CN103341145B - Traditional Chinese medicine for treating psoriasis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating psoriasis and preparation method thereof Download PDFInfo
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- CN103341145B CN103341145B CN201310297301.0A CN201310297301A CN103341145B CN 103341145 B CN103341145 B CN 103341145B CN 201310297301 A CN201310297301 A CN 201310297301A CN 103341145 B CN103341145 B CN 103341145B
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Abstract
The invention belongs to the technical field of medicines and in particular relates to a traditional Chinese medicine for treating psoriasis and a preparation method thereof. The traditional Chinese medicine for treating psoriasis is prepared from the following bulk pharmaceutical chemicals: rehmannia root, glossy privet fruit, eclipta, medlar, radix ophiopogonis, lalang grass rhizome, lithospermum, honeysuckle, fructus forsythiae, red paeony root, moutan bark, isatis root, dandelion, Chinese violet, fructus kochiae, cortex dictamni, sophora flavescens, zaocys dhumnade, cicada slough, rhizoma smilacis glabrae, coix seed, raw fructus aurantii, radix glehniae, lily, folium isatidis, sophora flower, dahurian patrinia herb, indigo naturalis, cornu bubali powder, salviae miltiorrhizae, dried ginger, fineleaf schizonepeta herb, divaricate saposhnikovia root, Chinese angelica, raw white paeony root and golden cypress. The traditional Chinese medicine for treating psoriasis has the effects of nourishing Yin and moistening dryness, nourishing blood, removing heat to cool blood as well as dispelling wind and arresting itching and is used for treating blood dryness type, blood deficiency type and blood fever type psoriasis caused by deficiency of kidney yin.
Description
Technical field
The invention belongs to medical art, be specifically related to one and treat psoriatic Chinese medicine and preparation method thereof.
Background technology
Psoriasis is commonly called as " psoriasis ", and be a kind of common refractory skin with chronic easy of characteristic skin lesion, old children irrespective of sex all can be ill.Patient gets more and more in recent years.Psoriasis with heredity, immunity, infect, physics, spirit, life, the factors such as environment be relevant.The traditional Chinese medical science belongs to " white defect ", " chronic eczema " category.Morbidity is common in person between twenty and fifty, and skin lesion stretches side, tail sacrum portion based on scalp, trunk and extremity.
Each psoriasis pustulosa case, the overwhelming majority adopts hormones long-term treatment, is difficult to thoroughly cure, and easy recurrent exerbation or the state of an illness increase the weight of gradually.
Treatment psoriasis commonly uses the medicine of dispelling wind for relieving itching, and although the method that these medicines just take stopgap measures, temporarily onset, easily recurs.
Patent CN103110851A discloses one and treats psoriatic Chinese medicine composition, primarily of Herba Schizonepetae, Radix Saposhnikoviae, Pericarpium Zanthoxyli, Radix Gentianae, Periostracum Cicadae, Cortex Dictamni, the Fructus Kochiae, Semen Coicis, Zaocys, Cortex Moutan, Radix Ophiopogonis, Radix Paeoniae Rubra, Fructus Forsythiae, Radix Salviae Miltiorrhizae, Herba Taraxaci, Semen Persicae, Cortex Phellodendri, Rhizoma Polygoni Cuspidati composition, this invention Chinese medicine composition effectively can alleviate the erythra symptom caused by psoriasis, and there is effect that is antipruritic, pain relieving, having good therapeutical effect to psoriasis, is the psoriatic Chinese medicine composition of a kind for the treatment of safe and effective and without any side effects.But the Chinese medicine of this invention needs to decoct, and dosage is large, the medicine that the Chinese medicine great majority of this invention in addition dispel the wind for heat-clearing and toxic substances removing, taste is more bitter, takes bitter to the taste, and patient is not easy acceptance.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides one and treating psoriatic Chinese medicine composition and preparation method thereof.
The present invention is realized by following technical scheme:
One treats psoriatic Chinese medicine, is made up of the crude drug of following weight portion:
Radix Rehmanniae 80-120 part, Fructus Ligustri Lucidi 10-20 part, Herba Ecliptae 10-20 part, Fructus Lycii 10-20 part, Radix Ophiopogonis 15-25 part, Rhizoma Imperatae 20-40 part, Radix Arnebiae (Radix Lithospermi) 20-40 part, Flos Lonicerae 15-25 part, Fructus Forsythiae 15-25 part, Radix Paeoniae Rubra 15-25 part, Cortex Moutan 15-25 part, Radix Isatidis 20-40 part, Herba Taraxaci 15-25 part, Herba Violae 15-25 part, Fructus Kochiae 20-40 part, Cortex Dictamni 20-40 part, Radix Sophorae Flavescentis 45-55 part, Zaocys 5-15 part, Periostracum Cicadae 5-15 part, Rhizoma Smilacis Glabrae 20-40 part, Semen Coicis 20-40 part, raw Fructus Aurantii 15-25 part, Radix Glehniae 80-120 part, Bulbus Lilii 80-120 part, Folium Isatidis 20-40 part, Flos Sophorae 45-55 part, Herba Patriniae 15-25 part, Indigo Naturalis 45-55 part, Cornu Bubali powder 45-55 part, Radix Salviae Miltiorrhizae 10-20 part, Rhizoma Zingiberis 3-7 part, Herba Schizonepetae 3-7 part, Radix Saposhnikoviae 3-7 part, Radix Angelicae Sinensis 3-7 part, Radix Paeoniae Alba 3-7 part, Cortex Phellodendri 3-7 part.
Preferably, the psoriatic Chinese medicine of above-mentioned treatment, be made up of the crude drug of following weight portion:
Radix Rehmanniae 90-110 part, Fructus Ligustri Lucidi 13-17 part, Herba Ecliptae 13-17 part, Fructus Lycii 13-17 part, Radix Ophiopogonis 18-22 part, Rhizoma Imperatae 25-35 part, Radix Arnebiae (Radix Lithospermi) 25-35 part, Flos Lonicerae 18-22 part, Fructus Forsythiae 18-22 part, Radix Paeoniae Rubra 18-22 part, Cortex Moutan 18-22 part, Radix Isatidis 25-35 part, Herba Taraxaci 18-22 part, Herba Violae 18-22 part, Fructus Kochiae 25-35 part, Cortex Dictamni 25-35 part, Radix Sophorae Flavescentis 45-55 part, Zaocys 8-12 part, Periostracum Cicadae 8-12 part, Rhizoma Smilacis Glabrae 25-35 part, Semen Coicis 25-35 part, raw Fructus Aurantii 18-22 part, Radix Glehniae 90-110 part, Bulbus Lilii 90-110 part, Folium Isatidis 25-35 part, Flos Sophorae 45-55 part, Herba Patriniae 18-22 part, Indigo Naturalis 45-55 part, Cornu Bubali powder 45-55 part, Radix Salviae Miltiorrhizae 13-17 part, Rhizoma Zingiberis 4-6 part, Herba Schizonepetae 4-6 part, Radix Saposhnikoviae 4-6 part, Radix Angelicae Sinensis 4-6 part, Radix Paeoniae Alba 4-6 part, Cortex Phellodendri 4-6 part.
Preferred, the psoriatic Chinese medicine of above-mentioned treatment, be made up of the crude drug of following weight portion:
100 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 15 parts, Herba Ecliptae 15 parts, Fructus Lycii 15 parts, Radix Ophiopogonis 20 parts, Rhizoma Imperatae 30 parts, Radix Arnebiae (Radix Lithospermi) 30 parts, Flos Lonicerae 20 parts, Fructus Forsythiae 20 parts, Radix Paeoniae Rubra 20 parts, Cortex Moutan 20 parts, Radix Isatidis 30 parts, Herba Taraxaci 20 parts, Herba Violae 20 parts, the Fructus Kochiae 30 parts, Cortex Dictamni 30 parts, Radix Sophorae Flavescentis 50 parts, Zaocys 10 parts, Periostracum Cicadae 10 parts, Rhizoma Smilacis Glabrae 30 parts, Semen Coicis 30 parts, raw Fructus Aurantii 20 parts, Radix Glehniae 100 parts, Bulbus Lilii 100 parts, Folium Isatidis 30 parts, 50 parts, Flos Sophorae, Herba Patriniae 20 parts, Indigo Naturalis 50 parts, Cornu Bubali powder 50 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Zingiberis 5 parts, Herba Schizonepetae 5 parts, Radix Saposhnikoviae 5 parts, Radix Angelicae Sinensis 5 parts, Radix Paeoniae Alba 5 parts, Cortex Phellodendri 5 parts.
The present invention treats each crude drug of psoriatic Chinese medicine and is pharmacopeia or the kind described in Chinese materia medica textbook.
In above composition of the present invention, the weight of each taste medicine calculates, if in grams, as made preparation, then because varying in size of preparation can be made into 100-1000 agent with crude drug.Described 100-1000 agent refers to the dosage form of unit dose, as tablet 100-1000 sheet, and capsule 100-1000 grain, granule l00-1000 part, oral liquid l00-l000ml, unguentum l00-l000 part, pill 10-1000 ball etc.
More than composition is by weight as proportioning, can increase according to corresponding proportion when producing or reduce, as large-scale production can kilogram being raw material weight unit, or in units of ton, small-scale production also can be in grams, weight can increase or reduce, but the constant rate of weight proportion between each composition.
The psoriatic Chinese medicine of above-mentioned treatment, the dosage form of described Chinese medicine is oral formulations.These oral formulations dosage forms are selected from: tablet, capsule, oral liquid, suck agent, granule, pill, powder, preferably capsule and tablet.
The psoriatic Chinese medicine for the treatment of of the present invention, can be raw material of Chinese medicine medical material by above-mentioned formula is formed through to extract or other modes are processed, make active Chinese drug component material, subsequently, with this active Chinese drug component material for raw material, add medicine acceptable carrier when needing, make according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can be obtained by the common raw material of Chinese medicine medical material that extracts, also can obtain by other means, as: by pulverizing, squeezing, grind, sieve, the material that method obtains, these active substances can be extractum form such as percolation, extraction, water extraction, alcohol extraction, ester carry, chromatography, can be dry extract also can be fluid extract, need to determine to make different concentration according to the difference of preparation.
The present invention treats psoriatic Chinese medicine, and its pharmaceutically active substance is through that to extract processing obtained, as processed with following methods:
Above medicine is pulverized, and incapsulates,
Or
Above medicine is pulverized or through decocting in water, is obtained water extract, be condensed into cream, with this clear paste for raw material, add medicine acceptable carrier when needing, make according to the routine techniques of galenic pharmacy.
Medicine acceptable carrier comprises the diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant etc. of pharmaceutical field routine.These medicine acceptable carriers are selected from: Mel, refined honey, mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, tie up main plain E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, polysorbate60-80, span-80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, fine jade, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preferably, the psoriatic Chinese medicine of above-mentioned treatment, described active Chinese drug component substances preparation method is:
A () Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Semen Coicis, raw Fructus Aurantii, Flos Sophorae, Indigo Naturalis, Cornu Bubali powder, Cortex Phellodendri are pulverized as superfine powder, superfine powder particle size range 5-45 μm, obtains fine drug powder;
B the Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Glehniae, Bulbus Lilii, Folium Isatidis, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Zingiberis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Radix Paeoniae Alba are decocted with water 2 times by (), add 8 times of water of medical material weight for the first time, decoct 1.5 hours, second time adds medical material weight 6 times of water, decoct 1 hour, merge decoction liquor, filter, it is 1.12 ~ 1.19 that filtrate is concentrated into relative density; Then adding ethanol makes alcohol content be 80%, leave standstill after 8-10 hour and filter, filtrate 55-60 DEG C concentrating under reduced pressure, is concentrated into the clear paste that relative density is 1.20-1.30, and clear paste is 180-200 DEG C in spray dryer inlet temperature, outlet temperature is 70-90 DEG C, under moisture less than 8% condition, carry out spraying dry, the granule that spraying dry obtains is pulverized, cross 80 mesh sieves, obtain drug spray xeraphium;
C (), by fine drug powder obtained for step (a) and the obtained drug spray xeraphium of step (b), mix homogeneously, obtains active Chinese drug component material of the present invention.
Chinese medicine preparation of the present invention, when making medicament, the medicament of unit dose can contain active Chinese drug component material of the present invention 0.1 ~ l000mg, and all the other are pharmaceutically acceptable carrier.Pharmaceutically acceptable carrier can be the 0.01-99.9% of total formulation weight amount by weight.
Pharmaceutical preparation of the present invention is in use according to the situation determination usage and dosage of patient.Instructions of taking is taken to the ill because of the body constitution situation of patient, as day takes 1-4 time, and each 1-10 grain/sheet.
The most preferred formula of the present invention and preparation method row are in embodiments of the present invention.
The psoriatic Chinese medicine for the treatment of of the present invention, have nourshing Yin and drynsessmoistening prescriptionly to nourish blood, effect of clearing away heat and cooling blood, dispelling wind for relieving itching, for the blood dry blood deficiency blood-heat type psoriasis that deficiency of the kidney yin causes.
Take points for attention: 1. anemia of pregnant woman prohibits clothes, the careful clothes of child.2. weak, the careful clothes of Chronic gastrointestinal disorders patient.3. allergic constitution person is cautious use of.4. period in a medicine avoids ichthyophagy, shrimp, beef and mutton, gives up alcohol and pungent stimulation food.
Inventor is by the clinical observation in more than 10 years, and a large amount of psoriatics about 97% is the dry blood-heat type of blood, and namely the psoriatic of 97% belongs to the indication scope that the present invention treats psoriatic Chinese medicine, can apply separately the present invention and treat psoriatic Chinese medicine.Have about 1% for the scorching hot septicopyemia type that transforms into of pyretic toxicity, primary disease is in a bad way, and needs oral the present invention to treat psoriatic Chinese medicine use in conjunction anti-infective Drug therapy.2% is also had to be psoriasis inveterata, lesions of patients place is dark red, and skin lesion is large lamellar, and cortex is thick, matter is as leather, on cover a small amount of white scales, skin is itched and is not weighed, this kind of psoriatic, may with long-term outer to be coated with multiple antipruritic relevant, treat this kind of psoriasis, need the present invention to treat psoriatic Chinese medicine use in conjunction immunoregulation medicament, slowly nurse one's health.
The prescription theory of Chinese medical science basis that the present invention treats psoriatic Chinese medicine is:
(1) the kidney being a ZANG-organ containing both water and fire, kidney is resided Kidney-Yin kidney-Yang, be the whole body root of YIN and YANG this, be the cradle of the vital organs of the human body.Kidney yin is the cloudy liquid of human body basis, and non-this of the moon of the vital organs of the human body can not nourish.The negative and positive virtual loss of kidney can involve the five internal organs, and the five internal organs are also hindered " thoroughly must and kidney ", and the psoriasis course of disease is long, recurrent exerbation, and xerosis cutis does not heal all the year round, the kidney usually involved in chronic disease, treatment psoriasis must ask with this, start with from conditioning deficiency of the kidney yin.
(2) kidney promoting blood generates, kidney storing essence, the raw marrow of essence, and marrow hemopoietic, kidney essense can be changed and be blood, participates in the generation of blood, therefore has saying of " source of blood being kidney ".Psoriatic clinical manifestation, is mainly blood dry, and starting with from conditioning kidney yin to obtain good effect, only has balance kidney yin kidney yang, could stop psoriatic recurrent exerbation.
(3) kidney qi forked rubbing, kidney yin and kidney yang are the basic of other internal organs negative and positive of whole body, have promotion and regulating action to internal organs QI and blood.Psoriatic clinical manifestation is dry based on blood, although relevant with each internal organs, principal element is deficiency of the kidney yin.The present invention treats the compatibility of psoriatic Chinese medicine, based on YIN nourishing, seeks the combination of the best Yin-nourishing drug Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Radix Glehniae, Bulbus Lilii; Again because of Psoriasis place, what hands touched has burning sensation, and skin lesion place skin bright red, there is resembling of heat, therefore be aided with the product Flos Lonicerae of clearing away heat and cooling blood, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Flos Sophorae, Indigo Naturalis, Rheum alexandrae Batal. cypress, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Folium Isatidis, Herba Patriniae; Pyretic toxicity is strongly fragrant not to be understood for a long time, then easily consume impairment of YIN blood, hematogenous blockage, blood-stasis internal-depression, causes failure of skin and muscle to be nourished, is " outer disease enters network ", " prolonged illness becomes the stasis of blood ", therefore needs with Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra nourshing blood and promoting blood circulation removing heat from blood; Blood-deficiency and wind-dry, therefore psoriasis is itched more, skin falls to consider to be worth doing a lot of, therefore adds Herba Schizonepetae, Radix Saposhnikoviae, horn powder dispelling wind for relieving itching; The thing of YIN nourishing hinders stomach more, uses imapirment of the spleen and stomach for a long time, therefore adds the medicine Semen Coicis of drying damp and strengthening spleen stomach function regulating, raw Fructus Aurantii, Rhizoma Zingiberis.
According to the feature of psoriasis recurrent exerbation, formulate and effect a permanent cure as Therapeutic Principle with nourshing Yin and drynsessmoistening prescription nourishing blood, implied meaning " strengthening renal yin to inhibit predominant yang, with sunlight processed ".
Beneficial effect of the present invention is
(1) the invention provides the psoriatic Chinese medicine of a kind for the treatment of newly, meet clinical needs.
(2) the present invention treat psoriatic Chinese medicine be used for treat psoriasis, instant effect, short treating period, cure rate is high, and relapse rate is low, and untoward reaction is few.Cure 158 examples oral 1 course for the treatment of, a course cure rate 24.31%; Cure 204 examples oral 2 courses for the treatment of, 2 course cure rates 31.38%; Cure 172 examples oral 3 courses for the treatment of, 3 course cure rates 26.46%; Oral 3 courses for the treatment of effective 105 are routine, oral 3 ineffective courses 11 example.The follow-up of patients cured 3 years, recurs 4 people, relapse rate 0.75%.Total effective rate 98.31%, cure rate 82.16%, obvious effective rate 16.15%, inefficiency 1.69%.A routine untoward reaction is had no in 650 routine patients.
(3) the psoriasis state of an illness is obstinate, and the course of disease is long, needs Long-term taking medicine, conventional decoction in tcm clinical practice at present, patient need boil medicine every year, cumbersome, and many heat and toxic materials clearing away medicine inside medicine, mouthfeel is poor, summer not easily stores, and psoriatic for treatment medicine is prepared into capsule or tablet by the present invention after extracting processing, masks the bad smell of medicine, only need to eat several, drug administration and storage are conveniently at every turn; Capsule or tablet volume little, easily carry and store.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1 the present invention treats the preparation of psoriatic Chinese medicine capsules
Radix Rehmanniae 100g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Fructus Lycii 15g, Radix Ophiopogonis 20g, Rhizoma Imperatae 30g, Radix Arnebiae (Radix Lithospermi) 30g, Flos Lonicerae 20g, Fructus Forsythiae 20g, Radix Paeoniae Rubra 20g, Cortex Moutan 20g, Radix Isatidis 30g, Herba Taraxaci 20g, Herba Violae 20g, Fructus Kochiae 30g, Cortex Dictamni 30g, Radix Sophorae Flavescentis 50g, Zaocys 10g, Periostracum Cicadae 10g, Rhizoma Smilacis Glabrae 30g, Semen Coicis 30g, raw Fructus Aurantii 20g, Radix Glehniae 100g, Bulbus Lilii 100g, Folium Isatidis 30g, Flos Sophorae 50g, Herba Patriniae 20g, Indigo Naturalis 50g, Cornu Bubali powder 50g, Radix Salviae Miltiorrhizae 15g, Rhizoma Zingiberis 5g, Herba Schizonepetae 5g, Radix Saposhnikoviae 5g, Radix Angelicae Sinensis 5g, Radix Paeoniae Alba 5g, Cortex Phellodendri 5g.Prepare 500 altogether.
Preparation method
A () Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Semen Coicis, raw Fructus Aurantii, Flos Sophorae, Indigo Naturalis, Cornu Bubali powder, Cortex Phellodendri are pulverized as superfine powder, superfine powder particle size range 5-45 μm, obtains fine drug powder;
B the Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Glehniae, Bulbus Lilii, Folium Isatidis, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Zingiberis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Radix Paeoniae Alba are decocted with water 2 times by (), add 8 times of water of medical material weight for the first time, decoct 1.5 hours, second time adds medical material weight 6 times of water, decoct 1 hour, merge decoction liquor, filter, it is 1.12 ~ 1.19 that filtrate is concentrated into relative density; Then adding ethanol makes alcohol content be 80%, leave standstill after 9 hours and filter, filtrate 55 DEG C of concentrating under reduced pressure, are concentrated into the clear paste that relative density is 1.20-1.30, and clear paste is 180 DEG C in spray dryer inlet temperature, outlet temperature is 70 DEG C, under moisture less than 8% condition, carry out spraying dry, the granule that spraying dry obtains is pulverized, cross 80 mesh sieves, obtain drug spray xeraphium;
C (), by fine drug powder obtained for step (a) and the obtained drug spray xeraphium of step (b), mix homogeneously, obtains active Chinese drug component material of the present invention;
D the active component of () Chinese medicine composition of the present invention adds dextrin, magnesium stearate etc., dry granulation, cross 60 mesh sieves, load No. 00 capsule capsule.
Usage and dosage: each 4-5 grain, every day 3 times.It within 30 days, is a course for the treatment of.
Embodiment 2 the present invention treats the preparation of psoriatic Chinese medicinal tablet
Prescription: Radix Rehmanniae 110g, Fructus Ligustri Lucidi 13g, Herba Ecliptae 17g, Fructus Lycii 13g, Radix Ophiopogonis 22g, Rhizoma Imperatae 25g, Radix Arnebiae (Radix Lithospermi) 35g, Flos Lonicerae 18g, Fructus Forsythiae 22g, Radix Paeoniae Rubra 18g, Cortex Moutan 22g, Radix Isatidis 25g, Herba Taraxaci 22g, Herba Violae 18g, Fructus Kochiae 35g, Cortex Dictamni 25g, Radix Sophorae Flavescentis 5g, Zaocys 8g, Periostracum Cicadae 12g, Rhizoma Smilacis Glabrae 25g, Semen Coicis 35g, raw Fructus Aurantii 18g, Radix Glehniae 110g, Bulbus Lilii 90g, Folium Isatidis 35g, Flos Sophorae 45g, Herba Patriniae 22g, Indigo Naturalis 45g, Cornu Bubali powder 55g, Radix Salviae Miltiorrhizae 13g, Rhizoma Zingiberis 6g, Herba Schizonepetae 4g, Radix Saposhnikoviae 6g, Radix Angelicae Sinensis 4g, Radix Paeoniae Alba 6g, Cortex Phellodendri 4g.Prepare 500 altogether.
Preparation method
A () Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Semen Coicis, raw Fructus Aurantii, Flos Sophorae, Indigo Naturalis, Cornu Bubali powder, Cortex Phellodendri are pulverized as superfine powder, superfine powder particle size range 5-45 μm, obtains fine drug powder;
B the Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Glehniae, Bulbus Lilii, Folium Isatidis, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Zingiberis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Radix Paeoniae Alba are decocted with water 2 times by (), add 8 times of water of medical material weight for the first time, decoct 1.5 hours, second time adds medical material weight 6 times of water, decoct 1 hour, merge decoction liquor, filter, it is 1.12 ~ 1.19 that filtrate is concentrated into relative density; Then adding ethanol makes alcohol content be 80%, leave standstill after 8 hours and filter, filtrate 60 DEG C of concentrating under reduced pressure, are concentrated into the clear paste that relative density is 1.20-1.30, and clear paste is 200 DEG C in spray dryer inlet temperature, outlet temperature is 90 DEG C, under moisture less than 8% condition, carry out spraying dry, the granule that spraying dry obtains is pulverized, cross 80 mesh sieves, obtain drug spray xeraphium;
C (), by fine drug powder obtained for step (a) and the obtained drug spray xeraphium of step (b), mix homogeneously, obtains active Chinese drug component material of the present invention;
D the active component of () Chinese medicine composition of the present invention adds starch, mix homogeneously, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 30 mesh sieves and granulate, in 75 DEG C of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, subpackage, outer package, censorship is qualified, obtains tablet.
Usage and dosage: each 4-5 sheet, every day 3 times.It within 30 days, is a course for the treatment of.
Embodiment 3 the present invention treats the preparation of psoriatic Chinese medicine capsules
Prescription: Radix Rehmanniae 90g, Fructus Ligustri Lucidi 17g, Herba Ecliptae 13g, Fructus Lycii 17g, Radix Ophiopogonis 18g, Rhizoma Imperatae 35g, Radix Arnebiae (Radix Lithospermi) 25g, Flos Lonicerae 22g, Fructus Forsythiae 18g, Radix Paeoniae Rubra 22g, Cortex Moutan 18g, Radix Isatidis 35g, Herba Taraxaci 18g, Herba Violae 22g, Fructus Kochiae 25g, Cortex Dictamni 35g, Radix Sophorae Flavescentis 45g, Zaocys 12g, Periostracum Cicadae 8g, Rhizoma Smilacis Glabrae 35g, Semen Coicis 25g, raw Fructus Aurantii 22g, Radix Glehniae 90g, Bulbus Lilii 110g, Folium Isatidis 25g, Flos Sophorae 55g, Herba Patriniae 18g, Indigo Naturalis 55g, Cornu Bubali powder 45g, Radix Salviae Miltiorrhizae 17g, Rhizoma Zingiberis 4g, Herba Schizonepetae 6g, Radix Saposhnikoviae 4g, Radix Angelicae Sinensis 6g, Radix Paeoniae Alba 4g, Cortex Phellodendri 6g.Prepare 500 altogether.
Preparation method
A () Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Zaocys, Periostracum Cicadae, Semen Coicis, raw Fructus Aurantii, Flos Sophorae, Indigo Naturalis, Cornu Bubali powder, Cortex Phellodendri are pulverized as superfine powder, superfine powder particle size range 5-45 μm, obtains fine drug powder;
B the Radix Rehmanniae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Lycii, Radix Ophiopogonis, Rhizoma Imperatae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Radix Isatidis, Herba Taraxaci, Herba Violae, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Glehniae, Bulbus Lilii, Folium Isatidis, Herba Patriniae, Radix Salviae Miltiorrhizae, Rhizoma Zingiberis, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Radix Paeoniae Alba are decocted with water 2 times by (), add 8 times of water of medical material weight for the first time, decoct 1.5 hours, second time adds medical material weight 6 times of water, decoct 1 hour, merge decoction liquor, filter, it is 1.12 ~ 1.19 that filtrate is concentrated into relative density; Then adding ethanol makes alcohol content be 80%, leave standstill after 12 hours and filter, filtrate 55 DEG C of concentrating under reduced pressure, are concentrated into the clear paste that relative density is 1.20-1.30, and clear paste is 180 DEG C in spray dryer inlet temperature, outlet temperature is 70 DEG C, under moisture less than 8% condition, carry out spraying dry, the granule that spraying dry obtains is pulverized, cross 80 mesh sieves, obtain drug spray xeraphium;
C (), by fine drug powder obtained for step (a) and the obtained drug spray xeraphium of step (b), mix homogeneously, obtains active Chinese drug component material of the present invention;
D the active component of () Chinese medicine composition of the present invention adds dextrin, magnesium stearate etc., dry granulation, cross 60 mesh sieves, load No. 00 capsule capsule.
Usage and dosage: each 4-5 grain, every day 3 times.It within 30 days, is a course for the treatment of.
Embodiment 4 the present invention treats the preparation of psoriatic Chinese medicinal tablet
Prescription: Radix Rehmanniae 120g, Fructus Ligustri Lucidi 10g, Herba Ecliptae 20g, Fructus Lycii 10g, Radix Ophiopogonis 25g, Rhizoma Imperatae 20g, Radix Arnebiae (Radix Lithospermi) 40g, Flos Lonicerae 15g, Fructus Forsythiae 25g, Radix Paeoniae Rubra 15g, Cortex Moutan 25g, Radix Isatidis 20g, Herba Taraxaci 25g, Herba Violae 15g, Fructus Kochiae 40g, Cortex Dictamni 20g, Radix Sophorae Flavescentis 55g, Zaocys 5g, Periostracum Cicadae 15g, Rhizoma Smilacis Glabrae 20g, Semen Coicis 40g, raw Fructus Aurantii 15g, Radix Glehniae 120g, Bulbus Lilii 80g, Folium Isatidis 40g, Flos Sophorae 45g, Herba Patriniae 25g, Indigo Naturalis 45g, Cornu Bubali powder 55g, Radix Salviae Miltiorrhizae 10g, Rhizoma Zingiberis 7g, Herba Schizonepetae 3g, Radix Saposhnikoviae 7g, Radix Angelicae Sinensis 3g, Radix Paeoniae Alba 7g, Cortex Phellodendri 3g.Prepare 500 altogether.
Preparation method is with embodiment 2.
Usage and dosage: each 4-5 grain, every day 3 times.It within 30 days, is a course for the treatment of.
Embodiment 5 the present invention treats the preparation of psoriatic Chinese medicine capsules
Prescription: Radix Rehmanniae 80g, Fructus Ligustri Lucidi 20g, Herba Ecliptae 10g, Fructus Lycii 20g, Radix Ophiopogonis 15g, Rhizoma Imperatae 40g, Radix Arnebiae (Radix Lithospermi) 20g, Flos Lonicerae 25g, Fructus Forsythiae 15g, Radix Paeoniae Rubra 25g, Cortex Moutan 15g, Radix Isatidis 40g, Herba Taraxaci 15g, Herba Violae 25g, Fructus Kochiae 20g, Cortex Dictamni 40g, Radix Sophorae Flavescentis 45g, Zaocys 15g, Periostracum Cicadae 5g, Rhizoma Smilacis Glabrae 40g, Semen Coicis 20g, raw Fructus Aurantii 25g, Radix Glehniae 80g, Bulbus Lilii 120g, Folium Isatidis 20g, Flos Sophorae 55g, Herba Patriniae 15g, Indigo Naturalis 55g, Cornu Bubali powder 45g, Radix Salviae Miltiorrhizae 20g, Rhizoma Zingiberis 3g, Herba Schizonepetae 7g, Radix Saposhnikoviae 3g, Radix Angelicae Sinensis 7g, Radix Paeoniae Alba 3g, Cortex Phellodendri 7g.Prepare 500 altogether.
Preparation method is with embodiment 1.
Usage and dosage: each 4-5 grain, every day 3 times.It within 30 days, is a course for the treatment of.
Carried out clinical trial to the psoriatic capsule for the treatment of prepared by the embodiment of the present invention 1, Details as Follows:
Physical data
Select 650 examples, the psoriatic that 1998-2010 is medical in here, male patient 300 example, female patient 350 example, oldest patient 72 years old, age minimum patient 16 years old, 44 years old mean age.Wherein extremity suffer from psoriasis person 208 example, and shirtfront back head suffers from psoriasis person 292 example, and whole body suffers from psoriasis person 150 example, the most elder of the course of disease 20 years, the shortest 1 year.
Therapeutic Method: give Chinese medicinal composition capsules agent of the present invention, each 5, every day 3 times 1 month was 1 course for the treatment of.
Efficacy determination: treat criterion after 1 course for the treatment of
Cure: psoriatic lesion disappears, preventing from scar;
Effective: psoriatic lesion disappears more than 70%;
Invalid: without significant change before and after curing psoriasis.
Result: cure 158 examples oral 1 course for the treatment of, a course cure rate 24.31%; Cure 204 examples oral 2 courses for the treatment of, 2 course cure rates 31.38%; Cure 172 examples oral 3 courses for the treatment of, 3 course cure rates 26.46%; Oral 3 courses for the treatment of effective 105 are routine, oral 3 ineffective courses 11 example.The follow-up of patients cured 3 years, recurs 4 people, relapse rate 0.75%.
Total effective rate 98.31%, cure rate 82.16%, obvious effective rate 16.15%, inefficiency 1.69%.A routine untoward reaction is had no in 650 routine patients.
Model case:
Lee's tinkling of pieces of jade, female, 20 years old, first visit on February 3 in 2002, readme suffers from psoriasis 7 years, and without obvious inducement before 7 years, red point appears in anterior part of chest skin, shape, as sorghum grain, above covers white scales, and skin is itched, after expand gradually, form lamellar, circular, skin lesion place color is red, above covers a large amount of lamellar white scales, comes off layer by layer, itch night and increase the weight of, be developed to shirtfront gradually, back part presents large lamellar skin lesion, is psoriasis after diagnosing.Once multiple Pharmaceuticals was taken, and external use anti pruritic ointment, effect is all not good.Existing disease is seen, head, shirtfront, back part present large lamellar skin lesion, and circular, skin lesion place color is red, and above cover a large amount of lamellar white thin skin, itching heavily in skin lesion place, grabs, and come off a large amount of silver bits.Patient often catches a cold, pharyngeal pain, is hard and dry, and it is poor that stomach receives food, and poor sleep (night itch weight), body of the tongue is light red, tongue fur BOHUANG, pulse condition stringy and thready pulse.Dialectical is heat in blood blood-dryness type psoriasis, and the rule for the treatment of is nourshing Yin and drynsessmoistening prescription to nourish blood, heat clearing away profit of holding concurrently blood-cooling itch-relieving.Giving the present invention and treat psoriatic Chinese medicinal capsule, each 5, every day 3 times, 30 days was 1 course for the treatment of.After 1 course for the treatment of, patients head, shirtfront, back part skin lesion disappear substantially, and without staying cicatrix, being consolidate curative effect, continuing to give the present invention and treat psoriatic Chinese medicinal capsule, each 4, every day 3 times, 30 days was 1 course for the treatment of.After continuing for 1 course for the treatment of, lesions of patients disappears completely, does not stay cicatrix, follows up a case by regular visits to and has no recurrence in 10 years.
Certain English of side, female, 16 years old, middle school student, first visit on May 10 in 2003.Suffer from psoriasis 4 years, increase the weight of 1 year.Existing two upper limb, two lower limb and head present large stretch of circular skin lesion, and skin lesion place color is red, above covers a large amount of lamellar white scales, grabs, and come off a large amount of white scales, annual winter in spring aggravation.All be diagnosed as psoriasis in Duo Jia hospital, once oral multi-medicament treatment, so far there are no takes a turn for the better, and stomach is received good, menstrual blood volume is on the low side, and defecate partially dry, body of the tongue is light red, and tongue fur is partially yellow, pulse condition stringy and thready pulse, the dry blood-heat type of dialectical blood, the rule for the treatment of is nourshing Yin and drynsessmoistening prescription to nourish blood, heat clearing away profit of holding concurrently blood-cooling itch-relieving.Giving the present invention and treat psoriatic Chinese medicinal capsule, each 5, every day 3 times, 30 days was 1 course for the treatment of.After 1 course for the treatment of, patients head, shirtfront, back part skin lesion disappear about 60%, and the good standard of two upper limb skin lesion is the most obvious, and skin is itched and alleviated, and whole body is light, without significant discomfort sense.After following the service 1 course for the treatment of, two upper limb, two lower limb and head skin lesion all disappear, and also without cicatrix, skin is not itched, and reaches clinical cure.Follow up a case by regular visits to and do not recur for 9 years.
Yao's moral, man, 46 years old, first visit on April 2 in 2008, suffers from psoriasis 1 year, and existing head, extremity, shirtfront, back all have skin lesion, skin lesion accounts for whole body about 60%, and skin is rounded, as red in Semen arachidis hypogaeae size, skin lesion place cortex, on cover a large amount of white scales, skin is itched, and night increases the weight of, play white scales sheet being covered with and coming off morning, sleep can, defecate partially dry, body of the tongue is light red, and the tongue heart is partially yellow, pulse condition stringy and rolling pulse.Many hospital diagnosis are psoriasis, do not heal through multi-treatment.Giving the present invention and treat psoriatic Chinese medicinal capsule, each 5, every day 3 times, 30 days was 1 course for the treatment of.After 1 course for the treatment of, entire patient's skin lesion disappears about 80%, and skin is itched and subtracted greatly.After continuing for 1 course for the treatment of, lesions of patients disappears completely, does not stay cicatrix, follows up a case by regular visits to and has no recurrence in 3 years.
Claims (7)
1. treat a psoriatic Chinese medicine, be made up of the crude drug of following weight portion:
Radix Rehmanniae 80-120 part, Fructus Ligustri Lucidi 10-20 part, Herba Ecliptae 10-20 part, Fructus Lycii 10-20 part, Radix Ophiopogonis 15-25 part, Rhizoma Imperatae 20-40 part, Radix Arnebiae (Radix Lithospermi) 20-40 part, Flos Lonicerae 15-25 part, Fructus Forsythiae 15-25 part, Radix Paeoniae Rubra 15-25 part, Cortex Moutan 15-25 part, Radix Isatidis 20-40 part, Herba Taraxaci 15-25 part, Herba Violae 15-25 part, Fructus Kochiae 20-40 part, Cortex Dictamni 20-40 part, Radix Sophorae Flavescentis 45-55 part, Zaocys 5-15 part, Periostracum Cicadae 5-15 part, Rhizoma Smilacis Glabrae 20-40 part, Semen Coicis 20-40 part, raw Fructus Aurantii 15-25 part, Radix Glehniae 80-120 part, Bulbus Lilii 80-120 part, Folium Isatidis 20-40 part, Flos Sophorae 45-55 part, Herba Patriniae 15-25 part, Indigo Naturalis 45-55 part, Cornu Bubali powder 45-55 part, Radix Salviae Miltiorrhizae 10-20 part, Rhizoma Zingiberis 3-7 part, Herba Schizonepetae 3-7 part, Radix Saposhnikoviae 3-7 part, Radix Angelicae Sinensis 3-7 part, Radix Paeoniae Alba 3-7 part, Cortex Phellodendri 3-7 part.
2. the psoriatic Chinese medicine for the treatment of according to claim 1, is characterized in that, is made up of the crude drug of following weight portion:
Radix Rehmanniae 90-110 part, Fructus Ligustri Lucidi 13-17 part, Herba Ecliptae 13-17 part, Fructus Lycii 13-17 part, Radix Ophiopogonis 18-22 part, Rhizoma Imperatae 25-35 part, Radix Arnebiae (Radix Lithospermi) 25-35 part, Flos Lonicerae 18-22 part, Fructus Forsythiae 18-22 part, Radix Paeoniae Rubra 18-22 part, Cortex Moutan 18-22 part, Radix Isatidis 25-35 part, Herba Taraxaci 18-22 part, Herba Violae 18-22 part, Fructus Kochiae 25-35 part, Cortex Dictamni 25-35 part, Radix Sophorae Flavescentis 45-55 part, Zaocys 8-12 part, Periostracum Cicadae 8-12 part, Rhizoma Smilacis Glabrae 25-35 part, Semen Coicis 25-35 part, raw Fructus Aurantii 18-22 part, Radix Glehniae 90-110 part, Bulbus Lilii 90-110 part, Folium Isatidis 25-35 part, Flos Sophorae 45-55 part, Herba Patriniae 18-22 part, Indigo Naturalis 45-55 part, Cornu Bubali powder 45-55 part, Radix Salviae Miltiorrhizae 13-17 part, Rhizoma Zingiberis 4-6 part, Herba Schizonepetae 4-6 part, Radix Saposhnikoviae 4-6 part, Radix Angelicae Sinensis 4-6 part, Radix Paeoniae Alba 4-6 part, Cortex Phellodendri 4-6 part.
3. the psoriatic Chinese medicine for the treatment of according to claim 2, is characterized in that, is made up of the crude drug of following weight portion:
100 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 15 parts, Herba Ecliptae 15 parts, Fructus Lycii 15 parts, Radix Ophiopogonis 20 parts, Rhizoma Imperatae 30 parts, Radix Arnebiae (Radix Lithospermi) 30 parts, Flos Lonicerae 20 parts, Fructus Forsythiae 20 parts, Radix Paeoniae Rubra 20 parts, Cortex Moutan 20 parts, Radix Isatidis 30 parts, Herba Taraxaci 20 parts, Herba Violae 20 parts, the Fructus Kochiae 30 parts, Cortex Dictamni 30 parts, Radix Sophorae Flavescentis 50 parts, Zaocys 10 parts, Periostracum Cicadae 10 parts, Rhizoma Smilacis Glabrae 30 parts, Semen Coicis 30 parts, raw Fructus Aurantii 20 parts, Radix Glehniae 100 parts, Bulbus Lilii 100 parts, Folium Isatidis 30 parts, 50 parts, Flos Sophorae, Herba Patriniae 20 parts, Indigo Naturalis 50 parts, Cornu Bubali powder 50 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Zingiberis 5 parts, Herba Schizonepetae 5 parts, Radix Saposhnikoviae 5 parts, Radix Angelicae Sinensis 5 parts, Radix Paeoniae Alba 5 parts, Cortex Phellodendri 5 parts.
4. the psoriatic Chinese medicine for the treatment of according to claim 1 or 2 or 3, is characterized in that, the dosage form of described Chinese medicine is oral formulations.
5. the psoriatic Chinese medicine for the treatment of according to claim 1 or 2 or 3, is characterized in that, the dosage form of described Chinese medicine is capsule.
6. the psoriatic Chinese medicine for the treatment of according to claim 1 or 2 or 3, is characterized in that, the dosage form of described Chinese medicine is tablet.
7. the preparation method of claim 1 or the psoriatic Chinese medicine for the treatment of described in 2 or 3, it is characterized in that, through following steps: raw material of Chinese medicine medical material is processed through extraction or other modes, make active Chinese drug component material, this active Chinese drug component material mixes with medicine acceptable carrier separately, namely can be made into according to galenic pharmacy routine techniques.
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| CN103893649A (en) * | 2014-03-26 | 2014-07-02 | 叶葵 | Traditional Chinese medicine for treating psoriasis |
| CN104042978A (en) * | 2014-06-28 | 2014-09-17 | 蚌埠明日欣医药有限公司 | Traditional Chinese medicine mixture for treating pityriasis rosea |
| CN104984132A (en) * | 2015-07-22 | 2015-10-21 | 袁玥 | Traditional Chinese medicine for treating psoriasis caused by dampness |
| CN105521434A (en) * | 2015-11-30 | 2016-04-27 | 吕翠云 | Traditional Chinese medicine for treating head and face psoriasis |
| CN105687939A (en) * | 2016-04-09 | 2016-06-22 | 张志强 | Oral-administration traditional Chinese medicine for treating psoriasis and preparation method thereof |
| CN105902908A (en) * | 2016-04-24 | 2016-08-31 | 邹洪胜 | Traditional Chinese medicinal composition for treating psoriasis |
| CN110404027A (en) * | 2019-08-22 | 2019-11-05 | 张起江 | It is a kind of to treat dermopathic Chinese medicine composition and preparation method |
| CN114796139A (en) * | 2022-04-28 | 2022-07-29 | 阿克曼皮肤医院投资有限公司 | Traditional Chinese medicine pill for treating blood-heat psoriasis vulgaris |
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