CN103518768B - Suspension agent composition containing Imidacloprid and Buprofezin - Google Patents

Abstract

The invention belongs to the field of pesticides, and relates to a suspension composition containing imidacloprid and buprofezin, which is characterized in that the mass-number ratio of imidacloprid and buprofezin is 1-2:20, and the suspension also contains 1-10% Dispersant, 0.1-10% thickener, 0.2-8% antifreeze, 0.2-8% defoamer, 0.2-8% preservative and 0.1-5% and pH regulator, in which the dispersant is carboxylate The dispersant, the composition can prevent and control a variety of Homoptera, Coleoptera and Thysanoptera pests in cotton, vegetables and fruit trees, and it can be diluted 500-1500 times for spraying.

Description

Suspension concentrate composition containing imidacloprid and buprofezin

technical field

The invention belongs to the field of pesticides, and relates to a suspension composition containing imidacloprid and buprofezin. The suspension composition has good effects on Homoptera and Thysanoptera pests.

Background technique

Rice planthoppers, aphids, whiteflies, scale insects, thrips and other pests are important pests on rice, vegetables, fruit trees, cotton and other crops. These pests have a large reproduction rate and obvious generation overlap. Due to the single and unscientific use of pesticides, these pests have developed resistance to varying degrees, and chemical pesticides are still used as the main control species in agricultural and forestry production, causing environmental pollution and ecological environment damage. In recent years, due to the prohibition of methidon, the market lacks better pesticides for controlling scale insects. The research and development of new pesticides has become a hot spot for the sustainable development of agriculture and forestry. Combining two components with different structures and different mechanisms of action is an effective way to reduce and delay resistant pests and improve drug efficacy.

Buprofezin is a type of high-efficiency and low-toxicity insecticide, which is not easy to produce resistance to pests, and is safe for the environment, humans, livestock, natural enemies of pests and other beneficial foods. At present, wettable powders have been developed in China. Imidacloprid not only has high efficiency, broad-spectrum and good root systemic, contact and stomach poisoning effects, but also is safe for the environment. one. The inventor has carried out a large number of compounding and auxiliary agent screening tests of buprofezin and imidacloprid, and found unexpected effects. Moreover, the suspending agent with water as solvent can reduce the capacity of organic solvent and has no dust pollution, so it has become an important formulation in the development of pesticides. The inventors found unexpected results in the preparation research of Buprofezin and Imidacloprid.

Contents of the invention

The object of the present invention is to provide a suspension concentrate composition containing imidacloprid and buprofezin with synergistic and stable quality.

A suspension composition containing imidacloprid and buprofezin of the present invention is characterized in that the mass and number ratio of imidacloprid and buprofezin is 1-2:20, and the mass of imidacloprid and buprofezin accounts for 10% of the total content of the suspension. -80%, the suspending agent also contains 1-10% dispersant.

In the suspension composition of the present invention, the mass fraction ratio of imidacloprid and buprofezin is 1-6:12, and the dispersant is one or more of GY-D-04, DSC-2001 and D-1003.

The above suspension of the present invention is characterized in that it also contains 0.1-10% thickener, 0.2-8% antifreeze, 0.2-8% defoamer, 0.2-8% preservative and 0.1-5% pH regulator, The thickener is selected from one or more of xanthan gum, gum arabic, gelatin, magnesium aluminum silicate, methyl cellulose, and the defoamer is selected from silicone oil, organic silicone, pentadecanoic acid, n-octanol , one or more of polymerized glycerin, fatty acid, polyoxypropylene glyceryl ether, the preservative is one of sodium sorbate, sodium benzoate, and butylparaben, and the pH regulator is ammonia water, acetic acid or citric acid one or several.

The invention provides a suspending agent composition which can prevent and control pests of Homoptera, Coleoptera, Thysanoptera and other crops such as cotton, vegetables and fruit trees. Further preferably, it is used for preventing and controlling fruit tree scale insects.

The composition of the present invention is used in the method for preventing and controlling various pests of crops such as cotton, vegetables, fruit trees, etc., and is characterized in that it is diluted 500-1500 times and sprayed.

Compared with the prior art, the suspending agent composition of the present invention produces the following beneficial effects:

(1) The composition has a synergistic effect;

(2) Suspending agent of the present invention uses carboxylate compound as dispersant, and the quality of suspending agent is more stable;

(3) The suspending agent of the present invention uses carboxylate compound as the dispersant, and the insecticidal effect of the suspending agent is better.

specific embodiment

The present invention will be further described below in conjunction with embodiment, but the present invention is by no means limited to following embodiment.

Embodiment 1 is to the selection of mango scale insect optimum ratio

1. Test insects

The test insect was Unaspisyanonensis, which was collected from mango trees in Changjiang County, Hainan Province. After the samples were taken back, the 1st instar nymphs were picked to remove dirt, egg shells and other worms, and the worms with the same body color and uniform size were selected from the 1st instar nymphs for use.

2. Drugs and reagents

Test drug A: Imidacloprid (Jiangsu Changqing Agrochemical Co., Ltd.), content 95%, provided by Hainan Zhengye Zhongnong Hi-Tech Co., Ltd., dissolved in dichloromethane;

Test drug B: Buprofezin (Buprofezin) original drug (Nantong Shizhuang Chemical Co., Ltd., Jiangsu Province), with a content of 98.5%, provided by Hainan Zhengye Zhongnong Hi-Tech Co., Ltd., dissolved in acetone.

3. Test method

Preparation of mother liquor: Dissolve the original drug of imidacloprid in dichloromethane, and dissolve the original drug of buprofezin in acetone. The dissolved mother liquors of the two original medicines are mixed according to the set ratio. The mixed mother liquor was diluted with deionized water into a series of concentrations.

Measuring method: Immerse the mango leaves with 1-year-old nymphs in the liquid medicine for 5 seconds, take them out and absorb the excess liquid with filter paper, and then put them into a constant temperature box at 26°C. Three leaves were treated with each concentration, and three leaves were treated with organic solvents (dichloromethane and acetone solution) in the same way as a control. At least 50 test insects were kept on each leaf, and each treatment was repeated 4 times. On the 4th day after putting it in the incubator, check the survival situation of the test insects on each leaf under a dissecting microscope, and record the number of dead and alive insects. If the color is fresh, yellow or light yellow, it is regarded as a live insect, and if the insect body is shriveled and the color is dull, it is regarded as a dead insect. The trial was not valid if the organic solvent treatment had a mortality rate higher than 20%.

Investigation statistics: investigate the number of dead insects after a certain period of time, and use Abbott formula to calculate the corrected mortality rate. Calculate the lethal intermediate concentration LC ₅₀ of each test agent by computer program, and calculate the co-toxicity coefficient (CTC value) of mixed agents according to Sun Yunpei's method, and the CTC value greater than 120 is considered synergistic effect. The specific calculation method is as follows:

A single dose (A) is set as a standard single dose, and its toxicity index (TI) is designated as 100, then:

Theoretical toxicity index (TTI) of the mixture = ΣTI of each single agent × the percentage of the single agent in the mixture

The test results are shown in Table 1.

Table 1 Evaluation of the combined effects of imidacloprid-buprofezin mixture on mango scale insects

The mass fraction ratios of buprofezin: imidacloprid were respectively 2:27, 2:25, 2:24, 2:21, 2:19, 2:17, 2:15, 2:13, 2:11 for testing, The results are shown in Table 1. It shows that the co-toxicity coefficients of the compound agents to mango scale insects are all greater than 1, indicating that the compound agents do not produce antagonism on the insecticidal activity of mango scale insects after mixing according to these mixing ratios. Among them, the three ratios with the best effect of Buprofezin·Imidacloprid mixture were 2:21, 2:19, and 2:17, which indicated that these mixing ratios had a synergistic effect.

Dispersant selection in embodiment 2 suspending agent

Mix 4 g of imidacloprid, 34 g of buprofezin, 1 g of xanthan gum, 2 g of ethylene glycol, 0.5 g of silicone oil, and 0.5 g of sodium sorbate, add 2 g of dispersant and mix well. Dispersants are sodium lignosulfonate, calcium lignosulfonate, GY-D-04, alkylphenol polyoxyethylene phosphate, sodium dodecylsulfonate, sodium methylene bis-naphthalenesulfonate, Pull open powder, Nongru No. 2000 series, DSC-2001 and D-1003, respectively process into 38% acetamidobuprofezin suspension concentrate, and the suspension concentrate number is preparation 1-preparation 10. The stability of the preparation was observed under storage at different temperatures, and according to the results, a more stable suspending agent was selected for the determination of the suspension rate (according to GB/T14825-2006). See Table 2 and Table 3 for results.

It was found from Table 2 that among the 10 38% imidacloprid·buprofezin suspension formulations with different dispersants, the formulations with better stability were formulation 3, formulation 6, formulation 9 and formulation 10. As can be seen from Table 3, the suspensibility measurement results of preparation 3, preparation 6, preparation 9 and preparation 10 are above 90%, reaching the quality standard of suspending agent.

It can be known from Table 2 and Table 3 that the suspensions with GY-D-04, DSC-2001 and D-1003 as dispersants are relatively stable and have a high suspension rate, and these 3 dispersants are all carboxylate dispersants.

The appearance stability of table 2 preparation

preparation Varieties of Dispersants in Suspension Concentrates Day 2 20°C 1 week at 20°C 2 weeks at 40°C 2 weeks at 54°C Preparation 1 Sodium lignosulfonate Stablize Stablize Layered 2mm, stable layered 3mm stable Preparation 2 calcium lignosulfonate Stablize Stablize Layered 2mm, stable layered 3mm stable Preparation 3 GY-D-04 Stablize Stablize Stablize Stablize Preparation 4 Alkylphenol Polyoxyethylene Phosphate Stablize Stablize layered 1.5mm stable layered 3mm stable Preparation 5 Sodium dodecyl sulfonate Stablize Stablize layered 1.5mm stable layered 2mm stable Preparation 6 Sodium methylene bis-naphthalene sulfonate Stablize Stablize Stablize layered 0.5mm stable Preparation 7 pull open powder Stablize Stablize layered 1mm stable layered 1mm stable Preparation 8 Farm milk 2000 series Stablize Stablize layered 1mm stable layered 1mm stable Preparation 9 DSC-2001 Stablize Stablize Stablize Stablize Preparation 10 D-1003 Stablize Stablize Stablize Stablize

Table 338% Imidacloprid Buprofezin Suspended Concentrate Suspension Ratio Determination Results of Heat Storage Stability Test

The quality index of embodiment 3 preparations

Taking the preparation 3 of Example 2 as an example, carry out the mensuration of other indicators of 38% imidacloprid buprofezin suspension concentrate, measure pH (carry out by the pH meter method in GB/T1601 " method for the determination of pH value of pesticides "), lasting Foaming (according to the method in GB/T28137-2011), pouring (after placing the suspending agent sample in the container for a certain period of time, pour it according to the prescribed procedure, and measure the amount of sample remaining in the container; After washing the container with water, measure the amount of sample in the container), wet sieving effect (determined by "wet sieving method" in GB/T16150-1995), low temperature stability (according to "suspension preparation" in GB/T19137-2003 specified method). As a result, it was found that the pH, pouring property, persistent foaming property, wet sieving and low-temperature stability indicators of formulation 3 all reached the standard of suspending agent.

In order to verify the batch production quality of Preparation 3, 5 batches of production samples were randomly selected for all-item testing, and the results are shown in Table 4.

Table 438% imidacloprid Buprofezin suspension concentrate measured data

It is known from Table 4 that all indicators of the product are qualified through random sampling inspection.

Embodiment 434% imidacloprid Buprofezin suspension concentrate

Mix 4g of imidacloprid, 30g of buprofezin, DSC-20016g, 1g of gum arabic, 3g of glycerin, 0.5g of organosilicone, and 1g of sodium sorbate, thoroughly mix them, add 30g of water and grind them thoroughly, make up to 100g of water, and prepare 34% imidacloprid Buprofezin suspension concentrate.

Embodiment 538% imidacloprid Buprofezin suspension concentrate

Fully mix imidacloprid 4g, buprofezin 34g, D-10035g, gelatin 0.5g, propylene glycol 3g, pentadecanoic acid 0.5g, sodium benzoate 1g, add water 25g to fully grind, water make up to 100g, and prepare 38% imidacloprid·thiazide Azinonone suspension.

Embodiment 638% imidacloprid Buprofezin suspension concentrate

Mix 4g of imidacloprid, 34g of buprofezin, 6g of DSC-2001, 1g of gum arabic, 3g of glycerin, 0.5g of organosilicone, and 1g of sodium sorbate, add 30g of water to fully grind, add water to 100g, and prepare 38 % imidacloprid Buprofezin suspension concentrate.

Embodiment 742% imidacloprid Buprofezin suspension concentrate

Mix 4g of imidacloprid, 38g of buprofezin, 3g of GY-D-04, 0.2g of magnesium aluminum silicate, 5g of ethylene glycol, 0.5g of n-octanol, and 0.5g of butylparaben, and add 25g of water to grind it thoroughly. Make up to 100g with water, and prepare 42% imidacloprid·buprofezin suspension concentrate.

Embodiment 8 suspension concentrate is to the field control effect of mango scale insect

Test drug: the preparation is prepared by the company's technical center;

Base survey: the control crop is mango scale insects, investigate the base number of mango scale insects before spraying, number and list;

Application method: spray method. Spray 20m ² (30Kg/667m ² ) in each plot, using a hand-held sprayer for spraying, requiring uniform spraying, and spraying clean water as a control.

Drug efficacy investigation and statistics: Investigate the survival of test insects at different times after drug application, and calculate the control effect with the following formula. There was no rainfall for 3 days after spraying. The results are shown in Table 5.

Table 5 Field control effects of several pesticides on mango scale insects

As can be seen from Table 5, after the preparation 3, preparation 6, preparation 9 and preparation 10 are diluted 1000 times, the control effect on mango scale insect 1 day after the drug is more than 80%, and it is higher than 25% buprofezin diluted 500 times and 45% imidacloprid diluted 1000 times; 3 days after the drug, the effects of preparation 3, preparation 9 and preparation 10 were all higher than the effect of a single dose of 25% buprofezin and 45% imidacloprid. In the case where the ingredients of formulation 3, formulation 6, formulation 9 and formulation 10 are only different in dispersant, the effects of formulation 3, formulation 9 and formulation 10 are all higher than those of formulation 6, which fully demonstrates that formulation 3, formulation 9 and formulation The effect of the carboxylate dispersant in 10 on the formulation is higher than that of other dispersants. In view of the control spectrum of the single agent buprofezin and imidacloprid, the compound agent can control various pests of Homoptera, Coleoptera, Thysanoptera and other crops such as cotton, vegetables and fruit trees.

Claims (4)

1. one kind contains the suspension agent composition of Imidacloprid and Buprofezin, it is characterized in that the ratio of quality and the number of copies of Imidacloprid and Buprofezin is 2:17, it is 38% that Imidacloprid and Buprofezin quality account for suspending agent gross mass, also containing 1-10% dispersant in suspending agent, dispersant is GY-D-04, one or more in DSC-2001 and D-1003, also containing 0.1-10% thickener, 0.2-8% antifreezing agent, 0.2-8% defoamer, 0.2-8% preservative and 0.1-5%pH conditioning agent, thickener is selected from xanthans, gum Arabic, gelatin, aluminium-magnesium silicate, one or more in methylcellulose, defoamer is selected from silicone oil, organic silicone, pentadecanoic acid, n-octyl alcohol, polyglycerol, fatty acid, one or more in polypropylene glycerol aether, preservative is sodium sorbate, Sodium Benzoate, one in butyl hydroxybenzoate, pH adjusting agent is ammoniacal liquor, one or more of acetic acid or citric acid.

2. suspension agent composition according to claim 1, is characterized in that, described suspension agent composition can prevent and treat cotton, vegetables, the Homoptera of fruit tree, coleoptera, Thysanoptera.

3. suspension agent composition according to claim 2, is characterized in that, described suspension agent composition can prevent and treat scale insect of fruit tree.

4. the application method of suspension agent composition according to claim 1, is characterized in that, described suspension agent composition, when the various pests of control cotton, vegetables, fruit tree crop, dilutes 500-1500 times of spray applications.