CN103250727B - Agricultural insecticidal composition containing indoxacarb and ZJ4042 - Google Patents

Abstract

The invention discloses an agricultural insecticidal composition containing active ingredients, namely indoxacarb and 3-chloro-N1-(2-methyl-4-heptafluoroisopropyl phenyl)-N2-(1-methyl-1-cyanoethyl)phthalimide which are in the weight ratio of (1-50): (20-1). The insecticidal composition disclosed by the invention is suitable for preventing and treating destructive insects, such as spodoptera litura, beet armyworm, diamondback moth, cnaphalocrocis medinalis and cotton bollworm, of crops. According to the agricultural insecticidal composition, the quick acting performance and effect lasting performance are better than those of single agents, and the dosage and medicating cost of insecticide are reduced, so that the environmental protection and comprehensive treatment on agricultural insects are facilitated.

Description

An agricultural insecticidal composition containing indoxacarb and ZJ4042

technical field

The present invention belongs to the field of pesticides, and specifically relates to a compound composed of indoxacarb and 3-chloro-N ¹ -(2-methyl-4-heptafluoroisopropylphenyl)-N ² -(1-methyl-1- A high-efficiency and low-toxicity pesticide composition compounded with cyanoethyl) phthalamide and its insecticide.

Background technique

The problem of resistance to agricultural pests is a global problem. With the continuation of chemical control of pests, the increase in the use of pesticides and the unscientific use of pesticides, the resistance of pests is becoming more and more serious, and the types of resistant pests are increasing. Especially the lepidopteran pests that seriously damage agricultural production have a high degree of resistance and a rapid development of resistance. At the same time, the high-intensity use of pesticides has led to excessive pesticide residues in agricultural products, environmental pollution, and increased pesticide costs for farmers, which is not conducive to the sustainable development of agriculture. Therefore, it is necessary to research and develop highly efficient, low-toxic, and environmentally friendly insecticides and pesticides.

Indoxacarb is a new type of high-efficiency insecticide of the oxadiazine class. It is a new type of green pesticide with multiple effects on neuronal nAchRS and GABA receptors with sodium channels as the main target. It has high efficiency, high selectivity, Low residue and other characteristics, no cross-resistance with other insecticides, can effectively control a variety of pests on grain, cotton, fruit, vegetables and other crops.

3-chloro-N ¹ -(2-methyl-4-heptafluoroisopropylphenyl)-N ² -(1-methyl-1-cyanoethyl)phthalamide (test code: ZJ4042 ), is a new type of insecticide developed by Zhejiang Research Institute of Chemical Industry, and its structural formula is shown in (I):

The insecticidal activity of ZJ4042 is basically equivalent to that of the recently developed flubendiamide. It has a broad-spectrum control effect on Lepidoptera pests and has no cross-resistance with existing insecticides. It is very suitable for existing insecticides to produce resistance. Sexual pest control.

When indoxacarb and ZJ4042 are used alone, the drug cost is high, which limits their popularization and application to a certain extent, and the long-term single use is likely to cause the continuous increase of pest resistance. Mixing of different pesticide varieties is a common method to control agricultural resistant pests. Through the screening of pesticide formulas, screening out reasonable formulas can effectively improve the actual control effect, reduce the dosage of pesticides, reduce costs, delay the emergence of pest resistance, and prolong the service life of pesticides. It is an important means of integrated pest management.

The mixture of indoxacarb and ZJ4042 has not been reported and applied to control Lepidoptera pests such as Spodoptera litura, Spodoptera litura, Diamondback moth, Rice leaf roller, Cotton bollworm and so on.

Contents of the invention

The purpose of the present invention is to provide a high-efficiency, low-toxicity, long-lasting, effective control of crop lepidopteran pests and low cost of pesticide composition and insecticide.

For achieving the purpose of the invention, the technical scheme adopted by the present invention is:

An insecticidal composition for agricultural pests, containing two active ingredients, the first active ingredient is indoxacarb, and the second active ingredient is 3-chloro-N ¹ -(2-methyl-4-hepta Fluoroisopropylphenyl)-N ² -(1-methyl-1-cyanoethyl)phthalamide, the weight ratio of the first active ingredient to the second active ingredient is 1-50 : 20~1.

The weight ratio of the above-mentioned one active ingredient to the second active ingredient is preferably 1-10:10-1, more preferably 1-5:5-1.

The present invention also provides an insecticide for agricultural pests, which contains 5-90% of the above-mentioned insecticidal composition by weight, and the rest are agriculturally acceptable carriers and adjuvants. As a preferred embodiment, the insecticide preferably contains 5 to 40% of the above insecticidal composition.

The carrier of the present invention can be solid or liquid, and any carrier commonly used for preparing pesticide compositions can be used.

Suitable solid carriers include: minerals, plants, synthetic fillers and inorganic salts. The minerals include silicates, carbonates, sulfates and oxides. Silicates such as kaolin, sepiolite, nacrite, montmorillonite, mica, vermiculite, pyrophyllite, talc. Carbonates such as: calcium carbonate, dolomite. Sulfates such as ammonium sulfate, sodium sulfate, calcium sulfate. Oxides such as quicklime, magnesium lime, diatomaceous earth. Vegetables such as: citrus pomace, corn cob, chaff powder, rice husk, soybean straw powder, tobacco powder, walnut shell, sawdust. Synthetic fillers such as precipitated calcium carbonate hydrate, precipitated calcium carbonate, white carbon black. Inorganic salts such as potassium chloride, sodium chloride.

Liquid carriers include water and organic solvents. When the active ingredient is suspoemulsion, the organic solvent plays the role of solubilization and antifreeze. Suitable organic solvents include aromatics such as benzene, xylene, toluene, alkylbenzenes, alkylnaphthalenes, and chlorinated aromatics; chlorinated aliphatics such as vinyl chloride, chloroform, methylene chloride, chloroform, carbon tetrachloride and polychloroethanes; aliphatic hydrocarbons such as petroleum distillates, cyclohexane, light mineral oils and paraffins. Alcohols such as methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerol, fatty alcohols, etc.; ethers such as methyl glycol ether, ethyl glycol ether, petroleum ether. Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone and isophorone, N-methyl-pyrrolidone; special solvents also include dimethylformamide, dimethyl sulfoxide, polyethylene glycol , has been nitrile; vegetable oil and methylated vegetable oil. The above-mentioned organic solvents may be used alone, or in combination, or in combination with water.

The auxiliary agent of the present invention may include one or more of surfactants, defoamers, thickeners, suspending agents and antifreezing agents as required, and may also include other auxiliary agents commonly used in this industry as required.

Surfactants can be emulsifiers, dispersants, stabilizers or wetting agents; can be ionic or nonionic. Suitable surfactants include: sodium and calcium salts of polyacrylic acid and lignosulfonic acid; polycondensation products of fatty acids or fatty amines having at least 12 carbon atoms in the molecule with ethylene oxide and/or propylene oxide; glycerol, Fatty acid esters of 1-lauryl alcohol, 1-myristyl alcohol, sorbitol, sucrose or pentaerythritol; and their polycondensation products with ethylene oxide and/or propylene oxide; sulfate salts or Sulfonates; alkali or alkaline earth metal salts, preferably sodium, of sulfuric or sulfonic acids containing at least 10 carbon atoms in the molecule, such as sodium lauryl sulfate, sodium secondary alkyl sulfate, ricinium sulfonate Sodium salt of sesame oil, sodium alkylarylsulfonate and sodium dodecylbenzenesulfonate; polymer of ethylene oxide, copolymer of ethylene oxide and propylene oxide.

Emulsifiers include nonionic emulsifiers and anionic emulsifiers. Non-ionic emulsifiers are preferably nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, styrylphenyl polyoxyethylene ether, alkylphenol formaldehyde resin polyoxyethylene ether, hydroxyl-terminated polyoxyethylene polyoxypropylene ether , Styryl phenol formaldehyde resin polyoxyethylene polyoxypropylene ether, castor oil polyoxyethylene ether. Anionic emulsifiers mainly include calcium dodecylbenzenesulfonate, tristyrylphenol polyoxyethyl ether phosphate amine salt, nonylphenol polyoxyethylene ether phosphate amine salt, castor oil polyoxyethylene ether phosphate amine salt .

The dispersant of the present invention includes: acrylic acid homopolymer sodium salt, maleic acid disodium salt, naphthalene sulfonate formaldehyde condensate sodium salt, rosin block polyoxyethylene ether polyoxypropylene ether sulfonate, hydroxyl-terminated poly One or more of oxyethylene polyoxypropylene ether block copolymer, tristyrylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphoric acid, and sodium p-hydroxyphenyl lignosulfonate.

The wetting agent described in the present invention includes: one or more combinations of fatty alcohol polyoxyethylene ether, naphthalene sulfonate, sodium lauryl sulfate, and alkylphenol resin polyoxyethylene ether sulfate.

The thickener of the present invention includes one or more of xanthan gum, magnesium aluminum silicate, sodium alginate, sodium carboxymethylcellulose, gum arabic, gelatin and polyvinyl alcohol. The defoaming agent described in the present invention is preferably: foam enemy, silicones, C _{8 ~ 10} fatty alcohols, C _{10 ~ 20} saturated fatty acids and amides, etc.

The pesticidal composition of the present invention can be formulated into emulsifiable concentrates, oil suspensions, suspension concentrates, wettable powders or water-dispersible granules according to common methods in the art.

The insecticidal composition of the present invention is particularly suitable for controlling Lepidoptera pests in plants such as vegetables, rice or cotton, including Spodoptera litura, Spodoptera litura, diamondback moth, rice leaf roller, cotton bollworm and the like.

Compared with the prior art, the insecticidal composition of the present invention has the following advantages:

(1) The combination of the two insecticides in the composition exhibits excellent synergistic effect within a certain ratio range, and the insecticidal effect of the mixed composition is significantly improved compared with its single agent, and has good quick-acting properties and long-lasting characteristics;

(2) Reduce the dosage and reduce the cost of medication for farmers;

(3) Using two kinds of pesticides to rationally mix different modes of action and different mechanisms of action on pests can not only prolong the service life of pesticides, but also delay the emergence of pest resistance.

Detailed ways

The present invention will be further described below in conjunction with specific examples, but the present invention is not limited to these specific implementations. Those skilled in the art will realize that the present invention covers all alternatives, modifications and equivalents as may be included within the scope of the claims.

The selection of material formulations in the following examples can be adapted to local conditions and has no substantial impact on the results. In these examples, all percentages are by weight unless otherwise indicated.

The inventors conducted an indoor toxicity test on the mixture of indoxacarb and ZJ4042.

The test refers to the Indoor Bioassay Test Guidelines for Insecticides and Pesticides (Agricultural Industry Standard NY/T1154.7-2006) and the creation of Pesticide Biological Activity Evaluation SOP (Insecticide Volume), using the dipping method.

The combined effect is calculated using the following method:

Theoretical mixture toxicity index (TTI) = toxicity index of A × content of A in the mixture (%)

Toxicity index of +B × B content in the mixture (%)

If the co-toxicity coefficient is greater than 120, it indicates a synergistic effect; if it is less than 80, it indicates an antagonistic effect; if it is greater than 80 but less than 120, it indicates an additive effect.

Example 1: Example of mixing ZJ4042 and indoxacarb

Table 1 Combined synergistic effect of ZJ4042 and indoxacarb on Plutella xylostella

deal with Proportion _LC50 (mg/L) measured toxicity index theoretical virulence index co-toxicity coefficient Indoxacarb - 1.32 28.03

ZJ4042 - 0.37 100.00 Indoxacarb: ZJ4042 50:20 0.58 63.79 48.59 131.28 Indoxacarb: ZJ4042 50:1 0.92 40.22 29.44 136.60 Indoxacarb: ZJ4042 20:1 0.83 44.58 31.46 141.71 Indoxacarb: ZJ4042 10:1 0.82 45.12 34.57 130.51 Indoxacarb: ZJ4042 5:1 0.71 52.11 40.03 130.20 Indoxacarb: ZJ4042 1:1 0.42 88.10 64.02 137.62 Indoxacarb: ZJ4042 1:5 0.31 119.35 88.01 135.62 Indoxacarb: ZJ4042 1:10 0.27 137.04 93.46 146.63 Indoxacarb: ZJ4042 1:20 0.28 132.14 96.57 136.83

Table 2 Combined synergistic effect of ZJ4042 and indoxacarb on Cnaphalocrocis medinalis

deal with Proportion _LC50 (mg/L) measured toxicity index theoretical virulence index co-toxicity coefficient Indoxacarb - 7.59 17.00 ZJ4042 - 1.29 100.00 Indoxacarb: ZJ4042 50:20 2.37 54.43 40.71 133.70 Indoxacarb: ZJ4042 50:1 4.89 26.38 18.62 141.65 Indoxacarb: ZJ4042 20:1 4.27 30.21 20.95 144.21 Indoxacarb: ZJ4042 10:1 4.05 31.85 24.54 129.79 Indoxacarb: ZJ4042 5:1 3.21 40.19 30.83 130.35 Indoxacarb: ZJ4042 1:1 1.52 84.87 58.50 145.08 Indoxacarb: ZJ4042 1:5 1.02 126.47 86.17 146.78

Indoxacarb: ZJ4042 1:10 0.98 131.63 92.45 142.38 Indoxacarb: ZJ4042 1:20 0.91 141.76 96.05 147.59

It can be seen from Tables 1 and 2 of the test results that indoxacarb and ZJ4042, within the range of 1-50:20-1 (by weight ratio), have a co-toxicity coefficient greater than 120, which is effective against cabbage diamondback moth and rice longitudinal roll moth. Leaf borer showed a synergistic effect. The mixing of indoxacarb and ZJ4042 is reasonable and feasible.

Example 2 (20% indoxacarb ZJ4042 suspension concentrate)

Indoxacarb 18%, ZJ404 22%, emulsifier 1601# (styrylphenol polyoxyethylene polyoxypropylene ether) 10%, dispersant SOPA-27044%, bentonite 2%, xanthan gum 0.1%, organic silicon disinfectant Foaming agent 0.4%, glycerin 5%, the balance is deionized water. The above formula is pre-crushed according to the proportion, then added to a sand mill for grinding, and prepared after high-shear mixing to prepare 20% indoxacarb·ZJ4042 suspension concentrate.

This embodiment is applied to control Plutella xylostella. 20% indoxacarb·ZJ4042 suspension was sprayed uniformly with water at 10 g/mu on the larvae of Plutella xylostella xylostella, and the control effects were 92.3% and 94.7% at 3 days and 7 days after spraying. Control single dose of 15% indoxacarb SC (15 g/mu) and 20% ZJ4042 SC (10 g/mu) were sprayed in the same way, and the control effects after 3 days were respectively 71.2%, 85.7%, 7 days after the drug control effect were 74.3%, 87.9%. After mixing indoxacarb and ZJ4042, the synergistic effect is obvious, and the control effect is better than that of single agent.

Example 3 (40% indoxacarb ZJ4042 water dispersible granules)

According to indoxacarb 35%, ZJ40425%, sodium lauryl sulfate 6%, polysulfate 4%, sodium chloride 8%, polyethylene glycol 3%, the balance is kaolin. Dry pulverize, granulate, dry and sieve the above formula in proportion to prepare 40% indoxacarb·ZJ4042 water-dispersible granules.

This embodiment is applied to control Spodoptera litura. 40% indoxacarb·ZJ4042 water dispersible granules were sprayed uniformly with water at 10 g/mu at the peak of Spodoptera litura larvae occurrence, and the control effects were 90.2% and 91.7% at 3 days and 7 days after spraying. Control single dose of 15% indoxacarb SC (15 g/mu) and 20% ZJ4042 SC (10 g/mu) were sprayed in the same way, and the control effects after 3 days were respectively 71.7%, 85.1%, 7 days after the drug control effect was 72.9%, 86.4%. After mixing indoxacarb and ZJ4042, the synergistic effect is obvious, the control effect is better than that of a single dose, the quick-acting and long-lasting effects are also better than a single dose, and the dosage is lower than that of a single dose.

Example 4 (70% indoxacarb ZJ4042 water dispersible granules)

According to indoxacarb 55%, ZJ404215%, sodium lauryl sulfate 6%, polysulfate 4%, sodium chloride 8%, polyethylene glycol 3%, and the balance is kaolin. Dry pulverize, granulate, dry and sieve the above formula in proportion to prepare 70% indoxacarb·ZJ4042 water-dispersible granules.

This embodiment is applied to control rice leaf roller. 70% indoxacarb·ZJ4042 water dispersible granules were sprayed evenly with water at 10 g/mu on the young larvae of rice leaf rollers during the full-bloom stage, and the control effects were 87.5% and 91.3% 7 days and 14 days after spraying. Control single dose of 15% indoxacarb SC (15 g/mu) and 20% ZJ4042 SC (10 g/mu) were sprayed in the same way, and the control effects after 7 days were respectively 70.8%, 82.9%, 14 days after the drug control effect was 72.3%, 86.2%. After mixing indoxacarb and ZJ4042, the synergistic effect is obvious, the control effect is better than single agent, and the quick-acting and long-lasting effects are also better than single agent.

Example 5 (40% indoxacarb ZJ4042 wettable powder)

According to indoxacarb 35%, ZJ40425%, sodium lauryl sulfate 6%, polysulfate 4%, sodium chloride 8%, polyethylene glycol 3%, the balance is kaolin. Dry pulverize, granulate, dry and sieve the above formula in proportion to prepare 40% indoxacarb·ZJ4042 wettable powder.

This embodiment is applied to control rice leaf roller. 40% indoxacarb·ZJ4042 wettable powder was sprayed uniformly with water at 10 g/mu at the peak of the young larvae of the rice leaf roller, and the control effects were 92.3% and 93.0% at 7 days and 14 days after spraying. Control single dose of 15% indoxacarb SC (15 g/mu) and 20% ZJ4042 SC (10 g/mu) were sprayed in the same way, and the control effects after 7 days were respectively 70.8%, 82.9%, 14 days after the drug control effect was 72.3%, 86.2%. After mixing indoxacarb and ZJ4042, the synergistic effect is obvious, the control effect is better than single agent, and the quick-acting and long-lasting effects are also better than single agent.

Example 6 (20% indoxacarb ZJ4042 oil suspension)

Indoxacarb 15%, ZJ40425%, castor oil polyoxyethylene ether 13%, tristyrylphenol polyoxyethylene ether phosphate 3%, organic bentonite 1%, methyl oleate to 100%. After the above formula is mixed evenly, it can be sanded to a certain particle size.

This embodiment is applied to control cotton bollworm. 20% indoxacarb·ZJ4042 oil suspension was sprayed evenly with water at 10 g/mu at the peak stage of cotton bollworm larvae, and the control effects were 90.2% and 93.5% at 3 days and 7 days after spraying. Control single dose of 15% indoxacarb SC (15 g/mu) and 20% ZJ4042 SC (10 g/mu) were sprayed in the same way, and the control effects after 3 days were respectively 72.5%, 83.9%, 7 days after the drug control effect was 73.9%, 88.6%. After mixing indoxacarb and ZJ4042, the synergistic effect is obvious, and the control effect is better than that of single agent.

Example 7 (20% indoxacarb ZJ4042 EC)

Indoxacarb 15%, ZJ404 25%, calcium dodecylbenzenesulfonate 6%, tristyrylphenol polyoxyethylene ether 6%, NMP 8%, and the balance is xylene. Mix the above formula in proportion and stir evenly.

This embodiment is applied to control beet armyworm. 20% indoxacarb·ZJ4042 oil suspension was sprayed evenly with water at 10 g/mu in the peak stage of beet armyworm larvae, and the control effects were 92.3% and 94.2% at 3 days and 7 days after spraying. Control single dose of 15% indoxacarb SC (15 g/mu) and 20% ZJ4042 SC (10 g/mu) were sprayed in the same way, and the control effects after 3 days were respectively 71.6%, 80.7%, and 72.7%, 84.7% after 7 days of drug control. After mixing indoxacarb and ZJ4042, the synergistic effect is obvious, and the control effect is better than that of single agent.

Claims (8)

1. An insecticidal composition for agricultural pests, characterized in that it contains two active ingredients, the first active ingredient is indoxacarb, and the second active ingredient is 3-chloro-N ¹ -(2-formazan base-4-heptafluoroisopropylphenyl)-N ² -(1-methyl-1-cyanoethyl)phthalamide, the weight of the first active ingredient and the second active ingredient The ratio is 1-50:20-1. 2. The insecticidal composition for agricultural pests according to claim 1, characterized in that the weight ratio of the first active ingredient to the second active ingredient is 1-10:10-1. 3. The insecticidal composition for agricultural pests according to claim 2, characterized in that the weight ratio of the first active ingredient to the second active ingredient is 1-5:5-1. 4. An insecticide for agricultural pests, characterized in that it contains 5-90% by weight of the insecticidal composition of claim 1, and the rest are agriculturally acceptable carriers and adjuvants. 5. The insecticide for agricultural pests according to claim 4, characterized in that it contains 5 to 40% of the insecticidal composition according to claim 1 by weight. 6. The insecticide for agricultural pests according to claim 4, characterized in that the insecticide can be configured as emulsifiable concentrate, oil suspension, suspension concentrate, wettable powder or water-dispersible granule. 7. According to the application of the insecticidal composition described in any one of claims 1-6, it is characterized in that the insecticidal composition is used to control Lepidoptera pest Spodoptera litura, beet armyworm, diamondback moth, rice vertical Leaf rollers and cotton bollworms. 8. The application of the insecticidal composition according to claim 7, characterized in that the insecticidal composition is used for controlling Lepidoptera pests in vegetables, rice or cotton.