CN103585281A - Zhenqi chewable tablets and preparation method thereof - Google Patents
Zhenqi chewable tablets and preparation method thereof Download PDFInfo
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Abstract
The invention discloses Zhenqi chewable tablets and a preparation method thereof. The Zhenqi chewable tablets are prepared from the following materials in parts by weight: 300 to 310 parts of radix astragali, 150 to 155 parts of fructus ligustri lucidi, and auxiliary materials including 85 to 135 parts of mannitol, 5 to 20 parts of dextrin, 5 to 20 parts of microcrystalline cellulose, 1.8 to 2.2 parts of aspartame, 0.3 to 0.4 parts of milk flavor, 0.2 to 0.3 parts of lemon essence, 1 to 2 parts of magnesium stearate, and 1 to 10 parts of povidone K30. The Zhenqi chewable tablets provided by the invention can solve the problems of simplex dosage form and inconvenience in taking of the existing Zhenqi preparation, and is suitable for the aged, children, and patients suffering from stroke, dysphagia and gastrointestinal dysfunction, and can well bring the pharmaceutical effects into play.
Description
Technical field
The present invention relates to a kind of loyal stilbene chewable tablet and preparation method thereof, belong to Chinese drug preparation technique field.
Background technology
ZHENQI FUZHENG KELI has following drug effect: improve body's immunity; Hemocytes increasing, protection bone marrow, adrenal cortex and liver function; Promote interferon to produce; Coordinate tumor patient Radiotherapy chemotherapy, alleviate the toxic and side effects during patient's Radiotherapy chemotherapy, improve patient's late result and life quality.Current loyal stilbene preparation is mostly granule, need to take after a large amount of water-solubleization, so pharmaceutical effectiveness may be affected, and drug effect is not satisfactory, and dosage form is single, is difficult for promoting.
And chewable tablet is by chewing in oral cavity or sucking the tablet that clothes are swallowed after sheet is dissolved, often add sucrose, Herba Menthae wet goods sweeting agent and flavorant to adjust taste, through chewing, rear surface is long-pending to increase tablet, can promote medicine dissolving and absorption in vivo, carry, taking convenience, can swallow, chew containing sucking or with taking after aqueous dispersion.Even if also can guarantee to take medicine on time under exsiccosis, be especially applicable to old man, child, paralytic, the difficulty of swallowing and the poor patient of gastrointestinal function, can reduce medicine gastrointestinal is born, can better bring into play its drug effect.In addition, chewable tablet, owing to having increased correctives, can be designed to the taste that child likes, and allows child without the fear of taking medicine, and has strengthened the fairness of taking medicine.
The present invention changes agent by loyal stilbene granule exactly, makes chewable tablet, makes it be more suitable for old man, child, paralytic, the difficulty of swallowing and the poor patient of gastrointestinal function and takes.
Summary of the invention
The object of the invention is to, a kind of loyal stilbene chewable tablet and preparation method thereof is provided, can solve existing loyal stilbene preparation formulation single, take inconvenient problem, be more suitable for old man, child, paralytic, the difficulty of swallowing and the poor patient of gastrointestinal function and take, can better bring into play drug effect.
For solving the problems of the technologies described above, the present invention adopts following technical scheme:
A kind of loyal stilbene chewable tablet, the raw material by following parts by weight: 300～310 parts of the Radixs Astragali, 150～155 parts of Fructus Ligustri Lucidi, and adjuvant: 1～10 part, 85～135 parts, mannitol, 5～20 parts, dextrin, 5～20 parts of microcrystalline Cellulose, 1.8～2.2 parts of Aspartane, 0.3～0.4 part of milk flavour, 0.2～0.3 part of Fructus Citri Limoniae essence, 1～2 part of magnesium stearate, PVP K30 are made.
Can select the raw material of following preferred weight umber: 300 parts of the Radixs Astragali, 150 parts of Fructus Ligustri Lucidi, and adjuvant: 5 parts, 110 parts, mannitol, 11 parts, dextrin, 11 parts of microcrystalline Cellulose, 2 parts of Aspartane, 0.35 part of milk flavour, 0.25 part of Fructus Citri Limoniae essence, 1.5 parts of magnesium stearate, PVP K30 are made.
The preparation method of aforementioned loyal stilbene chewable tablet comprises the following steps:
S1, takes the Radix Astragali, Fructus Ligustri Lucidi by formula proportion, extracting in water 3 times, and merge extractive liquid,, then carry out ultrafiltration, filtrate is concentrated into the clear paste of relative density 1.30～1.45;
S2, gets above-mentioned clear paste, take PVP K30 as binding agent, then adds mannitol, dextrin, microcrystalline Cellulose, adopts wet granulation or one-step palletizing, dry, granulate;
S3, then add magnesium stearate, Aspartane, Fructus Citri Limoniae essence and milk flavour, mix homogeneously, tabletting, obtains label;
S4, film coating, obtains.
In the step S1 of the preparation method of aforesaid loyal stilbene chewable tablet, by formula proportion, take the Radix Astragali, Fructus Ligustri Lucidi powder, cross 40 mesh sieves, take water as extracting medium, and boiling is extracted three times, each 30～120 minutes, solid-liquid ratio is respectively 1:10,1:8,1:8, merges the extracting solution of three times.
The art for coating of the preparation method of aforesaid loyal stilbene chewable tablet is specially: label is placed in to seed-coating machine, start hot air apparatus and air exhausting device, label is preheating to 40 ℃, take the coating powder of label weight 4%, be made into 8% aqueous solution, the coating of whitewashing, coating solution flow is 10g/min, coating pan rotating speed is 6～8 turn/min, obtains.
For guaranteeing the drug effect of preparation of the present invention, applicant has carried out a series of experimental study and screening to the kind of adjuvant and consumption, and its drug effect has been carried out to contrast experiment's research.
One, adjuvant screening
The effect of each adjuvant refers to table 1.
Table 1
Because preparation of the present invention adopts full extractum chewable tablet, therefore, when adjuvant screens, mainly filler, disintegrating agent, correctives, lubricant, binding agent have been carried out preferably.
1, the screening of filler
The filler of chewable tablet generally adopts dextrin, sucrose, starch, mannitol, microcrystalline Cellulose etc.Filler can improve disintegration time, hygroscopicity, hardness and the compressibility of tablet, now with identical addition, filler is screened, and the results are shown in Table 2.
Table 2
| Filler | Hygroscopicity | Hardness | Disintegration time |
| Dextrin | Slower | Very hard | 43 minutes |
| Sucrose | Comparatively fast | Softer | 37 minutes |
| Mannitol | Slower | Softer | 34 minutes |
| Dextrin+starch+sucrose | Comparatively fast | Moderate | 41 minutes |
| Dextrin+mannitol+microcrystalline Cellulose | Slower | Moderate | 38 minutes |
As can be seen from the above table, using dextrin+mannitol+microcrystalline Cellulose the most suitable as filler.
Consumption to filler screens, and experimental result is in Table 3.
Table 3
Note: pharmacopeia stipulates that all regulations check the tablet of dissolution, release, no longer carry out inspection disintegration; The tablet that regulation is carried out inspection disintegration has: conventional tablet, Film coated tablets, coated tablet, buccal tablet, Sublingual tablet, fuse, effervescent tablet.Although chewable tablet is not need to carry out inspection disintegration, chewable tablet of the present invention has coating, therefore need to carry out the inspection of disintegration.
Mannitol is white crystalline powder, and cooling taste is sweet, soluble in water, and no hygroscopicity be best filler and the correctives of chewable tablet, but addition conference causes tablet hardness inadequate; Add dextrin can increase tablet hardness, add microcrystalline Cellulose can reduce disintegration time.As seen from the above table, when filler coordinates with the weight ratio mannitol of 10: 1: 1, dextrin, microcrystalline Cellulose, effect is best.
2, correctives screening
The good taste of chewable tablet is very important, also easily by patient, is accepted.Although selected a large amount of mannitol in filler, the granule sweet taste of making is inadequate, also needs to add appropriate correctives again, regulates mouthfeel.Once selected sucrose, Aspartane, Aspartane+milk flavour+Fructus Citri Limoniae essence as correctives, experiment repeatedly, tastes through many people, and experimental result is in Table 4.
Table 4
Note: good+; Better ++; Fine +++.
As seen from the above table, add Aspartane, Fructus Citri Limoniae essence and milk flavour as correctives, mouthfeel is best, forms " citrus scented and the milk fragrance " of special taste, is people, and the taste that particularly child very easily accepts and likes, has strengthened the fairness of taking medicine.
3, lubricant screening
Before tabletting, must add and can increase mobility of particle, reduce die wear, be easy to slice, there is the lubricant of lubrication.Common lubricant has magnesium stearate, Pulvis Talci and micropowder silica gel, with same amount, adds in granule, measures its angle of repose, investigates its impact on tabletting process, the results are shown in Table 5.
Table 5
| Lubricant | Pulvis Talci | Magnesium stearate | Micropowder silica gel |
| Angle of repose | 36.2° | 37.6° | 35.7° |
As seen from the above table, single from fluidizer effect, Pulvis Talci and micropowder silica gel are slightly better than magnesium stearate, but magnesium stearate is except lubrication, also can improve the outward appearance of slice, thin piece, the glossiness and the cost that increase plain sheet are lower than the above two, consider lower selection magnesium stearate more suitable.
Further investigate the consumption of magnesium stearate, the results are shown in Table 6.
Table 6
As seen from the above table, along with the increase of magnesium stearate consumption, angle of repose is on a declining curve, but when magnesium stearate consumption is too much, can causes sliver or affect disintegration of tablet degree; When magnesium stearate consumption is very few, can cause sticking, cause sheet heavy inhomogeneous.Therefore, can draw: the consumption of magnesium stearate within the scope of 1.0～2.0g all can, and add 1.5g magnesium stearate best.
Two, pharmacodynamic experiment research
1, experiment material
1.1 Experimental agents: commercially available ZHENQI FUZHENG JIAONANG; The loyal stilbene chewable tablet of preparing according to the present invention.
1.2 laboratory animals: Kunming mouse, ♀ ♂ half and half, body weight 20 ± 0.7g, is provided by Guiyang Medical College Experimental Animal Center; Laboratory illumination is sufficient, and ventilation is good, room temperature 18～22, ℃ humidity 50%～70%, routinely regularly sterilization; Freely drink water, diet, mice rearging cage sub-cage rearing, observes and adapts to 5 days before zoopery, checks after qualified and starts to enter formal experiment.
2, experimental technique
Take immune organ weight, Peritoneal Macrophage Phagocytosis is index, has compared loyal stilbene chewable tablet prepared by commercially available ZHENQI FUZHENG JIAONANG and the present invention impact on mouse immune activity.
2.1 impacts on mouse immune organ
Get 36 of Kunming mouses, be divided at random three groups, normal saline matched group, ZHENQI FUZHENG JIAONANG group, loyal stilbene chewable tablet group.Same dose, successive administration 7 days, gets mouse thymus and spleen is weighed, and the mg/g body weight of take is calculated Thymus and Spleen index as index, the results are shown in Table 7.
Table 7 ZHENQI FUZHENG JIAONANG and loyal stilbene chewable tablet are on the impact of mouse immune organ (X ± S, n=12)
With the comparison of normal saline matched group:
*p<0.05,
*p<0.01.
As seen from the above table, loyal stilbene chewable tablet can obviously increase the thymus index of normal mouse, and ZHENQI FUZHENG JIAONANG is without this effect; ZHENQI FUZHENG JIAONANG and loyal stilbene chewable tablet all can significantly increase mouse spleen weight.
2.2 impacts on Peritoneal Macrophage Phagocytosis
Administration is the same, last administration next day, puts to death mice, cuts off rapidly mouse peritoneal skin, aseptic injection Hank ' s solution 3mL, the centrifugal 10min of 1000r/min.Use phosphate buffer standardize solution, add 0.5% chicken red blood cell 0.2Ml.In 37, ℃ 5%CO
2incubator, hatches 30min.The liquid dyeing of centrifugal push jack ，Yong Switzerland, microscopy, calculates phagocytic percentage and phagocytic index, the results are shown in Table 8.
Table 8 ZHENQI FUZHENG JIAONANG and loyal stilbene chewable tablet are on the impact of Phagocytosis By The Peritoneal Macrophages In Mice (X ± S, n=12)
With the comparison of normal saline matched group:
*p<0.05,
*p<0.01.
As seen from the above table, ZHENQI FUZHENG JIAONANG and loyal stilbene chewable tablet all can increase the quantity of Turnover of Mouse Peritoneal Macrophages, but the short phagocytosis of loyal stilbene chewable tablet is more remarkable compared with ZHENQI FUZHENG JIAONANG.
In sum, compare with existing Zhenqi Fuzheng prepn, loyal stilbene chewable tablet prepared by the present invention has shown better effect aspect pharmacodynamics.
In addition, in order to improve drug appearance, strengthen visual sense of beauty, applicant is also studied film coating procedure and optimizes, and is specifically addressed below.Wherein, equipment and material refer to table 9.
Table 9
| Equipment/title material | Manufacturer |
| ZP-35A rotary tablet machine | Shanghai Tian He pharmaceutical machine factory |
| BG-150B high-efficiency coating machine | Harbin nano pharmacy complete set of equipments company limited |
| WW-1.6/1.7 oil-free air compressor | Anshan oilless (oil free) compressor company limited |
| 78X-2 matrix agent four-function analyzer | Shanghai Huanghai Sea medicine inspection instrument plant |
| FA1604S electronic balance | Ten thousand/, Shanghai balance equipment factory |
| Loyal stilbene chewable tablet label | Self-control |
| Efficient film coating powder | Shanghai Colorcon Coating Technology Co., Ltd |
1, the preparation of coating solution
Suitable quantity of water is injected with starting in the agitator tank of agitator, started agitator, make whole liquid level stir into whirlpool and drive the liquid in container, speed is difficult for too fast, in case be involved in too much air.At the uniform velocity to add in whirlpool, can not make powder swim on liquid level coating powder, reinforced process should complete in 5 minutes.After reinforced, adjust mixing speed, continue to stir 40 minutes, can complete the preparation of coating solution.
2, for optimizing the optimum process condition of coating, concentration, coating solution flow and the coating pan rotating speed of selected coating solution are three investigation factors, take coated tablet appearance yield as investigating index.Investigation the results are shown in Table 10.
Table 10
As seen from the above table, it is the highest adopting the art for coating condition of second group to prepare film-coated appearance yield, therefore, preferred film coating procedure is: label is placed in to seed-coating machine, starts hot air apparatus and air exhausting device, label is preheating to 40, the coating powder that ℃ takes label weight 4%, is made into 8% aqueous solution, the coating of whitewashing, coating solution flow is 10g/min, and coating pan rotating speed is 6～8 turn/min.
Adopt above-mentioned preferred art for coating to carry out film coating, qualification rate is up to 99.8%, color even, and clothing layer is firmly smooth, complete, thin and weightening finish is little, aesthetic in appearance, and patient is easy to accept.
Compared with prior art, the present invention is directed to existing loyal stilbene preparation formulation single, take inconvenience etc. deficiency, it is changed to agent, the loyal stilbene chewable tablet of making is swallowed after chewing in oral cavity, can reduce the burden of medicine to intestinal, is particularly suitable for old man, child, paralytic, the difficulty of swallowing and the poor patient of gastrointestinal function and takes, because tablet is chewed, rear surface is long-pending to increase simultaneously, can promote dissolving and the absorption of medicine, experimental studies have found that, its better efficacy.
In addition, the chewable tablet made from this formula, the degree of chewing is moderate, without firmly special, can be broken in mouth, the process of chewing is clear and melodious, and shattering process, with slight sound, has better mouthfeel.The essence that this formula adds has slight volatilization, and uncork has delicate fragrance, has the effect that promotes appetite, improves mood, and the Fructus Citri Limoniae essence adding for 7-18 year child and teenager especially, is more suitable for child's taste.
The specific embodiment
The embodiment of the present invention 1: a kind of loyal stilbene chewable tablet is to be made by Radix Astragali 300g, Fructus Ligustri Lucidi 150g, mannitol 110g, dextrin 11g, microcrystalline Cellulose 11g, Aspartane 2g, milk flavour 0.35g, Fructus Citri Limoniae essence 0.25g, magnesium stearate 1.5g, PVP K30 5g.Concrete preparation method is: take Fructus Ligustri Lucidi, astragalus membranaceus powder, cross 40 mesh sieves, take water as extracting medium, boiling is extracted three times, and each 80 minutes, solid-liquid ratio was respectively 1:10,1:8,1:8, merged the extracting solution of three times; Carry out ultrafiltration, filtrate is concentrated into the clear paste of relative density 1.35 again; In clear paste, add PVP K30, stir evenly, as binding agent, then add mannitol, dextrin, microcrystalline Cellulose, wet granulation, dry, granulate; Add again magnesium stearate, Aspartane, Fructus Citri Limoniae essence and milk flavour, mix homogeneously, tabletting, obtains label; Label is placed in to seed-coating machine, starts hot air apparatus and air exhausting device, label is preheating to 40, ℃ take the coating powder of label weight 4%, be made into 8% aqueous solution, the coating of whitewashing, coating solution flow is 10g/min, coating pan rotating speed is 7 turn/min, obtains.
The embodiment of the present invention 2: a kind of loyal stilbene chewable tablet is to be made by Radix Astragali 310g, Fructus Ligustri Lucidi 155g, mannitol 135g, dextrin 20g, microcrystalline Cellulose 20g, Aspartane 2.2g, milk flavour 0.4g, Fructus Citri Limoniae essence 0.3g, magnesium stearate 2g, PVP K30 10g.Concrete preparation method is: take Fructus Ligustri Lucidi, astragalus membranaceus powder, cross 40 mesh sieves, take water as extracting medium, boiling is extracted three times, and each 30 minutes, solid-liquid ratio was respectively 1:10,1:8,1:8, merged the extracting solution of three times; Carry out ultrafiltration, filtrate is concentrated into the clear paste of relative density 1.45 again; In clear paste, add PVP K30, stir evenly, as binding agent, then add mannitol, dextrin, microcrystalline Cellulose, one-step palletizing, dry, granulate; Add again magnesium stearate, Aspartane, Fructus Citri Limoniae essence and milk flavour, mix homogeneously, tabletting, obtains label; Label is placed in to seed-coating machine, starts hot air apparatus and air exhausting device, label is preheating to 40, ℃ take the coating powder of label weight 4%, be made into 8% aqueous solution, the coating of whitewashing, coating solution flow is 10g/min, coating pan rotating speed is 6 turn/min, obtains.
The embodiment of the present invention 3: a kind of loyal stilbene chewable tablet is to be made by Radix Astragali 305g, Fructus Ligustri Lucidi 152.5g, mannitol 85g, dextrin 5g, microcrystalline Cellulose 5g, Aspartane 1.8g, milk flavour 0.3g, Fructus Citri Limoniae essence 0.2g, magnesium stearate 1g, PVP K30 1g.Concrete preparation method is: take Fructus Ligustri Lucidi, astragalus membranaceus powder, cross 40 mesh sieves, take water as extracting medium, boiling is extracted three times, and each 120 minutes, solid-liquid ratio was respectively 1:10,1:8,1:8, merged the extracting solution of three times; Carry out ultrafiltration, filtrate is concentrated into the clear paste of relative density 1.30 again; In clear paste, add PVP K30, stir evenly, as binding agent, then add mannitol, dextrin, microcrystalline Cellulose, wet granulation, dry, granulate; Add again magnesium stearate, Aspartane, Fructus Citri Limoniae essence and milk flavour, mix homogeneously, tabletting, obtains label; Label is placed in to seed-coating machine, starts hot air apparatus and air exhausting device, label is preheating to 40, ℃ take the coating powder of label weight 4%, be made into 8% aqueous solution, the coating of whitewashing, coating solution flow is 10g/min, coating pan rotating speed is 8 turn/min, obtains.
Claims (5)
1. a loyal stilbene chewable tablet, it is characterized in that, the raw material by following parts by weight: 300～310 parts of the Radixs Astragali, 150～155 parts of Fructus Ligustri Lucidi, and adjuvant: 1～10 part, 85～135 parts, mannitol, 5～20 parts, dextrin, 5～20 parts of microcrystalline Cellulose, 1.8～2.2 parts of Aspartane, 0.3～0.4 part of milk flavour, 0.2～0.3 part of Fructus Citri Limoniae essence, 1～2 part of magnesium stearate, PVP K30 are made.
2. loyal stilbene chewable tablet according to claim 1, it is characterized in that, the raw material by following parts by weight: 300 parts of the Radixs Astragali, 150 parts of Fructus Ligustri Lucidi, and adjuvant: 5 parts, 110 parts, mannitol, 11 parts, dextrin, 11 parts of microcrystalline Cellulose, 2 parts of Aspartane, 0.35 part of milk flavour, 0.25 part of Fructus Citri Limoniae essence, 1.5 parts of magnesium stearate, PVP K30 are made.
3. the preparation method of loyal stilbene chewable tablet as claimed in claim 1, is characterized in that, comprises the following steps:
S1, takes the Radix Astragali, Fructus Ligustri Lucidi by formula proportion, extracting in water 3 times, and merge extractive liquid,, then carry out ultrafiltration, filtrate is concentrated into the clear paste of relative density 1.30～1.45;
S2, gets above-mentioned clear paste, take PVP K30 as binding agent, then adds mannitol, dextrin, microcrystalline Cellulose, adopts wet granulation or one-step palletizing, dry, granulate;
S3, then add magnesium stearate, Aspartane, Fructus Citri Limoniae essence and milk flavour, mix homogeneously, tabletting, obtains label;
S4, film coating, obtains.
4. the preparation method of loyal stilbene chewable tablet according to claim 3, it is characterized in that: in step S1, by formula proportion, take the Radix Astragali, Fructus Ligustri Lucidi powder, cross 40 mesh sieves, take water as extracting medium, and boiling is extracted three times, each 30～120 minutes, solid-liquid ratio is respectively 1:10,1:8,1:8, merges the extracting solution of three times.
5. the preparation method of loyal stilbene chewable tablet according to claim 3, it is characterized in that, art for coating is specially: label is placed in to seed-coating machine, starts hot air apparatus and air exhausting device, label is preheating to 40 ℃, take the coating powder of label weight 4%, be made into 8% aqueous solution, the coating of whitewashing, coating solution flow is 10g/min, coating pan rotating speed is 6～8 turn/min, obtains.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878400A (en) * | 2015-01-22 | 2016-08-24 | 北京海吉星医疗科技有限公司 | Glossy privet fruit and radix astragali body resistance strengthening composition for treating cardiac failure |
| CN106619831A (en) * | 2015-07-31 | 2017-05-10 | 北京海吉星医疗科技有限公司 | Fructus ligustri lucidi-milkvetch root body resistance strengthening instant freeze-drying tablet and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723986A (en) * | 2005-06-10 | 2006-01-25 | 湖南麓山天然植物制药有限公司 | Effervescent tablets contg. Astragalus root and fructus ligustric lucidi for strengthening the body resistance, and its prepn. art |
| CN1833661A (en) * | 2006-01-12 | 2006-09-20 | 石圣洪 | Spirulina chewing tablets and prepn. thereof |
-
2013
- 2013-11-21 CN CN201310597371.8A patent/CN103585281A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723986A (en) * | 2005-06-10 | 2006-01-25 | 湖南麓山天然植物制药有限公司 | Effervescent tablets contg. Astragalus root and fructus ligustric lucidi for strengthening the body resistance, and its prepn. art |
| CN1833661A (en) * | 2006-01-12 | 2006-09-20 | 石圣洪 | Spirulina chewing tablets and prepn. thereof |
Non-Patent Citations (1)
| Title |
|---|
| 刘笑茹等: "蓝莓枸杞咀嚼片的研制", 《食品工业科技》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878400A (en) * | 2015-01-22 | 2016-08-24 | 北京海吉星医疗科技有限公司 | Glossy privet fruit and radix astragali body resistance strengthening composition for treating cardiac failure |
| CN106619831A (en) * | 2015-07-31 | 2017-05-10 | 北京海吉星医疗科技有限公司 | Fructus ligustri lucidi-milkvetch root body resistance strengthening instant freeze-drying tablet and preparation method thereof |
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Application publication date: 20140219 |