CN103499519A - Composite physical field transdermal drug delivery experiment device - Google Patents
Composite physical field transdermal drug delivery experiment device Download PDFInfo
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- CN103499519A CN103499519A CN201310467795.2A CN201310467795A CN103499519A CN 103499519 A CN103499519 A CN 103499519A CN 201310467795 A CN201310467795 A CN 201310467795A CN 103499519 A CN103499519 A CN 103499519A
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- chamber
- receiving chamber
- drug delivery
- transdermal drug
- physical field
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- 238000002474 experimental method Methods 0.000 title claims abstract description 26
- 238000013271 transdermal drug delivery Methods 0.000 title claims abstract description 13
- 239000002131 composite material Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 22
- 239000011229 interlayer Substances 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 239000012086 standard solution Substances 0.000 claims abstract description 11
- 239000002504 physiological saline solution Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 8
- 230000035515 penetration Effects 0.000 claims abstract description 8
- 230000005684 electric field Effects 0.000 claims abstract description 7
- 239000000243 solution Substances 0.000 claims abstract description 7
- 230000003204 osmotic effect Effects 0.000 claims abstract 3
- 239000011521 glass Substances 0.000 claims description 16
- 238000007789 sealing Methods 0.000 claims description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 230000001502 supplementing effect Effects 0.000 claims 1
- 230000035699 permeability Effects 0.000 description 15
- 239000003814 drug Substances 0.000 description 7
- 238000009792 diffusion process Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 238000001764 infiltration Methods 0.000 description 5
- 230000008595 infiltration Effects 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 238000010276 construction Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000011435 rock Substances 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 230000002687 intercalation Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
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- Electrotherapy Devices (AREA)
Abstract
一种复合物理场经皮给药实验装置，包括用于储放实验时配制的待渗透的标准溶液的供给室、用于存放标准生理盐水的接受室，供给室与接受室通过夹层隔开，夹层上开始有渗透孔，渗透孔上设置有使供给室内的标准溶液通过渗透方式进入接受室内的标准生理盐水中的实验皮肤，还设有用于给接受室补充标准生理盐水的补给室，补给室的下部与接受室连通，并且补给室内的液面高度高于接受室内的液面，供给室内设置有用于给标准溶液渗透过程施加电场的电极。本发明通过电极嵌入电极槽的设置实现了超声波和电场等作用因子同时作用于实验皮肤，而且还设置有补给室可以有效的给接受室补充溶液，使得取液后接受室中的溶液依然跟皮肤模型接触，不影响实验。
A compound physical field transdermal drug delivery experiment device, comprising a supply chamber for storing the standard solution to be infiltrated prepared during the experiment, and a receiving chamber for storing standard physiological saline, the supply chamber and the receiving chamber are separated by an interlayer, The interlayer begins to have osmotic holes, and the osmotic holes are provided with experimental skins that allow the standard solution in the supply chamber to enter the standard physiological saline in the receiving chamber through osmosis. The lower part of the chamber communicates with the receiving chamber, and the liquid level in the supply chamber is higher than that in the receiving chamber, and the supply chamber is provided with electrodes for applying an electric field to the standard solution penetration process. The present invention realizes that the action factors such as ultrasonic wave and electric field act on the experimental skin at the same time through the setting of the electrode embedded in the electrode groove, and is also provided with a supply chamber that can effectively replenish the solution to the receiving chamber, so that the solution in the receiving chamber is still in contact with the skin after taking the liquid. Model contact, does not affect the experiment.
Description
Technical field
The present invention relates to a kind of cutaneous penetration diffusion experiment device, especially relate to a kind of compound physical field percutaneous dosing experimental provision.
Background technology
Cutaneous penetration is a kind of non-invasive administration new way, and its drug absorption is not subject to the impact of the complicated factors such as alimentary canal and enteron aisle, and overcome that the drug oral bioavilability is low, injection pain and liver first-pass effect.The various physical enhancement methods such as iontophoresis, iontophoresis, electroporation can be improved the skin permeability, increase the transmitance of medicine.
While in the percutaneous dosing process, using certain short infiltration method separately, its facilitation to percutaneous drug absorption is not very desirable.Most research all is devoted to two or more short infiltration methods and is combined use, makes them to the infiltration of medicine, produce synergy.Various short oozing make the transdermal technology obtain significant progress aspect security, high efficiency, targeting combining of technology.At field of medicaments, transdermal drug delivery system will be familiar with and study by increasing researcher as not a kind of alternative delivery system.
Along with compound short further investigation of oozing, the simple experimental provisions such as Franz diffusion cell, Valia-Chien diffusion cell, two Room circulation diffusion cells, self-control diffusion cell can not meet compound short demand of oozing experiment far away.Be designed although more and more simulate in recent years the Franz disperser, can't meet equally the compound short requirement of experiment of oozing that multiple physical agent applies simultaneously.
Improve the limitation in existing diffusion experiment medicine pond, design and can apply the compound short experimental provision oozed of multiple physical agent simultaneously, be convenient to the compound short further investigation of oozing experiment of physical field, promote the compound short development of oozing of physical field.
Summary of the invention
The objective of the invention is the deficiency for solving the problems of the technologies described above, a kind of compound physical field percutaneous dosing experimental provision is provided, solved the problem that the acting factors such as ultrasound wave and electric field can't act on simultaneously.
The present invention is the deficiency solved the problems of the technologies described above, and the technical scheme adopted is:
A kind of compound physical field percutaneous dosing experimental provision, the supply chamber that comprises the standard solution to be infiltrated for storing when experiment preparation, for the receiving chamber of depositing standard physiological saline, supply chamber and receiving chamber separate by interlayer, start to have permeability hole on interlayer, be provided with the standard solution made in supply chamber on permeability hole and enter the experiment skin in the standard physiological saline in receiving chamber by penetration mode, also be provided with for supplement the replenishing chamber of standard physiological saline to receiving chamber, the bottom of replenishing chamber is communicated with receiving chamber, and the liquid level in replenishing chamber is higher than the liquid level in receiving chamber, in supply chamber, be provided with for apply the electrode of electric field to the standard solution process of osmosis.
Offer on the interlayer of described permeability hole both sides for laying the slot electrode of electrode, in supply chamber, on two opposing sidewalls, be symmetrical arranged the glass clamp base that is useful on fixed electorde.
The distance of described glass clamp base and interlayer is 12-18mm.
The distance of described glass clamp base and interlayer is 15mm.
The 0.8-1.2 that the degree of depth of described slot electrode is thickness of electrode doubly.
The degree of depth of described slot electrode is identical with the thickness of electrode.
Described skin model seals and is fixed on permeability hole by O-ring seal.
Offer on described receiving chamber sidewall for extracting the liquid outlet of the rear solution of infiltration, be provided with openable sealing-plug in liquid outlet.
In described receiving chamber, magnetic stir bar is installed.
Described magnetic stir bar is positioned at the below of permeability hole.
The invention has the beneficial effects as follows: the present invention acts on experiment skin by the acting factors such as having realized ultrasound wave and electric field that arranges of electrode intercalation electrode groove simultaneously, can be effectively to receiving chamber's make-up solution but also be provided with replenishing chamber, make and get the solution in receiving chamber after liquid and, still with the skin model contact, do not affect experiment.
The accompanying drawing explanation
The one-piece construction 45 degree oblique views that Fig. 1 is experimental provision of the present invention;
The one-piece construction vertical view that Fig. 2 is experimental provision of the present invention;
Fig. 3 is experimental provision one-piece construction side view of the present invention;
Fig. 4 is that experimental provision of the present invention is subject to chamber and communication chamber structural drawing;
The sandwich construction figure that Fig. 5 is experimental provision of the present invention;
Fig. 6 is fixedly schematic diagram of experimental provision skin of the present invention.
Graphical indicia: 1, supply chamber, 2, receiving chamber, 3, electrode cable, 4, electrode, 401, slot electrode, 5, permeability hole, 6, magnetic stir bar, 7, the glass clamp base, 8, adjustable glass folder bolt, 9, replenishing chamber, 10, interlayer, 11, glass clamp base boring, 12, liquid outlet, 13, skin model, 14, O-ring seal.
Embodiment
Shown in figure, embodiment is as follows:
A kind of compound physical field percutaneous dosing experimental provision, the supply chamber 1 that comprises the standard solution to be infiltrated for storing when experiment preparation, for the receiving chamber of depositing standard physiological saline, supply chamber 1 separates by interlayer 10 with receiving chamber 2, start to have permeability hole 5 on interlayer 10, be provided with the standard solution made in supply chamber 1 on permeability hole 5 and enter the skin model 13 in the standard physiological saline in receiving chamber by penetration mode, it is characterized in that: also be provided with for supplement the replenishing chamber of standard physiological saline to receiving chamber 2, the bottom of replenishing chamber is communicated with receiving chamber 2, and the liquid level in replenishing chamber is higher than the liquid level in receiving chamber 2, in supply chamber 1, be provided with for apply the electrode of electric field to the standard solution process of osmosis.
Offer the slot electrode 401 for laying electrode 4 on the interlayer 10 of described permeability hole 5 both sides, on interior two opposing sidewalls of supply chamber 1, be symmetrical arranged the glass clamp base 7 that is useful on fixed electorde 4.
Described glass clamp base 7 is 12-18mm with the distance of interlayer 10.
Described glass clamp base 7 is 15mm with the distance of interlayer 10.
The 0.8-1.2 that the degree of depth of described slot electrode 401 is electrode 4 thickness doubly.
The degree of depth of described slot electrode 401 is identical with the thickness of electrode 4.
Described skin model 13 is arranged on permeability hole 5 by O-ring seal 14 sealings.
Offer on described receiving chamber 2 sidewalls for extracting the liquid outlet 12 of the rear solution of infiltration, be provided with openable sealing-plug in liquid outlet 12.
In described receiving chamber 2, magnetic stir bar 6 is installed.
Described magnetic stir bar 6 is positioned at the below of permeability hole 5.
In concrete experimentation, at first produce vertical experimental provision on basis, top is supply chamber referred to as for chamber, and bottom is that receiving chamber is referred to as being subject to chamber.Specifically as shown in the part-structure of Fig. 1.During experiment, for the actual useful volume in chamber, can determine according to the experiment concrete condition, for on the left and right sides wall of chamber, a pair of glass clamp base is arranged respectively, and be arranged in the boring of sidewall upper glass folder base, the height of glass clamp base distance means bottom surface is adjustable, wherein gets 15mm comparatively suitable.As shown in Figure 1.
Secondly, produce connected component as replenishing chamber in the left side of above-mentioned vertical experimental provision.The bottom of replenishing chamber communicates with the chamber of being subject to, and whole replenishing chamber does not communicate with supplying chamber.As shown in Figure 4.
Again, being subject between chamber and replenishing chamber is to be communicated with fully, and with for not being communicated with between chamber.Experimental agents only is penetrated into and is subject to ，Shou chamber, chamber variable volume by the permeability hole on interlayer, with reference to related data, can be designed as 125ml.Be subject to chamber, replenishing chamber and interbedded structure and annexation as shown in Figure 4.
The embodiment of experimental provision sandwich portion is as follows: the interlayer size should match with supplying He Shou chamber, chamber, and just is placed between the two.Be designed with the permeability hole of Medicated Permeation on interlayer, the both sides in hole are designed with the groove that a pair of degree of depth is consistent with thickness of electrode, so that electrode embeds wherein.According to the structure function of this experimental provision, the diameter value of this permeability hole should be 40mm, and effectively infiltrating area is 12.56cm
2.One end of two electrodes all is connected to wire, as shown in 3 in Fig. 1,4.
The principle of work of interlayer and accessory structure thereof: after placed is good, glass clamp base fixing skin together with cap rock, O-ring seal.After skin center and permeability hole center superposition place, place O-ring seal and cap rock thereon.Fixedly schematic diagram is as shown in Figure 6 for skin.
Finally, wire bonds, on silver electrode, and is placed on the silver electrode of having welded in slot electrode.
The technical scheme that the present invention is cited and embodiment are not restrictions, in the cited technical scheme of the present invention and embodiment is equal to or the effect same approach is all protected in the present invention scope.
Claims (10)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310467795.2A CN103499519A (en) | 2013-10-10 | 2013-10-10 | Composite physical field transdermal drug delivery experiment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310467795.2A CN103499519A (en) | 2013-10-10 | 2013-10-10 | Composite physical field transdermal drug delivery experiment device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103499519A true CN103499519A (en) | 2014-01-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310467795.2A Pending CN103499519A (en) | 2013-10-10 | 2013-10-10 | Composite physical field transdermal drug delivery experiment device |
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| Country | Link |
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| CN (1) | CN103499519A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109612898A (en) * | 2018-11-12 | 2019-04-12 | 禄根仪器(镇江)有限公司 | A suspending agent flow release test flow chamber |
| WO2019157833A1 (en) * | 2018-02-13 | 2019-08-22 | 常州华佳医疗器械有限公司 | Novel smart transdermal and oral administration equipment and method |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594884A (en) * | 1984-06-21 | 1986-06-17 | Merck & Co., Inc. | Diffusion measuring device |
| US5162042A (en) * | 1988-07-05 | 1992-11-10 | Alza Corporation | Electrotransport transdermal system |
| US5298017A (en) * | 1992-12-29 | 1994-03-29 | Alza Corporation | Layered electrotransport drug delivery system |
| US5356632A (en) * | 1991-09-12 | 1994-10-18 | S.I. Scientific Innovations Ltd. | Transdermal drug delivery device |
| US5533971A (en) * | 1993-09-03 | 1996-07-09 | Alza Corporation | Reduction of skin irritation during electrotransport |
| CN1592644A (en) * | 2001-04-06 | 2005-03-09 | 马蒂奥利工程有限公司 | Apparatus for skin absorption enhancement |
| CN1832778A (en) * | 2003-05-30 | 2006-09-13 | 马蒂奥利工程有限公司 | Methods and devices for enhancing skin absorbency and transdermal delivery of lidocaine and/or other drugs |
| CN1832777A (en) * | 2003-06-02 | 2006-09-13 | 纸型电池有限公司 | Kit, device and method for controlled delivery of oxidizing agent into the skin |
| US20120324984A1 (en) * | 2009-12-01 | 2012-12-27 | Health Protection Agency | Assay method and apparatus |
| CN203551437U (en) * | 2013-10-10 | 2014-04-16 | 河南科技大学 | Composite physical field transdermal drug delivery experimental facility |
-
2013
- 2013-10-10 CN CN201310467795.2A patent/CN103499519A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594884A (en) * | 1984-06-21 | 1986-06-17 | Merck & Co., Inc. | Diffusion measuring device |
| US5162042A (en) * | 1988-07-05 | 1992-11-10 | Alza Corporation | Electrotransport transdermal system |
| US5356632A (en) * | 1991-09-12 | 1994-10-18 | S.I. Scientific Innovations Ltd. | Transdermal drug delivery device |
| US5298017A (en) * | 1992-12-29 | 1994-03-29 | Alza Corporation | Layered electrotransport drug delivery system |
| US5533971A (en) * | 1993-09-03 | 1996-07-09 | Alza Corporation | Reduction of skin irritation during electrotransport |
| CN1592644A (en) * | 2001-04-06 | 2005-03-09 | 马蒂奥利工程有限公司 | Apparatus for skin absorption enhancement |
| CN1832778A (en) * | 2003-05-30 | 2006-09-13 | 马蒂奥利工程有限公司 | Methods and devices for enhancing skin absorbency and transdermal delivery of lidocaine and/or other drugs |
| CN1832777A (en) * | 2003-06-02 | 2006-09-13 | 纸型电池有限公司 | Kit, device and method for controlled delivery of oxidizing agent into the skin |
| US20120324984A1 (en) * | 2009-12-01 | 2012-12-27 | Health Protection Agency | Assay method and apparatus |
| CN203551437U (en) * | 2013-10-10 | 2014-04-16 | 河南科技大学 | Composite physical field transdermal drug delivery experimental facility |
Non-Patent Citations (2)
| Title |
|---|
| 岳奇峰 等: "电致孔条件下不同电学参数对青藤碱透皮给药的影响", 《中草药》, vol. 37, no. 11, 30 November 2006 (2006-11-30), pages 1639 - 1641 * |
| 程昊 等: "电致孔条件下秦艽水提液体外透皮给药最优电学参数的研究", 《中国药学杂志》, vol. 44, no. 22, 30 November 2009 (2009-11-30) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019157833A1 (en) * | 2018-02-13 | 2019-08-22 | 常州华佳医疗器械有限公司 | Novel smart transdermal and oral administration equipment and method |
| CN109612898A (en) * | 2018-11-12 | 2019-04-12 | 禄根仪器(镇江)有限公司 | A suspending agent flow release test flow chamber |
| CN109612898B (en) * | 2018-11-12 | 2021-06-04 | 禄根仪器(镇江)有限公司 | A suspending agent flow release test flow chamber |
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Application publication date: 20140108 |