CN103271998A - Application of ficus microcarpa L.f to preparation of products with radiation resisting effect - Google Patents
Application of ficus microcarpa L.f to preparation of products with radiation resisting effect Download PDFInfo
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- CN103271998A CN103271998A CN2013102014396A CN201310201439A CN103271998A CN 103271998 A CN103271998 A CN 103271998A CN 2013102014396 A CN2013102014396 A CN 2013102014396A CN 201310201439 A CN201310201439 A CN 201310201439A CN 103271998 A CN103271998 A CN 103271998A
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Abstract
The invention discloses a new application of a traditional Chinese medicine ficus microcarpa L.f to preparation of health care products or medicines with radiation resisting effect. Ficus microcarpa L.f is a common traditional Chinese medicine and can be prepared into the health care products or medicines for patients working in the radiation environments to take for a long time or for the patients to take before and after tumor radiotherapy.
Description
Technical field
The Chinese crude drug raw material that the present invention relates to is Folium fici microcarpae, is its purposes in preparation radiation protection health products or medicine specifically.
Technical background
Radiation is a kind of nature phenomenon, derives from each side such as environment, life; Especially popularizing and development of current social electronic product, various generation electron radiation products are used day by day extensive, and various electrical equipment such as mobile phone, computer, TV, refrigerator are called people's live and work necessary; The application of some nuclear energy waits each link all will cause the harm of human body, various radioactivity factors constantly increase, various radiation have been penetrated into the social life every field, such as in medical industry, the X-ray that radiodiagnosis and treatment are used, CT machine etc. makes doctors and patients' time of contact and probability increase, the radiotherapy malignant tumor is to utilize the X ray of the different-energy that all kinds of accelerators produce, electron ray, neutron ray, tumor cell is killed in the ionizing radiation such as gamma-radiation that proton ray and radioactive source discharge, but also normal tissue cell there is certain damaging action, as radiation pneumonia, neuritis etc.How reducing with radioprotective infringement is one of human health subject matter, and health product or the medicine of seeking to embody radiation resistance also are to study one of focus now.
Chinese invention patent publication number CN1660389A discloses a kind of radiation-resistant oral preparation of Chinese traditional medicinal and preparation method, is Ganoderma and rhodiola root composition, reaches radiation protection from the angle that improves immunity of organism.Chinese invention patent publication number CN101095515A discloses a kind of health food to the radiation hazradial bundle protective effect, is made up of Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Radix Rhodiolae, Radix Ophiopogonis, is suitable for contacting the radiation crowd.Chinese invention patent grant number CN1282455C authorizes the antiradiation drug of a kind of ginkgetin and tea polyphenols combination, being all to contain identical benzene ring structure and polyhydric phenols hydroxyl structure from two raw materials, is two kinds of proportioning raw materials combination backs to be embodied improve radiation-resistant effect.Since compositions or other products of plant origin, non-evident effect, and taking convenience can be taken for a long time as the more crowd of contact radiation, is well received.
Folium fici microcarpae (Ficus microcarpa L.f) is the leaf of moraceae plants Ficus microcarpa Linn. f, and is lightly seasoned, cool in nature, has heat clearing away and delivers; Removing toxic substances and promoting subsidence of swelling; The damp-clearing pain-relieving effect is used for giving birth to slowly illness such as tracheitis, tonsillitis, enteritis.Yet there are no bibliographical information but whether Folium fici microcarpae has radiation protection.
Summary of the invention
The object of the invention provides Folium fici microcarpae or its extract is used in preparation radiation protection health products or medicine.
Adopt Folium fici microcarpae or its extract as raw material, can be prepared into the health product or the medicine that are fit to peroral dosage form.
The present invention is the Folium fici microcarpae that screening obtains having clear and definite radiation resistance from Chinese crude drug, by improving radiation to the leucocytes reduction of body damage and removing interior free yl, reaches the effect of Antiradiation injury; Be applicable to radiation environment long-term work crowd and take, also be suitable for tumor radiotherapy front and back patient and take for a long time.
The specific embodiment
Experimental example 1 Folium fici microcarpae is tested the systematic influence of radiation damage mouse blood
1. Folium fici microcarpae water extract is to the influence of radiation damage mice peripheral white blood cell
1.1 experiment and medication
60 of cleaning level Male Kunming strain mice are divided into 5 groups at random: blank group, model group, the high, medium and low dosage group of blowing rattan, 12 every group.Except the blank group, all the other group mices are all used
60The Co ray carries out a subtotal body irradiation, and the irradiation total absorbed dose is 2.0Gy.
Each dosage group mice of Folium fici microcarpae in
60The previous day is irritated the Folium fici microcarpae aqueous extract that stomach gives corresponding dosage in the Co radiation, and matched group and model group animal are irritated the normal saline of stomach equivalent, and each organizes administration and normal saline is irritated stomach once every day, continuous seven days.Each treated animal respectively at radiation before, adopted mice tip blood twice after the radiation on the 7th day, measure the leukocyte count of peripheral blood.
1.2 experimental result
60Co roentgenization laboratory animal is after 7 days, and leukocyte count obviously reduces, and model group and blank group relatively have significant differences (P＜0.01), shows this experiment Radiata modeling success.
After each treated animal experiment administration, three dosage groups of Folium fici microcarpae water extract to the mice radiation after 7 days numeration of leukocyte have in various degree and improve, relatively have significant differences (P＜0.01) with model group, and between each dosage group obvious dose-effect relationship arranged.Above-mentioned experimental result shows, Folium fici microcarpae water extract has and improves the effect that the radiation damage damage causes the laboratory animal peripheral blood leucocyte to reduce; Folium fici microcarpae water extract the results are shown in following table 1 to the influence of radiation damage mice peripheral white blood cell.
Table 1 Folium fici microcarpae water extract influences radiation damage mice peripheral white blood cell
* model group compares P＜0.01 with blank group; * and model group be P＜0.01 relatively
2. molten leaves water extract is to radiation damage mouse bone marrow cells nucleated cell number and bone marrow cell micronucleus rate influence
2.1 experiment and medication
60 of cleaning level Male Kunming strain mice are divided into 5 groups at random: blank group, model group, the high, medium and low dosage group of blowing rattan, 12 every group.Except the blank group, all the other group mices are all used
60The Co ray carries out a subtotal body irradiation, and the irradiation total absorbed dose is 2.0Gy.
Each dosage group mice of Folium fici microcarpae in
60The previous day is irritated the Folium fici microcarpae aqueous extract that stomach gives corresponding dosage in the Co radiation, and matched group and model group animal are irritated dosage normal saline such as stomach, once a day, and continuous irrigation stomach seven days; The last stomach of irritating was put to death mice after 24 hours, separated femur, used Hank ' s liquid to go out whole medullary cells in the femur, counted under the mirror, calculated nucleated cell number in every milliliter of medullary cell; Take out breastbone, extrude bone marrow fluid and calf serum mixing, routine smear, methanol is fixed, Giemsa dyeing, distilled water flushing dries, micronucleus cell number in 1000 polychromatic erythrocytes of microscopically every animal of counting.
2.2 experimental result
Each organized the mice radiation after seven days, and the bone marrow nucleated cell number of model group mice and bone marrow cell micronucleus rate and blank group more all have significant difference (P＜0.01); Three dosage groups of Folium fici microcarpae mouse bone marrow cells nucleated cell number has increase in various degree, and each dosage group and model group relatively have significant difference (P＜0.01).Folium fici microcarpae three dosage group mouse Bone marrow cells micronucleus rates have reduction in various degree, and wherein high dose group and model group relatively have significant difference (P＜0.01).
Bone marrow nucleated cell number and cell micronucleus rate reflection radiation is to the index of body injury, and Folium fici microcarpae water extract can increase raying mouse bone marrow cells nucleated cell number, reduces bone marrow cell micronucleus rate, illustrates that molten leaves has to improve the bone marrow injury effect that radiation causes.The results are shown in following table 2.
Table 2 Folium fici microcarpae water extract is to radiation damage mouse bone marrow cells nucleated cell number and influence of cell micronucleus rate after seven days
* model group compares P＜0.01 with blank group; * and model group be P＜0.01 relatively
3 Folium fici microcarpae water extracts are to radiation damage mice blood and the active influence of liver organization superoxide dismutase (SOD)
3.1 experiment and medication
60 of Male Kunming strain mice of cleaning level are divided into 5 groups at random: blank group, model group, the high, medium and low dosage group of Folium fici microcarpae, 12 every group.Except the blank group, all the other group mices are all used
60The Co ray carries out a subtotal body irradiation, and the irradiation total absorbed dose is 2.0Gy.
Each dosage group mice of Folium fici microcarpae in
60The previous day is irritated the Folium fici microcarpae aqueous extract that stomach gives corresponding dosage in the Co radiation, and matched group and model group animal are irritated dosage normal saline such as stomach.Irritate stomach every day once, continuous seven days.The 7th day each treated animal extractd eyeball and got blood after the radiation, surveys the serum activity of SOD value; Get liver 1g 0.9%NaCl solution on the rocks 5ml and prepare 20% (w/v) liver tissue homogenate, the method that provides in the hydroxylamine assay testing cassete is provided is measured SOD energy value in the hepatic tissue.
3.2 experimental result
Radiation is all significantly decline of model group mice serum regulating liver-QI tissue SOD vigor after seven days, relatively has significant differences (P＜0.01) with the blank group.Each dosage group mice serum regulating liver-QI tissue SOD's vigor of the present invention and model group relatively have rising in various degree, wherein the SOD in serum value increases obviously in high, middle dosage group, with model group significant differences (P＜0.01) is arranged relatively, hepatic tissue SOD value increases obviously in high, middle dosage group, with model group significant differences (P＜0.01) is arranged relatively.
SOD is a kind of interior and closely-related protein of cellular oxidation metabolism of organism that extensively is present in, the SOD vigor is to reflect radiation to the sensitive indicator of body injury, and above-mentioned experimental result shows that the Folium fici microcarpae water extract is that the free radical vigor reaches the Antiradiation injury effect in the body by influencing.The Folium fici microcarpae water extract sees Table 3 to radiation damage mice serum and liver organization superoxide dismutase (SOD) activity influence.
Table 3 Folium fici microcarpae water extract is to radiation damage mice serum and liver organization superoxide dismutase (SOD) activity influence
* model group compares P＜0.01 with blank group; * and model group be P＜0.05 relatively.
Claims (2)
1. Folium fici microcarpae or its water extract purposes in preparation radiation-proof healthcare product or medicine.
2. purposes according to claim 1, it is characterized in that: described health product or medicine are oral formulations.
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| CN2013102014396A CN103271998A (en) | 2013-05-27 | 2013-05-27 | Application of ficus microcarpa L.f to preparation of products with radiation resisting effect |
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| CN2013102014396A CN103271998A (en) | 2013-05-27 | 2013-05-27 | Application of ficus microcarpa L.f to preparation of products with radiation resisting effect |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523769A (en) * | 2015-01-16 | 2015-04-22 | 钟朝庆 | Composition for firming hair for cancer and tumor patients receiving chemotherapy and using method thereof |
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| CN1423955A (en) * | 2001-12-09 | 2003-06-18 | 苏少宁 | Banyan tea and preparation thereof |
| CN101152255A (en) * | 2007-09-29 | 2008-04-02 | 广东药学院 | A kind of preparation method of ficus microphylla water extract extract |
| US20130052289A1 (en) * | 2011-08-22 | 2013-02-28 | Shou-Hsun Chiang | Medicine containing extracts of Ficus microcarpa for healing wounds of a diabetic patient |
| CN103006782A (en) * | 2013-01-14 | 2013-04-03 | 海南师范大学 | Ficus auriculata extract and application thereof in preparation of medicine used for treating osteoporosis |
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2013
- 2013-05-27 CN CN2013102014396A patent/CN103271998A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1423955A (en) * | 2001-12-09 | 2003-06-18 | 苏少宁 | Banyan tea and preparation thereof |
| CN101152255A (en) * | 2007-09-29 | 2008-04-02 | 广东药学院 | A kind of preparation method of ficus microphylla water extract extract |
| US20130052289A1 (en) * | 2011-08-22 | 2013-02-28 | Shou-Hsun Chiang | Medicine containing extracts of Ficus microcarpa for healing wounds of a diabetic patient |
| CN103006782A (en) * | 2013-01-14 | 2013-04-03 | 海南师范大学 | Ficus auriculata extract and application thereof in preparation of medicine used for treating osteoporosis |
Non-Patent Citations (1)
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| 刘力恒等: "小叶榕化学成分及药理活性的研究进展", 《时珍国医国药》 * |
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| CN104523769A (en) * | 2015-01-16 | 2015-04-22 | 钟朝庆 | Composition for firming hair for cancer and tumor patients receiving chemotherapy and using method thereof |
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Application publication date: 20130904 |