CN103585517A - Drug composition for treating hepatitis and cholecystitis and preparation method thereof - Google Patents
Drug composition for treating hepatitis and cholecystitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a drug composition for treating hepatitis and cholecystitis and a preparation method thereof. The drug composition comprises the following traditional Chinese medicinal materials or the extracts of the materials in parts by weight: 100-200 parts of dandelion, 15-30 parts of liquorice, 70-150 parts of semen coicis, 30-80 parts of pericarpium citri reticulatae viride, 30-80 parts of radix bupleuri, 100-150 parts of artemisia apiacea and 100-150 parts of porcine bile. The drug composition can be used for treating the hepatitis and the cholecystitis at the same time according to the common pathogenesis of the hepatitis and the cholecystitis, and has a good treatment effect in comparison with adopted antisepsis and anti-inflammation drugs or added sedative and analgesic drugs.
Description
[technical field]
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of hepatitis, cholecystitis and preparation method thereof.
[background technology]
Hepatitis, cholecystitis are a kind of commonly encountered diseases and frequently-occurring disease.Hepatitis is often caused by hepatitis virus, is a kind of systemic disease of liver injury as master of take.On pathology, take hepatic necrosis and inflammatory reaction as feature.General take weak, lassitude, loss of appetite, feel sick, detest greasy, hepatomegaly and abnormal liver function is main clinical manifestation, there is jaundice and heating in some patients were.If it is proper to cure nursing in time, the most of energy of the state of an illness are controlled and proceed to smoothly rehabilitation, but its main pathogenesis is complicated, is still not clear at present.In Chinese medicine, think that primary disease is many by emptiness of spleen and stomach, or careless because of diet, food and drink is unclean, so that transporting and transforming function of the spleen and stomach is not normal, and endogenous damp formation, or because of disorder of emotion, impairment caused by overstrain is excessive is felt again epidemic disease poison seasonal pathogen and fallen ill.The especially acute onset of falling ill be take excess syndrome as main, and pathogenesis is mainly evil poison, damp and hot temperte and refined, qi depression to blood stasis.
Cholecystitis is be subject to the invasion and attack of antibacterial, calculus, chemokines and be inflamed by biliary system, causes the gallbladder cystic disease of the various pathological changes of whole body and part.Modern medicine think block infection, blood fortune obstacle, functional disorder is the basic pathology process of cholecystitis, blocking is the key factor of morbidity.Chinese medicine thinks that primary disease is many because feelings will is disgruntled, impairing the liver causes suffocating of liver and gall mistake department, or because experiencing damp and hot heresy, and surfeit delicious food and give birth to damp and hotly affects catharsis and causes a disease.The pathogenesis of acute cholecystitis is retention of damp-heat in the interior, and liver and gall are lost and dredged, stagnation of QI-blood, the bright stagnation of QI and blood may bring about pain of accumulation of heat sun.The sick position of chronic cholecystitis relates to taste at gallbladder, and its pathogenesis is stagnation of QI due to depression of the liver, and gallbladder loses catharsis, retention of damp-heat in the interior, weakness of the spleen and stomach.
In sum, medical angle observation analysis therefrom, although liver, gallbladder disease belong to different, be again each other connect each other closely-related.The mechanism of their morbidities has the common feature of evil malicious invasion, retention of damp-heat in the interior and stagnation of QI-blood.The at present treatment of hepatitis, cholecystitis be take local application as main, generally adopts anti-inflammation or adds the calmness class medicine symptomatic treatment that relieves the pain, and these medicines can only be alleviated or treat focus, cannot thoroughly cure or eradicate.At present less for treat the Chinese patent medicine kind of hepatitis, cholecystitis simultaneously, cannot satisfy the demands.
[summary of the invention]
One of object of the present invention is to provide a kind of pharmaceutical composition for the treatment of hepatitis, cholecystitis, utilize the common pathogenesis of hepatitis and cholecystitis, treat hepatitis and cholecystitis simultaneously, the Chinese patent medicine kind of simultaneously treating hepatitis, cholecystitis in solution prior art is few, adopt anti-inflammation or add the calmness class medicine that relieves the pain and can only alleviate focus, the technical problem that cannot thoroughly cure or eradicate.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition.
Object of the present invention can realize by following technical measures:
A kind of pharmaceutical composition for the treatment of hepatitis, cholecystitis, wherein, the Chinese crude drug or its extract that comprise following weight portion: 100～150 parts of 100～200 parts of Herba Taraxacis, 15～30 parts, Radix Glycyrrhizae, 70～150 parts of Semen Coiciss, 30～80 parts, Pericarpium Citri Reticulatae Viride, 30～80 parts of Radix Bupleuri, 100～150 parts of Herba Artemisiae Annuaes and Fel Sus domestica.
Preferably, described pharmaceutical composition comprises Chinese crude drug or its extract of following weight portion: 100 parts of 150 parts of Herba Taraxacis, 25 parts, Radix Glycyrrhizae, 100 parts of Semen Coiciss, 50 parts, Pericarpium Citri Reticulatae Viride, 50 parts of Radix Bupleuri, 125 parts of Herba Artemisiae Annuaes and Fel Sus domestica.
Preferably, described extract is alcohol extract, water extract or volatile oil.
Preferably, described pharmaceutical composition also comprises pharmaceutically acceptable adjuvant, and described pharmaceutical composition is prepared to tablet, capsule, granule, pill, powder, suspensoid, powder, solution, drop or drop pill together with described adjuvant.
The present invention provides a kind of preparation method for the treatment of the pharmaceutical composition of hepatitis, cholecystitis in addition, wherein, raw material comprises: Herba Taraxaci 100～200 weight portions, Radix Glycyrrhizae 15～30 weight portions, Semen Coicis 70～150 weight portions, Pericarpium Citri Reticulatae Viride 30～80 weight portions, Radix Bupleuri 30～80 weight portions, Herba Artemisiae Annuae 100～150 weight portions and Fel Sus domestica 100～150 weight portions;
Described preparation method comprises the steps:
A, the Herba Artemisiae Annuae of the Herba Taraxaci of whole consumptions, Radix Glycyrrhizae and Semen Coicis and half consumption is ground into fine powder, decocts with water twice, decocting time is 2 hours for the first time, and decocting time is 1 hour for the second time, collecting decoction;
B, decocting liquid is precipitated, after precipitating, gained supernatant concentration is to thick paste shape;
C, Semen Coicis that will the Pericarpium Citri Reticulatae Viride of whole consumptions and Radix Bupleuri and half consumption are ground into fine powder after drying;
D, by the thick pasty masses of step b gained, step c gained fine powder, all the Fel Sus domestica of consumptions mixes, and adds appropriate simple syrup granulation.
Preferably, in described step b, the density of the thick pasty masses of gained is 1.25g/ml.
Preferably, the amount of water in described step a is respectively 10 times and 8 times of step a gained fine powder.
Preferably, after described steps d, also comprise the steps: steps d gained granule to be pressed into tablet.
Preferably, before described steps d, also comprise the steps: Fel Sus domestica to concentrate.
Compared with prior art, beneficial effect of the present invention is, pharmaceutical composition of the present invention makes full use of the common pathogenesis of hepatitis and cholecystitis, treats hepatitis and cholecystitis simultaneously; Pharmaceutical composition of the present invention with adopt anti-inflammation or add the calmness class medicine that relieves the pain and compare, therapeutic effect is good.
[specific embodiment]
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with specific embodiment, the present invention is described in further detail.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
The present invention is directed to hepatitis, cholecystitis, propose a kind of pharmaceutical composition, comprise that the Chinese crude drug of following weight portion or its extract form: 100～150 parts of 100～200 parts of Herba Taraxacis, 15～30 parts, Radix Glycyrrhizae, 70～150 parts of Semen Coiciss, 30～80 parts, Pericarpium Citri Reticulatae Viride, 30～80 parts of Radix Bupleuri, 100～150 parts of Herba Artemisiae Annuaes and Fel Sus domestica.
Pharmaceutical composition of the present invention, has the common feature of evil malicious invasion, retention of damp-heat in the interior and stagnation of QI-blood for the mechanism of hepatitis and cholecystitis morbidity.
In a preferred version of the present invention, described pharmaceutical composition comprises Chinese crude drug or its extract of following weight portion: 100 parts of 150 parts of Herba Taraxacis, 25 parts, Radix Glycyrrhizae, 100 parts of Semen Coiciss, 50 parts, Pericarpium Citri Reticulatae Viride, 50 parts of Radix Bupleuri, 125 parts of Herba Artemisiae Annuaes and Fel Sus domestica.
The extract of above-mentioned Chinese crude drug is alcohol extract, water extract or volatile oil; Aforementioned pharmaceutical compositions also can comprise pharmaceutically acceptable adjuvant, and described pharmaceutical composition is prepared to tablet, capsule, granule, pill, powder, suspensoid, powder, solution, drop or drop pill together with described adjuvant.Form and the dosage form of extract are well known to the skilled person.
In pharmaceutical composition of the present invention, each drug introduction is as follows:
Herba Taraxaci: Herba Taraxaci claim again to wet the bed grass, Pu Gongcao, Western Pu, for feverfew Herba Taraxaci Toraxacum mongolicumHand.Mazz., alkali Herba Taraxaci Toraxacum borealisinenseKitam. or belong to the dry herbs of several plants together; Have protect the liver, the effect of function of gallbladder promoting.
Radix Glycyrrhizae: be the root and rhizome of dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensisFisch., Glycyrrhiza inflata Bat. G.inflataBat. or Glycyrrhiza glabra L. G.glabraL.; There is antiinflammatory, antiviral, and protecting liver and detoxication and strengthen the effects such as immunologic function.
Semen Coicis: be the kernel of grass Semen Coicis Coix lacryma-jobi L.var.meyuan (Romen.) Stapf; There is spleen invigorating eliminating dampness by diuresis, the effect of eliminating impediment antidiarrheal.
Pericarpium Citri Reticulatae Viride: be the dry young fruit of rutaceae orange Citrus reticulata Blanco and variety thereof or the peel of immature fruit; There is soothing the liver dispelling the stagnated QI, the stagnant effect of removing food stagnancyization.
Radix Bupleuri: be the dry root of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum chinense scorzoner-ifolium Willd; There is expelling pathogenic factors from the exterior and expel the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, the effect of elevate a turnable ladder yang-energy.
Herba Artemisiae Annuae: be the dry aerial parts of feverfew Herba Artemisiae Annuae Artemisia annua L.; There is clearing away summer-heat, except steaming, the effect of preventing the attack (or recurrence) of malaria.
Fel Sus domestica: there is resolving heat and reducing pathogenic fire, liver heat removing stomach function regulating effect.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, wherein, raw material comprises: Herba Taraxaci 100～200 weight portions, Radix Glycyrrhizae 15～30 weight portions, Semen Coicis 70～150 weight portions, Pericarpium Citri Reticulatae Viride 30～80 weight portions, Radix Bupleuri 30～80 weight portions, Herba Artemisiae Annuae 100～150 weight portions and Fel Sus domestica 100～150 weight portions;
This preparation method comprises the steps:
Step 1, the Herba Artemisiae Annuae of the Herba Taraxaci of whole consumptions, Radix Glycyrrhizae and Semen Coicis and half consumption is ground into fine powder, decocts with water twice, decocting time is 2 hours for the first time, and decocting time is 1 hour for the second time, collecting decoction;
Step 2, decocting liquid is precipitated, after precipitating, gained supernatant concentration is to thick paste shape;
Step 3, Semen Coicis that will the Pericarpium Citri Reticulatae Viride of whole consumptions and Radix Bupleuri and half consumption are ground into fine powder after drying;
Step 4, by the thick pasty masses of step 2 gained, step 3 gained fine powder, all the Fel Sus domestica of consumptions mixes, and adds appropriate simple syrup granulation.
While decocting with water in step 1, twice amount of water is respectively 10 times and 8 times of step 1 gained fine powder amount.
In a preferred version of the present embodiment, in described step 2, the relative density of the thick pasty masses of gained is 1.25.
Further, before described step 4, also comprise the steps: Fel Sus domestica to concentrate.
embodiment 1
The present embodiment provides a kind of pharmaceutical composition for the treatment of hepatitis, cholecystitis to comprise: Herba Taraxaci 150g, Radix Glycyrrhizae 25g, Semen Coicis 100g, Pericarpium Citri Reticulatae Viride 50g, Radix Bupleuri 50g, Herba Artemisiae Annuae 125g and Fel Sus domestica 100g;
According to the method for being prepared as follows, be prepared:
Step S101: the Herba Artemisiae Annuae of the Herba Taraxaci of whole consumptions, Radix Glycyrrhizae and Semen Coicis and half consumption is ground into fine powder, decocts with water twice, decocting time is 2 hours for the first time, decocting time is 1 hour for the second time, collecting decoction, wherein, amount of water is respectively 10 times and 8 times of fine powder amount;
Step S102: decocting liquid is precipitated, and after precipitating, gained supernatant concentration is to thick paste shape;
Step S103: be ground into fine powder after the Semen Coicis of the Pericarpium Citri Reticulatae Viride of whole consumptions and Radix Bupleuri and half consumption is dried;
Step S104: the thick pasty masses of step S102 gained, step S103 gained fine powder, Fel Sus domestica are mixed, add appropriate simple syrup granulation;
Step S105: step S104 gained granule is pressed into 1000, tablet.
embodiment 2～embodiment 14
In the treatment hepatitis that embodiment 2～embodiment 17 provides, the pharmaceutical composition of cholecystitis, the concrete content of each component is as shown in table 1, and the preparation method of embodiment 2～embodiment 18 is identical with embodiment 1.
Table 1 is depicted as the concrete content of each component in the pharmaceutical composition for the treatment of hepatitis, cholecystitis
Application examples 1
Adopt the medicine composite for curing hepatitis of embodiment of the present invention 1-6
case selection
From the court, select 35 routine hepatitis, 60 years old mean age, average course of disease 36 months, adopts embodiment of the present invention 1-6(according to the situation of the state of an illness, the consumption of Chinese medicine to be adjusted) pharmaceutical composition.
diagnostic criteria
The diagnostic criteria of the hepatitis described in application examples 1 of the present invention: dizzy headache, nervous heart beating, severe patient costa sternales distension, limbs are become thin, myasthenia of limbs, skin is dark yellow.
therapeutic Method
By the proportioning of embodiment 1-6 and method, make tablet, 3 times on the one, general each 6; Within 30 days, be a course for the treatment of, observe altogether 2-3 the course for the treatment of.
During treatment, the pungent stimulation foods such as fasting wine, seafood.
treatment standard and result
Effective: after drug treatment, various transference cures, physical recovery is normal, observes 3 months without recidivist;
Take a turn for the better: various symptoms alleviate, and body constitution progressively takes a turn for the better;
Invalid: not reach improvement standard person.
therapeutic outcome
Effective 26 examples, 4 examples that take a turn for the better, invalid 5 examples;
Obvious effective rate 74.3%, improvement rate 11.4%, total effective rate is 85.7%.
Application examples 2
Adopt the medicine composite for curing cholecystitis of embodiment of the present invention 7-12
case selection
From the court, select 30 routine cholecystitis, 50 years old mean age, average course of disease 24 months, is divided into experimental group and matched group.
Experimental group: 20 examples adopt embodiment of the present invention 7-12(according to the situation of the state of an illness, the consumption of Chinese medicine to be adjusted) pharmaceutical composition.
Matched group: 10 examples adopt XIAOYAN LIDAN PIAN medicine for oral administration to treat.
diagnostic criteria
The diagnostic criteria of the cholecystitis described in application examples 2 of the present invention is: nausea and vomiting, and poor appetite, the lighter is uncomfortable in chest, severe patient breast muscle pain, mouth is told yellow liquid, obstinate.
therapeutic Method
Experimental group: by the proportioning of embodiment 7-12 and method, make tablet, 3 times on the one, general each 6; Within 30 days, be a course for the treatment of, observe altogether 2-3 the course for the treatment of.
Matched group: take XIAOYAN LIDAN PIAN, usage: every day 3 times, each 6.
During two groups of treatments, the pungent stimulation foods such as fasting wine, seafood.
treatment standard and result
Effective: after drug treatment, various transference cures, physical recovery is normal, observes 3 months without recidivist;
Take a turn for the better: various symptoms alleviate, pain disappears, and body constitution progressively takes a turn for the better;
Invalid: not reach improvement standard person.
therapeutic outcome
Experimental group: effective 15 examples, 3 examples that take a turn for the better, invalid 2 examples;
Obvious effective rate 75%, improvement rate 15%, total effective rate is 90%.
Matched group: effective 2 examples, 2 examples that take a turn for the better, invalid 6 examples;
Obvious effective rate 20%, improvement rate 20%, total effective rate is 40%.
The total effective rate of experimental group and obvious effective rate are obviously better than matched group (P<0.01).
Application examples 3
Adopt the pharmaceutical composition of embodiment of the present invention 7-12 to treat hepatitis and cholecystitis simultaneously
case selection
From the court, select 30 examples to suffer from the patient of hepatitis and cholecystitis, 55 years old mean age, average course of disease 24 months, adopts embodiment of the present invention 13-18(according to the situation of the state of an illness, the consumption of Chinese medicine to be adjusted simultaneously) pharmaceutical composition.
diagnostic criteria
The diagnostic criteria of the hepatitis described in application examples 3 of the present invention is: dizzy headache, nervous heart beating, and severe patient costa sternales distension, limbs are become thin, myasthenia of limbs, skin is dark yellow;
The diagnostic criteria of cholecystitis is: nausea and vomiting, and poor appetite, the lighter is uncomfortable in chest, severe patient breast muscle pain, mouth is told yellow liquid, obstinate.
therapeutic Method
By the proportioning of embodiment 13-18 and method, make tablet, 3 times on the one, general each 6; Within 30 days, be a course for the treatment of, observe altogether 2-3 the course for the treatment of.
During treatment, the pungent stimulation foods such as fasting wine, seafood.
treatment standard and result
Effective: after drug treatment, various transference cures, physical recovery is normal, observes 3 months without recidivist;
Take a turn for the better: various symptoms alleviate, pain disappears, and body constitution progressively takes a turn for the better;
Invalid: not reach improvement standard person.
therapeutic outcome
Hepatitis: effective 23 examples, 3 examples that take a turn for the better, invalid 4 examples;
Obvious effective rate 76.7%, improvement rate 10%, total effective rate is 86.7%.
Cholecystitis: effective 20 examples, 6 examples that take a turn for the better, invalid 4 examples;
Obvious effective rate 66.7%, improvement rate 20%, total effective rate is 96.7%.
The above the specific embodiment of the present invention, does not form limiting the scope of the present invention.Various other corresponding changes and distortion that any technical conceive according to the present invention is made, all should be included in the protection domain of the claims in the present invention.
Claims (9)
1. a pharmaceutical composition for the treatment of hepatitis, cholecystitis, it is characterized in that, comprise Chinese crude drug or its extract of following weight portion: 100～150 parts of 100～200 parts of Herba Taraxacis, 15～30 parts, Radix Glycyrrhizae, 70～150 parts of Semen Coiciss, 30～80 parts, Pericarpium Citri Reticulatae Viride, 30～80 parts of Radix Bupleuri, 100～150 parts of Herba Artemisiae Annuaes and Fel Sus domestica.
2. pharmaceutical composition according to claim 1, is characterized in that, comprises Chinese crude drug or its extract of following weight portion: 100 parts of 150 parts of Herba Taraxacis, 25 parts, Radix Glycyrrhizae, 100 parts of Semen Coiciss, 50 parts, Pericarpium Citri Reticulatae Viride, 50 parts of Radix Bupleuri, 125 parts of Herba Artemisiae Annuaes and Fel Sus domestica.
3. pharmaceutical composition according to claim 1, is characterized in that, described extract is alcohol extract, water extract or volatile oil.
4. pharmaceutical composition according to claim 1, it is characterized in that, described pharmaceutical composition also comprises pharmaceutically acceptable adjuvant, and described pharmaceutical composition is prepared to tablet, capsule, granule, pill, powder, suspensoid, powder, solution, drop or drop pill together with described adjuvant.
5. a preparation method for the treatment of the pharmaceutical composition of hepatitis, cholecystitis, it is characterized in that, raw material comprises: Herba Taraxaci 100～200 weight portions, Radix Glycyrrhizae 15～30 weight portions, Semen Coicis 70～150 weight portions, Pericarpium Citri Reticulatae Viride 30～80 weight portions, Radix Bupleuri 30～80 weight portions, Herba Artemisiae Annuae 100～150 weight portions and Fel Sus domestica 100～150 weight portions;
Described preparation method comprises the steps:
A, the Herba Artemisiae Annuae of the Herba Taraxaci of whole consumptions, Radix Glycyrrhizae and Semen Coicis and half consumption is ground into fine powder, decocts with water twice, decocting time is 2 hours for the first time, and decocting time is 1 hour for the second time, collecting decoction;
B, decocting liquid is precipitated, after precipitating, gained supernatant concentration is to thick paste shape;
C, Semen Coicis that will the Pericarpium Citri Reticulatae Viride of whole consumptions and Radix Bupleuri and half consumption are ground into fine powder after drying;
D, by the thick pasty masses of step b gained, step c gained fine powder, all the Fel Sus domestica of consumptions mixes, and adds appropriate simple syrup granulation.
6. preparation method according to claim 5, is characterized in that, in described step b, the relative density of the thick pasty masses of gained is 1.25.
7. preparation method according to claim 5, is characterized in that, the amount of water in described step a is respectively 10 times and 8 times of step a gained fine powder.
8. preparation method according to claim 5, is characterized in that, after described steps d, also comprises the steps: steps d gained granule to be pressed into tablet.
9. preparation method according to claim 5, is characterized in that, before described steps d, also comprises the steps: Fel Sus domestica to concentrate.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906445A (en) * | 2015-06-10 | 2015-09-16 | 孔令刚 | Traditional Chinese medicine for treating chronic cholecystitis |
| CN105920456A (en) * | 2016-05-31 | 2016-09-07 | 安徽皖斛堂生物科技有限公司 | Dendrobium officinale granules dedicated to hepatitis |
Citations (1)
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| CN101590213A (en) * | 2009-05-27 | 2009-12-02 | 吕文华 | Iithiasic Chinese medicine decoction of a kind of treatment and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101590213A (en) * | 2009-05-27 | 2009-12-02 | 吕文华 | Iithiasic Chinese medicine decoction of a kind of treatment and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 张沛峰: "慢性胆囊炎伴胆囊结石内科治疗分析", 《医学信息(中旬刊)》, no. 07 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906445A (en) * | 2015-06-10 | 2015-09-16 | 孔令刚 | Traditional Chinese medicine for treating chronic cholecystitis |
| CN105920456A (en) * | 2016-05-31 | 2016-09-07 | 安徽皖斛堂生物科技有限公司 | Dendrobium officinale granules dedicated to hepatitis |
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