CN103212033B - Drug composition for treating viral hepatitis - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating viral hepatitis. The composition consists of astragalus, Codonopsis pilosula, Atractylodes macrocephala, Poria cocos, sealwort, Ganoderma lucidum, capillary, dandelion, gallbladder, isatidis, rhubarb, hedyotis diffusa, Polygonum multiflorum, Composed of raw materials such as Ziheche, Schisandra, Ligustrum lucidum, Polyporus, Radix Paeoniae Alba, and Salvia miltiorrhiza. The pharmaceutical composition of the present invention is prepared into clinically acceptable tablets, capsules, granules, pills, oral liquids or decoctions by adding conventional auxiliary materials according to conventional techniques. The pharmaceutical composition of the present invention has the effects of soothing the liver, protecting the liver, protecting the liver, clearing heat and promoting dampness, reducing jaundice and softening the liver, and has good therapeutic effects on the treatment of viral hepatitis, such as hepatitis B, liver cirrhosis, liver ascites, etc. The effect is remarkable and there are no toxic side effects.

Description

A kind of pharmaceutical composition for treating viral hepatitis

technical field

The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating viral hepatitis.

Background technique

So far, there is still a lack of recognized safe and effective drugs for viral hepatitis, especially hepatitis B, liver cirrhosis, and liver ascites. Some biological agents include "entecavir, lamivudine, telmivudine, adefovir, interferon, etc. Expensive, but efficacy is uncertain. It can only suppress the virus, and long-term use will cause the virus to mutate, and once the drug is stopped, it will cause severe severe hepatitis, which is recognized by the medical profession. my country is a big country producing natural Chinese herbal medicines, and the resources of Chinese herbal medicines are extremely rich. There are more than 12,000 kinds of Chinese herbal medicines that have been identified. Under the guidance of traditional Chinese medicine theory, the application of natural Chinese herbal medicines in the treatment of various liver diseases has a good effect. We are looking for ancient prescriptions and using traditional medicine. In TCM clinical medicine, according to syndrome, tongue, pulse, and dialectical prescriptions to treat liver diseases, we have achieved good curative effect. Although the research and application of traditional Chinese medicine for the treatment of viral hepatitis are extensive, the curative effect is not significant, the effect is single, the pertinence is poor, the treatment cycle is long, the recurrence rate is high, and it cannot treat both the symptoms and the root causes.

Contents of the invention

The purpose of the present invention is to provide a pharmaceutical composition for treating viral hepatitis.

The present invention is achieved through the following technical solutions:

The bulk drug of the pharmaceutical composition of the present invention consists of:

15-45 parts by weight of Radix Astragali, 15-45 parts by weight of Codonopsis Ginseng, 15-45 parts by weight of Atractylodes Rhizome

Poria cocos 15-45 parts by weight Polygonatum 15-45 parts by weight Ganoderma lucidum 15-45 parts by weight

Yin Chen 20-60 parts by weight, Dandelion 20-60 parts by weight, Gallbladder 7-23 parts by weight

10-30 parts by weight of Radix Radix, 5-15 parts by weight of Rhubarb, 10-30 parts by weight of Hedyotis diffusa

Polygonum multiflorum 7-23 parts by weight Ziheche 3-9 parts by weight Schisandra 10-30 parts by weight

Ligustrum lucidum 10-30 parts by weight, Polyporus 5-15 parts by weight, Radix Paeoniae Alba 15-45 parts by weight

Salvia 20-60 parts by weight Radix Paeoniae Rubra 15-45 parts by weight Sanqi 5-15 parts by weight

Turmeric 5-15 parts by weight, Bupleurum 7-23 parts by weight, Amomum 7-23 parts by weight

Pangolin 3-9 parts by weight, soft-shelled turtle 20-60 parts by weight, turtle plate 15-45 parts by weight

Licorice 5-15 parts by weight.

The bulk drug composition of the pharmaceutical composition of the present invention is preferably composed of:

30 parts by weight of Radix Astragali, 30 parts by weight of Codonopsis pilosula, 30 parts by weight of Atractylodes macrocephala

Poria cocos 30 weight parts Polygonatum 30 weight parts Ganoderma lucidum 30 weight parts

Yin Chen 40 parts by weight, Dandelion 40 parts by weight, Gallbladder 15 parts by weight

20 parts by weight of Radix Radix, 10 parts by weight of Rhubarb, 20 parts by weight of Hedyotis diffusa

Polygonum multiflorum 15 parts by weight Ziheche 6 parts by weight Schisandra chinensis 20 parts by weight

Ligustrum lucidum 20 parts by weight, Polyporus 10 parts by weight, Radix Paeoniae Alba 30 parts by weight

40 parts by weight of Salvia miltiorrhiza, 30 parts by weight of Radix Paeoniae Rubra, 10 parts by weight of Sanqi

Turmeric 10 parts by weight Bupleurum 15 parts by weight Amomum 15 parts by weight

Pangolin 6 parts by weight, soft-shelled turtle 40 parts by weight, turtle plate 30 parts by weight

Licorice 10 parts by weight.

The bulk drug composition of the pharmaceutical composition of the present invention is preferably composed of:

Astragalus 17 parts by weight Codonopsis 43 parts by weight Atractylodes macrocephala 17 parts by weight

Poria cocos 43 parts by weight Polygonatum 17 parts by weight Ganoderma lucidum 43 parts by weight

Yin Chen 25 parts by weight, Dandelion 55 parts by weight, Gallbladder 9 parts by weight

28 parts by weight of Radix Radix, 7 parts by weight of Rhubarb, 28 parts by weight of Hedyotis diffusa

Polygonum multiflorum 9 parts by weight Ziheche 7 parts by weight Schisandra chinensis 12 parts by weight

Ligustrum lucidum 28 parts by weight, Polyporus 7 parts by weight, Radix Paeoniae Alba 43 parts by weight

Salvia 25 parts by weight, Radix Paeoniae Rubra 43 parts by weight, Sanqi 7 parts by weight

Turmeric 13 parts by weight Bupleurum 9 parts by weight Amomum 21 parts by weight

Pangolin 4 parts by weight, soft-shelled turtle 55 parts by weight, turtle plate 17 parts by weight

Licorice 13 parts by weight.

The bulk drug composition of the pharmaceutical composition of the present invention is preferably composed of:

Astragalus 43 parts by weight Codonopsis 17 parts by weight Atractylodes macrocephala 43 parts by weight

Poria cocos 17 parts by weight Polygonatum 43 parts by weight Ganoderma lucidum 17 parts by weight

55 parts by weight of wormwood, 25 parts by weight of dandelion, 21 parts by weight of gallbladder

12 parts by weight of Radix Radix, 13 parts by weight of Rhubarb, 12 parts by weight of Hedyotis diffusa

Polygonum multiflorum 21 parts by weight Ziheche 5 parts by weight Schisandra chinensis 28 parts by weight

Ligustrum lucidum 12 parts by weight, Polyporus 13 parts by weight, Radix Paeoniae Alba 17 parts by weight

Salvia 55 parts by weight, Radix Paeoniae Rubra 17 parts by weight, Sanqi 13 parts by weight

Turmeric 7 parts by weight Bupleurum 21 parts by weight Amomum 9 parts by weight

Pangolin 7 parts by weight, soft-shelled turtle 25 parts by weight, turtle plate 43 parts by weight

Licorice 7 parts by weight.

The pharmaceutical composition of the present invention is prepared into clinically acceptable tablets, capsules, granules, pills, oral liquids or decoctions by adding conventional auxiliary materials according to conventional techniques.

The pharmaceutical composition of the present invention has the effects of soothing the liver, protecting the liver, protecting the liver, clearing heat and promoting dampness, reducing jaundice and softening the liver, and has good therapeutic effects on the treatment of viral hepatitis, such as hepatitis B, liver cirrhosis, liver ascites, etc. The effect is remarkable and there are no toxic side effects.

The following experimental examples are used to further illustrate the present invention, but are not limited thereto.

1. Experimental example

1. Clinical observation

Treatment group selects capsule of the present invention (prepared according to embodiment 1 method) to treat viral hepatitis 150 examples, wherein hepatitis B 50 examples, liver cirrhosis 50 examples, hepatic ascites 50 examples; Wherein male 70 examples, women 80 examples.

2. Drug selection and administration method

Treatment group chooses capsule of the present invention (prepared according to the method of embodiment 1), treats three courses for the treatment of (30 days one course of treatment), 3 times a day, each 2 capsules.

3. Diagnostic criteria

1) Hepatitis B

(1) Received blood and blood product treatment within six months, or had any medical injury such as unclean injection, acupuncture, puncture, surgery, etc., or had close contact with hepatitis B patients or hepatitis B virus carriers.

(2) Elevated serum ALT.

(3) Serum HBsAg positive with anti-HBcIgM positive (≥1:1000) or HBV-DNA positive.

2) liver cirrhosis

(1) Liver function test. For patients with liver disease, liver function test will help them understand the development stage of the disease and the degree of liver damage, which is very critical for the treatment of the disease.

(2) Virological index inspection, among the main inspection items of liver cirrhosis, this method is helpful for diagnosing what type of liver cirrhosis the patient is suffering from, and is also conducive to formulating a treatment plan .

(3) Pathological examination of liver biopsy. Before clinical treatment of liver cirrhosis (liver), it is ideal to do pathological examination of liver biopsy. It uses a 1-second puncture method, and then puts the liver tissue under a microscope for inspection. Its pathological data is of great help in understanding whether the patient's liver has fibrosis and the formation of connective tissue.

(4) Take blood to check 4 serological indicators of fibrosis, these 4 serum indicators are mainly hyaluronic acid, laminin, type III procollagen, and type IV collagen. Once 2-3 of them have a significant increase, then it can be considered whether early liver cirrhosis (liver) has occurred.

(5) B-ultrasound examination, when the early liver cirrhosis (liver) occurs, the patient's hepatomegaly can be found by this method. In addition, the liver echo will also show enhancement and thickening. This inspection method not only plays an important role in the early detection of diseases, but also is very beneficial to the diagnosis of advanced liver cirrhosis (liver) diseases.

3) Hepatic ascites

Ascites accompanied by generalized edema: generalized edema caused by any organic disease, if severe, may be accompanied by ascites. It often occurs in heart and kidney diseases and malnutrition, such as chronic heart failure, nephrotic syndrome, gastrointestinal protein loss syndrome, etc. The nature of ascites is transudate. Only ascites without systemic edema, or ascites appears in other parts of the edema.

4. Curative effect standard

1) Hepatitis B

The cure standard of hepatitis B includes clinical cure, basic cure and complete cure.

Clinical cure refers to the hepatitis B patients in the onset state, and it can be judged as clinical cure after the liver function is completely restored after treatment.

Basic cure and complete cure are for most people with hepatitis B, including both virus carriers and hepatitis B patients in the onset state. It means that the main replication indicators of hepatitis B virus, hepatitis B e antigen and hepatitis B virus deoxyribonucleic acid (HBVDNA) test are negative , normal liver function, and can maintain more than 1 year.

Complete cure means that all antigenic indicators of hepatitis B virus have turned negative, and no hepatitis B virus exists in liver tissue examination. It has been clinically proven that there is a natural negative conversion rate of 2% to 4% per year. After treatment, the negative conversion rate may be slightly higher, and only less than 8% of hepatitis B patients can reach the standard of complete cure. Another 30% of hepatitis B patients can reach the standard of clinical cure through treatment.

2) liver cirrhosis

Liver cirrhosis can be caused by one or more reasons. The patient's liver cells undergo diffuse degeneration and necrosis, and eventually deform and harden, leading to liver cirrhosis. The curative effect standard of liver cirrhosis can be divided into four grades, namely cured, markedly effective, effective, and ineffective.

Cure: Ascites and jaundice completely disappear in patients who are clinically cured, clinical symptoms disappear or basically disappear, liver and spleen obviously retract and become soft or stable, liver function returns to normal, physical strength obviously recovers, and there is no recurrence within half a year after stopping the drug .

Significantly effective: The ascites and jaundice subside in patients with markedly effective treatment, the main clinical symptoms disappear, the physical strength is obviously restored, the liver and spleen are stable, and the liver function is also significantly improved. If the cured patient relapses within half a year, it is also considered to be markedly effective.

Effective: After treatment, the patient's ascites and jaundice disappeared obviously, the clinical symptoms were alleviated, and the liver function was improved, which indicated that the treatment of liver cirrhosis had achieved results.

Ineffective: After half a month of standardized treatment, the patient's symptoms, signs, and liver function did not improve significantly, and even worsened or died, indicating that the treatment was ineffective.

3) Hepatic ascites

(1) Clinically cured: the condition has been effectively controlled, ascites, jaundice and other discomforts have completely disappeared, the liver and spleen have obviously shrunk and softened or remained stable, the liver function indicators have returned to normal, and the physical fitness has improved significantly, and After stopping the drug, ascites persists for more than half a year without recurrence.

(2) Significantly effective: the condition is effectively controlled, the main clinical symptoms (such as ascites, jaundice, etc.) are obviously subsided, the physical fitness and liver function are significantly improved, and there is no obvious change in the imaging examination of the liver and spleen.

(3) Effective: the condition has been effectively controlled, and the clinical discomfort symptoms, such as ascites, high jaundice, etc., have subsided, and the liver function has improved significantly.

(4) Ineffective: After half a month of treatment for hepatic ascites, clinical discomfort symptoms, signs, and liver function tests have not improved significantly, or the condition has further deteriorated or even died.

5. Treatment results

The curative effect result of table 1 medicine treatment hepatitis B of the present invention

group number of people treated cure markedly effective efficient invalid total effective rate therapy group 50 30 15 4 1 98%

The curative effect result of table 2 medicine treatment liver cirrhosis of the present invention

group number of people treated cure markedly effective efficient invalid total effective rate therapy group 50 25 15 8 2 96%

The curative effect result of table 3 medicine treatment liver ascites of the present invention

group number of people treated cure markedly effective efficient invalid total effective rate therapy group 50 28 15 5 2 96%

6 Conclusion

The medicine of the present invention treats 150 cases of viral hepatitis, three courses of treatment (12 days each), wherein the total effective rate of hepatitis B is 98%, and the total effective rate of liver cirrhosis and hepatic ascites is respectively 96%.

7. Discussion

The astragalus in the pharmaceutical composition of the present invention has the scientific name of Leguminosae in Latin, and has the functions of invigorating qi and consolidating the surface, diuresis and detumescence, supporting toxin and expulsion of pus, promoting granulation and the like. Codonopsis pilosula, Root of Pilose Asiabell, has the functions of invigorating the middle and replenishing qi, invigorating the spleen and lungs. Atractylodes macrocephala is the dried rhizome of Atractylodes macrocephala Koidz., a plant of the Compositae family. It has the effects of invigorating the spleen and replenishing qi, drying dampness and promoting diuresis, antiperspirant, and preventing miscarriage. The Latin scientific name of Poria cocos is Wolfiporia cocos. Poria cocos tastes sweet, light, and flat in nature. It has the functions of diuresis and dampness, benefiting the spleen and stomach, calming the mind and calming the nerves. Polygonatum sibiricum, the Latin scientific name Polygonatum sibiricum, has the effects of invigorating qi and nourishing yin, invigorating the spleen, moistening the lungs and benefiting the kidneys. The Latin scientific name of Ganoderma lucidum is Ganoderma lucidum. As a traditional Chinese medicinal material with thousands of years of medicinal history, Ganoderma lucidum has high medicinal value. After decades of modern pharmacological research by scientific research institutions, Ganoderma lucidum can enhance human immunity, regulate Blood sugar, blood pressure control, auxiliary tumor radiotherapy and chemotherapy, liver protection and liver protection, sleep promotion and other aspects have significant curative effects. Artemisia capillaris Thunb, the Latin name used at school, has the effect of clearing away heat and promoting dampness; reducing jaundice. Dandelion is a perennial herb of Compositae, which has diuretic, laxative, jaundice-reducing, choleretic and other effects. Qingyedan is the dry whole herb of Gentianaceae plant Swertiamilensis T.N.Ho et W.L.Shih, which has the functions of clearing away heat and detoxification; promoting dampness and reducing jaundice. Mainly damp-heat jaundice; hot stranguria and astringent pain; damp-heat diarrhea; red and white vaginal discharge; influenza; malaria fever; acute gastritis; acute pharyngitis; acute tonsillitis. The dried root of the cruciferous plant Isatis indigotica Fort. has the effects of clearing heat and detoxifying, cooling blood and reducing swelling, and relieving throat. The dry roots and rhizomes of Rheum palmatum L., Rheum tanguticum Maxim.ex Balf., or medicinal Rheum officinale Baill. have the functions of attacking stagnation, clearing dampness and heat, purging fire, cooling blood, dispelling Blood stasis, detoxification and other effects. Hedyotis diffusa is the whole herb of Hedyotis diffusa Willd. [Oldenlandia diffusa (Willd.) Roxb.], a Rubiaceae plant. Polygonum multiflorum is the dried root of Polygonum multiflorum Thunb., a Polygonum multiflorum Thunb. It has the effects of nourishing essence and blood, black beard and hair, strengthening muscles and bones, and nourishing liver and kidney. Ziheche is the dry placenta of healthy people, which can promote the development of mammary gland, uterus, vagina and testis, and also promote the thyroid gland. It also has good effects on tuberculosis, bronchial asthma, anemia, etc. Schisandra chinensis (Schisandrachinensis (Turcz.) Baill.) is the dried and mature fruit of Magnolia plant Schisandrachinensis (Turcz.) Baill. Treatment of asthma and cough due to lung deficiency, dry mouth and thirst, spontaneous sweating, night sweats, fatigue and emaciation, nocturnal nocturnal emission, chronic diarrhea and dysentery. Ligustrum lucidum is the dry and mature fruit of Ligustrum lucidum Ait., a plant of the Oleaceae family. It has the effects of nourishing the liver and kidney; clearing deficiency and heat; and improving eyesight. Polyporus umbellatus is the dried sclerotium of Polyporus umbellatus (Pers.) Fries, a fungus of the Polyporaceae family. It has the effect of diuresis and dampness, and is used for dysuria, edema, diarrhea, turbidity, and leukorrhea. The scientific name of white peony is Paeoniasterniana Fletcher in Journ., also known as white peony, which is a plant of the genus Paeoniae in the Ranunculaceae family. Salvia miltiorrhiza is also known as red ginseng, purple salvia miltiorrhiza, red root and so on. For dicotyledons Lamiaceae, dry roots and rhizomes. It has the effects of promoting blood circulation and regulating menstruation, dispelling blood stasis and relieving pain, cooling blood and eliminating carbuncle, clearing away heart-fire and relieving restlessness, nourishing blood and tranquilizing the nerves. Radix Paeoniae Rubra is the dried root of Paeonia lactiflora Pall. or Paeonia veitchii Lynch, a plant of the Ranunculaceae family. It has the effects of removing blood stasis, relieving pain, cooling blood, and reducing swelling. Panax notoginseng is the dry root of Panax notoginseng (Burk.) F.H.Chen. Hemostasis; Scattering of blood; Efficacy of relieving pain. Turmeric is the dry tuber root of Curcumawenyujin Y.H.Chen et C.Ling, Curcuma longa L., Curcumakwangsiensis S.G.Lee et C.F.Liang or Curcuma phaeocaulis Val. It has the effects of promoting qi and removing blood stasis, clearing the heart and relieving depression, promoting the gallbladder and reducing jaundice, promoting blood circulation and relieving pain, promoting qi and relieving depression, clearing the heart and cooling blood. The Latin scientific name of Bupleurum root of Chinese Thorowax has the effects of soothing the liver and gallbladder, dispersing qi and relieving depression, and dispersing fire. Fructus Amomi is the fruit or seed of tropical and subtropical Zingiberaceae plants, and is an aromatic medicinal material commonly used in traditional Chinese medicine. It has the effects of promoting qi and seasoning, harmonizing the stomach and refreshing the spleen. Pangolin dace carps pangolin Manis pentadactylaLinnaeus scales. It has the effect of promoting blood circulation and dispelling stagnation; dredging menstrual flow and lowering milk; eliminating carbuncle and ulcer. Cure mainly blood stasis amenorrhea; Lump in the abdomen; Rheumatism arthralgia; Milk retention; Carbuncle; Scrofula. The turtle shell is the carapace of the soft-shelled turtle Trionyx sinensis Wiegmann. It has the effects of nourishing kidney and suppressing yang, softening and resolving hard masses. [Indications] Guzheng labor fever, malaria, sideways hard, lumbago, amenorrhea embolism. The tortoise shell is the plastron and carapace of the turtle family chinemys reevesii. It has the functions of nourishing yin, subduing yang, tonifying kidney and strengthening bones. Licorice is the dry root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. of the leguminous plant Glycyrrhiza uralensis Fisch. It has the effects of clearing away heat and detoxification, eliminating phlegm and relieving cough, and abdominal distension. The pharmaceutical composition of the present invention has the effects of soothing the liver, protecting the liver, protecting the liver, clearing heat and promoting dampness, reducing jaundice and softening the liver, and has good therapeutic effects on the treatment of viral hepatitis, such as hepatitis B, liver cirrhosis, liver ascites, etc. Remarkable effect, no toxic side effects.

Experimental example 2: typical case

Case 1: The patient, male, 56 years old, Han nationality, Anhui nationality, suffered from hepatitis B for 10 years, complained of extreme fatigue, anorexia, abdominal distension and yellow stool, and was admitted to the hospital in 2012. Diagnostic criteria of western medicine: When seeing a doctor, the patient has dark complexion, weight loss, fatigue, dry mouth, upset, sometimes low-grade fever, large and firm abdomen, exposed blue veins, sometimes bloody teeth and nose, short red urine, red tongue, dark red with purple spots , pulse string number. Admission physical examination: 36.2C, pulse 80 beats/min, respiration 20 beats/min, blood pressure 110/20 mmHg, dull complexion, emaciated appearance, clear mind, normal orientation and calculation ability in physical examination cooperation, yellow skin all over the body , positive liver palms and spider nevus, no superficial lymph node enlargement, no conjunctival congestion and edema, mild yellow staining of the sclera, bilateral pupils equal in size and roundness, sensitive to light reflex, no abnormalities in the ears and nose, no resistance in the neck, and no thyroid gland Swelling, cardiopulmonary auscultation showed abnormal smell, abdominal distention, percussion pain in the liver area, positive shifting dullness, bowel sounds 5 times/min, no abnormalities in the spine, no abnormalities in the joints, and no abnormalities in nerve reflexes. Physical examination according to the medical history Diagnosed as hepatitis B cirrhosis ascites. Laboratory tests: alanine aminotransferase ALT300U/L; total bilirubin TBR96UM01/L; albumin ALB32g/L; hepatitis B antigen <HBSAS> positive; hepatitis B E antibody positive; hepatitis B core antibody positive; Normal value; HBV-DNA-positive abdominal B-ultrasound intrahepatic light spot picked up thickened and enhanced, splenomegaly 6.8mm, portal vein 13mm. TCM syndrome differentiation standard: swelling, accumulation; take capsules of the present invention (prepared according to the method of Example 1), three times a day, each 2 capsules. Note: Avoid smoking and alcohol, eat less raw, cold, greasy, fried food. After taking 3 courses of treatment (30 days for each course of treatment), the dark complexion disappeared, the weight increased, the size of the liver and spleen was improved, the abdominal distension and blue veins disappeared, the liver function returned to normal, the HBV-DNA turned negative, and the clinical cure was basically achieved.

Case 2: The patient, male, 32 years old, native of Henan, had yellow urine like tea juice without obvious inducement 2 months ago, followed by yellow staining of sclera, and did not improve after taking western medicine locally. He came here on June 3, 2012. Extremity weakness, epigastric discomfort, bitter and yellowish mouth, dry stool, yellow and greasy fur, stringy pulse. Western medicine diagnostic criteria: admission physical examination: 36.2C, pulse 80 beats/min, respiration 20 beats/min, blood pressure 120/20 mmHg, dull complexion, emaciated appearance, clear mind, normal orientation and calculation ability in physical examination cooperation, Yellow skin all over the body, positive liver palms and spider nevus, no superficial lymph node swelling, no conjunctival congestion and edema, mild yellow sclera, bilateral pupils equal in size and round, sensitive to light reflex, no abnormalities in the ears and nose, and no abnormalities in the neck. Resistance, no enlargement of the thyroid gland, abnormal smell and abnormalities on cardiopulmonary auscultation, abdominal distension, percussion pain in the liver area, bowel sounds 3 times/min, no abnormalities in the spine, no abnormalities in the joints, and no abnormalities in nerve reflexes, the diagnosis was made according to the medical history and physical examination For chronic hepatitis B cirrhosis {compensation period}. Laboratory examination: alanine aminotransferase ALT350U/L, total bilirubin TBR30UM01/L, albumin ALB34g/L, hepatitis B indicated antigen <HBSAS> positive, hepatitis B e antigen positive, hepatitis B core antibody positive, and the four items of liver fiber all exceeded Normal value, HBV-DNA positive, abdominal B-ultrasound intrahepatic light spots increased thickened and enhanced, splenomegaly 5.4mm, portal vein 12mm. TCM diagnostic criteria: anicteric chronic hepatitis B, liver and gallbladder damp-heat, woody and earthy. TCM syndrome differentiation and treatment: liver and gallbladder dampness and heat, woody wood suppressing soil, clearing away heat and detoxification, promoting dampness. Take the tablet of the present invention (prepared according to the method of Example 2), three times every day, 2 tablets each time. After the patient took it for a week, the yellowing of the sclera was significantly alleviated. After taking it for a month, the discomfort in the epigastric cavity, bitter taste turned yellow, dry stool, yellow and greasy fur, stringy and rapid pulse, and limb fatigue were obviously eliminated. Continue to take it for two months to consolidate, the main symptoms disappeared, the main signs of the patient returned to normal, the liver function returned to normal, and the two pairs of hepatitis B turned into 15 positive {small two positive} HBV-DNA negative.

Case 3: The patient, female, 41 years old, Han, was admitted to the hospital on September 12, 2010, mainly due to fatigue, abdominal distension, oily, yellow urine for three months, and whole body yellow for two months. The patient had no inducement three months ago, but experienced fatigue, oily urine, yellow urine, diarrhea and other discomforts. The test in the local hospital showed liver damage. More and more, the above-mentioned symptoms of the patient were aggravated, and at the same time, the skin of the whole body was yellowed, accompanied by skin itching, and the sclera was severely yellowed. Western medicine diagnostic criteria: Admission physical examination: 37.2C, pulse 82 beats/min, respiration 21 beats/min, blood pressure 130/80 mmHg, dull complexion, emaciated appearance, clear mind, normal orientation and calculation in physical examination, Severe skin yellowing all over the body, at the same time skin itching and scratches all over the body, positive liver palms and spider nevus, no superficial lymph node swelling, no conjunctival congestion and edema, mild yellowing of the sclera, bilateral pupils are large and round, Sensitive reflexes, no abnormalities in the ears and nose, no resistance in the neck, no enlarged thyroid gland, abnormal hearing and abnormalities on cardiopulmonary auscultation, percussion pain in the liver area, bowel sounds 3 times/min, no abnormalities in the spine, no abnormalities in the joints, and no nerve reflexes Abnormal, according to medical history and physical examination diagnosis of chronic hepatitis B. Laboratory tests: alanine aminotransferase ALT1680U/L, total bilirubin TBIL/98, protein ALB31g/L, liver fibrosis all exceeded normal values, HBV-DNA was positive, abdominal B-ultrasound intrahepatic light spots picked up, thickened and enhanced , splenomegaly 5.2 pulse 13mm, by taking granule of the present invention (prepared according to embodiment 3 method, every day three times, each 1 bag, 10 grams/bag.) after three months, symptom disappears, skin and sclera yellow stain and sign disappear, liver function returns to normal, serum bilirubin returns to normal, and clinical cure is achieved.

The following embodiments can all achieve the effects of the above experimental examples.

Embodiment 1 capsule

Astragalus 30kg Codonopsis Ginseng 30kg Atractylodes Rhizome 30kg

Poria cocos 30kg Polygonatum 30kg Ganoderma lucidum 30kg

Yin Chen 40kg Dandelion 40kg Green Leaf Gallbladder 15kg

Banlangen 20kg Rhubarb 10kg Hedyotis diffusa 20kg

Polygonum multiflorum 15kg Zihe cart 6kg Schisandra 20kg

Ligustrum lucidum 20kg, Porcini 10kg, Baishao 30kg

Danshen 40kg Radix Paeoniae Alba 30kg Sanqi 10kg

Turmeric 10kg Bupleurum 15kg Amomum kernel 15kg

Pangolin 6kg Turtle Armor 40kg Turtle Board 30kg

Licorice 10kg.

The above-mentioned medicines are prepared into clinically acceptable capsules by adding conventional auxiliary materials according to conventional techniques. Three times a day, 2 capsules each time.

Example 2 tablet

Astragalus 17kg Codonopsis ginseng 43kg Atractylodes macrocephala 17kg

Poria cocos 43kg Polygonatum 17kg Ganoderma lucidum 43kg

Yin Chen 25kg Dandelion 55kg Green Leaf Gallbladder 9kg

Banlangen 28kg Rhubarb 7kg Hedyotis diffusa 28kg

Polygonum multiflorum 9kg Ziheche 7kg Schisandra 12kg

Ligustrum lucidum 28kg, Porcini 7kg, Baishao 43kg

Danshen 25kg Radix Paeoniae Alba 43kg Sanqi 7kg

Turmeric 13kg Bupleurum 9kg Amomum 21kg

Pangolin 4kg Turtle Armor 55kg Turtle Board 17kg

Licorice 13kg.

The above-mentioned medicines are prepared into clinically acceptable capsules by adding conventional auxiliary materials according to conventional techniques. Three times a day, 2 tablets each time.

Embodiment 3 granules

Astragalus 43kg Codonopsis ginseng 17kg Atractylodes macrocephala 43kg

Poria cocos 17kg Polygonatum 43kg Ganoderma lucidum 17kg

Yin Chen 55kg Dandelion 25kg Green Leaf Gallbladder 21kg

Banlangen 12kg Rhubarb 13kg Hedyotis diffusa 12kg

Polygonum multiflorum 21kg Ziheche 5kg Schisandra 28kg

Ligustrum lucidum 12kg, Porcini 13kg, Baishao 17kg

Danshen 55kg Chishen 17kg Sanqi 13kg

Turmeric 7kg Bupleurum 21kg Amomum 9kg

Pangolin 7kg Turtle Armor 25kg Turtle Board 43kg

Licorice 7kg.

The above-mentioned drugs are prepared into clinically acceptable granules by adding conventional auxiliary materials according to conventional processes. Three times a day, 1 bag each time, 10g/bag.

Embodiment 4 pills

Astragalus 30kg Codonopsis Ginseng 30kg Atractylodes Rhizome 30kg

Poria cocos 30kg Polygonatum 30kg Ganoderma lucidum 30kg

Yin Chen 40kg Dandelion 40kg Green Leaf Gallbladder 15kg

Banlangen 20kg Rhubarb 10kg Hedyotis diffusa 20kg

Polygonum multiflorum 15kg Zihe cart 6kg Schisandra 20kg

Ligustrum lucidum 20kg, Porcini 10kg, Baishao 30kg

Danshen 40kg Radix Paeoniae Alba 30kg Sanqi 10kg

Turmeric 10kg Bupleurum 15kg Amomum kernel 15kg

Pangolin 6kg Turtle Armor 40kg Turtle Board 30kg

Licorice 10kg.

The above-mentioned medicines are prepared into clinically acceptable pills by adding conventional auxiliary materials according to conventional processes.

Embodiment 5 oral liquid

Astragalus 17kg Codonopsis ginseng 43kg Atractylodes macrocephala 17kg

Poria cocos 43kg Polygonatum 17kg Ganoderma lucidum 43kg

Yin Chen 25kg Dandelion 55kg Green Leaf Gallbladder 9kg

Banlangen 28kg Rhubarb 7kg Hedyotis diffusa 28kg

Polygonum multiflorum 9kg Ziheche 7kg Schisandra 12kg

Ligustrum lucidum 28kg, Porcini 7kg, Baishao 43kg

Danshen 25kg Radix Paeoniae Alba 43kg Sanqi 7kg

Turmeric 13kg Bupleurum 9kg Amomum 21kg

Pangolin 4kg Turtle Armor 55kg Turtle Board 17kg

Licorice 13kg.

The above-mentioned medicine is prepared into a clinically acceptable oral liquid by adding conventional auxiliary materials according to a conventional process.

Claims (6)

1. a pharmaceutical composition for the treatment of viral hepatitis, characterized in that the composition is made from the following raw materials: 2. The pharmaceutical composition according to claim 1, characterized in that the pharmaceutical composition is made into clinically acceptable tablets, granules, capsules, pills, oral liquids or decoctions by adding conventional adjuvants according to conventional processes. 3. The application of the pharmaceutical composition as claimed in claim 1 in the preparation of medicine for the treatment of viral hepatitis. 4. The application of the pharmaceutical composition as claimed in claim 1 in the preparation of medicines for the treatment of hepatitis B. 5. The application of the pharmaceutical composition as claimed in claim 1 in the preparation of medicine for the treatment of liver cirrhosis. 6. the application of pharmaceutical composition as claimed in claim 1 in the medicine of preparation treatment liver ascites.