanically driver type structure, and such as motor drives, and, the monitoring that in monitoring to it, many employings are simply single, analogy only detects infusion and requires whether unit completes and then stop infusion accordingly, or only monitor " afterwards type " detection whether motor continues to turn after completing infusion requirement unit, will cause after this single monitoring was lost efficacy novopen wrong infusion thus to the health of diabetics even life threaten, and " instant type " monitoring cannot be carried out in infusion process simultaneously, that is, infusion is interrupted in time when cannot make a mistake in the control data such as controlling infusion process.
Therefore, need to provide a kind of method and apparatus monitoring the infusion of novopen, the method and device can integrate whether detection has completed infusion requirement unit, whether timing detect infusion and to complete or whether motor also continues to turn after infusion completes and whether instant detection motor and control data fault occur in infusion process on time.As long as any one integrated detects effectively, just can detect the condition needing to close or interrupt infusion in time, thus close in time or interrupt infusion, thus infusion risk can be taken precautions against better.Further, the exercise price of this method for supervising is cheap and realize simple.
Summary of the invention
The invention provides a kind of method monitoring the infusion of novopen, the method integrates following three kinds of detections: first detects, for detecting whether completed infusion requirement unit; Whether the second detection, not yet complete for timing detection infusion or whether motor continues infusion after normal time needed for infusion; And the 3rd detects, and for detection instant in infusion process, whether motor and control data fault occurs.
Preferably, if above-mentioned three kinds of testing results detecting any one are yes, then described method makes novopen close infusion.
Preferably, described first detection utilizes following step to realize: calculate the infusion number of times that single infusion amount is minimum infusion unit, once infusion number of times reaches infusion requirement number of times, then close infusion immediately, wherein, infusion requires with infusion, number of times is by requiring that unit obtains divided by minimum infusion unit.
Preferably, described first detect by software encoder being accessed monolithic counter and carrying out corresponding programming to realize.
Preferably, certain multiplying power of described timing normal time needed for infusion.Preferably, described certain multiplying power is selected from the scope of 1.2 ~ 1.5 times.
Preferably, if described second detects and not yet complete infusion, then preliminary judgement electrical fault or the control data that controls infusion process are lost; Complete infusion but motor continues to turn if detected, then judge that motor often turns and do not stop, both of these case closes power supply to feeding electric motors and same alarm all immediately.
Preferably, described 3rd detection utilizes square wave testing circuit to realize, the input of described square wave testing circuit connects the input/output end port of single-chip microcomputer and connects the outfan of hardware coder, outfan is then connected to power supply as power control terminal, described hardware coder is coupled to motor and generates and sine wave output when electric machine rotation, and described power supply is used for powering to motor and hardware coder.
Preferably, when infusion starts, described single-chip microcomputer inputs the high level of a short persistent period to this square wave testing circuit, powers to motor and hardware coder to start power supply.
Present invention also offers a kind of device monitoring the infusion of novopen, comprising: for detecting the module whether completing infusion requirement unit; Detect infusion for timing whether not yet to complete or whether motor continues the module of infusion after normal time needed for infusion; And the module of motor and control data fault whether is there is for detection instant in infusion process.
Accompanying drawing explanation
In order to more clearly describe technical scheme of the present invention, briefly introduce below in conjunction with accompanying drawing.Obviously, these accompanying drawings are only some detailed description of the invention that the application records.These accompanying drawings following are included but not limited to according to of the present invention.
Fig. 1 illustrates for carrying out the 3rd square wave testing circuit detected.
Fig. 2 illustrates the device of the infusion of the monitoring novopen according to the embodiment of the present invention.
Detailed description of the invention
In order to understand the present invention further, below in conjunction with embodiment, preferred version of the present invention is described.These descriptions just illustrate the features and advantages of the present invention, but not limit the scope of the invention.
The invention provides a kind of method monitoring the infusion of novopen, the method integrates following three kinds of detections: detect whether completed infusion requirement unit; Whether timing detection infusion completes on time or whether motor continues infusion after normal time needed for infusion; And whether instant detection there is motor and control data fault in infusion process.
Below above-mentioned three kinds of contents detected and implementation thereof are described in detail.
One. first detects
Described first detects whether completed infusion requirement unit, if completed infusion requirement unit, then closes infusion immediately.Particularly, first detection can utilize following step to realize: calculate the infusion number of times that single infusion amount is minimum infusion unit, once infusion number of times reaches infusion requirement number of times, then close infusion immediately, wherein, infusion requires with infusion, number of times is by requiring that unit obtains divided by minimum infusion unit.
Described first detects and by software encoder is accessed monolithic counter, and can work out following program to realize:
Two, second detect
The time of described second detection certain multiplying power of normal time needed for infusion, detect whether complete infusion.This multiplying power can be selected in the scope of 1.2 ~ 1.5 times.If detect and not yet complete infusion, then the control data of preliminary judgement electrical fault or control infusion process is lost; If detect and complete infusion but motor continuation turn, then judge that motor often turns and do not stop, above two kinds of situation generation any one, close the power supply to feeding electric motors and same alarm all immediately.
Exemplarily, described second detect can by working out following program to realize to intervalometer sum counter:
Three, the 3rd detect
Above first detects to be merely able to accurately monitor when infusion process normally performs when close infusion, and second detects just can only can judge whether break down after the timing exceeding normal Infusion Time, both all cannot find in infusion process that motor does not turn or control data loses mistake and so on problem in time.
3rd detects for supplementing above-mentioned two kinds of detections, and have employed the mode of hardware coder driving.Illustrate for carrying out the 3rd square wave testing circuit detected in Fig. 1, the input of described square wave testing circuit connects the input/output end port of single-chip microcomputer and connects the outfan of hardware coder, outfan is then connected to power supply as power control terminal, described hardware coder is coupled to motor and generates and sine wave output when electric machine rotation, and described power supply is used for powering to motor and hardware coder.
In normal infusion process, when infusion starts, single-chip microcomputer is by inputting the high level of a short persistent period to this square wave testing circuit, the high level making this square wave testing circuit export the shorter persistent period is powered to motor and hardware coder for starting power supply (such as power supply chip), electric machine rotation thus, and then make hardware coder sine wave output, this sine wave is imported into described square wave testing circuit, make its outfan maintain high level, thus maintenance driving power is powered to motor and hardware coder.
When infusion complete, motor stalling or hardware coder fault time, cannot sine wave output, then low level fallen by the outfan of this square wave testing circuit, thus power cutoff stops the power supply to motor, stops infusion.Thereby, it is possible to find fault in time and stop infusion in infusion process, thus effectively protect the safety of equipment.
Utilize this method for supervising, infusion can be closed immediately after completing infusion requirement unit, even if still can detect that infusion mistake or motor continue turn and then interrupt infusion in time after infusion in timing place of the certain multiplying power of normal time needed for infusion when this detection was lost efficacy, even when this timing detects and also lost efficacy, the instant detection of infusion process can also be utilized to find any motor and control data fault, and then better take precautions against infusion risk.The method of the infusion for monitoring novopen of the present invention incorporates as above three kinds of detections, as long as any one integrated detects effectively, just can detect the condition needing to close or interrupt infusion in time, thus close in time or interrupt infusion, infusion risk can be taken precautions against better.Further, the exercise price of this method for supervising is cheap and realize simple, can flexible Application in various infusion of insulin pens on the market.
According to another embodiment of the present invention, additionally provide a kind of device 1 monitoring the infusion of novopen, this device 1 comprises: for detecting the module 2 whether completing infusion requirement unit; Detect infusion for timing whether not yet to complete or whether motor continues the module 3 of infusion after normal time needed for infusion; And the module 4 of motor and control data fault whether is there is for detection instant in infusion process.
In view of this device includes as above three kinds of detection modules, as long as included any one module is effective, just can detects the condition needing to close or interrupt infusion in time, thus close in time or interrupt infusion, infusion risk can be taken precautions against better.And, as above about method for supervising example described in, software encoder, hardware coder and single-chip microcomputer etc. can be utilized easily to buy for three kinds of detection modules of this device and cheap element realizes, easy realization with low cost, can flexible Application in various infusion of insulin pens on the market.
The explanation of above embodiment just understands core concept of the present invention for helping.It should be pointed out that for the ordinary skill in the art, under the premise without departing from the principles of the invention, some improvement and modification can also be carried out to the present invention, but these improve and modification also falls in the scope of the claims in the present invention request protection.
Claims (9)
1. monitor a device for novopen infusion, this device comprises: for detecting the first detection module whether completing infusion requirement unit; Detect infusion for timing whether to complete or after normal time needed for infusion, whether motor continues the second detection module of infusion; And the 3rd detection module of motor and control data fault whether is there is for detection real-time in infusion process.
2. device according to claim 1, wherein, if the arbitrary detection module testing result in described first detection module, the second detection module and the 3rd detection module is yes, then described device makes novopen close infusion.
3. device according to claim 1, wherein, described first detection module utilizes following step to realize: calculate the infusion number of times that single infusion amount is minimum infusion unit, once infusion number of times reaches infusion requirement number of times, then close infusion immediately, wherein, infusion requires with infusion, number of times is by requiring that unit obtains divided by minimum infusion unit.
4. device according to claim 1, wherein, described first detection module is by accessing monolithic counter by software encoder and carrying out corresponding programming to realize.
5. device according to claim 1, wherein, certain multiplying power of duration normal time needed for infusion of timing in described second detection module.
6. device according to claim 5, wherein, described certain multiplying power is 1.2 ~ 1.5 times.
7. device according to claim 1, wherein, if described second detection module detects not yet complete infusion, then the control data of preliminary judgement electrical fault or control infusion process is lost; Complete infusion but motor continues to turn if detected, then judge that motor often turns and do not stop, both of these case closes power supply to feeding electric motors and same alarm all immediately.
8. device according to claim 1, wherein, described 3rd detection module utilizes square wave testing circuit to realize, the input of described square wave testing circuit connects the input/output end port of single-chip microcomputer and connects the outfan of hardware coder, outfan is then connected to power supply as power control terminal, described hardware coder is coupled to motor and generates and sine wave output when electric machine rotation, and described power supply is used for powering to motor and hardware coder.
9. device according to claim 8, wherein, when infusion starts, described single-chip microcomputer inputs the high level of a short persistent period to this square wave testing circuit, powers to motor and hardware coder to start power supply.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210356841.7A CN103656782B (en) | 2012-09-21 | 2012-09-21 | For monitoring the method and apparatus of the infusion of novopen |
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| CN201210356841.7A CN103656782B (en) | 2012-09-21 | 2012-09-21 | For monitoring the method and apparatus of the infusion of novopen |
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| CN103656782A CN103656782A (en) | 2014-03-26 |
| CN103656782B true CN103656782B (en) | 2016-04-13 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105597185A (en) * | 2016-01-26 | 2016-05-25 | 北京英诺达医疗科技有限公司 | Excessive injection preventing device and method for injection pump |
| CN106375333B (en) * | 2016-09-27 | 2019-10-22 | 上海移宇科技股份有限公司 | It is a kind of to be transfused safe method of assuring and the body-worn medical device using this method |
| CN113786533A (en) * | 2021-09-30 | 2021-12-14 | 北京伏尔特技术有限公司 | Insulin infusion control method and system for insulin pump and insulin pump |
| CN118159190A (en) * | 2021-10-25 | 2024-06-07 | 上海移宇科技有限公司 | Closed-loop artificial pancreas insulin infusion control system |
| US20240424207A1 (en) * | 2021-10-25 | 2024-12-26 | Medtrum Technologies Inc. | Closed-loop artificial pancreas insulin infusion control system |
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| CN88102557A (en) * | 1987-05-08 | 1988-12-14 | 斯普卢特-海伦公司 | Injection pen |
| EP1240913A2 (en) * | 2001-03-15 | 2002-09-18 | Nipro Corporation | Pen-type injector for liquid medicine |
| CN101862489A (en) * | 2010-06-13 | 2010-10-20 | 江苏华阳电器有限公司 | A medicine injector and its control method |
| CN201692439U (en) * | 2010-06-13 | 2011-01-05 | 江苏华阳电器有限公司 | a medicine syringe |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL156245A0 (en) * | 2000-12-22 | 2004-01-04 | Dca Design Int Ltd | Drive mechanism for an injection device |
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2012
- 2012-09-21 CN CN201210356841.7A patent/CN103656782B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN88102557A (en) * | 1987-05-08 | 1988-12-14 | 斯普卢特-海伦公司 | Injection pen |
| EP1240913A2 (en) * | 2001-03-15 | 2002-09-18 | Nipro Corporation | Pen-type injector for liquid medicine |
| CN101862489A (en) * | 2010-06-13 | 2010-10-20 | 江苏华阳电器有限公司 | A medicine injector and its control method |
| CN201692439U (en) * | 2010-06-13 | 2011-01-05 | 江苏华阳电器有限公司 | a medicine syringe |
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