CN103603182A - Soluble stanching gauze and preparation method thereof - Google Patents
Soluble stanching gauze and preparation method thereof Download PDFInfo
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- CN103603182A CN103603182A CN201310544115.2A CN201310544115A CN103603182A CN 103603182 A CN103603182 A CN 103603182A CN 201310544115 A CN201310544115 A CN 201310544115A CN 103603182 A CN103603182 A CN 103603182A
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- gauze
- soluble
- preparation
- soluble stanching
- autoclave
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- 238000002360 preparation method Methods 0.000 title abstract description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 19
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract description 18
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 abstract description 11
- 238000005406 washing Methods 0.000 abstract description 10
- 239000002250 absorbent Substances 0.000 abstract description 9
- 230000002745 absorbent Effects 0.000 abstract description 9
- 230000002439 hemostatic effect Effects 0.000 abstract description 7
- 229920000609 methyl cellulose Polymers 0.000 abstract description 5
- 239000001923 methylcellulose Substances 0.000 abstract description 5
- 239000011265 semifinished product Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 4
- 239000008280 blood Substances 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 4
- 238000005520 cutting process Methods 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 230000035876 healing Effects 0.000 abstract description 2
- 206010016807 Fluid retention Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229940050176 methyl chloride Drugs 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 206010052428 Wound Diseases 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 238000006266 etherification reaction Methods 0.000 description 4
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002696 acid base indicator Substances 0.000 description 2
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 2
- 229940106681 chloroacetic acid Drugs 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N aldehydo-N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- SOIFLUNRINLCBN-UHFFFAOYSA-N ammonium thiocyanate Chemical compound [NH4+].[S-]C#N SOIFLUNRINLCBN-UHFFFAOYSA-N 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 238000004380 ashing Methods 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- NEHMKBQYUWJMIP-OUBTZVSYSA-N chloromethane Chemical group Cl[13CH3] NEHMKBQYUWJMIP-OUBTZVSYSA-N 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002505 iron Chemical class 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000010494 opalescence Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000012286 potassium permanganate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 231100000004 severe toxicity Toxicity 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 239000009306 yunnan baiyao Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a hemostatic medicament and in particular relates to soluble stanching gauze and a preparation method thereof. The soluble stanching gauze comprises methylcellulose generated by reaction of absorbent gauze, sodium hydroxide and methyl chloride in an isopropanol solvent in a weight ratio of 1 to 1 to 1.2. The preparation method comprises the following steps: washing by water, alkalifying, etherifying, washing by hot water, neutralizing and drying to prepare a semi-finished product; checking to ensure that the semi-finished product is qualified; and weighing, cutting and packaging. The soluble stanching gauze provided by the invention is good in moisture absorptivity, quickly absorbs blood for expansion and dissolves the blood after meeting the blood and can form a covering together with blood clots, and dissolving methylcellulose is high in water-retention rate, so that the wettability of the surface of a wound is kept, the tissue healing speed can be increased, and the effects of quickly and effectively stopping bleeding and protecting the surface of a wound are achieved.
Description
Technical field
The present invention relates to field of medicaments, refer to especially a kind of soluble stanching gauze and preparation method thereof.
Background technology
For the hemostatic agent of operation and traumatic bleeding, be generally the method for injection and external application at present, the external application hemostatic anthemorrhagic speeds such as hemostatic early, Yunnan Baiyao are slower, DeGrain; In recent years take the hemostatic that shrimp shell is raw material, can stop blooding rapidly, but complex process, cost is higher.
Hemostatic gauze is widely used at medicine and hygiene fields, but while using gauze can with wound adhesion, easily cause secondary insult, and the refuse after using pollutes the environment.For the problems referred to above, at the beginning of the nineties, soluble stanching gauze comes out successively.If China Patent No. is 91110511 and 9810676 patent of invention, various wounds can be clogged, be covered to the soluble gauze providing, promote that blood platelet condenses, reach hemostasis object, but after using, need to wash off with physiological saline or distilled water, can not be absorbed by the body and can not solve the problem of post-operation adhesion.
Simultaneously the hemostatic gauze of these patents all will be used chloroacetic acid as raw material in preparation process, and chloroacetic acid has severe toxicity, not only high to manufacture equipment requirement, and that also can give operating personnel healthyly brings harm.
Summary of the invention
In view of this, main purpose of the present invention is to provide a kind of soluble stanching gauze that can stop blooding rapidly and have no side effect and preparation method thereof.
Soluble stanching gauze provided by the invention, comprises and by absorbent gauze, NaOH and chloromethane, in isopropanol solvent, is reacted the methylcellulose generating; The weight ratio of above-mentioned three kinds of material compositions is 1:1:1.2.
Preferably, every soluble stanching gauze weighs 1.0 grams, and 0.8 gram, 0.6 gram, or 0.4 gram, Aspect Ratio is 10:7,8:6 or 3:2.
Preferably, the fiber grain of described soluble gauze is less than 100nm.
The preparation method of soluble stanching gauze provided by the invention, comprises the steps:
(1) gauze and purified water are added by the proportion of 1:100, wash 1 hour;
(2) NaOH of gauze and 45-50% and aqueous isopropanol are joined in autoclave, temperature is 25 ℃, and pressure is 5 atmospheric pressure, and heating 0.5-1.5 hour, alkalizes;
(3) chloromethane is joined in autoclave, temperature is 85 ℃, heating 3-5 hour, and pressure is 5 atmospheric pressure, carries out etherificate, discharges afterwards reactant liquor;
(4) hot water of 75 ℃ is joined in autoclave, rinsing 20-40 minute, discharges washing lotion afterwards;
(5) hot water of 75 ℃ is joined in autoclave, add after acid-base indicator, add concentrated hydrochloric acid, neutralize, limit liquid feeding limit rinsing, until reactant liquor is neutrality, discharges washing lotion;
(6) hot water of 75 ℃ is joined in autoclave, rinsing 20-40 minute, removes the salt that neutralization generates;
(7) reacted gauze is dried, temperature is 40-50 ℃;
(8) after the dried inspection of semifinished product is qualified, weigh, cut out, pack.
Preferably, the weight ratio of absorbent gauze, NaOH and three kinds of material compositions of chloromethane is 1:1:1.2, and the weight ratio of isopropyl alcohol and absorbent gauze, NaOH is 2:1:1.
Preferably, in described step (1), after gauze washing, can naturally place 1-2 hour.
Preferably, the phenolphthalein that the acid-base indicator in described step (5) is 1% and 1% bromjophenol blue.
Soluble stanching gauze good hygroscopicity provided by the invention, meet after blood, absorbing rapidly expands dissolves, can form covering with clot, and the methylcellulose water retention rate dissolving is high, the wettability that has kept the surface of a wound, can accelerate the speed of organization healing, reaches the effect of rapidly and effectively hemostasis, the protection surface of a wound; Not containing any pharmaceutical compositions, for having no side effect after absorption of human body.Processing is processed and is made gauze fiber become ultra microstructure, and dissolubility is better, is easy to absorb.The present invention can be applicable to operation, trauma hemostasis, tooth extraction, skin surgery art and protection wound face.
The preparation method of soluble stanching gauze provided by the invention, technique is simple, in preparation process, adopt chloromethanes to replace monoxone of the prior art, the toxicity of raw material is reduced greatly, make preparation process bring harm to reduce to the healthy of operating personnel; The solvent isopropyl alcohol of alkalization, etherification procedure, after etherification procedure completes, reclaims, and has not only reduced cost, has also reduced the pollution to environment; Because methylcellulose is insoluble to hot water, the product after etherification completes can be removed alkali lye and salinity with hot wash, makes last handling process very simple, cost-saving.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1
1,13.2kg NaOH is mixed with to 50% solution by purified water, separately prepares the isopropyl alcohol of 26.4kg, and prepare 15.8kg chloromethanes.
2,13.2kg absorbent gauze is mixed by the proportion of 1:100 with purified water, absorbent gauze is turned around on winding up roller cylinder, wash 1 hour, naturally place 1.5 hours.
3, in autoclave, add the absorbent gauze through washing, go out the air in still, and under vacuum, add sodium hydroxide solution and the isopropyl alcohol preparing with nitrogen replacement, be heated to 25 ℃, pressure is 5 atmospheric pressure, reacts 1 hour.
4, segmentation subsequently adds chloromethanes in autoclave, is heated to 85 ℃, and pressure is 5 atmospheric pressure, reacts 5 hours, carries out etherificate, and reaction finishes rear cooling, discharges afterwards reactant liquor.Wherein unreacted chloromethanes recycles in next etherification reaction.
5, the hot water of 75 ℃ is joined in autoclave, rinsing absorbent gauze, rinsing 25 minutes, discharges washing lotion.
6, the hot water of 75 ℃ is joined in autoclave, rinsing absorbent gauze adds the bromjophenol blue of 1% phenolphthalein and 1% simultaneously, add afterwards concentrated hydrochloric acid, neutralize, limit liquid feeding limit rinsing, until reactant liquor is yellow, recording solution pH value is 6.5 left and right, discharges washing lotion.
7, the hot water of 75 ℃ is joined in retort, rinsing 25 minutes, removes the salt that neutralization generates.
8, ventilation in advance, makes equipment be preheated to 40-50 ℃, and reacted gauze is dried, and maintenance temperature is 40-50 ℃; The folding 4-5 layer of gauze is divided on baking oven, with stainless steel rider horizontal pushing pressure, made gauze smooth; Within every 10 minutes, turn over once also pushing of cloth, until gauze is dry.
9, dried semi-finished product are tested.
10, the semi-finished product gauze being up to the standards is folding, cutting, weighs, and by average sheet, weighs 0.8 gram, is cut into the required area of hemostatic gauze, long: wide is the ratio of 10:7; In cutting process, need weigh once every 20 minutes, discovery deviation is adjusted in time.It is 10,000 tablet recipe amounts that the present embodiment provides consumption.
Embodiment 2
NaOH is mixed with to 45% concentration, other steps are identical with embodiment 1.
Embodiment 3
The etherificate time is adjusted into 3 hours, and other steps are identical with embodiment 1.
Embodiment 4
The soluble stanching gauze of the present invention that embodiment 1～2 is made carries out medicine and detects test, and result is as follows:
1, dissolubility detects: get soluble stanching gauze 0.5g of the present invention, add warm water 100ml and dissolve, solution is the translucent sticky colloid of colourless or micro-yellow, and micro-band opalescence, without insoluble fibre.
2, pH value detects: get soluble stanching gauze 0.5g of the present invention, add after water 100ml dissolving, record PH within the scope of 6.0-8.0.
3, chloride content detects: get soluble stanching gauze 0.10g of the present invention, add after water 250ml dissolving, tepor stirs and makes it to dissolve, filter, cooling, get filtrate 12.5ml, with the contrast solution comparison that standard sodium chloride solution 5ml makes, chloride content is lower than 1.0%.
4, the content detection of molysite: get soluble stanching gauze 1.0g of the present invention, put in crucible, blazing to cooling after ashing, adding watery hydrochloric acid 5ml makes it to dissolve, add water appropriate, filter a small amount of water washing filter and residue, merging filtrate and washing lotion, move in 50ml Na Shi colorimetric cylinder, drip potassium permanganate test solution when being purple and not taking off, add ammonium thiocyanate test solution 5ml, be diluted with water to 50ml, shake up, as colour developing, with the contrast solution comparison that standard iron salt solutions 15ml makes with Same Way, molysite content is lower than contrast.
5, aseptic detection: preparation process of the present invention strictly observes sterile working standard, up to specification after testing.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. a soluble stanching gauze, is characterized in that, comprises and by absorbent gauze, NaOH and chloromethane, in isopropanol solvent, is reacted the methylcellulose generating; The weight ratio of above-mentioned three kinds of material compositions is 1:1:1.2.
2. soluble stanching gauze as claimed in claim 1, is characterized in that, every described of soluble stanching gauze is heavy 1.0 grams, 0.8 gram, and 0.6 gram, or 0.4 gram.
3. soluble stanching gauze as claimed in claim 1, is characterized in that, described soluble stanching gauze Aspect Ratio is 10:7,8:6 or 3:2.
4. soluble stanching gauze as claimed in claim 1, is characterized in that, the fiber grain of described soluble gauze is less than 100nm.
5. a preparation method for soluble stanching gauze, is characterized in that, comprises the steps:
(1) gauze and purified water are added by the proportion of 1:100, wash 1 hour;
(2) sodium hydroxide solution of gauze and 45-50% and isopropyl alcohol are joined in autoclave, temperature is 25 ℃, and pressure is 5 atmospheric pressure, and heating 0.5-1.5 hour, alkalizes;
(3) chloromethane is joined in autoclave, temperature is 85 ℃, heating 3-5 hour, and pressure is 5 atmospheric pressure, carries out etherificate, discharges afterwards reactant liquor;
(4) hot water of 75 ℃ is joined in autoclave, rinsing 20-40 minute, discharges washing lotion afterwards;
(5) hot water of 75 ℃ is joined in autoclave, add after acid-base indicator, add concentrated hydrochloric acid, neutralize, limit liquid feeding limit rinsing, until reactant liquor is neutrality, discharges washing lotion;
(6) hot water of 75 ℃ is joined in autoclave, rinsing 20-40 minute, removes the salt that neutralization generates;
(7) reacted gauze is dried, temperature is 40-50 ℃;
(8) after the dried inspection of semifinished product is qualified, weigh, cut out, pack.
6. the preparation method of a kind of soluble gauze as claimed in claim 5, is characterized in that, the weight ratio of absorbent gauze, NaOH and three kinds of material compositions of chloromethane is 1:1:1.2, and the weight ratio of isopropyl alcohol and absorbent gauze, NaOH is 2:1:1.
7. the preparation method of a kind of solubility yarn as claimed in claim 5 and cloth, is characterized in that, in described step (1), after gauze washing, can naturally place 1-2 hour.
8. the preparation method of a kind of soluble gauze as claimed in claim 5, is characterized in that, the phenolphthalein that the acid-base indicator in described step (5) is 1% and 1% bromjophenol blue.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310544115.2A CN103603182B (en) | 2013-11-05 | 2013-11-05 | Soluble stanching gauze and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310544115.2A CN103603182B (en) | 2013-11-05 | 2013-11-05 | Soluble stanching gauze and preparation method thereof |
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| CN103603182A true CN103603182A (en) | 2014-02-26 |
| CN103603182B CN103603182B (en) | 2016-01-13 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105862388A (en) * | 2015-01-21 | 2016-08-17 | 重庆联佰博超医疗器械有限公司 | Preparation method of hydroxy propyl cellulose used for haemostasis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1181980A (en) * | 1996-06-28 | 1998-05-20 | 庄臣及庄臣医药有限公司 | Bioabsorbable medical devices from oxidized polysaccharides |
| CN1505530A (en) * | 2001-04-30 | 2004-06-16 | ������֯��ѧ�о��� | Water soluble cellulose etherified derivates styptic materials |
| CN101491688A (en) * | 2008-01-23 | 2009-07-29 | 王学洲 | Soluble stanching gauze and preparation method thereof |
| JP2010110638A (en) * | 2004-10-14 | 2010-05-20 | L'oreal Sa | Medium configured to be impregnated with liquid, and kit including such medium |
-
2013
- 2013-11-05 CN CN201310544115.2A patent/CN103603182B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1181980A (en) * | 1996-06-28 | 1998-05-20 | 庄臣及庄臣医药有限公司 | Bioabsorbable medical devices from oxidized polysaccharides |
| CN1505530A (en) * | 2001-04-30 | 2004-06-16 | ������֯��ѧ�о��� | Water soluble cellulose etherified derivates styptic materials |
| JP2010110638A (en) * | 2004-10-14 | 2010-05-20 | L'oreal Sa | Medium configured to be impregnated with liquid, and kit including such medium |
| CN101491688A (en) * | 2008-01-23 | 2009-07-29 | 王学洲 | Soluble stanching gauze and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105862388A (en) * | 2015-01-21 | 2016-08-17 | 重庆联佰博超医疗器械有限公司 | Preparation method of hydroxy propyl cellulose used for haemostasis |
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