CN103330961B - A device for recovering target components of medical cavity contents - Google Patents
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Abstract
Description
技术领域technical field
本发明涉及由悬浮液容器、逐级过滤装置和目的成分收集装置的器械,具体涉及一种医用人体腔道内容物目标成分回收的器械,属于医疗器械技术领域。The invention relates to a device composed of a suspension container, a step-by-step filter device and a target component collection device, in particular to a medical device for recovering target components from the contents of a human cavity, and belongs to the technical field of medical devices.
背景技术Background technique
人体胃肠道内容物有食物残渣、菌群、寄生虫卵等多种有行成分,有肠道分泌生成的体液成分,有因为各种原因进入腔道内的异物和液体,还有通过内镜下切除但是不易直接取出的细碎肿瘤组织。在临床和研究过程中,要分辨和获得这些目的成分,只有依赖有效的器械辅助分离。下面以制备粪菌移植菌液与收集大量粪便虫卵的临床背景为例,简要说明人体腔道内容物目的成分收集的重要性。The contents of the human gastrointestinal tract include food residues, flora, parasite eggs and other active components, as well as body fluid components secreted by the intestinal tract, foreign bodies and liquids that enter the cavity due to various reasons, and endoscopic Finely divided tumor tissue that has been resected but is not easy to remove directly. In the clinical and research process, the only way to distinguish and obtain these target components is to rely on effective instrument-assisted separation. Taking the clinical background of preparing fecal bacteria transplantation liquid and collecting a large number of fecal eggs as an example, the importance of collecting the target components of human cavity contents is briefly explained below.
正常人肠道中的菌群是已经被认为是人体内一个特殊的器官,粪菌移植被认为是一种特殊的器官移植。肠道的细菌约为1000至1050种,目前人类对其中绝大部分细菌的功能,以及不同细菌之间按照什么机制有机地工作,都尚不清楚。近来,现代医学已经越来越认识到肠道细菌在人体内的重要作用,已经将维持或者重建人体肠道正常菌群作为多种疾病的重要治疗手段。常用益生菌药物和食物只是将肠道的一种或者几种细菌,经过体外专门的培养,然后按照一定的量进行包装。然而,因为所纳入人体肠道的细菌数量和种类都非常有限,所以其治疗价值也很有限。最近5年,粪菌移植已经逐渐得到重视,尤其是对于常用抗生素等药物治疗无效的感染相关的疾病,其治疗价值显得尤为重要,比如治疗抗生素相关性腹泻、难治性炎症性肠病、难治性肠易激综合征、免疫相关性难治性腹泻、肥胖、食物过敏、抑郁症肠道症状、脂肪肝等。The flora in the intestinal tract of normal people has been considered as a special organ in the human body, and fecal microbiota transplantation is considered a special organ transplantation. There are about 1,000 to 1,050 species of bacteria in the gut. At present, the functions of most of these bacteria and the mechanism by which different bacteria work organically are still unclear. Recently, modern medicine has increasingly recognized the important role of intestinal bacteria in the human body, and has taken maintaining or rebuilding the normal intestinal flora of the human body as an important treatment for many diseases. Commonly used probiotic drugs and foods are just one or several types of bacteria in the intestine, which are specially cultured in vitro, and then packaged according to a certain amount. However, because the number and types of bacteria incorporated into the human gut are very limited, their therapeutic value is also limited. In the past 5 years, fecal microbiota transplantation has gradually gained attention, especially for infection-related diseases that are ineffective in the treatment of commonly used antibiotics and other drugs, its therapeutic value is particularly important, such as the treatment of antibiotic-associated diarrhea, refractory inflammatory bowel disease, refractory Treatable irritable bowel syndrome, immune-related refractory diarrhea, obesity, food allergy, intestinal symptoms of depression, fatty liver, etc.
科学发展至今,虽然已经有少数研究通过肠镜、胃镜、鼻胃管、空肠管、胶囊等将粪便悬浮液或者粪菌悬液输送到胃肠道内,实现粪菌移植,但是,这些方法都存在如下问题:(1)制备粪液的医务人员无论是从粪水的视觉还是心理上难受,甚至有人拒绝这些工作;(2)制备程序的非标准化会导致治疗程序对人力成本增加;(3)既往的研究均为涉及如何避免寄生虫肠道感染粪的可能性,这在粪菌移植的方法学上缺乏一种新的突破,即在获取菌液的同时,必须有效滤除虫卵预防寄生虫传染,同时还尽可能滤除其它杂质和臭味;(4)常规人工的过滤措施,难以确保粪菌标本的质量可靠、可控。因此,本发明在于设计一种用于粪液制备、过滤和收集的标准化装置。国外有用咖啡机手动制备粪菌液体的临床报道。然而,这样的做法,不仅浪费匀浆和过滤设备,操作过程中耗时费力,还对处理一桶大便的医务人员,在心理上是一种挑战性的考验。目前尚未见国内外论文和专利文献公开用于粪菌液制备的标准化器械。Since the development of science, although there have been a few studies on the delivery of fecal suspension or fecal suspension into the gastrointestinal tract through colonoscopy, gastroscopy, nasogastric tube, jejunal tube, capsules, etc., to achieve fecal bacterial transplantation, these methods exist. The following problems: (1) The medical staff who prepare the feces suffer from the visual and psychological discomfort of the feces, and some even refuse these jobs; (2) The non-standardization of the preparation procedure will lead to an increase in the labor cost of the treatment procedure; (3) Previous studies were all about how to avoid the possibility of parasite intestinal infection of feces, which lacks a new breakthrough in the methodology of fecal microbe transplantation, that is, while obtaining the bacterial fluid, it is necessary to effectively filter out worm eggs to prevent parasitism (4) Conventional artificial filtration measures are difficult to ensure reliable and controllable quality of fecal fungus samples. Therefore, the present invention consists in devising a standardized device for the preparation, filtration and collection of liquid manure. There are clinical reports on manual preparation of fecal bacteria liquid by coffee machine abroad. However, such an approach not only wastes homogenization and filtration equipment, is time-consuming and laborious during the operation, but also is a psychologically challenging test for medical staff who handle a bucket of stool. At present, there are no domestic and foreign papers and patent documents disclosing standardized instruments for the preparation of fecal liquid.
还一种重要的临床需要就是从粪便中大量虫卵收集。找到肠道虫卵是诊断肠道寄生虫病的金标准。西方发达国家寄生虫病已经少见,收集虫卵的临床需要已经不突出。但是在中国、东南亚及非洲等欠发到地区,寄生虫病还很常见。经典的虫卵检查查找方法是用极其少许的粪便制备涂片,再在显微镜下找虫卵。这样的检查方法,阳性检出率低,容易导致寄生虫感染漏诊。本发明可以实现收集排出体外的粪便或者内镜下抽吸的肠液成分,在制备成粪便悬液后,通过不同直径的连续过滤设计,高效获得粪便中存在的虫卵。Another important clinical need is the collection of large numbers of eggs from feces. Finding intestinal worm eggs is the gold standard for diagnosing intestinal parasitic diseases. Parasitic diseases are rare in western developed countries, and the clinical need for collecting eggs is no longer prominent. However, parasitic diseases are still very common in underdeveloped areas such as China, Southeast Asia, and Africa. The classic way to check for eggs is to use a very small amount of feces to prepare a smear, and then look for eggs under a microscope. Such an inspection method has a low positive detection rate, which easily leads to missed diagnosis of parasitic infection. The invention can realize the collection of excreted feces or intestinal fluid components sucked under the endoscope, and after being prepared into a feces suspension, the worm eggs existing in the feces can be efficiently obtained through continuous filtration designs of different diameters.
另一种临床需要,是经内镜下抽吸的胃肠液体用于化验,其主要目的是获得液体成分,但是,抽吸过程中必然混杂食物残渣等各种固体成分;经尿道内镜下抽吸的膀胱液体用于化验检查,其主要目的是获得液体和其中脱落细胞等有形成分,但是,抽吸过程中可能会混杂尿液中结石等较大残渣等固体成分;经过气管镜获取气管内分泌液体和灌洗液体,其主要目的是获得液体和其中脱落细胞等有形成分,但是,其中混杂明显的组织块和浓稠痰液等。过滤去除残渣的器械对液体收集质量和数量有重要作用。本临床需要可以在以上用于粪菌液收集的器械中得到满足。Another clinical need is to use endoscopically aspirated gastrointestinal fluid for laboratory testing, the main purpose of which is to obtain liquid components, however, various solid components such as food residues must be mixed during the suction process; The aspirated bladder fluid is used for laboratory examination, and its main purpose is to obtain the liquid and exfoliated cells and other formed components. However, solid components such as stones and other large residues in the urine may be mixed during the suction process; The main purpose of tracheal endocrine fluid and lavage fluid is to obtain liquid and exfoliated cells and other formed components, but there are obvious tissue pieces and thick sputum mixed in it. Devices that filter to remove debris play an important role in the quality and quantity of fluid collected. This clinical need can be met in the above instruments for collecting fecal liquid.
基于诸如以上的临床需要,设计一种在体外回收人体腔道内容物目标成分的器械,广泛用于多种临床需要。Based on the clinical needs such as the above, a device for recovering the target components of the human cavity contents in vitro is designed, which is widely used in various clinical needs.
发明内容Contents of the invention
本发明的目的是:The purpose of the present invention is:
提供一种涉及悬浮液容器、分级过滤装置和目标成分收集装置的器械,具体为一种医用腔道内容物目标成分回收器械,方便操作者操作,主要实现:(1)制备粪便悬液和最大程度获得粪中菌群,并同时有效去除未消化食物残渣、虫卵、粪液中的黄色粘液、臭味,用于粪菌移植治疗;(2)分离并大量收集粪便悬液中的寄生虫卵,用于检查;(3)经过消化道内镜收集腔道内分泌液体和细胞成分,同时去除胃肠食物残渣,用于检查诊断;(4)经气管镜收集气管中的分泌液体,同时去除浓稠痰液等,用于检查诊断。Provide a device involving a suspension container, a grading filter device and a target component collection device, specifically a device for recovering target components of the contents of a medical cavity, which is convenient for the operator and mainly achieves: (1) preparation of feces suspension and maximum obtain fecal flora to a certain extent, and effectively remove undigested food residues, insect eggs, yellow mucus, and odor in feces at the same time, for fecal microbiota transplantation treatment; (2) separate and collect a large number of parasites in fecal suspension Eggs are used for examination; (3) endocrine fluid and cell components are collected through gastrointestinal endoscopy, and gastrointestinal food residues are removed at the same time for examination and diagnosis; (4) secretion fluid in the trachea is collected through bronchoscopy, and Thick sputum, etc., for examination and diagnosis.
本发明所述一种腔道内容物目标成分回收的器械通过以下方法实现:According to the present invention, a device for recovering target components of cavity contents is realized by the following methods:
一种医用腔道内容物目标成分回收器械,包括悬浮液容器、逐级过滤装置和目标成分收集装置,悬浮液容器至少设有1个进液通道、1个排气或负压吸引通道、1个排液通道。A device for recovering target components of the contents of a medical cavity, including a suspension container, a step-by-step filtering device, and a target component collection device. The suspension container is provided with at least one liquid inlet channel, one exhaust or negative pressure suction channel, and one a drainage channel.
所述进液通道在于连通粪菌悬液制备液(如生理盐水等)供给源,或者用于连接内镜抽吸孔道获得腔道内液体。进液通道可通过手动或者自动的程序控制进液的量、速度和时间。流体通过进液通道所需力量可以是通过正压推注、负压吸引、重力、滚动轴等作用方式实现。The liquid inlet channel is used to communicate with the supply source of the fecal suspension preparation liquid (such as physiological saline, etc.), or to connect the suction channel of the endoscope to obtain the liquid in the cavity. The liquid inlet channel can control the amount, speed and time of the liquid inlet through manual or automatic procedures. The force required for the fluid to pass through the liquid inlet channel can be realized by means of positive pressure injection, negative pressure suction, gravity, rolling axis, etc.
悬浮液容器中的排气或负压吸引通道位于该容器上部,至少1个。悬浮液容器中的排液通道)至少1个,其开口位于容器底部,可以与容器底部齐平或者低于底部。所述悬浮液容器底部为设有坡面帮助液体由1个排液通道流出。悬浮液容器的外部底面为平底方便平放,但是容器底部内面优选为斜面或弧面,排液通道开口的位置为悬浮液容器内底部最低的位置,方便液体向流出口聚集。悬浮液容器在排液时的工作状态为直立。The exhaust or negative pressure suction channel in the suspension container is located on the upper part of the container, at least one. There is at least one drainage channel in the suspension container, the opening of which is located at the bottom of the container, which may be flush with or lower than the bottom of the container. The bottom of the suspension container is provided with a slope to help the liquid flow out from a drainage channel. The outer bottom of the suspension container is flat and convenient to lay flat, but the inner surface of the bottom of the container is preferably a slope or an arc, and the position of the opening of the drainage channel is the lowest position in the bottom of the suspension container to facilitate the accumulation of liquid to the outlet. The working state of the suspension container is upright when it is draining.
所述悬浮液容器内壁内设有用于混匀、搅拌和粉碎腔道内容物的辅助粉碎刺,辅助粉碎刺为边缘锐利的钉、片、棱样结构。可附加三棱柱、刀片样、尖锥形等边缘锐利的几何结构设计。悬浮液容器的外观可以是圆桶、扁桶、正方体、长方体及不规则形状,有盖、盖中间有进液通道、排气或负压吸引通道。The inner wall of the suspension container is provided with auxiliary pulverizing thorns for mixing, stirring and crushing the contents of the cavity, and the auxiliary pulverizing thorns are in the form of sharp-edged nails, sheets, and ribs. Geometric structures with sharp edges such as triangular prisms, blade-like shapes, and pointed cones can be added. The appearance of the suspension container can be drum, flat barrel, cube, cuboid and irregular shape, with a cover, and there is a liquid inlet channel, exhaust or negative pressure suction channel in the middle of the cover.
所述悬浮液容器外壳设有用于闭塞各管道的活塞样假体。The suspension container housing is provided with piston-like prostheses for occluding the respective conduits.
所述逐级过滤装置为在悬浮液容器内设至少1个过滤网,所述过滤网的形状为开口向上的倒梯形条状槽,倒梯形条状槽表面为滤网结构;所述悬浮液容器的上部侧面一侧开口供倒梯形条状槽水平插入,通过卡合或螺旋的方式定位形成密闭结构。这种形式的过滤网如“抽屉”样的结构可以方便插入和取出,还可设有手柄。所述悬浮液容器内设有1个以上过滤网时,按照滤孔直径从大到小的次序,自上而下设置2-10个过滤网连续叠置在一起,各过滤网过滤孔直径在5.0mm–0.001mm之间选择。依据临床实际过滤的需求,优选将各级过滤部件大小、形状完全相同,仅滤网孔径不同,方便置换不同孔径的滤网,或者利用假体过滤部件(无过滤网或者无过滤意义的大直径过滤网)置换以减少过滤层次。该设计可以满足特定滤孔直径的滤网收集目的成分。The step-by-step filtering device is to set at least one filter screen in the suspension container, the shape of the filter screen is an inverted trapezoidal strip groove with an upward opening, and the surface of the inverted trapezoidal strip groove is a filter screen structure; the suspension One side of the upper side of the container is open for the horizontal insertion of the inverted trapezoidal strip groove, and the closed structure is formed by locking or screwing. The filter screen of this form can be easily inserted and taken out as a "drawer" structure, and can also be provided with a handle. When more than one filter screen is provided in the suspension container, according to the order of filter hole diameters from large to small, 2-10 filter screens are arranged to be stacked together continuously from top to bottom, and the filter hole diameters of each filter screen are at Choose from 5.0mm–0.001mm. According to the actual clinical filtration requirements, it is preferable to have the same size and shape of the filter components at all levels, only the filter pore size is different, so that it is convenient to replace the filter screens with different pore sizes, or use prosthetic filter components (without filter screen or large diameter without filtering meaning) filter) replacement to reduce the filter level. The design can meet the specific filter hole diameter of the filter to collect the purpose component.
所述过滤网的过滤孔直径在5.0mm–0.001mm之间,按照滤孔直径从大到小的次序,自上而下设置1-10个过滤网。不同滤孔直径的过滤网可以共位于悬浮液容器中,该容器内至少设一级过滤结构,其过滤网滤孔直径最大5mm。The filter hole diameter of the filter screen is between 5.0mm-0.001mm, and 1-10 filter screens are arranged from top to bottom according to the order of filter hole diameter from large to small. Filter screens with different filter hole diameters can be co-located in the suspension container, and at least one level of filter structure is arranged in the container, and the maximum filter hole diameter of the filter screen is 5 mm.
所述逐级过滤装置还可以为在悬浮液容器之外还设置有至少1个副悬浮液容器,副悬浮液容器优选为“顶园底平”的容器结构,即由上下两个结构通过螺旋纹吻合而成的密闭结构,工作状态时为上下完全吻合;顶部连通来自上一级过滤之后的排液通道,盖顶上方还有一个排气或负压吸引通道,位于盖顶外表面设有活塞样假体用于闭塞液体引入和负压吸引的软管开口;下方为平底圆桶状结构;出液管道开口于过滤网下方、容器的底部,连通至过滤容器腔外;各级过滤装置通过可曲软管连通,相互并行直立,连通管中间具有连接结构,可以减少或者更换其中任何一级过滤结构。可以通过取出并旋开任何一级的过滤球形装置,可获取滤网上相应直径以上的固体成分。The step-by-step filtering device can also be provided with at least one auxiliary suspension container outside the suspension container, and the auxiliary suspension container is preferably a container structure with a "top garden and a flat bottom", that is, the upper and lower structures pass through the spiral The airtight structure is formed by matching the pattern, and the upper and lower sides are completely matched in the working state; the top is connected to the drainage channel from the upper stage of filtration, and there is an exhaust or negative pressure suction channel on the top of the cover, which is located on the outer surface of the cover. The piston-like prosthesis is used to block the hose opening for liquid introduction and negative pressure suction; the bottom is a flat-bottomed cylinder-shaped structure; the liquid outlet pipe opens below the filter screen and the bottom of the container, and is connected to the outside of the filter container cavity; filter devices at all levels They are connected by flexible hoses and stand parallel to each other. There is a connecting structure in the middle of the connecting pipes, which can reduce or replace any one of the filter structures. The solid components above the corresponding diameter on the filter can be obtained by taking out and unscrewing the filter spherical device of any stage.
副悬浮液容器同样至少设有1个进液通道、1个排气或负压吸引通道、1个排液通道,所述副悬浮液容器底部为设有坡面帮助液体由1个排液通道流出,悬浮液容器和副悬浮液容器内部各设有至少1个过滤网,所述过滤网的形状为平面网状结构。The auxiliary suspension container is also at least provided with 1 liquid inlet channel, 1 exhaust or negative pressure suction channel, and 1 liquid discharge channel. Outflow, the inside of the suspension container and the auxiliary suspension container are respectively provided with at least one filter screen, and the shape of the filter screen is a planar mesh structure.
所述悬浮液容器内设有1个以上过滤网时,按照滤孔直径从大到小的次序,自上而下设置2-10个过滤网,各过滤网过滤孔直径在5.0mm–0.001mm之间选择。When more than one filter screen is provided in the suspension container, 2-10 filter screens are arranged from top to bottom according to the order of filter hole diameters from large to small, and each filter screen has a filter hole diameter of 5.0mm-0.001mm Choose between.
所述副悬浮液容器同时设置有1个以上时,各副悬浮液容器通过可曲软管连通。When more than one auxiliary suspension container is provided at the same time, each auxiliary suspension container is connected through a flexible hose.
所属目标成分收集装置至少具有1个进液通道、1个排气或负压吸引通道,内设有或者不设有过滤网。The target component collecting device has at least one liquid inlet channel, one exhaust or negative pressure suction channel, with or without a filter screen inside.
本发明的有益效果在于:The beneficial effects of the present invention are:
本发明的医用腔道内容物目标成分回收器械,主要用于制备粪便悬液和收集细菌悬液,尽量去除杂质,有利于将制备细菌悬液的过程程序化和标准化,让更多的病人受惠于粪菌移植治疗。本发明还适合制备粪便悬液并大量收集寄生虫虫卵,提高阳性诊断率。用本发明还可用于经内镜收集胃肠腔内分泌液及腔道内细碎组织标本,经内镜收集气管内液体和脱落细胞,经内镜收集胆胰管系统液体和脱落细胞,经内镜收集泌尿生殖道内液体和脱落细胞等。本发明满足目标成分的准确和大量回收之用,能够提高临床和检验工作效益和质量,具有重要实际应用价值。The device for recovering the target components of the contents of the medical cavity of the present invention is mainly used for preparing feces suspension and collecting bacterial suspension to remove impurities as much as possible, which is beneficial to program and standardize the process of preparing bacterial suspension, so that more patients can receive Beneficial to fecal microbiota transplantation. The invention is also suitable for preparing feces suspension and collecting a large number of parasite eggs, so as to improve the positive diagnosis rate. The present invention can also be used to collect gastrointestinal cavity endocrine fluid and finely crushed tissue specimens in the cavity through endoscope, to collect intratracheal fluid and exfoliated cells through endoscope, to collect bile-pancreatic duct system fluid and exfoliated cells through endoscope, and to collect endoscopically Fluid and exfoliated cells in the genitourinary tract. The invention satisfies the purpose of accurate and mass recovery of target components, can improve the efficiency and quality of clinical and inspection work, and has important practical application value.
附图说明Description of drawings
图1为本发明的过滤网(104)形状为开口向上的倒梯形条状槽时的结构示意图。Fig. 1 is a structural schematic diagram of the filter screen (104) of the present invention when the shape is an inverted trapezoidal strip groove with an opening upward.
图2为本发明的过滤网(104)形状为开口向上的倒梯形条状槽时的局部结构示意图。Fig. 2 is a schematic diagram of a partial structure of the filter screen (104) of the present invention when the shape is an inverted trapezoidal strip groove with an upward opening.
图3为本发明的过滤网(104)的形状为网状结构的副悬浮液容器(107)的局部结构示意图。Fig. 3 is a partial structural schematic diagram of a secondary suspension container (107) in which the filter screen (104) of the present invention is in the form of a mesh structure.
其中:100、悬浮液容器;200、逐级过滤装置;300、目标成分收集装置;101、进液通道;102、排气或负压吸引通道;103、排液通道;104、过滤网;105、辅助粉碎刺;106、活塞样假体;107、副悬浮液容器;108、可曲软管。Among them: 100, suspension container; 200, step-by-step filtration device; 300, target component collection device; 101, liquid inlet channel; 102, exhaust or negative pressure suction channel; 103, liquid drainage channel; 104, filter screen; 105 106, piston-like prosthesis; 107, secondary suspension container; 108, flexible hose.
具体实施方式detailed description
一种医用腔道内容物目标成分回收器械,如图1所示,包括悬浮液容器(100)、逐级过滤装置(200)和目标成分收集装置(300),悬浮液容器(100)至少设有1个进液通道(101)、1个排气或负压吸引通道(102)、1个排液通道(103)。A device for recovering target components of the contents of a medical cavity, as shown in Figure 1, comprising a suspension container (100), a step-by-step filter device (200) and a target component collection device (300), the suspension container (100) is at least set There is one liquid inlet channel (101), one exhaust or negative pressure suction channel (102), and one liquid discharge channel (103).
所述进液通道(101)在于连通粪菌悬液制备液(如生理盐水等)供给源,或者用于连接内镜抽吸孔道获得腔道内液体。进液通道(101)可通过手动或者自动的程序控制进液的量、速度和时间。进液通道(101)优选一次性塑料软管,内径8.0mm,软管端口设计可为螺旋管结构或者弹性套入等。流体通过进液通道(101)所需力量可以是通过正压推注、负压吸引、重力、滚动轴等作用方式实现。The liquid inlet channel (101) is connected to the supply source of the fecal suspension preparation liquid (such as physiological saline, etc.), or is used to connect to the suction channel of the endoscope to obtain the liquid in the cavity. The liquid inlet channel (101) can control the amount, speed and time of liquid inlet through a manual or automatic program. The liquid inlet channel (101) is preferably a disposable plastic hose with an inner diameter of 8.0mm, and the design of the hose port can be a helical tube structure or an elastic sleeve. The force required for the fluid to pass through the liquid inlet channel (101) can be realized by means of positive pressure injection, negative pressure suction, gravity, rolling axis and the like.
悬浮液容器(100)中的排气或负压吸引通道(102)位于该容器上部,至少1个。优选位于容器盖内,优选数量为1个。The exhaust or negative pressure suction channel (102) in the suspension container (100) is located at the upper part of the container, and there is at least one. Preferably located in the lid of the container, preferably in a quantity of 1.
悬浮液容器(100)中的排液通道(103)至少1个,其开口位于容器底部,可以与容器底部齐平或者低于底部。优选采用1个排液通道(103),位于悬浮液容器(100)底部。所述悬浮液容器(100)底部为设有坡面帮助液体由1个排液通道(103)流出。悬浮液容器(100)的外部底面为平底方便平放,但是容器底部内面优选为斜面或弧面,排液通道(103)开口的位置为悬浮液容器(100)内底部最低的位置,方便液体向流出口聚集。悬浮液容器(100)在排液时的工作状态为直立。There is at least one drainage channel (103) in the suspension container (100), the opening of which is located at the bottom of the container, which may be flush with or lower than the bottom of the container. Preferably 1 drainage channel (103) is used, located at the bottom of the suspension container (100). The bottom of the suspension container (100) is provided with a slope to help the liquid flow out from a drainage channel (103). The outer bottom surface of the suspension container (100) is flat and convenient to lay flat, but the inner surface of the bottom of the container is preferably a slope or an arc surface, and the position of the opening of the drainage channel (103) is the lowest position in the bottom of the suspension container (100), which is convenient for liquid Gather towards the outlet. The working state of the suspension container (100) is upright when draining.
所述悬浮液容器(100)内壁内设有用于混匀、搅拌和粉碎腔道内容物的辅助粉碎刺(105),辅助粉碎刺(105)为边缘锐利的钉、片、棱样结构。可附加三棱柱、刀片样、尖锥形等边缘锐利的几何结构设计。悬浮液容器(100)的外观可以是圆桶、扁桶、正方体、长方体及不规则形状,优选混匀结构外观为圆桶状,深度15.0cm,上部开口径为8.0cm,有盖;盖中间有进液通道(101)、排气或负压吸引通道(102)。其辅助粉碎刺(105)的主要用途之一,在于如辅助将容纳采集的固体粪便块机械粉碎。所以,优选结合外部振动、晃动、挤压质软的悬浮液容器(100)外周,或内部辅助搅拌的力量,以便易于将粪便团制成悬液。The inner wall of the suspension container (100) is provided with auxiliary crushing thorns (105) for mixing, stirring and crushing the contents of the cavity. The auxiliary crushing thorns (105) are sharp-edged nails, pieces, and rib-like structures. Geometric structures with sharp edges such as triangular prisms, blade-like shapes, and pointed cones can be added. The appearance of the suspension container (100) can be a drum, a flat bucket, a cube, a cuboid and irregular shapes, and the appearance of the preferred mixing structure is drum-shaped, with a depth of 15.0 cm, an upper opening diameter of 8.0 cm, and a cover; There are liquid inlet channel (101), exhaust or negative pressure suction channel (102). One of the main purposes of its auxiliary pulverizing thorn (105) is to mechanically pulverize the solid feces block that holds collection. Therefore, it is preferable to combine external vibration, shaking, squeezing the periphery of the soft suspension container (100), or internal auxiliary stirring force, so as to easily make the feces mass into a suspension.
所述悬浮液容器(100)外壳设有用于闭塞各管道的活塞样假体(106)。The housing of the suspension container (100) is provided with a piston-like prosthesis (106) for occluding each pipeline.
如图2所示,所述逐级过滤装置(200)为在悬浮液容器(100)内设至少1个过滤网(104),所述过滤网(104)的形状可在此悬浮容器(100)内设计为开口向上的倒梯形条状槽,倒梯形条状槽表面为滤网结构;所述悬浮液容器(100)的上部侧面一侧开口供倒梯形条状槽水平插入,通过卡合或螺旋的方式定位形成密闭结构。这种形式的过滤网(104)如“抽屉”样的结构可以方便插入和取出,还可设有手柄。所述悬浮液容器(100)内设有1个以上过滤网(104)时,按照滤孔直径从大到小的次序,自上而下设置2-10个过滤网(104)连续叠置在一起,各过滤网(104)过滤孔直径在5.0mm–0.001mm之间选择。依据临床实际过滤的需求,优选将各级过滤部件大小、形状完全相同,仅滤网孔径不同,方便置换不同孔径的滤网,或者利用假体过滤部件(无过滤网或者无过滤意义的大直径过滤网)置换以减少过滤层次。该设计可以满足特定滤孔直径的滤网收集目的成分。As shown in Figure 2, the step-by-step filtering device (200) is to set at least one filter screen (104) in the suspension container (100), and the shape of the filter screen (104) can be suspended in the suspension container (100) ) is designed as an inverted trapezoidal strip groove with an upward opening, and the surface of the inverted trapezoidal strip groove is a filter screen structure; one side of the upper side of the suspension container (100) is open for the horizontal insertion of the inverted trapezoidal strip groove, and the Or helically positioned to form a closed structure. The filter screen (104) of this form can be conveniently inserted and taken out as a "drawer" like structure, and can also be provided with a handle. When more than one filter screen (104) is provided in the suspension container (100), 2-10 filter screens (104) are continuously stacked on top of each other according to the order of filter hole diameters from large to small. Together, the filter hole diameters of the filter screens (104) are selected between 5.0mm-0.001mm. According to the actual clinical filtration requirements, it is preferable to have the same size and shape of the filter components at all levels, only the filter pore size is different, so that it is convenient to replace the filter screens with different pore sizes, or use prosthetic filter components (without filter screen or large diameter without filtering meaning) filter) replacement to reduce the filter level. The design can meet the specific filter hole diameter of the filter to collect the purpose components.
所述过滤网(104)的过滤孔直径在5.0mm–0.001mm之间,按照滤孔直径从大到小的次序,自上而下设置1-10个过滤网(104)。不同滤孔直径的过滤网(104)可以共位于悬浮液容器(100)中,该容器内至少设一级过滤结构,其过滤网(104)滤孔直径最大5mm。优选在悬浮液容器(100)桶壁下段、距离底部1cm处设置过滤网(104),滤网孔直径优选3mm,该滤网正面优选设有10个边缘锐利、高0.5cm的三棱柱。结合混匀容器外部的自动或手动的振荡作用,将粪便制成悬液,并充分分离附属的细菌、虫卵等成分进入悬液,以用于过滤。不断的混匀过程对维持良好的过滤状态非常重要,尤其对于存在不同固体成分悬液非常重要,充分混匀的条件,不仅对于第一级混悬过滤重要,对第二、第三等过滤级装置及其内部的悬液,一样重要。The filter hole diameter of the filter screen (104) is between 5.0mm-0.001mm, and 1-10 filter screens (104) are arranged from top to bottom according to the order of filter hole diameter from large to small. Filter screens (104) with different filter hole diameters can be co-located in the suspension container (100), and at least one level of filter structure is arranged in the container, and the maximum filter hole diameter of the filter screen (104) is 5mm. Preferably, a filter screen (104) is set at the lower part of the barrel wall of the suspension container (100), 1 cm from the bottom, the filter screen hole diameter is preferably 3 mm, and the front of the filter screen is preferably provided with 10 triangular prisms with sharp edges and a height of 0.5 cm. Combined with the automatic or manual oscillation outside the mixing container, the stool is made into a suspension, and the attached bacteria, eggs and other components are fully separated into the suspension for filtration. The continuous mixing process is very important to maintain a good filtration state, especially for the suspension of different solid components. The condition of sufficient mixing is not only important for the first stage suspension filtration, but also for the second and third filtration stages. The device, and the suspension within it, are just as important.
以临床最需要的获得大量寄生虫和粪菌液为例,依据过滤的先后至少分为2–3层:较大直径的食物残渣、未被充分匀浆的小粪团块及寄生虫残片,需要通过第一级过滤网(104)滤除,过滤孔的直径为3.0mm–4.0mm;如果以获得寄生虫卵为目的,则在接下来第二级过滤选择2.0mm过滤孔基础上,进一步通过第三级过滤,过滤孔为0.8mm,虫卵则位于该0.8mm层次的过滤网(104)上。如果还需要进一步需要获得大量的细菌,而同时也需要滤除寄生虫,避免在粪菌移植过程中导致寄生虫感染,因为大部分细菌长度不超过50μm,宽度不超过1μm,所以,需要将孔径设计为0.05mm–0.1mm。这种多级过滤的方法,能高效获得大量的菌液,去除黄色成分,降低菌液的粘滞度,达到无臭味的程度。相反,如果在粪便悬浮液制成之后,直接使用0.1mm直径的过滤孔过滤,将会使得大量的悬浮物颗粒成分堵塞在虑筛之上,大量细菌附属于这些固体成分或者堵塞的空间,导致收获的细菌数量明显减少。如果是获取经过内镜切取的细碎组织,患者之前已经清洁肠道,经内镜抽吸物之中的较大直径粪便很少,所以,一般只需要1层滤孔直径在1.0mm–2.0mm左右的滤网结构,即可有效获得在滤网上存留的组织标本。Taking the obtaining of a large number of parasites and fecal bacteria fluids that are most needed clinically as an example, it can be divided into at least 2-3 layers according to the order of filtration: food residues with larger diameters, small fecal clumps that have not been fully homogenized, and parasite fragments. It needs to be filtered out by the first-stage filter screen (104), and the diameter of the filter hole is 3.0mm-4.0mm; if it is the purpose to obtain parasite eggs, then on the basis of selecting 2.0mm filter holes for the next second-stage filter, further Through the third stage of filtration, the filter hole is 0.8mm, and the eggs are located on the filter screen (104) of this 0.8mm level. If it is necessary to further obtain a large number of bacteria, it is also necessary to filter out parasites to avoid parasite infection during fecal bacteria transplantation, because most bacteria are no more than 50 μm in length and 1 μm in width, so the pore size needs to be adjusted Designed for 0.05mm–0.1mm. This multi-stage filtration method can efficiently obtain a large amount of bacterial liquid, remove yellow components, reduce the viscosity of the bacterial liquid, and achieve an odor-free level. On the contrary, if the fecal suspension is directly filtered through a filter hole with a diameter of 0.1 mm, a large amount of suspended solid particles will be blocked on the filter screen, and a large number of bacteria will be attached to these solid components or the blocked space, resulting in The number of bacteria harvested was significantly reduced. If the finely divided tissue is obtained through endoscopy, the patient’s intestines have been cleaned before, and there are very few large-diameter feces in the endoscopic aspiration, so generally only one layer of filter holes with a diameter of 1.0mm–2.0mm is required The left and right filter mesh structure can effectively obtain tissue samples retained on the filter mesh.
如图1所示,所述逐级过滤装置(200)还可以为在悬浮液容器(100)之外还设置有至少1个副悬浮液容器(107),副悬浮液容器(107)优选为“顶园底平”的容器结构,即由上下两个结构通过螺旋纹吻合而成的密闭结构,吻合口直径为5.0cm,工作状态时为上下完全吻合;上方为半球形盖样结构,深度为4.0cm,顶部连通来自上一级过滤之后的排液通道(103),该管道在超过盖顶内表面1.0cm,盖顶上方还有一个排气或负压吸引通道(102),位于盖顶外表面有2个活塞样假体(106)用于闭塞液体引入和负压吸引的软管开口;下方为平底圆桶状结构,深度为8.0cm,在其距离螺旋吻合口2.0cm的位置,在壁上有一过滤网(104),该过滤网的直径在第二级、第三级和第四级优选分别为2.0mm、0.8mm和0.08mm;出液管道开口于过滤网(104)下方、容器的底部,连通至过滤容器腔外;各级过滤装置通过可曲软管(108)连通,相互并行直立,连通管中间具有连接结构,可以减少或者更换其中任何一级过滤结构。可以通过取出并旋开任何一级的过滤球形装置,可获取滤网上相应直径以上的固体成分。As shown in Figure 1, the step-by-step filtering device (200) can also be provided with at least one auxiliary suspension container (107) outside the suspension container (100), and the auxiliary suspension container (107) is preferably The container structure of "top garden and flat bottom" is a closed structure formed by joining the upper and lower structures through spiral patterns. The diameter of the anastomosis is 5.0cm, and the upper and lower sides are completely matched in the working state; the upper part is a hemispherical cover-like structure, and the depth It is 4.0cm, and the top is connected with the drainage channel (103) from the upper stage of filtration. This pipeline is 1.0cm beyond the inner surface of the top of the cover. There is also an exhaust or negative pressure suction channel (102) above the top of the cover, which is located There are 2 piston-like prostheses (106) on the outer surface of the top for occlusion of the hose opening for liquid introduction and negative pressure suction; the bottom is a flat-bottomed cylindrical structure with a depth of 8.0 cm, at a position 2.0 cm away from the spiral anastomosis , a filter screen (104) is arranged on the wall, and the diameter of this filter screen is preferably respectively 2.0mm, 0.8mm and 0.08mm at the second stage, the third stage and the fourth stage; the liquid outlet pipe is opened in the filter screen (104) The lower part, the bottom of the container, is connected to the outside of the filter container cavity; the filter devices of all levels are connected through flexible hoses (108), and stand parallel to each other. There is a connecting structure in the middle of the connecting pipes, which can reduce or replace any one of the filter structures. The solid components above the corresponding diameter on the filter can be obtained by taking out and unscrewing the filter spherical device of any stage.
副悬浮液容器(107)同样至少设有1个进液通道(101)、1个排气或负压吸引通道(102)、1个排液通道(103),所述副悬浮液容器(107)底部为设有坡面帮助液体由1个排液通道(103)流出,悬浮液容器(100)和副悬浮液容器(107)内部各设有至少1个过滤网(104),所述过滤网(104)的形状为平面网状结构。The secondary suspension container (107) is also at least provided with 1 liquid inlet channel (101), 1 exhaust or negative pressure suction channel (102), 1 liquid discharge channel (103), and the secondary suspension container (107 ) bottom is provided with a slope to help the liquid flow out from a liquid discharge channel (103), and at least one filter screen (104) is respectively provided inside the suspension container (100) and the auxiliary suspension container (107). The shape of the net (104) is a planar mesh structure.
所述悬浮液容器(100)内设有1个以上过滤网(104)时,按照滤孔直径从大到小的次序,自上而下设置2-10个过滤网(104),各过滤网(104)过滤孔直径在5.0mm–0.001mm之间选择。When the suspension container (100) is provided with more than one filter screen (104), according to the order of filter hole diameter from large to small, 2-10 filter screens (104) are arranged from top to bottom, each filter screen (104) The diameter of the filter hole is selected between 5.0mm-0.001mm.
所述副悬浮液容器(107)同时设置有1个以上时,各副悬浮液容器(107)通过可曲软管(108)连通。When more than one auxiliary suspension container (107) is provided at the same time, each auxiliary suspension container (107) is connected through a flexible hose (108).
本发明的一种医用腔道内容物目标成分回收器械,具有目标成分收集装置(300),目标成分收集装置(300)至少具有1个进液通道(101)、1个排气或负压吸引通道(102),内设有或者不设有过滤网(104)。目标成分的收集位置,取决于目的成分是固体还是液体。如果是固体,收集目的成分的位置决定于其直径,收集目的成分的位置为相应层次的过滤网(104),位置优选同前述第二级及其之后的过滤结构所处的位置,便于加工。优选设计为过滤装置可以取出或者更换。如果是液体或者位于液体中,如肠道菌群悬液和脱落细胞悬液,收集装置则为用液体收集容器,该装置优选具有满足负压吸引的连接装置,可以采用常用的负压吸引瓶设计。对于液体收集容器,可以附加自行封闭开口用于保存的辅助设施。A device for recovering target components of the contents of a medical cavity according to the present invention has a target component collection device (300), and the target component collection device (300) has at least one liquid inlet channel (101), one exhaust or negative pressure suction The channel (102) is provided with or not provided with a filter screen (104). Where the target component is collected, depending on whether the target component is a solid or a liquid. If it is solid, the position of collecting the target component is determined by its diameter, and the position of collecting the target component is the filter screen (104) of the corresponding level, and the position is preferably the same as the position of the aforementioned second stage and the filtering structure thereafter, which is convenient for processing. It is preferably designed such that the filter device can be removed or replaced. If it is liquid or located in liquid, such as intestinal flora suspension and exfoliated cell suspension, the collection device is a liquid collection container, which preferably has a connection device that meets negative pressure suction, and a commonly used negative pressure suction bottle can be used design. For liquid collection containers, auxiliary facilities for self-closing openings for storage can be added.
实施例1Example 1
用于制备粪菌液和收集虫卵的实施例,如图1所示,为本发明的连续过滤层非共享同一容器的结构示意图。所述器械具有:The embodiment for preparing fecal liquid and collecting insect eggs, as shown in Figure 1, is a schematic structural diagram of the continuous filter layer of the present invention not sharing the same container. The device has:
(1)粪便混匀容器即悬浮液容器(100),为塑料成形桶或者塑料软桶,上部开口大,成形,开口直径为10.0cm,有盖;盖中间有进液通道(101)、排气或负压吸引通道(102);粪便混匀容器设有进液通道(101),管内径0.8cm,在于连通粪便匀浆、稀释的专用液体供给源,或者用于连接内镜抽吸孔道;桶的体部靠近底部的区域,设有边缘锐利的三棱样长度为0.5cm的辅助粉碎刺(105)结构,桶的底部有一过滤网(104)(即第一级过滤结构),过滤网(104)正面有边缘锐利的三棱样长度为0.5cm的辅助粉碎刺(105)结构,过滤网(104)固定在距离底部上方2.0cm的高度,容器内的底部为片心漏斗状,方便溶液向最低的位置,即输出管道开口处聚集;固定成形的混匀容通过器锐利的三棱柱结合混匀容器外部的振荡作用,将粪便制成悬液;塑料软桶通过边缘锐利的三柱结合外部的振荡作用,或者向桶体中间挤压的机械作用,将粪便粉碎并制成悬液。(1) The excrement mixing container is the suspension container (100), which is a plastic forming barrel or a plastic soft barrel, with a large opening on the upper part, shaped, and the diameter of the opening is 10.0 cm, with a cover; there is a liquid inlet channel (101) and a discharge channel Gas or negative pressure suction channel (102); the feces mixing container is provided with a liquid inlet channel (101), the inner diameter of which is 0.8 cm, which is used to connect the special liquid supply source for feces homogenization and dilution, or to connect the endoscope suction channel The body of the barrel is provided with an auxiliary crushing thorn (105) structure of 0.5cm in the area near the bottom of the triangular shape with sharp edges, and a filter screen (104) (i.e. the first stage filter structure) is arranged at the bottom of the barrel to filter The front of the net (104) has a triangular shape with sharp edges and an auxiliary crushing thorn (105) structure with a length of 0.5 cm. The filter screen (104) is fixed at a height of 2.0 cm above the bottom, and the bottom in the container is funnel-shaped. It is convenient for the solution to gather at the lowest position, that is, the opening of the output pipe; the fixed and shaped mixing container passes through the sharp triangular prism combined with the external oscillation of the mixing container to make the feces into a suspension; the plastic soft bucket passes through the sharp triangular prism The column combined with the external vibration action, or the mechanical action of squeezing to the middle of the barrel, pulverizes the feces and makes a suspension.
(2)排液通道(103)通过悬浮液容器(100)向外延伸,通过软管连接第二级逐级过滤装置(200)。持续混匀10-20分钟,即制成混悬液,结束时启动各级过滤,将第一级过滤之后的悬液引流进入第二级及其后续装置内,完成连续过滤。(2) The drainage channel (103) extends outward through the suspension container (100), and is connected to the second-stage progressive filtering device (200) through a hose. Continue mixing for 10-20 minutes to make a suspension. At the end of the process, each level of filtration is started, and the suspension after the first level of filtration is drained into the second level and its subsequent devices to complete continuous filtration.
(3)第二级、第三级、第四级逐级过滤装置(200)均为一个由上下两个结构通过螺旋纹吻合而成的密闭结构即副悬浮液容器(107),吻合口直径为5.0cm,工作状态时为上下完全吻合;上方为半球形盖样结构,深度为3.0cm,顶部连通来自上一级过滤之后输出的管道,该管道在超过盖顶内表面1.0cm,盖顶上方还有一个排气或负压吸引通道(102),位于盖顶外表面有2个活塞样假体(106)用于闭塞液体引入和负压吸引的软管开口;下方为圆桶状结构,深度为8.0cm,在其距离螺旋吻合口2.0cm的位置,在壁上固有一过滤网(104),该过滤网(104)的直径在第二级、第三级和第四级分别为2.0mm、0.8mm和0.08mm;排液通道(103)开口于过滤网(104)下方容器的底部,连通至过滤容器腔外;各级过滤装置通过可曲软管(108)连通,相互并行直立,连通管中间具有连接结构,可以减少或者更换其中任何一级过滤结构。(3) The second stage, the third stage, and the fourth stage filtering device (200) are all an airtight structure formed by anastomosis of the upper and lower structures through spiral patterns, that is, the secondary suspension container (107), and the diameter of the anastomosis is It is 5.0cm, and the top and bottom are completely consistent in the working state; the upper part is a hemispherical cover-like structure with a depth of 3.0cm, and the top is connected to the output pipeline from the upper stage of filtration. The pipeline exceeds the inner surface of the cover by 1.0cm. There is also an exhaust or negative pressure suction channel (102) on the top, and there are two piston-like prostheses (106) on the outer surface of the top of the cover to block the opening of the hose for liquid introduction and negative pressure suction; the bottom is a barrel-shaped structure , the depth is 8.0cm, at the position of 2.0cm away from the spiral anastomotic stoma, there is a filter screen (104) on the wall, the diameter of the filter screen (104) is respectively 2.0mm, 0.8mm, and 0.08mm; the drain channel (103) opens at the bottom of the container below the filter screen (104), and is connected to the outside of the filter container cavity; the filter devices at all levels are connected through flexible hoses (108), parallel to each other Upright, there is a connection structure in the middle of the connecting pipe, which can reduce or replace any one of the filter structures.
(4)可以通过取出并旋开任何一级的过滤球形装置,可获取过滤网(104)上相应直径以上的固体成分。(4) By taking out and unscrewing any one-stage filter spherical device, the solid components above the corresponding diameter on the filter screen (104) can be obtained.
(5)以上进出液管道的流体流通速度,可通过手动或者自动的程序控制进液的量、速度和时间;管材为一次性使用;软件相互之间采用螺旋或者弹性套入的方式连接。(5) The fluid flow rate of the above inlet and outlet pipes can be controlled by manual or automatic procedures to control the amount, speed and time of the inlet; the pipes are for one-time use; the software is connected with each other by spiral or elastic insertion.
(6)粪菌液收集装置即目标成分收集装置(300)为一个瓶装结构,经过以上步骤,在最后阶段收集到的粪菌液体已经几乎为无色、无味、透明的菌液;该收集容器的口部具有一个螺旋盖,螺旋盖中间具有2个连通管,分别用于进液和负压吸引排气;瓶盖的外面正上方还有2个锥形假体,用来塞闭可弯曲的进液管和负压吸引管。(6) The feces bacteria liquid collection device, that is, the target component collection device (300) is a bottled structure. Through the above steps, the feces bacteria liquid collected in the final stage is almost colorless, tasteless, transparent bacteria liquid; the collection container The mouth of the bottle has a screw cap, and there are two connecting pipes in the middle of the screw cap, which are respectively used for liquid intake and negative pressure suction exhaust; there are also two conical prostheses just above the outside of the bottle cap, which are used to block the bendable The liquid inlet tube and the negative pressure suction tube.
(7)瓶装收集容器作为收集粪菌液的目的之用时,一直处于直立状态下使用,进液通道(101)在瓶盖外延长连接过滤装置,在内部向瓶底方向延伸约2.0cm;而负压吸引管在瓶内仅与瓶盖内面齐平。(7) When the bottled collection container is used as the purpose of collecting the feces liquid, it is used in an upright state, and the liquid inlet channel (101) is extended outside the bottle cap to connect the filter device, and extends about 2.0cm toward the bottom of the bottle inside; and The negative pressure suction tube is only flush with the inner surface of the bottle cap in the bottle.
(8)该收集瓶如果倒立,则用于粪菌液输注使用,此时,负压排气的管道用于输出,而原来进液的管道则成为向瓶内加压或者进气的管道。(8) If the collection bottle is turned upside down, it will be used for the infusion of fecal bacteria liquid. At this time, the pipeline for negative pressure exhaust is used for output, and the original pipeline for liquid inlet becomes the pipeline for pressurizing or air intake into the bottle .
(9)瓶装收集容器的螺旋盖可用等口径无管配置的螺旋盖置换,瓶的容积为500ml,瓶身有正反双向的体积刻度;瓶的材料用医用输液瓶的透明塑料,优选淡蓝色,可以避光,减少对细菌的作用,同时,在视觉上给工作人员和患者均留下美好的感觉。(9) The screw cap of the bottled collection container can be replaced by a screw cap with equal diameter and no tube configuration. The volume of the bottle is 500ml, and the body of the bottle has volume scales in both positive and negative directions; the material of the bottle is the transparent plastic of a medical infusion bottle, preferably light blue The color can avoid light and reduce the effect on bacteria. At the same time, it leaves a good feeling for both staff and patients visually.
(10)以上使用器械均为一次性用品,可全部用塑料制成。(10) The above-mentioned instruments are all disposable and can be made of plastic.
实施例2Example 2
用于制备粪菌液和收集虫卵的实施例,如图2、3所示,关键在于是一种“抽屉”样过滤层共享同一容器。所述器械具有:For the embodiment of preparing fecal liquid and collecting worm eggs, as shown in Figures 2 and 3, the key is that a kind of "drawer" like filter layer shares the same container. The device has:
(1)粪便混匀容器即悬浮液容器(100)设有进液通道(101),管内径0.8cm,在于连通粪便匀浆、稀释的专用液体供给源,或者用于连接内镜抽吸孔道。该通道可通过手动或者自动的程序控制进液的量、速度和时间。优选一次性塑料软管,管内径5.0mm,软管端口设计优选螺旋或者弹性套入。(1) The feces mixing container, that is, the suspension container (100) is provided with a liquid inlet channel (101) with an inner diameter of 0.8 cm, which is used to connect to the special liquid supply source for feces homogenization and dilution, or to connect to the suction channel of the endoscope . The channel can control the amount, speed and time of feeding through manual or automatic procedures. Disposable plastic hose is preferred, the inner diameter of the tube is 5.0mm, and the design of the hose port is preferably spiral or elastic sleeve.
(2)悬浮液容器(100)内设有第一层过滤结构为大直径过滤孔,该过滤网(104)的直径为4.0mm,滤筛上具有直立的6条交错布置的、高5mm的、边缘锐利的三棱柱状辅助粉碎刺(105),结合在容器外部的机械震荡力量,共同辅助粉碎粪团,并经过充分冲洗,分离附属在残渣上的细菌、虫卵等成分进入悬液,(2) The suspension container (100) is provided with a first layer of filter structure which is a large-diameter filter hole. The diameter of the filter screen (104) is 4.0mm, and there are 6 upright staggered, 5mm high filter screens on the filter screen. , the triangular prism-shaped auxiliary crushing thorns (105) with sharp edges, combined with the mechanical vibration force outside the container, jointly assist in crushing the feces, and through sufficient washing, the bacteria and insect eggs attached to the residue are separated into the suspension,
(3)悬浮液容器(100)之外具有一3层连续过滤结构的容器即副悬浮液容器(107),过滤孔的直径分别为4.0mm、2.0mm、0.8mm和0.08mm。(3) There is a container with a 3-layer continuous filter structure outside the suspension container (100), namely the auxiliary suspension container (107), and the diameters of the filter holes are 4.0mm, 2.0mm, 0.8mm and 0.08mm respectively.
(4)3层过滤结构为可以连续叠加的“抽屉样”结构,工作状态为直立位置。全部位于悬浮液容器之外的过滤容器中。设有1个进液通道(101)、1个排气或负压吸引通道(102),底部设有1个排液通道(103)。各个过滤部件制成倒梯形,如“抽屉”样的结构则以方便插入和取出更换,还设有手柄,即所述过滤网(104)的形状为开口向上的倒梯形条状槽,倒梯形条状槽表面为滤网结构;所述悬浮液容器(100)的上部侧面开口供倒梯形条状槽插入,通过卡合或螺旋的方式定位形成密闭结构。各级过滤部件按照滤孔直径从大到小的顺序,从上往下连续叠置在一起。依据临床实际过滤的需求,优选将各级过滤部件大小、形状完全相同,仅滤网孔径不同,方便置换不同孔径的滤网,或者利用假体过滤部件(无过滤网或者无过滤意义的大直径过滤网)置换以减少过滤层次。该设计可以满足特定滤孔直径的滤网收集目的成分。(4) The 3-layer filter structure is a "drawer-like" structure that can be stacked continuously, and the working state is in an upright position. All in a filter vessel outside of the suspension vessel. It is provided with a liquid inlet channel (101), an exhaust or negative pressure suction channel (102), and a liquid discharge channel (103) at the bottom. Each filter part is made into an inverted trapezoid, and the structure like a "drawer" is convenient for insertion and removal, and a handle is also provided, that is, the shape of the filter screen (104) is an inverted trapezoidal strip groove with an upward opening, and an inverted trapezoidal The surface of the strip-shaped groove is a filter mesh structure; the upper side opening of the suspension container (100) is inserted into the inverted trapezoidal strip-shaped groove, and is positioned to form an airtight structure by snapping or spiraling. Filter components at all levels are stacked together continuously from top to bottom according to the order of filter hole diameters from large to small. According to the actual clinical filtration requirements, it is preferable to have the same size and shape of the filter components at all levels, only the filter pore size is different, so that it is convenient to replace the filter screens with different pore sizes, or use prosthetic filter components (without filter screen or large diameter without filtering meaning) filter) replacement to reduce the filter level. The design can meet the specific filter hole diameter of the filter to collect the purpose component.
(5)第二层次滤孔直径为2mm,层高1.5cm。(5) The diameter of the filter hole of the second layer is 2mm, and the layer height is 1.5cm.
(6)第三层次滤孔直径为0.8mm的过滤,在于在该层面获取虫卵,层高1.5cm。(6) The filter hole diameter of the third layer is 0.8mm, which is to obtain insect eggs at this layer, and the layer height is 1.5cm.
(7)第四层次滤孔直径为0.08mm的过滤,是进一步取出粪液中悬浮的细微颗粒,去除黄色有形成分,在降低菌液的粘滞度同时,获得大量的清洁度高的菌液,层高1.5cm。(7) The fourth level of filtration with a filter hole diameter of 0.08mm is to further remove the fine particles suspended in the feces, remove the yellow formed components, and obtain a large number of bacteria with high cleanliness while reducing the viscosity of the bacteria liquid. Liquid, layer height 1.5cm.
(8)菌液经过排液通道(103)进入另一个瓶装收集容器即目标成分收集装置(300),实验结果证明,用500ml匀浆200g成型粪便,经过以上步骤,在最后阶段收集到的粪菌液体已经几乎为无色、无味、透明的菌液;该目标成分收集装置(300)的口部具有一个螺旋盖,螺旋盖中间具有2个连通管,分别用于进液和负压吸引排气;瓶盖的外面正上方还有2个锥形假体,用来塞闭可弯曲的进液管和负压吸引管。(8) Bacterial fluid enters another bottled collection container, i.e. the target component collection device (300), through the drainage channel (103). Experimental results prove that, with 500ml homogenate 200g molding feces, through the above steps, the feces collected in the final stage The bacterial liquid is almost colorless, odorless, transparent bacterial liquid; the mouth of the target component collecting device (300) has a screw cap, and there are 2 connecting pipes in the middle of the screw cap, which are respectively used for liquid inlet and negative pressure suction discharge. There are also 2 conical prostheses directly above the outside of the bottle cap, which are used to block the flexible liquid inlet tube and negative pressure suction tube.
(9)瓶装收集容器即目标成分收集装置(300)作为收集粪菌液的目的之用时,一直处于直立状态下使用,进液管在瓶盖外延长连接过滤装置,在内部向瓶底方向延伸约2.0cm;而负压吸引管在瓶内仅与瓶盖内面齐平。(9) When the bottled collection container, that is, the target component collection device (300) is used as the purpose of collecting the fecal liquid, it is used in an upright state, and the liquid inlet pipe is extended outside the bottle cap to connect to the filter device, and extends to the bottom of the bottle inside. About 2.0cm; while the negative pressure suction tube is only flush with the inner surface of the bottle cap in the bottle.
(10)该收集瓶如果倒立,则用于粪菌液输注使用,此时,负压排气的管道用于输出,而原来进液的管道则成为向瓶内加压或者进气的管道。(10) If the collection bottle is turned upside down, it will be used for the infusion of fecal bacteria liquid. At this time, the pipeline for negative pressure exhaust is used for output, and the original pipeline for liquid inlet becomes the pipeline for pressurizing or air intake into the bottle .
(11)瓶装收集容器的螺旋盖可用等口径无管配置的螺旋盖置换,瓶的容积为500ml,瓶身有正反双向的体积刻度;瓶的材料用医用输液瓶的透明塑料,优选淡蓝色,可以避光,减少对细菌的作用,同时,在视觉上给工作人员和患者均留下美好的感觉。(11) The screw cap of the bottled collection container can be replaced by a screw cap with equal caliber and tubeless configuration. The volume of the bottle is 500ml, and the body of the bottle has volume scales in both positive and negative directions; the material of the bottle is the transparent plastic of a medical infusion bottle, preferably light blue The color can avoid light and reduce the effect on bacteria. At the same time, it leaves a good feeling for both staff and patients visually.
(12)以上使用器械均为一次性用品,可全部用塑料制成。(12) The above-mentioned instruments are all disposable, and all of them can be made of plastic.
虽然在这里通过某个或某些特殊配置描述和阐明本发明,然而其目的并不在于限制所述细节,因为可能在专利要求范围内有各种修改和结构变更,并不偏离发明精神。Although the invention has been described and illustrated herein in terms of one or some specific configurations, it is not intended to be limited to such details, since various modifications and structural changes are possible within the scope of the patent claims without departing from the spirit of the invention.
本发明涉及部分均与现有技术相同或可采用现有技术加以实现。The parts involved in the present invention are the same as the prior art or can be realized by adopting the prior art.
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