CN103315749B - Skin area positioning device, method and system applicable to blood glucose detection - Google Patents
Skin area positioning device, method and system applicable to blood glucose detection Download PDFInfo
- Publication number
- CN103315749B CN103315749B CN201310210400.0A CN201310210400A CN103315749B CN 103315749 B CN103315749 B CN 103315749B CN 201310210400 A CN201310210400 A CN 201310210400A CN 103315749 B CN103315749 B CN 103315749B
- Authority
- CN
- China
- Prior art keywords
- skin area
- skin
- oct
- blood sugar
- lower plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008280 blood Substances 0.000 title claims abstract description 81
- 210000004369 blood Anatomy 0.000 title claims abstract description 81
- 238000000034 method Methods 0.000 title claims description 37
- 238000001514 detection method Methods 0.000 title abstract description 17
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract description 14
- 239000008103 glucose Substances 0.000 title abstract description 14
- 239000000523 sample Substances 0.000 claims abstract description 28
- 238000012545 processing Methods 0.000 claims abstract description 10
- 239000002390 adhesive tape Substances 0.000 claims abstract description 9
- 238000012360 testing method Methods 0.000 claims description 54
- 230000008569 process Effects 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- 230000002093 peripheral effect Effects 0.000 claims description 7
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 230000011218 segmentation Effects 0.000 claims description 4
- 238000012014 optical coherence tomography Methods 0.000 abstract description 86
- 238000005516 engineering process Methods 0.000 abstract description 5
- 238000000605 extraction Methods 0.000 abstract description 5
- 230000008859 change Effects 0.000 description 14
- 210000001519 tissue Anatomy 0.000 description 13
- 238000010586 diagram Methods 0.000 description 7
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000003292 glue Substances 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 230000011514 reflex Effects 0.000 description 4
- 241000168254 Siro Species 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000009987 spinning Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention relates to a skin area positioning device applicable to blood glucose detection. The skin area positioning device applicable to the blood glucose detection comprises an OCT (optical coherence tomography) detection probe, an upper plate and a lower plate. The bottom of the lower plate is connected with double-faced adhesive tapes and a fastening belt, the lower plate is provide with a rectangular window area, and the upper plate is provided with a through hole communicated with the rectangular window area. The lower plate is tightly adhered to a skin to be detected through the double-faced adhesive tapes and the fastening belt, the rectangular window area is used for determining a skin area to be detected, and the OCT detection is used for scanning the skin area to be detected and other areas. The skin area positioning device applicable to the blood glucose detection can position the skin area to be detected. Besides, the invention also provides a skin area extraction method for the blood glucose detection to further achieving the automatic extraction of the skin area to be detected. Meanwhile, the invention provides a skin area positioning system applicable to the blood glucose detection. After the skin area positioning device applicable to the blood glucose detection positions the skin area to be detected preliminarily, a computer achieves the automatic extraction of the skin area to be detected through an image processing technology.
Description
Technical field
The present invention relates to measurement of blood sugar concentration field, particularly relate to a kind of the skin area positioner, method and the system thereof that are applied to blood sugar test.
Background technology
Diabetes are frequently-occurring diseases of mid-aged population, and along with the raising of people's living standard, the sickness rate of diabetes also rises day by day, and diabetes, tumor are classified as worldwide three disaster diseases by World Health Organization (WHO) together with cardiovascular and cerebrovascular disease.Find a kind of method that blood sugar concentration detects the prevention and therapy of diabetes is had very great significance.Current blood sugar concentration detection method is most widely used is have wound to measure.The method having wound to detect main application relies on electrochemical method to refer to that blood detects the blood glucose concentration value obtaining patient to patient.The method can realize detecting the blood glucose concentration value in a certain moment, but equally also there are some shortcomings.Such as, extraction refers to that blood is more painful, measure blood sugar concentration and needs consumptive material etc.Also have some Wicresoft's detection methods in addition, Wicresoft's detection method mainly detects blood sugar concentration by detecting the tissue fluid extracted from skin, and the method can alleviate the misery of patient, but causes certain wound to patient equally.In sum, the device of Non-invasive detection blood sugar concentration and correlation method are highly significant.
Research shows, utilizes optical means can detect the corresponding relation of the intensity of the light of returning from skin reflex and the scattering coefficient of skin histology, and the inner blood glucose concentration value of the scattering coefficient of skin histology and biological tissue is closely related.Following single scattered light strength formula can the corresponding relation of the approximate description intensity of light of returning from skin reflex and the scattering coefficient of skin histology:
I
R＝I
oexp[-(μ
a+μ
s)L]
Wherein I
rfor the light intensity of returning from skin reflex, I
ofor projecting the light intensity of skin, μ
afor the absorptance of skin histology, μ
sfor the scattering coefficient of skin histology, L is the total optical path of light transdermal.As can be seen from the above equation, the intensity of the light of returning from skin reflex is the exponential damping with scattering coefficient and absorptance.
In skin histology, the refractive index of body fluid and the refractive index of organelle there are differences.This difference can cause skin histology to scattering of light phenomenon.Glucose is the main ingredient of of body fluid, and when blood sugar concentration changes, the refractive index of body fluid also can change thereupon, and this can cause tissue scatter's coefficient to change.At near infrared band, the scattering coefficient change that glucose causes wants the change of specific absorptivity much bigger, and therefore the change of blood sugar concentration mainly causes the change of skin histology scattering coefficient instead of the change of absorptance.As can be seen here, optical detection skin histology scattering coefficient can as of a noninvasive dynamics monitoring important means.
Skin histology is from organizational structure, comprise a lot of sweat glands, oils and fats gland and blood vessel, these organizational structuries are very strong for the absorption of infrared light, therefore at use OCT(Optical Coherence Tomography, optical coherence tomography) when gathering relevant to skin histology data, can very weak or disappearance at these organizational structure regional signals.When making optically to carry out blood glucose concentration value detection, need to consider that these strong absorptive tissue parts are on the impact on blood sugar test precision of whole signal.Can find out, ensure to detect in OCT noninvasive dynamics monitoring process skin histology position remain unchanged effectively can reduce organization internal structure change at random on the impact of OCT signal, thus improve the precision and stability that blood glucose concentration value detects.
In addition, in OCT noninvasive dynamics monitoring process, the movement of human body can cause the position of detected skin area to change.Such as, in long-time blood sugar test process, slight movement due to human body itself makes OCT measuring probe and tested specific region of skin generation relative position move, the movement of this kind of relative position is included in the high and low position change of vertical skin surface direction, and changes at the relative position of the front and back of skin surface and left and right directions.The movement of these relative positions can make the organizational structure in detection of skin region change, thus causes corresponding optical parametric to change, and finally causes the measured value of noninvasive dynamics monitoring to occur error.
For the problem of skin histology internal structure random distribution, the mode that present stage generally adopts uses OCT three-dimensional data on average to obtain skin histology one-dimensional signal in the depth direction in the horizontal direction, then obtain the scattering coefficient of skin histology inside by one-dimensional signal.Although average operation can eliminate the stochastic behaviour impact of skin texture effectively, but when the skin area being used for blood sugar test is not in same position, there is very large difference in one-dimensional signal, this can badly influence the precision and stability that blood sugar concentration detects equally.In order to ensure that tested skin area remains unchanged in OCT Woundless blood sugar concentration value testing process, there is researcher, in OCT measuring probe front portion, a disk and contact skin are installed, and apply certain pressure OCT measuring probe is fixed on skin.Although this device can keep keeping fixing between OCT measuring probe and skin, but ensure that skin and OCT measuring probe position remain unchanged due to certain pressure will be applied to detected skin area, this also can change skin histology inner structural features, also can have influence on the microcirculation of skin area to be measured local simultaneously, final blood sugar concentration accuracy of detection and stability can be had influence on further.
Summary of the invention
Based on this, be necessary to provide a kind of the skin area positioner being applied to blood sugar test, method and the system thereof that can improve the precision and stability that blood sugar concentration detects.
A kind of skin area positioner being applied to blood sugar test, comprise OCT measuring probe, upper plate and be connected to the lower plate of described upper plate, described upper plate is connected to described OCT measuring probe, double faced adhesive tape and cingulum is connected with bottom described lower plate, and described lower plate offers rectangle windows district, described upper plate offers and is communicated with described rectangle and windows the through hole in district; Described lower plate is close to skin to be measured by double faced adhesive tape and cingulum, and described rectangle windows district for determining skin area to be measured, and described OCT measuring probe is for scanning skin to be measured and peripheral region thereof.
Wherein in an embodiment, described upper plate is connected with screw lock by alignment pin location with lower plate.
Wherein in an embodiment, the window surrounding in district of described rectangle is ramp structure.
Wherein in an embodiment, described rectangle district of windowing is of a size of long 0.5mm ~ 30mm, wide 0.5mm ~ 30mm.
Wherein in an embodiment, the window surrounding in district of described rectangle is ramp structure.
Wherein in an embodiment, the window surrounding in district of described rectangle is coated with near-infrared absorption medium.
Wherein in an embodiment, described upper plate and lower plate are one piece of thin plate, and the middle part of described thin plate offers rectangle windows district.
Wherein in an embodiment, the material of described thin plate is near-infrared absorption material.
A kind of skin area navigation system being applied to blood sugar test, comprise above-mentioned the skin area positioner, OCT system and the computer that are applied to blood sugar test, the described OCT measuring probe being applied to the skin area positioner of blood sugar test is connected to described OCT system, and described OCT system is connected to described computer; Described OCT system scans the three-dimensional OCT image of intensity collection of the reflected light that skin to be measured and peripheral region thereof obtain according to described OCT measuring probe, and described computer is used for three-dimensional OCT image described in analyzing and processing.
Use is applied to the skin area extracting method being applied to blood sugar test of the skin area positioner of blood sugar test, comprises the steps:
Skin area to be measured is determined with being provided with the window lower plate in district of rectangle;
Upper plate is connected with lower plate, fixes upper plate and lower plate simultaneously;
Gather and at least comprise rectangle and to window the three-dimensional OCT image of the human body skin below district;
The three-dimensional OCT image comprising human skin tissue is processed, skin area to be measured is extracted automatically.
Wherein in an embodiment, processing at the described three-dimensional OCT image to comprising human skin tissue, positioning in step to skin area to be measured, comprising the steps:
The three-dimensional OCT image comprising human skin tissue is projected in the depth direction, calculates the meansigma methods comprising the three-dimensional OCT image light intensity of human skin tissue, obtain two-dimensional projection image;
Adopt the noise jamming in median filtering algorithm removal two-dimensional projection image;
Adopt Da-Jin algorithm to split filtered two-dimensional projection image, obtain skin area and non-skin region;
The process of morphology opening operation is carried out to the two-dimensional projection image after segmentation;
According to the XY coordinate of skin area determination skin area in three-dimensional OCT image obtained in described step (3), and extract three-dimensional OCT skin image in three-dimensional OCT image.
The above-mentioned skin area positioner being applied to blood sugar test, can ensure that skin area position to be measured is substantially fixing, realize the object of locating skin area to be measured.In addition, additionally provide a kind of skin area extracting method being applied to blood sugar test, first by lower plate and detected skin area compact siro spinning technology, then upper plate is connected to lower plate, thus ensure that skin area position to be measured is substantially fixing.Secondly the three-dimensional OCT image comprising the human body skin that rectangle is windowed below district collected is processed, further skin area to be measured is extracted automatically, thus the precision and stability that blood sugar concentration is detected is higher.Also provided is a kind of skin area navigation system being applied to blood sugar test, after the skin area positioner being applied to blood sugar test is to skin area Primary Location to be measured, computer is utilized to adopt image processing techniques to carry out precisely extracting further to skin area to be measured.
Accompanying drawing explanation
Fig. 1 is the structural representation being applied to the skin area positioner of blood sugar test of an embodiment;
Fig. 2 is the upper plate of skin area positioner being applied to blood sugar test and the structural representation of lower plate of an embodiment;
Fig. 3 is the structural representation being applied to the lower plate of the skin area positioner of blood sugar test of an embodiment;
Fig. 4 is the flow chart being applied to the skin area extracting method of blood sugar test of an embodiment;
Fig. 5 is the schematic diagram that the skin area positioner being applied to blood sugar test of an embodiment is connected with human body skin, OCT system and computer when reality uses;
Fig. 6 is after the OCT measuring probe of an embodiment scans lower plate, the schematic diagram of the three-dimensional OCT image that OCT system acquisition arrives;
Fig. 7 is that the three-dimensional OCT image of an embodiment projects in the depth direction and obtains the schematic diagram of two-dimensional projection image;
Fig. 8 is the schematic diagram of the two-dimensional projection image after the employing medium filtering of an embodiment;
Fig. 9 be an embodiment to after filtering two-dimensional projection image use Da-Jin algorithm split the segmentation image schematic diagram obtained;
Figure 10 is the schematic diagram of image after the morphology opening operation process of an embodiment;
Figure 11 is the schematic diagram of the three-dimensional OCT image collected after skin area extracting method that the utilization of an embodiment is applied to blood sugar test extracts automatically to skin area to be measured.
Detailed description of the invention
In order to the problem that the method solving current Woundless blood sugar measurement of concetration is not high to skin area positioning precision to be measured, present embodiments provide for a kind of the skin area positioner, method and the system thereof that are applied to blood sugar test.Below in conjunction with specific embodiment, be specifically described being applied to the skin area positioner of blood sugar test, method and system thereof.
Please refer to Fig. 1, the skin area positioner of blood sugar test that what present embodiment provided be applied to comprises upper plate 110, lower plate 120, cingulum 128 and OCT measuring probe 130.
Please refer to Fig. 2, upper plate 110 and lower plate 120 offer the mutually corresponding through hole in position, and upper plate 110 and lower plate 120 can closely be fixed together in conjunction with alignment pin 140 and screw 150 by these through holes.In the present embodiment, upper plate 110 and lower plate 120 also can directly use one piece of thin plate to replace, and the middle part of this thin plate offers rectangle windows district, and the material of thin plate adopts near-infrared absorption material to make simultaneously.
Upper plate 110 also offers through hole 112.Lower plate 120 also offers the rectangle be communicated with through hole 112 and to window district 122.And the aperture area of through hole 112 is greater than rectangle and windows the aperture area in district 122.In the present embodiment, rectangle district of windowing is of a size of long 0.5mm ~ 30mm, wide 0.5mm ~ 30mm.
Please refer to Fig. 3, double faced adhesive tape 124 is also posted in the bottom of lower plate 120, and the double faced adhesive tape in present embodiment is medical dual-side glue.It is noted herein that, this medical dual-side glue also needs a rectangular aperture in the rectangle of lower plate 120 position, district 122 of windowing, to ensure OCT measuring probe can not be subject to double faced adhesive tape and blocks impact when scanning skin area to be measured.The edge of lower plate 120 is provided with two cingulum installing holes 126, and by cingulum installing hole 126, lower plate can connect cingulum 128.In the present embodiment, cingulum 128 is adjustable in length cingulum.In addition, the window surrounding in district 122 of rectangle is ramp structure, and like this, OCT measuring probe is when scanning skin area to be measured, and the scanning ray light shone around inclined-plane can not be reflected back in OCT system, alleviates the interference because reflected light causes to a certain extent; Meanwhile, the window surrounding in district 122 of rectangle is coated with near infrared light strongly absorbing medium, reduces near infrared light further and turns back to probability OCT system from this region.
Below, we are described the skin area extracting method being applied to blood sugar test in conjunction with the above-mentioned skin area positioner being applied to blood sugar test.
Please refer to Fig. 4, the skin area extracting method of blood sugar test that what present embodiment provided be applied to, comprises the steps:
Step S110, determine skin area to be measured with being provided with the window lower plate 120 in district 122 of rectangle.After selected object to be measured, the lower plate 120 being applied to the skin area positioner of blood sugar test is closely attached on the skin of object to be measured by medical dual-side glue, uses adjustable in length cingulum lower plate 120 to be bundled in further on the skin of object to be measured simultaneously.Like this, the partial skin of object to be measured is just out exposed at rectangle place of district 122 of windowing, and the district 122 of windowing of the rectangle namely in lower plate 120 determines skin area to be measured.This to adjustable in length cingulum without the need to applying too large power, otherwise pressure can be produced to skin and cause the structure of skin inside to change.Owing to mainly adopting medical dual-side glue and adjustable in length cingulum, the lower plate 120 of the skin area positioner being applied to blood sugar test is positioned on the skin of object to be measured here, so this localization method not malleable skin histology inner structural features, that is too large impact can not be caused on the accuracy of testing result.
Step S120, upper plate 110 to be connected with lower plate 120, to fix upper plate 110 and lower plate 120 simultaneously.First three alignment pins 140 are used to be determined the position of lower plate 120 and upper plate 110; Then, tighten the screws 150 realizes the compact siro spinning technology between upper plate 110 and lower plate 120.And OCT measuring probe 130 is connected on upper plate 110, therefore OCT measuring probe 130 just can scan skin to be measured and peripheral region thereof easily.
Step S130, gather and at least comprise rectangle and to window the three-dimensional OCT image of the human body skin below district.Please refer to Fig. 5, in the present embodiment, additionally provide a kind of skin area navigation system being applied to blood sugar test, the skin area navigation system being applied to blood sugar test comprises the skin area positioner, OCT system 200 and the computer 300 that are applied to blood sugar test.The OCT measuring probe 130 being applied to the skin area positioner of blood sugar test is connected to OCT system 200.OCT system 200 is connected to computer 300.OCT system 200 scans the three-dimensional OCT image of intensity collection of the reflected light that skin to be measured and peripheral region thereof obtain according to OCT measuring probe 130.Computer 300 is for this three-dimensional OCT image of analyzing and processing.When utilizing OCT measuring probe 130 to scan skin to be measured, OCT measuring probe 130 needs scan rectangle to window skin area under district 122 and peripheral region thereof, ensure that region that OCT measuring probe 130 scans must be larger than the rectangle region that district 122 covers of windowing, such OCT system 200 can collect comprise rectangle window place of district 122 have the OCT three-dimensional data of skin histology.Please refer to Fig. 6, OCT measuring probe 130 pairs of lower plates 120 scan, and final OCT system 200 can obtain and comprise window district 122 place's human skin tissue and rectangle of rectangle and to window the OCT three-dimensional data of edge of district 122 lower plate 120.These OCT three-dimensional datas will be passed to computer 300 and carry out analyzing and processing.
Step S140, the three-dimensional OCT image comprising human skin tissue to be processed, skin area to be measured is extracted automatically.Because the OCT three-dimensional data obtained in step S130 had both comprised the OCT three-dimensional data of area skin to be measured, also comprise rectangle to window the OCT three-dimensional data of edge of district 122 lower plate 120, therefore, we need the OCT three-dimensional data extracting area skin to be measured from OCT three-dimensional data.In addition, the OCT three-dimensional data obtained in step S130 is the data that initial acquisition arrives, and we need to utilize image processing techniques to be further processed it.Concrete steps are as follows:
Step S141, please refer to Fig. 7, the three-dimensional OCT image comprising human skin tissue is projected in the depth direction, calculate the meansigma methods comprising the three-dimensional OCT image light intensity of human skin tissue, obtain two-dimensional projection image.Because the window surrounding in district 122 of rectangle in lower plate 120 is the ramp structure being coated with strong light absorbing medium, make in the light penetration depth of this position shallow, signal is weak relative to skin area to be measured after depth direction is average.Namely area skin to be measured and the reflectance of lower plate 120 to light have obvious difference, and therefore, the OCT three-dimensional data of area skin to be measured and the OCT three-dimensional data of lower plate 120 also have obvious difference.Like this, after being projected in the depth direction by the three-dimensional OCT image comprising human skin tissue, we just obtain the strong two-dimensional projection image of a width color contrast.In the figure 7, namely the image that middle part is rectangular-shaped represents the OCT three-dimensional data projection result in the depth direction of area skin to be measured.
Step S142, please refer to Fig. 8, adopt median filtering algorithm to remove noise jamming in two-dimensional projection image.In the gatherer process of OCT data, if when reflection is very strong, appear in the situation that in this depth bounds, intensity is all very large, this can produce interference in two-dimensional projection image, so need to adopt the noise jamming in median filtering algorithm removal two-dimensional projection image.
Step S143, employing Da-Jin algorithm are split filtered two-dimensional projection image, obtain skin area and non-skin region.Please refer to Fig. 9, in order to the two-dimensional projection image of the two-dimensional projection image and non-skin region of more clearly distinguishing skin area, we adopt Da-Jin algorithm to split filtered two-dimensional projection image, obtain a width black white image.In fig .9, white portion image represents the two-dimensional projection image of skin area, and black region image represents the two-dimensional projection image in non-skin region.
Step S144, to segmentation after two-dimensional projection image carry out the process of morphology opening operation.Please refer to Figure 10, the step of morphology opening operation process can make the border between the two-dimensional projection image of skin area and the two-dimensional projection image in non-skin region more level and smooth, eliminates tiny spine, thus reduces these interference to the impact of skin area extraction.
After step S144, according to the XY coordinate of XY coordinate determination skin area in three-dimensional OCT image in skin area two-dimensional projection image after singulation, from three-dimensional OCT image, extract three-dimensional OCT skin image according to this XY coordinate.
Please refer to Figure 11, utilize after the above-mentioned skin area extracting method being applied to blood sugar test accurately locates skin area to be measured, we just accurately can gather the OCT data of skin area to be measured.
The above-mentioned skin area positioner being applied to blood sugar test, can ensure that skin area position to be measured is substantially fixing, realize the object of locating skin area to be measured.In addition, additionally provide a kind of skin area extracting method being applied to blood sugar test, first by lower plate 120 and detected skin area compact siro spinning technology, then upper plate 110 is connected to lower plate 120, thus ensures that skin area position to be measured is substantially fixing.Secondly the window three-dimensional OCT image of human body skin in district less than 122 of rectangle that comprises collected is processed, automatically extract skin area to be measured further, thus the precision and stability that blood sugar concentration is detected is higher.Also provided is a kind of skin area navigation system being applied to blood sugar test, after the skin area positioner being applied to blood sugar test is to skin area Primary Location to be measured, computer is utilized to adopt image processing techniques automatically to extract skin area to be measured.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. one kind is applied to the skin area positioner of blood sugar test, it is characterized in that, comprise OCT measuring probe, upper plate and be connected to the lower plate of described upper plate, described upper plate is connected to described OCT measuring probe, double faced adhesive tape and cingulum is connected with bottom described lower plate, and described lower plate offers rectangle windows district, described upper plate offers and is communicated with described rectangle and windows the through hole in district; Described lower plate is close to skin to be measured by double faced adhesive tape and cingulum, and described rectangle windows district for determining skin area to be measured, and described OCT measuring probe is for scanning skin to be measured and peripheral region thereof.
2. the skin area positioner being applied to blood sugar test according to claim 1, is characterized in that, described upper plate is connected with screw lock by alignment pin location with lower plate.
3. the regional positioning device being applied to blood sugar test according to claim 1, is characterized in that, described rectangle district of windowing is of a size of long 0.5mm ~ 30mm, wide 0.5mm ~ 30mm.
4. the skin area positioner being applied to blood sugar test according to claim 1, is characterized in that, the window surrounding in district of described rectangle is ramp structure.
5. the skin area positioner being applied to blood sugar test according to claim 4, is characterized in that, the window surrounding in district of described rectangle is coated with near-infrared absorption medium.
6. the skin area positioner being applied to blood sugar test according to claim 1, it is characterized in that, described upper plate and lower plate are respectively one piece of thin plate, and the middle part of described lower plate offers rectangle windows district, and described upper plate offers and is communicated with described rectangle and windows the through hole in district.
7. the skin area positioner being applied to blood sugar test according to claim 6, is characterized in that, the material of described thin plate is near-infrared absorption material.
8. one kind is applied to the skin area navigation system of blood sugar test, it is characterized in that, comprise the skin area positioner being applied to blood sugar test, OCT system and the computer according to any one of claim 1 to 6, the described OCT measuring probe being applied to the skin area positioner of blood sugar test is connected to described OCT system, and described OCT system is connected to described computer; Described OCT system scans the three-dimensional OCT image of intensity collection of the reflected light that skin to be measured and peripheral region thereof obtain according to described OCT measuring probe, and described computer is used for three-dimensional OCT image described in analyzing and processing.
9. use in claim 1 the skin area extracting method being applied to blood sugar test of the skin area positioner being applied to blood sugar test, it is characterized in that, comprise the steps:
(1) skin area to be measured is determined with being provided with the window lower plate in district of rectangle;
(2) upper plate is connected with lower plate, fixes upper plate and lower plate simultaneously;
(3) gather and at least comprise rectangle and to window the three-dimensional OCT image of the human body skin below district;
(4) the three-dimensional OCT image comprising human skin tissue is processed, skin area to be measured is extracted automatically.
10. the skin area extracting method being applied to blood sugar test according to claim 9, it is characterized in that, processing at the described three-dimensional OCT image to comprising human skin tissue, carrying out skin area to be measured, in the step automatically extracted, comprising the steps:
(1) the three-dimensional OCT image comprising human skin tissue is projected in the depth direction, calculate the meansigma methods comprising the three-dimensional OCT image light intensity of human skin tissue, obtain two-dimensional projection image;
(2) noise jamming in median filtering algorithm removal two-dimensional projection image is adopted;
(3) adopt Da-Jin algorithm to split filtered two-dimensional projection image, obtain skin area and non-skin region;
(4) process of morphology opening operation is carried out to the two-dimensional projection image after segmentation;
(5) according to the XY coordinate of skin area determination skin area in three-dimensional OCT image obtained in described step (3), and three-dimensional OCT skin image is extracted in three-dimensional OCT image.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310210400.0A CN103315749B (en) | 2013-05-30 | 2013-05-30 | Skin area positioning device, method and system applicable to blood glucose detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310210400.0A CN103315749B (en) | 2013-05-30 | 2013-05-30 | Skin area positioning device, method and system applicable to blood glucose detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103315749A CN103315749A (en) | 2013-09-25 |
| CN103315749B true CN103315749B (en) | 2015-01-14 |
Family
ID=49185003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310210400.0A Active CN103315749B (en) | 2013-05-30 | 2013-05-30 | Skin area positioning device, method and system applicable to blood glucose detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103315749B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI597690B (en) * | 2016-09-23 | 2017-09-01 | 財團法人國家實驗硏究院 | Detecting apparatus based on image for blood glucose concentration and method thereof |
| US10531818B2 (en) | 2016-01-18 | 2020-01-14 | Erasmus University Medical Center Rotterdam | Tissue sample analysis |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188664B (en) * | 2014-09-01 | 2016-03-30 | 苏州光环科技有限公司 | Blood sugar test scaling method and system |
| CN105832305B (en) * | 2016-06-20 | 2018-10-16 | 上海交通大学 | Wear-type optical coherence tomography system for free movement animal |
| CN106963392B (en) * | 2017-03-16 | 2020-02-07 | 河北大学 | Optical noninvasive blood glucose detection two-dimensional correlation calibration method and system |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579321A (en) * | 2004-05-21 | 2005-02-16 | 天津大学 | Airspace light-diving differential wavelength spectro meter for detecting artery blood content and detection method thereof |
| CN201026212Y (en) * | 2006-12-21 | 2008-02-27 | 浙江大学 | Non-destructive detection device for blood glucose based on optical coherence tomography fundus imaging |
| CN101346097A (en) * | 2005-12-22 | 2009-01-14 | 皇家飞利浦电子股份有限公司 | System for non-invasive measurement of blood glucose concentration |
| CN102349834A (en) * | 2011-06-20 | 2012-02-15 | 深圳职业技术学院 | Human body blood sugar concentration noninvasive detection method and system thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8036727B2 (en) * | 2004-08-11 | 2011-10-11 | Glt Acquisition Corp. | Methods for noninvasively measuring analyte levels in a subject |
| US8078244B2 (en) * | 2005-12-14 | 2011-12-13 | Newton Photonics, Inc. | Interferometric method and instrument for measurement and monitoring blood glucose through measurement of tissue refractive index |
| US20120150001A1 (en) * | 2010-11-04 | 2012-06-14 | Compact Imaging | Hyaluronic acid based glucose monitoring |
| JP5716589B2 (en) * | 2011-07-25 | 2015-05-13 | 富士通株式会社 | Biological component measuring apparatus and biological component measuring method |
-
2013
- 2013-05-30 CN CN201310210400.0A patent/CN103315749B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579321A (en) * | 2004-05-21 | 2005-02-16 | 天津大学 | Airspace light-diving differential wavelength spectro meter for detecting artery blood content and detection method thereof |
| CN101346097A (en) * | 2005-12-22 | 2009-01-14 | 皇家飞利浦电子股份有限公司 | System for non-invasive measurement of blood glucose concentration |
| CN201026212Y (en) * | 2006-12-21 | 2008-02-27 | 浙江大学 | Non-destructive detection device for blood glucose based on optical coherence tomography fundus imaging |
| CN102349834A (en) * | 2011-06-20 | 2012-02-15 | 深圳职业技术学院 | Human body blood sugar concentration noninvasive detection method and system thereof |
Non-Patent Citations (1)
| Title |
|---|
| JP特开2013-22338A 2013.02.04 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10531818B2 (en) | 2016-01-18 | 2020-01-14 | Erasmus University Medical Center Rotterdam | Tissue sample analysis |
| TWI597690B (en) * | 2016-09-23 | 2017-09-01 | 財團法人國家實驗硏究院 | Detecting apparatus based on image for blood glucose concentration and method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103315749A (en) | 2013-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Heibel et al. | A review of noninvasive techniques for skin cancer detection in dermatology | |
| CN103315749B (en) | Skin area positioning device, method and system applicable to blood glucose detection | |
| Hinz et al. | Assessment of tumor thickness in melanocytic skin lesions: comparison of optical coherence tomography, 20-MHz ultrasound and histopathology | |
| Huelsbusch et al. | Contactless mapping of rhythmical phenomena in tissue perfusion using PPGI | |
| Ardigo et al. | Concordance between in vivo reflectance confocal microscopy and histology in the evaluation of plaque psoriasis. | |
| Favazza et al. | In vivo photoacoustic microscopy of human cutaneous microvasculature and a nevus | |
| Sun et al. | In vivo estimation of water diffusivity in occluded human skin using terahertz reflection spectroscopy | |
| CN103720489B (en) | Pathological tissues growth monitoring method and system | |
| CN118986289A (en) | Sensor for tissue measurement | |
| Crisan et al. | Ultrasonographic assessment of skin structure according to age | |
| CN107788950B (en) | Blood flow imaging method and system based on self-adaptive threshold segmentation | |
| US20150342508A1 (en) | Non-invasive optical measurement of blood analyte | |
| CN204121004U (en) | A kind of pulse diagnostic information acquisition device in conjunction with multiple pressure-type sensor | |
| CN108309244A (en) | A kind of novel pressure sensor skin capilary scanning means and system and working method | |
| Sigsgaard et al. | In vivo measurements of blood vessels’ distribution in non‐melanoma skin cancer by dynamic optical coherence tomography—a new quantitative measure? | |
| JP5990906B2 (en) | Measuring device, measuring method, program, and recording medium | |
| CN104188664B (en) | Blood sugar test scaling method and system | |
| Xin et al. | Correlation analysis between advanced glycation end products detected noninvasively and skin aging factors | |
| Li et al. | Non‐invasive medical imaging technology for the diagnosis of burn depth | |
| CN103340635B (en) | Optical parameter and blood glucose concentration three-dimensional correlation calculation method based on OCT | |
| WO2025055788A1 (en) | Octa-based non-invasive continuous blood glucose measurement method and apparatus | |
| CN105466883A (en) | Device and method for detecting ischemic cerebrum based on TeraHertz wave reflecting type imaging | |
| Zugaj et al. | A novel image processing workflow for the in vivo quantification of skin microvasculature using dynamic optical coherence tomography | |
| CN104523284B (en) | Blood glucose measurement system based on holographic nanometer detection and minimally invasive tissue fluid extraction | |
| CN110575182A (en) | Method and device for detecting blood sugar |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211104 Address after: Room 33036, No. 3, Shuangqing Road, Haidian District, Beijing 100085 Patentee after: BEIJING CHINA LIGHT TECHNOLOGY CO.,LTD. Address before: 215021 unit 1-b202, creative industrial park, No. 328, Xinghu street, Suzhou Industrial Park, Jiangsu Province Patentee before: SUZHOU OPTORING TECHNOLOGY Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240725 Address after: Unit 1-B202, Creative Industry Park 328 Xinghu Street, Suzhou Industrial Park, Jiangsu Province Patentee after: SUZHOU OPTORING TECHNOLOGY Co.,Ltd. Country or region after: China Address before: Room 33036, No. 3, Shuangqing Road, Haidian District, Beijing 100085 Patentee before: BEIJING CHINA LIGHT TECHNOLOGY CO.,LTD. Country or region before: China |
|
| TR01 | Transfer of patent right |