CN103301561A - High-flexibility radioactive particle and implanting method thereof - Google Patents
High-flexibility radioactive particle and implanting method thereof Download PDFInfo
- Publication number
- CN103301561A CN103301561A CN2012100707314A CN201210070731A CN103301561A CN 103301561 A CN103301561 A CN 103301561A CN 2012100707314 A CN2012100707314 A CN 2012100707314A CN 201210070731 A CN201210070731 A CN 201210070731A CN 103301561 A CN103301561 A CN 103301561A
- Authority
- CN
- China
- Prior art keywords
- elastic
- radioactive
- radioactive particle
- medical
- particle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a high-flexibility radioactive particle and an implanting method of the high-flexibility radioactive particle. The radioactive particle comprises an elastic shell 1 and a radiation source 2, wherein the elastic shell 1 can be deformed under the action of external force, and can be restored after the external force is removed; the radiation source 2 is a particle containing radioactive isotopes capable of treating tumors; and the elastic shell 1 is coated on the radiation source 2. The elastic shell 1 has high elasticity, and can adapt to a bent pipeline, so that the radioactive particle has high flexibility, can be released through a complex bent pipeline, and meets the requirement on the implantation of a tumor shape adapting radioactive particle can be met.
Description
Technical field
The present invention relates to a kind of radioactive particle, especially for the embedded type radioactive particle for the treatment of tumor.
Background technology
By implanting
125The I radioactive particle is treated tumor, has become one of a kind of effective ways for the treatment of of solid tumors at present.Prior art
125The typical structure of I radioactive particle is as follows: will
125I is adsorbed on the silver metal rod of diameter 0.5mm, length 3.5mm, has then adsorbed this
125It is that 0.8mm, length are in the titanium light-wall pipe of 4.5mm that the silver-colored rod of I is encapsulated in external diameter.Because prior art is this
125The I radioactive particle is the cylinder of rigidity, thereby can only put by staight needle type implantation device, needs repeatedly tumor section to be punctured, and could form effective increased radioactivity and covering.There is following shortcoming in this prior art:
1) a radion implant needle can only relate to a direction, a position.But in tumor therapeutic procedure, often need radion is distributed in multi-direction implantation a plurality of positions of tumor, so just needing to implement multichannel puncture particle implants, namely need a plurality of percutaneous puncture points and a plurality of puncture needle tubing and a plurality of puncture nook closing member, the apparatus that uses is more, cloth source and inconvenient operation, the damage that the patient is caused is large, and medical expense is high.
2) tumor, intracranial tumor behind the rib that stops if any skeleton for the tumor of privileged sites or behind the breastbone, and the tumor at the many position of peripheral vessels and intestinal tube such as pancreas tumor etc., the radion implant needle of prior art is difficult to reach desired location, thereby can't implement and operate.
3) can not select and change direction and the position of implantation, so be difficult to be fit to shape of tumor, can't realize that suitable shape is implanted.
For this reason, the inventor discloses a kind of single channel multidirectional tumor conformal shape radioactive particle implantation device in the patent application of CN 101829393A, by being arranged on the looper of head, can realize by single channel the implantation of multi-direction multiple location, reduce the use of apparatus, reduced patient's damage.But this new particle implanting device head is looper, i.e. arc pin, this rigid cylindrical build of prior art
125The I radioactive particle is can not be by the bending section of looper, thereby need to the radioactive particle of prior art be improved, and provides a kind of new
125The I radioactive particle.
Summary of the invention
The radioactive particle of the present invention's high-flexibility, described radioactive particle contain elastic shell 1 and radioactive source 2; Elastic shell 1 is the elastomer that can deform under external force and can recover to be out of shape behind the external force removal; Radioactive source 2 is to contain the radioisotopic granule that can treat tumor; Elastic shell 1 coats radioactive source 2.
Described elastic shell 1 is the thin-wall case that contains bellows structure, is comprised of sealing 10 and corrugated tube 11, and sealing 10 seals up two ends of corrugated tube 11, and forms rounding off between the corrugated tube 11.
Described corrugated tube 11 adopts medical elastic metal thin-wall corrugated tube, and the medical elastic metal is selected from: the medical materials such as Ti-Ni marmem, titanium zirconium niobium elastic alloy, titanium-based amorphous attitude elastic alloy, Zirconium based amorphous elastic alloy, medical elastic rustless steel.
The width L1 of the groove of described corrugated tube 11 is between 0.05mm～2mm, the width L2 on protruding rank is between 0.05mm～2mm, the height H on protruding rank is between 0.05mm～2mm, and the thickness δ of light-wall pipe is between 0.01mm～0.5mm, and the D outer diameter of light-wall pipe is between 0.5mm～2mm.
Described radioactive source 2 movable being placed in the corrugated tube 11, or through movable being placed in the corrugated tube 11 after elastic metallic yarn 23 connections.
Described elastic shell 1 contains the thin-wall case of helical spring structure, formed by sealing 10, helical spring 12 and the radiation-resistant medical flexible film 13 of energy, seal 10, seal up two ends of helical spring 12, and form rounding off between the helical spring 12, coated fully by elastic film 13.
Further, described helical spring 12 adopts the manufacturing of medical elastic tinsel, and the medical elastic metal is selected from: the medical materials such as Ti-Ni marmem, titanium zirconium niobium elastic alloy, titanium-based amorphous attitude elastic alloy, Zirconium based amorphous elastic alloy, medical elastic rustless steel.
Described radioactive source 2 movable being placed in the helical spring 12, or through the movable helical spring 12 that is placed on after elastic metallic yarn 23 connections.
Described elastic shell 1 is the elastomer 14 that the radiation-resistant medical elastic macromolecular material of the energy that can implant for a long time in human body is made; Can be selected from by radiation-resistant medical elastic macromolecular material: medical polyurethane, medical polyethylene, the elasticity macromolecular materials such as medical silica-gel.
Further, described radioactive source 2 is embedded in the elastomer 14 of the radiation-resistant medical elastic macromolecular material manufacturing of energy with a gap.
Described radioactive source 2 contains metallic particles 21 and radiosiotope 22; Radiosiotope 22 is adsorbed on the metallic particles 21.
Described radiosiotope 3 is selected from: I (iodine) 125, Pd (palladium) 103, Ir (iridium) 192, Cs (caesium) 131, Yb (ytterbium) 169; The most frequently used is
125I, i.e. I (iodine) 125.
The present invention also provides the method for implantation of the radioactive particle of high-flexibility, and described method for implantation is to be that the particle implantation device of arc looper discharges with the radioactive particle of the present invention's high-flexibility by head.
The invention discloses the radioactive particle of high-flexibility, contain elastic shell 1 and radioactive source 2; Elastic shell 1 is the elastomer that can deform under external force and can recover to be out of shape behind the external force removal; Radioactive source 2 is to contain the radioisotopic granule that can treat tumor; Elastic shell 1 coats radioactive source 2.Because elastic shell 1 has good elasticity, can adapt to crooked pipeline, so this radioactive particle has good compliance, can discharge by the crooked pipeline of complexity, satisfy the requirement that tumor conformal shape radioactive particle is implanted.
Description of drawings
Fig. 1 is the structural representation of the bellows radioactive particle that independently distributes of the present invention's radioactive source.
Fig. 2 is the structural representation of bellows radioactive particle of the present invention's radioactive source series arrangement.
Fig. 3 is the structural representation of bellows radioactive particle of the present invention's helical spring series arrangement.
Fig. 4 is the structural representation of the spiral spring type radioactive particle that independently distributes of the present invention's radioactive source.
Fig. 5 is the structural representation of the present invention's elastomeric-type radioactive particle.
Fig. 6 is that the present invention's radioactive particle is by the fundamental diagram of the curved bend tune of particle implantation device.
Among the above-mentioned figure: 1 is elastic shell, and 2 is radioactive source, and 4 are the present invention's radioactive particle, and 5 is the crooked interior pin of implantation device, and 6 is the outer pin of implantation device, and 7 is the inner core push rod of implantation device; 10 are sealing, and 11 is corrugated tube, and 12 is helical spring, 13 is elastic film, and 14 is elastomer, and 21 is metallic particles, 22 is radiosiotope, 23 is elastic yarn, and 231 is the helical spring structure on the elastic metallic yarn, and L1 is the width of the groove of corrugated tube, L2 is the width on the protruding rank of corrugated tube, H is the height on the protruding rank of corrugated tube, and δ is the thickness of light-wall pipe, and D is the external diameter of light-wall pipe.
The specific embodiment
Embodiment 1: the bellows radioactive particle that the present invention's radioactive source independently distributes
With reference to figure 1, in the present embodiment, the bellows radioactive particle that the present invention's radioactive source independently distributes is disclosed, described radioactive particle contains elastic shell 1 and radioactive source 2.
The width L1 of the groove of described corrugated tube 11 is between 0.05mm～2mm, the width L2 on protruding rank is between 0.05mm～2mm, the height H on protruding rank is between 0.05mm～2mm, and the thickness δ of light-wall pipe is between 0.01mm～0.5mm, and the D outer diameter of light-wall pipe is between 0.5mm～2mm.
Described radioactive source 2 contains metallic particles 21 and radiosiotope 22.Metallic particles 21 adopts sphere or the ellipsoidal particle of silver metal usually, or the sphere of titanium or titanium alloy or ellipsoidal particle, or other the non-magnetic metallic particles that can implant for a long time in human body.The diameter of metallic particles 21 is about 2 times of L2 usually greater than the width L2 on protruding rank, and guarantee fund's metal particles 21 can freely-movable between corrugated tube 11 inwalls.Radiosiotope 22 is selected
125I.Radiosiotope 22 is attached on the metallic particles 21, has formed radioactive source 2.
Because the elastic shell 1 that corrugated tube consists of can deform under external force and can recover distortion behind the external force removal, make things convenient for the present invention's radioactive particle by crooked arc section.Like this, the present invention's radioactive particle can pass through the crooked arc section of the complexity of particle implantation device, carries out particle and implants, with reference to figure 6.
Embodiment 2: the structural representation of the bellows radioactive particle of the present invention's radioactive source series arrangement.
With reference to figure 2, the present embodiment is substantially the same manner as Example 1, and its difference is: metallic particles 21 centers are provided with through hole, and elastic metallic yarn 23 passes the centre bore of metallic particles 21, metallic particles 21 riveted joint fixedly on the elastic metallic yarn 23 metallic particles 21 spaced apart.Elastic metallic yarn 23 adopts the manufacturing of medical elastic metal material, is the Ti-Ni marmem silk of 0.3mm as adopting diameter, and this structure manufacturing cost is lower, also can satisfy clinical requirement.
Can also be provided with helical spring structure 231 on the elastic metallic yarn 23.Helical spring structure 231 is located on the elastic metallic yarn 23 that connects between 2 metallic particles 21, with reference to figure 3.
Embodiment 3: the structural representation that is the spiral spring type radioactive particle that independently distributes of the present invention's radioactive source.
With reference to figure 4, the present embodiment is substantially the same manner as Example 1, and its difference is: described elastic shell 1 is the thin-wall case that contains helical spring structure.Elastic shell 1 is comprised of sealing 10, helical spring 12 and the radiation-resistant medical flexible film 13 of energy; Sealing 10 seals up two ends of helical spring 12, and forms rounding off between the helical spring 12, is coated fully by elastic film 13.
Described helical spring 12 is that the medical elastic tinsel is made close-packed helical elastic tube, and described medical elastic metal is selected from: the medical materials such as Ti-Ni marmem, titanium zirconium niobium elastic alloy, titanium-based amorphous attitude elastic alloy, Zirconium based amorphous elastic alloy, medical elastic rustless steel.
Described energy radiation-resistant medical flexible film 13 be selected from: medical polyurethane, medical polyethylene, the elasticity macromolecular materials such as medical silica-gel.Medical flexible film 13 coats helical spring 12 and sealing 10 fully.
Since this spiral spring type elastic shell 1 easy flexural deformation and recovery distortion, thereby have good compliance, and the present invention's radioactive particle can pass through the crooked arc section of the complexity of particle implantation device, carries out particle and implants, with reference to figure 6.
Embodiment 4: the structural representation that is the present invention's elastomeric-type radioactive particle.
With reference to figure 5, the present embodiment is substantially the same manner as Example 1, and its difference is: described elastic shell 1 is the elastomer 14 that the radiation-resistant medical elastic macromolecular material of the energy that can implant for a long time in human body is made.Can be selected from by radiation-resistant medical elastic macromolecular material: medical polyurethane, medical polyethylene, the elasticity macromolecular materials such as medical silica-gel.Described radioactive source 2 is embedded in the radiation-resistant medical elastic macromolecular material elastomer 14 of energy with a gap.
Because the elastic shell 1 easy flexural deformation that the radiation-resistant medical elastic macromolecular material of this energy elastomer 14 consists of and recovery distortion, thereby has a good compliance, the present invention's radioactive particle can pass through the crooked arc section of the complexity of particle implantation device, carry out particle and implant, with reference to figure 6.
Embodiment 5: the method for implantation of the present invention's radioactive particle
The present invention's radioactive particle is put into special particle implantation device, when particle passes through the crooked segmental arc of implantation device, the elastic shell 1 easy flexural deformation of particle and recovery distortion, thereby has a good compliance, the needle tubing 5 that adapts to the implantation device bending, the present invention's radioactive particle can be submissive pass through crooked segmental arc, discharge, with reference to figure 6.
Should be noted that open structure with illustrating can replace with the identical structure of other effect herein, the embodiment that simultaneously the present invention introduces realizes unique structure of the present invention.Although preferential embodiment of the present invention is introduced in this article and is illustrated; but those skilled in the art know and know that these embodiment illustrate; those skilled in the art can make countless variations, improvement and replacement; and can not break away from the present invention; therefore, should define protection scope of the present invention according to what the spirit and scope of appending claims of the present invention were come.
Claims (14)
1. the radioactive particle of high-flexibility, it is characterized in that: described radioactive particle contains elastic shell (1) and radioactive source (2); Elastic shell (1) is the elastomer that can deform under external force and can recover to be out of shape behind the external force removal; Radioactive source (2) is to contain the radioisotopic granule that can treat tumor; Elastic shell (1) coats radioactive source (2).
2. the radioactive particle of described high-flexibility according to claim 1, it is characterized in that: elastic shell (1) contains the thin-wall case of bellows structure, formed by sealing (10) and corrugated tube (11), sealing (10) seals up two ends of corrugated tube (11), and forms rounding off between the corrugated tube (11).
3. the radioactive particle of described high-flexibility according to claim 2, it is characterized in that: described corrugated tube (11) adopts medical elastic metal thin-wall corrugated tube, and the medical elastic metal is selected from: Ti-Ni marmem, titanium zirconium niobium elastic alloy, titanium-based amorphous attitude elastic alloy, Zirconium based amorphous elastic alloy, medical elastic rustless steel.
4. the radioactive particle of described high-flexibility according to claim 2, it is characterized in that: the width L1 of the groove of described corrugated tube (11) is between 0.05mm～2mm, the width L2 on protruding rank is between 0.05mm～2mm, the height H on protruding rank is between 0.05mm～2mm; the thickness δ of light-wall pipe is between 0.01mm～0.5mm, and the D outer diameter of light-wall pipe is between 0.5mm～2mm.
5. the radioactive particle of described high-flexibility according to claim 2, it is characterized in that: described radioactive source (2) is movable to be placed in the corrugated tube (11), or connects rear movable being placed in the corrugated tube (11) through elastic metallic yarn (23).
6. the radioactive particle of described high-flexibility according to claim 1, it is characterized in that: described elastic shell (1) contains the thin-wall case of helical spring structure, formed by sealing (10), helical spring (12) and the radiation-resistant medical flexible film of energy (13), sealing (10), seal up two ends of helical spring (12), and helical spring forms rounding off between (12), is coated fully by elastic film (13).
7. the radioactive particle of described high-flexibility according to claim 6, it is characterized in that: described helical spring (12) adopts the manufacturing of medical elastic tinsel, and the medical elastic metal is selected from: Ti-Ni marmem, titanium zirconium niobium elastic alloy, titanium-based amorphous attitude elastic alloy, Zirconium based amorphous elastic alloy, medical elastic rustless steel.
8. the radioactive particle of described high-flexibility according to claim 6, it is characterized in that: described radioactive source (2) is movable to be placed in the helical spring (12), or connects the rear movable helical spring (12) that is placed on through elastic metallic yarn (23).
9. the radioactive particle of described high-flexibility according to claim 1 is characterized in that: elastic shell (1) is the elastomer (14) that the radiation-resistant medical elastic macromolecular material of energy that can implant for a long time in human body is made.
10. the radioactive particle of described high-flexibility according to claim 9, it is characterized in that: described radiation-resistant medical elastic macromolecular material is selected from: medical polyurethane, medical polyethylene, medical silica-gel.
11. the radioactive particle of described high-flexibility according to claim 9, it is characterized in that: described radioactive source (2) is embedded in the radiation-resistant medical elastic macromolecular material of energy (14) with a gap, and radioactive source (2) is coated fully by medical elastic macromolecular material (14).
12. the radioactive particle of described high-flexibility according to claim 1, it is characterized in that: radioactive source (2) contains metallic particles (21) and radiosiotope (22); Radiosiotope (22) is adsorbed on the metallic particles (21).
13. the radioactive particle of described high-flexibility according to claim 1, it is characterized in that: described radiosiotope (3) is selected from: I (iodine) 125, Pd (palladium) 103, Ir (iridium) 192, Cs (caesium) 131, Yb (ytterbium) 169.
14. the method for implantation of the radioactive particle of high-flexibility is characterized in that: the radioactive particle of described high-flexibility is the particle implantation device release of arc looper by head.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100707314A CN103301561A (en) | 2012-03-16 | 2012-03-16 | High-flexibility radioactive particle and implanting method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100707314A CN103301561A (en) | 2012-03-16 | 2012-03-16 | High-flexibility radioactive particle and implanting method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103301561A true CN103301561A (en) | 2013-09-18 |
Family
ID=49127559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100707314A Pending CN103301561A (en) | 2012-03-16 | 2012-03-16 | High-flexibility radioactive particle and implanting method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103301561A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103736201A (en) * | 2013-12-31 | 2014-04-23 | 原子高科股份有限公司 | Radioactive particle chain |
| CN105727432A (en) * | 2016-04-19 | 2016-07-06 | 牛洪欣 | Recyclable conformal radioactive particle cabin |
| CN106823121A (en) * | 2017-01-24 | 2017-06-13 | 原子高科股份有限公司 | A kind of degradable radioactive particle chain with shape memory function |
| CN116549678A (en) * | 2023-05-04 | 2023-08-08 | 天津赛德医药研究院有限公司 | Radiotherapy sensitization radioactive particle and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1167446A (en) * | 1994-10-27 | 1997-12-10 | 诺沃斯特股份有限公司 | Method and apparatus for treating vascular system |
| CN1360511A (en) * | 1999-07-14 | 2002-07-24 | 诺沃斯特公司 | Radioactive source train |
| WO2003039654A2 (en) * | 2001-11-02 | 2003-05-15 | Terwilliger Richard A | Radiation seeds having projections and indentations |
| CN2576264Y (en) * | 2002-10-14 | 2003-10-01 | 上海亚医科技开发有限公司 | Bendy metal puncturing implantation device with built-in radioactive particles and scale |
| US20040116767A1 (en) * | 2002-09-10 | 2004-06-17 | Lebovic Gail S. | Brachytherapy apparatus and methods of using same |
| CN102335052A (en) * | 2011-07-15 | 2012-02-01 | 南京微创医学科技有限公司 | Anti-restenosis digestive tract stent |
| CN202724446U (en) * | 2012-03-16 | 2013-02-13 | 吴沛宏 | High flexibility radioactive particle |
-
2012
- 2012-03-16 CN CN2012100707314A patent/CN103301561A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1167446A (en) * | 1994-10-27 | 1997-12-10 | 诺沃斯特股份有限公司 | Method and apparatus for treating vascular system |
| CN1360511A (en) * | 1999-07-14 | 2002-07-24 | 诺沃斯特公司 | Radioactive source train |
| WO2003039654A2 (en) * | 2001-11-02 | 2003-05-15 | Terwilliger Richard A | Radiation seeds having projections and indentations |
| US20040116767A1 (en) * | 2002-09-10 | 2004-06-17 | Lebovic Gail S. | Brachytherapy apparatus and methods of using same |
| CN2576264Y (en) * | 2002-10-14 | 2003-10-01 | 上海亚医科技开发有限公司 | Bendy metal puncturing implantation device with built-in radioactive particles and scale |
| CN102335052A (en) * | 2011-07-15 | 2012-02-01 | 南京微创医学科技有限公司 | Anti-restenosis digestive tract stent |
| CN202724446U (en) * | 2012-03-16 | 2013-02-13 | 吴沛宏 | High flexibility radioactive particle |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103736201A (en) * | 2013-12-31 | 2014-04-23 | 原子高科股份有限公司 | Radioactive particle chain |
| CN103736201B (en) * | 2013-12-31 | 2016-01-20 | 原子高科股份有限公司 | A kind of radioactive particle chain |
| CN105727432A (en) * | 2016-04-19 | 2016-07-06 | 牛洪欣 | Recyclable conformal radioactive particle cabin |
| CN106823121A (en) * | 2017-01-24 | 2017-06-13 | 原子高科股份有限公司 | A kind of degradable radioactive particle chain with shape memory function |
| CN116549678A (en) * | 2023-05-04 | 2023-08-08 | 天津赛德医药研究院有限公司 | Radiotherapy sensitization radioactive particle and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103301561A (en) | High-flexibility radioactive particle and implanting method thereof | |
| CN202724446U (en) | High flexibility radioactive particle | |
| CN202538132U (en) | Snakelike intracavitary catheter | |
| US20220192778A1 (en) | Marking device and implantation system | |
| EP2887994B1 (en) | Device for improving brachytherapy | |
| CN106422024B (en) | Catheter and balloon catheter | |
| CN102335052A (en) | Anti-restenosis digestive tract stent | |
| KR20190064595A (en) | Flexible stent | |
| CN203220682U (en) | Active particles for tumor treatment | |
| CN103830836A (en) | Drainage catheter capable of carrying radioactive particles | |
| CN202892669U (en) | Elastic radioactive particle | |
| CN103357117A (en) | Elastic active particle and implant method thereof | |
| CN115530907A (en) | Intracranial aneurysm interventional embolization treatment device | |
| CN103301560A (en) | Radioactive particles for treating tumor and implantation method | |
| CN106176002B (en) | Self-expansion type bracket | |
| KR20170112977A (en) | Medical Device | |
| CN202776515U (en) | Saccule eurynter for curing vertebral compression fracture | |
| CN106974752A (en) | Spiral particle support | |
| CN114869389B (en) | Intra-tumor stent for intracranial aneurysm | |
| CN211409551U (en) | Esophagus support | |
| CN114028049B (en) | Intracranial support bracket | |
| CN103932821A (en) | Covered stent | |
| JP6155765B2 (en) | Gastrointestinal stent | |
| CN108498939B (en) | Radioactive particles that can self-fix | |
| JP6855679B2 (en) | Gastrointestinal stent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130918 |