CN103417494B - A kind of micropill using tartaric acid as main component - Google Patents
A kind of micropill using tartaric acid as main component Download PDFInfo
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- CN103417494B CN103417494B CN201310361565.8A CN201310361565A CN103417494B CN 103417494 B CN103417494 B CN 103417494B CN 201310361565 A CN201310361565 A CN 201310361565A CN 103417494 B CN103417494 B CN 103417494B
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- tartaric acid
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Abstract
The invention discloses a kind of micropill using tartaric acid as main component, it selects content more than 98% tartaric acid as primary raw material, adds microcrystalline Cellulose, polyvidone class as binding agent, adds starch as diluent, add foaming agent simultaneously, be made into micropill by centrifugal granulating technique.The micropill using tartaric acid as main component adopting composition and engineering of the present invention to make, the various gastric solubilities that can be made into, enteric solubility pill, it not only has the good advantage of drug release reproducibility, and has the features such as easy to prepare, cost is low.
Description
Technical field
The present invention relates to a kind of micropill using tartaric acid as main component, belong to medicine food technical field.
Background technology
Tartaric acid (tartaricacid), that is, 2,3 dihydroxybutanedioic acid is a kind of carboxylic acid, is present in various plants, is also one of organic acid main in wine.As the antioxidant added in food, food can be made to have tart flavour.The maximum purposes of tartaric acid is beverage additive, is also the raw material of pharmaceutical preparation.At the medicine of some stable under acidic conditions, tartaric acid can become preparation with these drug regimens, makes its drug substance stable, promotes that it discharges simultaneously, makes it play maximum drug effect.But at present, tartaric acid is made the medicine carrying ball heart, and as base ball, still see there is bibliographical information at home and abroad, more without there being product to come out.
Summary of the invention
The object of the present invention is to provide a kind of micropill using tartaric acid as main component, for sustained-release preparation supplies a model, make pill.This micropill is easily molding not only, can give full play to the original character of tartaric acid, meanwhile, can also alleviate the stimulation of tartaric acid dust to contact personnel, and guarantee the result of use of tartaric acid micropill.
For achieving the above object, the present invention takes following technical measures:
A kind of micropill using tartaric acid as main component of the present invention, select content more than 98% tartaric acid as primary raw material, add microcrystalline Cellulose, polyvidone class as binding agent, add starch as diluent, add foaming agent simultaneously, be made into micropill by centrifugal granulating technique.Its composition weight proportioning is (%):
Polyvidone class binding agent of the present invention is PVP K30 or hydroxypropyl emthylcellulose or hydroxypropyl cellulose or carboxymethyl cellulose sodium or methylcellulose.
Foaming agent of the present invention is that citric acid adds sodium bicarbonate, its effect be produce foaming so that tartaric acid micropill be celphere medicine-feeding after dispersion and medicine stripping release.
According to a kind of micropill using tartaric acid as main component that above-mentioned formula is made, not only easily molding, but also fully maintain the original character of tartaric acid and the feature facilitating medicine carrying, the various gastric solubilities adopting this micropill to make, enteric solubility pill, not only there is the advantage that drug release reproducibility is good, and there is the features such as easy to prepare, cost is low.
Detailed description of the invention
By the following examples the present invention is further described, embodiment is only for the object of illustration, do not limit the scope of the invention, meanwhile, the apparent change that those of ordinary skill in the art make according to the present invention and modification are also contained within scope of the present invention.
Embodiment 1
According to the composition weight proportioning using tartaric acid as the micropill of main component, get tartaric acid: 420g (35%), microcrystalline cellulose: 300g (25%), starch: 180g (15%), citric acid: 120g (10%), sodium bicarbonate: 120g (10%), PVP K30: 60g (5%).
PVP K30 is dissolved in 95% ethanol, secondly after tartaric acid, microcrystalline Cellulose, starch, citric acid, sodium bicarbonate fully being mixed, the centrifugal granulator spheronizator being placed in operation is prepared, the operating parameter of centrifugal granulator spheronizator, to be the scope of normalized air supply be its intake: 0.9-1.1 (m
3/ h)/kg, the rotating speed 160-180rpm of spheronizator centrifugal granulating, spray gun rotating speed 40-50rpm, flow-control, at 50-80rpm, can be prepared into the micropill of 0.2-1.2mm like this.
Embodiment 2
According to the composition weight proportioning using tartaric acid as the micropill of main component, get tartaric acid: 600g (50%), microcrystalline cellulose: 240g (20%), starch: 120g (10%), citric acid: 120g (10%), sodium bicarbonate: 60g (5%), PVP K30: 60g (5%).
PVP K30 is dissolved in 95% ethanol, secondly after tartaric acid, microcrystalline Cellulose, starch, citric acid, sodium bicarbonate fully being mixed, the centrifugal granulator spheronizator being placed in operation is prepared, the operating parameter of centrifugal granulator spheronizator, to be the scope of normalized air supply be its intake: 0.9-1.1 (m
3/ h)/kg, the rotating speed 160-180rpm of spheronizator centrifugal granulating, spray gun rotating speed 40-50rpm, flow-control, at 50-80rpm, can be prepared into the micropill of 0.2-1.2mm like this.
Embodiment 3
According to the composition weight proportioning using tartaric acid as the micropill of main component, get tartaric acid: 300g (37.5%), microcrystalline cellulose: 150g (18.75%), starch: 150g (18.75%), citric acid: 70g (8.75%), sodium bicarbonate: 70g (8.75%), PVP K30: 60g (7.5%).
PVP K30 is dissolved in 95% ethanol, secondly after tartaric acid, microcrystalline Cellulose, starch, citric acid, sodium bicarbonate fully being mixed, the centrifugal granulator spheronizator being placed in operation is prepared, the operating parameter of centrifugal granulator spheronizator, to be the scope of normalized air supply be its intake: 0.9-1.1 (m
3/ h)/kg, the rotating speed 160-180rpm of spheronizator centrifugal granulating, spray gun rotating speed 40-50rpm, flow-control, at 50-80rpm, can be prepared into the micropill of 0.2-1.2mm like this.
Claims (2)
1. one kind using tartaric acid as the micropill of main component, select content more than 98% tartaric acid as primary raw material, add microcrystalline Cellulose, polyvidone class as binding agent, add starch as diluent, add foaming agent simultaneously, be made into micropill by centrifugal granulating technique, its composition weight proportioning is %:
Described foaming agent is that citric acid adds sodium bicarbonate.
2. a kind of micropill using tartaric acid as main component according to claim 1, is characterized in that described polyvidone class binding agent is PVP K30 or hydroxypropyl emthylcellulose or hydroxypropyl cellulose or carboxymethyl cellulose sodium or methylcellulose.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310361565.8A CN103417494B (en) | 2013-08-13 | 2013-08-13 | A kind of micropill using tartaric acid as main component |
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| CN201310361565.8A CN103417494B (en) | 2013-08-13 | 2013-08-13 | A kind of micropill using tartaric acid as main component |
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| Publication Number | Publication Date |
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| CN103417494A CN103417494A (en) | 2013-12-04 |
| CN103417494B true CN103417494B (en) | 2015-12-23 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105663073A (en) * | 2016-04-06 | 2016-06-15 | 刘建军 | Method for preparing traditional Chinese medicine tablet granulated by adhesive foam state |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166361A (en) * | 2011-04-19 | 2011-08-31 | 杭州高成生物营养技术有限公司 | Quick-collapsed type pellet core and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2303314T3 (en) * | 2006-02-09 | 2008-08-01 | Teva Pharmaceutical Industries Ltd. | PROLONGED RELEASE FORMULATIONS OF DIPIRIDAMOL AND PROCEDURE FOR PREPARATION. |
| NZ586870A (en) * | 2007-12-28 | 2012-10-26 | Impax Laboratories Inc | Controlled release formulations of levodopa, carbidopa andd a caboxylic acid |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166361A (en) * | 2011-04-19 | 2011-08-31 | 杭州高成生物营养技术有限公司 | Quick-collapsed type pellet core and preparation method thereof |
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