CN103599559A - Polylactic acid modified medical operation incision adhesion agent - Google Patents
Polylactic acid modified medical operation incision adhesion agent Download PDFInfo
- Publication number
- CN103599559A CN103599559A CN201310524107.1A CN201310524107A CN103599559A CN 103599559 A CN103599559 A CN 103599559A CN 201310524107 A CN201310524107 A CN 201310524107A CN 103599559 A CN103599559 A CN 103599559A
- Authority
- CN
- China
- Prior art keywords
- polylactic acid
- parts
- acid modified
- medical operation
- adhesion agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000747 poly(lactic acid) Polymers 0.000 title claims abstract description 25
- 239000004626 polylactic acid Substances 0.000 title claims abstract description 25
- 239000003795 chemical substances by application Substances 0.000 title abstract description 6
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims abstract description 20
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 claims abstract description 20
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 239000000853 adhesive Substances 0.000 claims description 15
- 230000001070 adhesive effect Effects 0.000 claims description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 9
- 239000002994 raw material Substances 0.000 abstract description 2
- 229920001651 Cyanoacrylate Polymers 0.000 abstract 1
- -1 acrylic ester Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- JJJFUHOGVZWXNQ-UHFFFAOYSA-N enbucrilate Chemical compound CCCCOC(=O)C(=C)C#N JJJFUHOGVZWXNQ-UHFFFAOYSA-N 0.000 abstract 1
- 229950010048 enbucrilate Drugs 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 238000011957 budget and coverage analysis Methods 0.000 description 7
- 239000003292 glue Substances 0.000 description 3
- 239000002390 adhesive tape Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000004394 hip joint Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
A preparation method of a polylactic acid modified medical operation incision adhesion agent is characterized in that the adhesion agent comprises the components by weight: 100-120 parts of n-butyl cyanoacrylate, 1-3 parts of hydroquinone, 1-2 parts of sulfur dioxide, 1-3 parts of polylactic acid, 1-3 parts of cis-butenedioic anhydride, and 0.5-1 part of acrylic ester. The materials are mixed uniformly to obtain the product. The adhesion agent has the advantages of easily obtained raw materials, low cost, green environmental protection, convenient use, and good effect.
Description
Technical field
The invention belongs to a kind of medical material.
Background technology
The bonding operative incision of glue have healing fast, infect less, cicatrix is little, pain is light, appearance looks elegant, the feature such as need not take out stitches.
Through Chinese publication retrieval, do not find the scheme identical with present patent application.
Summary of the invention:
The object of the invention is to; A kind of polylactic acid modified medical operation otch adhesive and preparation method thereof is proposed.
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, and by BCA 100-120 part, hydroquinone 1-3 part, sulfur dioxide 1-2 part, polylactic acid 1-3 part, maleic anhydride 1-3 part, acrylate 0.5-1 part forms.
Polylactic acid modified medical operation otch adhesive preparation method of the present invention, is characterized in that: by weight, and by BCA 100-120 part, hydroquinone 1-3 part, sulfur dioxide 1-2 part, polylactic acid 1-3 part, maleic anhydride 1-3 part, acrylate 0.5-1 part forms; Mixing of materials is evenly obtained to product.
Polylactic acid modified medical operation otch adhesive products of the present invention, can preserve 12 months in lucifuge, lower than 15 ℃.
The present invention compared with prior art its beneficial effect is: performance is more excellent, and storage life reaches 12 months, far above the BCA class medical adhesive storage life of 3 months of prior art.
The specific embodiment:
Below in conjunction with embodiment, the invention will be further described, but embodiments of the present invention are not limited to this.
Polylactic acid modified medical operation otch adhesive of the present invention, raw materials usedly buys acquisition.
Embodiment 1
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, and by BCA 100-120 part, hydroquinone 1-3 part, sulfur dioxide 1-2 part, polylactic acid 1-3 part, maleic anhydride 1-3 part, acrylate 0.5-1 part forms; Mixing of materials is evenly obtained to product.At in lucifuge, lower than 15 ℃, can preserve 12 months.
Embodiment 2
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, by 100 parts of BCAs, 1 part of hydroquinone, 1 part of sulfur dioxide, 1 part of polylactic acid, 1 part of maleic anhydride, 0.5 part of composition of acrylate; Mixing of materials is evenly obtained to product.At in lucifuge, lower than 15 ℃, can preserve 12 months.
Embodiment 3
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, by 120 parts of BCAs, 3 parts of hydroquinone, 2 parts of sulfur dioxide, 3 parts of polylactic acid, 3 parts of maleic anhydrides, 1 part of composition of acrylate; Mixing of materials is evenly obtained to product.At in lucifuge, lower than 15 ℃, can preserve 12 months.
Embodiment 4
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, by 100 parts of BCAs, 3 parts of hydroquinone, 1 part of sulfur dioxide, 3 parts of polylactic acid, 1 part of maleic anhydride, 1 part of composition of acrylate; Mixing of materials is evenly obtained to product.At in lucifuge, lower than 15 ℃, can preserve 12 months.
Embodiment 5
Polylactic acid modified medical operation otch adhesive of the present invention, is characterized in that: by weight, by 120 parts of BCAs, 1 part of hydroquinone, 2 parts of sulfur dioxide, 1 part of polylactic acid, 3 parts of maleic anhydrides, 0.5 part of composition of acrylate; Mixing of materials is evenly obtained to product.At in lucifuge, lower than 15 ℃, can preserve 12 months.
Product standard:
Appearance colorless or micro-yellow transparent liquid
Impurity (phosphorus, sulfur, aldehyde, phenol) is qualified
Purity/% >=99 content
Acid number meets the requirements
At in lucifuge, lower than 15 ℃, can preserve 12 months.
Purposes:
1, soft tissue sticks with glue the purposes of agent: be applicable to replace pin to sew up and make skin wound, mouthful hemostasis, coincideing of operative incision, can not stay clear scar.Also can be used for bonding and the hemostasis of interior liver.Substantially curing in 10s under body temperature, after 4 days, can reach maximum intensity.
2, sclerous tissues sticks with glue the purposes of agent: the adhesive of the reparation of bone, artificial hip joint and bone; Dental caries Plugging is used, bonding dentine;
3, for covering and the protection of various surgical incisions and outer wound mouth; For medical pressure-sensing adhesive tape, operative membrane, otch adhesive tape etc.
Claims (2)
1. a polylactic acid modified medical operation otch adhesive, is characterized in that: by weight, and by BCA 100-120 part, hydroquinone 1-3 part, sulfur dioxide 1-2 part, polylactic acid 1-3 part, maleic anhydride 1-3 part, acrylate 0.5-1 part forms.
2. a polylactic acid modified medical operation otch adhesive preparation method, is characterized in that: by weight, and by BCA 100-120 part, hydroquinone 1-3 part, sulfur dioxide 1-2 part, polylactic acid 1-3 part, maleic anhydride 1-3 part, acrylate 0.5-1 part forms; Mixing of materials is evenly obtained to product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310524107.1A CN103599559A (en) | 2013-10-30 | 2013-10-30 | Polylactic acid modified medical operation incision adhesion agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310524107.1A CN103599559A (en) | 2013-10-30 | 2013-10-30 | Polylactic acid modified medical operation incision adhesion agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103599559A true CN103599559A (en) | 2014-02-26 |
Family
ID=50117861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310524107.1A Pending CN103599559A (en) | 2013-10-30 | 2013-10-30 | Polylactic acid modified medical operation incision adhesion agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103599559A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105251038A (en) * | 2015-10-09 | 2016-01-20 | 中国科学院长春应用化学研究所 | Anti-infection soft tissue medical adhesive and preparation method thereof |
| CN112156221A (en) * | 2020-10-30 | 2021-01-01 | 北京福爱乐科技发展有限公司 | Pyrogen-free biocompatible medical adhesive material and preparation method thereof |
| CN112190753A (en) * | 2020-10-30 | 2021-01-08 | 北京福爱乐科技发展有限公司 | Antibacterial medical adhesive material and preparation method thereof |
| CN112263707A (en) * | 2020-10-30 | 2021-01-26 | 北京福爱乐科技发展有限公司 | Anti-infection medical adhesive material and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3527841A (en) * | 1968-04-10 | 1970-09-08 | Eastman Kodak Co | Alpha-cyanoacrylate adhesive compositions |
| US5328687A (en) * | 1993-03-31 | 1994-07-12 | Tri-Point Medical L.P. | Biocompatible monomer and polymer compositions |
| CN1448187A (en) * | 2002-04-02 | 2003-10-15 | 成都航利生物材料研究所 | Medical surgical adhesive |
-
2013
- 2013-10-30 CN CN201310524107.1A patent/CN103599559A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3527841A (en) * | 1968-04-10 | 1970-09-08 | Eastman Kodak Co | Alpha-cyanoacrylate adhesive compositions |
| US5328687A (en) * | 1993-03-31 | 1994-07-12 | Tri-Point Medical L.P. | Biocompatible monomer and polymer compositions |
| CN1448187A (en) * | 2002-04-02 | 2003-10-15 | 成都航利生物材料研究所 | Medical surgical adhesive |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105251038A (en) * | 2015-10-09 | 2016-01-20 | 中国科学院长春应用化学研究所 | Anti-infection soft tissue medical adhesive and preparation method thereof |
| CN112156221A (en) * | 2020-10-30 | 2021-01-01 | 北京福爱乐科技发展有限公司 | Pyrogen-free biocompatible medical adhesive material and preparation method thereof |
| CN112190753A (en) * | 2020-10-30 | 2021-01-08 | 北京福爱乐科技发展有限公司 | Antibacterial medical adhesive material and preparation method thereof |
| CN112263707A (en) * | 2020-10-30 | 2021-01-26 | 北京福爱乐科技发展有限公司 | Anti-infection medical adhesive material and preparation method thereof |
| CN112190753B (en) * | 2020-10-30 | 2022-03-18 | 北京福爱乐科技发展有限公司 | Antibacterial medical adhesive material and preparation method thereof |
| CN112263707B (en) * | 2020-10-30 | 2022-05-27 | 卫纳塞德(北京)医疗科技有限公司 | Anti-infection medical adhesive material and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140226 |