CN103495019B - A kind of tranquilizing by nourishing the heart Chinese medicine preparation and preparation method thereof - Google Patents
A kind of tranquilizing by nourishing the heart Chinese medicine preparation and preparation method thereof Download PDFInfo
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Abstract
本发明公开了一种养心安神中药制剂及其制备方法，用纯中草药制成制剂，具有补心肾、益肝、健脾胃的功效，通过调节人体脏腑气血功能，益气养血，安神定志，从多环节共同发挥改善睡眠之保健功效。毒副作用小，标本兼治，疗效显著，临床症状消失迅速，治愈后无反弹现象。The invention discloses a traditional Chinese medicine preparation for nourishing the heart and calming the nerves and a preparation method thereof. The preparation is made of pure Chinese herbal medicine, which has the effects of invigorating the heart and kidney, benefiting the liver, and invigorating the spleen and stomach. Determined to exert the health care effect of improving sleep from multiple links. The toxic and side effects are small, the symptoms and root causes are treated, the curative effect is remarkable, the clinical symptoms disappear quickly, and there is no rebound phenomenon after the cure.
Description
技术领域：Technical field:
本发明公开了一种养心安神中药制剂及其制备方法，具有养心安神、清心除烦、疏肝解郁、滋补肝肾的作用，属于中医学制药技术领域。 The invention discloses a traditional Chinese medicine preparation for nourishing the heart and calming the nerves and a preparation method thereof, which has the functions of nourishing the heart and calming the nerves, clearing the heart and relieving restlessness, soothing the liver and relieving stagnation, and nourishing the liver and kidney, and belongs to the technical field of traditional Chinese medicine pharmacy.
背景技术：Background technique:
失眠以睡眠时间不足，睡眠深度不够及不能消除疲劳，恢复体力与精力为主要特征。随着现代人精神压力的增大和药物等因素的不良影响，失眠者的队伍正在悄然壮大。据不完全统计，全世界约有25％的人患有不同程度的失眠症。 Insomnia is mainly characterized by insufficient sleep time, insufficient sleep depth and inability to eliminate fatigue and restore physical strength and energy. With the increase of modern people's mental stress and the adverse effects of drugs and other factors, the ranks of insomniacs are quietly growing. According to incomplete statistics, about 25% of people in the world suffer from insomnia in various degrees.
目前，国内外西医主要采用抗焦虑药物安定类治疗，可改善患者的某些症状，但副作用较大，出现神情抑制，萎靡不振的现象，长期使用造成患者对药物的依赖性，用药可入睡，不用药不能入睡，用药量也逐渐加大疗效不佳。中医认为神经衰弱，虚烦不眠是由肝血不足，血不养心，阴虚内热所致，中医中药在治疗该病上有很大潜力。 At present, Western medicine at home and abroad mainly uses anti-anxiety drugs and diazepam for treatment, which can improve some symptoms of patients, but the side effects are relatively large, and the phenomenon of depression and depression occurs. Long-term use causes the patient's dependence on drugs. Can not fall asleep without medicine, and the dosage of medicine is also gradually increased and the curative effect is not good. Traditional Chinese medicine believes that neurasthenia, fatigue and insomnia are caused by insufficient liver blood, blood not nourishing the heart, and internal heat due to yin deficiency. Traditional Chinese medicine has great potential in treating this disease.
目前国内市场上中药制剂品种少，现有中药制剂品种虽有一定疗效，但药效发挥较慢，很难满足患者的要求。 At present, there are few varieties of traditional Chinese medicine preparations in the domestic market. Although the existing varieties of traditional Chinese medicine preparations have a certain curative effect, the efficacy of the medicines is slow, and it is difficult to meet the requirements of patients.
发明内容 Contents of the invention
本发明的目的在于公开一种养心安神中药制剂及其制备方法，疗效显著，缩短治疗周期，减少治疗费用，提高治疗效果，简化治疗方法。 The object of the present invention is to disclose a traditional Chinese medicine preparation for nourishing the heart and calming the nerves and a preparation method thereof, which has remarkable curative effect, shortens the treatment period, reduces the treatment cost, improves the treatment effect and simplifies the treatment method.
根据祖国中医理论，失眠主要是由于心、胆、脾、肾的阴阳失调，气血失和以致心神失养或心神不安。本发明选用清心除烦、养血安神、健脾解郁、补益肝肾的纯天然中草药，调整人体脏腑气血的功能，从而达到安神定志，改善睡眠的目的。 According to the theory of traditional Chinese medicine in China, insomnia is mainly due to the imbalance of yin and yang in the heart, gallbladder, spleen, and kidney, and the imbalance of qi and blood, resulting in lack of nourishment or restlessness of the mind. The present invention selects pure natural Chinese herbal medicines for clearing the heart and relieving restlessness, nourishing blood and calming the nerves, invigorating the spleen and relieving stagnation, and nourishing the liver and kidneys to adjust the functions of qi and blood in the viscera of the human body, so as to calm the nerves and calm the mind, and improve sleep.
本发明公开的一种养心安神中药制剂，是由以下原料按重量份数比制成的：A traditional Chinese medicine preparation for nourishing the heart and calming the nerves disclosed by the present invention is prepared from the following raw materials according to the ratio of parts by weight:
黄连15～20、阿胶15～20、柴胡15～20、枳壳15～20、青皮15～20、生地15～20、茯苓15～20、麦冬15～20、珍珠母50～60、远志15～20、炒枣仁50～60、龙齿3～5、琥珀7～10、丹参15～20、夜交藤15～20。 Coptis 15-20, Ejiao 15-20, Bupleurum 15-20, Citrus aurantium 15-20, Qingpi 15-20, Rehmannia 15-20, Poria cocos 15-20, Ophiopogon japonicus 15-20, Mother-of-pearl 50-60, Polygala 15-20, fried jujube kernel 50-60, dragon tooth 3-5, amber 7-10, salvia miltiorrhiza 15-20, vine 15-20.
本发明药物的优选配比为： The preferred proportioning of medicine of the present invention is:
黄连20、阿胶20、柴胡20、枳壳20、青皮20、生地20、茯苓20、麦冬20、珍珠母60、远志20、炒枣仁60、龙齿5、琥珀10、丹参20、夜交藤20。 Coptidis 20, Ejiao 20, Bupleurum 20, Citrus aurantium 20, Qingpi 20, Rehmannia 20, Poria cocos 20, Ophiopogon japonicus 20, Mother of pearl 60, Polygala 20, Fried jujube kernel 60, Dragon tooth 5, Amber 10, Salvia miltiorrhiza 20, Night Koto 20.
本发明公开的养心安神中药制剂的制备方法，包括以下步骤：The preparation method of the traditional Chinese medicine preparation for nourishing the heart and calming the nerves disclosed by the invention comprises the following steps:
如下按重量份数称取上述原料，除去杂物后，粉碎成100～200目细粉，即得。 The above-mentioned raw materials are weighed in parts by weight as follows, and after removing impurities, they are crushed into fine powders of 100-200 meshes to obtain the final product.
用法用量：口服，3次/日；5～8克/次，15天为一个疗程。 Usage and dosage: Oral, 3 times/day; 5-8 grams/time, 15 days as a course of treatment.
功能：养心安神、舒肝解郁、滋补肝肾。 Function: Nourish the heart and calm the nerves, soothe the liver and relieve depression, nourish the liver and kidney.
主治：失眠多梦、心烦心悸、乏力、口干耳呜、善太息、健忘、腰膝痠软、尿频等。 Indications: Insomnia and dreaminess, upset and palpitations, fatigue, dry mouth and tinnitus, sativa, forgetfulness, soreness of the waist and knees, frequent urination, etc.
本发明按照“君、臣、佐、使”的配伍原则，使各药之间相需为用，共同发挥治疗作用。琥珀、黄连、阿胶交通心肾、镇静安神之作用，用于虚烦不眠，惊悸多梦；柴胡、枳壳、青皮、茯苓疏肝解郁、健脾安神之效；生地、麦冬滋阴补肾；珍珠母、龙齿配合使用起安神定惊的作用；丹参、夜交藤、远志、炒枣仁诸药配合使用共同起到养心血而无流滞之蔽，安心神而具解郁之功。达到养心安神镇静、清心除烦解郁之效，从而改善睡眠质量。 According to the compatibility principle of "lord, minister, assistant, and envoy", the present invention makes the medicines use each other as needed to jointly exert therapeutic effects. Amber, coptis, donkey-hide gelatin communicate the heart and kidney, calm and soothe the nerves, and are used for restlessness, insomnia, palpitation and dreaminess; Bupleurum, Citrus aurantium, Qingpi, Poria soothe the liver and relieve depression, invigorate the spleen and calm the nerves; Shengdi, Radix Nourishing Yin Invigorate the kidney; mother of pearl and dragon tooth can calm the nerves and calm convulsions; the combination of salvia miltiorrhiza, night jelly vine, polygala, and fried jujube kernel can nourish the heart and blood without stagnation, soothe the mind and relieve depression achievement. Achieve the effect of nourishing the mind, calming the nerves, clearing the heart, eliminating troubles and relieving depression, thereby improving the quality of sleep.
为表明本发明药物的治疗效果，入选100例睡眠障碍者，服用本发明药品进行治疗，经系统临床观察进行统计分析总结如下： For showing the therapeutic effect of medicine of the present invention, select 100 routine sleep disorders, take medicine of the present invention to treat, carry out statistical analysis through systematic clinical observation and summarize as follows:
一、临床表现 1. Clinical manifestations
失眠多梦、心烦心悸、乏力、口干耳呜、善太息、健忘惊悸、腰膝痠软、尿频、神志恍惚、睡眠障碍。 Insomnia and dreaminess, upset and palpitations, fatigue, dry mouth and tinnitus, sativa, forgetfulness and palpitations, sore waist and knees, frequent urination, trance, sleep disorders.
二、疗效判定标准 2. Efficacy Judgment Criteria
临床治愈：各种症状均消失 。 Clinical cure: all symptoms disappeared.
显效：各种症状明显改善。 Significantly effective: various symptoms were significantly improved.
有效：各种症状有所改善。 Effective: Various symptoms have been improved.
无效：各种症状无改变。 Ineffective: no change in various symptoms.
三、治疗结果 3. Treatment results
100例睡眠障碍患者，临床治愈65例（65%）；显效28例（28%）；有效7例（7%）；无效0例。总有效率为100%。 Among 100 patients with sleep disorders, 65 cases (65%) were clinically cured; 28 cases (28%) were markedly effective; 7 cases (7%) were effective; and 0 cases were ineffective. The total effective rate is 100%.
本发明的积极效果在于：The positive effects of the present invention are:
选用纯中草药制成制剂，具有补心肾、益肝、健脾胃的功效，通过调节人体脏腑气血功能，益气养血，安神定志，从多环节共同发挥改善睡眠之保健功效。毒副作用小，标本兼治，疗效显著，临床症状消失迅速，治愈后无反弹现象。 The preparation is made of pure Chinese herbal medicine, which has the effects of invigorating the heart and kidney, nourishing the liver, and invigorating the spleen and stomach. By regulating the functions of qi and blood in the human viscera, nourishing qi and blood, calming the nerves and calming the mind, it exerts the health care effect of improving sleep from multiple links. The toxic and side effects are small, the symptoms and root causes are treated, the curative effect is remarkable, the clinical symptoms disappear quickly, and there is no rebound phenomenon after the cure.
具体实施方式：Detailed ways:
通过以下实施例进一步举例描述本发明，并不以任何方式限制本发明，在不背离本发明的技术解决方案的前提下，对本发明所作的本领域普通技术人员容易实现的任何改动或改变都将落入本发明的权利要求范围之内。 Further illustrate the present invention by the following examples, do not limit the present invention in any way, under the premise of not departing from the technical solution of the present invention, any modification or change that those of ordinary skill in the art that the present invention is done to realize easily will all be fall within the scope of the claims of the present invention.
实施例1Example 1
称取黄连15g、阿胶15g、柴胡15g、枳壳15g、青皮15g、生地15g.茯苓15g、麦冬15g、珍珠母50g、远志15g、炒枣仁50g、龙齿3g、琥珀7g、丹参15g、夜交藤15g除去杂物后，粉碎成100目细粉，其他项应符合中华人民共和国2000年版药典细粉项下。 Weigh 15g Coptidis, 15g Ejiao, 15g Bupleurum, 15g Citrus aurantii, 15g Qingpi, 15g Rehmannia, 15g Poria, 15g Ophiopogon japonicus, 50g mother-of-pearl, 15g Polygala, 50g fried jujube kernel, 3g dragon tooth, 7g amber, 15g salvia miltiorrhiza 15g of Caulis japonica, after removing impurities, crushed into 100-mesh fine powder, other items should comply with the 2000 edition of the Pharmacopoeia of the People's Republic of China under the fine powder item.
实施例2Example 2
取黄连20g、阿胶20g、柴胡20g、枳壳20g、青皮20g、生地20g、茯苓20g、麦冬20g、珍珠母60g、远志20g、炒枣仁60g、龙齿5g、琥珀10g、丹参20g、夜交藤20g除去杂物后，粉碎成150目细粉，其他项应符合中华人民共和国2000年版药典细粉项下。 Take 20g Coptidis, 20g Ejiao, 20g Bupleurum, 20g Citrus aurantii, 20g Qingpi, 20g Rehmannia, 20g Poria, 20g Ophiopogon japonicus, 60g mother-of-pearl, 20g Polygala, 60g fried jujube kernel, 5g dragon tooth, 10g amber, 20g salvia miltiorrhiza, 20g of Caulis japonica has been removed from impurities, then crushed into 150 mesh fine powder, and other items shall comply with the 2000 edition of the Pharmacopoeia of the People's Republic of China under the fine powder item.
实施例3Example 3
取黄连18g、阿胶18g、柴胡18g、枳壳18g、青皮18g、生地18g、茯苓18g、麦冬18g、珍珠母55g、远志18g、炒枣仁55g、龙齿4g、琥珀8g、丹参18g、夜交藤18g除去杂物后，粉碎成100～200目细粉，其他项应符合中华人民共和国2000年版药典细粉项下。 Take Coptidis 18g, Ejiao 18g, Bupleurum 18g, Citrus aurantium 18g, Qingpi 18g, Rehmannia 18g, Poria cocos 18g, Ophiopogon japonicus 18g, mother-of-pearl 55g, Polygala 18g, fried jujube kernel 55g, dragon tooth 4g, amber 8g, salvia miltiorrhiza 18g, After removing the sundries, 18g of Caulis japonica is crushed into a fine powder of 100-200 mesh, and other items shall comply with the fine powder items of the Pharmacopoeia of the People's Republic of China in 2000.
精选以下病例进一步说明本发明疗效：Select the following cases to further illustrate the curative effect of the present invention:
病例１Case 1
朱某，男，18岁，学生，以“睡眠障碍”来就诊。就诊证候：心烦不寐，唇焦面红，渴喜冷饮，四肢微微抽动，小便黄少，舌红、苔少，脉沉细而数。通过本发明药物治疗，口服3次/日，6克/次，15天为1疗程，共2个疗程，病症皆瘥。随访12个月，病情未复发。 Zhu, male, 18 years old, student, came to see a doctor with "sleep disorder". Symptoms of treatment: upset and insomnia, burnt lips and red face, thirsty for cold drinks, slight twitching of limbs, less yellow urine, red tongue with less coating, deep thready and rapid pulse. By drug treatment of the present invention, oral administration 3 times/day, 6 grams/time, 15 days are 1 course for the treatment of, totally 2 courses for the treatment of, and disease all recovers. Follow up a case by regular visits to 12 months, the state of an illness does not recur.
病例２Case 2
李某，男，37岁，公务员，以“睡眠障碍”来就诊。就诊证候：夜不入寐，心悸而烦，咽干口燥，手足心热，舌红、少苔，脉细而数。通过本发明药物治疗，口服3次/日，8克/次，15天为1疗程，共3个疗程，病症皆瘥。随访12个月，病情未复发。 Li, male, 37 years old, civil servant, came to see a doctor with "sleep disorder". Symptoms of treatment: sleepless nights, palpitations and restlessness, dry throat, dry mouth, hot hands, feet, heart, red tongue, little moss, thready and rapid pulse. By drug treatment of the present invention, oral administration 3 times/day, 8 grams/time, 15 days are 1 course for the treatment of, totally 3 courses for the treatment of, and disease all recovers. Follow up a case by regular visits to 12 months, the state of an illness does not relapse.
病例3Case 3
白某，女，46岁，部门经理，以“睡眠障碍”来就诊。就诊证候：既往患神经官能症8年，遍服安神镇静之剂少效，半月前，彻夜不眠，难以入睡，头晕耳鸣，潮热盗汗，五心烦热，腰膝酸软，舌红、少苔，脉沉细数。通过本发明药物治疗，口服3次/日，8克/次，15天为1疗程，共5个疗程，病症皆瘥。随访12个月，病情未复发。 Bai, female, 46 years old, department manager, came to see a doctor with "sleep disorder". Symptoms at the doctor: I have been suffering from neurosis for 8 years, and I have been taking sedatives and sedatives with little effect. Half a month ago, I was sleepless all night, difficult to fall asleep, dizziness and tinnitus, hot flashes and night sweats, five upset and hot, sore waist and knees, red tongue, less coating , pulse slowly. By drug treatment of the present invention, oral administration 3 times/day, 8 grams/time, 15 days are 1 course for the treatment of, totally 5 courses for the treatment of, and disease all recovers. Follow up a case by regular visits to 12 months, the state of an illness does not recur.
病例4Case 4
余某，女，54岁，农民，以“睡眠障碍”来就诊。就诊证候：心烦少寐，咽干口燥，手足心热，形体消瘦，头晕目眩，舌红、少苔，脉细数。通过本发明药物治疗，口服3次/日，8克/次，15天为1疗程，病症皆瘥。随访12个月，病情未复发。 Yu Mou, female, 54 years old, a farmer, came to see a doctor with "sleep disorder". Symptoms of visiting a doctor: restlessness, less sleepiness, dry throat, dry mouth, hot hands, feet, heart, emaciation, dizziness, red tongue, little coating, thready and rapid pulse. By drug treatment of the present invention, oral administration 3 times/day, 8 grams/time, 15 days are 1 course of treatment, and disease all recovers. Follow up a case by regular visits to 12 months, the state of an illness does not relapse.
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