CN103656297B - A kind of Chinese drugs agentia for the treatment of otitis media and preparation method thereof - Google Patents
A kind of Chinese drugs agentia for the treatment of otitis media and preparation method thereof Download PDFInfo
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- CN103656297B CN103656297B CN201310684316.2A CN201310684316A CN103656297B CN 103656297 B CN103656297 B CN 103656297B CN 201310684316 A CN201310684316 A CN 201310684316A CN 103656297 B CN103656297 B CN 103656297B
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- 206010033078 Otitis media Diseases 0.000 title claims abstract description 30
- 239000003390 Chinese drug Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 35
- 229940079593 drug Drugs 0.000 claims abstract description 24
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 13
- 241000426256 Cyanotis Species 0.000 claims abstract description 13
- 241000628997 Flos Species 0.000 claims abstract description 13
- 241000594394 Hedyotis Species 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 10
- 238000002791 soaking Methods 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 5
- 210000003298 dental enamel Anatomy 0.000 claims description 2
- 230000000857 drug effect Effects 0.000 abstract description 4
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 229940126701 oral medication Drugs 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 4
- 210000000959 ear middle Anatomy 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 206010014020 Ear pain Diseases 0.000 description 2
- 206010014025 Ear swelling Diseases 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000007176 earache Diseases 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 210000002388 eustachian tube Anatomy 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000001595 mastoid Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 206010061819 Disease recurrence Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013196 antibiotherapy Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
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Abstract
The invention discloses a kind of Chinese drugs agentia for the treatment of otitis media and preparation method thereof, be made up of according to quality meter following crude drug: Radix abutili indici 5 ~ 8 parts, Radix Cyanotis vagae 9 ~ 13 parts, Herba Malvastri Coromandeliani 5 ~ 8 parts, Auricled Hedyotis Herb 3 ~ 8 parts, Flos Lonicerae 10 ~ 20 parts, Radix Rehmanniae Preparata 6 ~ 9 parts, Fructus Momordicae 12 ~ 20 parts, Borneolum Syntheticum 6 ~ 12 parts, Sanguis Monopteri albi 5 ~ 8 parts, Periostracum Cicadae 10 ~ 14 parts, Ungula Francolini 5 ~ 8 parts; Compared with prior art have the following advantages: one side drug effect is remarkable, enhancing patient resistance; Cheap, have no side effect, and preparation method being easy, being suitable for clinical practice, is oral drugs on the other hand, uses more convenient, not easily recur than external used medicine.
Description
Technical field
The present invention relates to Chinese medicine preparation and preparation method thereof, particularly relate to a kind of Chinese drugs agentia for the treatment of otitis media and preparation method thereof.
Background technology
Otitis media is a kind of disease of harm humans health, and otitis media is the inflammatory lesion of involving middle ear (comprising pharyngotympanic tube, tympanum, tympanic antrum and mastoid air cell) all or part of structure; This inflammation, as treated not in time, also easily causes other concurrent inflammation, causes larger injury to patient.Current general treatement is antibiotic therapy or more serious has surgical operation therapy, but the antibiotherapy of Western medicine easily develops immunity to drugs, not easily life-time service, and to the adverse effect that patient body causes immunity to reduce; In addition more existing Chinese medicine preparation effects are not fine yet.
Summary of the invention
Goal of the invention: in order to solve the problem existing for prior art, the invention provides a kind of drug effect significantly, the Chinese drugs agentia taking treatment otitis media that is convenient, that not easily recur and preparation method thereof.
Technical scheme: for achieving the above object, the present invention is by the following technical solutions: a kind of Chinese drugs agentia for the treatment of otitis media, is made up of according to quality meter following crude drug: Radix abutili indici 5 ~ 8 parts, Radix Cyanotis vagae 9 ~ 13 parts, Herba Malvastri Coromandeliani 5 ~ 8 parts, Auricled Hedyotis Herb 3 ~ 8 parts, Flos Lonicerae 10 ~ 20 parts, Radix Rehmanniae Preparata 6 ~ 9 parts, Fructus Momordicae 12 ~ 20 parts, Borneolum Syntheticum 6 ~ 12 parts, Sanguis Monopteri albi 5 ~ 8 parts, Periostracum Cicadae 10 ~ 14 parts, Ungula Francolini 5 ~ 8 parts.
As a further improvement on the present invention, described each crude drug consumption is composed as follows according to quality meter: Radix abutili indici 7 parts, Radix Cyanotis vagae 11 parts, Herba Malvastri Coromandeliani 7 parts, Auricled Hedyotis Herb 6 parts, Flos Lonicerae 15 parts, Radix Rehmanniae Preparata 7 parts, Fructus Momordicae 16 parts, Borneolum Syntheticum 8 parts, Sanguis Monopteri albi 7 parts, Periostracum Cicadae 12 parts, Ungula Francolini 6 parts.
The preparation method of the Chinese drugs agentia of above-mentioned treatment otitis media, comprises the following steps:
(1) all crude drug are ready to according to institute's expense;
(2) first Radix abutili indici, Radix Cyanotis vagae, Herba Malvastri Coromandeliani, Auricled Hedyotis Herb four kinds of crude drug mixing and water addings are soaked, water consumption is 8 ~ 10 times of four kinds of crude drug weight summations, after soaking 15min, rear slow fire continuation decoction 20 ~ 25min is boiled in big fire, add Flos Lonicerae, Radix Rehmanniae Preparata, Fructus Momordicae and Borneolum Syntheticum again, big fire leaches medicinal liquid after boiling rear continuation decoction 10 ~ 15min, obtains filtering residue;
(3) Periostracum Cicadae and Ungula Francolini are ground into powder, after mixing with the filtering residue in step (2) together with Sanguis Monopteri albi, the water adding gross weight 2 ~ 4 times soaks, and after soaking 10min, big fire is boiled, and leaches medicinal liquid after continuing slow fire boiling 15 ~ 20min;
(4) Chinese drugs agentia of described treatment otitis media is namely obtained after the medicinal liquid mixing obtained in step (2), (3).
For better ensureing decocting for Chinese herbal medicine effect, described decoction container is marmite or enamel ware.、
Beneficial effect: a kind of Chinese drugs agentia for the treatment of otitis media provided by the present invention and preparation method thereof, compared with prior art has the following advantages: one side drug effect is remarkable, enhancing patient resistance; Cheap, have no side effect, and preparation method being easy, being suitable for clinical practice, is oral drugs on the other hand, uses more convenient, not easily recur than external used medicine.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described:
Embodiment 1:
Treat a Chinese drugs agentia for otitis media, be made up of according to quality meter following crude drug: Radix abutili indici 5 parts, Radix Cyanotis vagae 9 parts, Herba Malvastri Coromandeliani 5 parts, Auricled Hedyotis Herb 3 parts, Flos Lonicerae 10 parts, Radix Rehmanniae Preparata 6 parts, Fructus Momordicae 12 parts, Borneolum Syntheticum 6 parts, Sanguis Monopteri albi 5 parts, Periostracum Cicadae 10 parts, Ungula Francolini 5 parts.
The preparation method of the Chinese drugs agentia of above-mentioned treatment otitis media, comprises the following steps:
(1) all crude drug are ready to according to institute's expense;
(2) marmite is adopted to carry out the decoction of medicament, first Radix abutili indici, Radix Cyanotis vagae, Herba Malvastri Coromandeliani, Auricled Hedyotis Herb four kinds of crude drug mixing and water addings are soaked, water consumption is 8 times of four kinds of crude drug weight summations, after soaking 15min, rear slow fire continuation decoction 20min is boiled in big fire, add Flos Lonicerae, Radix Rehmanniae Preparata, Fructus Momordicae and Borneolum Syntheticum again, big fire is boiled after rear continuation decocts 10min and is leached medicinal liquid, obtains filtering residue;
(3) Periostracum Cicadae and Ungula Francolini are ground into powder, after mixing with the filtering residue in step (2) together with Sanguis Monopteri albi, the water adding gross weight 2 times soaks, and after soaking 10min, big fire is boiled, and leaches medicinal liquid after continuing slow fire boiling 15min;
(4) Chinese drugs agentia of described treatment otitis media is namely obtained after the medicinal liquid mixing obtained in step (2), (3).
Embodiment 2:
Treat a Chinese drugs agentia for otitis media, be made up of according to quality meter following crude drug: Radix abutili indici 7 parts, Radix Cyanotis vagae 11 parts, Herba Malvastri Coromandeliani 7 parts, Auricled Hedyotis Herb 6 parts, Flos Lonicerae 15 parts, Radix Rehmanniae Preparata 7 parts, Fructus Momordicae 16 parts, Borneolum Syntheticum 8 parts, Sanguis Monopteri albi 7 parts, Periostracum Cicadae 12 parts, Ungula Francolini 6 parts.
The preparation method of the Chinese drugs agentia of above-mentioned treatment otitis media, comprises the following steps:
(1) all crude drug are ready to according to institute's expense;
(2) marmite is adopted to carry out the decoction of medicament, first Radix abutili indici, Radix Cyanotis vagae, Herba Malvastri Coromandeliani, Auricled Hedyotis Herb four kinds of crude drug mixing and water addings are soaked, water consumption is 9 times of four kinds of crude drug weight summations, after soaking 15min, rear slow fire continuation decoction 22min is boiled in big fire, add Flos Lonicerae, Radix Rehmanniae Preparata, Fructus Momordicae and Borneolum Syntheticum again, big fire is boiled after rear continuation decocts 12min and is leached medicinal liquid, obtains filtering residue;
(3) Periostracum Cicadae and Ungula Francolini are ground into powder, after mixing with the filtering residue in step (2) together with Sanguis Monopteri albi, the water adding gross weight 3 times soaks, and after soaking 10min, big fire is boiled, and leaches medicinal liquid after continuing slow fire boiling 18min;
(4) Chinese drugs agentia of described treatment otitis media is namely obtained after the medicinal liquid mixing obtained in step (2), (3).
Embodiment 3:
Treat a Chinese drugs agentia for otitis media, be made up of according to quality meter following crude drug: Radix abutili indici 8 parts, Radix Cyanotis vagae 13 parts, Herba Malvastri Coromandeliani 8 parts, Auricled Hedyotis Herb 8 parts, Flos Lonicerae 20 parts, Radix Rehmanniae Preparata 9 parts, Fructus Momordicae 20 parts, Borneolum Syntheticum 12 parts, Sanguis Monopteri albi 8 parts, Periostracum Cicadae 14 parts, Ungula Francolini 8 parts.
The preparation method of the Chinese drugs agentia of above-mentioned treatment otitis media, comprises the following steps:
(1) all crude drug are ready to according to institute's expense;
(2) marmite is adopted to carry out the decoction of medicament, first Radix abutili indici, Radix Cyanotis vagae, Herba Malvastri Coromandeliani, Auricled Hedyotis Herb four kinds of crude drug mixing and water addings are soaked, water consumption is 10 times of four kinds of crude drug weight summations, after soaking 15min, rear slow fire continuation decoction 25min is boiled in big fire, add Flos Lonicerae, Radix Rehmanniae Preparata, Fructus Momordicae and Borneolum Syntheticum again, big fire is boiled after rear continuation decocts 15min and is leached medicinal liquid, obtains filtering residue;
(3) Periostracum Cicadae and Ungula Francolini are ground into powder, after mixing with the filtering residue in step (2) together with Sanguis Monopteri albi, the water adding gross weight 4 times soaks, and after soaking 10min, big fire is boiled, and leaches medicinal liquid after continuing slow fire boiling 20min;
(4) Chinese drugs agentia of described treatment otitis media is namely obtained after the medicinal liquid mixing obtained in step (2), (3).
The present invention cures mainly the symptoms such as pharyngotympanic tube, tympanum, tympanic antrum and the mastoid air cell caused by otitis media.The beneficial effect of medicine of the present invention is set forth further below by way of clinical case:
(1) clinical data and Therapeutic Method
With test group treatment otitis media patient 50 example, compare with matched group 50 example.
test group:chinese drugs agentia in the present invention described in embodiment 1-3, is decocted in water for oral dose, every day potion, sooner or later sub-service.Taking medicine continuously 7 days is 1 course for the treatment of;
matched group:adopt conventional medicine to treat, every day three times 7 days was 1 course for the treatment of.
Test group and matched group patient were fully recovered in 3 months and pays a return visit, investigate and record otitis media disease recurrence.
(2) curative effect determinate standard
A) effective: the transference cure such as erosion of the auricle, otalgia, tinnitus in treatment 5d; Ear's swelling hyperemia alleviates, and ear's purulent secretion disappears; Auditory rehabilitation is normal, other concurrent uncomfortable transference cures.
B) effective: in treatment 5 ~ 7d, the symptom such as erosion of the auricle, otalgia, tinnitus is clearly better; Ear's swelling hyperemia alleviates, and ear's purulent secretion disappears and obviously alleviates or disappear; Auditory rehabilitation is normal, and other concurrent uncomfortable symptoms obviously alleviate or disappear.
C) invalid: treatment 7d patients symptomatic and sign, without obviously alleviating, even increase the weight of.
(3) clinical effectiveness
Test group and matched group comparitive study, in table 1.
Table 1 test group and matched group comparitive study
| Effective | Effectively | Invalid | Add up to | Effective percentage (%) | Relapse rate (%) | |
| Test group | 32 | 15 | 3 | 50 | 94 | 0 |
| Matched group | 9 | 15 | 26 | 50 | 48 | 25 |
Clinical effectiveness shows: test group treatment otitis media patient 50 example, and total effective rate reaches 94%, 0 recurrence in three months, with the total effective rate of matched group 50 example 46% and in three months 25% relapse rate compare, be obviously better than matched group.Illustrate that Drug therapy otitis media of the present invention is evident in efficacy, drug effect significantly and not easily recur, has good promotional value.
Should be understood that, above detailed description of the invention is only not used in for illustration of the present invention and limits the scope of the invention, after having read the present invention, the amendment of those skilled in the art to the various equivalent form of value of the present invention has all fallen within the application's claims limited range.
Claims (4)
1. treat the Chinese drugs agentia of otitis media for one kind, it is characterized in that, be prepared from by the crude drug of following parts by weight: Radix abutili indici 5 ~ 8 parts, Radix Cyanotis vagae 9 ~ 13 parts, Herba Malvastri Coromandeliani 5 ~ 8 parts, Auricled Hedyotis Herb 3 ~ 8 parts, Flos Lonicerae 10 ~ 20 parts, Radix Rehmanniae Preparata 6 ~ 9 parts, Fructus Momordicae 12 ~ 20 parts, Borneolum Syntheticum 6 ~ 12 parts, Sanguis Monopteri albi 5 ~ 8 parts, Periostracum Cicadae 10 ~ 14 parts, Ungula Francolini 5 ~ 8 parts.
2. the Chinese drugs agentia for the treatment of otitis media according to claim 1, it is characterized in that, be prepared from by the crude drug of following parts by weight: Radix abutili indici 7 parts, Radix Cyanotis vagae 11 parts, Herba Malvastri Coromandeliani 7 parts, Auricled Hedyotis Herb 6 parts, Flos Lonicerae 15 parts, Radix Rehmanniae Preparata 7 parts, Fructus Momordicae 16 parts, Borneolum Syntheticum 8 parts, Sanguis Monopteri albi 7 parts, Periostracum Cicadae 12 parts, Ungula Francolini 6 parts.
3. a preparation method for the Chinese drugs agentia for the treatment of otitis media as claimed in claim 1, is characterized in that comprising the following steps:
(1) all crude drug are ready to according to institute's expense;
(2) first Radix abutili indici, Radix Cyanotis vagae, Herba Malvastri Coromandeliani, Auricled Hedyotis Herb four kinds of crude drug mixing and water addings are soaked, water consumption is 8 ~ 10 times of four kinds of crude drug weight summations, after soaking 15min, rear slow fire continuation decoction 20 ~ 25min is boiled in big fire, add Flos Lonicerae, Radix Rehmanniae Preparata, Fructus Momordicae and Borneolum Syntheticum again, big fire leaches medicinal liquid after boiling rear continuation decoction 10 ~ 15min, obtains filtering residue;
(3) Periostracum Cicadae and Ungula Francolini are ground into powder, after mixing with the filtering residue in step (2) together with Sanguis Monopteri albi, the water adding gross weight 2 ~ 4 times soaks, and after soaking 10min, big fire is boiled, and leaches medicinal liquid after continuing slow fire boiling 15 ~ 20min;
(4) Chinese drugs agentia of described treatment otitis media is namely obtained after the medicinal liquid mixing obtained in step (2), (3).
4. the preparation method of the Chinese drugs agentia for the treatment of otitis media according to claim 3, is characterized in that: described decoction container is marmite or enamel ware.
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| CN201310684316.2A CN103656297B (en) | 2013-12-16 | 2013-12-16 | A kind of Chinese drugs agentia for the treatment of otitis media and preparation method thereof |
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| CN103656297B true CN103656297B (en) | 2016-01-27 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822693A (en) * | 2010-04-29 | 2010-09-08 | 周莹 | Medicine treating tympanitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822693A (en) * | 2010-04-29 | 2010-09-08 | 周莹 | Medicine treating tympanitis |
Non-Patent Citations (2)
| Title |
|---|
| 治中耳炎的小验方;顾雪冬;《中国医药报》;20030407;第1页 * |
| 食用珍禽——美国鹧鸪;高拾如;《山西老年》;19991231(第8期);第43页 * |
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