CN103385768A - Tail loading device for swimming of laboratory mouse - Google Patents
Tail loading device for swimming of laboratory mouse Download PDFInfo
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- CN103385768A CN103385768A CN2013103059500A CN201310305950A CN103385768A CN 103385768 A CN103385768 A CN 103385768A CN 2013103059500 A CN2013103059500 A CN 2013103059500A CN 201310305950 A CN201310305950 A CN 201310305950A CN 103385768 A CN103385768 A CN 103385768A
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- 230000009182 swimming Effects 0.000 title claims abstract description 20
- 241000699670 Mus sp. Species 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims description 5
- 229910000831 Steel Inorganic materials 0.000 claims description 4
- 239000010959 steel Substances 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 241000700159 Rattus Species 0.000 claims 8
- 238000000034 method Methods 0.000 description 7
- 241000581650 Ivesia Species 0.000 description 3
- 230000004308 accommodation Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241001417092 Macrouridae Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 235000009233 Stachytarpheta cayennensis Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000011133 lead Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
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Abstract
本发明提供了一种实验用鼠游泳尾部负重装置，包括内衬套和外衬套，所述内衬套为锥形，内衬套沿圆锥母线方向开设有连通两端口的条形开口，条形开口对应的圆心角小于180°，内衬套开有外螺纹；所述外衬套内表面为截顶圆锥形，外衬套内表面开有与外螺纹相适配的内螺纹。本发明结构简单，实用性好，能快速、有效地对实验用鼠进行负重，且不会损伤实验用鼠。
The invention provides a weight-bearing device for rat swimming tails for experiments, which includes an inner bushing and an outer bushing, the inner bushing is conical, and the inner bushing is provided with a strip-shaped opening connecting the two ports along the direction of the generatrix of the cone. The central angle corresponding to the shaped opening is less than 180°, and the inner bushing is provided with external threads; the inner surface of the outer bushing is truncated conical, and the inner surface of the outer bushing is provided with internal threads matching the external threads. The invention has the advantages of simple structure and good practicability, and can quickly and effectively load the experimental mice without damaging the experimental mice.
Description
Technical field
The present invention relates to a kind of experimental apparatus, especially relate to a kind of experimental rat swimming afterbody load-bearing device.
Background technology
Tired model is a kind of animal model that in life science, a lot of experimental projects all can use, and present tired modeling method commonly used is the exercise fatigue modeling.In the exercise fatigue model manufacturing, " swimming causes tired " is easy with its method, the modeling effect better, the modeling evaluation system is more perfect, widely applicable, and becomes the first-selection in the exercise fatigue modeling.
The selected laboratory animal of tired model of swimming is mainly rat and mice.As everyone knows, no matter be rat or mice, stronger Burden-Swimming Ability of KM is all arranged, reach tired speed in order to accelerate experimental subject, we tend to add certain heavy burden with it at experimental subject in the experiment actual mechanical process, and concluding common heavy burden method is mainly to bear a heavy burden or with fine rule, weight is bundled in back at the experimental rat afterbody to bear a heavy burden.
The method that the afterbody heavy burden is adopted is generally that tinsel is wound in the experimental rat afterbody.While using the method, the blue or green damage of the stasis of blood in various degree all appears in rat and mouse tail, and during swimming because of the swing of afterbody, tinsel is slippage very easily., for fixing of reinforcement metal silk, can adopt plasticine or resin to strengthen fixing, but above two kinds of materials itself have constant weight, bear a heavy burden when consumption is many overweight, can not reach firm effect when consumption is few, and during operating cost, operate extremely inconvenient while changing different heavy burdens.
Bearing a heavy burden in back is mainly the heavy burden method that shoulder and the front by mice is bundled in back with weight with fine rule or cord.But the mice health is soft, the bad grasp of binding dynamics, and the mice limbs are little, are easy to shake off from the binding cotton rope, can't complete binding preferably, and the method are also more time-consuming.
Summary of the invention
The present invention aims to provide a kind of simple and practical experimental rat swimming load-bearing device, and it is simple in structure, can bear a heavy burden to experimental rat quickly and efficiently.
Technical scheme of the present invention is a kind of experimental rat swimming afterbody load-bearing device, comprise neck bush and external bushing, described neck bush is taper, and neck bush offers the strip gab that is communicated with two-port along the element of cone direction, central angle corresponding to strip gab is less than 180 °, and neck bush has external screw thread; Described external bushing inner surface is frustroconical, and the external bushing inner surface has the female thread suitable with external screw thread.
Preferably, described external screw thread one end is positioned at neck bush small end place, and externally threaded length is at least 3/5 of neck bush total length.
Preferably, described female thread covers the whole inner surface of external bushing.
Preferably, described neck bush is identical with external bushing inner surface tapering.
Preferably, the tapering of described neck bush is 0.145 to 0.372.
Preferably, also comprise the counterweight circle, described counterweight snare is at the neck bush outer surface, and counterweight circle internal diameter is greater than neck bush small end external diameter and less than the large end external diameter of neck bush, and counterweight circle internal diameter is less than the large end external diameter of external bushing.
Preferably, there is scale or the color of sign weight on described counterweight circle surface, and the specification of counterweight circle has 0.1g, 0.2g, 0.5g, 1g, 2g, 5g.
Preferably, described neck bush length is 12-18mm, hold internal diameter greatly is that 4-4.5mm, small end internal diameter are that 3.2-3.7mm, wall thickness are 0.8-1.2mm, the width at the large end of described strip gab place is that the width at 1.8-2.2mm, small end place is 1.4-1.8mm, and described external thread length is 8-15mm; Described external bushing length is 6-9mm, hold internal diameter 5.3-5.8mm, small end internal diameter greatly is that 4.5-5.6mm, wall thickness are 1.3-1.7mm.
Preferably, described neck bush length is 18-24mm, hold internal diameter greatly is that 6-7mm, small end internal diameter are that 5-6mm, wall thickness are 0.8-1.2mm, the width at the large end of described strip gab place is that the width at 3-3.35mm, small end place is 2.5-3mm, and described external thread length is 12-20mm; Described external bushing length is 8.5-12.5mm, hold internal diameter 5-7mm, small end internal diameter greatly is that 3.5-4.6mm, wall thickness are 1.3-1.7mm.
Preferably, the material of described neck bush and external bushing is plastics or steel.
The present invention is simple in structure, and practicality is good, can bear a heavy burden to experimental rat quickly and efficiently, and can not use Mus by injury experiment.
Description of drawings
Fig. 1 is that structure of the present invention splits schematic diagram;
Fig. 2 is structural representation of the present invention;
In figure: 1-neck bush, 2-external bushing, 3-external screw thread, 4-female thread, 5-strip gab, 6-counterweight circle.
The specific embodiment
Below in conjunction with accompanying drawing, the present invention is described in further detail.
As depicted in figs. 1 and 2, the invention provides a kind of experimental rat swimming afterbody load-bearing device, comprise neck bush 1 and external bushing 2, described neck bush 1 is taper, neck bush 1 offers the strip gab 5 that is communicated with two-port along the element of cone direction, the central angle of strip gab 5 correspondences is less than 180 °, and the length of neck bush 1 is greater than external diameter, and neck bush 1 has external screw thread 3; Described external bushing 2 inner surfacies are frustroconical, and external bushing 2 inner surfacies have the female thread 4 suitable with external screw thread 3.During operation, neck bush 1 and external bushing 2 are inserted in respectively the experimental rat afterbody, make neck bush 1 small end and the large end in contact of external bushing 2, screw screw thread, neck bush 1 deforms under the extruding of external bushing 2 inner surfacies owing to having strip gab 5, makes neck bush 1 internal diameter diminish, and finally clamps the experimental rat afterbody, when needs adjustment heavy burden weight, can use this device of Different Weight specification instead.
Preferably, external screw thread 3 one ends are positioned at neck bush 1 small end place, and the length of external screw thread 3 is at least 3/5 of neck bush 1 total length.Can regulate more the range of accommodation of neck bush 1 internal diameter, simultaneously hand-held during handled easily.
Preferably, female thread 4 covers the whole inner surface of external bushing 2.Can regulate more the range of accommodation of neck bush 1 internal diameter.
Preferably, neck bush 1 is identical with external bushing 2 inner surface taperings.Convenient inside and outside lining coordinates.
Preferably, the tapering of neck bush 1 is 0.145 to 0.372.
Preferably, also comprise counterweight circle 6, described counterweight circle 6 is enclosed within neck bush 1 outer surface, and counterweight circle 6 internal diameters are greater than neck bush 1 small end external diameter and less than the large end external diameter of neck bush 1, and counterweight circle 6 internal diameters are less than the large end external diameter of external bushing 2.Can need to be inserted in the counterweight circle 6 of Different Weight according to different heavy burdens.
Preferably, there is scale or the color of sign weight on counterweight circle 6 surfaces, and the specification of counterweight circle 6 has 0.1g, 0.2g, 0.5g, 1g, 2g, 5g.The material of counterweight circle 6 can be steel, copper or lead, the convenient heavy burden weight of regulating.
Preferably, neck bush 1 length is 12-18mm, hold internal diameter greatly is that 4-4.5mm, small end internal diameter are that 3.2-3.7mm, wall thickness are 0.8-1.2mm, the width at described strip gab 5 large end places is that the width at 1.8-2.2mm, small end place is 1.4-1.8mm, and described external screw thread 3 length are 8-15mm; Described external bushing 2 length are 6-9mm, hold internal diameter 5.3-5.8mm, small end internal diameter greatly is that 4.5-5.6mm, wall thickness are 1.3-1.7mm.During practical application, concrete neck bush 1 length can be selected 15mm, hold internal diameter greatly is that 4mm, small end internal diameter are that 3.5mm, wall thickness are 1mm, and external screw thread 3 length are 13mm, and the width at strip gab 5 large end places is 2mm, and the width at small end place is 1.75mm; Concrete external bushing 2 length can be 7.5mm, hold internal diameter to can be 5.67mm greatly, the small end internal diameter is that 5.42mm, wall thickness are 1.5mm, and the depth of thread of inside and outside lining is 0.3 ± 0.02mm.
Preferably, neck bush 1 length is 18-24mm, hold internal diameter greatly is that 6-7mm, small end internal diameter are that 5-6mm, wall thickness are 0.8-1.2mm, the width at described strip gab 5 large end places is that the width at 3-3.35mm, small end place is 2.5-3mm, and external screw thread 3 length are 12-20mm; Described external bushing 2 length are 8.5-12.5mm, hold internal diameter 5-7mm, small end internal diameter greatly is that 3.5-4.6mm, wall thickness are 1.3-1.7mm.During practical application, concrete neck bush 1 length can be 21mm, holds internal diameter greatly is that 6.5mm, small end internal diameter are 5.6mm, and wall thickness is 1mm, and external screw thread 3 length are 15mm, and the width at strip gab 5 large end places is 3.25mm, and the width at small end place is 2.8mm; Concrete external bushing 2 length can be 10.5mm, hold internal diameter greatly is that 5.9mm, small end internal diameter are that 4.1mm, wall thickness are 1.5mm, and the depth of thread of inside and outside lining is 0.3 ± 0.02mm.
Preferably, the material of neck bush 1 and external bushing 2 is plastics or steel.External bushing assembling in convenient, and guarantee the reliability of using
In experiment, Kunming kind white mice to 350 all ages and classes, body weight, sex is measured, and obtains following mousetail morphological data: tail is conical, length 7.8-11.7cm, the tail root diameter (RD) is 3.4-5.8mm, and hence one can see that, and the mouse tail tapering is 0.145-0.372.Simultaneously, rat to 36 different sizes, age, body weight is measured, and obtains following rat tail morphological data: tail is conical, length 15.0cm-22.0cm, the tail root diameter (RD) is 6.92mm-11.01mm, and hence one can see that, and the rat tails tapering is 0.157-0.367.
Certainly; the present invention also can have other various embodiments; in the situation that do not deviate from spirit of the present invention and essence thereof; those of ordinary skill in the art can make according to the present invention various corresponding changes and distortion, but these corresponding changes and distortion all should belong to the protection domain of the appended claim of the present invention.
Claims (10)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310305950.0A CN103385768B (en) | 2013-07-19 | 2013-07-19 | Experimental rat swimming afterbody load-bearing device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310305950.0A CN103385768B (en) | 2013-07-19 | 2013-07-19 | Experimental rat swimming afterbody load-bearing device |
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| Publication Number | Publication Date |
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| CN103385768A true CN103385768A (en) | 2013-11-13 |
| CN103385768B CN103385768B (en) | 2015-08-26 |
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| CN201310305950.0A Expired - Fee Related CN103385768B (en) | 2013-07-19 | 2013-07-19 | Experimental rat swimming afterbody load-bearing device |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104720831A (en) * | 2015-04-16 | 2015-06-24 | 温州医科大学附属第一医院 | Measurement method and measurement equipment special for exhaustive swimming experiments of rats and mice |
| CN107484676A (en) * | 2017-08-31 | 2017-12-19 | 戴霞 | A kind of big mouse resistive exercise heavy burden mesh bag |
| CN108387440A (en) * | 2018-01-17 | 2018-08-10 | 辽宁工程技术大学 | A kind of rock frictional test fixture and application method |
| CN108888382A (en) * | 2018-05-22 | 2018-11-27 | 上海市同济医院 | A kind of blood sampling of mouse tail vein and injection folder |
| CN109006689A (en) * | 2018-09-13 | 2018-12-18 | 中国辐射防护研究院 | A kind of method for building up of the rat animal model of physical fatigue |
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| CN202514399U (en) * | 2012-03-13 | 2012-11-07 | 陕西师范大学 | Animal resistive exercise load apparatus |
| CN203369966U (en) * | 2013-07-19 | 2014-01-01 | 胡尧 | Tail load bearing device for swimming of laboratory mice |
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2013
- 2013-07-19 CN CN201310305950.0A patent/CN103385768B/en not_active Expired - Fee Related
Patent Citations (5)
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| US20080168948A1 (en) * | 2007-01-11 | 2008-07-17 | Starr Life Sciences Corp. | Small animal restraining device with non-traumatic animal loading device |
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Non-Patent Citations (3)
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| 李俊平等: "《常用动物运动模型的方式与发展》", 《北京体育大学学报》 * |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104720831A (en) * | 2015-04-16 | 2015-06-24 | 温州医科大学附属第一医院 | Measurement method and measurement equipment special for exhaustive swimming experiments of rats and mice |
| CN107484676A (en) * | 2017-08-31 | 2017-12-19 | 戴霞 | A kind of big mouse resistive exercise heavy burden mesh bag |
| CN108387440A (en) * | 2018-01-17 | 2018-08-10 | 辽宁工程技术大学 | A kind of rock frictional test fixture and application method |
| CN108888382A (en) * | 2018-05-22 | 2018-11-27 | 上海市同济医院 | A kind of blood sampling of mouse tail vein and injection folder |
| CN109006689A (en) * | 2018-09-13 | 2018-12-18 | 中国辐射防护研究院 | A kind of method for building up of the rat animal model of physical fatigue |
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| CN103385768B (en) | 2015-08-26 |
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Effective date of registration: 20190122 Address after: 610000 No. 1166 Liutai Avenue, Wenjiang District, Chengdu City, Sichuan Province Patentee after: Chengdu University of Traditional Chinese Medicine Address before: 610000 No. 2 Sports College Road, Wuhou District, Chengdu City, Sichuan Province Patentee before: Hu Yao |
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Granted publication date: 20150826 Termination date: 20190719 |