CN103610928B - 一种治疗过敏性紫癜性肾炎的中药 - Google Patents
一种治疗过敏性紫癜性肾炎的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗过敏性紫癜性肾炎的中药，由以下重量配比的药材制备而成：枫荷梨10份、大叶狼豆柴14份、丁香罗勒14份、大叶南苏12份、透骨草10份、方叶五月茶12份、肥猪苗20份、飞来蓝14份、红石耳16份、蝶兰22份、东北蛔蒿8份、苔水花15份、芦子兰14份、复羽叶栾树10份、对生耳蕨14份、地涌金莲16份、臭黄荆根12份、费菜10份、法半夏16份、滇车前12份、多叶花椒16份、通城虎15份。临床实验证明，本发明能够安全有效治疗过敏性紫癜性肾炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗过敏性紫癜性肾炎的中药。
背景技术
过敏性紫癜性肾炎的基本病变是坏死性小血管炎免疫性疾病，特征为皮肤紫癜，出血性胃肠炎以及肾脏损害。其发病率通常患病年龄越大，肾损害发生率越高，肾脏病变程度也越重。过敏性紫癜肾炎是由于人体的毛细血管发生变态反应性炎症而导致肾脏发生病理损伤的慢性肾病。临床上，患者将出现皮肤紫癜、关节肿痛、腹痛、便血和血尿为特征的症状表现。症状轻重悬殊，除见皮肤，胃肠道，关节等症状外，早期大多数病人可见肉眼血尿与蛋白尿，轻者仅见镜下血尿。
对于过敏性紫癜性肾炎目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
枫荷梨【来源】为五加科植物权威参或变叶树参的根、茎或树皮。。秋、冬季采挖根部，确取茎枝或剥取树皮，洗净，切片，鲜用或晒用。【功能主治】祛风除湿；活血消肿。主风湿痹痛；偏瘫；头痛；月经不调；跌打损伤；疮肿。
大叶狼豆柴【来源】为豆科植物梯氏木蓝的根。夏、秋采收。【功能主治】软坚。治痞块。
丁香罗勒【来源】唇形科丁香罗勒OcimumgratissimumL.var.suave（Willd.）Hook.f.，以全草入药。【功能主治】发汗解表，祛风利湿，散瘀止痛。用于风寒感冒，头痛，胃腹胀满，消化不良，胃痛，肠炎腹泻，跌打肿痛，风湿关节痛；外用治蛇咬伤，湿疹，皮炎。
大叶南苏【来源】为天南星科植物大叶南苏的全株。全年均可采收，洗净，切段晒干或鲜用。【功能主治】散瘀止痛；舒筋活络；润肺止咳。主心绞痛；跌打肿痛；骨折；风湿疼痛；肢体麻木；支气管炎；百日咳。
透骨草【来源】大戟科地构叶属植物地构叶、凤仙花科草本植物凤仙花、紫葳科角蒿属植物角蒿、豆科野豌豆属植物山野豌豆的全草和杜鹃花科白珠树属植物滇白珠的全株。夏秋采。【功能主治】祛风除湿，解毒止痛。用于风湿关节痛；外用治疮疡肿毒。
方叶五月茶【来源】为大戟科植物方叶五月茶的叶春、夏季采摘，洗净，鲜用。【功能主治】拔脓止痒。主小儿头疮。
肥猪苗【来源】为菊科植物蒲儿根的全草。夏季采收，洗净，鲜用或晒干。【功能主治】清热解毒；利湿；活血。主痈疮肿毒；泌尿系感染；湿疹；跌打损伤。
飞来蓝【来源】为爵床科植物拟地皮消的全草。【功能主治】疏风清热；解毒利咽。主感冒发热；咽喉肿痛；折喉。
红石耳【来源】地衣类石耳科石耳属植物红腹石耳GyrophorahypocrocinaJatta，以叶状体入药。夏季雨后或细雨天采收，除去杂物，晒干。【功能主治】健胃消食，理气止痛。用于消化不良，小儿疳积，腹胀，腹痛，痢疾。
蝶兰【来源】为兰科植物蝶兰的全草。夏、秋季采收，鲜用或晒干。【功能主治】疏风解表；舒筋活络；接骨止痛。主感冒发热；头痛；风湿痹痛；跌打损伤；骨折。
东北蛔蒿【来源】菊科艾属植物东北蛔蒿ArtemisiafinitaKitag.，以花蕾入药。夏季花开放前采集，阴干。【功能主治】驱虫。用于蛔虫病。
苔水花【来源】荨麻科冷水花属植物苔水花Pileajaponica（Maxim.）Hand.-Mazz.，以全草入药。夏秋采，洗净晒干，或鲜用。【功能主治】清热解毒，渗湿利尿。用于扁桃体炎，尿路感染，子宫颈炎，赤白带下。
芦子兰【来源】胡椒科胡椒属植物荨麻叶胡椒PiperboehmeriaefoliumWall.，以全株入药。全年可采，切片晒干。【功能主治】祛风散寒，理气止痛。用于感冒，胃痛，痛经，跌打损伤，风湿骨痛。
复羽叶栾树【来源】为无患子科植物复羽叶栾树的根，根皮或花。夏、秋采收。【功能主治】疏风清热，止咳，杀虫。
对生耳蕨【来源】蕨类鳞毛蕨科对生耳蕨Polystichumdeltodon（Bak.）Diels，以全草入药。【功能主治】活血止痛，消肿，利尿，预防感冒；外用治跌打损伤，蛇咬伤。
地涌金莲【来源】为芭蕉科植物地涌金莲的花。夏、秋季花期采收，晒干或鲜用。【功能主治】止带；止血。主白带；崩漏；便血。
臭黄荆根【来源】为马鞭草科植物臭黄荆的根。秋后采收，洗净，切片晒干。【功能主治】清热；利湿。主痢疾；痔疮；脱肛；牙痛；水肿。
费菜【来源】为景天科植物费菜的全草或根。夏、秋采收，鲜用或晒干。【功能主治】活血，止血，宁心，利湿，消肿，解毒。治跌打损伤，咳血，吐血，便血，心悸，痈肿
法半夏【来源】本品为半夏的炮制加工品。【功能主治】燥湿化痰。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛。
滇车前【来源】车前科滇车前PlantagoerosaWall.，以种子、全草入药。【功能主治】清热利尿，祛痰，凉血，解毒。用于水肿尿少，热淋涩痛，暑湿泻痢，痰热咳嗽，吐血衄血，痈肿疮毒。
多叶花椒【来源】为芸香科植物多叶花椒的根。全年可采。【功能主治】散寒，镇痛。
通城虎【来源】马兜铃科植物通城虎AristolochiafordianaHemsl.，以根入药。夏秋采集，洗净切片晒干。【功能主治】祛风止痛，解毒消肿。用于胃痛，风湿骨痛，跌打损伤，毒蛇咬伤。
发明内容
本发明旨在提供一种治疗过敏性紫癜性肾炎的中药，通过选择合适的药材及其配比，达到安全有效治愈过敏性紫癜性肾炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗过敏性紫癜性肾炎的中药，其特征在于，由以下重量配比的药材制备而成：枫荷梨10份、大叶狼豆柴14份、丁香罗勒14份、大叶南苏12份、透骨草10份、方叶五月茶12份、肥猪苗20份、飞来蓝14份、红石耳16份、蝶兰22份、东北蛔蒿8份、苔水花15份、芦子兰14份、复羽叶栾树10份、对生耳蕨14份、地涌金莲16份、臭黄荆根12份、费菜10份、法半夏16份、滇车前12份、多叶花椒16份、通城虎15份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2011年2月-2012年12月间共收集119例过敏性紫癜性肾炎的门诊患者，年龄37-63岁，病程1-6年。随机分为：治疗组86例，空白组33例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程30天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程30天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，实验室检查正常，愈后观察三个月未见复发。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) | 不良反应例 |
| 治疗组 | 86 | 20（23.2%） | 48（55.8%) | 18（20.9%) | 79% | 0 |
| 空白组 | 33 | 0 | 6（18.2%） | 27（81.8%） | 18.2% | 0 |
可见，本发明制得的药物能够安全有效治疗过敏性紫癜性肾炎。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：枫荷梨10克、大叶狼豆柴14克、丁香罗勒14克、大叶南苏12克、透骨草10克、方叶五月茶12克、肥猪苗20克、飞来蓝14克、红石耳16克、蝶兰22克、东北蛔蒿8克、苔水花15克、芦子兰14克、复羽叶栾树10克、对生耳蕨14克、地涌金莲16克、臭黄荆根12克、费菜10克、法半夏16克、滇车前12克、多叶花椒16克、通城虎15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗过敏性紫癜性肾炎。口服，每日分早晚两次服用。
具体实施例2
称取：枫荷梨10克、大叶狼豆柴14克、丁香罗勒14克、大叶南苏12克、透骨草10克、方叶五月茶12克、肥猪苗20克、飞来蓝14克、红石耳16克、蝶兰22克、东北蛔蒿8克、苔水花15克、芦子兰14克、复羽叶栾树10克、对生耳蕨14克、地涌金莲16克、臭黄荆根12克、费菜10克、法半夏16克、滇车前12克、多叶花椒16克、通城虎15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗过敏性紫癜性肾炎。口服，每日分早晚两次服用。
具体实施例3
称取：枫荷梨10克、大叶狼豆柴14克、丁香罗勒14克、大叶南苏12克、透骨草10克、方叶五月茶12克、肥猪苗20克、飞来蓝14克、红石耳16克、蝶兰22克、东北蛔蒿8克、苔水花15克、芦子兰14克、复羽叶栾树10克、对生耳蕨14克、地涌金莲16克、臭黄荆根12克、费菜10克、法半夏16克、滇车前12克、多叶花椒16克、通城虎15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗过敏性紫癜性肾炎。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗过敏性紫癜性肾炎的中药，其特征在于，由以下重量配比的药材制备而成：枫荷梨10份、大叶狼豆柴14份、丁香罗勒14份、大叶南苏12份、透骨草10份、方叶五月茶12份、肥猪苗20份、飞来蓝14份、红石耳16份、蝶兰22份、东北蛔蒿8份、苔水花15份、芦子兰14份、复羽叶栾树10份、对生耳蕨14份、地涌金莲16份、臭黄荆根12份、费菜10份、法半夏16份、滇车前12份、多叶花椒16份、通城虎15份。
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1279961A (zh) * | 2000-06-29 | 2001-01-17 | 耿铁 | 肾复康丸 |
| CN1682982A (zh) * | 2005-02-22 | 2005-10-19 | 黄资源 | 一种治疗慢性肾病、肾功能不全的益肾抗衰丸 |
| CN102836393A (zh) * | 2012-10-15 | 2012-12-26 | 赵如风 | 一种透水活肾细胞再生疗法治疗慢性肾炎的药物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1279961A (zh) * | 2000-06-29 | 2001-01-17 | 耿铁 | 肾复康丸 |
| CN1682982A (zh) * | 2005-02-22 | 2005-10-19 | 黄资源 | 一种治疗慢性肾病、肾功能不全的益肾抗衰丸 |
| CN102836393A (zh) * | 2012-10-15 | 2012-12-26 | 赵如风 | 一种透水活肾细胞再生疗法治疗慢性肾炎的药物 |
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