CN103393576B - A kind of mangosteen extract and application thereof - Google Patents
A kind of mangosteen extract and application thereof Download PDFInfo
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- CN103393576B CN103393576B CN201310340403.6A CN201310340403A CN103393576B CN 103393576 B CN103393576 B CN 103393576B CN 201310340403 A CN201310340403 A CN 201310340403A CN 103393576 B CN103393576 B CN 103393576B
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- mangosteen
- extract
- mangosteen extract
- ethanol
- solution
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a kind of mangosteen extract and application thereof, described mangosteen extract has good whitening and antidotal effect, can be used for cosmetics, health food and field of medicaments, especially can be applicable in cosmetics.
Description
Technical field
The invention belongs to field of natural product chemistry, particularly relate to a kind of mangosteen extract and application thereof.
Background technology
Garcinia mangostana (Garciniamangostana) is a kind of fruit originating in tropical and subtropical zone, has very high nutritive value, has another name called mangosteen, Manggis, Cortex Garciniae, originates in torrid areas, Nan Yang, has the title of " after the fruit of the torrid zone ".The areas such as Taiwan of China, Guangdong, Fujian and Yunnan also more introduces a fine variety, and people are called " after in fruit " and " God really ".Why Garcinia mangostana is called " torrid zone fruit after ", and except itself has a sweet taste, another main cause is the role taken in the medicine of ancient times Southeast Asia, and traditionally, Garcinia mangostana is used for controlling the temperature of fever by people and prevents various skin infection.The peel of Garcinia mangostana or crust all contain abundant Xanthone, help enhancement immune system health, and it is happy to make us body and mind.
Garcinia mangostana is nutritious, the sweet middle band acid of taste, delicious abnormal, is rich in flavonoid, polyphenol, protein and lipid.Traditional medicine thinks that its sarcocarp is cold in nature, has refrigerant antipyretic effect, cures mainly thirsty xerostomia, burn, scald, eczema etc.All the time, Garcinia mangostana is in the plant amedica of tropical and subtropical region Chang Zuowei antiinflammatory, and oral administration, also can use in external application, but excessive use can to the toxic effect of mitochondrial function, and infringement Repiration, causes lactic acidosis.
In peel of Carcinia mangostana L., the extraction ratio of volatile oil is 0.14%, identifies 22 kinds of chemical substances, accounts for 92.68% of total composition; In sarcocarp, the extraction ratio of volatile oil is 0.21%, identifies 11 kinds of chemical substances, accounts for 69.11% of total composition.Main containing alkene class, naphthalene class and acids in peel of Carcinia mangostana L. volatile oil, main containing alcohols, alkene class and alkanes in sarcocarp volatile oil; Peel and sarcocarp main constituent are α cadinene, and content is respectively 32.41% and 41.38%.Research shows, mangosteen extract has good antiphlogistic effects, and causing scorching medium to histamine, 5-hydroxy tryptamine and dinoprostone etc. all has good inhibitory action.Simultaneously, mangosteen extract has stronger inhibitory action to the multiple pathogenic microorganism of nature, mangosteen extract can suppress dermatology common disease bacterium as the growth of staphylococcus aureus, some of them composition is still inhibited to methicillin resistant staphylococcus aureus, wherein especially the strongest with α-mangostin activity.But, have not yet to see relevant in Garcinia mangostana in beauty and skin care, the investigation and application of especially whitening aspect.
Summary of the invention
The object of the invention is to: a kind of mangosteen extract and application thereof are provided, be intended to the activity extract in Garcinia mangostana to be applied in skin preparations for extenal use, to play the effect of beauty and skin care.
The object of the present invention is achieved like this:
A kind of mangosteen extract, its infrared spectrum is at 3400cm
-1left and right is the characteristic absorption peak of hydroxyl, 3000-2850cm
-1region is C-H stretching vibration characteristic absorption peak, 1600cm
-1left and right is the characteristic absorption peak of phenyl ring, 1300-1000cm
-1for C-O stretching vibration characteristic absorption peak.
A kind of mangosteen extract, its general flavone content is 1-34%.
By Garcinia mangostana raw material being flooded organic solvent and carrying out after extraction filtering, reducing pressure and concentrated rear acquisition Garcinia mangostana crude extract; By Garcinia mangostana crude extract again through adsorbent resin absorption and the eluting of organic solvent, after evaporate to dryness Garcinia mangostana activity enrichment extract, Garcinia mangostana crude extract and activity enrichment extract are carried out respectively the experimentation of anti-aging effects and whitening function.
Described organic solvent refers to the organic solvent containing hydroxyl or carbonyl isopolarity group, such as but not limited to: water, Methanamide, dimethyl formamide, triethylamine, tri-n-butylamine, acetonitrile, methyl formate, ethyl acetate, DMC dimethyl carbonate, dimethyl sulfoxine, acetone, butanone, dioxane, pyridine, oxolane, methanol, ethanol, acetate fiber, chloroform, glycerol, propylene glycol, propylene glycol, isopropyl alcohol, n-butyl alcohol and ether etc., in one or more, wherein preferred alcohol aqueous solution.
When taking ethanol water as organic solvent, the concentration of ethanol selects 0-95%, and preferably 70%.
Described adsorbent resin and macroporous adsorbent resin, prioritizing selection low pole or the adsorbent resin of middle polarity, such as: X-5, AB-8, D101, XDA-6, LX-21, NK-9, D3520 and WLD etc., wherein preferred AB-8 resin, AB-8 is polystyrene type nonpolar adsorption resin, there is certain ester group on surface, is hydrophobic adsorption.The specific surface area of this resin and aperture are comparatively large, are suitable for that absorption is all kinds of has certain hydrophobic composition, and adsorbance is comparatively large, and eluting is easy, and adsorption dynamics adsorption kinetics is functional.Stablize the acid under heat, organic solvent and average operating, alkali, therefore service life is longer.Albumen, saccharide, mineral acid, alkali, salt, micromolecule hydrophilic organics hydrophilicity are not all adsorbed, thus reaches separation object.
Known according to test, mangosteen extract all has good effect in whitening and defying age, can add in cosmetic formulations as active component, and the active component of indication can provide one or more effect in some cases here.
Active component described in the present invention can also be pantothenylol, glycyrrhizic acid dipotassium, allantoin, nicotiamide, NAP, Herba Violae Hortensis extract, hyaluronate sodium, tocopherol acetas, undecylenoyl phenylalanine etc.In addition, this type of describes is for the ease of understanding, and is not the application or listed application that composition are limited to specifically note.
Mangosteen extract can be applicable to skin preparations for extenal use, health food and medicine, especially can be applicable in cosmetics, the consumption different according to the dissimilar interpolation of preparation.
Described Dermatologic preparation composition is the general designation concept of all the components being generally used for skin outside, such as, can be cosmetic combination or pharmaceutical compositions.Can be foundation make up material, facial dressing cosmetic preparation, health cosmetic preparation etc. in described cosmetic combination, to its dosage form without particular restriction, can choose reasonable according to different object.
According to the medium difference also allowed containing different cosmeceutical aspects of dosage form and object or matrix excipients in described cosmetic combination.
May be used for the cosmetics of Dermatologic preparation composition of the present invention, dermatological or pharmaceutically acceptable excipient and include, but are not limited to one or more aqueous systems, glycerol, C1-4 alcohols, aliphatic alcohols, fatty ethers, fatty lipid, polyalcohols, di-alcohols, vegetable oil, mineral oil, liposome, lamella lipid material, silicone oil, water or its combination in any.
In the present invention, excipient can be the form of aqueous phase, oil phase, gel, water bag wax pattern emulsion, emulsion oil-in-water or water-in-oil emulsion.Aqueous phase is the mixture of one or more water solublity or dispersibility component, and it can be liquid, semisolid or solid under room temperature (25 DEG C).It can be maybe the form of suspension, dispersion liquid or the solution in water or water-ol excipient that excipient comprises, and it can contain thickening agent or gel.The product form that the knowledge-chosen that those skilled in the art can grasp based on those skilled in the art is suitable, the component wherein comprised.
Described compositions can comprise aqueous phase, this aqueous phase can contain the mixture of water or water and at least one hydrophilic organic solvent, described hydrophilic organic solvent such as alcohol, the straight or branched low-grade monobasic alcohol especially containing 2-5 carbon atom, as ethanol or propanol; Polyhydric alcohol, as propylene glycol, sorbitol, glycerol, pantothenylol or Polyethylene Glycol and composition thereof.
When the compositions of inventing is emulsion form, said composition optionally can also comprise surfactant.
Described compositions can also comprise film forming polymer, as polyurethanes, polyacrylic acid homopolymer or copolymer, polyester, based on the resin of hydrocarbon and/or silicone resin.Polymer can be dissolved in or to be scattered in the acceptable excipient of cosmetics and optional and plasticizer merges.
Compositions of the present invention can also comprise oil phase, and described oil phase to contain under room temperature (25 DEG C) for the oil-soluble of liquid or oil-dispersing property component and/or is at room temperature oily or wax-like material, as wax, semisolid, natural gum and composition thereof.This oil phase can also contain organic solvent.
Usually be at room temperature liquid, suitable oily matter comprises: the oil based on hydrocarbon deriving from animal, as perhydro-squalene; Based on the vegetable oil of hydrocarbon, as the triglyceride of the C4-10 fatty acid of liquid, such as enanthic acid or Trivent OCG class, or oil, such as Oleum helianthi, Semen Maydis oil, soybean oil, Oleum Vitis viniferae, Oleum Ricini, American Avocado Tree oil, caprylic/capric triglyceride class, Jojoba oil; The straight or branched hydro carbons in mineral or synthesis source, such as liquid paraffin and its derivant, vaseline; The esters of synthesizing ester and ethers, particularly fatty alcohol, such as isopropyl myristate, Palmic acid 2-Octyl Nitrite, stearic acid 2-octyldodecyl, isostearyl isostearate ester; Hydroxylating esters, the enanthic acid esters of such as lactic acid isooctadecanol ester, octyl hydroxystearate, octyl hydroxystearate, hydroxy stearic acid octyldodecyl, fatty alcohol, sad esters and capric acid lipid; Polyhydric alcohol esters, such as propylene, neopentyl glycol two heptanoate, the different pelargonate of diethylene glycol two and pentaerythritol esters; Aliphatic alcohols containing C12-26, such as octyldodecanol, 2-butyl capryl alcohol, 2-hexyldecanol, 2-undecylpentadecanol, oleyl alcohol; Based on fluorocarbon oil and/or the fluorosilicon oil of part hydrocarbon, silicone oil, be at room temperature liquid or semisolid volatility or nonvolatile straight chain or cyclo-methicone, such as annular dimethyl polysiloxane and polydimethylsiloxane, it optionally comprises phenyl, such as Silicone DC 556, siloxanes and composition thereof.
Compositions of the present invention can comprise any component be usually used in cosmetic field further.These components comprise antiseptic, water phase thickener (polysaccharide biopolymer, synthetic polymer) and fatty phase thickening agent, aromatic, hydrophilic and lipophilic active agent and composition thereof.
Compositions of the present invention can also comprise other Particle Phase, and described Particle Phase can be the pigment and/or pearling agent and/or filler that use in cosmetic composition.
Pigment may reside in compositions, and suitable inorganic pigment comprises titanium oxide, zirconium oxide and cerium oxide and zinc oxide, ferrum oxide and ferrum are blue; Suitable organic pigment comprises barium, strontium, calcium and aluminum color lake and carbon black.
Pearling agent may reside in compositions, and suitable pearling agent comprises the Muscovitum being coated with titanium oxide, ferrum oxide or natural pigment.
Filler may reside in compositions, suitable filler comprises Pulvis Talci, silicon dioxide, zinc stearate, Muscovitum, Kaolin, nylon powder, polyethylene powders, Teflon, starch, borazon, copolymer microsphere, such as silicone resin microballon.
The oil phase of the present composition can comprise one or more waxes, natural gum or its mixture.Wax comprises based on the wax of hydrocarbon, fluorine wax and/or siloxane wax, and can derive from plant, mineral, animal and/or synthesis source.Suitable wax comprises Cera Flava, Brazil wax, candelilla wax, paraffin, microwax, ceresine; Synthetic wax comprises Tissuemat E, siloxane wax containing C16-45.Natural gum is generally polydimethylsiloxane or sodium carboxymethyl cellulose or polysaccharide, and semi-solid material is generally the compound based on hydrocarbon, as lanoline and derivant thereof.
Compositions of the present invention can be mixed with any suitable product form.This kind of product form includes, but are not limited to aerosol spray, cream, emulsion, solid, liquid, dispersion, foam, gel, astringent, mousse, ointment, powder, patch, brilliantine, solution, hands by pump-type spray, club, facial film and wet paper towel.Can using compositions of the present invention by various method well-known in the art expediently for the preparation of or as cosmetics, dermatological or medicine local application product.
Dermatologic preparation composition of the present invention can comprise one or more following ingredients: anti-allergic agent, antimicrobial, antioxidant, chelating agen, coloring agent depigmentation, emollient, emulsifying agent, exfoliation agent, film former, spice, wetting agent, insect repellent, lubricant, pharmaceutically active agents, humidizer, photostabilizer, antiseptic, skin protectant, skin penetration enhancer, sunscreen, stabilizing agent, surfactant, thickening agent, viscosity modifier, vitamin or its combination in any.
Accompanying drawing explanation
Fig. 1 is the infrared spectrogram of Garcinia mangostana 70% alcohol elution that the embodiment of the present invention provides.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Embodiment 1: the concentration of Extraction solvent (ethanol) is chosen
Get the powder 20g after mangosteen drying and crushing, with pure water 200ml merceration, supersound extraction 2 times under room temperature, each 30min (500W), gets filtrate merging, and decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 30% ethanol 200ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 70% ethanol 200ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 95% ethanol 200ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Above-mentioned 4 kinds of solution prepared are carried out respectively the test of free radical scavenging effect.
Test principle: have single electron according to DPPH free radical, the last one is had to absorb at 517nm place, its alcoholic solution is the characteristic of purple, when there being free radical scavenger to exist, make it absorb owing to matching with its single electron to fade away, its fading extent becomes quantitative relationship with the electron amount of its acceptance, thus can carry out quantitative study fast with spectrophotometer, detect free radical scavenging situation, thus whether judgement sample has oxidation resistance.
Test method: the testing sample solution 2ml of different dilution factor, different ratio is added in test tube, then add 2ml76 μm of ol/LDPPH alcoholic solution, mixing, under room temperature, lucifuge is at dark place reaction 30min.Absorbance A bs is measured at 525nm place.Each concentration in triplicate, is averaged as fitting data, to ensure the accuracy of experimental result.
Clearance rate I (%)=[1-(T-T0)/(C-C0)] × 100%
In formula: T0:2ml water or DMSO add the absorbance of 2mlDPPH solution;
T:2ml sample liquid adds the absorbance of 2mlDPPH solution;
C0:2ml water or DMSO add the absorbance of 2ml95% ethanol;
C:2ml sample liquid adds the absorbance of 2ml95% ethanol.
According to formulae discovery clearance rate above.Result of the test is as shown in table 1:
Table 1
As seen from the above table, when the ethanol of employing 70% volumetric concentration is Extraction solvent, the Free-radical scavenging activity of mangosteen extract is best.
Embodiment 2: choosing of solid-liquid ratio:
Getting the powder 20g after mangosteen drying and crushing, is 70% ethanol 160ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 70% ethanol 200ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 70% ethanol 240ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 70% ethanol 300ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Above-mentioned 4 kinds of solution prepared are carried out respectively the test of free radical scavenging effect, test method is the same.Result of the test is as shown in table 2:
Table 2
As seen from the above table, when the ethanol of employing 70% volumetric concentration is Extraction solvent and solid-liquid ratio is 1: 10, the Free-radical scavenging activity of mangosteen extract is best.
Embodiment 3: the preparation of mangosteen extract
The preparation of Garcinia mangostana crude extract: get the powder 20g after mangosteen drying and crushing is 70% ethanol 200ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, obtains Garcinia mangostana crude extract, for efficacy study.
The preparation of Garcinia mangostana activity enrichment extract: get the powder 100g after mangosteen drying and crushing, with 70% ethanol 1000ml merceration under room temperature, supersound extraction 2 times, each 30min (500W), filtrate merges (about 1800ml), decompression and solvent recovery is extremely without alcohol taste, cross AB-8 resin, successively with 30% ethanol, 50% ethanol and 70% ethanol elution, collect each stream part (respectively about 400ml) respectively, evaporate to dryness, obtain Garcinia mangostana 30% alcohol elution (2.07g) respectively, Garcinia mangostana 50% alcohol elution (1.24g) and Garcinia mangostana 70% alcohol elution (0.53g), for efficacy study.
Embodiment 4: the free radical scavenging Effect study of mangosteen extract
The crude extract of the Garcinia mangostana of preparation, 30% alcohol elution, 50% alcohol elution and 70% alcohol elution are carried out respectively the test of free radical scavenging effect, test method is the same.Result of the test is as shown in table 3:
Table 3
As seen from the above table, the various extracts of Garcinia mangostana all have the effect of good scavenging free radicals to free radical, and especially the scavenging action of 70% alcohol elution to free radical is best.
Embodiment 5: the Elastase Inhibitory research of mangosteen extract
Test method is according to document (Am.J.Pharmacol.Toxicol., 2009,4, method 127-129) is carried out, step is: in 96 orifice plates, add the 0.1MTris-Cl buffer solution (PH=8.0) that 10uL sample solution and 130uL contain 1.015mM reaction substrate Succ-Ala-Ala-Ala-p-nitroanilide, incubation 5 minutes at 25 DEG C, add 15uL elastin laminin enzymatic solution (0.5U/ml), continue incubation 30min at 25 DEG C, then measure the absorbance of 410nm wavelength by microplate reader.Replace sample aqueous solution with deionized water, as reference solution, measure absorbance, by with matched group compare the relative inhibition obtaining sample sets.Result of the test is in table 4:
Table 4
As seen from the above table, the various extracts of Garcinia mangostana all have good inhibitory action to elastoser, and especially the inhibitory action of 70% alcohol elution to elastoser is best.
Embodiment 6: the tyrosinase inhibitory action research of mangosteen extract
Test method: the sample solution respectively adding 1ml variable concentrations in sample cell and sample controls pipe, positive and negative control pipe replaces with phosphate buffer.0.5ml tyrosinase solution (Mei Huo unit 125u/ml) is added in sample cell and positive control pipe, sample controls and negative control pipe replace with 0.5ml phosphate buffer (pH=6.8), the all test tubes of jolting, sample and tryrosinase are fully mixed, 37 DEG C of tanks hatch 10 minutes, add the 0.03wt% tyrosine solution of 2ml, react 10 minutes, be namely engraved in 475nm place and measure absorbance.
Suppression ratio I (%)=[1-(T-T0)/(C-C0)] × 100%
In formula: T0: sample solvent contrasts;
T: sample controls;
C: positive control;
C0: positive control solvent control.
Result of the test is as shown in table 5:
Table 5
As seen from the above table, the various extracts of Garcinia mangostana all have good inhibitory action to tryrosinase, and especially the inhibitory action of 70% alcohol elution to tryrosinase is best.
Embodiment 7: the general flavone content of mangosteen extract detects
Pipette sample and rutin contrasts each 1mL in 10mL tool plug test tube, add the aluminum chloride/methanol solution of 1mL1%, by methanol constant volume, shake up, place 15min.With legal system for blank solution.Scan in 200 ~ 500nm wave-length coverage, record ultraviolet-visible absorption spectroscopy.The registration of sample maximum absorption band and rutin maximum absorption band is good, standard substance when therefore selecting rutin to be mensuration.Scanning result is shown in 355nm place and carries out determination of total flavonoids.Testing result is as shown in table 6:
Table 6
| Mangosteen extract | General flavone content (%) |
| Crude extract | 1 |
| 30% alcohol elution | 11 |
| 50% alcohol elution | 9 |
| 70% alcohol elution | 34 |
As seen from the above table, all containing certain total flavones in the various extracts of Garcinia mangostana, the general flavone content wherein in 70% alcohol elution is the highest.
Embodiment 8: the INFRARED ABSORPTION of mangosteen extract detects
Principle: when a branch of infrared light with continuous wavelength passes through material, in material molecule the frequency of vibration of certain group or rotational frequency the same with the frequency of infrared light time, molecule shakes the order transition of (turning) kinetic energy to higher (turning) kinetic energy level of shaking of energy with regard to absorbing energy by original ground state, the transition of vibration and rotational energy level occurs after molecule absorption infra-red radiation, and the light of this place's wavelength is just subsequently absorbed in the material.So infrared spectrometry is in fact a kind of analytical method determining material molecular structure and discriminating compound according to information such as the interatomic Relative Vibration of intramolecule and molecule rotation.The situation instrument record of molecule absorption infrared light is got off, just obtains infrared spectrogram.Infrared spectrogram leads to common wavelengths (λ) or wave number (σ) is abscissa, and representing the position of absworption peak, is vertical coordinate with light transmittance (T%) or absorbance (A), represents absorption intensity.
The infared spectrum of Garcinia mangostana 70% alcohol elution as shown in Figure 1.Known from collection of illustrative plates, the infrared spectrum of this mangosteen extract is at 3400cm
-1left and right is the characteristic absorption peak of hydroxyl, 3000-2850cm
-1region is C-H stretching vibration absworption peak, 1600cm
-1left and right is the characteristic absorption peak of phenyl ring, 1300-1000cm
-1for C-O stretching vibration absworption peak, illustrate that this extract contains phenolic hydroxyl group, phenyl ring etc.
By above various test, visible mangosteen extract has effect of good whitening, anti-ageing beauty and skin care of waiting for a long time.
Embodiment 9: the skin preparations for extenal use containing mangosteen extract
Get the powder 500g after mangosteen drying and crushing, with 70% ethanol 5000ml merceration, supersound extraction 2 times under room temperature, each 30min (500W), filtrate merges, decompression and solvent recovery, to without alcohol taste, crosses AB-8 resin, successively with the ethanol elution of variable concentrations, collect each eluting position, for the preparation of skin preparations for extenal use.The percentage by weight of described mangosteen extract in skin preparations for extenal use is 0.0001-4, preferred 0.01-2.It is below the embodiment of the embody rule of mangosteen extract in skin preparations for extenal use.In following table, "-" indicates without interpolation.
Embodiment 10: the astringent containing mangosteen extract
Get mangosteen extract, for the preparation of the astringent with defying age, whitening function, the component that described astringent contains is as shown in table 7:
Table 7
Embodiment 11: the essence containing mangosteen extract
Get mangosteen extract, for the preparation of the essence with defying age, whitening function, the component that described essence contains is as shown in table 8:
Table 8
Embodiment 12: the emulsion/frost containing mangosteen extract
Get mangosteen extract, for the preparation of the emulsion/frost with defying age, whitening function, the component that described emulsion/frost contains is as shown in table 9:
Table 9
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (1)
1. contain mangosteen extract as an essence for effective ingredient, it is characterized in that being made up of by weight percentage following composition:
Acrylic acid (ester) class/C10-30 alkyl acrylate cross-linked polymer PemulenTR-20.3
Aminomethyl propanol adjust ph is to 5.5-7
Essence appropriate amount of deionized water adds to 100
Wherein, mangosteen extract extracts by the following method: get the powder 20g after mangosteen drying and crushing, be 70% ethanol 200ml merceration, 500W supersound extraction 2 times with volumetric concentration under room temperature, each 30min, get filtrate merging, decompression and solvent recovery, to dry, obtains mangosteen extract, the general flavone content of described mangosteen extract is 34%, and the infrared spectrum of described mangosteen extract is at 3400cm
-1for the characteristic absorption peak of hydroxyl, 3000-2850cm
-1region is C-H stretching vibration absworption peak, 1600cm
-1for the characteristic absorption peak of phenyl ring, 1300-1000cm
-1for C-O stretching vibration absworption peak.
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| CN104721119A (en) * | 2015-03-03 | 2015-06-24 | 陈红旗 | Moisturizing hand cream |
| CN106137812A (en) * | 2015-04-03 | 2016-11-23 | 伽蓝（集团）股份有限公司 | Radix Gentianae extract and its production and use |
| CN106361784B (en) * | 2015-07-24 | 2020-08-14 | 山酮新药开发股份有限公司 | Use of mangosteen husk extract for the treatment of skin diseases |
| KR101721917B1 (en) | 2015-09-21 | 2017-03-31 | 경상대학교산학협력단 | - Composition for skin whitening comprising -mangostin as effective component |
| CN105534812A (en) * | 2016-01-19 | 2016-05-04 | 中山百鸥医药科技有限公司 | Essence and preparation method thereof |
| CN105687032B (en) * | 2016-02-03 | 2018-05-11 | 湖南朗林生物制品有限公司 | A kind of natural composition for improving skin health |
| CN107648117A (en) * | 2017-10-31 | 2018-02-02 | 广州赛莱拉干细胞科技股份有限公司 | A kind of whitening spot-removing skin care item and preparation method thereof |
| TWI754345B (en) * | 2019-08-27 | 2022-02-01 | 大江生醫股份有限公司 | Use of garcinia mangostana fermented liquid for preparing a composition for beautifying skin and/or reducing fat |
| CN111357909A (en) * | 2020-04-02 | 2020-07-03 | 吉林农业科技学院 | Purification process and determination experimental method of mangosteen polysaccharide hypoglycemic solid beverage |
| CN111568845A (en) * | 2020-07-02 | 2020-08-25 | 成都恩喜医疗管理有限公司 | Nutrient solution for delaying facial aging |
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