CN103392711A - Thifluzamide composition for preventing and treating rice diseases, and preparation of thifluzamide composition - Google Patents
Thifluzamide composition for preventing and treating rice diseases, and preparation of thifluzamide composition Download PDFInfo
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- CN103392711A CN103392711A CN2013103676897A CN201310367689A CN103392711A CN 103392711 A CN103392711 A CN 103392711A CN 2013103676897 A CN2013103676897 A CN 2013103676897A CN 201310367689 A CN201310367689 A CN 201310367689A CN 103392711 A CN103392711 A CN 103392711A
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- thifluzamide
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- defoamer
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- WOSNCVAPUOFXEH-UHFFFAOYSA-N thifluzamide Chemical compound S1C(C)=NC(C(F)(F)F)=C1C(=O)NC1=C(Br)C=C(OC(F)(F)F)C=C1Br WOSNCVAPUOFXEH-UHFFFAOYSA-N 0.000 title claims abstract description 106
- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 201000010099 disease Diseases 0.000 title claims abstract description 27
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 27
- 235000007164 Oryza sativa Nutrition 0.000 title claims abstract description 26
- 235000009566 rice Nutrition 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims description 8
- 240000007594 Oryza sativa Species 0.000 title 1
- 241000209094 Oryza Species 0.000 claims abstract description 25
- 150000003852 triazoles Chemical class 0.000 claims abstract description 24
- 239000004530 micro-emulsion Substances 0.000 claims abstract description 14
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000000375 suspending agent Substances 0.000 claims abstract description 11
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 8
- 239000003899 bactericide agent Substances 0.000 claims description 21
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 239000013530 defoamer Substances 0.000 claims description 18
- 239000002270 dispersing agent Substances 0.000 claims description 18
- 239000000080 wetting agent Substances 0.000 claims description 18
- 150000003851 azoles Chemical class 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 14
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000005839 Tebuconazole Substances 0.000 claims description 12
- 238000005469 granulation Methods 0.000 claims description 12
- 230000003179 granulation Effects 0.000 claims description 12
- 239000011230 binding agent Substances 0.000 claims description 11
- 239000007884 disintegrant Substances 0.000 claims description 10
- 239000000945 filler Substances 0.000 claims description 10
- 239000003995 emulsifying agent Substances 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- 239000002562 thickening agent Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- FFSJPOPLSWBGQY-UHFFFAOYSA-N triazol-4-one Chemical compound O=C1C=NN=N1 FFSJPOPLSWBGQY-UHFFFAOYSA-N 0.000 claims description 7
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- JWUCHKBSVLQQCO-UHFFFAOYSA-N 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol Chemical compound C=1C=C(F)C=CC=1C(C=1C(=CC=CC=1)F)(O)CN1C=NC=N1 JWUCHKBSVLQQCO-UHFFFAOYSA-N 0.000 claims description 5
- 239000005787 Flutriafol Substances 0.000 claims description 5
- 239000005868 Metconazole Substances 0.000 claims description 5
- 238000000498 ball milling Methods 0.000 claims description 5
- XWPZUHJBOLQNMN-UHFFFAOYSA-N metconazole Chemical compound C1=NC=NN1CC1(O)C(C)(C)CCC1CC1=CC=C(Cl)C=C1 XWPZUHJBOLQNMN-UHFFFAOYSA-N 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 241000894006 Bacteria Species 0.000 claims description 4
- 239000003905 agrochemical Substances 0.000 claims description 4
- 150000001336 alkenes Chemical class 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 4
- 150000002825 nitriles Chemical class 0.000 claims description 4
- 239000005760 Difenoconazole Substances 0.000 claims description 3
- 239000005822 Propiconazole Substances 0.000 claims description 3
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 claims description 3
- STJLVHWMYQXCPB-UHFFFAOYSA-N propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 claims description 3
- 229920006335 epoxy glue Polymers 0.000 claims description 2
- 230000000855 fungicidal effect Effects 0.000 abstract description 5
- 230000001954 sterilising effect Effects 0.000 abstract description 4
- 230000000361 pesticidal effect Effects 0.000 abstract description 2
- 239000000417 fungicide Substances 0.000 abstract 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 18
- 239000000047 product Substances 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 229920001285 xanthan gum Polymers 0.000 description 9
- -1 polysiloxanes Polymers 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 5
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- 239000005995 Aluminium silicate Substances 0.000 description 4
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 150000004996 alkyl benzenes Chemical class 0.000 description 4
- 235000012211 aluminium silicate Nutrition 0.000 description 4
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 4
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 4
- 235000011130 ammonium sulphate Nutrition 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 229940077388 benzenesulfonate Drugs 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
- IXQGCWUGDFDQMF-UHFFFAOYSA-N o-Hydroxyethylbenzene Natural products CCC1=CC=CC=C1O IXQGCWUGDFDQMF-UHFFFAOYSA-N 0.000 description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- SNEYJZBZIICCIN-UHFFFAOYSA-N C1(=CC=CC2=CC=CC=C12)S(=O)(=O)O.C(CCCCCCCCCCC)[Na] Chemical compound C1(=CC=CC2=CC=CC=C12)S(=O)(=O)O.C(CCCCCCCCCCC)[Na] SNEYJZBZIICCIN-UHFFFAOYSA-N 0.000 description 3
- 239000007767 bonding agent Substances 0.000 description 3
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 3
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 2
- HZJKXKUJVSEEFU-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile Chemical compound C=1C=C(Cl)C=CC=1C(CCCC)(C#N)CN1C=NC=N1 HZJKXKUJVSEEFU-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 239000005811 Myclobutanil Substances 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 2
- FBOUIAKEJMZPQG-BLXFFLACSA-N diniconazole-M Chemical compound C1=NC=NN1/C([C@H](O)C(C)(C)C)=C/C1=CC=C(Cl)C=C1Cl FBOUIAKEJMZPQG-BLXFFLACSA-N 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 2
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000001384 succinic acid Substances 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 1
- 241000813090 Rhizoctonia solani Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004546 suspension concentrate Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a thifluzamide composition for preventing and treating rice diseases. The thifluzamide composition comprises thifluzamide, a triazole fungicide and a pesticide-acceptable auxiliary agent combination, wherein a mass ratio of the thifluzamide to the triazole fungicide is (50:1)-(1:50). The invention further provides a method for preparing the thifluzamide composition for preventing and treating the rice diseases. The method comprises the steps of adopting different auxiliary agent combinations, and preparing into a microemulsion, a water dispersible granule or a suspending agent. According to the thifluzamide composition and the method, the thifluzamide and the triazole fungicide are combined for use, and pesticide effects of the thifluzamide and the triazole fungicide are supplemented, so that sterilizing varieties are expanded, and a sterilizing effect is improved; the thifluzamide composition is small in usage amount, environment-friendly and high in preventing and treating ratio, and is particularly applicable to preventing and treating a rice sheath blight disease, rice false smut, rice blast and the like; and the cost of the thifluzamide composition is lower than that of the thifluzamide.
Description
Technical field
The invention belongs to technical field of pesticide, particularly a kind ofly be used to what prevent and treat rice disease, contain thifluzamide composition and preparation thereof.
Background technology
In growth process of riceplant, be vulnerable to Various Diseases insect pest impact, when serious, can cause the significantly underproduction even to be had no harvest.Existing agricultural chemicals is not considered the medicament complementary characteristic, and being mostly makes troubles to dispenser on the one hand for a kind of disease wherein, and another is convenient has also caused waste, and this shortcoming is more obvious when having multiple diseases to exist simultaneously.And existing pesticide sterilizing kind is limited, and bactericidal effect is not good, often needs heavy dose of medication, not only easily causes residual phenomena, also to environment, has brought pollution.The active ingredient of existing agricultural chemicals is single simultaneously, and germ easily produces resistance to it.
Summary of the invention
In order to overcome the shortcoming of above-mentioned prior art, the object of the present invention is to provide and a kind ofly be used to what prevent and treat rice disease, contain thifluzamide composition and preparation thereof, thifluzamide and triazole bactericidal agent are used in combination, and both drug effects are supplemented mutually, when enlarging the sterilization kind, strengthened bactericidal effect, usage amount is little, and is environmentally friendly, and control rate is high, and lower than using separately the thifluzamide cost, be particularly useful for preventing and treating rice sheath blight disease, false smut, rice blast etc.
To achieve these goals, the technical solution used in the present invention is:
A kind ofly be used to what prevent and treat rice disease, contain the thifluzamide composition, comprise thifluzamide and the triazole bactericidal agent of mass ratio 50:1～1:50, and acceptable auxiliary combination on agricultural chemicals.
Described triazole bactericidal agent is a kind of in Difenoconazole, Tebuconazole, own azoles alcohol, triazolone, propiconazole, Flutriafol, metconazole, nitrile bacterium azoles and alkene azoles alcohol.
Described auxiliary agent is emulsifier, antifreezing agent, defoamer and solvent, containing in the thifluzamide composition each composition accounts for mass percent and be: thifluzamide 1～50%, triazole bactericidal agent 1～50%, emulsifier 5～15%, antifreezing agent 0.001～8%, defoamer 0.1～0.5%, surplus are solvent, and this moment, the described thifluzamide composition that contains was microemulsion; Wherein emulsifier can be selected phenethyl phenol polyethenoxy ether (602) or triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer (1601), antifreezing agent can be selected ethylene glycol or glycerine, described defoamer can be selected polysiloxanes or organosilicon, and solvent can be selected dimethylbenzene or methyl alcohol.
The present invention provide simultaneously prepare described be used to preventing and treating the method that contains thifluzamide composition (microemulsion) of rice disease, thifluzamide, triazole bactericidal agent, emulsifier, antifreezing agent, defoamer and solvent are mixed in proportion, the epoxy glue rod evenly, namely can be made into and contains thifluzamide composite microemulsion product in mixed cylinder.
Described auxiliary agent is dispersant, wetting agent, disintegrant, binding agent and filler, containing in the thifluzamide composition each composition accounts for mass percent and be: thifluzamide 1～50%, triazole bactericidal agent 1～50%, dispersant 3～12%, wetting agent 2～8%, disintegrant 0.001～8%, binding agent 0.001～5%, surplus are filler, and this moment, the described thifluzamide composition that contains was water dispersible granules; Wherein said dispersant can be selected dodecyl sodium naphthalene sulfonate (NNO) or sodium methylene bis-naphthalene sulfonate, described wetting agent can be selected lauryl sodium sulfate or dodecyl sodium sulfate, described disintegrant can be selected ammonium sulfate, and described binding agent can be selected xanthans, and described filler can be selected kaolin.
The present invention provide simultaneously prepare described be used to preventing and treating the method that contains thifluzamide composition (water dispersible granules) of rice disease, by thifluzamide, triazole bactericidal agent, dispersant, wetting agent, disintegrant and filler together through air-flow crushing, add again binding agent, obtain the materials of granulating, to granulate with materials quantitative send in the fluidized bed granulation dryer through granulation and drying after, make and contain thifluzamide composition water dispersible granules product.
Described auxiliary agent is dispersant, wetting agent, defoamer, thickener, antifreezing agent and deionized water, containing in the thifluzamide composition each composition accounts for mass percent and is: the deionized water of thifluzamide 1～50%, triazole bactericidal agent 1～50%, dispersant 3～12%, wetting agent 2～10%, defoamer 0.1～0.5%, thickener 0.001～2%, antifreezing agent 0.001～8% and surplus, and this moment, the described thifluzamide composition that contains was suspending agent; Wherein said dispersant can be selected dodecyl sodium naphthalene sulfonate (NNO) or sodium methylene bis-naphthalene sulfonate, described wetting agent can be selected lauryl sodium sulfate or dodecyl sodium sulfate, described defoamer can be selected polysiloxanes or organosilicon, described thickener can be selected xanthans, and described antifreezing agent can be selected ethylene glycol or glycerine.
The present invention provide simultaneously prepare described be used to preventing and treating the method that contains thifluzamide composition (suspending agent) of rice disease, dispersant, wetting agent, defoamer, thickener and antifreezing agent is even through shear-mixed, add again thifluzamide and triazole bactericidal agent mixing and ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make and contain thifluzamide composition suspending agent product.
Compared with prior art, advantage of the present invention is:
One, after thifluzamide and triazole bactericidal agent are mixed, improve bactericidal effect, lowered using dosage;
Two, after thifluzamide and triazole bactericidal agent are mixed, enlarge fungicidal spectrum, the medicament characteristic has obtained mutual supplement with each other's advantages, and a kind of medicament can be prevented and treated the various crop disease, facilitates peasant's medication;
Three,, after thifluzamide and triazole bactericidal agent are mixed, can slow down the generation of resistance, good to crop safety, meet the security requirement of pesticidal preparations.
Embodiment
Below in conjunction with embodiment, describe embodiments of the present invention in detail.
Embodiment 1
50% thifluzamide tebuconazole microemulsion
By mass percent thifluzamide 10%, Tebuconazole 40%, alkylaryl polyoxyethylene poly-oxygen propylene aether 5%, calcium dodecyl benzene sulfonate 5%, ethylene glycol 5%, organosilicon 0.2%, water 34.8%, mixture carries out mix and blend, makes 50% thifluzamide tebuconazole microemulsion.
Embodiment 2
55% thifluzamide triazolone microemulsion
By mass percent thifluzamide 10%, triazolone 45%, emulsifier (phenethyl phenol polyethenoxy ether (602)) 5%, antifreezing agent (ethylene glycol) 0.001%, defoamer (polysiloxanes) 0.1%, surplus is solvent (dimethylbenzene), after mixing, stir, make 55% thifluzamide triazolone microemulsion.
Embodiment 3
30% thifluzamide tebuconazole water dispersible granule
By thifluzamide 5%, Tebuconazole 25%, alkyl benzene sulfonate calcium salt 5%, Nekal BX 6%, succinic acid 3%, starch 20%, precipitated calcium carbonate 35%, together through air-flow crushing, add again citric acid 1%, obtain the materials of granulating, to granulate with materials quantitative send in the fluidized bed granulation dryer through granulation and drying after, make and contain thifluzamide composition water dispersible granules product.
Embodiment 4
35% thifluzamide Flutriafol water dispersible granules
Get thifluzamide 5%, Flutriafol 30%, dispersant (sodium methylene bis-naphthalene sulfonate) 3%, wetting agent (lauryl sodium sulfate) 2%, disintegrant (ammonium sulfate) 0.001%, binding agent (xanthans) 5%, surplus is filler (kaolin), by other material except bonding agent together through air-flow crushing, add again bonding agent, obtain the materials of granulating, to granulate with materials quantitative send in the fluidized bed granulation dryer through granulation and drying after, make and contain thifluzamide composition water dispersible granules product.
Embodiment 5
50% thifluzamide tebuconazole suspension concentrates
Alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 3%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3% mixed at high speed is even, add again thifluzamide 10%, Tebuconazole 40% mixing and ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make and contain thifluzamide composition suspending agent product.
Embodiment 6
55% thifluzamide diniconazole suspending agent
Dispersant 12%, wetting agent 10%, defoamer (organosilicon) 0.5%, thickener (xanthans) 0.001%, antifreezing agent (glycerine) 0.001% and deionized water mixed at high speed is even, add again thifluzamide 15%, alkene azoles alcohol 40% mixing and ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make and contain thifluzamide composition suspending agent product.
Embodiment 7
50% thifluzamide micro-emulsion of phenyl ether methyl cyclic-azole
By mass percent thifluzamide 49%, Difenoconazole 1%, alkylaryl polyoxyethylene poly-oxygen propylene aether 5%, calcium dodecyl benzene sulfonate 5%, ethylene glycol 5%, organosilicon 0.2%, water 34.8%, mixture carries out mix and blend, makes 50% thifluzamide tebuconazole microemulsion.
Embodiment 8
60% thifluzamide myclobutanil micro-emulsion
By mass percent thifluzamide 40%, nitrile bacterium azoles 20%, emulsifier (triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer (1601)) 5%, antifreezing agent (glycerine) 6%, defoamer (polysiloxanes) 0.1%, surplus is solvent (methyl alcohol), mixture carries out mix and blend, makes 60% thifluzamide myclobutanil micro-emulsion.
Embodiment 9
10% thifluzamide diniconazole water dispersible granule
By mass percent thifluzamide 5%, own azoles alcohol 5%, alkyl benzene sulfonate calcium salt 10%, Nekal BX 6%, succinic acid 3%, starch 20%, precipitated calcium carbonate 50%, together through air-flow crushing, add again citric acid 1%, obtain the materials of granulating, to granulate with materials quantitative send in the fluidized bed granulation dryer through granulation and drying after, make and contain thifluzamide composition water dispersible granules product.
Embodiment 10
5% thifluzamide metconazole water dispersible granules
Getting mass percent thifluzamide 4%, metconazole 1%, dispersant (sodium methylene bis-naphthalene sulfonate) 3%, wetting agent (dodecyl sodium sulfate) 2%, disintegrant (ammonium sulfate) 0.001%, binding agent (xanthans) 0.001%, surplus is filler (kaolin), by all the other materials except bonding agent together through air-flow crushing, add again binding agent, obtain the materials of granulating, to granulate with materials quantitative send in the fluidized bed granulation dryer through granulation and drying after, make and contain thifluzamide composition water dispersible granules product.
Embodiment 11
50% thifluzamide triazolone suspending agent
Mass percent alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 4%, DBSA 4%, silicone oil 0.5%, xanthan gum 0.4% and deionized water 37.1% mixed at high speed is even, add again thifluzamide 20%, triazolone 30% mixing and ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make and contain thifluzamide composition suspending agent product.
Embodiment 12-16
With the Tebuconazole in propiconazole, Flutriafol, metconazole, nitrile bacterium azoles, alkene azoles alcohol alternate embodiment 1, make and contain accordingly the thifluzamide composition product respectively.
According to following methods, virulence of the present invention is tested:
Contain the thifluzamide composition and get thifluzamide and the composite product of own azoles alcohol, determination object is rice sheath blight disease, and test environment is indoor, and test medicine provides by the vertical rich biotechnology of Shaanxi Kang He pharmaceutcal corporation, Ltd.
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.With reference to " farm-chemical indoor determination test rule bactericide ", carry out, adopt the pastille medium therapy to measure the virulence of medicament to Rhizoctonia solani Kuhn.After 4 days, measure colony diameter, calculate growth inhibition ratio.Result of the test is as shown in table 1:
Table 1 thifluzamide, own azoles alcohol and the composite analysis of results table of toxicity test to rice sheath blight disease thereof
As shown in Table 1, thifluzamide, the Tebuconazole EC to rice sheath blight disease
50Be respectively 0.031mg/L and 0.237mg/L.The virulence of own azoles alcohol is higher than the virulence of thifluzamide.The co-toxicity coefficient of thifluzamide and own azoles alcohol proportioning 1:1,1:2,1:4,4:1,2:1 is respectively 110.21,124.18,140.60,98.18,103.60, both proportionings show as certain synergistic effect while being 1:1,1:2,1:4, illustrate thifluzamide and own azoles alcohol both in 1:1～1:4 scope, be mixed comparatively reasonable.
In various embodiments of the present invention, dispersant can be selected dodecyl sodium naphthalene sulfonate (NNO) or sodium methylene bis-naphthalene sulfonate, wetting agent can be selected lauryl sodium sulfate or dodecyl sodium sulfate, defoamer can be selected polysiloxanes or organosilicon, thickener can be selected xanthans, and antifreezing agent can be selected ethylene glycol or glycerine, and disintegrant can be selected ammonium sulfate, binding agent can be selected xanthans, and filler can be selected kaolin.
Claims (8)
1. one kind contains the thifluzamide composition be used to what prevent and treat rice disease, it is characterized in that, comprises thifluzamide and the triazole bactericidal agent of mass ratio 50:1～1:50, and acceptable auxiliary combination on agricultural chemicals.
2. according to claim 1ly be used to what prevent and treat rice disease, contain the thifluzamide composition, it is characterized in that, described triazole bactericidal agent is a kind of in Difenoconazole, Tebuconazole, own azoles alcohol, triazolone, propiconazole, Flutriafol, metconazole, nitrile bacterium azoles and alkene azoles alcohol.
3. according to claim 1 and 2ly be used to what prevent and treat rice disease, contain the thifluzamide composition, it is characterized in that, described auxiliary agent is emulsifier, antifreezing agent, defoamer and solvent, containing in the thifluzamide composition each composition accounts for mass percent and is: thifluzamide 1～50%, triazole bactericidal agent 1～50%, emulsifier 5～15%, antifreezing agent 0.001～8%, defoamer 0.1～0.5%, surplus is solvent, and this moment, the described thifluzamide composition that contains was microemulsion.
4. preparation claim 3 is described be used to preventing and treating the method that contains the thifluzamide composition of rice disease, it is characterized in that, thifluzamide, triazole bactericidal agent, emulsifier, antifreezing agent, defoamer and solvent are mixed in proportion, the epoxy glue rod evenly, namely can be made into and contains thifluzamide composite microemulsion product in mixed cylinder.
5. according to claim 1 and 2ly be used to what prevent and treat rice disease, contain the thifluzamide composition, it is characterized in that, described auxiliary agent is dispersant, wetting agent, disintegrant, binding agent and filler, containing in the thifluzamide composition each composition accounts for mass percent and be: thifluzamide 1～50%, triazole bactericidal agent 1～50%, dispersant 3～12%, wetting agent 2～8%, disintegrant 0.001～8%, binding agent 0.001～5%, surplus are filler, and this moment, the described thifluzamide composition that contains was water dispersible granules.
6. preparation claim 5 is described be used to preventing and treating the method that contains the thifluzamide composition of rice disease, it is characterized in that, by thifluzamide, triazole bactericidal agent, dispersant, wetting agent, disintegrant and filler together through air-flow crushing, add again binding agent, obtain the materials of granulating, to granulate with materials quantitative send in the fluidized bed granulation dryer through granulation and drying after, make and contain thifluzamide composition water dispersible granules product.
7. according to claim 1 and 2ly be used to what prevent and treat rice disease, contain the thifluzamide composition, it is characterized in that, described auxiliary agent is dispersant, wetting agent, defoamer, thickener, antifreezing agent and deionized water, containing in the thifluzamide composition each composition accounts for mass percent and be: the deionized water of thifluzamide 1～50%, triazole bactericidal agent 1～50%, dispersant 3～12%, wetting agent 2～10%, defoamer 0.1～0.5%, thickener 0.001～2%, antifreezing agent 0.001～8% and surplus, this moment, the described thifluzamide composition that contains was suspending agent.
8. preparation claim 7 is described be used to preventing and treating the method that contains the thifluzamide composition of rice disease, it is characterized in that, dispersant, wetting agent, defoamer, thickener and antifreezing agent is even through shear-mixed, add again thifluzamide and triazole bactericidal agent mixing and ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make and contain thifluzamide composition suspending agent product.
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| CN106719736A (en) * | 2017-03-07 | 2017-05-31 | 江苏莱科化学有限公司 | A kind of suspending agent of thifluzamide and hexaconazole |
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