CN103239426A - Preparation of a kind of far-infrared gel composition and gel ointment - Google Patents

Abstract

The invention relates to the technical field of medical plasters, and specifically discloses the preparation of a medicinal gel composition (paste) and gel plaster. Based on the total weight of the gel composition, it contains the following components: 3-7 wt% of far-infrared material, 20-35 wt% of plant extract, 1-4 wt% of acrylic resin, 0.1-0.4 wt% of crosslinking agent, 20-35wt% moisturizer, 1.5-3.0wt% skin penetration enhancer, 1-3wt% filler, 5-7wt% binder, and water as the balance; wherein the far-infrared material is selected from tourmaline or wheat Rice stone; the acrylic resin is selected from the copolymer of acrylic acid and sodium acrylate or sodium polyacrylate. The gel composition of the present invention has the function of magnetic therapy; at the same time, because of its unique formula and good cross-linking performance, there will be no ointment leakage during sticking, and it is convenient to use.

Description

Preparation of a kind of far-infrared gel composition and gel ointment

technical field

The invention relates to the technical field of medical plasters, and specifically discloses the preparation of a medicinal gel composition (paste) and gel plaster.

Background technique

Gel ointment (formerly known as cataplasm Gataplasma) originated from Japan in the 1970s and was introduced into my country in the early 1980s. In the 1990s, my country began to produce traditional Chinese medicine gel ointment on a large scale. The definition of gel ointment in the 2010 edition of "Chinese Pharmacopoeia" is: it refers to the plaster made by mixing the extract, decoction pieces or chemical drugs with a suitable hydrophilic matrix, and then coating on the backing material.

Gel ointment is an external patch with water-soluble polymer as the matrix and skeleton material. It has the advantages of large drug loading, reusable application, comfort, non-irritating and allergic, breathable and moisturizing, and good permeability. Since traditional Chinese medicines are all used as compound prescriptions, it is difficult to extract and purify the active ingredients. Most of them are extracted and refined into extracts of a certain concentration and then made into corresponding preparations to achieve the desired curative effect. The amount of medicine is large, and it can be peeled off repeatedly, and it can still maintain good viscosity when pasted again. Therefore, the application prospect of gel ointment in the field of pharmaceutical preparations is very wide.

Far-infrared radiation materials (hereinafter referred to as: far-infrared materials) such as tourmaline, medical stone, etc. and related products have been developed and marketed in China, such as Zhongke warm underwear, quilts, sheets, pillows, etc. of Zhongmai Technology. According to research, it has been confirmed that far infrared penetrates into the body, and through resonance absorption, it acts as a micro-massage. It has a non-thermal effect. This effect can expand local capillaries, promote cell expansion into a porous state, promote drug absorption, and accelerate microcirculation. Metabolism plays a therapeutic role in promoting blood circulation and removing blood stasis, and truly embodies the treatment principle of "general rule does not hurt" in the theory of traditional Chinese medicine. And tourmaline, medical stone etc. are also not reported as one of the active ingredients of the gel ointment for the treatment of acute and chronic sprains and soft tissue injury types.

Since certain ingredients in traditional Chinese medicine affect the crosslinking of the gel composition, this effect has always been a difficult problem to be solved in this field. This patent effectively solves the influence of certain components of traditional Chinese medicine in the gel ointment on the crosslinking performance. At the same time, far-infrared materials tourmaline powder, medical stone powder and other materials are introduced into the gel composition. On the basis of chronic sprains and soft tissue injuries, it also has certain physical therapy effects.

Contents of the invention

The present invention aims to provide a gel composition containing far-infrared materials of a specific formula, so that the gel ointment (cataplasm) with it as paste has physical (magnetic) therapeutic effects; It also has good cross-linking performance, so that the gel ointment using it as a paste will not appear the phenomenon of paste seepage when it is applied.

The second object of the present invention is to provide a preparation method of the above-mentioned gel composition.

The third object of the present invention is to provide a gel ointment containing the above gel composition.

In a first aspect of the present invention, a kind of far-infrared gel composition is provided, in terms of the total weight of the gel composition, it contains the following components:

Far-infrared material 3-7wt%, plant extract 20-35wt%, acrylic resin 1-4wt%, cross-linking agent 0.1-0.4wt%, moisturizer 20-35wt%, skin penetration accelerator 1.5-3.0wt%, filling 1-3wt% of the agent, 5-7wt% of the binder, and the balance is water;

Wherein the far-infrared material is selected from tourmaline or medical stone; the acrylic resin is selected from the copolymer of acrylic acid and sodium acrylate or sodium polyacrylate.

In another preferred example, the plant extract is prepared by mixing the extracts of three traditional Chinese medicines: hibiscus, capsicum and red bean.

In another preferred example, the crosslinking agent is selected from one or more of aluminum glyoxate, glycamino acid, or dicumyl peroxide.

In another preferred example, the humectant is selected from one or more of glycerin, propylene glycol, sorbitol, or polyethylene glycol.

In another preferred example, the skin penetration enhancer is selected from one or more of azone, propylene glycol, or eucalyptus oil.

In another preferred example, the filler is selected from one or more of kaolin, diatomaceous earth, or talc.

In another preferred example, the binder is selected from one or more of carboxymethylcellulose, sodium carboxymethylcellulose, polyvinyl alcohol, or polyvinylpyrrolidone.

In the second aspect of the present invention, a method for preparing the above-mentioned far-infrared gel composition of the present invention is provided.

In the third aspect of the present invention, a gel paste is provided, which contains the above-mentioned far-infrared gel composition of the present invention.

Details of various aspects of the invention are set forth in the ensuing sections. The features, objects and advantages of the present invention will be more apparent from the following description and claims.

Detailed ways

After extensive and in-depth research, the inventor unexpectedly discovered a gel composition containing far-infrared materials, plant extracts, moisturizing agents, cross-linking agents, acrylic resins, fillers, adhesives and other components. When the content of these components is in an appropriate range, the resulting gel composition can release far infrared rays, so that the gel ointment with it as paste has physical (magnetic) therapeutic effects; The compound has good cross-linking properties, so that the gel ointment using it as a paste will not leak the paste when it is applied, and it is convenient to use.

Far infrared material

The far-infrared materials used in the present invention include tourmaline, medical stone, biochar and the like. They absorb the heat of the human body and release far-infrared rays, negative ions, sub-ions, mineral elements and other substances. The released far-infrared rays act on the human body, produce resonance absorption and penetrate cortical tissue, directly act on blood vessels and nerves, trigger the human body to generate energy that causes tissue excitement, and produce non-thermal effects, resulting in telangiectasia, increased microcirculatory blood flow, and promote Whole body blood circulation and metabolism, so as to play the effect of treating chronic diseases. In addition, the self-heating effect of the far-infrared material itself also has the effect of improving the thermal sensation of the thermal gel paste. The preferred far-infrared materials used in the present invention are tourmaline, medical stone and the like. Its dosage range is 3～7wt%, and the preferred range is 3.2～6.8wt%

Plant (Chinese Medicine) Extract

The plant extracts used in the present invention can be directly extracted from various Chinese medicinal plants by conventional methods in the field such as water extraction, organic solvent extraction, supercritical extraction, etc.; various plant extracts can also be mixed for use. It is preferable to use a mixed extract including three plant extracts of hibiscus, capsicum, and red bean (as used in the examples). The combination of the above drugs has good effects on detumescence, blood circulation, and pain relief. Its usage range is 20-35wt%, and the preferred range is 22-33wt%.

Acrylic

Acrylic resin pharmaceutical excipients used in the present invention include a class of acrylic acid (or methacrylic acid and their esters such as: methyl ester, ethyl ester, etc.) polymerized in bulk (a monomer), or with methacrylic acid (or Its esters (such as: methyl ester, ethyl ester, dimethylamino ethyl ester, etc.) are polymer compounds formed by copolymerization of two monomers (binary) in a certain proportion. The present invention preferably uses "partially neutralized polyacrylic acid" (that is, "copolymer of acrylic acid and sodium acrylate", such as Viscomate NP600, NP700, NP800), and the dosage range is 1 to 4 wt%, and the preferred range is 1.2 to 3.8 wt%. .

crosslinking agent

Most of the crosslinking agents for gel pastes commonly used in this field are high-valent metal salts, mainly aluminum salts, such as crystalline aluminum chloride, aluminum sulfate, aluminum glycinate, alum or composite aluminum salts. The cross-linking agent preferably used in the present invention is aluminum glycolate, glycine amino acid, dicumyl peroxide and the like. The dosage range is 0.1-0.4wt%, and the preferred range is 0.12-0.38wt%.

moisturizer

The water content of the gel paste is large, and solving the problem of moisturizing and water retention is an important link in the preparation of the gel paste. The humectant can dissolve, complex and associate with the water in the gel ointment, prevent the evaporation and loss of water, maintain the water content, and prevent the balance and stability of the ointment matrix from being damaged. Therefore, it is very important to choose a suitable moisturizer. Preferred humectants for use in the present invention include glycerin, propylene glycol, sorbitol, polyethylene glycol, and the like. The dosage range is 20-35wt%, and the preferred range is 20-33wt%.

Skin penetration enhancer

Transdermal absorption enhancers refer to all substances that can increase the rate of drug transdermal absorption or increase the amount of drug transdermal. Transdermal absorption enhancers commonly used in this field include dimethyl sulfoxide, azone, peppermint oil, borneol, eucalyptus oil, propylene glycol, and the like. The skin penetration enhancer preferably used in the present invention is azone, eucalyptus oil and the like. Its usage range is 1.5-3.0 wt%, preferably 1.7-2.8 wt%.

filler

The use of fillers in external plaster gel paste has the function of imparting and shaping the gel paste, and can improve the viscosity and plasticity, so that the gel paste can achieve the adhesion force that should be attached to the skin, and have the necessary cohesion to achieve the desired effect. There are technical requirements. The filler series used in the present invention are selected from kaolin, diatomaceous earth, talcum powder, graphite, carbon black, alumina powder, glass powder, asbestos powder, mica powder, quartz powder, carbon fiber, powdered cork, corundum and the like. Preferred fillers for use in the present invention include kaolin, diatomaceous earth, and talc. Its usage range is 1-3wt%, and the preferred range is 1.2-2.8wt%.

Adhesive

Adhesive is the main substance that produces the viscosity of gel paste, mostly composed of polymer compounds, which can be divided into natural water-soluble polymer substances and semi-synthetic and synthetic hydrophilic polymer substances according to their sources. Natural water-soluble polymer substances commonly used in this field include gelatin, tragacanth gum, acacia gum, agar, white gelatin, peach gum, starch, alginate and the like. Among them, gelatin has strong foaming property and good film-forming property. In non-crosslinked gel paste, it is often used as a gel skeleton component, but compared with agar, its coagulation force is weaker. The role of tragacanth gum and peach gum is mainly to increase the consistency of the matrix before molding, and at the same time to improve the adhesion of the gel ointment to the skin. Semi-synthetic and synthetic hydrophilic polymer adhesives commonly used are methyl cellulose, carboxymethyl cellulose and its sodium salt (CMC-Na), sodium polyacrylate, polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP ), carbomer, xanthan gum, etc. The preferred binding agent used in the present invention includes CMC-Na, PVP K-90 etc. Its usage range is 5-7wt%, and the preferred range is 5.2-6.8wt%.

In addition to the above ingredients, the gel composition of the present invention may also contain one or more other additives, such as preservatives, pH regulators and the like. Commonly used preservatives include, but are not limited to: benzoic acid (benzoic acid), LiquidGermall pus, adipic acid, anhydrous acetic acid, paraben, ethylparaben, propylparaben, paraben Butyl formate, isopropyl paraben, isobutyl paraben, borax, methyl salicylate, etc. Preservatives preferably used in the present invention are methyl salicylate, Liquid Germall pus. Its amount ranges from 0.1 to 1.5 wt%, preferably from 0.2 to 1.0 wt%. The pH regulator can adjust the pH value of the gel composition, including tartaric acid or citric acid and the like. Tartaric acid is preferably used in the present invention. Its amount ranges from 0.1 to 0.5 wt%, preferably from 0.12 to 0.48 wt%.

The gel composition of the present invention can be prepared by conventional methods in the art. First, take the moisturizing agent, crosslinking agent, adhesive, filler, transdermal absorption accelerator, far-infrared material, etc. of the formula to prepare the oil phase, and then take Prepare the water phase with the plant extract and water in the prescribed amount, then add the water phase into the oil phase and stir evenly. The prepared gel composition of the present invention is a viscous colloid with a certain cohesive force, which is evenly coated on the backing non-woven fabric, covered with an anti-adhesive film, placed, and allowed to further complete cross-linking, and finally passed After cutting and packaging, the clinically used sizing gel ointment can be obtained.

The far-infrared material contained in the gel composition of the present invention has a far-infrared emissivity of ≥ 88% (detected by a national authority), and an anion release of 1060/cm ³ . Due to the addition of far-infrared materials, the gel composition of the present invention has the function of magnetic therapy. The far-infrared rays, negative ions, sub-ions and mineral elements released by far-infrared materials such as tourmaline and medical stone are absorbed by the human body, which can promote the blood circulation and metabolism of the human body, thereby producing beauty, body and treatment of chronic diseases. At the same time, the gel composition of the present invention has good cross-linking performance due to its unique formula, no ointment leakage phenomenon occurs when sticking, and is convenient to use.

Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. All percentages, ratios, ratios, or parts are by weight unless otherwise indicated.

The units in the weight percent in the present invention are well known to those skilled in the art, for example, it refers to the weight of active ingredients contained in 100 weight units of the preparation, and the symbol is "wt%".

Unless otherwise defined, all professional and scientific terms used herein have the same meanings as commonly understood by those skilled in the art. In addition, any methods and materials similar or equivalent to those described can be applied to the method of the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only.

The above-mentioned features mentioned in the present invention, or the features mentioned in the embodiments can be combined arbitrarily. All the features disclosed in this patent specification can be used in combination with any combination, and each feature disclosed in the specification can be replaced by any alternative feature that can provide the same, equivalent or similar purpose. Therefore, unless otherwise specified, the disclosed features are only general examples of equivalent or similar features.

Embodiment 1 The gel composition is formed by mixing the following ingredients by weight:

The preparation method is as follows:

1. Preparation of oil phase: Accurately weigh the amount of glycerin, aluminum glycerol, CMC-Na, PVP K-90, NP600, kaolin, methyl salicylate, azone, eucalyptus oil, propylene glycol, tourmaline powder etc., put the above substances in an open container, stir and disperse evenly, and then place it for use;

2. Prepare the water phase: Accurately weigh the tartaric acid in the formula, add purified water, stir continuously to dissolve it, then add plant extracts, and continue stirring until the water phase becomes a uniform solution;

3. Prepare the gel paste base: quickly add the water phase to the oil phase, stir immediately, first stir quickly for 2 minutes, then stir at medium and slow speed for 6 minutes, at this time a viscous colloid with a certain cohesion is formed, spread the colloid evenly Put it on the backing non-woven fabric, cover it with anti-adhesive film, let it further complete the cross-linking. The gel ointment is obtained through cutting and packaging.

The excipient test was carried out on the prepared gel ointment paste, and the results showed that there was no flow phenomenon on the paste surface, which met the requirements.

Embodiment 2 The gel composition is composed of the following ingredients mixed by weight

The gel ointment was prepared according to the preparation method of Example 1. The excipient test was carried out on the gel ointment paste of the formula in this example, and the results showed that the paste surface did not flow, which met the requirements.

Embodiment 3 The gel composition is composed of the following ingredients mixed by weight

The gel ointment was prepared according to the preparation method of Example 1. The excipient test was carried out on the gel ointment paste of the formula in this example, and the results showed that the paste surface did not flow, which met the requirements.

Embodiment 4 The gel composition is formed by mixing the following ingredients by weight

The gel ointment was prepared according to the preparation method of Example 1. The excipient test was carried out on the gel ointment paste of the formula in this example, and the results showed that the paste surface did not flow, which met the requirements.

Example 5 The gel composition is composed of the following ingredients mixed by weight

The gel ointment was prepared according to the preparation method of Example 1. The excipient test was carried out on the gel ointment paste of the formula in this example, and the results showed that the paste surface did not flow, which met the requirements.

Embodiment 6 The gel composition is formed by mixing the following ingredients in a weight ratio

The gel ointment was prepared according to the preparation method of Example 1. The excipient test was carried out on the gel ointment paste of the formula in this example, and the results showed that the paste surface did not flow, which met the requirements.

Various aspects involved in the present invention have been described above. However, it should be understood that, without departing from the spirit of the present invention, equivalent changes and modifications can be made by those skilled in the art, and the changes and modifications also fall within the coverage of the claims of this patent application.

Claims (8)

1. a far-infrared gel composition, characterized in that, in terms of the total weight of the gel composition, it contains the following components: Far-infrared material 3-7wt%, plant extract 20-35wt%, acrylic resin 1-4wt%, cross-linking agent 0.1-0.4wt%, moisturizer 20-35wt%, skin penetration accelerator 1.5-3.0wt%, filling 1-3wt% of the agent, 5-7wt% of the binder, and the balance is water; Wherein the far-infrared material is selected from tourmaline or medical stone; the acrylic resin is selected from the copolymer of acrylic acid and sodium acrylate or sodium polyacrylate. 2. The far-infrared gel composition according to claim 1, characterized in that, said plant extract is formed by mixing the extracts of three kinds of Chinese medicines of hibiscus, capsicum and red bean. 3. The far-infrared gel composition according to claim 1, characterized in that, the crosslinking agent is selected from one or more of aluminum glycolate, glycine amino acid, or dicumyl peroxide. 4. The far-infrared gel composition according to claim 1, characterized in that, said humectant is selected from one or more of glycerin, propylene glycol, sorbitol, or polyethylene glycol. 5. The far-infrared gel composition according to claim 1, characterized in that, said transdermal accelerator is selected from one or more of azone, propylene glycol, or eucalyptus oil. 6. The far-infrared gel composition according to claim 1, characterized in that, the filler is selected from one or more of kaolin, diatomaceous earth, or talcum powder. 7. the far-infrared gel composition of claim 1, is characterized in that, described binding agent is selected from one or the other in carboxymethylcellulose, sodium carboxymethylcellulose, polyvinyl alcohol or polyvinylpyrrolidone Several kinds. 8. A gel paste, characterized in that the gel paste contains any far-infrared gel composition according to claims 1-7.