CN103550410B - Drug composition for losing weight, preparation containing same and preparation method of drug composition - Google Patents
Drug composition for losing weight, preparation containing same and preparation method of drug composition Download PDFInfo
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Abstract
The invention relates to a medicine composition for losing weight, a preparation containing the same and a preparation method of the medicine composition. The medicine composition comprises the following medicines: 2-25 parts of roses, 2-25 parts of peach tree roots, 2-25 parts of camellia, 2-25 parts of white radish and 5-50 parts of pearl powder and is prepared through the processes of grinding, mixing and soaking. The medicine composition has the functions of burning fat and removing grease, promoting blood circulation to remove meridians, cooling to diminish inflammation and whitening and tendering skins and has total significant weight losing efficiency of 96.5%, and the cured patients maintain normal dietary habits without rebound phenomenon after finishing treatment, thus the medicine composition is a safe pure weight losing traditional Chinese medicine for external use, which takes effect quickly, has short course of treatment and avoids easy relapse of diseases.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to a kind of pharmaceutical composition of fat-reducing, containing its preparation and preparation method.
Background technology
Obesity (adiposity) is one group of common, ancient metabolism disease group.When human body feed heat is more than consumption of calorie, waste heat is with storage as fat in body, and its amount exceedes normal physiological requirement, and then develops into obesity when reaching certain value.Because the increase of body fat makes be above standard body weight 20% or Body Mass Index [BMI=body weight (k)/height (m) 2] of body weight be greater than 24 and be called obesity.As can be the person of seeking claimed simple obesity without the obvious cause of disease; There is clear and definite cause of disease person and be called secondary obesity.
It is attractive in appearance that obesity not only affects human body, the more important thing is and affect health, as obesity can cause hypertension (overweight people's sickness rate is 25 ~ 55%), diabetes (overweight people's sickness rate is 14 ~ 20%), coronary heart disease (overweight people's sickness rate is 10 ~ 15%), hyperlipemia (overweight people's sickness rate is 35 ~ 53%), sleep apnea (overweight people's sickness rate is 10 ~ 20%), depression (in overweight people, sickness rate is 70 ~ 90%) etc., other also comprises tumor, infertility, calculus etc. and life-span and the direct unforgettable relevant disease of a few inferior quality of living.Acute disease is when particularly obesity reaches morbid obesity (BMI is more than 40), and its mortality rate can sharply increase.Fat and relevant disease is more and more registered attention, along with science and technology impact is progressive, is fatly subject to not diagnosis and treatment to have large development.
The medicine for the treatment of of obesity conventional at present mainly contains two classes: a kind of is the appetite suppressant acting on maincenter: this type of medicine is also known as anorexic medicine, it is the activity by the mediator that affects the nerves, reduce five hydroxytryptamine and norepinephrine reuptake, thus minimizing food intake dose, appetite-suppressing and raising basal metabolic rate carry out loss of weight, as sibutramine.Also having a kind of is the lipase inhibitor acting on periphery: reach fat-reducing object by the absorption blocking partial fat in diet, as orlistat, suppresses gastric lipase and pancreas at GI tract, thus reduces the absorption about 30% of fat.The patient B MI of Drug therapy is needed to be greater than 30kg/m
2and without complication, or be greater than 28kg/m
2have other complication, but this type of drug side effect is obvious, and easily rebounds.Take surgical operation therapy to reach the object of fat-reducing in addition in addition, but surgery cost is high and there is certain operation risk.
Therefore, provide one safely and effectively appetrol become urgent problem.
Inventor, in order to overcome the above problems, have developed a kind of new compositions.
Employing Western medicine of the prior art or operative treatment are to reach the object of fat-reducing, but Western medicine side effect is large, and easily rebound; There is certain risk in operative treatment, costly.
2, the medicine of fat-reducing provided by the invention has the fat that disappears and deoils, promoting blood circulation to remove obstruction in the collateral, refrigerant antiinflammatory, effect of whitening and softening skin, its total obvious effective rate 96.5% of losing weight, and healing person is after end treatment, keeps normal dietary habit, without rebound phenomena, the pure Chinese medicine external slimming medicine be a kind of safety, instant effect, curative effect are short, not easily recurring.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for slimming.
Another object of the present invention is to the preparation that a kind of slimming medicine is provided.
Another object of the present invention is to the preparation method that a kind of pharmaceutical composition for slimming is provided.
The present invention also provides the application of the preparation of pharmaceutical composition in preparation treatment body fat disease, described obesity is that face is fat, hand is fat, abdominal obesity, waist are fat, leg fat in one or more positions fat.
The invention provides a kind of pharmaceutical composition of fat-reducing, comprise the medicine of following weight portion: Flos Rosae Rugosae 2-25 part, Radix Persicae 2-25 part, Flos Camelliae Japonicae 2-25 part, white turnip 2-25 part, Margarita powder 5-50 part.
Aforesaid pharmaceutical composition, also comprises Oleum Camelliae 10-60 part, olive oil 10-70 part, Mel 2-25 part.
Aforesaid pharmaceutical composition, also comprises salt 5-50 part, white vinegar 2-25 part.
Aforesaid pharmaceutical composition, is grouped into by the one-tenth of following weight portion: Flos Rosae Rugosae 4-20 part, Radix Persicae 4-20 part, Flos Camelliae Japonicae 4-20 part, white turnip 4-20 part, Margarita powder 8-40 part, Oleum Camelliae 12-50 part, olive oil 20-60 part, Mel 4-20 part, salt 7-40 part, white vinegar 4-20 part.
Aforesaid pharmaceutical composition, is preferably grouped into by the one-tenth of following weight portion: Flos Rosae Rugosae 5 parts, Radix Persicae 5 parts, Flos Camelliae Japonicae 5 parts, white turnip 5 parts, Margarita powder 10 parts, Oleum Camelliae 15 parts, 45 parts, olive oil, Mel 5 parts, salt 10 parts, white vinegar 5 parts.
The preparation of described pharmaceutical composition, said preparation is made by described compositions through common process or is made up through common process of compositions and pharmaceutically acceptable adjuvant.
The preparation of aforesaid pharmaceutical composition, said preparation is liniment.
The application in preparation treatment body fat disease of the preparation of described pharmaceutical composition, described obesity is that face is fat, hand is fat, one or more positions obesity in abdominal obesity, waist obesity, leg, buttocks obesity.
The preparation method of described pharmaceutical composition, comprises the following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 1-3cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is cut into the segment that 1-3cm is long, immerses in salt and take out after 1-10 days, dry, smash to pieces, for subsequent use;
5) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses 1-5 days in Mel, for subsequent use;
6) by Margarita powder and step 3), 4), 5) standby mix, for subsequent use;
7) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
8) standby in step 6) is added in the miscella in step 7) and soak 15-30 days, stir evenly, to obtain final product.
The preparation method of described pharmaceutical composition, preferably includes following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 2cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is cut into the segment that 2cm is long, immerses in salt and take out after 3 days, dry, smash to pieces, for subsequent use;
5) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 3 days, for subsequent use;
6) by Margarita powder and step 3), 4), 5) standby mix, for subsequent use;
7) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
8) standby in step 6) is added in the miscella in step 7) and soak 20 days, stir evenly, to obtain final product.
Described adjuvant is selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives, wherein:
Described filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose.
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, micropowder silica gel, Pulvis Talci or magnesium stearate.
Described surfactant is selected from the smooth or Polysorbate (tween) of dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fatty acid Pyrusussuriensis.
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
Described diluent is selected from water, edible oil.
Slimming medicine provided by the invention has the following advantages:
1, compared with prior art:
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: liniment
Composition: Flos Rosae Rugosae 5g, Radix Persicae 5g, Flos Camelliae Japonicae 5g, white turnip 5g, Margarita powder 10g, Oleum Camelliae 15g, olive oil 45g, Mel 5g, salt 10g, white vinegar 5g.
Preparation method:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 2cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is cut into the segment that 2cm is long, immerses in salt and take out after 3 days, dry, smash to pieces, for subsequent use;
5) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 3 days, for subsequent use;
6) by Margarita powder and step 3), 4), 5) standby mix, for subsequent use;
7) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
8) standby in step 6) is added in the miscella in step 7) and soak 20 days, stir evenly, to obtain final product.
Embodiment 2: liniment
Composition: Flos Rosae Rugosae 4g, Radix Persicae 4g, Flos Camelliae Japonicae 4g, white turnip 4g, Margarita powder 8g part, Oleum Camelliae 12g, olive oil 20g, Mel 4g, salt 7g, white vinegar 4g.
Preparation method
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 1cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is cut into the segment that 1cm is long, immerses in salt and take out after 1 day, dry, smash to pieces, for subsequent use;
5) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 1 day, for subsequent use;
6) by Margarita powder and step 3), 4), 5) standby mix, for subsequent use;
7) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
8) standby in step 6) is added in the miscella in step 7) and soak 15 days, stir evenly, to obtain final product.
Embodiment 3: liniment
Composition: Flos Rosae Rugosae 20g, Radix Persicae 20g, Flos Camelliae Japonicae 20g, white turnip 20g, Margarita powder 40g, Oleum Camelliae 50g, olive oil 60g, Mel 20g, salt 40g, white vinegar 20g.
Preparation method:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 3cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is cut into the segment that 3cm is long, immerses in salt and take out after 10 days, dry, smash to pieces, for subsequent use;
5) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 5 days, for subsequent use;
6) by Margarita powder and step 3), 4), 5) standby mix, for subsequent use;
7) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
8) standby in step 6) is added in the miscella in step 7) and soak 30 days, stir evenly, to obtain final product.
Embodiment 4: liniment
Composition: Flos Rosae Rugosae 10g, Radix Persicae 10g, Flos Camelliae Japonicae 10g, white turnip 10g, Margarita powder 15g, Oleum Camelliae 20g, olive oil 30g, Mel 10g, salt 15g, white vinegar 10g.
Preparation method:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 2cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is cut into the segment that 2cm is long, immerses in salt and take out after 5 days, dry, smash to pieces, for subsequent use;
5) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 3 days, for subsequent use;
6) by Margarita powder and step 3), 4), 5) standby mix, for subsequent use;
7) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
8) standby in step 6) is added in the miscella in step 7) and soak 25 days, stir evenly, to obtain final product.
Embodiment 5 liniment
Composition: Flos Rosae Rugosae 2g, Radix Persicae 2g, Flos Camelliae Japonicae 2g, white turnip 2g, Margarita powder 5g.
Preparation method: the composition taking weight portion, is ground into fine powder, the water adding 0.5 times amount is mixed thoroughly, to obtain final product.
Embodiment 6 liniment
Composition: Flos Rosae Rugosae 25g, Radix Persicae 25g, Flos Camelliae Japonicae 25g, white turnip 25g, Margarita powder 50g.
Preparation method: prepare by the method for embodiment 5 and get final product.
Embodiment 7 liniment
Composition: Flos Rosae Rugosae 2g, Radix Persicae 2g, Flos Camelliae Japonicae 2g, white turnip 2g, Margarita powder 5g, Oleum Camelliae 10g, olive oil 10g, Mel 2g.
Preparation method: prepare by the method for embodiment 5 and get final product.
Embodiment 8 liniment
Composition: Flos Rosae Rugosae 25g, Radix Persicae 25g, Flos Camelliae Japonicae 25g, white turnip 25g, Margarita powder 50g, Oleum Camelliae 60g, olive oil 70g, Mel 25g.
Preparation method: prepare by the method for embodiment 5 and get final product.
Embodiment 9 liniment
Composition: Flos Rosae Rugosae 5g, Radix Persicae 5g, Flos Camelliae Japonicae 5g, white turnip 5g, Margarita powder 10g, Oleum Camelliae 15g, olive oil 45g, Mel 5g, salt 10g, white vinegar 5g.
Preparation method: prepare by the method for embodiment 5 and get final product.
Embodiment 10 liniment
Composition: Flos Rosae Rugosae 2g, Radix Persicae 2g, Flos Camelliae Japonicae 2g, white turnip 2g, Margarita powder 5g, Oleum Camelliae 10g, olive oil 10g, Mel 2g, salt 5g, white vinegar 2g.
Preparation method: prepare by the method for embodiment 5 and get final product.
Embodiment 11 liniment
Composition: Flos Rosae Rugosae 25g, Radix Persicae 25g, Flos Camelliae Japonicae 25g, white turnip 25g, Margarita powder 50g, Oleum Camelliae 60g, olive oil 70g, Mel 25g, salt 50g, white vinegar 25g.
Preparation method: prepare by the method for embodiment 5 and get final product.
Experimental example 1
With the product of the embodiment of the present invention 5, clinical trial MethodsThe cases enrolled 30 example, more than 85 kilograms 8 people, 65-85 kilogram of 13 people, 55-65 kilogram of 9 people, are ABW and are above standard the fat personage of body weight more than 10%.
Usage: patient first cleans local with warm water, dries, is put on affected part with described ointment.Once a day, within seven days, be a course for the treatment of, generally use 4 courses for the treatment of.
Standard body weight (kg)=[height (cm)-100] X0.90
At treatments period, once a day, and measure height, body weight by special messenger, keep constant measuring condition (as urinate, defecation time, feed and amount of drinking water, wear the clothes, move, the factor such as perspiration) to reduce error.
Following (the body weight unit: kg of clinical test results statistics of the present invention; Unit of time: sky):
Show 1:7 days internal therapy statistical effects
| Original body weight | ≥85 | 65-85 | 55-65 |
| Body weight after treatment | 75-80 | 60-80 | 51-61 |
| Reduce body weight | 5-10 | 3-7.5 | 2.5-5.8 |
Table 2: all treatment terminates rear curative effect statistics
| Original body weight | ≥85 | 65-85 | 55-65 |
| Body weight after treatment | 60-72 | 55-65 | 47-57 |
| Reduce body weight | 20.5-31 | 14.6-22 | 5-9.7 |
| Treatment time | 28 | 28 | 28 |
Experimental example 2
Clinical report: by the product of the embodiment of the present invention 1 treatment 205 example, age 16-65 year, 45 years old mean age.
Course of disease 1-20,70 examples relevant to diet of falling ill, 80 examples relevant with heredity, 18 examples relevant with puerperal, with postoperative 5 relevant examples, reduce 26 relevant examples with activity, agnogenic 6 examples; Wherein severe simple obesity, body weight has 50 examples more than 100 kilograms.
Usage: patient first cleans local with warm water, dries, is put on affected part with described ointment.Once a day, within seven days, be a course for the treatment of, generally use 4 courses for the treatment of.
In 205 examples that result is treated through the present invention 15 days effective:
40 examples that conscious disease alleviates, lose weight 9 kilograms;
Effective subjective symptoms is obviously alleviated, lose weight 13 kilograms 80 example;
Specific, body weight declined 16 kilograms within 15 days 78 examples;
Invalid: conscious disease is without significant change, and lose weight 2 kilogram of 7 example.
The present invention with body weight declined in 15 days be no more than 2 kilograms for invalid, total effective rate reaches 96.5%.
Do not observe the side effect such as allergy, edema
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. a pharmaceutical composition for fat-reducing, is characterized in that, be made up of the composition of following weight portion: Flos Rosae Rugosae 2-25 part, Radix Persicae 2-25 part, Flos Camelliae Japonicae 2-25 part, white turnip 2-25 part, Margarita powder 5-50 part.
2. a pharmaceutical composition for fat-reducing, is characterized in that, be made up of the composition of following weight portion: Flos Rosae Rugosae 2-25 part, Radix Persicae 2-25 part, Flos Camelliae Japonicae 2-25 part, white turnip 2-25 part, Margarita powder 5-50 part, Oleum Camelliae 10-60 part, olive oil 10-70 part, Mel 2-25 part.
3. a pharmaceutical composition for fat-reducing, is characterized in that, be made up of the composition of following weight portion: Flos Rosae Rugosae 2-25 part, Radix Persicae 2-25 part, Flos Camelliae Japonicae 2-25 part, white turnip 2-25 part, Margarita powder 5-50 part, Oleum Camelliae 10-60 part, olive oil 10-70 part, Mel 2-25 part, salt 7-40 part, white vinegar 4-20 part
4. pharmaceutical composition according to claim 3, it is characterized in that, be made up of the composition of following weight portion: Flos Rosae Rugosae 4-20 part, Radix Persicae 4-20 part, Flos Camelliae Japonicae 4-20 part, white turnip 4-20 part, Margarita powder 8-40 part, Oleum Camelliae 12-50 part, olive oil 20-60 part, Mel 4-20 part, salt 7-40 part, white vinegar 4-20 part.
5. pharmaceutical composition according to claim 4, is characterized in that, is made up of the composition of following weight portion: Flos Rosae Rugosae 5 parts, Radix Persicae 5 parts, Flos Camelliae Japonicae 5 parts, white turnip 5 parts, Margarita powder 10 parts, Oleum Camelliae 15 parts, 45 parts, olive oil, Mel 5 parts, salt 10 parts, white vinegar 5 parts.
6., containing the preparation of pharmaceutical composition described in any one of claim 1-5, it is characterized in that, said preparation is made up through common process of described compositions and pharmaceutically acceptable adjuvant.
7. the preparation of pharmaceutical composition according to claim 6, is characterized in that, said preparation is liniment.
8. the application of the preparation of pharmaceutical composition according to claim 6 in the medicine of preparation treatment body fat disease, described obesity is that face is fat, hand is fat, one or more positions obesity in abdominal obesity, waist obesity, leg, buttocks obesity.
9. the preparation method of pharmaceutical composition as described in any one of claim 3-5, is characterized in that comprising the following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 1-3cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is cut into the segment that 1-3cm is long, immerses in salt and take out after 1-10 days, dry, smash to pieces, for subsequent use;
5) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses 1-5 days in Mel, for subsequent use;
6) by Margarita powder and step 3), 4), 5) standby mix, for subsequent use;
7) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
8) by step 6) in standby add step 7) in miscella in soak 15-30 days, stir evenly, to obtain final product.
10. a preparation method for pharmaceutical composition as claimed in claim 9, is characterized in that comprising the following steps:
1) each medicine is taken by formula;
2) clean, drain;
3) fritter white turnip being cut into 2cm long adds the fiery fried dry of white vinegar, smashs to pieces, for subsequent use;
4) Radix Persicae is cut into the segment that 2cm is long, immerses in salt and take out after 3 days, dry, smash to pieces, for subsequent use;
5) by Flos Rosae Rugosae, Flos Camelliae Japonicae powder is broken into fine powder and immerses in Mel 3 days, for subsequent use;
6) by Margarita powder and step 3), 4), 5) standby mix, for subsequent use;
7) by Oleum Camelliae and mixed with olive oil, miscella is obtained, for subsequent use;
8) by step 6) in standby add step 7) in miscella in soak 20 days, stir evenly, to obtain final product.
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| CN201310532803.7A CN103550410B (en) | 2013-10-31 | 2013-10-31 | Drug composition for losing weight, preparation containing same and preparation method of drug composition |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102076A (en) * | 1993-10-30 | 1995-05-03 | 夏金法 | Fresh bamboo shoots, fruit, vegetable juice (powder) series natural drink and its preparation method |
| CN1709140A (en) * | 2005-07-08 | 2005-12-21 | 周云川 | Composite melissa powder and its production process |
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2013
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102076A (en) * | 1993-10-30 | 1995-05-03 | 夏金法 | Fresh bamboo shoots, fruit, vegetable juice (powder) series natural drink and its preparation method |
| CN1709140A (en) * | 2005-07-08 | 2005-12-21 | 周云川 | Composite melissa powder and its production process |
Non-Patent Citations (1)
| Title |
|---|
| 药用花卉――玫瑰花;卢颖等;《新闻世界(健康生活)》;20070505(第05期);31 * |
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Effective date of registration: 20171206 Address after: 558000 Dushan hi tech Industrial Park, Dushan County, Qiannan Buyi and Miao Autonomous Prefecture, Guizhou Patentee after: Guizhou Miao Yuan Industrial Co., Ltd. Address before: 504 558000 mailbox 1-2 layer, Gan Tang Town, Tuyun City, Guizhou Province Patentee before: DUYUN CITY YEKAXIANG BIOTECHNOLOGY FACTORY |
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Address after: 558000 Dushan high tech Industrial Park, Qiannan Buyei and Miao Autonomous Prefecture, Guizhou Province, China Patentee after: Guizhou Heyou Industry Co., Ltd Address before: 558000 Dushan hi tech Industrial Park, Dushan County, Qiannan Buyi and Miao Autonomous Prefecture, Guizhou Patentee before: Guizhou Miao Yuan Industrial Co., Ltd. |