CN103355679B - Making method of chewable tablet with effect of enriching blood - Google Patents

Abstract

The invention belongs to the technical field of food processing and specifically relates to a making method of a chewable tablet with an effect of enriching blood. The method comprises the following steps: (1) pretreatment of raw materials; (2) superfine grinding of red jujube; (3) preparation of auxiliary materials; (4) granulation; (5) tabletting; and (6) packaging and sterilization. According to the chewable tablet prepared by the above method, peanut skin is combined with jujube. The chewable tablets can nourish spleen and stomach, has a good effect of enriching blood, and is of great advantage for human health. In comparison with a common drying method, the making method by lyophilization is used to effectively reduce loss of nutritional ingredients and retain nutritional ingredients of red jujube to the maximum to make the nutritional ingredients to be absorbed and utilized by human body.

Description

Preparation method of chewable tablet with blood-enriching effect

technical field

The invention belongs to the technical field of food processing, and in particular relates to a preparation method of a chewable tablet with the function of nourishing blood.

Background technique

Peanut red coat is a by-product of peanut products. Our country can produce about 600 tons every year. Except a small amount is used for pharmaceuticals, the rest are used as feed, and its nutritional and health value is not fully utilized. Peanut red coat is very rich in active ingredients, including lipids, sterols, pyrocatechol tannins, chrysophenin, and colorless delphinidin. Its taste is sweet, slightly bitter, neutral in nature, and has the effect of stopping bleeding and dispersing stasis. Peanut red coat can inhibit the dissolution of fibrin, increase the content of platelets, improve the quality of platelets, improve the defects of coagulation factors, strengthen the contraction function of capillaries, and promote the hematopoietic function of bone marrow. Therefore, it has obvious effects on various bleeding and bleeding-induced anemia, aplastic anemia and other diseases.

Jujube is not only a common food, but also a commonly used medicine. It can be eaten for a long time or used as a medicated diet. The health-care fruit with three major functions is known as "woody grain, good nourishing product". Jujube contains 18 kinds of amino acids, including 8 kinds of essential amino acids that cannot be synthesized by the human body, and two amino acids that cannot be synthesized in the body of young children, namely arginine and rough acid. Contains up to 3300mg/100g of vitamin P, which is an effective ingredient for the prevention and treatment of hypertension. In addition to the common polysaccharides, flavonoids, alkaloids, coumarins, etc. in jujube, with the in-depth research on the functional components and pharmacology of jujube in recent years, it is found that jujube also contains some other fruits that have little or no content, but have high physiological activity. special bioactive ingredients. Pharmacological studies have shown that jujube has the effects of increasing serum albumin, lowering blood cholesterol, and protecting the liver. Its cyclic adenosine monophosphate can enhance muscle strength, eliminate fatigue, dilate blood vessels, increase myocardial contractility, improve myocardial nutrition, and has a good effect on preventing and treating cardiovascular diseases.

Superfine pulverization can process the sample into micron or nanometer powder. The cold circulation system in the crushing process can maintain the nutritional content of peanut red coat and red dates. Peanut red coat and red dates contain crude fiber. After ultrafine grinding, the particle size becomes smaller, which effectively improves the solubility of red coat and red dates, so that the active ingredients in peanut red coat and red dates are easier to absorb. Improved resource utilization.

Chewable tablets refer to tablet preparations that are swallowed after melting the tablet by chewing or sucking. Compared with other product forms, tablet preparations have outstanding advantages: easy to carry, various forms of taking; fast absorption, high utilization of active substances; good dispersion state, easy to accept taste. By adding some xylitol, milk and other substances, the nutritional content and palatability can be increased. After being chewed, the tablet preparation can be taken even in the state of lack of water, especially suitable for the elderly and children. Chewable tablets are not only limited to medicines, but also widely used in other aspects such as health food.

Contents of the invention

In order to solve the above-mentioned technical problems, the present invention provides a method for making a chewable tablet with good taste and blood-enriching effect. The chewable tablet mainly contains peanut red coat, which itself has good blood-enriching effect. The combination of red dates further plays the role of enriching blood.

The preparation method of the chewable tablet with blood enriching effect comprises the following steps:

(1) Raw material pretreatment: After removing impurities from the peanut red coat, dry it at 50-60°C until its moisture content is 4-8%, and ultrafinely pulverize the dried peanut red coat to 500-1000 mesh to obtain red peanut powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum dry them for 4-12 hours under the condition of vacuum degree of 10-40Mpa, and ultrafinely grind the red dates after freeze-drying to 500-1000 mesh to obtain red dates pink;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 40-50 parts of red peanut powder, 20-30 parts of red date powder, 10-20 parts of sucrose, 6-10 parts of milk powder 1. 2-4 parts of xylitol, 1-3 parts of gum arabic; add 90% ethanol as a wetting agent to the above-mentioned raw materials, and keep stirring while adding, until it can be dispersed after being kneaded into a ball;

(4) Granulation: Put the kneaded raw materials in step (3) into a granulator for granulation, and then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 4-8%. The dried granules are passed through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 1-3 parts of magnesium stearate to the sieved granules, mix evenly, and then press the tablets with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated with a cobalt-60 radioactive source of 5-9kGy for 10-14 minutes to sterilize.

In step (2), freeze-dried red dates are pulverized by freeze-drying method. The principle and characteristics of freeze-drying are the same as those of vacuum drying of food materials and drying under normal pressure. The evaporation temperature is lower than that under normal pressure, which can effectively reduce the loss of nutrients. The red dates or wolfberry are dried by vacuum freeze-drying, which reduces the loss of nutrients. the

Principle of vacuum freeze-drying: It is known from physics that water has three phases, point O is the common point of the three phases, and OA is the melting point of ice. According to the principle of decreasing pressure and decreasing boiling point, as long as the pressure is below the triple point pressure (pressure below 646.5Pa, temperature below 0°C), the moisture in the material can be directly sublimated from water to water vapor without going through the liquid phase. According to this principle, the wet raw materials of food can be frozen below the freezing point first, so that the moisture in the raw materials can be turned into solid ice, and then in a suitable vacuum environment, the ice can be directly converted into steam and removed, and then used in the vacuum system The water vapor condenser condenses the water vapor, so that the material is dried. This method of obtaining drying by vacuum freezing is a process of water state change and movement, which occurs at low temperature and low pressure. Therefore, the basic principle of freeze drying is the mechanism of heat and mass transfer at low temperature and low pressure.

The advantages of vacuum freeze-drying are: because vacuum freeze-drying is carried out at low temperature and low pressure, and the water is directly sublimated, it endows the product with many special properties. For example, vacuum freeze-drying technology can also dehydrate heat-sensitive materials more thoroughly, and the dried medicine is very stable, which is convenient for long-term storage. Since the drying of the material is completed in a frozen state, compared with other drying methods, the physical structure and molecular structure of the material have minimal changes, and its organizational structure and appearance are better preserved. During the vacuum freeze-drying process, the material does not have the problem of surface hardening, and its interior forms a porous sponge, so it has excellent rehydration properties and can return to the state before drying in a short time. Since the drying process is carried out at a very low temperature and the air is basically isolated, it effectively inhibits the biological, chemical or physical changes of the heat-sensitive substances, and better preserves the active substances in the raw materials, as well as the preservation of the raw materials. color.

The above-mentioned tablet press is a single tablet press.

The above-mentioned granulator is a swing granulator.

Preferably, the parts by weight of the above-mentioned raw materials are as follows: 45 parts of peanut red coat powder, 25 parts of red date powder, 15 parts of sucrose, 8 parts of milk powder, 3 parts of xylitol, 2 parts of gum arabic, and 2 parts of magnesium stearate .

As an improvement of the present invention, while using peanut red coat and red dates as the main raw materials, donkey-hide gelatin, wolfberry, and saffron are supplemented; the combination of the above substances is not simply a combination of raw materials that have the effect of nourishing blood and promoting blood circulation. The combination of the above components has a synergistic effect:

Anemia or qi and blood deficiency, traditional Chinese medicine theory believes that it is due to the weak spleen and stomach, and the reason why the peanut red coat can achieve the purpose of nourishing blood is because the peanut red coat can replenish the qi of the spleen and stomach, so that the spleen can be better transported and strengthened. The absorption of food can promote the hematopoietic function of the human body; Western medicine theory believes that peanut red coat can inhibit the dissolution of fibrin, increase the content of platelets, improve the quality of platelets, improve the defects of blood coagulation factors, strengthen the contraction function of capillaries, and promote bone marrow. Hematopoietic function, so as to achieve the purpose of replenishing blood;

The blood-enriching function of jujube is because the polysaccharides in jujube promote hematopoiesis. The key to hematopoietic regulation lies in the use of hematopoietic progenitor cells by hematopoietic stem cells, especially the hematopoietic growth factor receptors appear on the latter membrane. Polysaccharides are the effective components of jujube to promote hematopoiesis The mechanism of action is to indirectly stimulate the proliferation and differentiation of hematopoietic stem cells and hematopoietic progenitor cells by activating the body's hematopoietic regulatory system. Indirectly induce and activate macrophages, fibroblasts, lymphocytes, etc. in the hematopoietic microenvironment, or stimulate skeletal muscle tissue through indirect pathways in vivo, so that they secrete highly active erythroid hematopoietic regulatory factors, which regulate hematopoietic regulatory factors Proliferation and differentiation of hematopoietic stem cells and progenitor cells, promote erythroid hematopoiesis.

Donkey-hide gelatin has a significant promotion effect on red blood cells and hemoglobin in animals, and can promote the proliferation and differentiation of hematopoietic stem cells in the body. It can increase the number of white blood cells, enhance the hematopoietic function of the human body, and cooperate with the above-mentioned several raw materials to jointly promote the hematopoietic function of the body;

Saffron has the effect of invigorating blood circulation, dredging meridians, promoting qi and blood, making blood flow unimpeded, improving blood flow, and promoting the hematopoietic function of hematopoietic cells. Combined with the above-mentioned raw materials, it not only further promotes blood enrichment, but also the addition of wolfberry and saffron can eliminate the unpleasant smell of donkey-hide gelatin itself, making the chewable tablet taste better.

The improved method is as follows:

(1) Raw material pretreatment: After removing impurities from the peanut red coat, dry it at 50-60°C until its moisture content is 4-8%, and ultrafinely pulverize the dried peanut red coat to 500-1000 mesh to obtain red peanut powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum dry them for 4-12 hours under the condition of vacuum degree of 10-40Mpa, and ultrafinely grind the red dates after freeze-drying to 500-1000 mesh to obtain red dates pink;

Superfinely crush donkey-hide gelatin to 500-1000 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry for 4-12 hours under the condition of a vacuum degree of 10-40Mpa, and ultrafinely pulverize the freeze-vacuum-dried product to 500-1000 mesh to obtain wolfberry powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 40-50 parts of peanut red coat powder, 20-30 parts of red date powder, 5-12 parts of donkey-hide gelatin powder, 5 parts of wolfberry powder -15 parts, 1-10 parts of sucrose, 6-10 parts of milk powder, 2-4 parts of xylitol, 1-3 parts of gum arabic; add 90% ethanol as a wetting agent to the above materials, and keep stirring while adding, Until the soft material can be dispersed after being kneaded into a ball;

(4) Granulation: Put the kneaded material in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 4-8%, and dry them The particles passed through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 1-3 parts of magnesium stearate to the sieved granules, mix evenly, and then press the tablets with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 10-14 minutes with a dose of cobalt-60 radioactive source of 5-9kGy for sterilization.

Preferably, the parts by weight of each raw material are as follows: 45 parts of peanut red coat powder, 25 parts of red date powder, 8 parts of donkey-hide gelatin powder, 10 parts of wolfberry powder, 5 parts of sucrose, 7 parts of milk powder, 3 parts of xylitol, gum arabic 2 parts, 2 parts of magnesium stearate.

Another improvement is as follows, a method for making a chewable tablet with a blood-enriching effect, comprising the following steps:

(1) Raw material pretreatment: After removing impurities from the peanut red coat, dry it at 50-60°C until its moisture content is 4-8%, and ultrafinely pulverize the dried peanut red coat to 500-1000 mesh to obtain red peanut powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum dry them for 4-12 hours under the condition of vacuum degree of 10-40Mpa, and ultrafinely grind the red dates after freeze-drying to 500-1000 mesh to obtain red dates pink;

Superfinely crush donkey-hide gelatin to 500-1000 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry for 4-12 hours under the condition of a vacuum degree of 10-40Mpa, and ultrafinely pulverize the freeze-vacuum-dried product to 500-1000 mesh to obtain wolfberry powder;

Superfinely pulverize saffron to 500-1000 mesh to obtain saffron powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 40-50 parts of peanut red coat powder, 20-30 parts of red date powder, 5-12 parts of donkey-hide gelatin powder, 5 parts of wolfberry powder -15 parts, 0.1-3 parts of saffron powder, 1-10 parts of sucrose, 6-10 parts of milk powder, 2-4 parts of xylitol, 1-3 parts of gum arabic; add 90% ethanol as a humectant to the above materials , stirring continuously while adding, until the soft material can be dispersed after being kneaded into a ball;

(4) Granulation: Put the processed materials in step (3) into the granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 4-8%, and dry Good particles pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 1-3 parts of magnesium stearate to the sieved granules, mix evenly, and then press the tablets with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 10-14 minutes with a dose of cobalt-60 radioactive source of 5-9kGy for sterilization.

Preferably, the parts by weight of each raw material are as follows: 45 parts of peanut red coat powder, 25 parts of red date powder, 8 parts of donkey-hide gelatin powder, 10 parts of wolfberry powder, 1 part of saffron powder, 5 parts of sucrose, 7 parts of milk powder, xylitol 3 parts, 2 parts of gum arabic, 2 parts of magnesium stearate.

Preferably, the method for the preparation method of the chewable tablet with blood enriching effect, comprises the following steps:

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 55°C until its moisture content is 5%, and ultrafinely pulverize the dried peanut red coat to 600 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum-dry them for 8 hours under the condition of vacuum degree of 30Mpa, and ultrafinely grind the red dates after freeze-drying to 600 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 600 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 6 hours under the condition of a vacuum degree of 20Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 600 meshes to obtain wolfberry powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 45 parts of peanut red coat powder, 25 parts of red date powder, 6 parts of donkey-hide gelatin powder, 8 parts of wolfberry powder, 2 parts of sucrose, 6 parts of milk powder, 3 parts of xylitol, and 2 parts of gum arabic; add 90% ethanol as a humectant to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball;

(4) Granulation: Put the material kneaded in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 6%, and dry the granules Pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 2 parts of magnesium stearate to the sieved granules, mix evenly, and then compress the tablet with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 12 minutes under the dose of cobalt-60 radioactive source 8kGy for sterilization.

Preferably, the method for the preparation method of the chewable tablet with blood enriching effect, comprises the following steps:

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry at 55°C until its moisture content is 6%, and ultrafinely pulverize the dried peanut red coat to 6000 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum-dry them for 6 hours under the condition of vacuum degree of 20Mpa, and ultrafinely grind the red dates after freeze-drying to 600 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 600 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 6 hours under the condition of a vacuum degree of 20Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 600 meshes to obtain wolfberry powder;

Saffron is ultrafinely crushed to 600 mesh to obtain saffron powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 45 parts of peanut red powder, 25 parts of red date powder, 6 parts of donkey-hide gelatin powder, 8 parts of wolfberry powder, and 1 part of saffron powder , 3 parts of sucrose, 7 parts of milk powder, 3 parts of xylitol, and 2 parts of gum arabic; add 90% ethanol as a wetting agent to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball;

(4) Granulation: Put the processed materials in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 6%, and put the dried Granules pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 2 parts of magnesium stearate to the sieved granules, mix evenly, and then compress the tablet with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 12 minutes under the dose of cobalt-60 radioactive source 8kGy for sterilization.

The beneficial effect of the present invention is that the chewable tablet prepared by the above-mentioned method has a better effect of nourishing blood and is of great benefit to human health. By freeze-drying red dates in vacuum, compared with ordinary drying methods, it can effectively reduce In order to avoid the loss of nutrient components, the nutrient components of red dates are kept to the greatest extent, so that they can be retained and absorbed by the human body.

It has been clinically proven that the combination of peanuts and jujube can enhance the effect of nourishing blood and stopping bleeding, and has certain curative effects on spleen deficiency, anemia, thrombocytopenic purpura, and hemophilia.

The chewable tablet of the invention is crisp in texture, comfortable in mouthfeel, has no bad taste, is convenient to eat, retains active substances in various raw materials, and nourishes qi and blood of human body.

In addition, in the present invention, donkey-hide gelatin, wolfberry and saffron are added to the raw materials, which further enhances its blood-enriching effect, and the addition of the above-mentioned substances, especially the sweetness of wolfberry itself, also improves chewing The mouthfeel of the tablet increases its acceptance.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments, so that those skilled in the art can better understand the present invention, but the present invention is not limited thereby.

Example 1

The preparation method of the chewable tablet with blood enriching effect comprises the following steps:

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 55°C until its moisture content is 6%, and ultrafinely pulverize the dried peanut red coat to 600 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum-dry them for 6 hours under the condition of vacuum degree of 20Mpa, and ultrafinely grind the red dates after freeze-drying to 600 mesh to obtain red dates powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 45 parts of peanut red powder, 25 parts of red date powder, 15 parts of sucrose, 8 parts of milk powder, 3 parts of xylitol, Arabica 2 parts of glue; add 90% ethanol as a wetting agent to the above raw materials, and keep stirring while adding, until they can be dispersed after being kneaded into a ball;

(4) Granulation: Put the kneaded raw materials in step (3) into a swing granulator for granulation, and then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 6%. The dried granules are passed through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 2 parts of magnesium stearate to the sieved granules, mix evenly, and then press through a single tablet press to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 12 minutes under the dose of cobalt-60 radioactive source 8kGy for sterilization.

Observing the tablet, the results are as follows:

                                                 

stability

Take the tablet and place it in a constant temperature sealed airtight container, and place it at 35°C for 10 days at a relative humidity of about 90%, take samples on the 5th and 10th day, and accurately weigh the tablet before and after the test. Investigate the moisture absorption capacity of the test product;

As can be seen from the above table, sample 1 in the tablet of the present invention was placed for 5 days at 35°C under a relative humidity of about 90%, and its weight gain was 1.19%. After 10 days, the weight gain was 3.98%. %; It has good stability and strong moisture resistance;

In the tablet of the present invention, sample 2 was placed for 5 days at 35°C under the condition that the relative humidity was about 90%, and its weight gain was 1.97%. After 10 days, the weight gain was 4.98%; its stability was better, with Strong moisture resistance;

In the tablet of the present invention, sample 3 was placed for 5 days at 35°C under the condition that the relative humidity was about 90%, and its weight gain was 1.58%, and after 10 days of placement, the weight gain was 2.21%; its stability is better, there is Strong moisture resistance;

The chewable tablet of Example 1 was tested on human body with anemia, the dosage was twice a day, three tablets each time (1 gram per tablet), the test population was 50 women aged 45-55, and the other 50 women served as controls In the group, the hemoglobin content of 100 women was less than 110g/l, and the time was 30 days. The purpose of this test was to observe the increase of hemoglobin content and hematocrit in the subjects after taking chewable tablets;

Changes of hemoglobin content (g/l) between the control group and the test group

 

It can be seen from the above results that after taking the chewable tablet provided in this example, the subject's hemoglobin increased significantly, with an increase value of 27.8, which indicated that the chewable tablet provided in this example has better blood enriching effect.

Example 2

The preparation method of the chewable tablet with blood enriching effect comprises the following steps:

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 50°C until its moisture content is 4%, and ultrafinely pulverize the dried peanut red coat to 500 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the core of red dates, freeze and vacuum-dry them for 4 hours under the condition of vacuum degree of 10Mpa, and ultrafinely grind the red dates after freeze-drying to 500 mesh to obtain red dates powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 40 parts of peanut red powder, 20 parts of red date powder, 10 parts of sucrose, 6 parts of milk powder, 2 parts of xylitol, Arabica 1 part of glue; add 90% ethanol as a wetting agent to the above raw materials, and keep stirring while adding, until it can be dispersed after being kneaded into a ball;

(4) Granulation: Put the kneaded raw materials in step (3) into a granulator for granulation, and then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 4%. The particles passed through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 1 part of magnesium stearate to the sieved granules, mix evenly, and then compress the tablet with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated with a cobalt-60 radioactive source of 5kGy for 10 minutes to sterilize.

Example 3

The preparation method of the chewable tablet with blood enriching effect comprises the following steps:

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 60°C until its moisture content is 8%, and ultrafinely pulverize the dried peanut red coat to 1000 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum-dry them for 12 hours under the condition of vacuum degree of 40Mpa, and ultrafinely grind the red dates after freeze-drying to 000 mesh to obtain red dates powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 50 parts of peanut red powder, 30 parts of red date powder, 20 parts of sucrose, 10 parts of milk powder, 4 parts of xylitol, Arabica 3 parts of glue; add 90% ethanol as a wetting agent to the above raw materials, and keep stirring while adding, until they can be dispersed after being kneaded into a ball;

(4) Granulation: Put the kneaded raw materials in step (3) into a granulator for granulation, and then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 8%. The particles passed through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 3 parts of magnesium stearate to the sieved granules, mix evenly, and then press through a single tablet press to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 14 minutes to sterilize under the dose of cobalt-60 radioactive source 9kGy.

Example 4

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 55°C until its moisture content is 6%, and ultrafinely pulverize the dried peanut red coat to 600 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum-dry them for 6 hours under the condition of vacuum degree of 20Mpa, and ultrafinely grind the red dates after freeze-drying to 600 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 600 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 6 hours under the condition of a vacuum degree of 20Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 600 meshes to obtain wolfberry powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 45 parts of peanut red coat powder, 25 parts of red date powder, 6 parts of donkey-hide gelatin powder, 8 parts of wolfberry powder, 4 parts of sucrose, 8 parts of milk powder, 3 parts of xylitol, and 2 parts of gum arabic; add 90% ethanol as a humectant to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball;

(4) Granulation: Put the material kneaded in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 6%, and dry the granules Pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 2 parts of magnesium stearate to the sieved granules, mix evenly, and then press through a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 12 minutes under the dose of cobalt-60 radioactive source 8kGy for sterilization.

Example 5

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 55°C until its moisture content is 6%, and ultrafinely pulverize the dried peanut red coat to 600 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum-dry them for 6 hours under the condition of vacuum degree of 20Mpa, and ultrafinely grind the red dates after freeze-drying to 600 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 600 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 6 hours under the condition of a vacuum degree of 20Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 600 meshes to obtain wolfberry powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 45 parts of peanut red coat powder, 25 parts of red date powder, 8 parts of donkey-hide gelatin powder, 10 parts of wolfberry powder, 5 parts of sucrose, 7 parts of milk powder, 3 parts of xylitol, and 2 parts of gum arabic; add 90% ethanol as a humectant to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball;

(4) Granulation: Put the material kneaded in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 6%, and dry the granules Pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 2 parts of magnesium stearate to the sieved granules, mix evenly, and then press through a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 12 minutes under the dose of cobalt-60 radioactive source 8kGy for sterilization.

The chewable tablet of Example 5 was tested on human body with anemia, the dosage was two times a day, three tablets each time (1 gram per tablet), the test population was 50 women aged 45-55, and the other 50 women served as controls In the group, the hemoglobin content of 100 women was less than 110g/l, and the time was 30 days. The purpose of this test was to observe the increase of hemoglobin content and hematocrit in the subjects after taking chewable tablets;

Changes of hemoglobin content (g/l) between the control group and the test group

 

After the women in the test group ate the chewable tablets for 30 days, the average increase in hemoglobin was 35.9, which shows that the above embodiments have a strong blood-enriching effect.

Example 6

The method for the preparation method of the chewable tablet with blood enriching effect, comprises the following steps:

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 55°C until its moisture content is 5%, and ultrafinely pulverize the dried peanut red coat to 600 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum-dry them for 8 hours under the condition of vacuum degree of 30Mpa, and ultrafinely grind the red dates after freeze-drying to 600 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 600 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 6 hours under the condition of a vacuum degree of 20Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 600 meshes to obtain wolfberry powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 45 parts of peanut red coat powder, 25 parts of red date powder, 6 parts of donkey-hide gelatin powder, 8 parts of wolfberry powder, 2 parts of sucrose, 6 parts of milk powder, 3 parts of xylitol, and 2 parts of gum arabic; add 90% ethanol as a humectant to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball;

(4) Granulation: Put the material kneaded in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 6%, and dry the granules Pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 2 parts of magnesium stearate to the sieved granules, mix evenly, and then compress the tablet with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 12 minutes under the dose of cobalt-60 radioactive source 8kGy for sterilization.

Example 7

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 50°C until its moisture content is 4%, and ultrafinely pulverize the dried peanut red coat to 500 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the core of red dates, freeze and vacuum-dry them for 4 hours under the condition of vacuum degree of 10Mpa, and ultrafinely grind the red dates after freeze-drying to 500 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 500 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 4 hours under the condition of a vacuum degree of 10Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 500 meshes to obtain wolfberry powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 40 parts of peanut red coat powder, 20 parts of red date powder, 5 parts of donkey-hide gelatin powder, 5 parts of wolfberry powder, 1 part of sucrose, 6 parts of milk powder, 2 parts of xylitol, and 1 part of gum arabic; add 90% ethanol as a humectant to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball;

(4) Granulation: Put the material kneaded in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 4%, and dry the granules Pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 1 part of magnesium stearate to the sieved granules, mix evenly, and then compress the tablet with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 10 minutes at the dose of cobalt-60 radioactive source 5kGy for sterilization.

Example 8

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 60°C until its moisture content is 8%, and ultrafinely pulverize the dried peanut red coat to 1000 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the core of red dates, freeze and vacuum-dry them for 12 hours under the condition of vacuum degree of 40Mpa, and superfine the freeze-dried red dates to 1000 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 1000 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 12 hours under the condition of a vacuum degree of 40Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 1000 meshes to obtain wolfberry powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 50 parts of peanut red coat powder, 30 parts of red date powder, 12 parts of donkey-hide gelatin powder, 15 parts of wolfberry powder, 10 parts of sucrose, 10 parts of milk powder, 4 parts of xylitol, and 3 parts of gum arabic; add 90% ethanol as a humectant to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball;

(4) Granulation: Put the material kneaded in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 8%, and dry the granules Pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 3 parts of magnesium stearate to the sieved granules, mix evenly, and then press the tablets with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are put into cobalt-60 equipment for sterilization, and the sterilization conditions are: irradiated for 14 minutes to sterilize under the dose of cobalt-60 radioactive source 9kGy.

Example 9

The method for the preparation method of the chewable tablet with blood enriching effect, comprises the following steps:

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 55°C until its moisture content is 6%, and ultrafinely pulverize the dried peanut red coat to 600 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum-dry them for 6 hours under the condition of vacuum degree of 20Mpa, and ultrafinely grind the red dates after freeze-drying to 600 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 600 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 6 hours under the condition of a vacuum degree of 20Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 600 meshes to obtain wolfberry powder;

Saffron is ultrafinely crushed to 600 mesh to obtain saffron powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 45 parts of peanut red powder, 25 parts of red date powder, 6 parts of donkey-hide gelatin powder, 8 parts of wolfberry powder, and 1 part of saffron powder , 3 parts of sucrose, 7 parts of milk powder, 3 parts of xylitol, and 2 parts of gum arabic; add 90% ethanol as a wetting agent to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball;

(4) Granulation: Put the processed materials in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 6%, and put the dried Granules pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 2 parts of magnesium stearate to the sieved granules, mix evenly, and then compress the tablet with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 12 minutes under the dose of cobalt-60 radioactive source 8kGy for sterilization.

There are saffron components in the chewable tablets prepared in the following examples, and saffron has the effect of promoting blood circulation. The chewable tablets with saffron components should be noted when chewing: women should not take them during menstruation, pregnancy and functional bleeding.

The chewable tablet of Example 9 was tested on human body with anemia, the dosage was two times a day, three tablets each time (1 g per tablet), the test population was 50 women aged 45-55, and the other 50 women served as controls In the group, the hemoglobin content of 100 women was less than 110g/l, and the time was 30 days. The purpose of this test was to observe the increase of hemoglobin content and hematocrit in the subjects after taking chewable tablets;

Changes of hemoglobin content (g/l) between the control group and the test group

 

Example 10

The method for the preparation method of the chewable tablet with blood enriching effect, comprises the following steps:

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 50°C until its moisture content is 4%, and ultrafinely pulverize the dried peanut red coat to 500 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the core of red dates, freeze and vacuum-dry them for 4 hours under the condition of vacuum degree of 10Mpa, and ultrafinely grind the red dates after freeze-drying to 500 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 500 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 4 hours under the condition of a vacuum degree of 10Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 500 meshes to obtain wolfberry powder;

Saffron is ultrafinely crushed to 500 mesh to obtain saffron powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 40 parts of peanut red powder, 20 parts of red date powder, 5 parts of donkey-hide gelatin powder, 5 parts of wolfberry powder, and 0.5 parts of saffron powder , 1 part of sucrose, 6 parts of milk powder, 2 parts of xylitol, and 1 part of gum arabic; add 90% ethanol as a wetting agent to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball;

(4) Granulation: Put the processed materials in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 4%, and dry the granules Pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 1 part of magnesium stearate to the sieved granules, mix evenly, and then compress the tablet with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 10 minutes at the dose of cobalt-60 radioactive source 5kGy for sterilization.

Example 11

The method for the preparation method of the chewable tablet with blood enriching effect, comprises the following steps:

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 60°C until its moisture content is 8%, and ultrafinely pulverize the dried peanut red coat to 1000 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the core of red dates, freeze and vacuum-dry them for 12 hours under the condition of vacuum degree of 40Mpa, and superfine the freeze-dried red dates to 1000 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 1000 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 12 hours under the condition of a vacuum degree of 40Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 1000 meshes to obtain wolfberry powder;

Superfinely pulverize saffron to 1000 mesh to obtain saffron powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 50 parts of peanut red powder, 30 parts of red date powder, 12 parts of donkey-hide gelatin powder, 15 parts of wolfberry powder, and 3 parts of saffron powder 10 parts of sucrose, 10 parts of milk powder, 4 parts of xylitol, and 3 parts of gum arabic; add 90% ethanol as a wetting agent to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball;

(4) Granulation: Put the processed materials in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 8%, and dry the granules Pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 3 parts of magnesium stearate to the sieved granules, mix evenly, and then press the tablets with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are put into cobalt-60 equipment for sterilization, and the sterilization conditions are: irradiated for 14 minutes to sterilize under the dose of cobalt-60 radioactive source 9kGy.

Example 12

(1) Raw material pretreatment: remove impurities from the peanut red coat, dry it at 50°C until its moisture content is 4%, and ultrafinely pulverize the dried peanut red coat to 500 mesh to obtain peanut red coat powder;

(2) Superfine crushing of red dates: remove the core of red dates, freeze and vacuum-dry them for 4 hours under the condition of vacuum degree of 10Mpa, and ultrafinely grind the red dates after freeze-drying to 500 mesh to obtain red dates powder;

Superfinely pulverize donkey-hide gelatin to 500 mesh to obtain donkey-hide gelatin powder;

Freeze and vacuum-dry the wolfberry, and freeze and vacuum-dry it for 4 hours under the condition of a vacuum degree of 10Mpa, and ultrafinely pulverize the freeze-vacuum dried product to 500 meshes to obtain wolfberry powder;

(3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 40 parts of peanut red coat powder, 20 parts of red date powder, 5 parts of donkey-hide gelatin powder, 5 parts of wolfberry powder, 1 part of sucrose, 6 parts of milk powder, 2 parts of xylitol, 2 parts of active yeast, and 1 part of gum arabic; add 90% ethanol as a wetting agent to the above materials, and keep stirring while adding, until the soft material can be dispersed after being kneaded into a ball;

(4) Granulation: Put the material kneaded in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 4%, and dry the granules Pass through a 14-mesh sieve to obtain granular products;

(5) Tablet compression: Add 1 part of magnesium stearate to the sieved granules, mix evenly, and then compress the tablet with a tablet machine to obtain tablets;

(6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 10 minutes at the dose of cobalt-60 radioactive source 5kGy for sterilization.

Because donkey-hide gelatin is not easily digested, it is also difficult for the human body to absorb, because the addition of active yeast helps the body to absorb donkey-hide gelatin.

Claims (3)

1. The preparation method of the chewable tablet with blood enriching effect, comprises the following steps: (1) Raw material pretreatment: After removing impurities from the peanut red coat, dry it at 50-60°C until its moisture content is 4-8%, and ultrafinely pulverize the dried peanut red coat to 500-1000 mesh to obtain red peanut powder; (2) Superfine crushing of red dates: remove the pits of red dates, freeze and vacuum dry them for 4-12 hours under the condition of vacuum degree of 10-40Mpa, and ultrafinely grind the red dates after freeze-drying to 500-1000 meshes to obtain red dates pink; Superfinely crush donkey-hide gelatin to 500-1000 mesh to obtain donkey-hide gelatin powder; Freeze and vacuum-dry wolfberry, and freeze and vacuum-dry for 4-12 hours under the condition of vacuum degree of 10-40Mpa, and ultrafinely pulverize the freeze-dried product to 500-1000 mesh to obtain wolfberry powder; Superfinely pulverize saffron to 500-1000 mesh to obtain saffron powder; (3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 45 parts of peanut red powder, 25 parts of red date powder, 8 parts of donkey-hide gelatin powder, 10 parts of wolfberry powder, and 1 part of saffron powder , 5 parts of sucrose, 7 parts of milk powder, 3 parts of xylitol, and 2 parts of gum arabic; add 90% ethanol as a wetting agent to the above materials, and keep stirring while adding, until the soft materials can be dispersed after kneading into a ball; (4) Granulation: Put the processed materials in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 4-8%, and dry them The granules are passed through a 14-mesh sieve to obtain granular products; (5) Tablet compression: Add 2 parts of magnesium stearate to the sieved granules, mix evenly, and then compress the tablet with a tablet machine to obtain tablets; (6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 10 to 14 minutes at a dose of 5 to 9 kGy of cobalt-60 radioactive source to sterilize. 2. The preparation method of the chewable tablet with blood enriching effect comprises the following steps: (1) Raw material pretreatment: remove impurities from the peanut red coat, dry at 55°C until its moisture content is 5%, and ultrafinely pulverize the dried peanut red coat to 600 mesh to obtain peanut red coat powder; (2) Superfine crushing of red dates: remove the core of red dates, freeze and vacuum-dry them for 8 hours under the condition of vacuum degree of 30Mpa, and ultrafinely grind the red dates after freeze-drying to 600 mesh to obtain red dates powder; Superfinely pulverize donkey-hide gelatin to 600 mesh to obtain donkey-hide gelatin powder; Freeze and vacuum-dry wolfberry, and freeze and vacuum-dry for 6 hours under the condition of vacuum degree of 20Mpa, and ultrafinely pulverize the freeze-dried product to 600 mesh to obtain wolfberry powder; (3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 45 parts of peanut red powder, 25 parts of red date powder, 6 parts of donkey-hide gelatin powder, 8 parts of wolfberry powder, 2 parts of sucrose, 6 parts of milk powder, 3 parts of xylitol, and 2 parts of gum arabic; add 90% ethanol as a wetting agent to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball; (4) Granulation: Put the material kneaded in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 6%, and dry the granules Cross 14 mesh sieves to get granular products; (5) Tablet compression: add 2 parts of magnesium stearate to the sieved granules, mix evenly, and then press the tablets with a tablet machine to obtain tablets; (6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 12 minutes under the dose of cobalt-60 radioactive source 8kGy for sterilization. 3. The preparation method of the chewable tablet with blood-enriching effect comprises the following steps: (1) Raw material pretreatment: remove impurities from the peanut red coat, dry at 55°C until its moisture content is 6%, and ultrafinely pulverize the dried peanut red coat to 6000 mesh to obtain peanut red coat powder; (2) Superfine crushing of red dates: remove the core of red dates, freeze and vacuum-dry them for 6 hours under the condition of vacuum degree of 20Mpa, and ultrafinely grind the red dates after freeze-drying to 600 mesh to obtain red dates powder; Superfinely pulverize donkey-hide gelatin to 600 mesh to obtain donkey-hide gelatin powder; Freeze and vacuum-dry wolfberry, and freeze and vacuum-dry for 6 hours under the condition of vacuum degree of 20Mpa, and ultrafinely pulverize the freeze-dried product to 600 mesh to obtain wolfberry powder; Superfinely pulverize saffron to 600 mesh to obtain saffron powder; (3) Preparation of soft materials: Stir the materials evenly, and mix according to the following parts by weight: 45 parts of peanut red powder, 25 parts of red date powder, 6 parts of donkey-hide gelatin powder, 8 parts of wolfberry powder, and 1 part of saffron powder , 3 parts of sucrose, 7 parts of milk powder, 3 parts of xylitol, and 2 parts of gum arabic; add 90% ethanol as a wetting agent to the above materials, and keep stirring while adding, until the soft materials can be dispersed after being kneaded into a ball; (4) Granulation: Put the processed materials in step (3) into a granulator for granulation, then place the granulated granules in a low-temperature vacuum drying oven to dry to a moisture content of 6%, and dry the granules Cross 14 mesh sieves to get granular products; (5) Tablet compression: add 2 parts of magnesium stearate to the sieved granules, mix evenly, and then press the tablets with a tablet machine to obtain tablets; (6) Packaging and sterilization: The tablets prepared by packaging are sterilized in cobalt-60 equipment. The sterilization conditions are: irradiated for 12 minutes under the dose of cobalt-60 radioactive source 8kGy for sterilization.