CN103271950A - Application of haematococcus pluvialis microcapsule powder - Google Patents
Application of haematococcus pluvialis microcapsule powder Download PDFInfo
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- CN103271950A CN103271950A CN2013101798692A CN201310179869A CN103271950A CN 103271950 A CN103271950 A CN 103271950A CN 2013101798692 A CN2013101798692 A CN 2013101798692A CN 201310179869 A CN201310179869 A CN 201310179869A CN 103271950 A CN103271950 A CN 103271950A
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Abstract
The invention provides an application of haematococcus pluvialis microcapsule powder in preparing a medicine or healthcare product for treating or preventing aging. By adopting the haematococcus pluvialis microcapsule powder, the anti-aging effect can be obviously improved, and particularly an outstanding improvement effect is realized on female skin.
Description
Technical field
The invention belongs to medical technology and field of food industry, be specifically related to a kind of application of Haematocoocus Pluvialls microcapsule powder.
Background technology
The average life that World Health Organization (WHO) announces: San Marino male and Japanese women rank the first with the average life of 80 years old and 86 years old respectively.The data show that State Statistics Bureau provides: the average life expectancy of world population in 2010 is 69.6 years old, the 6th national census: China male average life expectancy in 2010 is that 72.38 years old, women are 77.37 years old;
China's defying age industry development general overview: 1. market-ripe: the defying age concept entered China 15 years: marketing education work is finished substantially, and is now ripe; 2. the competitor is few: the product and the service that get involved market now are few, and resistance is few; 3. demand is big: defying age market is waken up, and demand is big especially; 4. develop limited: defying age related service industry is but developed limited.
China's defying age industry development market structure, economic development, rhythm of life are fast, skin is crossed presenility, the enthusiasm of anti-aging product grows to even greater heights, the anti-aging product consumption consciousness strengthens: the transformation of Chinese consumption idea: consumer from passive reply to active protection; Defying age has been the slogan of health proposition of a 21 century greatness.
The world market estimates to reach 82% to the Asian-Pacific area " defying age " industry rate of increase in 2015, is the hat in the whole world; The market value of whole world anti-aging product: the five-year, annual rate of growth is 8～10%; Rose to 1,760 hundred million dollars in 2015; It is predicted, the year two thousand thirty the whole world will have 1,000,000,000 populations and surpass 65 years old, following defying age market is through further increasing;
The foreign market: 2011 are only American market: the Amti-sanility health-care food sales volume adds up to above 2,000,000,000 dollars; Anti-aging beauty-care cosmetics and Amti-sanility health-care food have become two big pillar products of current international cosmetics industry and health food industry
Domestic market: anti-aging product in 2008: the Chinese market sales volume reaches 12,200,000,000 yuans; According to the Forbes data statistics: Chinese defying age market still has 1,000 hundred million yuan development space.
30 years old～60 years old female population of China: surpassed 3.2 hundred million by 2000, expecting the year two thousand thirty will be above 400,000,000; (urban woman near half)
There are nearly 2 one-tenth women to have the long term purchase health product to be used for defying age, beauty treatment; The anti-aging product consumption consciousness strengthens, and enthusiasm grows to even greater heights, and more trends towards operational maintenance;
" Chinese beauty culture market survey report " women at present is concerned about most the most popular service: defying age maintenance, speckle dispelling, the overall referral rate of whitening are respectively 72.2%, 52.6%, 50.0%.
Old and feeble: a kind of physiological phenomenon that each organ dysfunction of human body begins to reduce is a slow progressive process, is a kind of inevitable law of nature.Biology: spontaneous necessary process: structure degeneration, hypofunction, adaptability and resistance go down.Pathology: strain, infection, immune depression, nutritional disorder, dysbolismus; Physiology: begin until old ontogeny history from germ cell; Sociology: fangle is lost interest, detach oneself from reality, like missing old times or old friends.
Old and feeble performance skin:
Skin aging wrinkle, xerosis cutis, shortage gloss, skin occur and follows the string, and mottle appears in local skin (face);
Main relevant with dehydration, lipid oxidation, cell senescence and sunlight.
Beard and hair is greyish white, alopecia, bald;
◎ blepharoptosis, cornea periphery white Di occurs and are with;
The ◎ loss of tooth; Visual deterioration is tending towards hypermetropia; Audition is also easily degenerated;
The ◎ hormonal readiness descends;
◎ is aspect behavior: bradykinesia, stride are slowly, facial dull, hypomnesis, attention do not concentrate, and repetition often liked in language.
Old and feeble mechanism (theory), representative causes of senescence, free radical theory SOD enzyme is the main enzyme of removing free radical in the human body, a large amount of experimental datas show, SOD level of activity and life-span and immune system are in close relations. and the SOD activity of different animals has nothing in common with each other, minimum as mouse SOD activity, its life-span has only several years, and mouse be easy to get cancer and other disease. the SOD activity of primate is higher, therefore the life-span can reach 50-60 year. and people's SOD activity is higher, so the life-span should be longer, but with advancing age, the activity of SOD descends day by day in the human body, and the active oxygen and the free radical that get off constantly accumulated in last unable removing. and along with the bulk deposition of free radical, the aging speed of human body is constantly aggravation just.
Traditional Chinese medical science vital essence loss theory " element is asked golden deficient the truth opinion ": husband essence person, root of body is also; " Ling Shu Miraculous Pivot or Divine Axis Benshen ": so the substances of producing primal life activities being essence; " Ling Shu Miraculous Pivot or Divine Axis normal person exhausted ancient ": thus refreshing person, essence-QI from water and grain also, " Further Discourses on the Properties of Things " essence and blood all consumes.
The immunological theory of immunological theory aging can be divided into two kinds of viewpoints: the first, and the aging of immunologic function is the reason that causes body aging; The second, theory of autoimmunity is thought the autoimmune relevant with autoantibody decisive role in causing old and feeble process.The characteristics that individual level follows old and feeble immunologic function to change are the immunne response reductions to exogenous antigen, and the autoantigen immunne response is strengthened.Become big after the birth of the thymus of organ, tissue water normal person class with advancing age gradually, 13-14 year the time reaches the peak, begins atrophy afterwards, and functional deterioration obviously dwindled later in 25 years old.Cell, molecular level geriatric animals and people's T cell function descends, and quantity also reduces.
Haematocoocus Pluvialls (natural astaxanthin), Haematocoocus Pluvialls: being the monoplast green alga of fresh water, is Chlorophyta, volvocales, haematococcus; Haematocoocus Pluvialls has special biological property, is present in occurring in nature with the two kinds of forms of attitude and sporangiocyst attitude of moving about in the biocycle:
Haematocoocus Pluvialls runs into high illumination, high temperature, nutritive salt hunger, salt stress and oxidative pressure and can induce: the accumulation of a large amount of astaxanthins in the cell; It is the best biogenetic derivation of natural astaxanthin; Haematocoocus Pluvialls is the highest biology of occurring in nature natural astaxanthin content; Astaxanthin: the natural carotenoid containing oxygen derivative that is a kind of redness; Belong to the fat lysochrome; It extensively is present in occurring in nature, is main carotenoid in the marine animal body.
For human body, the place that astaxanthin is different with other carotenoid is that it can cross over blood brain barrier, and can not be converted into Vitamin A, and excessive Vitamin A is can be harmful.
Current, Haematocoocus Pluvialls is acknowledged as the best biology that occurring in nature is produced natural astaxanthin; The natural biological that Haematocoocus Pluvialls is known nature antioxidation, ageing resistance is the strongest; Begin by world's food, beauty treatment, medicine, health care circle extensively cognitive in recent years.
Astaxanthin is chain interruption type antioxidant: pass through the human body cell outer wall, directly oxygen-derived free radicals in the scavenger cell has extremely strong removing free radical antioxidation;
Astaxanthin reaches surface oxidation-resistant in film: prevent the intracellular matter oxidation; The protection cell health strengthens cell regeneration power, keeps the function of human body balance and reduces the senile cell accumulation, protects cell and DNA health from inside to outside, slow down aging.
Mitochondrial oxidative damage has accelerated the aging of cell, and this also is old and feeble reason; Remove excessive free radical and guarantee the mitochondrion normal function
Astaxanthin has protective wire plastochondria and antidotal characteristic;
Astaxanthin can prevent the peroxidating of phospholipid and other lipid, slow down aging
The astaxanthin antioxygenic property is 550 times of vitamin e, 10 times of beta-carotene, is described as " super antioxidant " and " super vitamin E ";
The anti-oxidation function of mensuration carotenoid such as Terao: astaxanthin can delay peroxide effectively and form;
Lee etc. studies show that: the effect of astaxanthin quenching activity oxygen in carotenoid act as the strongest;
The oxidation resistance of astaxanthin is powerful, strengthens the cell regeneration ability, reduces the accumulation of senile cell, slow down aging.
The immunologic function of astaxanthin energy appreciable impact animal when having antigen to exist, can significantly promote splenocyte to produce the ability of antibody, strengthens the generation of human body blood cell immunity globulin under the T cytositimulation:
Astaxanthin has enhancing immunity: can play endogenic repair, keep health the aging that immune depression causes.
Astaxanthin has special role to changeing the glutamine enzyme: can be subjected to the light time to consume putrescine (butanediamine) at skin, and oral astaxanthin is stronger than oral vitamin A to the inhibitory action of putrescine accumulation;
Therefore, the strong anti-oxidation of astaxanthin may make it become potential bright protective agent, effectively removes the free radical that causes skin aging, is used for stoping skin photoage, preventing skin aging.
Astaxanthin is the strongest antioxidant, and astaxanthin also can promote the metabolism of skin when reducing the skin microgroove, and the moisture of keyed skin, and making skin similarly is ball after the inflation; The skin water that becomes is tender;
Lac regis apis (lyophilized powder) Lac regis apis claims Lac regis apis or Lac regis apis again: the milky or the faint yellow emulsion liquid that are 5～15 age in days worker bee head nutrition glandular secretions; Royal jelly special odor with delicate fragrance; Lac regis apis lyophilized powder: be to adopt freeze-drying with the water sublimed in the Lac regis apis, make dry powder after the royal jelly that dries out is pulverized; Be the lifelong and drone larva only food in earlier stage of queen bee, be similar to mammiferous milk; Produce the raw material of Lac regis apis: Mel and fermented pollen; Lac regis apis: rare famous and precious, produce peculiarly, be the health food that pure natural food medicine has both;
Lac regis apis is with a long history as the human nutrition health product: the description of Lac regis apis effect is arranged as Bible, Koran and Gemarik; Just there is application in China at Qing Dynasty's initial stage: the slurry of proclaiming oneself king at that time is to specialize in the tribute that the emperor eats for " honey point ".
The composition of Lac regis apis is extremely complicated: the protein that is rich in, fatty acid, saccharide, peptide class active substance, organic acid, aminoacid, vitamin, hormone, mineral etc.; Fresh royal jelly: water accounts 62.5%～70.0%, dry 30.0%～37.5%.
Maximum with Protein content in the fresh royal jelly (dry weight), be about 36.0～55.0%, wherein 2/3 is albumin, the 1/3rd, the globulin royal jelly antibacterial peptide is a kind of antibacterial protein in the Lac regis apis; SOD is typical case's representative of antioxidant activity albumen, content 0.403ug/g.
The antioxidant activity of Lac regis apis: to removing free radical, suppress lipid peroxidation, alleviating DNA oxidative damage etc. remarkable result is arranged.Lac regis apis has immunoregulatory biologic activity again: the endogenous repair is played in the damage that immune depression causes.Many-sided combined effect: make Lac regis apis in control body peroxidization, the effect of slow down aging aspect is remarkable
Cu/Zn-SOD in the Lac regis apis, disproportionation makes the concentration of activity in vivo oxygen (ROS) keep dynamic equilibrium, keeps cell and normally breeds, and safeguards body protection system function, plays function in delaying senility, Lac regis apis albumen and hydrolyzate peptide class.
The strong anti-oxidation activity suppresses lipid peroxidation and free-radical generating and promotes human glutathione peroxidase (GPX) to form; SOD in the Lac regis apis, protein and hydrolyzate, trace element etc. have strong anti-oxidation, can synergism, remove superoxide anion, hydroxy radical isoreactivity oxygen, suppress lipid peroxide and form, alleviate the DNA oxidative damage, delay the aging that causes because of oxidative damage.Wang Nan etc. are by the experimentation of rat oral gavage to the frozen dry roral jelly slow down aging: Lac regis apis has obvious antioxidation, may be the mechanism of frozen dry roral jelly slow down aging;
Lac regis apis has immunoregulation effect, can play endogenic repair to the aging that immune depression causes: protein is the major function factor of Lac regis apis, MRJP1 wherein can induce the macrophage release tumor necrosis factor, and immune system is regulated and control, and the activity of its hydrolyzate is stronger; Fatty acid in the Lac regis apis: 10-HDA and 3,10-DDA are immunoregulatory material bases, and Glycerin, maintenance skin gloss are with fine and smooth.In elegant outer must the supporting earlier.Lac regis apis contains royal jelly protein, vitamin, mineral, steroid hormone class and peculiar 10-hydroxyl-2-decylenic acid thereof: can increase skin-nourishing, promote the epidermis cell vigor, prevent collagen, elastic fiber degeneration, keep skin gloss and fine and smooth, Glycerin, the facial pigmentation that goes down, the delaying decrepitude of skin effect:
China always just has slurry royal jelly for cosmetology, Glycerin.According to ancient Egypt's historical records: gram Lou Bake is pulled in and is considered to beautiful unsurpassed at that time, so she can keep the gorgeous secret formula of appearance just to be to use Lac regis apis.Alexander's record and Marco Polo's travel notes: all relevant for the description of Lac regis apis beauty therapeutic effect
Radix Ginseng: be the dry root and rhizome of Araliaceae herbaceous plant Radix Ginseng; Radix Ginseng is traditional famous and precious traditional tonic medicine: have effects such as qi-supplementing, blood-engendering, strengthening vital QI to eliminate pathogenic factors; Ancient times Radix Ginseng refined being called: Rhizoma Polygonati, Herba Stellariae Saxatilis, SHENCAO; Radix Ginseng among the people is called: first of " king of BAICAO ", the Northeast China three essentials-essence; Oriental medicine circle is described as: the superfine product of " YIN nourishing is mended and given birth to strengthening the body resistance "; First of tonic;
From traditional Chinese medicine theory, Radix Ginseng is traditional traditional tonic medicine: strongly invigorating primordial QI, but can supporing yang tonifying YIN again enrich blood, strengthening vital QI to eliminate pathogenic factors; Strengthen the medicine of healthy, strong and tonification: temperature compensation, nourishing, the anxious good merchantable brand of mending, delaying benefit are particularly useful for the old people; " Sheng Nong's herbal classic ": Radix Ginseng clothes of a specified duration can be made light of one's life by commiting suicide slow down aging; From modern medicine, Radix Ginseng has direct removing free radical or suppresses the generation of free radical: opposing prevents cell ageing to tissue and cells injury; Significantly improve the activity of SOD, reduce lipid peroxide (LPO) and MDA amount: delaying senility course; The function of the own antioxidant system of enhancing body: transfer the body endogenous cause of ill; Active component ginsenoside in the Radix Ginseng has superoxide dismutase in the blood of increasing (SOD) vigor, reduces the effect of lipid peroxidation deposits yields; Increase SOD content and activity in the skin, recover the cell normal physiological function; The fibroblastic activity of chafe promotes collagen protein synthesis, makes skin be tending towards rejuvenation, thus the delaying decrepitude of skin process; Promote cell metabolism, accelerate the synthetic of old and feeble Skin Cell nucleic acid and protein; Ultraviolet radiation is caused the protective effect that skin keratin forms cell injury, the effect for the treatment of and prevention skin photoage.
In above-mentioned prior art, do not find the very excellent product of a kind of senile-resistant efficacy.
Summary of the invention
The present invention is in order to solve above-mentioned problems of the prior art, provides a kind of Haematocoocus Pluvialls microcapsule powder in the preparation treatment or prevented application in antidotal medicine or the health product.Adopt the Haematocoocus Pluvialls microcapsule powder can significantly improve antidotal effect, especially female skin and possess the outstanding effect of improving.
Medicine of the present invention or health product also comprise: Radix Ginseng, Lac regis apis lyophilized powder.
In the present invention, the content of described Radix Ginseng is than being the 0.05-0.5 weight portion, and described content ratio with the Haematocoocus Pluvialls chemical compound is the 0.01-0.5 weight portion, and the content of described Lac regis apis lyophilized powder is than being the 0.05-0.5 weight portion.Preferably, the content of described Radix Ginseng is than being the 0.1-0.4 weight portion, and described content ratio with the Haematocoocus Pluvialls chemical compound is the 0.05-0.4 weight portion, and the content of described Lac regis apis lyophilized powder is than being the 0.1-0.4 weight portion.More electedly, described Radix Ginseng, the weight ratio of Haematocoocus Pluvialls chemical compound and Lac regis apis lyophilized powder is 3: 5: 4.
In the present invention, described Haematocoocus Pluvialls chemical compound is Haematocoocus Pluvialls powder and/or Haematocoocus Pluvialls oils and fats and derivant thereof.
In the present invention, described Haematocoocus Pluvialls powder is the Haematocoocus Pluvialls microcapsule powder.Employing microcapsule technology preparation, the human feeding trial by effect embodiment of the present invention shows that this method is compared with the compositions that adopts conventional art and prepared has better functional effect, especially is embodied in the aspect of improving of female skin.
In the present invention, described Haematocoocus Pluvialls microcapsule powder comprises Haematocoocus Pluvialls powder and beta-schardinger dextrin-.
In the present invention, the particle diameter of described Haematocoocus Pluvialls powder is the 10-20 order, and the particle diameter of described Haematocoocus Pluvialls microcapsule powder is the 100-200 order.
In the present invention, the weight ratio of described Haematocoocus Pluvialls powder and beta-schardinger dextrin-is 1: 4.
In the present invention, described Haematocoocus Pluvialls microcapsule powder is by molecular inclusion, spray drying method, and squeezing and pressing method or spraying are congealed the method preparation and are got.Adopt the Haematocoocus Pluvialls powder by microcapsule technology (molecular inclusion), keep biological active substances to the effect of living of human body, the bioavailability of enhanced activity material.Also can reduce the time of contact of active substance and external environment, improve the storage of product and the stability of processing, prolong the storage life of product.Alternatively, also can select for use other technologies to prepare Haematocoocus Pluvialls microcapsule powder of the present invention.
Above-mentioned health product also can further comprise filler, with as the seasoning effect, improve the mouthfeel that the people takes, and preferably, this filler includes but not limited to blue berry, xylitol.This filler and Haematocoocus Pluvialls, Lac regis apis lyophilized powder, the mass ratio of Radix Ginseng can be 8: 1: 4: 3.Tablet with 1g is example, comprises Haematocoocus Pluvialls 0.25g, Lac regis apis lyophilized powder 0.2g, Radix Ginseng 0.15g, filler 0.4g.And the mode of taking can be every 1g, every day 2 times, each 2.Wherein, active component Haematocoocus Pluvialls chemical compound 0.2g every day is advisable, and Radix Ginseng 0.6g every day is advisable.
Technique effect of the present invention is:
1, adopts the health product of ternary composition of the present invention can possess anti-aging effects very effectively, thereby can significantly improve skin aging, as improve skin coarseness, wrinkle of skin, skin elasticity, moisture of skin etc.
2, the advantage behind the Haematocoocus Pluvialls powder employing micro encapsulation: (1) has covered bad smell and taste (for example medicines such as cod-liver oil, sulfonamides and some Chinese herbal medicine) originally.(2) improve stability of drug.Can make medicine stable as easy oxidation, easily performance, medicine easily affected by environment by micro encapsulation.(3), prevent medicine at the gastric inactivation or reduce zest to stomach.For example urokinase, erythromycin, insulin etc. are easily at the gastric inactivation, and anti-inflammatory analgesic stimulates stomach, easily causes and can overcome these shortcomings behind the micro encapsulation by gastric ulcer.(4) make the liquid drug solidification be convenient to store.(5) be conducive to the compound medicine compatibility.For example can aspirin and the chlorphenamine embedding respectively of compatibility will be difficult to.(6) dissolution rate and the bioavailability of raising pharmaceutical preparation.Insoluble drug behind micro encapsulation such as paclitaxel, genistein, can increase the dissolubility of medicine in water and the dissolution rate of preparation, and then improve bioavailability of medicament and curative effect.(7) make medicine have slow release or controlled release properties, improve curative effect.As: be the vitamin D2 microcapsule that the wall material is made with chitosan and ethyl cellulose, not only in intestinal juice, have significant slow release effect.And greatly reduce vitamin D2 release under one's belt, reach the purpose of enteric.
Description of drawings
Fig. 1 becomes the preparation method flow chart of burst and placebo for each single;
Fig. 2 is the preparation method flow chart of the present composition 1;
Fig. 3 is the preparation method flow chart of the present composition 2;
Fig. 4, Fig. 5 become burst and Comparative Examples about the design sketch of skin overall condition for the present composition with single;
Fig. 6, Fig. 7 are that the present composition and Comparative Examples are about the design sketch of skin overall condition;
Fig. 8 is that the present composition and Comparative Examples are about the design sketch of xerosis cutis degree;
Fig. 9 is that the present composition and Comparative Examples are about the design sketch of wrinkle of skin.
The specific embodiment
Raw materials used all commercially available the getting of the present invention.Further set forth advantage of the present invention below by the specific embodiment.
Preparation embodiment
1) prescription:
Comparative Examples (placebo): starch 0.4g;
Compositions 1: Radix Ginseng 0.15g; Haematocoocus Pluvialls powder 0.05g; Lac regis apis lyophilized powder 0.2g;
Compositions 2: Radix Ginseng 0.15g; Haematocoocus Pluvialls microcapsule powder 0.25g; Lac regis apis lyophilized powder 0.2g.
2) preparation method:
Placebo: the preparation tablets technology that adopts Fig. 1: with starch 0.4g, add other adjuvant, mix, granulate, drying, granulate adds proper amount of lubricating agent, is pressed into the starch sheet.
The queen bee lodicule:
Adopt the preparation tablets technology of Fig. 1: with Lac regis apis 0.4g, add other adjuvant, mix, granulate, drying, granulate adds proper amount of lubricating agent, and compacting is in flakes.
The Radix Ginseng slice:
Adopt the preparation tablets technology of Fig. 1: with Radix Ginseng 0.4g, add other adjuvant, mix, granulate, drying, granulate adds proper amount of lubricating agent, and compacting is in flakes.
The Haematocoocus Pluvialls sheet:
Adopt the preparation tablets technology of Fig. 1: with Haematocoocus Pluvialls powder 0.4g, add other adjuvant, mix, granulate, drying, granulate adds proper amount of lubricating agent, and compacting is in flakes.
Compositions 1:
Adopt the preparation tablets technology of Fig. 2: with Radix Ginseng 0.15g, Haematocoocus Pluvialls powder 0.05g, Lac regis apis lyophilized powder 0.2g (prescription of compositions 1) mixes, granulates, drying, granulate adds proper amount of lubricating agent, and compacting is in flakes.
Compositions 2:
Adopt the preparation tablets technology of Fig. 3, the prescription of compositions 2 is made tablet.
Wherein, the particle diameter of the 0.25g Haematocoocus Pluvialls microcapsule powder in the compositions 2 is 150 orders, is 15 purpose Haematocoocus Pluvialls powder 0.05g by particle diameter, forms behind landfill by 0.20g wall material.Specifically can be by following any method preparation, concrete steps are:
Method one: molecular inclusion: technological process is: 1 part Haematocoocus Pluvialls powder, the beta-schardinger dextrin-that adds 4 parts, water is stayed in the steaming that adds 4 parts, with colloid mill homogenizing 20 minutes, the mixture that obtains left standstill 30 minutes, filtered, drying under reduced pressure 2 hours, pulverize, cross 100 mesh sieves, namely get the Haematocoocus Pluvialls microcapsule powder; The Haematocoocus Pluvialls microcapsule powder of gained mixes by above equal portions, tabletting, namely.
Method two: spray drying method: technological process is: 1 part Haematocoocus Pluvialls powder, add 4 parts wall material (selectable wall material), and mix, homogenizing, the emulsion that obtains, spray drying namely gets the Haematocoocus Pluvialls microcapsule powder; The Haematocoocus Pluvialls microcapsule powder of gained mixes by above equal portions, tabletting, namely.
Method three: squeezing and pressing method: technological process is: get 4 parts wall material (including but not limited to sodium alginate, gelatin, methylcellulose), with its fusing, the Haematocoocus Pluvialls powder that adds 1 part mixes, and obtains emulsion, add isobutanol, extruding, fragmentation is shared, drying namely gets the Haematocoocus Pluvialls microcapsule powder; The Haematocoocus Pluvialls microcapsule powder of gained mixes by above equal portions, tabletting, namely.
Method four: the method for congealing of spraying: technological process is: get 4 parts wall material, make it fusing, add 1 part Haematocoocus Pluvialls powder, the mixture that obtains adopts cryospray, namely gets the Haematocoocus Pluvialls microcapsule powder.
Compositions 3: Radix Ginseng 0.05g; Haematocoocus Pluvialls microcapsule powder 0.01g; Lac regis apis lyophilized powder 0.05g
Adopt the preparation tablets technology of Fig. 3, the prescription of compositions 3 is made tablet.
Wherein, the particle diameter of the 0.01g Haematocoocus Pluvialls microcapsule powder in the compositions 2 is 100 orders, is 10 purpose Haematocoocus Pluvialls powder 0.01g by particle diameter, forms behind landfill by 0.04g wall material.Specifically by above any method preparation.
Compositions 4: Radix Ginseng 0.1g; Haematocoocus Pluvialls microcapsule powder 0.05g; Lac regis apis lyophilized powder 0.1g
Adopt the preparation tablets technology of Fig. 3, the prescription of compositions 4 is made tablet.
Wherein, the particle diameter of the 0.05g Haematocoocus Pluvialls microcapsule powder in the compositions 4 is 120 orders, is 12 purpose Haematocoocus Pluvialls powder 0.05g by particle diameter, forms behind landfill by 0.2g wall material.Specifically by above any method preparation.
Compositions 5: Radix Ginseng 0.4g; Haematocoocus Pluvialls microcapsule powder 0.4g; Lac regis apis lyophilized powder 0.4g
Adopt the preparation tablets technology of Fig. 3, the prescription of compositions 5 is made tablet.
Wherein, the particle diameter of the 0.4g Haematocoocus Pluvialls microcapsule powder in the compositions 4 is 180 orders, is 18 purpose Haematocoocus Pluvialls powder 0.4g by particle diameter, forms behind landfill by 1.6g wall material.Specifically by above any method preparation.
Compositions 6: Radix Ginseng 0.5g; Haematocoocus Pluvialls microcapsule powder 0.5g; Lac regis apis lyophilized powder 0.5g
Adopt the preparation tablets technology of Fig. 3, the prescription of compositions 6 is made tablet.
Wherein, the particle diameter of the 0.5g Haematocoocus Pluvialls microcapsule powder in the compositions 6 is 120 orders, is 12 purpose Haematocoocus Pluvialls powder 0.5g by particle diameter, forms behind landfill by 2g wall material.Specifically by above any method preparation.
Effect embodiment 1
The human feeding trial method:
Selected for 60 example ages in the healthy women effect object of study of one's mid-40s, after obtaining they agree unanimously, participate in.Consider the individual variation of all objects, as the age, health, skin type and structure, the experimenter is divided into three groups of i.e. test groups and placebo Comparative Examples respectively, measures the skin parameter.Every group of 20 examples, the experimenter gives 1 group of compositions 2 times respectively every day; 2 groups of compositionss; 3 groups of compositionss.Test period was 6 weeks.Three points are carried out in each test event measurement, i.e. during research beginning, after 3 weeks and after 6 weeks.All tests all use single blind method to carry out.
Experimental apparatus: German CK MPA-580Visia face-image analyser
Detect index: xerosis cutis degree, water content, smoothness, elasticity, wrinkle
After 6 weeks, the experimenter is in oral intact each component, and self is to the assessment of skin improvement situation work, and concrete parameter comprises xerosis cutis, water content, roughness, elasticity and wrinkle.
After 6 weeks, the overall degree of improving of skin is seen Fig. 4, Fig. 5, Fig. 6, Fig. 7.Result by Fig. 4, Fig. 5 shows: improving aspect the skin skin matter through 6 week backs, general effect is evaluated as: compositions 1＞Haematocoocus Pluvialls sheet＞Radix Ginseng slice＞queen bee lodicule＞placebo, fully show compositions of the present invention improve aspect the skin effects evident in efficacy.Result by Fig. 6, Fig. 7 shows: improving aspect the skin skin matter through 6 week backs, general effect is evaluated as: compositions 2＞compositions 1＞placebo, fully show compositions of the present invention improve aspect the skin effects evident in efficacy, proved further also simultaneously that adopting microcapsule technology is that the raising effect is arranged to the stability of Haematocoocus Pluvialls powder itself, the while also also increases significantly to quality and the efficacy effect of product.
Effect embodiment 2
To the xerosis cutis degree, the effect evaluation of wrinkle is estimated the research staff in oral the 3rd week of experimenter by the effect of specialty and was compared in the 6th week.Adopt the skinanalysis apparatus of above-mentioned specialty to compare.The results are shown in down Fig. 8, Fig. 9.Going up data by figure can find out, Orally administered composition 1, compositions 2, placebo, and in the 3rd week, the 6th week all was lower than baseline in xerosis cutis degree mean scores, and namely oral preceding score value shows that taking the 3rd all backs xerosis cutis degree all has improvement.But it is not obvious that placebo group is improved, yet from the effect of real improvement, compositions 2 will fully show significantly better than compositions 1 and placebo group, and is more obvious through the composition effect of microcapsule technology preparation.
From Fig. 8, Fig. 9 data show, Orally administered composition 2＞compositions 1＞placebo, Orally administered composition 1 plays certain effect of improving aspect the wrinkle of skin improving, further, Orally administered composition 2 obviously is better than preceding two groups in that to improve aspect the wrinkle of skin effect more remarkable.Also proved absolutely, improved remarkably productive effect aspect the wrinkle of skin through the compositions of microcapsule technology preparation.
In sum, adopt the health product of ternary composition of the present invention can possess anti-aging effects very effectively, thereby can significantly improve skin aging, as improve skin coarseness, wrinkle of skin, skin elasticity, moisture of skin etc.Further, adopt and the Haematocoocus Pluvialls powder in the compositions to be carried out microcapsule handle, the senile-resistant efficacy of enhancing composition more more significantly, thus possess outstanding technique effect.
More than specific embodiments of the invention are described in detail, but it is just as example, the present invention is not restricted to specific embodiment described above.To those skilled in the art, any equivalent modifications that the present invention is carried out and substituting also all among category of the present invention.Therefore, not breaking away from impartial conversion and the modification of doing under the spirit and scope of the present invention, all should contain within the scope of the invention.
Claims (10)
1. a Haematocoocus Pluvialls microcapsule powder is in the preparation treatment or prevent application in antidotal medicine or the health product.
2. application as claimed in claim 1 is characterized in that: described Haematocoocus Pluvialls microcapsule powder comprises Haematocoocus Pluvialls powder and beta-schardinger dextrin-.
3. application as claimed in claim 2 is characterized in that: the particle diameter of described Haematocoocus Pluvialls powder is the 10-20 order, and the particle diameter of described Haematocoocus Pluvialls microcapsule powder is the 100-200 order.
4. application as claimed in claim 2 is characterized in that: the weight ratio of described Haematocoocus Pluvialls powder and beta-schardinger dextrin-is 1:4.
5. application as claimed in claim 2 is characterized in that: described Haematocoocus Pluvialls microcapsule powder is by molecular inclusion, spray drying method, and squeezing and pressing method or spraying are congealed the method preparation and are got.
6. application as claimed in claim 1 is characterized in that: described medicine or health product also comprise Radix Ginseng, Lac regis apis lyophilized powder and filler.
7. application as claimed in claim 6 is characterized in that: the content of described Radix Ginseng is than being the 0.05-0.5 weight portion, and described content ratio with the Haematocoocus Pluvialls chemical compound is the 0.01-0.5 weight portion, and the content of described Lac regis apis lyophilized powder is than being the 0.05-0.5 weight portion.
8. application as claimed in claim 7 is characterized in that: the content of described Radix Ginseng is than being the 0.1-0.4 weight portion, and described content ratio with the Haematocoocus Pluvialls chemical compound is the 0.05-0.4 weight portion, and the content of described Lac regis apis lyophilized powder is than being the 0.1-0.4 weight portion.
9. application as claimed in claim 8 is characterized in that: described Radix Ginseng, the weight ratio of Haematocoocus Pluvialls chemical compound and Lac regis apis lyophilized powder are 3:5:4.
10. as each described application of claim 1-9, it is characterized in that described antidotal efficacy performance is for improving skin coarseness, skin dryness, wrinkle of skin, skin elasticity.
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| CN2013101798692A CN103271950A (en) | 2013-05-15 | 2013-05-15 | Application of haematococcus pluvialis microcapsule powder |
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| CN2013101798692A CN103271950A (en) | 2013-05-15 | 2013-05-15 | Application of haematococcus pluvialis microcapsule powder |
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| CN104856051A (en) * | 2015-04-10 | 2015-08-26 | 杭州鑫伟低碳技术研发有限公司 | Method for producing microcapsules of astaxanthin powder by utilizing haematococcus pluvialis |
| CN106473114A (en) * | 2015-08-24 | 2017-03-08 | 广州硕维食品技术有限公司 | A kind of anti-apolexis composition |
| CN105394749A (en) * | 2015-10-23 | 2016-03-16 | 武汉龙族药号生物医药科技有限公司 | Formula, preparation method and application of astaxanthin-containing health food |
| CN105394749B (en) * | 2015-10-23 | 2018-03-20 | 武汉龙族药号生物医药科技有限公司 | A kind of Ricipe for health care food and preparation method and application containing astaxanthin |
| CN105533518A (en) * | 2016-01-21 | 2016-05-04 | 南京呈鼎生物科技有限公司 | Haematococcus-cyclodextrin composition and preparation method thereof, and preparation |
| CN105661397A (en) * | 2016-01-21 | 2016-06-15 | 南京呈鼎生物科技有限公司 | Fruit, vegetable and cyclodextrin supermolecule micro-powder, method for preparing same and application of fruit, vegetable and cyclodextrin supermolecule micro-powder |
| CN105661523A (en) * | 2016-01-30 | 2016-06-15 | 合肥华方医药科技有限公司 | Colla corii asini taste masking freeze-dried powder, preparation method and application |
| CN105901573A (en) * | 2016-04-27 | 2016-08-31 | 青岛旭能生物工程有限责任公司 | Nannochloropsis salina oil powder containing capsule and preparation method thereof |
| CN107375148B (en) * | 2017-08-16 | 2018-07-10 | 佐登妮丝（广州）美容化妆品有限公司 | A kind of skin repair composition |
| CN108420056A (en) * | 2018-02-07 | 2018-08-21 | 北京罗麦科技有限公司 | A kind of composition of beautifying face and moistering lotion and products thereof |
| CN110870842A (en) * | 2018-08-29 | 2020-03-10 | 伽蓝（集团）股份有限公司 | Application of haematococcus pluvialis extract |
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