CN103396452A - 一种核黄素磷酸钠化合物及其组合物 - Google Patents
一种核黄素磷酸钠化合物及其组合物 Download PDFInfo
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- CN103396452A CN103396452A CN2013103621057A CN201310362105A CN103396452A CN 103396452 A CN103396452 A CN 103396452A CN 2013103621057 A CN2013103621057 A CN 2013103621057A CN 201310362105 A CN201310362105 A CN 201310362105A CN 103396452 A CN103396452 A CN 103396452A
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- sodium phosphate
- riboflavin
- degrees
- riboflavin sodium
- composition
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Abstract
Description
| 1个月 | 2个月 | 3个月 | 6个月 | 12个月 | |
| 1 | 99.96% | 99.93% | 99.88% | 99.55% | 98.58% |
| 2 | 99.92% | 99.90% | 99.82% | 99.45% | 98.50% |
| 3 | 99.88% | 99.85% | 99.72% | 99.32% | 98.32% |
| 4 | 99.92% | 99.88% | 99.71% | 99.30% | 97.28% |
| 5 | 99.95% | 99.92% | 99.82% | 99.24% | 97.89% |
| 3个月 | 6个月 | 9个月 | 12个月 | 18个月 | |
| 1 | 99.95% | 99.93% | 99.90% | 99.64% | 99.25% |
| 2 | 99.91% | 99.89% | 99.84% | 99.55% | 98.81% |
| 3 | 99.87% | 99.84% | 99.76% | 99.45% | 98.66% |
| 4 | 99.94% | 99.90% | 99.75% | 99.46% | 98.10% |
| 5 | 99.96% | 99.92% | 99.85% | 99.42% | 98.27% |
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310362105.7A CN103396452B (zh) | 2013-08-19 | 2013-08-19 | 一种核黄素磷酸钠化合物及其组合物 |
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| CN201310362105.7A CN103396452B (zh) | 2013-08-19 | 2013-08-19 | 一种核黄素磷酸钠化合物及其组合物 |
Publications (2)
| Publication Number | Publication Date |
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| CN103396452A true CN103396452A (zh) | 2013-11-20 |
| CN103396452B CN103396452B (zh) | 2015-09-30 |
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| CN201310362105.7A Active CN103396452B (zh) | 2013-08-19 | 2013-08-19 | 一种核黄素磷酸钠化合物及其组合物 |
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| CN (1) | CN103396452B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114702524A (zh) * | 2022-04-29 | 2022-07-05 | 湖北广济药业股份有限公司 | 一种制备高纯度核黄素磷酸钠的方法 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU166356A1 (ru) * | 1961-12-15 | 1964-11-19 | Способ получения рибофлавип-5'-фосфата натрия | |
| US4987229A (en) * | 1988-03-31 | 1991-01-22 | Basf Aktiengesellschaft | Purification of salts of riboflavin 5'-phosphate, in particular of monosodium riboflavin 5'-phosphate |
| US5017700A (en) * | 1988-10-19 | 1991-05-21 | Basf Aktiengesellschaft | Preparation of riboflavin-5'-phosphate (5'-FMN) and its sodium salt, and of riboflavin-4',5'-cyclophosphoric acid ester chloride as an intermediate |
| US5095115A (en) * | 1989-09-14 | 1992-03-10 | Basf Aktiengesellschaft | Preparation of riboflavin 5'-phosphate (fmn) and its sodium salt in a lactone |
| EP0523582A1 (de) * | 1991-07-19 | 1993-01-20 | BASF Aktiengesellschaft | Verbessertes Verfahren zur Herstellung des Mononatriumsalzes von Riboflavin 5'-phosphat |
| JPH1149790A (ja) * | 1997-06-05 | 1999-02-23 | Eisai Co Ltd | リボフラビン−５’−リン酸またはそのナトリウム塩の製造法 |
| WO2003010172A1 (en) * | 2001-07-23 | 2003-02-06 | Eisai Co., Ltd. | Process for producing highly pure riboflavin-5’-phosphate sodium |
| CN102206233A (zh) * | 2011-04-06 | 2011-10-05 | 湖北广济药业股份有限公司 | 核黄素磷酸酯钠的工业化制备方法 |
-
2013
- 2013-08-19 CN CN201310362105.7A patent/CN103396452B/zh active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU166356A1 (ru) * | 1961-12-15 | 1964-11-19 | Способ получения рибофлавип-5'-фосфата натрия | |
| US4987229A (en) * | 1988-03-31 | 1991-01-22 | Basf Aktiengesellschaft | Purification of salts of riboflavin 5'-phosphate, in particular of monosodium riboflavin 5'-phosphate |
| US5017700A (en) * | 1988-10-19 | 1991-05-21 | Basf Aktiengesellschaft | Preparation of riboflavin-5'-phosphate (5'-FMN) and its sodium salt, and of riboflavin-4',5'-cyclophosphoric acid ester chloride as an intermediate |
| US5095115A (en) * | 1989-09-14 | 1992-03-10 | Basf Aktiengesellschaft | Preparation of riboflavin 5'-phosphate (fmn) and its sodium salt in a lactone |
| EP0523582A1 (de) * | 1991-07-19 | 1993-01-20 | BASF Aktiengesellschaft | Verbessertes Verfahren zur Herstellung des Mononatriumsalzes von Riboflavin 5'-phosphat |
| JPH1149790A (ja) * | 1997-06-05 | 1999-02-23 | Eisai Co Ltd | リボフラビン−５’−リン酸またはそのナトリウム塩の製造法 |
| WO2003010172A1 (en) * | 2001-07-23 | 2003-02-06 | Eisai Co., Ltd. | Process for producing highly pure riboflavin-5’-phosphate sodium |
| CN102206233A (zh) * | 2011-04-06 | 2011-10-05 | 湖北广济药业股份有限公司 | 核黄素磷酸酯钠的工业化制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 孙文敬等: "核黄素磷酸钠生产工艺的研究", 《食品科学》, vol. 29, no. 8, 31 December 2008 (2008-12-31), pages 188 - 190 * |
| 魏转等: "利用核黄素粗品制备核黄素5"-磷酸钠", 《中国食品添加剂》, no. 6, 31 December 2011 (2011-12-31), pages 49 - 55 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114702524A (zh) * | 2022-04-29 | 2022-07-05 | 湖北广济药业股份有限公司 | 一种制备高纯度核黄素磷酸钠的方法 |
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| Publication number | Publication date |
|---|---|
| CN103396452B (zh) | 2015-09-30 |
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Effective date of registration: 20170925 Address after: 330002, No. 26, building E1, building 52, Chinese medicine city, Zhangshu City, Jiangxi, Yichun Patentee after: Zhangshu pure Consulting Service Center Address before: 330002 H, Pearl Plaza, Jiefang West Road, Jiangxi, Nanchang 1709, China Patentee before: Zhou Xiaodong |
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Effective date of registration: 20180206 Address after: 330002, No. 26, building E1, building 52, Chinese medicine city, Zhangshu City, Jiangxi, Yichun Co-patentee after: Dexing Hongrui Labor Service Co., Ltd. Patentee after: Zhangshu pure Consulting Service Center Co-patentee after: Yushan fine fine biological science and Technology Service Center Co-patentee after: Yushan County Yaai fragrant medical consultation center Address before: 330002, No. 26, building E1, building 52, Chinese medicine city, Zhangshu City, Jiangxi, Yichun Patentee before: Zhangshu pure Consulting Service Center |
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Effective date of registration: 20191111 Address after: 334000 no.076, Meiwu Town, xibian village, Chaoyang Town, Xinzhou period, Shangrao City, Jiangxi Province Co-patentee after: Shangrao City Baishi Information Technology Service Center Patentee after: Shangrao mayor pre Information Technology Service Center Co-patentee after: Dexing Xiangwei information consulting service department Co-patentee after: Shaanxi leyingying Enterprise Management Consulting Co., Ltd Co-patentee after: Gao'an Taiji Labor Service Co., Ltd Co-patentee after: Dexing Zhifa information consulting service department Co-patentee after: Dexing Guihou information consulting service department Co-patentee after: Xi'an shuhanhu Enterprise Management Consulting Co., Ltd Co-patentee after: Fuyang Taipan Pharmaceutical Technology Co., Ltd Co-patentee after: Dexing harmonious business service center Address before: No. 52, building No. 26, E1, Chinese medicine city, Zhangshu City, Yichun, Jiangxi Co-patentee before: Dexing Hongrui Labor Service Co., Ltd. Patentee before: Zhangshu pure Consulting Service Center Co-patentee before: Yushan fine fine biological science and Technology Service Center Co-patentee before: Yushan County Yaai fragrant medical consultation center |