CN103285504B - Visualization cavity dosing device - Google Patents

Abstract

The present invention is a new clinical medical instrument, which is a visualized cavity drug delivery device, including a local drug delivery nebulizer, a visual device and a transparent tube made of medical polymer materials. A local drug delivery channel and an observation cavity are arranged in the axial direction. The local drug delivery nebulizer is connected to a connecting piece arranged at the rear end of the tube body, and the medicine is sent to the local drug delivery channel through the connecting piece. An optical fiber, the optical fiber is led out to the outside of the tube through the observation cavity to form a lead-out end, and the lead-out end is connected to the signal input end of the visual device. The medical device disclosed by the invention is efficient in use and can accurately administer medicine to cavity lesion sites.

Description

Visual cavity drug delivery device

technical field

The invention relates to a clinical medical device, in particular to a high-efficiency and accurate visualized drug delivery device in a local cavity.

Background technique

Lung infections are treated with antibiotics given by mouth or into a vein. Drugs circulate through the blood to the lesion site to achieve therapeutic purposes. Although intravenous administration can achieve effective antimicrobial drug concentrations in the lung parenchyma, drug penetration into the lumen and intraductal secretions is limited. In particular, multidrug-resistant bacteria are not sensitive to commonly used antibiotics, and conventional doses of intravenous medication are difficult to achieve therapeutically effective drug concentrations in the infection focus, resulting in poor therapeutic effects. Although sensitive antibiotics such as aminoglycosides, polymyxins, and vancomycin can play a certain antibacterial effect, their therapeutic window is narrow, which can easily lead to nephrotoxicity and neurotoxicity. application. Local aerosol inhalation of antibacterial drugs has little effect on the drug concentration in the blood, which can not only reduce the dose of systemic medication, but also avoid the toxic and side effects of drugs, so inhalation therapy is encouraged as an adjuvant therapy for systemic therapy. The airway provides a direct route of administration, and the high-efficiency nebulizer enables the targeted delivery of antibacterial drugs directly to the lungs through the airway. This method of administration can make the concentration of antibacterial drugs in sputum and lung tissue higher than that of intravenous administration Several times of that, and far higher than the minimum inhibitory concentration for the treatment of pneumonia caused by common bacteria.

Sufficient drug concentration and sufficient drug maintenance time are the keys to the successful treatment of pneumonia, but there is no evidence to prove that the drug aerosol provided by the nebulization device currently on the market can effectively reach the small airways of the lungs, nor can it be determined whether the nebulization will make enough Drugs are continuously deposited in the lung infection focus, and aerosol inhalation is easily affected by the patient's respiratory cooperation and patient compliance, and it cannot ensure that sufficient effective drugs reach the lesion, which limits the widespread use of aerosol inhalation of antibacterial drugs. Therefore, there is an urgent need for an aerosol inhalation device that can ensure that the inhalation of antibacterial drugs can more effectively allow sufficient antibacterial drugs to reach the small airways of the lungs and lung infection lesions. Equal cavity for local administration, better serve clinical work.

Contents of the invention

In order to overcome the above-mentioned deficiencies in the prior art, the present invention provides an efficient and accurate drug delivery device with local vision in the cavity.

The present invention adopts the following technical scheme to achieve the above object: a visualized cavity drug delivery device includes a local drug delivery nebulizer, a visual device, and a transparent tube made of medical polymer materials. The drug channel and the observation cavity, the local drug nebulizer is connected to the connecting piece arranged at the rear end of the tube body, and the drug is sent to the local drug delivery channel through the connecting piece, an optical fiber is arranged in the observation cavity, and the optical fiber passes through the observation cavity Lead out to the outside of the tube to form a lead-out end, which is connected to the signal input end of the visual device. The end of the observation cavity at the front end of the tube body is transparent and closed, and a sieve-shaped hole is arranged at the end of the local drug delivery channel. the

The device of the present invention has the advantages of adopting the above-mentioned structure: due to the visibility, it avoids the blindness in the atomization inhalation process, enables the front end of the atomization inhalation pipeline to reach the small airways of the lungs and accurately monitor the lungs. Inflammation localization, increasing the concentration and maintenance time of antibacterial drug administration in the local area of inflammation, can also reach the intestinal tract and genitourinary tract for local administration, realizing antibacterial treatment with high efficiency and low toxicity and side effects, and the operation is simple and has no technical requirements. The addition of a turning traction wire facilitates the control of tubes entering the small pulmonary airway, intestinal tract, urogenital tract, etc., and facilitates the drug delivery device to observe the tube walls of the small pulmonary airway, intestinal tract, and urogenital tract more clearly. .

Description of drawings

The device of the invention can be further illustrated by the non-limiting examples given in the accompanying drawings.

Fig. 1 is a structural representation of the present invention;

Fig. 2 is a schematic structural diagram of the present invention connected with a visual device and an atomizer;

Fig. 3 is the structural schematic diagram that the pipe body of the present invention can see from the front end to the rear end;

In the figure: 1-tube body; 2-optical fiber; 3-through hole; 4-connector; 5-local drug nebulizer; 6-visual device; 7-local drug channel; 8-observation chamber; - sieve hole; 10 - traction steel wire; 11 - outer fixing ring of steel wire; 12 - steel wire pulling handle.

Detailed ways

The apparatus of the present invention will be further described below in conjunction with the accompanying drawings and embodiments.

As shown in Fig. 1 and Fig. 2, the visualized intracavity drug delivery device includes a local drug delivery atomizer 5, a visual device 6 and a transparent tube 1 made of medical polymer material, and the tube body 1 is axially arranged There is a local drug delivery channel 7 and an observation cavity 8. The local drug delivery nebulizer 5 is connected to the connecting piece 4 arranged at the rear end of the tube body 1, and the medicine is sent to the local drug delivery channel 7 through the connecting piece 4. An optical fiber 2 is arranged in the cavity 8, and the optical fiber 2 is led out of the tube body 1 through the observation cavity 8 to form a lead-out end, and the lead-out end is connected to the signal input end of the visual device 6 . As shown in FIG. 3 , the end of the observation cavity 8 at the front end of the tube body 1 is transparently closed, and a sieve-shaped hole 9 is provided at the end of the local drug delivery channel 7 .

The front end of the pipe body 1 is a straight end, that is, the front end is an arc-shaped head. The side wall of the local drug delivery channel 7 is provided with through holes 3 or sieve holes.

Close to the inner wall or outer wall of the pipe body 1, a traction steel wire 10 is provided to facilitate the turning of the front end of the pipe body 1. The pulling wire 10 can be on the inner wall of the tube of the local administration channel 7 or the inner wall of the tube of the observation cavity 8 , preferably the inner wall of the tube of the observation cavity 8 . One end of the traction steel wire 10 is connected with the outer fixing ring 11 of the steel wire, and the other end is connected with the steel wire pulling handle 12 arranged at the rear end of the pipe body 1 . A groove is arranged on the outer wall of the front end of the pipe body 1, and the steel wire outer fixing ring 11 is fixed in the groove, so that the fixing ring 11 and the pipe body 1 are on the same plane. During operation, pushing and pulling the steel wire to pull the handle 12 can make the front end of the pipe body 1 turn.

The visualization device adopts the ultra-miniature optical fiber imaging system in the "visualized sputum suction catheter" system (application number is 200720188729.1, 201010297841.5). For example, Shanghai Precision Fiber Bronchoscope XZ3.

Working principle of the present invention: Insert the front end of the local drug delivery tube 1 into the airway from the mouth, nostril or tracheal intubation, connect the tail end of the local drug delivery channel with the nebulizer 5; under the guidance of the visual device 6 Deepen the front end of the local drug delivery channel into the peripheral airway of the lungs infiltrated by inflammation or find the focus of lung infection, and then turn on the nebulizer for local drug delivery of antibiotics. The same can be used for intestinal and genitourinary tracts. Insert the front end of the local drug delivery tube 1 into the intestinal tract from the anus or the urethra from the urethral opening, connect the tail end of the local drug delivery channel with the nebulizer 5; The front end is inserted into the lesion, and then the nebulizer is turned on for local administration of antibacterial drugs.

Claims (5)

1. visual cavity/canal drug administration device, comprise topical nebulizer (5), visual device (6) and the transparent tube body (1) adopting medical macromolecular materials to make, axially topical passage (7) and observation chamber (8) is provided with in body (1), it is characterized in that: the connector (4) being arranged on body (1) rear end the connection of described topical nebulizer (5), by connector (4), medicine is delivered to topical passage (7), optical fiber (2) is provided with in described observation chamber (8), optical fiber (2) leads to body (1) by observation chamber (8) and forms exit outward, exit connects the signal input part of visual device (6), observation chamber (8) termination of described body (1) front end is transparent confinement, the termination of topical passage (7) is provided with cribriporal (9), inwall or the outer wall of being close to described body (1) are provided with the traction steel wire (10) be convenient to body (1) front end and turned, described traction steel wire (10) one end is connected with steel wire extenal fixation ring (11), the other end and the steel wire being arranged on body (1) rear end pull handle (12) to be connected, handle is pulled to be turned in body front end.

2. visual cavity/canal drug administration device according to claim 1, is characterized in that: the front end of described body (1) is a head.

3. visual cavity/canal drug administration device according to claim 2, is characterized in that: described topical passage (7) sidewall is provided with through hole (3) or cribriporal.

4. visual cavity/canal drug administration device according to claim 1,2 or 3, is characterized in that: on the outer wall of body (1) front end, be provided with groove.

5. visual cavity/canal drug administration device according to claim 4, is characterized in that: described steel wire extenal fixation ring (11) is fixed in described groove.