CN103385957A - Medicinal preparation for curing calf diarrhea - Google Patents
Medicinal preparation for curing calf diarrhea Download PDFInfo
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- CN103385957A CN103385957A CN2013102926147A CN201310292614A CN103385957A CN 103385957 A CN103385957 A CN 103385957A CN 2013102926147 A CN2013102926147 A CN 2013102926147A CN 201310292614 A CN201310292614 A CN 201310292614A CN 103385957 A CN103385957 A CN 103385957A
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- calf diarrhea
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- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 63
- 244000309466 calf Species 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title abstract description 29
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- 239000000843 powder Substances 0.000 claims abstract description 25
- 241000218176 Corydalis Species 0.000 claims abstract description 22
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- 229930182566 Gentamicin Natural products 0.000 claims abstract description 22
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims abstract description 21
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- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 72
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- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
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- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
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- 229940023964 caffeine and sodium benzoate Drugs 0.000 description 1
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- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a medicinal preparation for curing calf diarrhea and applications thereof, and belongs to the technology field of veterinary medicinal preparation. In order to solve the problems of high cost, bad curative effect and slow effect in the prior art, the invention provides a medicinal preparation for curing calf diarrhea. The compound medicinal preparation is mainly composed of following drugs in parts by weight: 6.0 to 12 parts of gentamycin sulfate (GEN), 15 to 30 parts of rhizoma corydalis, 15 to 20 parts of yeast powder, 15 to 30 parts of alum, 15 to 25 parts of sodium fulvate, 15 to 25 parts of clove, 15 to 30 parts of white pepper, 15 to 30 parts of evodia and 15 to 25 parts of Chinese cassia tree. The compound medicinal preparation has the advantages of low cost, high efficiency on curing calf diarrhea and high cure rate. Furthermore the components are used together to have a synergistic effect, and has the functions of invigorating stomach, regulating Qi, disinfecting, diminishing inflammation, astringing to arrest diarrhea, relieving pains and stopping bleeding.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, belong to veterinary drug preparation technique field.
Background technology
Diarrhoea is a kind of important clinical manifestation and the disease that causes larger proportion death in young stock (dog cat, young coltfoal, calf), can cause huge economic loss to animal husbandry.According to Qinghai Province's statistics, sickness rate can be up to 20% in flock of sheep for diarrhoea, and case fatality rate is more than 90%.According to the statistics in the herding Room, the annual cub death in this zone exceedes more than 1,000,000, and this is a sizable numeral, has caused huge economic loss.
During treatment young stock diarrhoea that the document of the vitamin A of delivering in " Gansu animal and veterinary " in 1987 as people such as Liu Shixi, D auxiliary treatment young stock diarrhoea is mentioned, the conventional method that adopts is as using the medicine anti-inflammations such as sulfanilamide, bismuth subnitrate, berberine, caffeine and sodium benzoate, aid digestion, fluid infusion etc., but it is long that above method has the course for the treatment of, the shortcomings such as cost is high, in addition, adopt antibiotics or sulfa drugs treatment also to exist drug dose to control, when dosage is less or administration time more in short-term, its produce effects is slow, the problems such as weak curative effect and easy recurrence.
Summary of the invention
The present invention is directed to the defect that exists in above prior art, a kind of pharmaceutical preparation and application thereof that is used for the treatment of calf diarrhea is provided, have the effect that cost is low, the treatment calf diarrhea is effective and cure rate is high.
The present invention is achieved by the following technical programs, and a kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion:
Gentamycin sulfate: 5.0～11 parts;
Rhizoma Corydalis: 15～30 parts;
Yeast powder: 15～20 parts;
Alumen: 15～30 parts;
Sodium fulvate: 15～25 parts;
Flos Caryophylli: 15～25 parts;
Radix orixae japonicae: 15～30 parts;
Fructus Evodiae: 15～30 parts;
Cortex Cinnamomi: 15～25 parts.
The present invention is used for the treatment of the pharmaceutical preparation of calf diarrhea, be combined with by Chinese medicine and western medicine, both reached the effect that reduces costs, can make again in pharmaceutical preparation and have synergistic function preferably between each composition, realize the effect of therapeutic alliance, has therapeutic effect good, rapid-action, the effect that treatment time is short.The present invention adopts gentamycin sulfate can realize multiple gram-negative bacteria and positive bacteria are played the effect that suppresses and sterilize, and by the combined effect in conjunction with Rhizoma Corydalis, yeast powder and Alumen, thereby realize the effect for the treatment of diarrhea in livestock, the diarrhoea that is particularly useful for treating calf.Pharmaceutical preparation of the present invention has advantages of that not only treatment diarrhoea is effective and cure rate is high, also has a cost low, the advantage that composition proportion is reasonable, easy to use and toxicity is low.
In the above-mentioned pharmaceutical preparation that is used for the treatment of calf diarrhea, described gentamycin sulfate is the aminoglycosides broad ectrum antibiotic, multiple gram-negative bacteria and positive bacteria all had antibacterial and bactericidal action, as stronger to effects such as the gram-negative bacteria such as bacillus pyocyaneus, aerobacteria, pneumobacillus, Salmonella, escherichia coli and Bacillus proteus and golden Portugal bacterium.
In the above-mentioned pharmaceutical preparation that is used for the treatment of calf diarrhea, the described unit Papaveraceae Corydalis herbaceos perennial of acting like a bully, be the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.Li Shizhen (1518-1593 A.D.) is concluded Rhizoma Corydalis in Compendium of Material Medica have " invigorate blood circulation, promoting the circulation of QI, pain relieving, diuresis " four large effects.The present invention adopts Rhizoma Corydalis and the sulphuric acid GENTAMICIN is mould, Alumen and yeast powder are united to use and had synergistic function, can better realize curing diarrhoea effect and treatment time fast advantage.
In the above-mentioned pharmaceutical preparation that is used for the treatment of calf diarrhea, described Alumen it is generally acknowledged to have the detoxifcation parasite killing in Chinese medicine, dampness removing to stop itchin, hemostasis antidiarrheal, the effect of heat clearing away expectorant.And that the present invention adopts Alumen also to have is antibiotic, the effects such as anti-trichomonas vaginitis.Described Alumen can suppress the mucous membrane of small intestine secretion and play the antidiarrheal effect, can also make local little vasoconstriction, and make blood coagulation, thereby have the local hemostasis effect.Simultaneously, described Alumen can absorb moisture from cell, makes cell generation syneresis, reduces glandular secretion, reduces the inflammation exudate; Can be combined into serum albumin the proteinate that is insoluble in water and precipitate again, make tissue or wound surface present drying, thereby have the effect of convergence dampness, and help antiinflammatory.
In the above-mentioned pharmaceutical preparation that is used for the treatment of calf diarrhea, described yeast powder adopts conventional yeast powder raw material to get final product.Described yeast powder is a class single cell protein, is to use the yeast that several kinds of carbon source and nitrogenous source utilize yeast to cultivate as nutrient source the product that drying makes.The present invention utilizes yeast powder to contain the preparation of the vitamin Bs such as a certain amount of sulfanilamide, riboflavin and nicotinic acid, pantothenic acid, choline, and has good synergistic function between Alumen and gentamycin sulfate, also is applicable to the deficiency disease of dyspepsia and vitamin B.Adopt simultaneously yeast powder and other composition of the present invention to unite use, also have many advantages such as save time, method is better grasped.
In the above-mentioned pharmaceutical preparation that is used for the treatment of calf diarrhea, as preferably, described pharmaceutical preparation is mainly by the ingredients of following weight portion:
Gentamycin sulfate: 8.0～10 parts;
Rhizoma Corydalis: 20～25 parts;
Yeast powder: 16～19 parts;
Alumen: 20～25 parts;
Sodium fulvate: 17～23 parts;
Flos Caryophylli: 17～23 parts;
Radix orixae japonicae: 17～28 parts;
Fructus Evodiae: 17～28 parts;
Cortex Cinnamomi: 17～23 parts.
In the above-mentioned pharmaceutical preparation that is used for the treatment of calf diarrhea, as further preferred, described pharmaceutical preparation is mainly by the ingredients of following weight portion:
Gentamycin sulfate: 8.5～9.5 parts;
Rhizoma Corydalis: 22～23 parts;
Yeast powder: 17～18 parts;
Alumen: 21～23 parts;
Sodium fulvate: 21～23 parts;
Flos Caryophylli: 21～23 parts;
Radix orixae japonicae: 26～28 parts;
Fructus Evodiae: 26～28 parts;
Cortex Cinnamomi: 21～23 parts.
In the above-mentioned pharmaceutical preparation that is used for the treatment of calf diarrhea, as most preferably, described pharmaceutical preparation is mainly by the ingredients of following weight portion:
Gentamycin sulfate: 8.5 parts;
Rhizoma Corydalis: 24 parts;
Yeast powder: 18 parts;
Alumen: 22 parts;
Sodium fulvate: 22 parts;
Flos Caryophylli: 22 parts;
Radix orixae japonicae: 27 parts;
Fructus Evodiae: 27 parts;
Cortex Cinnamomi: 22 parts.
In sum, the present invention has the following advantages
The pharmaceutical preparation that is used for the treatment of calf diarrhea of the present invention, have advantages of that cost is low, treat the calf diarrhea excellent in efficiency, treatment time is short and cure rate is high.And have synergistic function between each composition, pharmaceutical preparation of the present invention also has that stomach invigorating is regulated the flow of vital energy, anti-inflammation, astringing to arrest diarrhea, pain easing and hemostasis effect.The pharmaceutical preparation of the present invention of clinical proof is dyspepsia, the gastroenteritis of various animals, the sick first-selected good medicine such as suffer from diarrhoea, have blood in stool.
The specific embodiment
, below by specific embodiment, technical scheme of the present invention is described in further detail, but the present invention is not limited to these embodiment.
Embodiment 1
A kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion:
Gentamycin sulfate: 5.0 parts; Rhizoma Corydalis: 30 parts; Yeast powder: 20 parts; Alumen: 30 parts; Sodium fulvate: 25 parts; Flos Caryophylli: 25 parts; Radix orixae japonicae: 30 parts; Fructus Evodiae: 30 parts; Cortex Cinnamomi: 25 parts.
This pharmaceutical preparation adopts general method preparation to get final product, and in particular, mix homogeneously after the above-mentioned raw materials pulverizing is made powdered pharmaceutical preparations get final product.
Be 5g～8g by each consumption while being used for the treatment of calf diarrhea.During use, get the said medicine preparation appropriate, with warm water, brew all rear oral getting final product of accent.
Embodiment 2
A kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion:
Gentamycin sulfate: 12 parts; Rhizoma Corydalis: 15 parts; Yeast powder: 15 parts; Alumen: 20 parts; Sodium fulvate: 15 parts; Flos Caryophylli: 15 parts; Radix orixae japonicae: 15 parts; Fructus Evodiae: 15 parts; Cortex Cinnamomi: 15 parts.
This pharmaceutical preparation adopts general method preparation to get final product, and in particular, mix homogeneously after the above-mentioned raw materials pulverizing is made powdered pharmaceutical preparations get final product.
Be 5g～8g by each consumption while being used for the treatment of calf diarrhea.During use, get the said medicine preparation appropriate, with warm water, brew all rear oral getting final product of accent.
Embodiment 3
A kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion:
Gentamycin sulfate: 8.0 parts; Rhizoma Corydalis: 25 parts; Yeast powder: 16 parts; Alumen: 15 parts; Sodium fulvate: 16 parts; Flos Caryophylli: 17 parts; Radix orixae japonicae: 17 parts; Fructus Evodiae: 17 parts; Cortex Cinnamomi: 18 parts.
This pharmaceutical preparation adopts general method preparation to get final product, and in particular, mix homogeneously after the above-mentioned raw materials pulverizing is made powdered pharmaceutical preparations get final product.
Be 5g～8g by each consumption while being used for the treatment of calf diarrhea.During use, get the said medicine preparation appropriate, with warm water, brew all rear oral getting final product of accent.
Embodiment 4
A kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion:
Gentamycin sulfate: 10 parts; Rhizoma Corydalis: 20 parts; Yeast powder: 19 parts; Alumen: 20 parts; Sodium fulvate: 17 parts; Flos Caryophylli: 18 parts; Radix orixae japonicae: 18 parts; Fructus Evodiae: 18 parts; Cortex Cinnamomi: 19 parts.
This pharmaceutical preparation adopts general method preparation to get final product, and in particular, mix homogeneously after the above-mentioned raw materials pulverizing is made powdered pharmaceutical preparations get final product.
Be 5g～8g by each consumption while being used for the treatment of calf diarrhea.During use, get the said medicine preparation appropriate, with warm water, brew all rear oral getting final product of accent.
Embodiment 5
A kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion:
Gentamycin sulfate: 8.5 parts; Rhizoma Corydalis: 23 parts; Yeast powder: 18 parts; Alumen: 25 parts; Sodium fulvate: 18 parts; Flos Caryophylli: 19 parts; Radix orixae japonicae: 19 parts; Fructus Evodiae: 19 parts; Cortex Cinnamomi: 20 parts.
This pharmaceutical preparation adopts general method preparation to get final product, and in particular, mix homogeneously after the above-mentioned raw materials pulverizing is made powdered pharmaceutical preparations get final product.
Be 5g～8g by each consumption while being used for the treatment of calf diarrhea.During use, get the said medicine preparation appropriate, with warm water, brew all rear oral getting final product of accent.
Embodiment 6
A kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion:
Gentamycin sulfate: 9.5 parts; Rhizoma Corydalis: 22 parts; Yeast powder: 17 parts; Alumen: 21 parts; Sodium fulvate: 19 parts; Flos Caryophylli: 19 parts; Radix orixae japonicae: 25 parts; Fructus Evodiae: 25 parts; Cortex Cinnamomi: 25 parts.This pharmaceutical preparation adopts general method preparation to get final product, and in particular, mix homogeneously after the above-mentioned raw materials pulverizing is made powdered pharmaceutical preparations get final product.
Be 5g～8g by each consumption while being used for the treatment of calf diarrhea.During use, get the said medicine preparation appropriate, with warm water, brew all rear oral getting final product of accent.
Embodiment 7
A kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion: gentamycin sulfate: 8.5 parts; Rhizoma Corydalis: 24 parts; Yeast powder: 18 parts; Alumen: 22 parts; Sodium fulvate: 22 parts; Flos Caryophylli: 22 parts; Radix orixae japonicae: 27 parts; Fructus Evodiae: 27 parts; Cortex Cinnamomi: 22 parts.
This pharmaceutical preparation adopts general method preparation to get final product, and in particular, mix homogeneously after the above-mentioned raw materials pulverizing is made powdered pharmaceutical preparations get final product.
Be 5g～8g by each consumption while being used for the treatment of calf diarrhea.During use, get the said medicine preparation appropriate, with warm water, brew all rear oral getting final product of accent.
Embodiment 8
A kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion:
Gentamycin sulfate: 11 parts; Rhizoma Corydalis: 28 parts; Yeast powder: 16 parts; Alumen: 28 parts; Sodium fulvate: 21 parts; Flos Caryophylli: 21 parts; Radix orixae japonicae: 26 parts; Fructus Evodiae: 26 parts; Cortex Cinnamomi: 21 parts.
This pharmaceutical preparation adopts general method preparation to get final product, and in particular, mix homogeneously after the above-mentioned raw materials pulverizing is made powdered pharmaceutical preparations get final product.
Be 5g～8g by each consumption while being used for the treatment of calf diarrhea.During use, get the said medicine preparation appropriate, with warm water, brew all rear oral getting final product of accent.
Embodiment 9
A kind of pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion:
Gentamycin sulfate: 9.0 parts; Rhizoma Corydalis: 23 parts; Yeast powder: 19 parts; Alumen: 25 parts; Sodium fulvate: 22 parts; Flos Caryophylli: 22 parts; Radix orixae japonicae: 27 parts; Fructus Evodiae: 27 parts; Cortex Cinnamomi: 22 parts.
This pharmaceutical preparation adopts general method preparation to get final product, and in particular, mix homogeneously after the above-mentioned raw materials pulverizing is made powdered pharmaceutical preparations get final product.
Be 5g～8g by each consumption while being used for the treatment of calf diarrhea.During use, get the said medicine preparation appropriate, with warm water, brew all rear oral getting final product of accent.
Choose at random the relative medicine preparation that obtains in above-mentioned example and carry out the clinical effectiveness test, verify the clinical effectiveness of pharmaceutical preparation treatment calf diarrhea of the present invention.In particular, select 91 of trouble diarrhoeal diseases calves to carry out clinical trial, by take pharmaceutical preparation of the present invention as test group, connect soup take the new toxin of sulphuric acid and grey Pueraria lobota a kind of reed mentioned in ancient books and compare test as matched group, result shows that pharmaceutical preparation of the present invention has higher therapeutic effect and cure rate.
Sick calf criterion
The Clinical symptoms of Calves Diarrhea mainly contains: spirit is gloomy, and the band hemoperitoneum is rushed down, the feces stench, or be mixed with blood streak bubble, acute a large amount of diarrhoea, dehydration, self poisoning, heart failure, fervescence, abdominal distention, stomachache, useless food, the Clinical symptoms such as short of breath
Test method and administrated method
Above-mentioned 91 of the trouble diarrhoeal diseases calves of selecting are divided into three groups to be tested accordingly.First group is test group, adopts pharmaceutical preparation of the present invention to treat: second group is matched group 1, adopts antibiotherapy, namely use the new toxin of sulphuric acid (buying from Henan honest animal pharmaceutical estate company limited) to treat, 2 times on the one, be used in conjunction three days, carry out medication by its explanation.The 3rd group is matched group 2, adopt Chinese medicine preparation to treat, described Chinese medicine preparation namely uses grey Pueraria lobota a kind of reed mentioned in ancient books to connect soup (square medicine: Rhizoma Atractylodis, Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Alismatis, Semen Plantaginis, Flos Lonicerae, Fructus Rosae Laevigatae, Rhizoma Cimicifugae, the Radix Aucklandiae, Semen Arecae, Massa Medicata Fermentata, Radix Glycyrrhizae, dosage was determined with the age), 1 dose of every day, 2 merging of decocting gavage after temperature.
The administrated method of pharmaceutical preparation of the present invention in above-mentioned test group: brew after mixing well and carry out oral getting final product with warm water during use, consumption is: each 5～8 grams of calf, consumption is pressed 0.1g-0.15g/kg.
Curative effect determinate standard
The A criterion of cure: the clinical indices such as calf body temperature, respiratory frequency are normal, without the diarrhoea phenomenon.
The effective standard of B: the clinical indices such as calf body temperature, respiratory frequency take a turn for the better to some extent, and the diarrhoea phenomenon alleviates.
The invalid standard of C: the calf state of an illness is not felt any better
Concrete result of the test is as shown in table 1 below.
Table 1:
Can find out from above-mentioned table 1, wherein test group is suffered from totally 32 of diarrhoea calves, wherein cures 22,8 of certain effects is arranged, invalid 2.And find that in actual tracing process pharmaceutical preparation of the present invention is particularly evident to the diarrhea treatment effect, start after 1～2 day that to suffering from the medication of diarrhoeal diseases calf positive effect is arranged, medication can reach promising result about 3 days substantially, and supervise is observed, morbidity is less again, has advantages of and cures the rear recurrence that is difficult for.
Wherein, matched group 1 is suffered from totally 29 of diarrhoea calves, wherein cures 18,9 of certain effects is arranged, invalid 2.And find in actual tracing process, to suffering from the medication of diarrhoea calf, start after 2～3 days to take a turn for the better, substantially can reach promising result about 5 days, Ineffective Cases continues to be difficult for curing after medication.
Wherein, matched group 2 is suffered from totally 30 of diarrhoea calves, wherein cures 9,14 of certain effects is arranged, invalid 7.And find in actual tracing process, medication starts after 3 days to take a turn for the better, and substantially can reach promising result about 5 days, and Ineffective Cases continues to be difficult for curing after medication.
Following table 2 is that the pharmaceutical preparation of the invention described above and matched group 1 and matched group 2 are used for the treatment of and suffer from after the diarrhoea calf corresponding index that the data analysis according to table 1 obtains.
Table 2:
According to the interpretation of result of above-mentioned table 2 with relatively can find out, it is high that pharmaceutical preparation of the present invention has a cure rate, and inefficiency is low.And pharmaceutical preparation of the present invention is compared with matched group: it is fast also to have an onset time, and recovery time is short.On price, slightly higher than antibiotics price, but lower than Chinese medicine price; Comprehensively as seen: pharmaceutical preparation of the present invention than other two groups have therapeutic effect obviously, be difficult for that recurrence, cost are lower, simple operation and other advantages.
Specific embodiment described in the present invention is only to the explanation for example of the present invention's spirit.Those skilled in the art can make various modifications or supplement or adopt similar mode to substitute described specific embodiment, but can't depart from spirit of the present invention or surmount the defined scope of appended claims.
Although the present invention has been made a detailed description and has quoted as proof some specific embodiments, to those skilled in the art, only otherwise it is obvious leaving that the spirit and scope of the present invention can make various changes or revise.
Claims (4)
1. pharmaceutical preparation that is used for the treatment of calf diarrhea, described pharmaceutical preparation are mainly by the ingredients of following weight portion:
Gentamycin sulfate: 5.0～11 parts;
Rhizoma Corydalis: 15～30 parts;
Yeast powder: 15～20 parts;
Alumen: 15～30 parts;
Sodium fulvate: 15～25 parts;
Flos Caryophylli: 15～25 parts;
Radix orixae japonicae: 15～30 parts;
Fructus Evodiae: 15～30 parts;
Cortex Cinnamomi: 15～25 parts.
2. be used for the treatment of according to claim 1 the pharmaceutical preparation of calf diarrhea, it is characterized in that, described compound medicinal formulation is mainly by the ingredients of following weight portion:
Gentamycin sulfate: 8.0～10 parts;
Rhizoma Corydalis: 20～25 parts;
Yeast powder: 16～19 parts;
Alumen: 20～25 parts;
Sodium fulvate: 17～23 parts;
Flos Caryophylli: 17～23 parts;
Radix orixae japonicae: 17～28 parts;
Fructus Evodiae: 17～28 parts;
Cortex Cinnamomi: 17～23 parts.
3. the described pharmaceutical preparation that is used for the treatment of calf diarrhea according to claim 1 and 2, is characterized in that, described compound medicinal formulation is mainly by the ingredients of following weight portion:
Gentamycin sulfate: 8.5～9.5 parts;
Rhizoma Corydalis: 22～23 parts;
Yeast powder: 17～18 parts;
Alumen: 21～23 parts;
Sodium fulvate: 21～23 parts;
Flos Caryophylli: 21～23 parts;
Radix orixae japonicae: 26～28 parts;
Fructus Evodiae: 26～28 parts;
Cortex Cinnamomi: 21～23 parts.
4. be used for the treatment of according to claim 1 the pharmaceutical preparation of calf diarrhea, it is characterized in that, described compound medicinal formulation is mainly by the ingredients of following weight portion:
Gentamycin sulfate: 8.5 parts;
Rhizoma Corydalis: 24 parts;
Yeast powder: 18 parts;
Alumen: 22 parts;
Sodium fulvate: 22 parts;
Flos Caryophylli: 22 parts;
Radix orixae japonicae: 27 parts;
Fructus Evodiae: 27 parts;
Cortex Cinnamomi: 22 parts.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385928A (en) * | 2013-07-10 | 2013-11-13 | 吉林大学 | Compound medical preparation for curing diarrhea of young livestock and applications thereof |
| CN104189647A (en) * | 2014-09-17 | 2014-12-10 | 山东省畜牧总站 | Medicine composition for treating damp-heat calf diarrhea and preparation method thereof |
| CN104644829A (en) * | 2014-06-10 | 2015-05-27 | 陈莉芬 | Antidiarrheal medicine |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1618311A (en) * | 2003-11-17 | 2005-05-25 | 张静兴 | Method for prodn. composite herb medicine forage additive for pig |
| CN1640415A (en) * | 2004-01-06 | 2005-07-20 | 山西晋新药业有限责任公司 | Medicine for treating diarrhoea in children and its preparation |
| CN101972274A (en) * | 2010-11-12 | 2011-02-16 | 昆明理工大学 | Application of fulvic acid sodium in preparing drugs for treating diarrhea |
| CN101991613A (en) * | 2010-11-03 | 2011-03-30 | 庞永中 | Diarrhea and dysentery arresting medicine and preparation method thereof |
-
2013
- 2013-07-10 CN CN2013102926147A patent/CN103385957A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1618311A (en) * | 2003-11-17 | 2005-05-25 | 张静兴 | Method for prodn. composite herb medicine forage additive for pig |
| CN1640415A (en) * | 2004-01-06 | 2005-07-20 | 山西晋新药业有限责任公司 | Medicine for treating diarrhoea in children and its preparation |
| CN101991613A (en) * | 2010-11-03 | 2011-03-30 | 庞永中 | Diarrhea and dysentery arresting medicine and preparation method thereof |
| CN101972274A (en) * | 2010-11-12 | 2011-02-16 | 昆明理工大学 | Application of fulvic acid sodium in preparing drugs for treating diarrhea |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385928A (en) * | 2013-07-10 | 2013-11-13 | 吉林大学 | Compound medical preparation for curing diarrhea of young livestock and applications thereof |
| CN104644829A (en) * | 2014-06-10 | 2015-05-27 | 陈莉芬 | Antidiarrheal medicine |
| CN104189647A (en) * | 2014-09-17 | 2014-12-10 | 山东省畜牧总站 | Medicine composition for treating damp-heat calf diarrhea and preparation method thereof |
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Application publication date: 20131113 |