CN103315360A - Radix cynanchi bungei granule and preparation method thereof - Google Patents
Radix cynanchi bungei granule and preparation method thereof Download PDFInfo
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- CN103315360A CN103315360A CN2013102526869A CN201310252686A CN103315360A CN 103315360 A CN103315360 A CN 103315360A CN 2013102526869 A CN2013102526869 A CN 2013102526869A CN 201310252686 A CN201310252686 A CN 201310252686A CN 103315360 A CN103315360 A CN 103315360A
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- radix cynanchi
- granule
- cynanchi bungei
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- concentrate
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a radix cynanchi bungei granule and a preparation method thereof. The preparation method comprises the steps of: crushing Chinese herbal medicines such as radix cynanchi bungei, adding water in the radix cynanchi bungei, reflux extracting, concentrating, membrane separating or normal pressure concentrating to obtain a concentrated solution, and performing alcohol precipitation on the concentrated solution or adding a flocculating agent in the concentrated solution to clarify or membrane separating or resin adsorbing the concentrated solution to remove ineffective ingredients; and concentrating, drying, crushing, adding a corrigent, an excipient or a combined additive thereof, and packaging to obtain the radix cynanchi bungei granule. The radix cynanchi bungei granule provided by the invention integrates the advantages of traditional Chinese medicine composition and carrier or filler, the process is optimized by experiments, the effective ingredients of the traditional Chinese medicine are completely extracted in a simple and easy manner, and the process is easy to control. The radix cynanchi bungei granule has the functions of nourishing liver and kiney and replenishing essence and blood, and the formed product is free of harmful residue, thereby being a safe and environment-friendly healthcare product.
Description
Technical field
The present invention relates to a kind of herbal mixture tea-drinking product and preparation method thereof, being specifically related to this traditional Chinese medicine of the five flavours medicinal material of radix cynanchi bungei, gynostemma pentaphylla, bluish dogbane, reticulate millettia and cogongrass rhizome or its medicine materical crude slice is that raw material prepares compound radix cynanchi bungei particle and preparation method thereof.
Background technology
Radix cynanchi bungei is the dried root of polygonaceae plant radix cynanchi bungei, and its nature and flavor are bitter, sweet, puckery, tepor, enter liver, kidney channel.RADIX POLYGONI MULTIFLORI PREPARATA filling liver kidney, benefiting essence-blood, strengthen the bone, but relieving leukorrhea by astringents also is tonic medicine, is used for liver kidney two void, the empty few soreness and weakness of waist and knees of essence and blood, dizzy, poliosis, seminal emission, uterine bleeding, is with inferior disease.A little less than the Radix Polygoni Multiflori qi-restoratives power, be longer than detoxifcation, preventing malaria, relax bowel, the diseases such as the treatment sore is swollen, scrofula, chronic malaria are more than, the dry constipation of intestines.Compendium of Material Medica carry the tuber of multiflower knotweed " the beneficial liver of nourishing blood, the controlling nocturnal emission with astringent drugs kidney-nourishing, muscle reinforcing and bone strengthening, black moustache is sent out, and is tonic medicine, cold not dry, merit is on glutinous rehmannia, all medicines of lucid asparagus." " Kaibao Bencao " claim its " only pained, beneficial vim and vigour, black moustache is sent out, and pleases color, the long muscles and bones of clothes of a specified duration, beneficial marrow is prolonged life not old ".Pharmacology analysis shows, radix cynanchi bungei contains anthraquinone analog compound, mainly contains Chrysophanol and archen, secondly is Rhein (product of processing do not contain Rhein), Physcion and rheum officinale anthrone, starch, crude fat, lecithin etc.
The radix cynanchi bungei integration of drinking and medicinal herbs, Radix Polygoni Multiflori has reducing blood lipid, the effect that relaxes bowel.Radix cynanchi bungei processed has filling liver kidney, and the effect of benefiting essence-blood can be used for a long time.Integration of drinking and medicinal herbs article, the article that can be used for health food and health food forbidding article are made concrete regulation.Radix cynanchi bungei is as medicine, and active ingredient sees that patent of invention declares content.Just radix cynanchi bungei being located the first-selected medication of cranial vascular disease as far back as the Ministry of Public Health in 2002, is not only pharmaceutically acceptable but also can be used for the article of health food.
Radix cynanchi bungei in modern medicine, have improve sleep, build up resistance, all multiactions such as black beard and hair, lowering blood pressure blood sugar.Radix cynanchi bungei by processing for biotechnology now, become can long-term taking new resource food, security is good, enters market fast, easily is accepted.
Chinese medicinal granule be over past ten years to the breakthrough of traditional Chinese medicine medicine materical crude slice application form, mainly be take the prepared slices of Chinese crude drugs as raw material, form through the operations such as modern crafts extraction, Vacuum Concentration, drying, granulation are refining, effect is basically identical with the maintenance of former medicine materical crude slice.The application of Chinese medicinal granule, the marrow that has kept Chinese Traditional Medicine---diagnosis and treatment based on an overall analysis of the illness and the patient's condition, with the characteristic of disease prescription, have again exempt to fry in shallow oil easy clothes, effect rapidly, composition fully, determined curative effect, safety and sanitation and the advantage such as easy to carry, be conducive to standardization and the internationalization of Chinese medicine.
Summary of the invention
The object of the present invention is to provide the Chinese herbal medicine effective ingredients such as a kind of radix cynanchi bungei to extract completely new Chinese medicine preparation and preparation method thereof, have filling liver kidney, the effect of benefiting essence-blood.
For achieving the above object, the present invention is by the following technical solutions:
A kind of compound radix cynanchi bungei granule, its raw material comprises the component of following parts by weight:
10～20 parts of 40～50 parts of radix cynanchi bungeis, 20～30 parts of gynostemma pentaphylla, 10～20 parts of bluish dogbanes, 10～20 parts of reticulate millettias and cogongrass rhizomes.
Described raw material through extracting, filters successively, and concentrated filtrate is removed the concentrate invalid components, and is again concentrated, and drying makes described granule after the series of steps such as adding auxiliary material granulation.
The invention also discloses a kind of method for preparing described granule, comprise the following steps:
(1) 2～20 times of normal temperature dippings or the heating that described raw material are added water to total amount extract at least twice, and the gained extract merges, and filters;
(2) filtrate decompression is concentrated or film concentrated or normal pressure is concentrated into and contains crude drug 0.1g/mL～2g/mL;
(3) concentrate is carried out alcohol precipitation or the clarification of adding flocculant or film and separate ultrafiltration, the preferred film aperture is between 1um～100nm, or resin adsorption is removed invalid element; ,
(4) and then concentrated, dry, add auxiliary material, granulate packing.
It can be to add ethanol to reach volume ratio 40%～80% to containing the alcohol amount in concentrate that alcohol precipitation in above-mentioned steps (3) is removed invalid element, leaves standstill or refrigerates, and removes insoluble matter and gets clarified solution.
It can be to remove sediment add shitosan (preferred weight concentration 0.5～1%) and fining agent (such as tannic acid or gelatin) flocculation in concentrate after that invalid element is removed in flocculation in above-mentioned steps (3), makes clear and bright liquid.
It can be that concentrate is passed through macroporous resin column that resin adsorption in above-mentioned steps (3) is removed invalid element, preferred aperture 300～1000nm, and active ingredient is adsorbed, and is 50～95% ethanol elution with volume ratio, collects eluent and gets final product.
Described raw material is medicinal material or medicine materical crude slice, and normal temperature dipping extraction time can be 3～24h, and heating extraction time is 0.5～5h, and temperature is 30～65 ℃ during extraction.
Auxiliary material in the above-mentioned steps (4) is flavouring, excipient or its combination.Be refined liquid by reduced pressure concentration or film is concentrated or normal pressure is concentrated into thick paste or the thousands of medicinal extract of the further drying under reduced pressure of thick paste or thick paste and is spray dried to dry powder in step (4) Chinese medicinal liquid concentrating, drying, can be made into the radix cynanchi bungei pulvis.
Described flavouring is sweetener, Aspartame, stevioside, acesulfame potassium and/or xylitol.
Described excipient is starch, polyvinylpyrrolidone, beta-schardinger dextrin-, dextrin, sodium carboxymethylcellulose and/or low-substituted hydroxypropyl cellulose.
Advantage of the present invention is: the various technology modes in radix cynanchi bungei pulvis and granule raw material composition and the preparation process thereof are preferred through many experiments research, have that the effective component of Chinese herbal medicine such as radix cynanchi bungei extracts fully, loss of effective components is little, simple, be easy to control, yield and quality is stable, without the characteristics of hazard residue.Finished product of the present invention is a kind of novel health product, and wide market prospects are arranged.
The specific embodiment
Embodiment 1:
Get radix cynanchi bungei, gynostemma pentaphylla, bluish dogbane, reticulate millettia, cogongrass rhizome medicinal material 500g, with its chopping, add the water refluxing extraction 2 times, add for the first time 8 times of water gagings, add 6 times of water gagings, each 1h of extraction time for the second time, again the gained extract is merged, filters, extract is evaporated to 500mL, and contain crude drug amount in the concentrate this moment is 1.0g/mL, then adds ethanol, make and contain alcohol amount in the concentrate and reach 60% (volume), leave standstill 24h, filter, filtrate decompression is concentrated again, be dried to thick paste, add again cane sugar powder, dry, pulverizing, packing namely gets the radix cynanchi bungei pulvis.
Embodiment 2:
Get radix cynanchi bungei, gynostemma pentaphylla, bluish dogbane, reticulate millettia, cogongrass rhizome medicine materical crude slice 1000g, boiling 3 times, decoct respectively 5h, 3h, 2h at every turn, the gained extract is merged, filters, normal pressure is concentrated into 2000mL again, contain crude drug amount in the concentrate this moment is 2.0g/mL, then add weight ratio and be 2.0% chitin solution, leaving standstill 12h filters, filtrate decompression more concentrated, drying under reduced pressure gets dry extract, add starch, sodium carboxymethylcellulose auxiliary material again, make granule by dry granulation, packing namely gets the radix cynanchi bungei granule.
Embodiment 3:
Get radix cynanchi bungei, gynostemma pentaphylla, bluish dogbane, reticulate millettia, cogongrass rhizome medicinal material 100kg, boiling 5 times, decoct respectively 2h at every turn, 2h, 1h, 1h, 1h, the gained extract is merged, filter, normal pressure is concentrated into 1000L again, contain crude drug amount in the concentrate this moment is 1.5g/mL, concentrate is by macroporous resin column (aperture 700nm), ethanol elution with 50～95% is collected eluent, and the eluent decompression is concentrated into thick paste again, the thousands of powder of spray-drying, add again dextrin, the low-substituted hydroxypropyl cellulose auxiliary material makes the granule that every gram particle is equivalent to the 12g raw medicinal herbs by dry granulation, and packing namely gets the radix cynanchi bungei granule at last.
Embodiment 4:
Get radix cynanchi bungei, gynostemma pentaphylla, bluish dogbane, reticulate millettia, cogongrass rhizome medicinal material 500g, boiling 3 times decocts respectively 2h, 2h, 1h at every turn, merge filter behind the extract or directly normal pressure be concentrated into 250mL, concentrate adds ethanol, makes to contain the alcohol amount and reach 80%; Refrigeration 24h filters, and filtrate decompression more concentrated, drying under reduced pressure gets dry extract, by dry, pulverizing, packing, namely gets the radix cynanchi bungei pulvis.
Embodiment 5:
Get radix cynanchi bungei, gynostemma pentaphylla, bluish dogbane, reticulate millettia, cogongrass rhizome medicinal material 500g, boiling 2 times, decoct respectively 1h at every turn, after merging extract, filter, adopt again ultrafiltration (membrane aperture 100nm) to be concentrated into 400mL, concentrate is by 200 molecular weight membrane separation plants, collect active ingredient, collect the liquid decompression and be concentrated into again thick paste, add polyvinylpyrrolidone, beta-schardinger dextrin-, lactose, sodium carboxymethylcellulose auxiliary material, make particle by wet granulation, drying, packing namely gets the radix cynanchi bungei granule.
Embodiment 6:
Get radix cynanchi bungei, gynostemma pentaphylla, bluish dogbane, reticulate millettia, cogongrass rhizome medicinal material 1500g, boiling 3 times, decoct respectively 2h, 2h, 1h at every turn, the gained extract is merged, filters, be evaporated to clearly cream, spraying drying powder-forming directly makes particle by dry granulation, and packing namely gets the radix cynanchi bungei granule.
Embodiment 7:
Get radix cynanchi bungei, gynostemma pentaphylla, bluish dogbane, reticulate millettia, cogongrass rhizome medicinal material 500g, boiling 2 times decocts respectively 1h at every turn, and the gained extract is merged, filters, adopt again film to be concentrated into 400mL, concentrate is used 60% ethanol elution by macroporous resin column (aperture 700nm), collects eluent, eluent reduced pressure concentration, drying under reduced pressure get dry extract, add starch, polyvinylpyrrolidone auxiliary material again, make particle by dry granulation, packing namely gets the radix cynanchi bungei granule.
Embodiment 8:
Get radix cynanchi bungei, gynostemma pentaphylla, bluish dogbane, reticulate millettia, cogongrass rhizome medicinal material 200kg, boiling 2 times decocts respectively 2h, 1h at every turn, and the gained extract is merged, filters, and is evaporated to 200L, cold heavy 24h.High speed centrifugation or plate compression, filtrate decompression more concentrated, drying under reduced pressure get dry extract, add cane sugar powder, beta-schardinger dextrin-, starch supplementary material again, make particle by dry granulation, and packing namely gets the radix cynanchi bungei granule.
Embodiment 9:
Get radix cynanchi bungei, gynostemma pentaphylla, bluish dogbane, reticulate millettia, cogongrass rhizome medicinal material 500g, add water retting 3 times, flood respectively 12h, 10h, 5h at every turn, the gained extract is merged, filters, again extract is evaporated to 250mL, concentrate adds ethanol, makes to contain the alcohol amount and reach 55%, refrigeration 24h, filter, filtrate decompression is concentrated, drying under reduced pressure gets dry extract, directly makes particle by dry granulation, and packing namely gets the radix cynanchi bungei granule.
The effect experiment:
Experiment condition and requirement:
The experiment crowd: 34～81 years old, 163 people, wherein, and without disease patient 84 people, cardiovascular patient 44, often constipation person 16 people suffer from other patient 19 people.
Take granule for making according to the method for implementing 1.
Drinking method: each 5 grams, day drink 10～20 grams, boiling water is taken after mixing it with water.
Experimental result:
After drinking 10 days, 69 people (accounting for 42.3%) sensation energy is than drink is front not vigorous; After drinking January, 155 people (accounting for 95.4%) sensation energy is than drink is front not vigorous, and wherein 56 people's effects are obvious especially, and 37 people feel that resistance has strengthened; Most of T-CHOL (TC), the higher patient of triglycerides (TG), its courage is admittedly liquor-saturated, triglyceride has reduction in various degree, hyperpietic's dizziness, headache sx↓, constipation person's symptom obviously alleviates.
Animal experiment
According to modern medicine study, radix cynanchi bungei contains Anthraquinones, hexichol ene compound and lecithin, can be combined with cholesterol, reduces enteron aisle to the heavily absorption of cholesterol, reduces blood fat, atherosclerosis.The compound radix cynanchi bungei granule hyperlipidemia rats blood fat and the Mesentery microcirculation that utilize embodiment 1 to make are studied.72 Wistar rats are divided into 12 of Normal groups at random, 60 of modeling groups.The modeling group gives high lipid food 28d, after the modeling success, is divided at random the high, medium and low dosage group of hyperlipidemia model group and compound radix cynanchi bungei granule, the positive drug control group.Give respectively physiological saline, the high, medium and low dosage of compound radix cynanchi bungei granule and Herb Gynostemmae Pentaphylli total glycosides tablet gavage 25d, the blood fat indices of animal used as test and the change of Mesentery microcirculation after the observation medication.Model group rat blood serum T-CHOL (TC), triglycerides (TG), LDL-C (LDL-C) all are significantly higher than normal group, and HDL-C significantly is lower than normal group; Mesentery microcirculation is observed and is found that treatment group external caliber, VPV obviously improve than the hyperlipemia group, and the open number of capillary obviously increases.The result shows: compound radix cynanchi bungei granule can obviously reduce the hyperlipidemia rats blood fat, improves its Mesentery microcirculation obstacle.
Claims (7)
1. compound radix cynanchi bungei granule, its raw material comprises the component of following parts by weight:
10～20 parts of 40～50 parts of radix cynanchi bungeis, 20～30 parts of gynostemma pentaphylla, 10～20 parts of bluish dogbanes, 10～20 parts of reticulate millettias and cogongrass rhizomes;
Described raw material through extracting, filters successively, and concentrated filtrate is removed the concentrate invalid components, and is again concentrated, drying, and the adding auxiliary material is granulated and is namely made described granule.
2. granule as claimed in claim 1, wherein said auxiliary material is to be flavouring and/or excipient.
3. a method for preparing claim 1 or 2 described granules comprises the following steps:
(1) described raw material is added water normal temperature dipping or heating extraction at least twice, the gained extract merges, and filters;
(2) filtrate decompression is concentrated or film concentrated or normal pressure is concentrated into and contains crude drug 0.1g/mL～2g/mL;
(3) concentrate is carried out alcohol precipitation or the clarification of adding flocculant or film separation or resin adsorption and remove invalid element;
(4) and then concentrated, dry, add auxiliary material, granulate packing.
4. method as claimed in claim 3, wherein to remove invalid element be that to add volumetric concentration in concentrate be 40%～80% ethanol to the alcohol precipitation in (3), leaves standstill, and removes insoluble matter and get clarified solution.
5. method as claimed in claim 3, wherein to remove invalid element be to remove sediment add the chitosan clarifier flocculation in concentrate after to the flocculation in (3), makes clear and bright liquid.
6. method as claimed in claim 3, wherein the resin adsorption in (3) remove invalid element be with concentrate by macroporous resin column, active ingredient is adsorbed, and is 50～95% ethanol elution with volumetric concentration, the collection eluent gets final product.
7. method as claimed in claim 3, wherein normal temperature dipping extraction time is 3～24h in (1), and heating extraction time is 0.5～5h, and temperature is 30～65 ℃ during extraction.
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