CN103417654A - Traditional Chinese medicine composition for preventing and controlling poultry coccidiosis and preparation method of same - Google Patents
Traditional Chinese medicine composition for preventing and controlling poultry coccidiosis and preparation method of same Download PDFInfo
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Abstract
The invention aims at solving the technical problems that the traditional medicine for treating coccidiosis has a low medicinal curative effect and residues and affects the quality of poultry products. In order to solve the problem, the invention provides a traditional Chinese medicine composition for preventing and controlling poultry coccidiosis and a preparation method of the composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 80-160 parts of artemisia apiacea, 80-160 parts of antifebrile dichroa, 60-120 parts of radix bupleuri, 60-120 parts of Chinese pulsatilla root and 60-120 parts of astragalus membranaceus. The traditional Chinese medicine composition can effectively treat and prevent the poultry coccidiosis, is conveniently used, and does not have toxic or side effect and medicine residues after the medicine is admisitered.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition of preventing and treating the birds coccidiosis and preparation method thereof.
Background technology
The birds coccidiosis is the most serious a kind of common transmittable disease to birds harm caused by coccidiosis, wherein serious with the coccidiosis of chicken, duck, but this disease is equal eruption and prevalences throughout the year, take clinically diarrhoea, arrange red feces as feature, mortality rate can be up to 80%, the poultry growth retardation of recovering, weightening finish slowly, Abwehrkraft des Koepers reduces, and easily suffers from Other diseases, very large to the harm of poultry.The loss that whole world every year causes because of coccidiosis is up to 1,500,000,000 dollars, and coccidiosis has become the global disease of obstruction set reduction avian production development.
The pathogen of primary disease is to parasitize the epithelial unicellular protozoon of intestinal mucosa, belongs to protozoa, has 9 kinds.This disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be that various antibacterials and anticoccidial are specially controlled medicine, as sulfa drugs, oxytetracycline, Salinomycin, nicarbazine, diclazuril etc.; Due to the prolonged and repeated use of these medicines, cause this pathogenic microorganism to produce drug resistance to medicine, reduced curative effect, and drug residue is in animal body, its meat does not reach nuisanceless requirement, has affected the outlet of poultry product and people's health.
Summary of the invention
The technical problem to be solved in the present invention is that the curative effect of medication of traditional treatment coccidiosis is low, have residual, affect the quality of poultry product, for addressing the above problem, a kind of Chinese medicine composition of preventing and treating the birds coccidiosis and preparation method thereof is provided, can effectively treat and prevent coccidiosis of domestic fowls, and easy to use, after medication, have no side effect and drug residue.
Technical scheme of the present invention realizes in the following manner:
A kind of Chinese medicine composition of preventing and treating the birds coccidiosis, it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 80-160 part, Radix Dichroae 80-160 part, Radix Bupleuri 60-120 part, Radix Pulsatillae 60-120 part, Radix Astragali 60-120 part.
Further, limiting it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 90-140 part, Radix Dichroae 90-140 part, Radix Bupleuri 70-100 part, Radix Pulsatillae 70-100 part, Radix Astragali 70-100 part.
Further, limiting it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 100-120 part, Radix Dichroae 100-120 part, Radix Bupleuri 80-90 part, Radix Pulsatillae 80-90 part, Radix Astragali 80-90 part.
Further, limiting it is prepared from by the raw material of following weight portion: 110 parts of Herba Artemisiae Annuaes, 110 parts of Radix Dichroaes, 85 parts of Radix Bupleuri, 85 parts of the Radix Pulsatillaes, 85 parts of the Radixs Astragali.
Further again, the dosage form that limits it is any in powder, tablet, granule, oral liquid or injection.
A kind of preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 80-160 part, Radix Dichroae 80-160 part, Radix Bupleuri 60-120 part, Radix Pulsatillae 60-120 part, Radix Astragali 60-120 part.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 60%～80% alcoholic solution of 3～8 times of weight, reflux, extract, 1～4 time, each 1～3 hour, temperature was 40～80 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add the water of 6～12 times of weight, decoct 1～3 time, each 1～3 hour, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.20～1.25g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add conventional adjuvant, be prepared from.
Further, limiting it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 90-140 part, Radix Dichroae 90-140 part, Radix Bupleuri 70-100 part, Radix Pulsatillae 70-100 part, Radix Astragali 70-100 part.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add the 70%-80% alcoholic solution of 4-7 times of weight, reflux, extract, 2-3 time, each 2-3 hour, temperature is 50 ℃-70 ℃, filters, merging filtrate, concentrate to obtain alcohol extract;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add the water of 7-10 times of weight, decoct 2-3 hour, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.23～1.24 g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add conventional adjuvant, be prepared from.
Further, limiting it comprises the steps:
(1) take the raw material of following weight portion: 100 parts of Herba Artemisiae Annuaes, 100 parts of Radix Dichroaes, 80 parts of Radix Bupleuri, 80 parts of the Radix Pulsatillaes, 80 parts of the Radixs Astragali.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 80% alcoholic solution of 4 times of weight, reflux, extract, 4 times, each 1 hour, temperature was 60 ℃, filtered, merging filtrate, concentrate to obtain alcohol extract;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add the water of 10 times of weight, decoct 2 hours, and then add the water of 6 times of amounts of three's weight summation, decoct 2 hours, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.20～1.25 g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add conventional adjuvant, be prepared from.
The pharmacological property of each component of the present invention is as follows: Herba Artemisiae Annuae bitter in the mouth, suffering, and cold in nature, return liver, gallbladder meridian, three warmers, kidney channel, function cures mainly: clear deficiency-heat thoroughly, removing heat from blood is except steaming, and preventing the attack (or recurrence) of malaria, for pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat; Radix Dichroae bitter in the mouth, suffering, cold in nature, poisonous, function cures mainly: preventing the attack (or recurrence) of malaria, rob expectorant, for malaria; The Radix Bupleuri cold nature, bitter in the mouth, suffering, return
Liver Channel, gallbladder meridian, the tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire, function cures mainly: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy; Radix Pulsatillae bitter in the mouth, cold in nature, return stomach warp, large intestine channel, function cures mainly: there is heat-clearing and toxic substances removing,
Removing heat from bloodDysentery relieving, the effect of removing dampness and killing parasites, cure mainly pyretic toxicity dysentery, removing heat from blood, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, scrofula; Radix Astragali sweet in the mouth, slightly warm in nature, return liver,
Spleen,
Lung, kidney channel, have that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, an effect of holder skin ulcer granulation promoting, inducing diuresis to remove edema.
With respect to prior art, the present invention be take Radix Dichroae and Herba Artemisiae Annuae as main, and is aided with heat clearing away, hemostasis, dehumidifying class medicine Radix Bupleuri, the Radix Pulsatillae and the Radix Astragali, clinically mainly with the form of powder or powder, takes the mode of spice or drinking-water to use.In the present invention, Radix Dichroae and Herba Artemisiae Annuae adopt alcohol extraction, and Radix Bupleuri, the Radix Pulsatillae and the Radix Astragali adopt water extraction, merge alcohol extract and water extraction liquid, are condensed into thick extractum and add adjuvant and make dosage forms.The present invention has fully extracted various middle the effective elements of the medicines, the medicine stability made is good, control birds coccidiosis is effective, cure rate is high, intestinal pathological changes after medication, the pathological changes such as hemorrhage significantly descend, body weight obviously increases, and is a kind of good effect, nuisanceless, noresidue, medicine easy to use.
The specific embodiment
Embodiment 1:
A kind of Chinese medicine composition of preventing and treating the birds coccidiosis, it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 80g, Radix Dichroae 80g, Radix Bupleuri 60g, Radix Pulsatillae 60g, Radix Astragali 60g.
A kind of preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 80g, Radix Dichroae 80g, Radix Bupleuri 60g, Radix Pulsatillae 60g, Radix Astragali 60g.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 60% alcoholic solution of 3 times of Radix Dichroaes and Herba Artemisiae Annuae weight, reflux, extract, 1 time, one time 1 hour, temperature was 40 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add the water of 6 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, decoct 1 time, one time 1 hour, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.20g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, and lyophilization becomes dried cream powder, then adds glucose powder, makes powder.
Embodiment 2:
A kind of Chinese medicine composition of preventing and treating the birds coccidiosis, it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 80g, Radix Dichroae 80g, Radix Bupleuri 60g, Radix Pulsatillae 60g, Radix Astragali 60g.
A kind of preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 90g, Radix Dichroae 90g, Radix Bupleuri 65g, Radix Pulsatillae 65g, Radix Astragali 65g.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 65% alcoholic solution of 4 times of Radix Dichroaes and Herba Artemisiae Annuae weight, reflux, extract, 2 times, one time 1.5 hours, temperature was 45 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add the water of 7 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, decoct 2 times, one time 1.5 hours, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.21g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add glucose powder, starch and binding agent, and granulate, drying, granulate, granulation.
Embodiment 3:
A kind of Chinese medicine composition of preventing and treating the birds coccidiosis, it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 100g, Radix Dichroae 100g, Radix Bupleuri 75g, Radix Pulsatillae 75g, Radix Astragali 75g.
A kind of preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 100g, Radix Dichroae 100g, Radix Bupleuri 75g, Radix Pulsatillae 75g, Radix Astragali 75g.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 70% alcoholic solution of 5 times of Radix Dichroaes and Herba Artemisiae Annuae weight, reflux, extract, 3 times, one time 2 hours, temperature was 50 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add the water of 8 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, decoct 3 times, one time 2 hours, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.22g ∕ ml that filtrate is concentrated to density, and the thick extractum that temperature is 60 ℃, add glucose powder, starch and magnesium stearate, makes tablet.
Embodiment 4:
A kind of Chinese medicine composition of preventing and treating the birds coccidiosis, it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 110g, Radix Dichroae 110g, Radix Bupleuri 85g, Radix Pulsatillae 85g, Radix Astragali 85g.
A kind of preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 110g, Radix Dichroae 110g, Radix Bupleuri 85g, Radix Pulsatillae 85g, Radix Astragali 85g.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 75% alcoholic solution of 5.5 times of Radix Dichroaes and Herba Artemisiae Annuae weight, reflux, extract, 4 times, one time 2.5 hours, temperature was 55 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add the water of 9 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, decoct 3 times, one time 2.5 hours, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.23g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add glucose powder, starch and dextrin, and granulate, drying, granulate, granulation.
Embodiment 5:
A kind of Chinese medicine composition of preventing and treating the birds coccidiosis, it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 120g, Radix Dichroae 120g, Radix Bupleuri 95g, Radix Pulsatillae 95g, Radix Astragali 95g.
A kind of preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 120g, Radix Dichroae 120g, Radix Bupleuri 95g, Radix Pulsatillae 95g, Radix Astragali 95g.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 80% alcoholic solution of 6 times of Radix Dichroaes and Herba Artemisiae Annuae weight, reflux, extract, 4 times, one time 3 hours, temperature was 60 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add the water of 10 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, decoct 3 times, one time 3 hours, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.24g ∕ ml that filtrate is concentrated to density, and precipitate with ethanol filters, add sucrose, tween 80 and benzyl alcohol, add water to 1000ml, stir, regulate PH to 5.5-7.0, stir evenly, filter, embedding, sterilizing, make oral liquid.
Embodiment 6:
A kind of Chinese medicine composition of preventing and treating the birds coccidiosis, it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 130g, Radix Dichroae 130g, Radix Bupleuri 105g, Radix Pulsatillae 105g, Radix Astragali 105g.
A kind of preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 130g, Radix Dichroae 130g, Radix Bupleuri 105g, Radix Pulsatillae 105g, Radix Astragali 105g.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 75% alcoholic solution of 6.5 times of Radix Dichroaes and Herba Artemisiae Annuae weight, reflux, extract, 4 times, one time 3 hours, temperature was 65 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add the water of 11 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, decoct 3 times, one time 3 hours, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.24g ∕ ml that filtrate is concentrated to density, and precipitate with ethanol filters, and adds tween 80 and benzyl alcohol, adds water to 1000ml, stirs, and regulates PH to 5.5-7.0, stirs evenly, filter, and embedding, sterilizing, make injection.
Embodiment 7:
A kind of Chinese medicine composition of preventing and treating the birds coccidiosis, it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 140g, Radix Dichroae 140g, Radix Bupleuri 110g, Radix Pulsatillae 110g, Radix Astragali 110g.
A kind of preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 140g, Radix Dichroae 140g, Radix Bupleuri 110g, Radix Pulsatillae 110g, Radix Astragali 110g.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 75% alcoholic solution of 7 times of Radix Dichroaes and Herba Artemisiae Annuae weight, reflux, extract, 4 times, one time 3 hours, temperature was 70 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add the water of 12 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, decoct 3 times, one time 3 hours, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.25g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add sucrose and dextrin, the granulation agent.
Embodiment 8:
A kind of Chinese medicine composition of preventing and treating the birds coccidiosis, it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 150g, Radix Dichroae 150g, Radix Bupleuri 115g, Radix Pulsatillae 115g, Radix Astragali 115g.
A kind of preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 150g, Radix Dichroae 150g, Radix Bupleuri 115g, Radix Pulsatillae 115g, Radix Astragali 115g.
(2) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 80% alcoholic solution of 4 times of Radix Dichroaes and Herba Artemisiae Annuae weight, reflux, extract, 4 times, one time 1 hour, temperature was 60 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add for the first time the water of 10 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, add for the second time the water of 6 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, decoct 2 times, one time 2 hours, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.25g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add the adjuvants such as glucose, starch, sodium carboxymethyl cellulose, make tablet.
Embodiment 9:
A kind of Chinese medicine composition of preventing and treating the birds coccidiosis, it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 160g, Radix Dichroae 160g, Radix Bupleuri 120g, Radix Pulsatillae 120g, Radix Astragali 120g.
A kind of preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it comprises the steps:
(3) take the raw material of following weight portion: Herba Artemisiae Annuae 160g, Radix Dichroae 160g, Radix Bupleuri 120g, Radix Pulsatillae 120g, Radix Astragali 120g.
(4) get the above-mentioned Herba Artemisiae Annuae taken and Radix Dichroae raw material, add 80% alcoholic solution of 4 times of Radix Dichroaes and Herba Artemisiae Annuae weight, reflux, extract, 4 times, one time 1 hour, temperature was 60 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get the above-mentioned Radix Bupleuri taken, the Radix Pulsatillae and Radix Astragali raw material, add for the first time the water of 10 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, add for the second time the water of 6 times of Radix Bupleuri, the Radix Pulsatillae and astragalus weights, decoct 2 times, one time 2 hours, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) above-mentioned alcohol extract and water extraction liquid are mixed, filter, it is 1.25g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add the adjuvants such as glucose, starch, sodium carboxymethyl cellulose, make tablet.
1, Radix Dichroae and Herba Artemisiae Annuae extraction process is preferred
Radix Dichroae and Herba Artemisiae Annuae adopt alcohol extraction, with the preferred optimum extraction process of orthogonal experiment, according to related data and preliminary experiment, choose four principal elements that affect extraction effect: concentration of alcohol (A), ethanol consumption (B), extraction time (C), return time (D), each factor is respectively selected 3 levels, in Table one.Select orthogonal array L
9(3
4) arrange test, the results are shown in Table two.Each test all repeats 3 times.The investigation index is artemislnin content (g/100g crude drug) and extractum rate (g/100g dry extract).
Table one factor level table
Table two orthogonal and intuitive analysis
Process variance and range analysis also considered practical condition, and optimizing the optimum extraction scheme is 4 times of amount 80% ethanol, reflux, extract, 4 times, and each 1 hour, the process stabilizing preferably obtained was feasible, can be used for reference in actual production.
Clinical trial one:
Zhumadian one raiser, raise table hens 3500, raised according to a conventional method, occur that when 25 age in days spirit is depressed, disorderly, feed intake descends the feather pine, the wattle of chicken is peony, it is reddish yellow that a small amount of feces is arranged, and the feather faecal contamination of anus below, dissect 8 of disease chicken and dead chickens altogether, visible glandular stomach nipple is needle point sample petechia, small intestinal mucosa has island shape ulcer, and the ileum wall has petechia, the cecal tonsil enlargement, in caecum, have hemorrhage, renomegaly, have gelatin mucus thing in trachea, be diagnosed as coccidiosis.Add this product 2g that embodiment 1 makes in every 1L water, 2 times on the one, freely drink, be used in conjunction 3-5 days, symptom disappears substantially, and it is normal that the chicken group recovers.
Clinical trial two:
Table mountain raiser, 5000 of white plumage broiler, raised according to a conventional method, when 35 age in days, sick chicken is slow-witted vertical, and feather is slightly random, loss of appetite, defecate thin, and with a small amount of blood or be bloody stool entirely, thirsty wish increase of later stage, mucosal pallor, cutaneous pigmentation is bad, color and luster is pale, two days dead more than 40.Dissect as seen, sick chicken becomes thin, dehydration, muscle are pale, the caecum enlargement, and enteral is full of blood or white caseous substance, can be diagnosed as Caecum Coccidiosis.Medicine by using embodiment 2 to make, add this medicine 2g according to every 1L water, for sick chicken, drinks, and medication is after five days, and chicken group situation is obviously improved, and dead chicken do not occur.
Clinical trial three:
The Xinyang raiser, raise 3000 of dish ducks, raised according to a conventional method, when 20 age in days, slightly disorderly, loss of appetite, defecate thin feather, and with a small amount of blood or be bloody stool entirely, dissect as seen, enteral is full of blood or white caseous substance, can be diagnosed as Caecum Coccidiosis.Medicine by using embodiment 5 to make, add this medicine 4g according to every 2L water, for sick duck, drinks, and medication is after 10 days, and duck group situation is obviously improved, and dead duck do not occur.
Clinical trial four:
The Nanyang raiser, raise 2500 of white gooses, according to conventional method, raised, and when 10 age in days, shows lassitude, and wing is sagging, and anorexia is extremely weak and become thin, diarrhoea, and excrement is rare or red mucus arranged.Dissect as seen, enteral is full of blood or white caseous substance, can be diagnosed as Caecum Coccidiosis.Medicine by using embodiment 8 to make, add this medicine 2g according to every 1L water, for sick goose, drinks, and medication is after 7 days, and the gaggle situation is obviously improved, and recovers normal.
Claims (8)
1. a Chinese medicine composition of preventing and treating the birds coccidiosis, it is characterized in that: it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 80-160 part, Radix Dichroae 80-160 part, Radix Bupleuri 60-120 part, Radix Pulsatillae 60-120 part, Radix Astragali 60-120 part.
2. the Chinese medicine composition of control according to claim 1 birds coccidiosis, it is characterized in that: it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 90-140 part, Radix Dichroae 90-140 part, Radix Bupleuri 70-100 part, Radix Pulsatillae 70-100 part, Radix Astragali 70-100 part.
3. the Chinese medicine composition of control according to claim 1 birds coccidiosis, it is characterized in that: it is prepared from by the raw material of following weight portion: Herba Artemisiae Annuae 100-120 part, Radix Dichroae 100-120 part, Radix Bupleuri 80-90 part, Radix Pulsatillae 80-90 part, Radix Astragali 80-90 part.
4. the Chinese medicine composition of control according to claim 1 birds coccidiosis, it is characterized in that: it is prepared from by the raw material of following weight portion: 110 parts of Herba Artemisiae Annuaes, 110 parts of Radix Dichroaes, 85 parts of Radix Bupleuri, 85 parts of the Radix Pulsatillaes, 85 parts of the Radixs Astragali.
5. according to the Chinese medicine composition of described any control birds coccidiosis of claim 1 to 4, it is characterized in that: its dosage form is any in powder, tablet, granule, oral liquid or injection.
6. a preparation method of preventing and treating the Chinese medicine composition of birds coccidiosis, it is characterized in that: it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 80-160 part, Radix Dichroae 80-160 part, Radix Bupleuri 60-120 part, Radix Pulsatillae 60-120 part, Radix Astragali 60-120 part;
(2) get Herba Artemisiae Annuae and the Radix Dichroae raw material that step (1) takes, once add 60%～80% alcoholic solution of 3～8 times of weight, reflux, extract, 1～4 time, each 1～3 hour, temperature was 40～80 ℃, filtered merging filtrate, the concentrated alcohol extract that to obtain;
(3) get Radix Bupleuri, the Radix Pulsatillae and the Radix Astragali raw material that step (1) takes, once add the water of 6～12 times of weight, decoct 1～3 time, each 1～3 hour, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) alcohol extract step (2) and step (3) obtained and water extraction liquid mix, and filter, and it is 1.20～1.25g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add conventional adjuvant, be prepared from.
7. the preparation method of the Chinese medicine composition of control according to claim 5 birds coccidiosis, it is characterized in that: it comprises the steps:
(1) take the raw material of following weight portion: Herba Artemisiae Annuae 90-140 part, Radix Dichroae 90-140 part, Radix Bupleuri 70-100 part, Radix Pulsatillae 70-100 part, Radix Astragali 70-100 part;
(2) get Herba Artemisiae Annuae and the Radix Dichroae raw material that step (1) takes, once add the 70%-80% alcoholic solution of 4-7 times of weight, reflux, extract, 2-3 time, each 2-3 hour, temperature is 50 ℃-70 ℃, filters, merging filtrate, concentrate to obtain alcohol extract;
(3) get Radix Bupleuri, the Radix Pulsatillae and the Radix Astragali raw material that step (1) takes, once add the water of 7-10 times of weight, decoct 2-3 hour, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) alcohol extract step (2) and step (3) obtained and water extraction liquid mix, and filter, and it is 1.23～1.24 g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add conventional adjuvant, be prepared from.
8. the preparation method of the Chinese medicine composition of control according to claim 5 birds coccidiosis, it is characterized in that: it comprises the steps:
(1) take the raw material of following weight portion: 100 parts of Herba Artemisiae Annuaes, 100 parts of Radix Dichroaes, 80 parts of Radix Bupleuri, 80 parts of the Radix Pulsatillaes, 80 parts of the Radixs Astragali;
(2) get Herba Artemisiae Annuae and the Radix Dichroae raw material that step (1) takes, once add 80% alcoholic solution of 4 times of weight, reflux, extract, 4 times, each 1 hour, temperature was 60 ℃, filtered, merging filtrate, concentrate to obtain alcohol extract;
(3) get Radix Bupleuri, the Radix Pulsatillae and the Radix Astragali raw material that step (1) takes, add the water of 10 times of weight, decoct 2 hours, and then add the water of 6 times of amounts of three's weight summation, decoct 2 hours, filter, merging filtrate, concentrate to obtain water extraction liquid;
(4) alcohol extract step (2) and step (3) obtained and water extraction liquid mix, and filter, and it is 1.20～1.25 g ∕ ml that filtrate is concentrated to density, the thick extractum that temperature is 60 ℃, then add appropriate glucose powder and starch, be prepared from.
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