CN103585596B - Traditional Chinese medicine composition for treating migraine - Google Patents
Traditional Chinese medicine composition for treating migraine Download PDFInfo
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- CN103585596B CN103585596B CN201310488666.1A CN201310488666A CN103585596B CN 103585596 B CN103585596 B CN 103585596B CN 201310488666 A CN201310488666 A CN 201310488666A CN 103585596 B CN103585596 B CN 103585596B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating migraine, belonging to the technical field of Chinese herbal medicines. The traditional Chinese medicine composition is a preparation prepared from the following active ingredients by weight: 11-13g of angelica sinensis, 14-16g of wine fried radix paeoniae alba, 11-13g of ligusticum wallichii, 11-13g of radix bupleuri, 11-13g of rhizoma cyperi, 11-13g of schizonepeta, 11-13g of radix saposhnikoviae, 5-7g of liquorice, 14-16g of scutellaria baicalensis, 11-13g of fructus viticis and 2-4g of ginger. The traditional Chinese medicine composition meets the traditional Chinese medicine differentiation theory in traditional Chinese medicine selection and matching, and has the advantages of simpleness in matching method, rapidness in taking effect, high heal rate, uneasiness to replase and the like. The traditional Chinese medicine composition has the effects of swelling and detoxifying, invigorating the circulation of blood, clearing away heat and toxic materials, scattering wind to relieve pain, relieving migraine, complementing fire and backing to yang, warming the middle warmer to relieve pain, removing dampness to reduce phlegm, widening the middle and relieving mass, relieving fainting to relieve pain, nourishing blood and retaining yin, slowing urgency to relieve pain, calming liver wind, arresting convulsion to relieve pain, alleviating water retention and clearing heat to relieve pain, and warming the middle warmer to scatter gloom.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, being specifically related to a kind of for controlling migrainous Chinese medicine composition.
Background technology
Migraine is a kind of pulsatile headache of recurrent exerbation, belong to the one in numerous headache type, the tendencys such as flash of light, blurred vision, numb limbs and tense tendons are often had before its outbreak, few minutes to 1 hours occurs that side head one jumps a pain of choosing, and aggravate gradually, until after there is Nausea and vomiting, sensation just has and taken a turn for the better, headache relief in peace and quiet, dark surrounds or after sleep, makes patient suffering can't bear.
In migrainous treatment, doctor trained in Western medicine is commonly used the medicine such as pizotifen, amitriptyline to treat, and substantially all has some curative effects, but can only take stopgap measures and can not effect a permanent cure, and the side effect of these medicines is a lot, especially very large to lesions of liver and kidney, just relief of symptoms, cannot play the object of thoroughly curing.
Summary of the invention
It is high that technical problem to be solved by this invention is to provide a kind of cure rate, safe and reliable for controlling migrainous Chinese medicine composition.
Technical problem to be solved by this invention realizes by the following technical solutions:
One is used for controlling migrainous Chinese medicine composition, is made up of the crude drug of following weight,
Radix Angelicae Sinensis 11-13 gram, Radix Paeoniae Alba 14-16 gram, Rhizoma Chuanxiong 11-13 gram, Radix Bupleuri 11-13 gram, Rhizoma Cyperi 11-13 gram, Herba Schizonepetae 11-13 gram, Radix Saposhnikoviae 11-13 gram, Radix Glycyrrhizae 5-7 gram, Radix Scutellariae 14-16 gram, Fructus Viticis 11-13 gram, Rhizoma Zingiberis Recens 2-4 sheet.
The preferred weight of each crude drug is:
Radix Angelicae Sinensis 12 grams, Radix Paeoniae Alba 15 grams, Rhizoma Chuanxiong 12 grams, Radix Bupleuri 12 grams, Rhizoma Cyperi 12 grams, Herba Schizonepetae 12 grams, Radix Saposhnikoviae 12 grams, 6 grams, Radix Glycyrrhizae, Radix Scutellariae 15 grams, Fructus Viticis 12 grams, 3, Rhizoma Zingiberis Recens.
Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets national Chinese crude drug standard.
Another object of the present invention is to provide a kind of method preparing the present composition, comprises the steps,
1) each crude drug is taken by following weight: Radix Angelicae Sinensis 12 grams, Radix Paeoniae Alba 15 grams, Rhizoma Chuanxiong 12 grams, Radix Bupleuri 12 grams, Rhizoma Cyperi 12 grams, Herba Schizonepetae 12 grams, Radix Saposhnikoviae 12 grams, 6 grams, Radix Glycyrrhizae, Radix Scutellariae 15 grams, Fructus Viticis 12 grams, 3, Rhizoma Zingiberis Recens;
2) above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.
1, pharmacology analysis:
Radix Angelicae Sinensis: control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.
The Radix Paeoniae Alba: nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.
Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian.Point out in " book on Chinese herbal medicine justice ", headache bulge of the ear can be treated, the diseases such as dizzy vomiting, distending pain over the hypochondrium.
Rhizoma Cyperi: treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.
Herba Schizonepetae: cure mainly cold, fever, headache, laryngopharynx swelling and pain, apoplexy locked mouth, spit blood, epistaxis, has blood in stool; Metrorrhagia, puerperal blood faints; Carbuncle, skin ulcer scabies, scrofula.
Radix Saposhnikoviae: cure mainly affection of exogenous wind-cold, headache, dizzy, stiffness of the nape, anemofrigid-damp arthralgia, joint is ached, and extremity contraction is anxious, tetanus.
Radix Glycyrrhizae: cure mainly weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, infantile convulsion; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.
Radix Scutellariae: cure mainly high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, tell, be defeated in battle, collapse, leak, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.
Fructus Viticis: " book on Chinese herbal medicine newly organized ": Fructus Viticis, bitter in the mouth, pungent, sweet, temperature, to be slightly cold, the YIN aspect of YANG is nontoxic.Enter Taiyang channel.Main muscles and bones cold and heat, arthralgia chiefly caused by damp pathogen contracture, herbal classic is had a headache, and head heavy dusk is vexed, sharp joint, long hair, logical nine orifices, debug, and loose wind is excessive, improving eyesight, and tinnitus is only.
Rhizoma Zingiberis Recens: warming middle-JIAO nourishes blood, cold-dispelling pain-relieving, cures mainly cold, and vomiting, phlegm retention, breathes with cough, and distension is had loose bowels.
2, usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.Instruction: decoction, gets an auxiliary medicine, is boiled into decoction, and every day one is secondary, within 7 days, is a course for the treatment of.
3, the present composition has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.Its test method and result of the test are distinguished as follows:
1) animal acute toxicity test is carried out to decoction prepared by the present invention:
Medicine: the crude drug used by the present invention is bought from common Chinese shop and obtained, and its specification meets national Chinese crude drug standard.
Experimental animal: white mice, body weight is at about 50g, and male and female Stochastic choice, is bought by market.
Method and result: get white mice 30, hungry 20 hours, feeding 50ml by filling with several times every every day, feeding one week continuously, observing 10 days, and mice is movable normal, non-toxic reaction, without dead.Show that oral liquid is without acute toxicity, clinical medicine dose safety.
2) long-term toxicity test for animals is carried out to decoction prepared by the present invention:
Experimental animal: rat, body weight is at 120-130g, and male and female Stochastic choice, is bought by market.
Method and result: get rat 20, be divided into 2 groups, often organize 10, wherein the 1st group as administration group, 40-50ml is fed by filling with several times every every day, 2nd group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, equal non-toxic reaction, a kind of safe drugs.
4, diagnostic criteria
1) how repeatedly clinical diagnosis: headache mostly is inclined side, generally continue 4 ~ 72 hours, with Nausea and vomiting.
2) in order to verify clinical efficacy, this prescription is tried out in Affiliated Hospital of Chinese medicine institute first of Anhui Province respectively, and random selecting is 50 routine migraine patients wherein.
3) Therapeutic Method: according to drug ratios of the present invention, takes raw material (dose), and the foundation usually method of decocting medicinal herbs obtains decoction, and every day one is secondary, and taking 7 days is a course for the treatment of, the shortest 2 courses for the treatment of, the longest half a year.
4) efficacy determination:
Recovery from illness: migraine and related symptoms all disappear, and do not affect orthobiosis and work;
Effective: migraine and related symptoms disappear substantially, after treatment, symptom obviously alleviates, and does not affect daily life and work;
Effective: related symptoms and sign are improved, but unstable condition, there is recurrence after drug withdrawal;
Invalid: to treat rear symptom, sign compared with before treatment without any change;
Concrete therapeutic outcome is see table 1.
Table 1
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| 50 | 5 | 30 | 13 | 2 | 96 |
5, points for attention:
1. diet should be light, gives up alcohol and pungent, raw and cold, greasy food.
2. child, women breast-feeding their children, elderly and infirm should take under doctor instructs.
3. driver, work high above the ground person are cautious use of.
4. strictly take by usage and dosage, this medicine should not be taken for a long time in a large number.
5. pair this medicine and alcohol intolerance person forbidding, allergic constitution person be cautious use of.
6. prohibit the use when this property of drug changes.
7. please this medicine is placed on the place that child can not contact.
8. as used other medicines, please Ref Dr or pharmacist before using this medicine.
The invention has the beneficial effects as follows: the present invention selects at Chinese crude drug and compatibility meets Chinese medical discrimination theory, and compound method simply, and have rapid-action, cure rate is high, not easily the advantage such as recurrence.Subduing swelling and detoxicating, blood circulation promoting and dispersing pathogen accumulation, heat-clearing and toxic substances removing, loose wind relieves the pain, only migraine and general headache, and mend fiery recuperating depleted YANG, warming middle-JIAO relieves the pain, drying dampness to eliminate phlegm, and alleviating distention in middle-JIAO disappears painful abdominal mass, and relieving fainting relieves the pain, and nourish blood yin fluid astringing, relieving spasm to stop pain, suppressing the hyperactive liver to relieve the wind syndrome, arresting convulsion pain relieving, diuretic heat clearing away relieving fainting, warming middle-JIAO dissipating depression of QI.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Take each crude drug: Radix Angelicae Sinensis 12 grams, Radix Paeoniae Alba 15 grams, Rhizoma Chuanxiong 12 grams, Radix Bupleuri 12 grams, Rhizoma Cyperi 12 grams, Herba Schizonepetae 12 grams, Radix Saposhnikoviae 12 grams, 6 grams, Radix Glycyrrhizae, Radix Scutellariae 15 grams, Fructus Viticis 12 grams, 3, Rhizoma Zingiberis Recens.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, every day one is secondary, and taking 7 days is a course for the treatment of.
Embodiment 2
Each crude drug is taken: Radix Angelicae Sinensis 13 grams, Radix Paeoniae Alba 16 grams, Rhizoma Chuanxiong 13 grams, Radix Bupleuri 13 grams, Rhizoma Cyperi 13 grams, Herba Schizonepetae 13 grams, Radix Saposhnikoviae 13 grams, 7 grams, Radix Glycyrrhizae, Radix Scutellariae 16 grams, Fructus Viticis 13 grams, 4, Rhizoma Zingiberis Recens by following parts by weight.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, every day one is secondary, and taking 7 days is a course for the treatment of.
Embodiment 3
Each crude drug is taken: Radix Angelicae Sinensis 11 grams, Radix Paeoniae Alba 14 grams, Rhizoma Chuanxiong 11 grams, Radix Bupleuri 11 grams, Rhizoma Cyperi 11 grams, Herba Schizonepetae 11 grams, Radix Saposhnikoviae 11 grams, 5 grams, Radix Glycyrrhizae, Radix Scutellariae 14 grams, Fructus Viticis 11 grams, 2, Rhizoma Zingiberis Recens by following parts by weight.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, every day one is secondary, and taking 7 days is a course for the treatment of.
Model case:
Case 1
Hu, female, 62 years old, retired cadre, brick people from market town, Jieshou City, Anhui Province.Because of direct stimulation burst side local pain, have a headache for pulsation or drilling pain, simultaneously with anorexia, vomiting, feel sick, after taking 3 courses for the treatment of of decoction of the present invention, symptom alleviates, after take again 6 courses for the treatment of continuously, fully recover latter 1 year with anti-, do not recur.
Case 2
Still so-and-so, female, 36 years old, peasant, Dai Qiao people from town, Jieshou City, Anhui Province.Because transition is worried about in fatigue, occur migraine, through looking into, all muscle tones of cranium increase to cause lastingly has a headache for non-pulsation, tightens sense, sense of heaviness.After taking 4 courses for the treatment of of decoction of the present invention, symptom alleviates, after take again 6 courses for the treatment of continuously, fully recover latter 1 year with anti-, do not recur.
Case 3
Just so-and-so, male, 67 years old, peasant, Dai Qiao people from town, Jieshou City, Anhui Province.Recent years, sleep quality was always very poor, and through being everlasting, headache appears in midnight, and daytime does not have spirit.Take the present invention after 2 months, sleep improves, and headache syndromes disappears substantially.After take again 6 courses for the treatment of continuously, fully recover latter 1 year with anti-, do not recur.
Case 4
Journey so-and-so, man, 28 years old, corporate business personnel, went to work in Hefei City, Anhui Province.Because pressure is large, body constitution is poor, often occurs migraine phenomenon, annoyings always, enjoy and decoct.Take the present invention after 2 months, sleep improves, and headache syndromes disappears substantially.After take again 6 courses for the treatment of continuously, fully recover latter 1 year with anti-, do not recur.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (3)
1. one kind for controlling migrainous Chinese medicine composition, it is characterized in that, be made up of the crude drug of following weight: Radix Angelicae Sinensis 11-13 gram, Radix Paeoniae Alba 14-16 gram, Rhizoma Chuanxiong 11-13 gram, Radix Bupleuri 11-13 gram, Rhizoma Cyperi 11-13 gram, Herba Schizonepetae 11-13 gram, Radix Saposhnikoviae 11-13 gram, Radix Glycyrrhizae 5-7 gram, Radix Scutellariae 14-16 gram, Fructus Viticis 11-13 gram, Rhizoma Zingiberis Recens 2-4 sheet.
2. one according to claim 1 is used for controlling migrainous Chinese medicine composition, it is characterized in that, be made up of the crude drug of following weight: Radix Angelicae Sinensis 12 grams, Radix Paeoniae Alba 15 grams, Rhizoma Chuanxiong 12 grams, Radix Bupleuri 12 grams, Rhizoma Cyperi 12 grams, Herba Schizonepetae 12 grams, Radix Saposhnikoviae 12 grams, 6 grams, Radix Glycyrrhizae, Radix Scutellariae 15 grams, Fructus Viticis 12 grams, 3, Rhizoma Zingiberis Recens.
3. prepare a method for Chinese medicine composition described in any one of claim 1 or 2, it is characterized in that, comprise the following steps:
A. each taste crude drug is taken by weight described in prescription;
B. above-mentioned each taste material medicine is mixed that being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.
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| CN201310488666.1A CN103585596B (en) | 2013-10-18 | 2013-10-18 | Traditional Chinese medicine composition for treating migraine |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104306529A (en) * | 2014-09-09 | 2015-01-28 | 宋永花 | Traditional Chinese medicine for treating migraine |
| CN108465020A (en) * | 2018-03-30 | 2018-08-31 | 董志峰 | Treat the Chinese medicine composition and preparation method thereof of migraines |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1270043A (en) * | 2000-01-27 | 2000-10-18 | 冀承环 | Medicine for treating hemicrania |
| CN102125643A (en) * | 2010-01-15 | 2011-07-20 | 王守忠 | Traditional Chinese medicinal capsules for treating headache |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1270043A (en) * | 2000-01-27 | 2000-10-18 | 冀承环 | Medicine for treating hemicrania |
| CN102125643A (en) * | 2010-01-15 | 2011-07-20 | 王守忠 | Traditional Chinese medicinal capsules for treating headache |
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