CN103656738A - Novel vitreous body filler and preparation method thereof - Google Patents
Novel vitreous body filler and preparation method thereof Download PDFInfo
- Publication number
- CN103656738A CN103656738A CN201310678097.7A CN201310678097A CN103656738A CN 103656738 A CN103656738 A CN 103656738A CN 201310678097 A CN201310678097 A CN 201310678097A CN 103656738 A CN103656738 A CN 103656738A
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- CN
- China
- Prior art keywords
- vitreous body
- body filler
- preparation
- novel
- novel vitreous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 210000004127 vitreous body Anatomy 0.000 title abstract description 15
- 239000000945 filler Substances 0.000 title abstract description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229940057995 liquid paraffin Drugs 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract 2
- 239000007943 implant Substances 0.000 claims description 14
- 239000011521 glass Substances 0.000 claims description 6
- 210000001525 retina Anatomy 0.000 abstract description 6
- 230000003287 optical effect Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 235000011187 glycerol Nutrition 0.000 abstract 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000009969 flowable effect Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 229920002545 silicone oil Polymers 0.000 description 5
- 206010038848 Retinal detachment Diseases 0.000 description 4
- 230000004264 retinal detachment Effects 0.000 description 4
- 238000002513 implantation Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010058046 Post procedural complication Diseases 0.000 description 1
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 208000002367 Retinal Perforations Diseases 0.000 description 1
- 206010038897 Retinal tear Diseases 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000007159 enucleation Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Images
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- Materials For Medical Uses (AREA)
Abstract
The invention discloses novel vitreous body filler and a preparation method thereof. The novel vitreous body filler is flowable viscous liquid and comprises liquid paraffin and glycerin. The preparation method comprises the following steps: mixing 10-20ml of liquid paraffin and 20-30ml of glycerin, and carrying out autoclaved sterilization, thus obtaining the novel vitreous body filler. The novel vitreous body filler has the beneficial effects that the novel vitreous body filler has a retina restoration effect, stable inertia, optical transparency and small biological compatibility and can be directly injected in the operation.
Description
technical field:
The present invention relates to a kind of preparation field of vitreous body implant, relate in particular to a kind of ophthalmology vitreous body implant preparation field.
technical background:
Vitreous body implant implantation is used for the treatment of the reattachment of retina after the vitreous body enucleation of complicated retinal detachment.Vitreous chamber implant is the indispensable material for the treatment of complicated retinal detachment, and choosing packing material is the key of successful surgery, also the impact great on having of prognosis, complication.
From reported first in 1911, at vitreous chamber, inject air repairing retina and depart from so far, people find desirable vitreous substitute always constantly.Think that at present desirable vitreous substitute should have following characteristic: 1. water white transparency, avirulence, no antigen; 2. surface tension is large, can push up and press irregular surface; 3. proportion is low, can push up the side's of pressing retinal hole, or proportion is greater than water, ceasma that can the side of depressing, gravity top; 4. there is not emulsifying or dispersion; 5. viscosity is suitable, is convenient to inject or sucking-off.
Since within 1962, using silicone oil treatment detachment of retina, silicone oil approaches vitreous body with refractive index, has the advantages such as good optical transparence, toxicity are low, long action time, becomes the vitreous chamber implant of at present conventional complicated retinal detachment.Though many complicated retinal detachment persons' vision has been saved in the application of silicone oil, the postoperative complication of silicone oil has also affected the recovery of Postoperative visual acuity to a certain extent, has limited the application of silicone oil.Other also have gas filler etc., but also due to operation inconvenience, and fail extensively to promote.
summary of the invention:
Goal of the invention: design a kind of novel glass body implant, have reattachment of retina biocompatibility little, physicochemical property is stable, the feature of fluent material.
Technical scheme:
The invention provides a kind of novel glass body implant and preparation method thereof.Technical scheme is that liquid paraffin 10-20ml and glycerol 20-30ml are mixed, and autoclaving, obtains.
Accompanying drawing explanation
Accompanying drawing 1 vitreous body implant injection model figure.1. vitreous body implant ascending pipe; 2. gently manage; 3. vitreous body.
useful benefit:
Vitreous body implant prepared by the present invention, has reattachment of retina effect, stable inertia, optical transparence, and biocompatibility is little, the feature that operation can directly be injected.
the specific embodiment:
embodiment 1:liquid paraffin 10ml and glycerol 30ml are mixed, and autoclaving, obtains.
embodiment 2:liquid paraffin 20ml and glycerol 20ml are mixed, and autoclaving, obtains.
Claims (3)
1. a novel glass body implant, is characterized in that: be the thick liquid of the shape that flows.
2. a novel glass body implant, is characterized in that: liquid paraffin and glycerol, consist of.
3. novel glass body implant preparation method: it is characterized in that: liquid paraffin 10-20ml and glycerol 20-30ml are mixed, and autoclaving, obtains.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310678097.7A CN103656738A (en) | 2013-12-13 | 2013-12-13 | Novel vitreous body filler and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310678097.7A CN103656738A (en) | 2013-12-13 | 2013-12-13 | Novel vitreous body filler and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103656738A true CN103656738A (en) | 2014-03-26 |
Family
ID=50296291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310678097.7A Pending CN103656738A (en) | 2013-12-13 | 2013-12-13 | Novel vitreous body filler and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103656738A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001070132A2 (en) * | 2000-03-20 | 2001-09-27 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
| CN201734718U (en) * | 2010-08-10 | 2011-02-09 | 王宁利 | Body position monitor after silicone oil injection surgery |
| CN103202742A (en) * | 2012-01-14 | 2013-07-17 | 上海市第一人民医院 | Hand held type silicone oil pumping kit |
-
2013
- 2013-12-13 CN CN201310678097.7A patent/CN103656738A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001070132A2 (en) * | 2000-03-20 | 2001-09-27 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
| CN201734718U (en) * | 2010-08-10 | 2011-02-09 | 王宁利 | Body position monitor after silicone oil injection surgery |
| CN103202742A (en) * | 2012-01-14 | 2013-07-17 | 上海市第一人民医院 | Hand held type silicone oil pumping kit |
Non-Patent Citations (1)
| Title |
|---|
| 段聪 等: "硅油在玻璃体视网膜手术中的应用进展", 《医学综述》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140326 |