CN103202928A - Traditional Chinese medicine composition with anti-aging function and application of same in anti-aging cosmetic - Google Patents
Traditional Chinese medicine composition with anti-aging function and application of same in anti-aging cosmetic Download PDFInfo
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- CN103202928A CN103202928A CN2012101971278A CN201210197127A CN103202928A CN 103202928 A CN103202928 A CN 103202928A CN 2012101971278 A CN2012101971278 A CN 2012101971278A CN 201210197127 A CN201210197127 A CN 201210197127A CN 103202928 A CN103202928 A CN 103202928A
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- 239000003814 drug Substances 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 26
- 239000002537 cosmetic Substances 0.000 title claims abstract description 21
- -1 powdery Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 239000006072 paste Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 abstract description 11
- 102000003425 Tyrosinase Human genes 0.000 abstract description 4
- 108060008724 Tyrosinase Proteins 0.000 abstract description 4
- 230000002087 whitening effect Effects 0.000 abstract 2
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- 235000007457 Jasminum sambac Nutrition 0.000 abstract 1
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- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
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- 235000006508 Nelumbo nucifera Nutrition 0.000 abstract 1
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- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 4
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- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
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- 235000021355 Stearic acid Nutrition 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
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- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention discloses a traditional Chinese medicine composition with an anti-aging function and application of the same in an anti-aging cosmetic. The traditional Chinese medicine composition is prepared through complex formulation of a wolfberry extract, an Arabian jasmine flower extract, a lotus plumule extract, a fleece-flower root extract, a Sichuan lovage rhizome extract, a weeping forsythia capsule extract and a pipewort flower extract. The traditional Chinese medicine provided by the invention can be used in an anti-aging and whitening formula and has the functions of inhibiting activity of tyrosinase, removing free radicals and whitening the skin.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and the application in cosmetics thereof, relate in particular to a kind of the have Chinese medicine composition of anti-senescence function and the application in cosmetics thereof.
Background technology
Along with Chinese society is stepped into aging gradually, the anti-aging beauty-care skin-protection product more and more is subject to people's attention.It is generally acknowledged that the action effect of anti aging effect active substance comprises the removing free radical, improve cell proliferation rate, delay degradation of extracellular matrix speed.Simultaneously, anti-aging cosmetics need be selected good skin-care agent, replenishes enough nutrients to skin, reaches deep layer nutrition.In addition, also to slow down scattering and disappearing of moisture in the skin, protection skin.At present, the effect evaluation of anti-aging cosmetics is mainly estimated two aspects from in-vitro evaluation and human body and is carried out.
At present, all there are big defective in the management of China's cosmetics and technology, and the phenomenon of adding is very serious in violation of rules and regulations, has caused many beauty treatment accidents for many years, even has disfeatured, and has caused very big injury to consumer, has caused the great attention of country and consumer.Exploitation has good safety, stability, and effect is obvious, and the natural defying age additive that cost performance is good has become one of main direction of studying of current medicine and cosmetic industry, has extraordinary development prospect.Natural materials is applied to cosmetics can reach skin treating and skin protection double effects, and has diverse in function, characteristic such as widely applicable, safe, thereby comes into one's own day by day.
Summary of the invention
The present invention wants the technical solution problem to provide a kind of natural Chinese medicine composition to the high and effective anti-senescence function of human safety that is derived from.
Another technical problem to be solved by this invention provides the application of above-mentioned Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is as follows:
A kind of Chinese medicine composition with anti-senescence function is characterized in that it comprises the component of following percentage by weight:
Above-mentioned Chinese medicine extract can obtain by conventional solvent extraction method, after for example above-mentioned Chinese medicine can being pulverized, sieve, with extract that solvent soaks or reflux after, filter, concentrate and obtain.For fear of dissolvent residual, the extraction solvent that uses among the present invention can adopt water, ethanol, ethanol water.In order to obtain the optimum extraction effect, the present invention has carried out the screening of extracting solvent, extracting extraction process conditions such as pressure, liquid material mass ratio, extraction time, has obtained the optimum extraction process condition, is shown in Table 1.
Table 1
The application of above-mentioned Chinese medicine composition in the preparation anti-aging cosmetics.
With respect to the total amount of cosmetics, the consumption of above-mentioned plant extract in the anti-aging cosmetics of the present invention in dry thing, is 0.05～20% (w/w), and preferable amount is 0.5～10% (w/w).
Chinese medicine composition of the present invention is used in anti-aging cosmetics, except above-mentioned essential composition, can suitably cooperate the composition that in cosmetics, uses usually as required, for example, matrix components such as other antidotal agent, wetting agent, surfactant, alcohols, water.
The dosage form of anti-aging cosmetics is not particularly limited, and can be solution, suspension, emulsion, paste, powdery, spray etc.
Beneficial effect: the Chinese medicine composition with anti-senescence function of the present invention has the effect that suppresses melanocyte, restraint of tyrosinase, free radical resisting.Can effectively suppress melanin and generate, desalination pigmentation, Glycerin etc.Compare with other antidotal agents, said composition can suppress melanic synthetic from different approach comprehensively, removes harmful free radical, has excellent anti-senescence function, simultaneously, said composition does not contain the chemosynthesis material, has no side effect, skin irritation is little, and stable in properties is safe and reliable.Except having anti-senescence function, because said composition contains the plurality of Chinese active component, have functions such as activating blood circulation to dissipate blood stasis, antiinflammatory be antibacterial, can promote skin metabolism, improve the nutrition of skin with healthy, have good skin effect.
Description of drawings
Fig. 1 is the comparison diagram of anti-aging cream and control sample performance of keeping humidity;
Fig. 2 is the comparison diagram of anti-aging cream and control sample skin elasticity;
Fig. 3 is the comparison diagram that anti-aging cream and control sample melanin content change.
The specific embodiment
The present invention will be described in more detail to enumerate embodiment below, but technical scope of the present invention is not limited by these embodiment.Below all proportional quantities all by weight percentage.
1, the preparation of sample
The Chinese medicine crude drug spends the night in oven drying, pulverizes the back and crosses 40 mesh sieves, adds 10 times of distilled water, heating and refluxing extraction 3 times, each 1 hour.Merge extractive liquid,, sucking filtration.Filtrate decompression concentrates, and places.Except precipitation, supernatant is collected 70% ethanol elution by D101 macroporous resin eluting, and reduced vacuum concentrates, and obtains Chinese medicine extract.It is 1% sample solution that extract is made into concentration, carries out following experiment.
2, the mensuration of restraint of tyrosinase vigor
According to the following table application of sample, do not add tryrosinase, 1% arbutin is compared as one group of sample.Solution is placed 37 ℃ of water-bath constant temperature 10min; Add tryrosinase, solution is placed 37 ℃ of water-bath constant temperature 10min after, under 475nm, measure its absorbance, and compare with 1% arbutin.
Table 2
By the relative inhibition (I be called for short suppression ratio, down together) of formula (1) calculation sample to tryrosinase.
In the formula: A
1, A
2, A
3, A
4Be respectively 1 group～4 groups solution absorbency.
3, the mensuration of ultra-oxygen anion free radical scavenging action
Get the Tris-HCl buffer 4.5mL of 0.05mol/LpH=8.2, preheating 20min in 25 ℃ of water-baths.The pyrogallol solution that adds 1mL sample and 0.4mL 25mmol/L again behind the mixing, reacts 5min in 25 ℃ of water-baths, add the HCl 1.0mL cessation reaction of 8mol/L.Make reference with the Tris-HCl buffer, survey absorbance at the 299nm place.Blank substitutes sample with the solvent of 1mL sample.Calculate clearance rate (D) according to formula (2).
Clearance rate formula (%)=[1-(A
2/ A
1)] * 100% (2)
A in the formula
1Absorbance for blank; A
2Absorbance for medicine.
4, the removing ability of hydroxy radical is measured
In the 25mL color comparison tube, add 2mmol/LFeSO successively
43mL, 1mmol/LH
2O
23mL shakes up, and then adds 6mmol/L salicylic acid 3mL, shakes up, and takes out behind 37 ℃ of heating in water bath 15min, surveys its absorbance; Add certain density liquid to be measured respectively, shake up, continue heating in water bath 15min, take out and survey its absorbance.Following formula is liquid to be measured to the clearance rate of carboxylic free radical (OH):
OH clearance rate (%)=[A
1-A
2-(A
1-A
3)]/A
1* 100% (3)
A in the formula
1For not adding the absorbance of reaction system before the medicine; A
2Absorbance for system behind the medicine removing OH; A
3Absorbance for system behind the blank removing OH.
5, experimental result
The anti-senescence function evaluation experimental is as follows.
Table 3 experimental result
Experiment shows that Chinese medicine composition of the present invention is the restraint of tyrosinase activity effectively, has the function of removing free radical simultaneously.
Chinese medicine composition (I) with anti-senescence function is composed as follows:
Chinese medicine composition (II) with anti-senescence function is composed as follows:
Table 4 provides the anti-aging cream prescription that contains Chinese medicine composition, and the consumption of each material is represented with mass fraction.
Table 4
Preparation: the dimethyl siloxane in the formula table, isopropyl palmitate, sad caprin, monoglyceride, stearic acid, methyl hydroxybenzoate, propylparaben are mixed, be heated to 80 ℃, fusing stirs, as oil phase; With 1 in the formula table, 2-propylene glycol, Chinese medicine extraction compositions, triethanolamine, deionized water mix, and are heated to 85 ℃, and stirring and dissolving is even, as water.Oil phase and water are added in the emulsifying pot, stir, the emulsifying homogenizing stirred when being cooled to 50 ℃ after 6 minutes, added essence, stirred, and was cooled to 38 ℃, was anti-aging cream.
Test according to " cosmetics health standard " (version in 2007).Press embodiment 3 preparation Fructus Lycii protective skin cream, choose Chinese medicine extraction composition I I, select the volunteer of 30 (10 male, 20 women) healthy, no cosmetic allergic contact dermatitis histories, carry out the detection of anti-aging cream moisture retention, skin elasticity and dermal melanin.
The moisture retention testing result is seen the shown in Figure 1 of accompanying drawing.
The skin elasticity testing result is seen the shown in Figure 2 of accompanying drawing.
The dermal melanin content detection the results are shown in the shown in Figure 3 of accompanying drawing.
Testing result shows that anti-aging cream has the effect of preserving moisture, whiten, strengthen skin elasticity, can delay skin aging, and to the skin nonirritant.
Claims (3)
1. Chinese medicine composition with anti-senescence function is characterized in that it is made up of the component of following percentage by weight:
2. the application of the described Chinese medicine composition of claim 1 in anti-aging cosmetics is characterized in that this anti-aging cosmetics contains the described Chinese medicine composition of claim 1, and its consumption is counted 0.05～20% (w/w) with dry thing.
3. the described anti-aging cosmetics of claim 2 is characterized in that dosage form is not particularly limited, and can be solution, suspension, emulsion, paste, powdery, spray etc.
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|---|---|---|---|
| CN201210197127.8A CN103202928B (en) | 2012-06-15 | 2012-06-15 | Traditional Chinese medicine composition with anti-aging function and application of same in anti-aging cosmetic |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210197127.8A CN103202928B (en) | 2012-06-15 | 2012-06-15 | Traditional Chinese medicine composition with anti-aging function and application of same in anti-aging cosmetic |
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| CN103202928A true CN103202928A (en) | 2013-07-17 |
| CN103202928B CN103202928B (en) | 2015-07-08 |
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|---|---|---|---|
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103564503A (en) * | 2013-10-29 | 2014-02-12 | 无限极（中国）有限公司 | Application of fructus forsythia extract in preparation of health food or cosmetic with UVA (Ultraviolet A) radiation resistance and anti-aging effect |
| CN103751071A (en) * | 2014-02-12 | 2014-04-30 | 云南省药物研究所 | Non-fragrance and non-trace type skin maintaining agent for men and preparation method thereof |
| CN105232384A (en) * | 2015-10-28 | 2016-01-13 | 青海尤尼克生物技术有限公司 | Anti-aging lycium barbarum skin-care product |
| CN117679317A (en) * | 2023-10-26 | 2024-03-12 | 广东食品药品职业学院 | Moisturizing, sun-proof and anti-wrinkle emulsion and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113778A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Preparation for treating senile diseases |
-
2012
- 2012-06-15 CN CN201210197127.8A patent/CN103202928B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113778A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Preparation for treating senile diseases |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103564503A (en) * | 2013-10-29 | 2014-02-12 | 无限极（中国）有限公司 | Application of fructus forsythia extract in preparation of health food or cosmetic with UVA (Ultraviolet A) radiation resistance and anti-aging effect |
| CN103564503B (en) * | 2013-10-29 | 2015-12-30 | 无限极（中国）有限公司 | Forsythia suspense extraction is preparing the application in the health food or cosmetics with uv-resistant A radiation and senile-resistant efficacy |
| CN103751071A (en) * | 2014-02-12 | 2014-04-30 | 云南省药物研究所 | Non-fragrance and non-trace type skin maintaining agent for men and preparation method thereof |
| CN103751071B (en) * | 2014-02-12 | 2016-08-24 | 云南省药物研究所 | A kind of zero fragrant seamless skin maintenance agent for men only and preparation method thereof |
| CN105232384A (en) * | 2015-10-28 | 2016-01-13 | 青海尤尼克生物技术有限公司 | Anti-aging lycium barbarum skin-care product |
| CN117679317A (en) * | 2023-10-26 | 2024-03-12 | 广东食品药品职业学院 | Moisturizing, sun-proof and anti-wrinkle emulsion and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN103202928B (en) | 2015-07-08 |
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