CN103393927A - Medicine for treating climacteric syndrome and preparation method thereof - Google Patents
Medicine for treating climacteric syndrome and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating climacteric syndrome and a preparation method thereof. The medicine mainly comprises golden cypress, rhizoma anemarrhenae, rhizoma alismatis, poria, glossy privet fruit, radix ophiopogonis, schisandra chinensis and angelica sinensis according to a certain weight ratio. The medicine disclosed by the invention has the functions of nourishing yin and moistening the lung, clearing away the heart fire and relieving restlessness, enriching and adjusting blood, regulating menstruation and relieving pain, and nourishing yin to lessen fire, and has the advantages of rapid and good curative effect and favorable curative rate when being used for treating climacteric syndrome.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of climacteric syndrome and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Climacteric refers to the one section period of women from period of duration to the geratic period transition, is the period that ovarian function fails gradually.Start from 40 years old, last 10-20, menopause is important symbol.During this period,, because the sex hormones secretion amount reduces, occur claiming climacteric syndrome take autonomic nervous dysfunction as main syndrome.It is high that primary disease makes ovarian function lose the rapid person's sickness rate of decrease in estrogen at malnutrition, spiritual emotional instability and operation, radiotherapy, and symptom is also more serious.Because Western medicine can't effectively be treated climacteric syndrome, and the long-term taking Western medicine has more side effect, and therefore, there is very large demand in people to the Chinese medicine of rapid, effective treatment climacteric syndrome.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical repeatedly test and checking, has finally found the medicine of effective treatment climacteric syndrome, thereby has completed the present invention.
Purpose of the present invention just is to provide a kind of composition of medicine that can effectively treat climacteric syndrome.
Another object of the present invention just has been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Cortex Phellodendri, the Rhizoma Anemarrhenae, Rhizoma Alismatis, Poria, Fructus Ligustri Lucidi, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, Radix Morindae Officinalis, Radix Arnebiae (Radix Lithospermi), the Radix Paeoniae Alba, Herba Epimedii, Semen Cuscutae, Radix Astragali medicine to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of climacteric syndrome.Wherein select Cortex Phellodendri to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select the Rhizoma Anemarrhenae to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, diuretic is arranged, eliminating dampness by diuresis, the function that expels the heat-evil, control dysuria, and the edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria, the edema distension, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting, have loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Fructus Ligustri Lucidi to be because its property bitter but sweet flavor is flat, enter liver, kidney channel, invigorating the liver and kidney is arranged, the function of strong waist knee joint, control yin asthenia generating intrinsic heat, dizziness, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Select be Radix Ophiopogonis because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, nourishing YIN and moistening the lung is arranged, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid, control dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation, clear thirsty, calentura Tianjin wound, dry mouth and throat, constipation.Select Fructus Schisandrae Chinensis to be because its nature and flavor are sour, temperature, enter lung, kidney channel, astringes the lung, and nourishing kidney, promote the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission, control the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Selecting Radix Morindae Officinalis is that temperature, enter liver, kidney channel, and kidney-replenishing is arranged because of its property acrid-sweet flavor, strengthening bone and muscle, and the function of wind-damp dispelling, control sexual impotence, few abdomen cold type of pain, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, soreness of waist and knee joint.Select Radix Arnebiae (Radix Lithospermi) to be because its nature and flavor earnestly, cold, enter percardium, Liver Channel, removing heat from blood is arranged, invigorate blood circulation, the function of heat-clearing and toxic substances removing, control warm macule, jaundice due to damp-heat, purpura, tell, nosebleed, hematuria, stranguria with turbid discharge, dysentery, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, nourishing blood to suppress the hyperactive liver is arranged, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Selecting Herba Epimedii is that temperature, enter liver, kidney channel, and kidney invigorating and YANG supporting is arranged because of its property acrid-sweet flavor, and the function of expelling wind and removing dampness is controlled the sexual impotence erectile problem, dribbling urination, and the muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Select Semen Cuscutae to be because its property acrid-sweet flavor is flat, enter liver, kidney channel, invigorating the liver and kidney is arranged, beneficial marrow, the function of improving eyesight, control soreness of waist and knee joint, and seminal emission, quench one's thirst, dripping urination, order is dark.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enter lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting, control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and hold back for a long time; Process with the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.
The specific embodiment
The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope
Cortex Phellodendri 8-15 gram Rhizoma Anemarrhenae 8-15 gram Rhizoma Alismatis 10-20 grams
Poria 10-20 gram Fructus Ligustri Lucidi 10-20 gram grams Radix Ophiopogonis 10-20
Fructus Schisandrae Chinensis 10-20 gram Radix Angelicae Sinensis 8-15 gram Radix Morindae Officinalis 8-15 grams
Radix Arnebiae (Radix Lithospermi) 10-20 gram Radix Paeoniae Alba 15-25 gram Herba Epimedii 8-15 grams
Semen Cuscutae 15-25 gram Radix Astragali 8-15 grams
Preferable amount is
The Cortex Phellodendri 10 gram Rhizoma Anemarrhenae 10 gram Rhizoma Alismatis 15 grams
Poria 15 gram Fructus Ligustri Lucidi 15 gram grams Radix Ophiopogonis 15
Fructus Schisandrae Chinensis 15 gram Radix Angelicae Sinensis 10 gram Radix Morindae Officinalis 10 grams
The Radix Arnebiae (Radix Lithospermi) 15 gram Radix Paeoniae Alba 20 gram Herba Epimedii 10 grams
The Semen Cuscutae 20 gram Radix Astragali 10 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding, dry;
2, the Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, moistens softly, and section is dried;
3, Rhizoma Alismatis: choose decontamination, big or small stepping, be soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dry;
4, Poria: be soaked in water, clean, pull out, vexed after, cut into slices, dry;
5, Fructus Ligustri Lucidi: choose decontamination, clean, dry;
6, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, then clean and dry;
7, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
8, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;
9, Radix Morindae Officinalis: choose decontamination, after soaking with hot water, take out while hot core, cutting, dry;
10, Radix Arnebiae (Radix Lithospermi): clean, run through, section, dry;
11, the Radix Paeoniae Alba: choose decontamination, size separately, be soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
12, Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;
13, Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;
14, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry.
Two, preparation
1, the Cortex Phellodendri of described weight, the Rhizoma Anemarrhenae, Rhizoma Alismatis, Poria, Fructus Ligustri Lucidi, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, Radix Morindae Officinalis, Radix Arnebiae (Radix Lithospermi), the Radix Paeoniae Alba, Herba Epimedii, Semen Cuscutae, the Radix Astragali are decocted with water secondary, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, used again slow fire boiling 20 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time.
2, the medicinal residues after filtering for the first time add 4 times of amounts of water, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filter to obtain decoction liquor for the second time.
3, twice decoction liquor merged, intense fire boils, then uses slow fire boiling 10 minutes, decoction liquor is divided into 4 doses takes.
Medicine of the present invention has nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, and benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the effect of nourishing YIN to lower pathogenic fire, treatment climacteric syndrome instant effect, short treating period, do not recur.
Below further set forth the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 20ml/kg, and administering mode is the administration by gavage administration, every day 2 times, serve on 7 days, observe the administration reaction every day, result shows that two groups of rabbit are movable, diet is normal, medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's 300 examples for medical treatment.
2, diagnostic criteria
Clinical manifestation
(1) menoxenia: menstrual cycle extends, and through amount, reduces gradually; Or the menstrual cycle shortening, menorrhagia; Or cycle, menstrual period, through amount, do not plan; Or menolipsis suddenly.
(2) paroxysmal hectic fever, perspiration, companioned with headache, dizziness, cardiopalmus, uncomfortable in chest, nauseating etc.
(3) absent-minded, emotional, have a sleepless night, worry too much, the Spirit nerve symptoms of disease such as depressed.
(4) genitals's atrophy in various degree.
(5) mastoptosis, atrophy, frequent micturition, urinary incontinence etc.
(6) osteoporosis, lumbago and backache, easy fracture.
3, Therapeutic Method
Select above-mentioned medicament, to the patient, take, each serving with 1 dose, every day early, respectively take 1 evening, and 15 days is a course for the treatment of, takes continuously 4 courses for the treatment of.
4, efficacy assessment standard
Produce effects: climacteric syndrome is eliminated, and observes after half a year without recurrence;
Take a turn for the better: the climacteric syndrome symptom is clearly better;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, with Drug therapy climacteric syndrome Patients with 300 Cases of the present invention, produce effects 290 examples as a result, obvious effective rate is 96.67%, 6 examples that take a turn for the better, improvement rate is 2%, invalid 4 examples, total effective rate is 98%.
Claims (3)
1. medicine for the treatment of climacteric syndrome, it is characterized in that: it is to be made by the crude drug in following weight range:
Cortex Phellodendri 8-15 gram Rhizoma Anemarrhenae 8-15 gram Rhizoma Alismatis 10-20 grams
Poria 10-20 gram Fructus Ligustri Lucidi 10-20 gram grams Radix Ophiopogonis 10-20
Fructus Schisandrae Chinensis 10-20 gram Radix Angelicae Sinensis 8-15 gram Radix Morindae Officinalis 8-15 grams
Radix Arnebiae (Radix Lithospermi) 10-20 gram Radix Paeoniae Alba 15-25 gram Herba Epimedii 8-15 grams
Semen Cuscutae 15-25 gram Radix Astragali 8-15 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
The Cortex Phellodendri 10 gram Rhizoma Anemarrhenae 10 gram Rhizoma Alismatis 15 grams
Poria 15 gram Fructus Ligustri Lucidi 15 gram grams Radix Ophiopogonis 15
Fructus Schisandrae Chinensis 15 gram Radix Angelicae Sinensis 10 gram Radix Morindae Officinalis 10 grams
The Radix Arnebiae (Radix Lithospermi) 15 gram Radix Paeoniae Alba 20 gram Herba Epimedii 10 grams
The Semen Cuscutae 20 gram Radix Astragali 10 grams.
3. the preparation method of described medicine according to claim 1 and 2, it comprises the following steps:
(1) get the raw materials ready
(1) Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding, dry;
(2) Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, moistens softly, and section is dried;
(3) Rhizoma Alismatis: choose decontamination, big or small stepping, be soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dry;
(4) Poria: be soaked in water, clean, pull out, vexed after, cut into slices, dry;
(5) Fructus Ligustri Lucidi: choose decontamination, clean, dry;
(6) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, then clean and dry;
(7) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
(8) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;
(9) Radix Morindae Officinalis: choose decontamination, after soaking with hot water, take out while hot core, cutting, dry;
(10) Radix Arnebiae (Radix Lithospermi): clean, run through, section, dry;
(11) Radix Paeoniae Alba: choose decontamination, size separately, be soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
(12) Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;
(13) Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;
(14) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(2) preparation
(1) Cortex Phellodendri of described weight, the Rhizoma Anemarrhenae, Rhizoma Alismatis, Poria, Fructus Ligustri Lucidi, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, Radix Morindae Officinalis, Radix Arnebiae (Radix Lithospermi), the Radix Paeoniae Alba, Herba Epimedii, Semen Cuscutae, the Radix Astragali are decocted with water secondary, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, used again slow fire boiling 20 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time;
(2) medicinal residues after filtering for the first time add 4 times of amounts of water, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filter to obtain decoction liquor for the second time;
(3) twice decoction liquor merged, intense fire boils, then uses slow fire boiling 10 minutes, decoction liquor is divided into 4 doses takes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815207A (en) * | 2015-04-29 | 2015-08-05 | 广西大学 | Pharmaceutical composition for treating climacteric syndrome |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184659A (en) * | 1997-11-14 | 1998-06-17 | 张锡昆 | Traditional Chinese medicine for tonifying kidney and strengthening spleen and stomach |
| CN1735421A (en) * | 2002-12-04 | 2006-02-15 | 余仁生(香港)有限公司 | A kind of medicine for treating climacteric syndrome of women and preparation method thereof |
| CN1876096A (en) * | 2006-04-21 | 2006-12-13 | 韩志强 | Main component of Chinese medicinal capsule for treating climacteric syndrome and preparation method thereof |
| CN102406834A (en) * | 2011-12-05 | 2012-04-11 | 哈尔滨济博生物技术开发有限公司 | Medicine for treating yang deficiency type climacteric syndrome of women |
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2013
- 2013-07-26 CN CN201310318296.7A patent/CN103393927B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184659A (en) * | 1997-11-14 | 1998-06-17 | 张锡昆 | Traditional Chinese medicine for tonifying kidney and strengthening spleen and stomach |
| CN1735421A (en) * | 2002-12-04 | 2006-02-15 | 余仁生(香港)有限公司 | A kind of medicine for treating climacteric syndrome of women and preparation method thereof |
| CN1876096A (en) * | 2006-04-21 | 2006-12-13 | 韩志强 | Main component of Chinese medicinal capsule for treating climacteric syndrome and preparation method thereof |
| CN102406834A (en) * | 2011-12-05 | 2012-04-11 | 哈尔滨济博生物技术开发有限公司 | Medicine for treating yang deficiency type climacteric syndrome of women |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815207A (en) * | 2015-04-29 | 2015-08-05 | 广西大学 | Pharmaceutical composition for treating climacteric syndrome |
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